Search

Your search keyword '"JOOS, GUY"' showing total 756 results
Start Over Author "JOOS, GUY"
756 results on '"JOOS, GUY"'

151. Mouse models to unravel the role of inhaled pollutants on allergic sensitization and airway inflammation

Author

Nemery Benoit, Vanoirbeek Jeroen AJ, Cataldo Didier D, Lanckacker Ellen A, Provoost Sharen, Maes Tania, Tournoy Kurt G, and Joos Guy F

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Air pollutant exposure has been linked to a rise in wheezing illnesses. Clinical data highlight that exposure to mainstream tobacco smoke (MS) and environmental tobacco smoke (ETS) as well as exposure to diesel exhaust particles (DEP) could promote allergic sensitization or aggravate symptoms of asthma, suggesting a role for these inhaled pollutants in the pathogenesis of asthma. Mouse models are a valuable tool to study the potential effects of these pollutants in the pathogenesis of asthma, with the opportunity to investigate their impact during processes leading to sensitization, acute inflammation and chronic disease. Mice allow us to perform mechanistic studies and to evaluate the importance of specific cell types in asthma pathogenesis. In this review, the major clinical effects of tobacco smoke and diesel exhaust exposure regarding to asthma development and progression are described. Clinical data are compared with findings from murine models of asthma and inhalable pollutant exposure. Moreover, the potential mechanisms by which both pollutants could aggravate asthma are discussed.

Published
2010
Full Text
View/download PDF

153. Role of the tachykinin NK1 receptor in a murine model of cigarette smoke-induced pulmonary inflammation

Author

Brusselle Guy G, Demoor Tine, Bracke Ken R, De Swert Katelijne O, and Joos Guy F

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Background The tachykinins, substance P and neurokinin A, present in sensory nerves and inflammatory cells such as macrophages and dendritic cells, are considered as pro-inflammatory agents. Inflammation of the airways and lung parenchyma plays a major role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and increased tachykinin levels are recovered from the airways of COPD patients. The aim of our study was to clarify the involvement of the tachykinin NK1 receptor, the preferential receptor for substance P, in cigarette smoke (CS)-induced pulmonary inflammation and emphysema in a mouse model of COPD. Methods Tachykinin NK1 receptor knockout (NK1-R-/-) mice and their wild type controls (all in a mixed 129/sv-C57BL/6 background) were subjected to sub acute (4 weeks) or chronic (24 weeks) exposure to air or CS. 24 hours after the last exposure, pulmonary inflammation and development of emphysema were evaluated. Results Sub acute and chronic exposure to CS resulted in a substantial accumulation of inflammatory cells in the airways of both WT and NK1-R-/- mice. However, the CS-induced increase in macrophages and dendritic cells was significantly impaired in NK1-R-/- mice, compared to WT controls, and correlated with an attenuated release of MIP-3α/CCL20 and TGF-β1. Chronic exposure to CS resulted in development of pulmonary emphysema in WT mice. NK1-R-/- mice showed already enlarged airspaces upon air-exposure. Upon CS-exposure, the NK1-R-/- mice did not develop additional destruction of the lung parenchyma. Moreover, an impaired production of MMP-12 by alveolar macrophages upon CS-exposure was observed in these KO mice. In a pharmacological validation experiment using the NK1 receptor antagonist RP 67580, we confirmed the protective effect of absence of the NK1 receptor on CS-induced pulmonary inflammation. Conclusion These data suggest that the tachykinin NK1 receptor is involved in the accumulation of macrophages and dendritic cells in the airways upon CS-exposure and in the development of smoking-induced emphysema. As both inflammation of the airways and parenchymal destruction are important characteristics of COPD, these findings may have implications in the future treatment of this devastating disease.

Published
2009
Full Text
View/download PDF

154. Cigarette smoke enhances Th-2 driven airway inflammation and delays inhalational tolerance

Author

Joos Guy F, Maes Tania, Moerloose Katrien, Van Hove Chris L, and Tournoy Kurt G

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Active smoking increases asthma severity and is related to diminished treatment efficacy. Animal models in which inhalation of both allergen and mainstream cigarette smoke are combined can help us to understand the complex interaction between both agents. We have recently shown that, in allergic mice, the airway inflammation can be cleared by repeated allergen challenge, resulting in the establishment of a state of inhalational tolerance. Methods In this study, we assessed in vivo the impact of cigarette smoke on the efficacy and time course of this form of tolerance induction. We exposed sensitized mice to concurrent mainstream cigarette smoke and allergen (Ovalbumin- OVA) and measured the airway inflammation at different time points. Results We first confirmed that aerosolized OVA administered for a prolonged time period (4–8 weeks) resulted in the establishment of tolerance. Concurrent OVA and smoke exposure for 2 weeks showed that tobacco smoke enhanced the Th-2 driven airway inflammation in the acute phase. In addition, the induction of the tolerance by repeated inhalational OVA challenge was delayed significantly by the tobacco smoke, since 4 weeks of concurrent exposure resulted in a more persistent eosinophilic airway inflammation, paralleled by a more mature dendritic cell phenotype. However, smoke exposure could not prevent the establishment of tolerance after 8 weeks of antigen exposure as shown by both histopathology (disappearance of the Th-2 driven inflammation) and by in vivo functional experiments. In these tolerized mice, some of the inflammatory responses to the smoke were even attenuated. Conclusion Cigarette smoke enhances acute allergic inflammation and delays, but does not abrogate the development of tolerance due to prolonged challenge with inhaled antigen in experimental asthma.

Published
2008
Full Text
View/download PDF

157. Rhinology Future Debates 2017 by EUFOREA: Novel treatments and surgical solutions in rhinology

Author

UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, UCL - (SLuc) Centre de l'allergie, Fokkens, Wytske J., Pugin, Benoit, Bachert, Claus, Bousquet, Jean, Joos, Guy, Louis, Renaud, Pilette, Charles, Pfaar, Oliver, Price, David, Prokopakis, Emmanuel, Scadding, Glenis, Strzembosz, Agnieszka, Weilandt, Anders, Seys, Sven, Hellings, Peter W., UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, UCL - (SLuc) Centre de l'allergie, Fokkens, Wytske J., Pugin, Benoit, Bachert, Claus, Bousquet, Jean, Joos, Guy, Louis, Renaud, Pilette, Charles, Pfaar, Oliver, Price, David, Prokopakis, Emmanuel, Scadding, Glenis, Strzembosz, Agnieszka, Weilandt, Anders, Seys, Sven, and Hellings, Peter W.

Abstract

1 INTRODUCTION : The Rhinology Future Debates is a unique clinician‐orientated initiative organised by the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA). EUFOREA (www.euforea.eu) is an international non‐profit organisation aiming at reducing the prevalence and burden of chronic respiratory diseases. EUFOREA brings together specialists from the entire healthcare system to create opportunities for innovative thinking and development of new techniques, devices, protocols and concepts for a patient‐centred approach in prevention and optimal care.1 Advocacy for integrated care pathways and implementation of precision medicine in respiratory diseases are key priorities of the EUFOREA team.2, 3 The Rhinology Future Debates have been organised for the first time in 2016 and aim at filling the gap between industry‐investor meetings and clinicians working with patients affected by upper respiratory diseases. The debates deal with topics of innovation in diagnostic and therapeutic approaches, including novel devices, molecules and e‐health tools and other innovative solutions. The second Rhinology Future Debate took place in Brussels in December 2017 and brought together key experts in the field of respiratory diseases, industrial partners and patients for a discussion forum in the respiratory field. Debate topics in 2017 included (a) Real World Evidence data in AIT—What does it bring to us?, (b) Positioning Dymista in Allergic Rhinitis treatment (a separate report is available for this debate), (c) Nasal turbinate as therapeutic target in patients with turbinate‐induced nasal symptoms, and (d) Lessons from biologicals in asthma for ENT physicians. The debates were fully recorded and are available online (www.euforea.eu; www.rhinology-future.com) (Figure 1). This report summarises the key messages from each debate and further consolidates the discussion by providing additional evidences of the current state of the art in the field through l

Published
2018

158. Optimising experimental research in respiratory diseases: an ERS statement

Author

Bonniaud, Philippe, Fabre, Aurelie, Frossard, Nelly, Guignabert, Christophe, Inman, Mark, Kuebler, Wolfgang M., Maes, Tania, Shi, Wei, Stampfli, Martin, Uhlig, Stefan, White, Eric, Witzenrath, Martin, Bellaye, Pierre-Simon, Crestani, Bruno, Eickelberg, Oliver, Fehrenbach, Heinz, Guenther, Andreas, Jenkins, Gisli, Joos, Guy, Magnan, Antoine, Maitre, Bernard, Maus, Ulrich A., Reinhold, Petra, Vernooy, Juanita H. J., Richeldi, Luca, Kolb, Martin, Bonniaud, Philippe, Fabre, Aurelie, Frossard, Nelly, Guignabert, Christophe, Inman, Mark, Kuebler, Wolfgang M., Maes, Tania, Shi, Wei, Stampfli, Martin, Uhlig, Stefan, White, Eric, Witzenrath, Martin, Bellaye, Pierre-Simon, Crestani, Bruno, Eickelberg, Oliver, Fehrenbach, Heinz, Guenther, Andreas, Jenkins, Gisli, Joos, Guy, Magnan, Antoine, Maitre, Bernard, Maus, Ulrich A., Reinhold, Petra, Vernooy, Juanita H. J., Richeldi, Luca, and Kolb, Martin

Abstract

Experimental models are critical for the understanding of lung health and disease and are indispensable for drug development. However, the pathogenetic and clinical relevance of the models is often unclear. Further, the use of animals in biomedical research is controversial from an ethical perspective. The objective of this task force was to issue a statement with research recommendations about lung disease models by facilitating in-depth discussions between respiratory scientists, and to provide an overview of the literature on the available models. Focus was put on their specific benefits and limitations. This will result in more efficient use of resources and greater reduction in the numbers of animals employed, thereby enhancing the ethical standards and translational capacity of experimental research. The task force statement addresses general issues of experimental research (ethics, species, sex, age, ex vivo and in vitro models, gene editing). The statement also includes research recommendations on modelling asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, lung infections, acute lung injury and pulmonary hypertension. The task force stressed the importance of using multiple models to strengthen validity of results, the need to increase the availability of human tissues and the importance of standard operating procedures and data quality.

Published
2018

159. Cigarette smoke exposure facilitates allergic sensitization in mice

Author

Brusselle Guy G, Maes Tania, Robays Lander J, Moerloose Katrien B, Tournoy Kurt G, and Joos Guy F

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Active and passive smoking are considered as risk factors for asthma development. The mechanisms involved are currently unexplained. Objective The aim of this study was to determine if cigarette smoke exposure could facilitate primary allergic sensitization. Methods BALB/c mice were exposed to aerosolized ovalbumin (OVA) combined with air or tobacco smoke (4 exposures/day) daily for three weeks. Serology, lung cytopathology, cytokine profiles in bronchoalveolar lavage fluid (BALF) and on mediastinal lymph node cultures as well as lung function tests were performed after the last exposure. The natural history and the immune memory of allergic sensitization were studied with in vivo recall experiments. Results Exposure to OVA induced a small increase in OVA-specific serum IgE as compared with exposure to PBS (P < 0.05), while no inflammatory reaction was observed in the airways. Exposure to cigarette smoke did not induce IgE, but was characterized by a small but significant neutrophilic inflammatory reaction. Combining OVA with cigarette smoke not only induced a significant increase in OVA-specific IgE but also a distinct eosinophil and goblet cell enriched airway inflammation albeit that airway hyperresponsiveness was not evidenced. FACS analysis showed in these mice increases in dendritic cells (DC) and CD4+ T-lymphocytes along with a marked increase in IL-5 measured in the supernatant of lymph node cell cultures. Immune memory experiments evidenced the transient nature of these phenomena. Conclusion In this study we show that mainstream cigarette smoke temporary disrupts the normal lung homeostatic tolerance to innocuous inhaled allergens, thereby inducing primary allergic sensitization. This is characterized not only by the development of persistent IgE, but also by the emergence of an eosinophil rich pulmonary inflammatory reaction.

Published
2006
Full Text
View/download PDF

160. Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema

Author

Joos Guy F, Bracke Ken R, Demoor Tine, Demedts Ingel K, and Brusselle Guy G

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Chronic obstructive pulmonary disease (COPD) is characterised by chronic inflammation of the airways and progressive destruction of lung parenchyma, a process that in most cases is initiated by cigarette smoking. Several mechanisms are involved in the development of the disease: influx of inflammatory cells into the lung (leading to chronic inflammation of the airways), imbalance between proteolytic and anti-proteolytic activity (resulting in the destruction of healthy lung tissue) and oxidative stress. Recently, an increasing number of data suggest a fourth important mechanism involved in the development of COPD: apoptosis of structural cells in the lung might possibly be an important upstream event in the pathogenesis of COPD. There is an increase in apoptotic alveolar epithelial and endothelial cells in the lungs of COPD patients. Since this is not counterbalanced by an increase in proliferation of these structural cells, the net result is destruction of lung tissue and the development of emphysema. Data from animal models suggest a role for Vascular Endothelial Growth Factor (VEGF) in the induction of apoptosis of structural cells in the lung. Other mediators of apoptosis, such as caspase-3 and ceramide, could be interesting targets to prevent apoptosis and the development of emphysema. In this review, recent data on the role of apoptosis in COPD from both animal models as well as from studies on human subjects will be discussed. The aim is to provide an up to date summary on the increasing knowledge on the role of apoptosis in COPD and pulmonary emphysema.

Published
2006
Full Text
View/download PDF

163. Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required?

Author

Tournoy Kurt G, Demedts Ingel K, Bracke Ken R, Maes Tania, D'hulst An I, Joos Guy F, and Brusselle Guy G

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Chronic obstructive pulmonary disease is associated with a chronic inflammatory response of the host to chronic exposure to inhaled toxic gases and particles. Although inflammatory cells of both the innate and adaptive immune system infiltrate the lungs in pulmonary emphysema and form lymphoid follicles around the small airways, the exact role of the acquired immune system in the pathogenesis of emphysema is not known. Methods In this study, wild type Balb/c mice and immunodeficient scid mice – which lack functional B- and T-cells – were exposed to mainstream cigarette smoke (CS) for 5 weeks or 6 months. Results Subacute CS-exposure for 5 weeks significantly increased innate inflammatory cells (neutrophils, macrophages and dendritic cells) in the bronchoalveolar lavage (BAL) fluid of wild type mice and scid mice, which correlated with the CS-induced upregulation of the chemokines Monocyte Chemotactic Protein-1, Macrophage Inflammatory Protein-3α and KC (= mouse Interleukin-8). Chronic CS-exposure for 6 months significantly increased the number of neutrophils, macrophages, dendritic cells, CD4+ and CD8+ T-lymphocytes in BAL fluid and lungs of wild type mice compared to air-exposed littermates, and augmented the size and number of peribronchial lymphoid follicles. In contrast, neither B-lymphocytes, nor T-lymphocytes, nor lymphoid follicles could be discerned in the lungs of air- or CS-exposed scid mice. Importantly, chronic CS-exposure induced pulmonary emphysema in both wild type animals and scid mice, as evidenced by a significant increase in the mean linear intercept and the destructive index of CS-exposed versus air-exposed animals. The CS-induced emphysema was associated with increased mRNA expression of matrix metalloproteinase-12 in the lungs and increased protein levels of Tumor Necrosis Factor-α in the BAL fluid of CS-exposed Balb/c and scid mice compared to air-exposed littermates. Conclusion This study suggests that the adaptive immune system is not required per se to develop pulmonary emphysema in response to chronic CS-exposure, since emphysema can be induced in scid mice, which lack lymphoid follicles as well as functional B- and T-cells.

Published
2005
Full Text
View/download PDF

166. Additional file 3: of Influence of chronic azithromycin treatment on the composition of the oropharyngeal microbial community in patients with severe asthma

Author

Santiago, Guido Lopes Dos Santos, Brusselle, Guy, Dauwe, Kenny, Deschaght, Pieter, Verhofstede, Chris, Vaneechoutte, Dries, Deschepper, Ellen, Jordens, Paul, Joos, Guy, and Vaneechoutte, Mario

Abstract

Beta diversity analysis of the oropharyngeal microbiomes of the azithromycin-treated patients: visit 2 versus visit 3. Legend: The Principal Coordinates Analysis plot using the phylogenetic-based unweighted UniFrac algorithm for the comparison of the oropharyngeal microbiomes of the non- azithromycin (AZ)-treated samples with the oropharyngeal microbiomes of the AZ-treated samples. Blue dots: non-AZ-treated samples (n = 8): the Visit 2 samples (before treatment) of the 8 AZ-treated subjects. Green dots: AZ-treated samples (n = 8): Visit 3 samples (one month after the start of treatment) of the 8 AZ-treated patients. Each dot is labeled with the patient number and visit code. (PPTX 66 kb)

Published
2017
Full Text
View/download PDF

168. Efficacy of tiotropium–olodaterol fixed-dose combination in COPD

Author

Derom,Eric, Brusselle,Guy, and Joos,Guy

Subjects
International Journal of Chronic Obstructive Pulmonary Disease, humanities, respiratory tract diseases
Abstract

Eric Derom, Guy G Brusselle, Guy F Joos Department of Respiratory Medicine, Ghent University Hospital, Ghent, BelgiumAbstract: Tiotropium–olodaterol, formulated in the Respimat soft-mist inhaler, is an inhaled fixed-dose combination (FDC) of a long-acting muscarinic antagonist (LAMA) and a long-acting β2-agonist (LABA), commercialized under the name of Spiolto or Stiolto. The efficacy of tiotropium–olodaterol 5–5 µg once daily in adult patients with COPD was documented in eleven large, multicenter trials of up to 52 weeks duration. Tiotropium–olodaterol 5–5 µg not only improved spirometric values to a significantly greater extent than placebo but also resulted in statistically significant beneficial effects on dyspnea, markers of hyperinflation, use of rescue medication, health-related quality of life, and exercise endurance. Improvements exceeded the minimal clinically important difference (MCID) for forced expiratory volume in 1 second (FEV1), dyspnea, and quality of life. Differences between tiotropium–olodaterol 5–5 µg and the respective monocomponents were statistically significant for FEV1, dyspnea, markers of hyperinflation, use of rescue medication, and health-related quality of life, but did not reach the MCID. However, dual bronchodilatation significantly increased the number of patients who exceeded the MCID for dyspnea and quality of life. Moreover, tiotropium–olodaterol 5–5 µg was significantly more effective than salmeterol–fluticasone (FDC) twice daily at improving pulmonary function. Differences between tiotropium–olodaterol and other LAMA/LABA FDCs were not observed for FEV1 or other efficacy markers. Therefore, tiotropium–olodaterol is a valuable option in the treatment of COPD patients who remain symptomatic under monotherapy. Keywords: COPD, bronchodilatation, dyspnea, exacerbation, exercise tolerance, LABA, LAMA, spirometry

Published
2016

174. The European Respiratory Society: ensuring excellence through education best practice

Author

Farr, Amy, primary, Gaga, Mina, additional, Welte, Tobias, additional, Troosters, Thierry, additional, Joos, Guy, additional, Robalo Cordeiro, Carlos, additional, Burghuber, O. Chris, additional, Brusselle, Guy, additional, Gratziou, Christina-Georgia, additional, Bush, Andrew, additional, Saraiva, Isabel, additional, Pannetier, Carine, additional, and Stolz, Daiana, additional

Published
2018
Full Text
View/download PDF

175. Rhinology Future Debates 2017 by EUFOREA: Novel treatments and surgical solutions in rhinology

Author

Fokkens, Wytske J., primary, Pugin, Benoit, additional, Bachert, Claus, additional, Bousquet, Jean, additional, Joos, Guy, additional, Louis, Renaud, additional, Pilette, Charles, additional, Pfaar, Oliver, additional, Price, David, additional, Prokopakis, Emmanuel, additional, Scadding, Glenis, additional, Strzembosz, Agnieszka, additional, Weilandt, Anders, additional, Seys, Sven, additional, and Hellings, Peter W., additional

Published
2018
Full Text
View/download PDF

176. Optimising experimental research in respiratory diseases: an ERS statement

Author

Bonniaud, Philippe, primary, Fabre, Aurélie, additional, Frossard, Nelly, additional, Guignabert, Christophe, additional, Inman, Mark, additional, Kuebler, Wolfgang M., additional, Maes, Tania, additional, Shi, Wei, additional, Stampfli, Martin, additional, Uhlig, Stefan, additional, White, Eric, additional, Witzenrath, Martin, additional, Bellaye, Pierre-Simon, additional, Crestani, Bruno, additional, Eickelberg, Oliver, additional, Fehrenbach, Heinz, additional, Guenther, Andreas, additional, Jenkins, Gisli, additional, Joos, Guy, additional, Magnan, Antoine, additional, Maitre, Bernard, additional, Maus, Ulrich A., additional, Reinhold, Petra, additional, Vernooy, Juanita H.J., additional, Richeldi, Luca, additional, and Kolb, Martin, additional

Published
2018
Full Text
View/download PDF

177. European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases: report of the European Union Parliament Summit (29 March 2017)

Author

Hellings, Peter W., primary, Borrelli, David, additional, Pietikainen, Sirpa, additional, Agache, Ioana, additional, Akdis, Cezmi, additional, Bachert, Claus, additional, Bewick, Michael, additional, Botjes, Erna, additional, Constantinidis, Jannis, additional, Fokkens, Wytske, additional, Haahtela, Tari, additional, Hopkins, Claire, additional, Illario, Maddalena, additional, Joos, Guy, additional, Lund, Valerie, additional, Muraro, Antonella, additional, Pugin, Benoit, additional, Seys, Sven, additional, Somekh, David, additional, Stjärne, Pär, additional, Valiulis, Arunas, additional, Valovirta, Erkka, additional, and Bousquet, Jean, additional

Published
2017
Full Text
View/download PDF

180. Inhaled treatment of COPD: A Delphi consensus statement

Author

Ninane, Vincent, Lehouck, An, Corhay, Jean Louis, Germonpré, Paul, Janssens, Wim, Joos, Guy, Liistro, Giuseppe, Vincken, Walter, Gurdain, Sandra, Vanvlasselaer, Evelyne, Ninane, Vincent, Lehouck, An, Corhay, Jean Louis, Germonpré, Paul, Janssens, Wim, Joos, Guy, Liistro, Giuseppe, Vincken, Walter, Gurdain, Sandra, and Vanvlasselaer, Evelyne

Abstract

Background: Global Initiative for Chronic Obstructive Lung Disease (GOLD) global strategy (2015) provides guidance for the treatment of chronic obstructive pulmonary disease (COPD) with different first-choice options per GOLD category without specification. Objectives: To evaluate the level of medical experts’ consensus on their preferred first-choice treatment within different COPD categories. Methods: A two-round Delphi Panel consisting of 15 questions was completed by Belgian pulmonologists (n=31) and European (n=10) COPD experts. Results: Good consensus was reached by both expert groups for long-acting bronchodilators instead of short-acting bronchodilators as first-choice treatment in GOLD A. Single bronchodilation with long-acting muscarinic antagonist (LAMA) was preferred over long-acting β2-agonist (LABA) and LABA/LAMA as first-choice treatment in GOLD B and GOLD C. For GOLD D patients based on the forced expiratory volume in 1 second (FEV1)<50%, a very good consensus was reached for LAMA/LABA as first-choice treatment. For GOLD D patients based on frequent or severe exacerbations, there was a good consensus for LABA/LAMA/inhaled corticosteroids (ICS) as first choice in the Belgian group. According to the European experts, both LABA/LAMA and LABA/LAMA/ICS could be the first choice for these patients. Conclusion: Belgian and European experts recommend long-acting bronchodilators as first-choice treatment. Treatment containing ICS was found only appropriate in patients with FEV1<50% and ≥2 moderate exacerbations or 1 severe exacerbation/year., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2017

181. Inhaled treatment of COPD: a Delphi consensus statement

Author

Ninane,Vincent, Corhay,Jean-Louis, Germonpré,Paul, Janssens,Wim, Joos,Guy F, Liistro,Giuseppe, Vincken,Walter, Gurdain,Sandra, Vanvlasselaer,Evelyne, Lehouck,An, Ninane,Vincent, Corhay,Jean-Louis, Germonpré,Paul, Janssens,Wim, Joos,Guy F, Liistro,Giuseppe, Vincken,Walter, Gurdain,Sandra, Vanvlasselaer,Evelyne, and Lehouck,An

Abstract

Vincent Ninane,1 Jean-Louis Corhay,2 Paul Germonpré,3 Wim Janssens,4 Guy F Joos,5 Giuseppe Liistro,6 Walter Vincken,7 Sandra Gurdain,8 Evelyne Vanvlasselaer,8 An Lehouck8 1Department of Respiratory Medicine, Saint-Pierre Hospital, Université Libre de Bruxelles, Brussels, 2Department of Respiratory Medicine, CHU, Liege, 3Department of Respiratory Medicine, AZ Maria Middelares, Ghent, 4Department of Respiratory Medicine, Katholieke Universiteit, Leuven, 5Department of Respiratory Medicine, Ghent University Hospital, Ghent, 6Department of Respiratory Medicine, University Hospitals Saint-Luc, Brussels, 7Department of Respiratory Medicine, University Hospital Brussels, Brussels, 8Medical Department, Novartis Pharma, Vilvoorde, Belgium Background: Global Initiative for Chronic Obstructive Lung Disease (GOLD) global strategy (2015) provides guidance for the treatment of chronic obstructive pulmonary disease (COPD) with different first-choice options per GOLD category without specification. Objectives: To evaluate the level of medical experts’ consensus on their preferred first-choice treatment within different COPD categories. Methods: A two-round Delphi Panel consisting of 15 questions was completed by Belgian pulmonologists (n=31) and European (n=10) COPD experts. Results: Good consensus was reached by both expert groups for long-acting bronchodilators instead of short-acting bronchodilators as first-choice treatment in GOLD A. Single bronchodilation with long-acting muscarinic antagonist (LAMA) was preferred over long-acting ß2-agonist (LABA) and LABA/LAMA as first-choice treatment in GOLD B and GOLD C. For GOLD D patients based on the forced expiratory volume in 1 second (FEV1)<50%, a very good consensus was reached for LAMA/LABA as first-choice treatment. For GOLD D patients based on frequent or severe exacerbations, there was a good consensus for LABA/LAMA/inhaled corticosteroids (ICS) as first choice in the Belgian gr

Published
2017

182. Belgian Severe Asthma Registry: Which Biotherapy to Choose According to Inflammatory Characteristics?

Author

Schleich, Florence N, Brusselle, Guy, Louis, Renaud, Vandenplas, Olivier, Michils, Alain, Pilette, Charles, Peché, Rudi, Joos, Guy, Schleich, Florence N, Brusselle, Guy, Louis, Renaud, Vandenplas, Olivier, Michils, Alain, Pilette, Charles, Peché, Rudi, and Joos, Guy

Abstract

info:eu-repo/semantics/published, Programs and Abstracts of Papers to be Presented During Scientific Sessions: 2017 AAAAI Annual Meeting

Published
2017

183. Belgian Severe Asthma Registry: Which Biotherapy to Choose According to Inflammatory Characteristics?

Author

Annual meeting of the American Academy of Asthma, Allergy and Immunology (March 3-7, 2017: Atlanta), Schleich, Florence N, Brusselle, Guy, Louis, Renaud, Vandenplas, Olivier, Michils, Alain, Pilette, Charles, Peché, Rudi, Joos, Guy, Annual meeting of the American Academy of Asthma, Allergy and Immunology (March 3-7, 2017: Atlanta), Schleich, Florence N, Brusselle, Guy, Louis, Renaud, Vandenplas, Olivier, Michils, Alain, Pilette, Charles, Peché, Rudi, and Joos, Guy

Abstract

info:eu-repo/semantics/nonPublished

Published
2017

189. Taken to task: what is and is not an appropriate response to an ERS guidelines task force?

Author

Joos, Guy, primary, Bush, Andrew, additional, Burghuber, Otto Chris, additional, Robalo Cordeiro, Carlos, additional, Gaga, Mina, additional, Gibson, G. John, additional, Gratziou, Christina, additional, Rigau, David, additional, Rohde, Gernot, additional, Smyth, Dan, additional, Stolz, Daiana, additional, Tonia, Thomy, additional, Vestbo, Jørgen, additional, Welte, Tobias, additional, Brusselle, Guy, additional, and Miravitlles, Marc, additional

Published
2017
Full Text
View/download PDF

190. Influence of chronic azithromycin treatment on the composition of the oropharyngeal microbial community in patients with severe asthma

Author

Lopes dos Santos Santiago, Guido, primary, Brusselle, Guy, additional, Dauwe, Kenny, additional, Deschaght, Pieter, additional, Verhofstede, Chris, additional, Vaneechoutte, Dries, additional, Deschepper, Ellen, additional, Jordens, Paul, additional, Joos, Guy, additional, and Vaneechoutte, Mario, additional

Published
2017
Full Text
View/download PDF

191. Inhaled treatment of COPD: a Delphi consensus statement

Author

Ninane, Vincent, primary, Corhay, Jean-Louis, additional, Germonpré, Paul, additional, Janssens, Wim, additional, Joos, Guy F, additional, Liistro, Giuseppe, additional, Vincken, Walter, additional, Gurdain, Sandra, additional, Vanvlasselaer, Evelyne, additional, and Lehouck, An, additional

Published
2017
Full Text
View/download PDF

195. Health literacy among asthma patients and treatment expectations: results of a Belgian survey

Author

Dupont, Lieven, Pilette, Charles, Schleich, Florence, and Joos, Guy

Abstract

ABSTRACTObjectives: Non-adherence to asthma medication can lead to lower disease control and asthma exacerbations that may be fatal. This survey assessed the attitude and expectations of Belgian asthma patients towards their treatment.Methods: This cross-sectional survey was conducted between June 2015 and February 2016 in 70 Belgian pharmacies. Participants completing the survey had to be ≥15 years, diagnosed with asthma, and on inhaled corticosteroid-based treatment. The analysis included 80 completed questionnaires.Results: Participants comprehended well that controller drugs are intended to prevent the occurrence of asthma symptoms and complications, and their long-term daily use should be maintained. Twenty seven percent of participants indicated fear of side effects concerning long-term daily use of a controller inhaler. Participants had a good understanding that quick-relief drugs are intended to (quickly) relieve asthma symptoms and do not need to be used on a systematic, daily basis. Out of 73 participants on long-term controller drugs, 33 (45%) were ‘non-adherent’ (used less frequently than prescribed). Suboptimal adherence to maintenance treatment appeared to increase nightly awakenings and the risk of restrictions in activities due to asthma. Out of 54 participants with available quick-relief drug adherence data, 18 (33%) were non-adherent (used their quick-relief drug more frequently than prescribed).Discussion: This survey confirms suboptimal adherence to maintenance controller therapy and overuse of short-acting reliever medications among Belgian patients, which affects asthma control and quality of life. A substantial proportion of patients expressed fear about their chronic therapy, indicating the need for patient education about their disease and its management.

Published
2020
Full Text
View/download PDF

196. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis

Author

Bousquet, Jean, Schünemann, Holger J., Hellings, Peter W., Arnavielhe, Sylvie, Bachert, Claus, Bedbrook, Anna, Bergmann, Karl Christian, Bosnic Anticevitch, Sinthia, Brozek, Jan L., Calderón, Moisés, Canonica, G. Walter, Casale, Thomas B., Chavannes, Niels H., Cox, Linda, Chrystyn, Henry, Cruz, Álvaro A., Dahl, Ronald, De Carlo, Giuseppe, Demoly, Pascal, Devillier, Phillipe, Dray, Gérard, Fletcher, Monica, Fokkens, Wytske J., Fonseca, Joao A., González Díaz, Sandra Nora, Grouse, Lawrence, Keil, Thomas, Kuna, Piotr, Larenas Linnemann, Désirée, Lodrup Carlsen, Karin C., Meltzer, E. O., Mullol, Jaoquim, Muraro, Antonella, Naclerio, Robert N., Palkonen, Susanna, Papadopoulos, Nikolaos G., Passalacqua, Giovanni, Price, David, Ryan, Dermot, Samolinski, Boleslaw, Scadding, Glenis K., Sheikh, Aziz, Spertini, François, Valiulis, Arunas, Valovirta, Erkka, Walker, Samantha, Wickman, Magnus, Yorgancioglu, Arzu, Haahtela, Tari, Zuberbier, Torsten, Aberer, Werner, Adachi, Mitsuru, Agache, Ioana, Akdis, Cezmi, Akdis, Mubeccel, Annesi Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Arshad, S. Hasan, Baiardini, Ilaria, Baigenzhin, Abay K., Barbara, Cristina, Bateman, Eric D., Beghé, Bianca, Bel, Elisabeth H., Ben Kheder, Ali, Bennoor, Kazi S., Benson, Michael, Bernstein, David, Michael, Bewick, Thomas, Bieber, Bindslev Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe A., Bousquet, Philippe J., Braido, Fulvio, Briggs, Andrew H., Brightling, Christopher E., Buhl, Roland, Burney, Peter G., Bush, Andrew, Caballero Fonseca, Fernando, Caimmi, Davide P., Camargos, Paulo, Camuzat, Thierry, Carlsen, Kai Hakon, Carr, Warner, Sarabia, Alfonso Cepeda, Chatzi, Leda, Chen, Yuzhi Z., Chiron, Raphaël, Chkhartishvili, Ekaterine, Chuchalin, Alexander G., Ciprandi, Georgio, Cirule, Ieva, Correia de Sousa, Jaime, Costa, David, Crooks, George, Custovic, Adnan, Dahlen, Sven Erik, Darsow, Ulf, De Blay, Frédéric, De Manuel Keenoy, Esteban, Dedeu, Tony, Deleanu, Diana, Denburg, Judah, Didier, Alain, Dinh Xuan, Anh Tuan, Dokic, Dejan, Douagui, Habib B., Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark S., El Gamal, Yehia, Emuzyte, Regina, Fink Wagner, Antje H., Fiocchi, Alessandro, Forastiere, Francesco, Gamkrelidze, Amiran, Gemicioğlu, Bilun, Gereda, José E., Gerth van Wijk, Roy, Gotua, Maia, Grisle, Ineta, Guzmán, M. Antonieta, Heinrich, Joachim, Hellquist Dahl, Birthe, Horak, Friedrich, Howarth, Peter H., Humbert, Marc, Hyland, Michael, Ivancevich, Juan Carlos, Jares, Edgardo José, Johnston, Sebastian L., Jonquet, Olivier, Joos, Guy, Jung, Ki Suck, Just, Jocelyne, Jutel, Marek, Kaidashev, Igor P., Khaitov, Musa R., Kalayci, Omer, Kalyoncu, Fuat, Keith, Paul K., Khaltaev, Nikolai, Kleine Tebbe, Jorg, Klimek, Ludger, N'Goran, Bernard Koffi, Kolek, Vítězslav, Koppelman, Gerard H., Kowalski, Marek, Kull, Inger, Kvedariene, Violeta, Lambrecht, Bart, Lau, Susanne, Laune, Daniel, Le Thi Tuyet, Lan, Li, Jingmei, Lieberman, Phillipe, Lipworth, Brian J., Renaud, Louis, Magard, Yves, Magnan, Antoine, Mahboub, Bassam, Majer, Ivan, Makela, Mika, Manning, Peter J., Masjedi, Mohamad R., Maurer, Marcus, Mavale Manuel, Sandra, Melén, Erik, Melo Gomes, Elisabete, Mercier, Jacques, Merk, Hans, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, Yousser, Molimard, Mathieu, Momas, Isabelle, Montilla Santana, Anna, Morais Almeida, Mario, Mösges, Ralph, Nadif, Rachel, Namazova Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Niggemann, Bodo, Nyembue, T. Dieudonné, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kim, Ouedraogo, Solange, Paggiaro, Pier Luigi, Pali Schöll, Isabella, Palmer, Stephen, Panzner, Petr, Papi, Alberto, Park, Hae-Sim, Pavord, Ian, Pawankar, Ruby, Pfaar, Oliver, Picard, Robert, Pigearias, Bernard, Pin, Isabelle, Plavec, Davor, Pohl, Wolfgang, Popov, Todor A., Postma, Dirkje S., Potter, Paul, Poulsen, Lars K., Rabe, Klaus F., Raciborski, Filip, Pontal, Françoise Radier, Reitamo, Sakari, Repka Ramírez, Maria Susana, Robalo Cordeiro, Carlos, Roberts, Graham, Rodenas, Francisco, Rolland, Christine, Rodriguez, Miguel Roman, Romano, Antonino, Rosado Pinto, José, Rosario, Nelson A., Rosenwasser, Larry, Rottem, Menachem, Sánchez Borges, Mario, Sastre Dominguez, Joaquim, Schmid Grendelmeier, Peter, Serrano, Eli, Simons, F. Estelle R., Sisul Alvariza, Juan Carlos, Skrindo, Ingebjorg, Smit, Henriette A., Solé, Dirceu, Sooronbaev, Talant, Spranger, Otto, Stelmach, Raphael, Strandberg, Timo, Sunyer, Jordi, Thijs, C., Todo Bom, Ana Maria, Triggiani, Massimo, Valenta, Rudolf, Valero, Antonio L., Van Hage, Marianne, Vandenplas, Olivier, Vezzani, Giorgio, Vichyanond, Pakit, Viegi, Giovanni, Wagenmann, Martin, Wahn, Ulrich, De Yun, Wang, Williams, D. M., Wright, John, Yawn, Barbara P., Yiallouros, P. K., Yusuf, Osman M., Zar, Heather J., Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Bousquet, Jean, Schünemann, Holger J., Hellings, Peter W., Arnavielhe, Sylvie, Bachert, Claus, Bedbrook, Anna, Bergmann, Karl Christian, Bosnic Anticevitch, Sinthia, Brozek, Jan L., Calderón, Moisés, Canonica, G. Walter, Casale, Thomas B., Chavannes, Niels H., Cox, Linda, Chrystyn, Henry, Cruz, Álvaro A., Dahl, Ronald, De Carlo, Giuseppe, Demoly, Pascal, Devillier, Phillipe, Dray, Gérard, Fletcher, Monica, Fokkens, Wytske J., Fonseca, Joao A., González Díaz, Sandra Nora, Grouse, Lawrence, Keil, Thomas, Kuna, Piotr, Larenas Linnemann, Désirée, Lodrup Carlsen, Karin C., Meltzer, E. O., Mullol, Jaoquim, Muraro, Antonella, Naclerio, Robert N., Palkonen, Susanna, Papadopoulos, Nikolaos G., Passalacqua, Giovanni, Price, David, Ryan, Dermot, Samolinski, Boleslaw, Scadding, Glenis K., Sheikh, Aziz, Spertini, François, Valiulis, Arunas, Valovirta, Erkka, Walker, Samantha, Wickman, Magnus, Yorgancioglu, Arzu, Haahtela, Tari, Zuberbier, Torsten, Aberer, Werner, Adachi, Mitsuru, Agache, Ioana, Akdis, Cezmi, Akdis, Mubeccel, Annesi Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Arshad, S. Hasan, Baiardini, Ilaria, Baigenzhin, Abay K., Barbara, Cristina, Bateman, Eric D., Beghé, Bianca, Bel, Elisabeth H., Ben Kheder, Ali, Bennoor, Kazi S., Benson, Michael, Bernstein, David, Michael, Bewick, Thomas, Bieber, Bindslev Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe A., Bousquet, Philippe J., Braido, Fulvio, Briggs, Andrew H., Brightling, Christopher E., Buhl, Roland, Burney, Peter G., Bush, Andrew, Caballero Fonseca, Fernando, Caimmi, Davide P., Camargos, Paulo, Camuzat, Thierry, Carlsen, Kai Hakon, Carr, Warner, Sarabia, Alfonso Cepeda, Chatzi, Leda, Chen, Yuzhi Z., Chiron, Raphaël, Chkhartishvili, Ekaterine, Chuchalin, Alexander G., Ciprandi, Georgio, Cirule, Ieva, Correia de Sousa, Jaime, Costa, David, Crooks, George, Custovic, Adnan, Dahlen, Sven Erik, Darsow, Ulf, De Blay, Frédéric, De Manuel Keenoy, Esteban, Dedeu, Tony, Deleanu, Diana, Denburg, Judah, Didier, Alain, Dinh Xuan, Anh Tuan, Dokic, Dejan, Douagui, Habib B., Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark S., El Gamal, Yehia, Emuzyte, Regina, Fink Wagner, Antje H., Fiocchi, Alessandro, Forastiere, Francesco, Gamkrelidze, Amiran, Gemicioğlu, Bilun, Gereda, José E., Gerth van Wijk, Roy, Gotua, Maia, Grisle, Ineta, Guzmán, M. Antonieta, Heinrich, Joachim, Hellquist Dahl, Birthe, Horak, Friedrich, Howarth, Peter H., Humbert, Marc, Hyland, Michael, Ivancevich, Juan Carlos, Jares, Edgardo José, Johnston, Sebastian L., Jonquet, Olivier, Joos, Guy, Jung, Ki Suck, Just, Jocelyne, Jutel, Marek, Kaidashev, Igor P., Khaitov, Musa R., Kalayci, Omer, Kalyoncu, Fuat, Keith, Paul K., Khaltaev, Nikolai, Kleine Tebbe, Jorg, Klimek, Ludger, N'Goran, Bernard Koffi, Kolek, Vítězslav, Koppelman, Gerard H., Kowalski, Marek, Kull, Inger, Kvedariene, Violeta, Lambrecht, Bart, Lau, Susanne, Laune, Daniel, Le Thi Tuyet, Lan, Li, Jingmei, Lieberman, Phillipe, Lipworth, Brian J., Renaud, Louis, Magard, Yves, Magnan, Antoine, Mahboub, Bassam, Majer, Ivan, Makela, Mika, Manning, Peter J., Masjedi, Mohamad R., Maurer, Marcus, Mavale Manuel, Sandra, Melén, Erik, Melo Gomes, Elisabete, Mercier, Jacques, Merk, Hans, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, Yousser, Molimard, Mathieu, Momas, Isabelle, Montilla Santana, Anna, Morais Almeida, Mario, Mösges, Ralph, Nadif, Rachel, Namazova Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Niggemann, Bodo, Nyembue, T. Dieudonné, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kim, Ouedraogo, Solange, Paggiaro, Pier Luigi, Pali Schöll, Isabella, Palmer, Stephen, Panzner, Petr, Papi, Alberto, Park, Hae-Sim, Pavord, Ian, Pawankar, Ruby, Pfaar, Oliver, Picard, Robert, Pigearias, Bernard, Pin, Isabelle, Plavec, Davor, Pohl, Wolfgang, Popov, Todor A., Postma, Dirkje S., Potter, Paul, Poulsen, Lars K., Rabe, Klaus F., Raciborski, Filip, Pontal, Françoise Radier, Reitamo, Sakari, Repka Ramírez, Maria Susana, Robalo Cordeiro, Carlos, Roberts, Graham, Rodenas, Francisco, Rolland, Christine, Rodriguez, Miguel Roman, Romano, Antonino, Rosado Pinto, José, Rosario, Nelson A., Rosenwasser, Larry, Rottem, Menachem, Sánchez Borges, Mario, Sastre Dominguez, Joaquim, Schmid Grendelmeier, Peter, Serrano, Eli, Simons, F. Estelle R., Sisul Alvariza, Juan Carlos, Skrindo, Ingebjorg, Smit, Henriette A., Solé, Dirceu, Sooronbaev, Talant, Spranger, Otto, Stelmach, Raphael, Strandberg, Timo, Sunyer, Jordi, Thijs, C., Todo Bom, Ana Maria, Triggiani, Massimo, Valenta, Rudolf, Valero, Antonio L., Van Hage, Marianne, Vandenplas, Olivier, Vezzani, Giorgio, Vichyanond, Pakit, Viegi, Giovanni, Wagenmann, Martin, Wahn, Ulrich, De Yun, Wang, Williams, D. M., Wright, John, Yawn, Barbara P., Yiallouros, P. K., Yusuf, Osman M., Zar, Heather J., Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, and Zidarn, Mihaela

Published
2016

197. Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Author

Bousquet, Jean, Farrell, J., Crooks, George, Hellings, Peter W., Bel, Elisabeth H., Bewick, M., Chavannes, Niels H., Correia de Sousa, J., Cruz, A. A., Haahtela, Tari, Joos, Guy, Khaltaev, Nikolai, Malva, J., Muraro, Antonella, Nogues, M., Palkonen, Susanna, Pedersen, S., Robalo Cordeiro, Carlos, Samolinski, Boleslaw, Strandberg, Timo, Valiulis, Arunas, Yorgancioglu, Arzu, Zuberbier, Torsten, Bedbrook, Anna, Aberer, Werner, Adachi, Mitsuru, Agusti, Alvar, Akdis, Cezmi, Akdis, Mubeccel, Ankri, J., Alonso, A., Annesi Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Arnavielhe, Sylvie, Arshad, S. Hasan, Bai, Chunxue, Baiardini, Ilaria, Bachert, Claus, Baigenzhin, Abay K., Barbara, Cristina, Bateman, Eric D., Beghé, Bianca, Kheder, A. Ben, Bennoor, Kazi S., Benson, Michael, Bergmann, Karl Christian, Bieber, T., Bindslev Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Blasi, F., Boner, A. L., Bonini, Matteo, Bonini, Sergio, Bosnic Anticevitch, Sinthia, Boulet, Louis Philippe, Bourret, Rodolphe A., Bousquet, Philippe J., Braido, Fulvio, Briggs, Andrew H., Brightling, Christopher E., Brozek, Jan L., Buhl, Roland, Burney, Peter G., Bush, Andrew, Caballero Fonseca, Fernando, Caimmi, Davide P., Calderon, M. A., Calverley, P. M., Camargos, P. A. M., Canonica, G. Walter, Camuzat, Thierry, Carlsen, Kai Hakon, Carr, Warner, Carriazo, A., Casale, Thomas B., Cepeda Sarabia, A. M., Chatzi, Leda, Chen, Yuzhi Z., Chiron, Raphaël, Chkhartishvili, Ekaterine, Chuchalin, Alexander G., Chung, K. F., Ciprandi, Georgio, Cirule, Ieva, Cox, Linda, Costa, D. J., Custovic, Adnan, Dahl, Ronald, Dahlen, Sven Erik, Darsow, Ulf, De Carlo, Giuseppe, De Blay, Frédéric, Dedeu, Tony, Deleanu, Diana, De Manuel Keenoy, Esteban, Demoly, Pascal, Denburg, J. A., Devillier, Phillipe, Didier, Alain, Dinh Xuan, Anh Tuan, Djukanovic, R., Dokic, D., Douagui, Habib B., Dray, Gérard, Dubakiene, Ruta, Durham, S. R., Dykewicz, Mark S., El Gamal, Yehia, Emuzyte, R., Fabbri, L. Muller, Fletcher, Monica, Fiocchi, Alessandro, Fink Wagner, Antje H., Fonseca, Joao A., Fokkens, Wytske J., Forastiere, Francesco, Frith, P., Gaga, M., Gamkrelidze, Amiran, Garcés, J., García Aymerich, J., Gemicioğlu, Bilun, Gereda, José E., González Díaz, Sandra Nora, Gotua, Maia, Grisle, Ineta, Grouse, Lawrence, Gutter, Z., Guzmán, M. Antonieta, Heaney, L. G., Hellquist Dahl, Birthe, Henderson, D., Hendry, A., Heinrich, Joachim, Heve, D., Horak, F., Hourihane, J. O’. B., Howarth, P., Humbert, Marc, Hyland, M. E., Illario, M., Ivancevich, Juan Carlos, Jardim, José R., Jares, Edgardo José, Jeandel, C., Jenkins, C., Johnston, Sebastian L., Jonquet, Olivier, Julge, K., Jung, Ki Suck, Just, Jocelyne, Kaidashev, Igor P., Khaitov, Musa R., Kalayci, Omer, Kalyoncu, A. F., Keil, Thomas, Keith, Paul K., Klimek, Ludger, Koffi N'Goran, B., Kolek, Vítězslav, Koppelman, Gerard H., Kowalski, M. L., Kull, Inger, Kuna, Piotr, Kvedariene, Violeta, Lambrecht, Bart, Lau, Susanne, Larenas Linnemann, Désirée, Laune, Daniel, Le, L. T. T., Lieberman, Phillipe, Lipworth, Brian J., Li, Jingmei, Lodrup Carlsen, Karin C., Louis, R., MacNee, W., Magard, Yves, Magnan, Antoine, Mahboub, Bassam, Mair, A., Majer, Ivan, Makela, M. J., Manning, Peter J., Mara, S., Marshall, G. D., Masjedi, Mohamad R., Matignon, P., Maurer, Marcus, Mavale Manuel, Sandra, Melén, Erik, Melo Gomes, Elisabete, Meltzer, E. O., Menzies Gow, A., Merk, Hans, Michel, J. P., Miculinic, N., Mihaltan, Florin, Milenkovic, Branislava, Mohammad, G. M. Y., Molimard, Mathieu, Momas, Isabelle, Montilla Santana, Anna, Morais Almeida, Mario, Morgan, M., Mösges, Ralph, Mullol, Jaoquim, Nafti, S., Namazova Baranova, Leyla, Naclerio, Robert N., Neou, Angelos, Neffen, Hugo, Nekam, Kristof, Niggemann, Bodo, Ninot, G., Nyembue, T. Dieudonné, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kim, Ouedraogo, Solange, Paggiaro, Pier Luigi, Pali Schöll, Isabella, Panzner, Petr, Papadopoulos, Nikolaos G., Papi, Alberto, Park, Hae-Sim, Passalacqua, Giovanni, Pavord, Ian, Pawankar, Ruby, Pengelly, R., Pfaar, Oliver, Picard, Robert, Pigearias, Bernard, Pin, Isabelle, Plavec, Davor, Poethig, D., Pohl, Wolfgang, Popov, Todor A., Portejoie, F., Potter, Paul, Postma, Dirkje S., Price, David, Rabe, Klaus F., Raciborski, Filip, Radier Pontal, F., Repka Ramirez, S., Reitamo, Sakari, Rennard, S., Rodenas, Francisco, Roberts, J., Roca, J., Rodriguez Mañas, L., Rolland, Christine, Roman Rodriguez, M., Romano, A., Rosado Pinto, José, Rosario, Nelson A., Rosenwasser, Lanny, Rottem, Menachem, Ryan, Dermot, Sánchez Borges, Mario, Scadding, Glenis K., Schünemann, Holger J., Serrano, Eli, Schmid Grendelmeier, Peter, Schulz, H., Sheikh, Aziz, Shields, M., Siafakas, N., Sibille, Y., Similowski, T., Simons, F. Estelle R., Sisul Alvariza, Juan Carlos, Skrindo, Ingebjorg, Smit, Henriette A., Solé, Dirceu, Sooronbaev, Talant, Spranger, Otto, Stelmach, Raphael, Sterk, P. J., Sunyer, Jordi, Thijs, C., To, Teresa, Todo Bom, Ana Maria, Triggiani, Massimo, Valenta, Rudolf, Valero, Antonio L., Valia, E., Valovirta, Erkka, Van Ganse, E., Van Hage, Marianne, Vandenplas, Olivier, Vasankari, T., Vellas, B., Vestbo, J., Vezzani, G., Vichyanond, Pakit, Viegi, Giovanni, Vogelmeier, C., Vontetsianos, T., Wagenmann, Martin, Wallaert, B., Walker, Samantha, Wang, D. Y., Wahn, Ulrich, Wickman, Magnus, Williams, D. M., Williams, S., Wright, John, Yawn, Barbara P., Yiallouros, P. K., Yusuf, Osman M., Zaidi, A., Zar, Heather J., Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Mercier, Jacques, Bousquet, Jean, Farrell, J., Crooks, George, Hellings, Peter W., Bel, Elisabeth H., Bewick, M., Chavannes, Niels H., Correia de Sousa, J., Cruz, A. A., Haahtela, Tari, Joos, Guy, Khaltaev, Nikolai, Malva, J., Muraro, Antonella, Nogues, M., Palkonen, Susanna, Pedersen, S., Robalo Cordeiro, Carlos, Samolinski, Boleslaw, Strandberg, Timo, Valiulis, Arunas, Yorgancioglu, Arzu, Zuberbier, Torsten, Bedbrook, Anna, Aberer, Werner, Adachi, Mitsuru, Agusti, Alvar, Akdis, Cezmi, Akdis, Mubeccel, Ankri, J., Alonso, A., Annesi Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Arnavielhe, Sylvie, Arshad, S. Hasan, Bai, Chunxue, Baiardini, Ilaria, Bachert, Claus, Baigenzhin, Abay K., Barbara, Cristina, Bateman, Eric D., Beghé, Bianca, Kheder, A. Ben, Bennoor, Kazi S., Benson, Michael, Bergmann, Karl Christian, Bieber, T., Bindslev Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Blasi, F., Boner, A. L., Bonini, Matteo, Bonini, Sergio, Bosnic Anticevitch, Sinthia, Boulet, Louis Philippe, Bourret, Rodolphe A., Bousquet, Philippe J., Braido, Fulvio, Briggs, Andrew H., Brightling, Christopher E., Brozek, Jan L., Buhl, Roland, Burney, Peter G., Bush, Andrew, Caballero Fonseca, Fernando, Caimmi, Davide P., Calderon, M. A., Calverley, P. M., Camargos, P. A. M., Canonica, G. Walter, Camuzat, Thierry, Carlsen, Kai Hakon, Carr, Warner, Carriazo, A., Casale, Thomas B., Cepeda Sarabia, A. M., Chatzi, Leda, Chen, Yuzhi Z., Chiron, Raphaël, Chkhartishvili, Ekaterine, Chuchalin, Alexander G., Chung, K. F., Ciprandi, Georgio, Cirule, Ieva, Cox, Linda, Costa, D. J., Custovic, Adnan, Dahl, Ronald, Dahlen, Sven Erik, Darsow, Ulf, De Carlo, Giuseppe, De Blay, Frédéric, Dedeu, Tony, Deleanu, Diana, De Manuel Keenoy, Esteban, Demoly, Pascal, Denburg, J. A., Devillier, Phillipe, Didier, Alain, Dinh Xuan, Anh Tuan, Djukanovic, R., Dokic, D., Douagui, Habib B., Dray, Gérard, Dubakiene, Ruta, Durham, S. R., Dykewicz, Mark S., El Gamal, Yehia, Emuzyte, R., Fabbri, L. Muller, Fletcher, Monica, Fiocchi, Alessandro, Fink Wagner, Antje H., Fonseca, Joao A., Fokkens, Wytske J., Forastiere, Francesco, Frith, P., Gaga, M., Gamkrelidze, Amiran, Garcés, J., García Aymerich, J., Gemicioğlu, Bilun, Gereda, José E., González Díaz, Sandra Nora, Gotua, Maia, Grisle, Ineta, Grouse, Lawrence, Gutter, Z., Guzmán, M. Antonieta, Heaney, L. G., Hellquist Dahl, Birthe, Henderson, D., Hendry, A., Heinrich, Joachim, Heve, D., Horak, F., Hourihane, J. O’. B., Howarth, P., Humbert, Marc, Hyland, M. E., Illario, M., Ivancevich, Juan Carlos, Jardim, José R., Jares, Edgardo José, Jeandel, C., Jenkins, C., Johnston, Sebastian L., Jonquet, Olivier, Julge, K., Jung, Ki Suck, Just, Jocelyne, Kaidashev, Igor P., Khaitov, Musa R., Kalayci, Omer, Kalyoncu, A. F., Keil, Thomas, Keith, Paul K., Klimek, Ludger, Koffi N'Goran, B., Kolek, Vítězslav, Koppelman, Gerard H., Kowalski, M. L., Kull, Inger, Kuna, Piotr, Kvedariene, Violeta, Lambrecht, Bart, Lau, Susanne, Larenas Linnemann, Désirée, Laune, Daniel, Le, L. T. T., Lieberman, Phillipe, Lipworth, Brian J., Li, Jingmei, Lodrup Carlsen, Karin C., Louis, R., MacNee, W., Magard, Yves, Magnan, Antoine, Mahboub, Bassam, Mair, A., Majer, Ivan, Makela, M. J., Manning, Peter J., Mara, S., Marshall, G. D., Masjedi, Mohamad R., Matignon, P., Maurer, Marcus, Mavale Manuel, Sandra, Melén, Erik, Melo Gomes, Elisabete, Meltzer, E. O., Menzies Gow, A., Merk, Hans, Michel, J. P., Miculinic, N., Mihaltan, Florin, Milenkovic, Branislava, Mohammad, G. M. Y., Molimard, Mathieu, Momas, Isabelle, Montilla Santana, Anna, Morais Almeida, Mario, Morgan, M., Mösges, Ralph, Mullol, Jaoquim, Nafti, S., Namazova Baranova, Leyla, Naclerio, Robert N., Neou, Angelos, Neffen, Hugo, Nekam, Kristof, Niggemann, Bodo, Ninot, G., Nyembue, T. Dieudonné, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kim, Ouedraogo, Solange, Paggiaro, Pier Luigi, Pali Schöll, Isabella, Panzner, Petr, Papadopoulos, Nikolaos G., Papi, Alberto, Park, Hae-Sim, Passalacqua, Giovanni, Pavord, Ian, Pawankar, Ruby, Pengelly, R., Pfaar, Oliver, Picard, Robert, Pigearias, Bernard, Pin, Isabelle, Plavec, Davor, Poethig, D., Pohl, Wolfgang, Popov, Todor A., Portejoie, F., Potter, Paul, Postma, Dirkje S., Price, David, Rabe, Klaus F., Raciborski, Filip, Radier Pontal, F., Repka Ramirez, S., Reitamo, Sakari, Rennard, S., Rodenas, Francisco, Roberts, J., Roca, J., Rodriguez Mañas, L., Rolland, Christine, Roman Rodriguez, M., Romano, A., Rosado Pinto, José, Rosario, Nelson A., Rosenwasser, Lanny, Rottem, Menachem, Ryan, Dermot, Sánchez Borges, Mario, Scadding, Glenis K., Schünemann, Holger J., Serrano, Eli, Schmid Grendelmeier, Peter, Schulz, H., Sheikh, Aziz, Shields, M., Siafakas, N., Sibille, Y., Similowski, T., Simons, F. Estelle R., Sisul Alvariza, Juan Carlos, Skrindo, Ingebjorg, Smit, Henriette A., Solé, Dirceu, Sooronbaev, Talant, Spranger, Otto, Stelmach, Raphael, Sterk, P. J., Sunyer, Jordi, Thijs, C., To, Teresa, Todo Bom, Ana Maria, Triggiani, Massimo, Valenta, Rudolf, Valero, Antonio L., Valia, E., Valovirta, Erkka, Van Ganse, E., Van Hage, Marianne, Vandenplas, Olivier, Vasankari, T., Vellas, B., Vestbo, J., Vezzani, G., Vichyanond, Pakit, Viegi, Giovanni, Vogelmeier, C., Vontetsianos, T., Wagenmann, Martin, Wallaert, B., Walker, Samantha, Wang, D. Y., Wahn, Ulrich, Wickman, Magnus, Williams, D. M., Williams, S., Wright, John, Yawn, Barbara P., Yiallouros, P. K., Yusuf, Osman M., Zaidi, A., Zar, Heather J., Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, and Mercier, Jacques

Published
2016

198. Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Author

Bousquet, Jean J., Farrell, J., Crooks, George, Hellings, Peter W., Bel, Elisabeth H., Bewick, M., Chavannes, Niels H., Correia de Sousa, Jaime, Cruz, A. A., Haahtela, Tari, Joos, Guy, Khaltaev, Nikolai, Malva, J., Muraro, Antonella, Nogues, M., Palkonen, Susanna, Pedersen, S., Robalo Cordeiro, Carlos, Samolinski, Boleslaw, Strandberg, Timo, Valiulis, Arunas, Yorgancioglu, Arzu, Zuberbier, Torsten, Bedbrook, Anna, Aberer, Werner, Adachi, Mitsuru, Agusti, Alvar, Akdis, Cezmi, Akdis, Mubeccel, Ankri, J., Alonso, A., Annesi Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Arnavielhe, Sylvie, Arshad, S. Hasan, Bai, Chunxue, Baiardini, Ilaria, Bachert, Claus, Baigenzhin, Abay K., Barbara, Cristina, Bateman, Eric D., Beghé, Bianca, Kheder, A. Ben, Bennoor, Kazi S., Benson, Michael, Bergmann, Karl Christian, Bieber, T., Bindslev Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Blasi, F., Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosnic Anticevitch, Sinthia, Boulet, Louis Philippe, Bourret, Rodolphe A., Bousquet, Philippe J., Braido, Fulvio, Briggs, Andrew H., Brightling, Christopher E., Brozek, Jan L., Buhl, Roland, Burney, Peter G., Bush, Andrew, Caballero Fonseca, Fernando, Caimmi, Davide P., Calderon, M. A., Calverley, P. M., Camargos, P. A. M., Canonica, Giorgio Walter, Camuzat, Thierry, Carlsen, Kai Hakon, Carr, Warner, Carriazo, A., Casale, Thomas B., Cepeda Sarabia, A. M., Chatzi, Leda, Chen, Yuzhi Z., Chiron, Raphaël, Chkhartishvili, Ekaterine, Chuchalin, Alexander G., Chung, K. F., Ciprandi, Georgio, Cirule, Ieva, Cox, Linda, Costa, David J., Custovic, Adnan, Dahl, Ronald, Dahlen, Sven Erik, Darsow, Ulf, De Carlo, Giuseppe, De Blay, Frédéric, Dedeu, Tony, Deleanu, Diana, De Manuel Keenoy, Esteban, Demoly, Pascal, Denburg, J. A., Devillier, Phillipe, Didier, Alain, Dinh Xuan, Anh Tuan, Djukanovic, R., Dokic, Dejan, Douagui, Habib B., Dray, Gérard, Dubakiene, Ruta, Durham, S. R., Dykewicz, Mark S., El Gamal, Yehia, Emuzyte, R., Fabbri, L. Muller, Fletcher, Monica, Fiocchi, Alessandro, Fink Wagner, Antje H., Fonseca, Joao A., Fokkens, Wytske J., Forastiere, Francesco, Frith, P., Gaga, M., Gamkrelidze, Amiran, Garcés, J., García Aymerich, J., Gemicioğlu, Bilun, Gereda, José E., González Díaz, Sandra Nora, Gotua, Maia, Grisle, Ineta, Grouse, Lawrence, Gutter, Z., Guzmán Meléndez, María Antonieta, Heaney, L. G., Hellquist Dahl, Birthe, Henderson, D., Hendry, A., Heinrich, Joachim, Heve, D., Horak, Friedrich, Hourihane, J. O’. B., Howarth, Peter H., Humbert, Marc, Hyland, Michael E., Illario, M., Ivancevich, Juan Carlos, Jardim, José R., Jares, Edgardo José, Jeandel, C., Jenkins, C., Johnston, Sebastian L., Jonquet, Olivier, Julge, K., Jung, Ki Suck, Just, Jocelyne, Kaidashev, Igor P., Khaitov, Musa R., Kalayci, Omer, Kalyoncu, A. F., Keil, Thomas, Keith, Paul K., Klimek, Ludger, Koffi N'Goran, B., Kolek, Vítězslav, Koppelman, Gerard H., Kowalski, Marek L., Kull, Inger, Kuna, Piotr, Kvedariene, Violeta, Lambrecht, Bart, Lau, Susanne, Larenas Linnemann, Désirée, Laune, Daniel, Le, L. T. T., Lieberman, Phillipe, Lipworth, Brian J., Li, Jingmei, Lodrup Carlsen, Karin C., Louis, R., MacNee, W., Magard, Yves, Magnan, Antoine, Mahboub, Bassam, Mair, A., Majer, Ivan, Makela, M. J., Manning, Peter J., Mara, S., Marshall, G. D., Masjedi, Mohamad R., Matignon, P., Maurer, Marcus, Mavale Manuel, Sandra, Melén, Erik, Melo Gomes, Elisabete, Meltzer, E. O., Menzies Gow, A., Merk, Hans, Michel, J. P., Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, G. M. Y., Molimard, Mathieu, Momas, Isabelle, Montilla Santana, Anna, Morais Almeida, Mario, Morgan, M., Mösges, Ralph, Mullol, Jaoquim, Nafti, S., Namazova Baranova, Leyla, Naclerio, Robert N., Neou, Angelos, Neffen, Hugo, Nekam, Kristof, Niggemann, Bodo, Ninot, G., Nyembue, T. Dieudonné, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kim, Ouedraogo, Solange, Paggiaro, Pier Luigi, Pali Schöll, Isabella, Panzner, Petr, Papadopoulos, Nikolaos G., Papi, Alberto, Park, Hae-Sim, Passalacqua, Giovanni, Pavord, Ian, Pawankar, Ruby, Pengelly, R., Pfaar, Oliver, Picard, Robert, Pigearias, Bernard, Pin, Isabelle, Plavec, Davor, Poethig, D., Pohl, Wolfgang, Popov, Todor A., Portejoie, F., Potter, Paul, Postma, Dirkje S., Price, David, Rabe, Klaus F., Raciborski, Filip, Radier Pontal, F., Repka Ramírez, Maria Susana, Reitamo, Sakari, Rennard, S., Rodenas, Francisco, Roberts, J., Roca, J., Rodriguez Mañas, L., Rolland, Christine, Roman Rodriguez, M., Romano, A., Rosado Pinto, José, Rosario, Nelson A., Rosenwasser, Lanny, Rottem, Menachem, Ryan, Dermot, Sánchez Borges, Mario, Scadding, Glenis K., Schünemann, Holger J., Serrano, Eli, Schmid Grendelmeier, Peter, Schulz, H., Sheikh, Aziz, Shields, M., Siafakas, N., Sibille, Y., Similowski, T., Simons, F. Estelle R., Sisul Alvariza, Juan Carlos, Skrindo, Ingebjorg, Smit, Henriette A., Solé, Dirceu, Sooronbaev, Talant, Spranger, Otto, Stelmach, Raphael, Sterk, P. J., Sunyer, Jordi, Thijs, C., To, Teresa, Todo Bom, Ana Maria, Triggiani, Massimo, Valenta, Rudolf, Valero, Antonio L., Valia, E., Valovirta, Erkka, Van Ganse, E., Van Hage, Marianne, Vandenplas, Olivier, Vasankari, T., Vellas, B., Vestbo, J., Vezzani, Giorgio, Vichyanond, Pakit, Viegi, Giovanni, Vogelmeier, C., Vontetsianos, T., Wagenmann, Martin, Wallaert, B., Walker, Samantha, Wang, D. Y., Wahn, Ulrich, Wickman, Magnus, Williams, D. M., Williams, S., Wright, John, Yawn, Barbara P., Yiallouros, P. K., Yusuf, Osman M., Zaidi, A., Zar, Heather J., Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Mercier, Jacques, Bousquet, Jean J., Farrell, J., Crooks, George, Hellings, Peter W., Bel, Elisabeth H., Bewick, M., Chavannes, Niels H., Correia de Sousa, Jaime, Cruz, A. A., Haahtela, Tari, Joos, Guy, Khaltaev, Nikolai, Malva, J., Muraro, Antonella, Nogues, M., Palkonen, Susanna, Pedersen, S., Robalo Cordeiro, Carlos, Samolinski, Boleslaw, Strandberg, Timo, Valiulis, Arunas, Yorgancioglu, Arzu, Zuberbier, Torsten, Bedbrook, Anna, Aberer, Werner, Adachi, Mitsuru, Agusti, Alvar, Akdis, Cezmi, Akdis, Mubeccel, Ankri, J., Alonso, A., Annesi Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Arnavielhe, Sylvie, Arshad, S. Hasan, Bai, Chunxue, Baiardini, Ilaria, Bachert, Claus, Baigenzhin, Abay K., Barbara, Cristina, Bateman, Eric D., Beghé, Bianca, Kheder, A. Ben, Bennoor, Kazi S., Benson, Michael, Bergmann, Karl Christian, Bieber, T., Bindslev Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Blasi, F., Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosnic Anticevitch, Sinthia, Boulet, Louis Philippe, Bourret, Rodolphe A., Bousquet, Philippe J., Braido, Fulvio, Briggs, Andrew H., Brightling, Christopher E., Brozek, Jan L., Buhl, Roland, Burney, Peter G., Bush, Andrew, Caballero Fonseca, Fernando, Caimmi, Davide P., Calderon, M. A., Calverley, P. M., Camargos, P. A. M., Canonica, Giorgio Walter, Camuzat, Thierry, Carlsen, Kai Hakon, Carr, Warner, Carriazo, A., Casale, Thomas B., Cepeda Sarabia, A. M., Chatzi, Leda, Chen, Yuzhi Z., Chiron, Raphaël, Chkhartishvili, Ekaterine, Chuchalin, Alexander G., Chung, K. F., Ciprandi, Georgio, Cirule, Ieva, Cox, Linda, Costa, David J., Custovic, Adnan, Dahl, Ronald, Dahlen, Sven Erik, Darsow, Ulf, De Carlo, Giuseppe, De Blay, Frédéric, Dedeu, Tony, Deleanu, Diana, De Manuel Keenoy, Esteban, Demoly, Pascal, Denburg, J. A., Devillier, Phillipe, Didier, Alain, Dinh Xuan, Anh Tuan, Djukanovic, R., Dokic, Dejan, Douagui, Habib B., Dray, Gérard, Dubakiene, Ruta, Durham, S. R., Dykewicz, Mark S., El Gamal, Yehia, Emuzyte, R., Fabbri, L. Muller, Fletcher, Monica, Fiocchi, Alessandro, Fink Wagner, Antje H., Fonseca, Joao A., Fokkens, Wytske J., Forastiere, Francesco, Frith, P., Gaga, M., Gamkrelidze, Amiran, Garcés, J., García Aymerich, J., Gemicioğlu, Bilun, Gereda, José E., González Díaz, Sandra Nora, Gotua, Maia, Grisle, Ineta, Grouse, Lawrence, Gutter, Z., Guzmán Meléndez, María Antonieta, Heaney, L. G., Hellquist Dahl, Birthe, Henderson, D., Hendry, A., Heinrich, Joachim, Heve, D., Horak, Friedrich, Hourihane, J. O’. B., Howarth, Peter H., Humbert, Marc, Hyland, Michael E., Illario, M., Ivancevich, Juan Carlos, Jardim, José R., Jares, Edgardo José, Jeandel, C., Jenkins, C., Johnston, Sebastian L., Jonquet, Olivier, Julge, K., Jung, Ki Suck, Just, Jocelyne, Kaidashev, Igor P., Khaitov, Musa R., Kalayci, Omer, Kalyoncu, A. F., Keil, Thomas, Keith, Paul K., Klimek, Ludger, Koffi N'Goran, B., Kolek, Vítězslav, Koppelman, Gerard H., Kowalski, Marek L., Kull, Inger, Kuna, Piotr, Kvedariene, Violeta, Lambrecht, Bart, Lau, Susanne, Larenas Linnemann, Désirée, Laune, Daniel, Le, L. T. T., Lieberman, Phillipe, Lipworth, Brian J., Li, Jingmei, Lodrup Carlsen, Karin C., Louis, R., MacNee, W., Magard, Yves, Magnan, Antoine, Mahboub, Bassam, Mair, A., Majer, Ivan, Makela, M. J., Manning, Peter J., Mara, S., Marshall, G. D., Masjedi, Mohamad R., Matignon, P., Maurer, Marcus, Mavale Manuel, Sandra, Melén, Erik, Melo Gomes, Elisabete, Meltzer, E. O., Menzies Gow, A., Merk, Hans, Michel, J. P., Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, G. M. Y., Molimard, Mathieu, Momas, Isabelle, Montilla Santana, Anna, Morais Almeida, Mario, Morgan, M., Mösges, Ralph, Mullol, Jaoquim, Nafti, S., Namazova Baranova, Leyla, Naclerio, Robert N., Neou, Angelos, Neffen, Hugo, Nekam, Kristof, Niggemann, Bodo, Ninot, G., Nyembue, T. Dieudonné, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kim, Ouedraogo, Solange, Paggiaro, Pier Luigi, Pali Schöll, Isabella, Panzner, Petr, Papadopoulos, Nikolaos G., Papi, Alberto, Park, Hae-Sim, Passalacqua, Giovanni, Pavord, Ian, Pawankar, Ruby, Pengelly, R., Pfaar, Oliver, Picard, Robert, Pigearias, Bernard, Pin, Isabelle, Plavec, Davor, Poethig, D., Pohl, Wolfgang, Popov, Todor A., Portejoie, F., Potter, Paul, Postma, Dirkje S., Price, David, Rabe, Klaus F., Raciborski, Filip, Radier Pontal, F., Repka Ramírez, Maria Susana, Reitamo, Sakari, Rennard, S., Rodenas, Francisco, Roberts, J., Roca, J., Rodriguez Mañas, L., Rolland, Christine, Roman Rodriguez, M., Romano, A., Rosado Pinto, José, Rosario, Nelson A., Rosenwasser, Lanny, Rottem, Menachem, Ryan, Dermot, Sánchez Borges, Mario, Scadding, Glenis K., Schünemann, Holger J., Serrano, Eli, Schmid Grendelmeier, Peter, Schulz, H., Sheikh, Aziz, Shields, M., Siafakas, N., Sibille, Y., Similowski, T., Simons, F. Estelle R., Sisul Alvariza, Juan Carlos, Skrindo, Ingebjorg, Smit, Henriette A., Solé, Dirceu, Sooronbaev, Talant, Spranger, Otto, Stelmach, Raphael, Sterk, P. J., Sunyer, Jordi, Thijs, C., To, Teresa, Todo Bom, Ana Maria, Triggiani, Massimo, Valenta, Rudolf, Valero, Antonio L., Valia, E., Valovirta, Erkka, Van Ganse, E., Van Hage, Marianne, Vandenplas, Olivier, Vasankari, T., Vellas, B., Vestbo, J., Vezzani, Giorgio, Vichyanond, Pakit, Viegi, Giovanni, Vogelmeier, C., Vontetsianos, T., Wagenmann, Martin, Wallaert, B., Walker, Samantha, Wang, D. Y., Wahn, Ulrich, Wickman, Magnus, Williams, D. M., Williams, S., Wright, John, Yawn, Barbara P., Yiallouros, P. K., Yusuf, Osman M., Zaidi, A., Zar, Heather J., Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, and Mercier, Jacques

Published
2016

199. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis

Author

Bousquet, Jean J., Schünemann, Holger J., Hellings, Peter W., Arnavielhe, Sylvie, Bachert, Claus, Bedbrook, Anna, Bergmann, Karl Christian, Bosnic Anticevitch, Sinthia, Brozek, Jan L., Calderón, Moisés, Canonica, Giorgio Walter, Casale, Thomas B., Chavannes, Niels H., Cox, Linda, Chrystyn, Henry, Cruz, Álvaro A., Dahl, Ronald, De Carlo, Giuseppe, Demoly, Pascal, Devillier, Phillipe, Dray, Gérard, Fletcher, Monica, Fokkens, Wytske J., Fonseca, Joao A., González Díaz, Sandra Nora, Grouse, Lawrence, Keil, Thomas, Kuna, Piotr, Larenas Linnemann, Désirée, Lodrup Carlsen, Karin C., Meltzer, E. O., Mullol, Jaoquim, Muraro, Antonella, Naclerio, Robert N., Palkonen, Susanna, Papadopoulos, Nikolaos G., Passalacqua, Giovanni, Price, David, Ryan, Dermot, Samolinski, Boleslaw, Scadding, Glenis K., Sheikh, Aziz, Spertini, François, Valiulis, Arunas, Valovirta, Erkka, Walker, Samantha, Wickman, Magnus, Yorgancioglu, Arzu, Haahtela, Tari, Zuberbier, Torsten, Aberer, Werner, Adachi, Mitsuru, Agache, Ioana, Akdis, Cezmi, Akdis, Mubeccel, Annesi Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Arshad, S. Hasan, Baiardini, Ilaria, Baigenzhin, Abay K., Barbara, Cristina, Bateman, Eric D., Beghé, Bianca, Bel, Elisabeth H., Ben Kheder, Ali, Bennoor, Kazi S., Benson, Michael, Bernstein, David, Michael, Bewick, Thomas, Bieber, Bindslev Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe A., Bousquet, Philippe J., Braido, Fulvio, Briggs, Andrew H., Brightling, Christopher E., Buhl, Roland, Burney, Peter G., Bush, Andrew, Caballero Fonseca, Fernando, Caimmi, Davide P., Camargos, Paulo, Camuzat, Thierry, Carlsen, Kai Hakon, Carr, Warner, Sarabia, Alfonso Cepeda, Chatzi, Leda, Chen, Yuzhi Z., Chiron, Raphaël, Chkhartishvili, Ekaterine, Chuchalin, Alexander G., Ciprandi, Georgio, Cirule, Ieva, Correia de Sousa, Jaime, Costa, David J., Crooks, George, Custovic, Adnan, Dahlen, Sven Erik, Darsow, Ulf, De Blay, Frédéric, De Manuel Keenoy, Esteban, Dedeu, Tony, Deleanu, Diana, Denburg, Judah, Didier, Alain, Dinh Xuan, Anh Tuan, Dokic, Dejan, Douagui, Habib B., Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark S., El Gamal, Yehia, Emuzyte, Regina, Fink Wagner, Antje H., Fiocchi, Alessandro, Forastiere, Francesco, Gamkrelidze, Amiran, Gemicioğlu, Bilun, Gereda, José E., Gerth van Wijk, Roy, Gotua, Maia, Grisle, Ineta, Guzmán Meléndez, María Antonieta, Heinrich, Joachim, Hellquist Dahl, Birthe, Horak, Friedrich, Howarth, Peter H., Humbert, Marc, Hyland, Michael E., Ivancevich, Juan Carlos, Jares, Edgardo José, Johnston, Sebastian L., Jonquet, Olivier, Joos, Guy, Jung, Ki Suck, Just, Jocelyne, Jutel, Marek, Kaidashev, Igor P., Khaitov, Musa R., Kalayci, Omer, Kalyoncu, Fuat, Keith, Paul K., Khaltaev, Nikolai, Kleine Tebbe, Jorg, Klimek, Ludger, N'Goran, Bernard Koffi, Kolek, Vítězslav, Koppelman, Gerard H., Kowalski, Marek L., Kull, Inger, Kvedariene, Violeta, Lambrecht, Bart, Lau, Susanne, Laune, Daniel, Le Thi Tuyet, Lan, Li, Jingmei, Lieberman, Phillipe, Lipworth, Brian J., Renaud, Louis, Magard, Yves, Magnan, Antoine, Mahboub, Bassam, Majer, Ivan, Makela, Mika, Manning, Peter J., Masjedi, Mohamad R., Maurer, Marcus, Mavale Manuel, Sandra, Melén, Erik, Melo Gomes, Elisabete, Mercier, Jacques, Merk, Hans, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, Yousser, Molimard, Mathieu, Momas, Isabelle, Montilla Santana, Anna, Morais Almeida, Mario, Mösges, Ralph, Nadif, Rachel, Namazova Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Niggemann, Bodo, Nyembue, T. Dieudonné, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kim, Ouedraogo, Solange, Paggiaro, Pier Luigi, Pali Schöll, Isabella, Palmer, Stephen, Panzner, Petr, Papi, Alberto, Park, Hae-Sim, Pavord, Ian, Pawankar, Ruby, Pfaar, Oliver, Picard, Robert, Pigearias, Bernard, Pin, Isabelle, Plavec, Davor, Pohl, Wolfgang, Popov, Todor A., Postma, Dirkje S., Potter, Paul, Poulsen, Lars K., Rabe, Klaus F., Raciborski, Filip, Pontal, Françoise Radier, Reitamo, Sakari, Repka Ramírez, Maria Susana, Robalo Cordeiro, Carlos, Roberts, Graham, Rodenas, Francisco, Rolland, Christine, Rodriguez, Miguel Roman, Romano, Antonino, Rosado Pinto, José, Rosario, Nelson A., Rosenwasser, Larry, Rottem, Menachem, Sánchez Borges, Mario, Sastre Dominguez, Joaquim, Schmid Grendelmeier, Peter, Serrano, Eli, Simons, F. Estelle R., Sisul Alvariza, Juan Carlos, Skrindo, Ingebjorg, Smit, Henriette A., Solé, Dirceu, Sooronbaev, Talant, Spranger, Otto, Stelmach, Raphael, Strandberg, Timo, Sunyer, Jordi, Thijs, C., Todo Bom, Ana Maria, Triggiani, Massimo, Valenta, Rudolf, Valero, Antonio L., Van Hage, Marianne, Vandenplas, Olivier, Vezzani, Giorgio, Vichyanond, Pakit, Viegi, Giovanni, Wagenmann, Martin, Wahn, Ulrich, De Yun, Wang, Williams, D. M., Wright, John, Yawn, Barbara P., Yiallouros, P. K., Yusuf, Osman M., Zar, Heather J., Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Bousquet, Jean J., Schünemann, Holger J., Hellings, Peter W., Arnavielhe, Sylvie, Bachert, Claus, Bedbrook, Anna, Bergmann, Karl Christian, Bosnic Anticevitch, Sinthia, Brozek, Jan L., Calderón, Moisés, Canonica, Giorgio Walter, Casale, Thomas B., Chavannes, Niels H., Cox, Linda, Chrystyn, Henry, Cruz, Álvaro A., Dahl, Ronald, De Carlo, Giuseppe, Demoly, Pascal, Devillier, Phillipe, Dray, Gérard, Fletcher, Monica, Fokkens, Wytske J., Fonseca, Joao A., González Díaz, Sandra Nora, Grouse, Lawrence, Keil, Thomas, Kuna, Piotr, Larenas Linnemann, Désirée, Lodrup Carlsen, Karin C., Meltzer, E. O., Mullol, Jaoquim, Muraro, Antonella, Naclerio, Robert N., Palkonen, Susanna, Papadopoulos, Nikolaos G., Passalacqua, Giovanni, Price, David, Ryan, Dermot, Samolinski, Boleslaw, Scadding, Glenis K., Sheikh, Aziz, Spertini, François, Valiulis, Arunas, Valovirta, Erkka, Walker, Samantha, Wickman, Magnus, Yorgancioglu, Arzu, Haahtela, Tari, Zuberbier, Torsten, Aberer, Werner, Adachi, Mitsuru, Agache, Ioana, Akdis, Cezmi, Akdis, Mubeccel, Annesi Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Arshad, S. Hasan, Baiardini, Ilaria, Baigenzhin, Abay K., Barbara, Cristina, Bateman, Eric D., Beghé, Bianca, Bel, Elisabeth H., Ben Kheder, Ali, Bennoor, Kazi S., Benson, Michael, Bernstein, David, Michael, Bewick, Thomas, Bieber, Bindslev Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe A., Bousquet, Philippe J., Braido, Fulvio, Briggs, Andrew H., Brightling, Christopher E., Buhl, Roland, Burney, Peter G., Bush, Andrew, Caballero Fonseca, Fernando, Caimmi, Davide P., Camargos, Paulo, Camuzat, Thierry, Carlsen, Kai Hakon, Carr, Warner, Sarabia, Alfonso Cepeda, Chatzi, Leda, Chen, Yuzhi Z., Chiron, Raphaël, Chkhartishvili, Ekaterine, Chuchalin, Alexander G., Ciprandi, Georgio, Cirule, Ieva, Correia de Sousa, Jaime, Costa, David J., Crooks, George, Custovic, Adnan, Dahlen, Sven Erik, Darsow, Ulf, De Blay, Frédéric, De Manuel Keenoy, Esteban, Dedeu, Tony, Deleanu, Diana, Denburg, Judah, Didier, Alain, Dinh Xuan, Anh Tuan, Dokic, Dejan, Douagui, Habib B., Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark S., El Gamal, Yehia, Emuzyte, Regina, Fink Wagner, Antje H., Fiocchi, Alessandro, Forastiere, Francesco, Gamkrelidze, Amiran, Gemicioğlu, Bilun, Gereda, José E., Gerth van Wijk, Roy, Gotua, Maia, Grisle, Ineta, Guzmán Meléndez, María Antonieta, Heinrich, Joachim, Hellquist Dahl, Birthe, Horak, Friedrich, Howarth, Peter H., Humbert, Marc, Hyland, Michael E., Ivancevich, Juan Carlos, Jares, Edgardo José, Johnston, Sebastian L., Jonquet, Olivier, Joos, Guy, Jung, Ki Suck, Just, Jocelyne, Jutel, Marek, Kaidashev, Igor P., Khaitov, Musa R., Kalayci, Omer, Kalyoncu, Fuat, Keith, Paul K., Khaltaev, Nikolai, Kleine Tebbe, Jorg, Klimek, Ludger, N'Goran, Bernard Koffi, Kolek, Vítězslav, Koppelman, Gerard H., Kowalski, Marek L., Kull, Inger, Kvedariene, Violeta, Lambrecht, Bart, Lau, Susanne, Laune, Daniel, Le Thi Tuyet, Lan, Li, Jingmei, Lieberman, Phillipe, Lipworth, Brian J., Renaud, Louis, Magard, Yves, Magnan, Antoine, Mahboub, Bassam, Majer, Ivan, Makela, Mika, Manning, Peter J., Masjedi, Mohamad R., Maurer, Marcus, Mavale Manuel, Sandra, Melén, Erik, Melo Gomes, Elisabete, Mercier, Jacques, Merk, Hans, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, Yousser, Molimard, Mathieu, Momas, Isabelle, Montilla Santana, Anna, Morais Almeida, Mario, Mösges, Ralph, Nadif, Rachel, Namazova Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Niggemann, Bodo, Nyembue, T. Dieudonné, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kim, Ouedraogo, Solange, Paggiaro, Pier Luigi, Pali Schöll, Isabella, Palmer, Stephen, Panzner, Petr, Papi, Alberto, Park, Hae-Sim, Pavord, Ian, Pawankar, Ruby, Pfaar, Oliver, Picard, Robert, Pigearias, Bernard, Pin, Isabelle, Plavec, Davor, Pohl, Wolfgang, Popov, Todor A., Postma, Dirkje S., Potter, Paul, Poulsen, Lars K., Rabe, Klaus F., Raciborski, Filip, Pontal, Françoise Radier, Reitamo, Sakari, Repka Ramírez, Maria Susana, Robalo Cordeiro, Carlos, Roberts, Graham, Rodenas, Francisco, Rolland, Christine, Rodriguez, Miguel Roman, Romano, Antonino, Rosado Pinto, José, Rosario, Nelson A., Rosenwasser, Larry, Rottem, Menachem, Sánchez Borges, Mario, Sastre Dominguez, Joaquim, Schmid Grendelmeier, Peter, Serrano, Eli, Simons, F. Estelle R., Sisul Alvariza, Juan Carlos, Skrindo, Ingebjorg, Smit, Henriette A., Solé, Dirceu, Sooronbaev, Talant, Spranger, Otto, Stelmach, Raphael, Strandberg, Timo, Sunyer, Jordi, Thijs, C., Todo Bom, Ana Maria, Triggiani, Massimo, Valenta, Rudolf, Valero, Antonio L., Van Hage, Marianne, Vandenplas, Olivier, Vezzani, Giorgio, Vichyanond, Pakit, Viegi, Giovanni, Wagenmann, Martin, Wahn, Ulrich, De Yun, Wang, Williams, D. M., Wright, John, Yawn, Barbara P., Yiallouros, P. K., Yusuf, Osman M., Zar, Heather J., Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, and Zidarn, Mihaela

Published
2016

200. Bronchial thermoplasty: a new therapeutic option for the treatment of severe, uncontrolled asthma in adults

Author

Dombret, Marie-Christine, Alagha, Khuder, Boulet, Louis Philippe, Brillet, Pierre Yves, Joos, Guy, Laviolette, Michel, Louis, Renaud, Rochat, Thierry, Gasche-Soccal, Paola Marina Alessandra, Aubier, Michel, and Chanez, Pascal

Subjects
ddc:616, Adult, Catheters, Adolescent, Patient Selection, Asthma/physiopathology/therapy, Middle Aged, Bronchi/physiopathology, Severity of Illness Index, respiratory tract diseases, Young Adult, Treatment Outcome, Bronchoscopy/adverse effects/instrumentation/methods, Hyperthermia, Induced/adverse effects/instrumentation/methods, Humans, Aged
Abstract

Bronchial thermoplasty is a young yet promising treatment for severe asthma whose benefit for long-term asthma control outweighs the short-term risk of deterioration and hospitalisation in the days following the treatment. It is an innovative treatment whose clinical efficacy and safety are beginning to be better understood. Since this is a device-based therapy, the overall evaluation of risk-benefit is unlike that of pharmaceutical products; safety aspects, regulatory requirements, study design and effect size assessment may be unfamiliar. The mechanisms of action and optimal patient selection need to be addressed in further rigorous clinical and scientific studies. Bronchial thermoplasty fits in perfectly with the movement to expand personalised medicine in the field of chronic airway disorders. This is a device-based complimentary asthma treatment that must be supported and developed in order to meet the unmet needs of modern severe asthma management. The mechanisms of action and the type of patients that benefit from bronchial thermoplasty are the most important challenges for bronchial thermoplasty in the future.

Published
2014

Catalog

Books, media, physical & digital resources
See catalog results