2,651 results on '"Jiang Hualiang"'
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152. Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists
153. Rational Design of Organelle-targeted Fluorescent Probes: Insights from Artificial Intelligence
154. Structural basis of peptide recognition and activation of endothelin receptors
155. PanGu Drug Model: learn a molecule like a human
156. The Human Ether-A-Go-Go–Related Gene Activator NS1643 Enhances Epilepsy-Associated KCNQ Channels
157. Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors
158. Design, synthesis and biological evaluation of novel 6-alkenylamides substituted of 4-anilinothieno[2,3-d]pyrimidines as irreversible epidermal growth factor receptor inhibitors
159. Design, synthesis and biological evaluation of hetero-aromatic moieties substituted pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors
160. Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase
161. Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma
162. Identification and Evaluation of Coronavirus Replicase Inhibitors Using a Replicon Cell Line
163. Structure and Dynamics of Sars Coronavirus Main Proteinase (MPRO)
164. Probing the structure and dynamics of caveolin-1 in a caveolae-mimicking asymmetric lipid bilayer model
165. FMRP phosphorylation modulates neuronal translation through YTHDF1
166. Increased Soluble Epoxide Hydrolase Activity Positively Correlates with Mortality in Heart Failure Patients with Preserved Ejection Fraction: Evidence from Metabolomics
167. Computationally Elucidating the Binding Kinetics for Different AChE Inhibitors to Access the Rationale for Improving the Drug Efficacy
168. High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors
169. Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor
170. Synthesis and biological evaluation of 2-amino-5-aryl-3-benzylthiopyridine scaffold based potent c-Met inhibitors
171. Computational methods for drug design and discovery: focus on China
172. Helix Unfolding/Refolding Characterizes the Functional Dynamics of Staphylococcus aureus Clp Protease
173. Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D1, D2 and serotonin 5-HT1A multi-action profile
174. Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: Binding mode, inhibitory mechanism and biological action
175. Oxidation-sensing Regulator AbfR Regulates Oxidative Stress Responses, Bacterial Aggregation, and Biofilm Formation in Staphylococcus epidermidis
176. Dynamic PIP 2 interactions with voltage sensor elements contribute to KCNQ2 channel gating
177. Structure of the CCR5 Chemokine Receptor—HIV Entry Inhibitor Maraviroc Complex
178. Structural Basis for Molecular Recognition at Serotonin Receptors
179. Free energy landscape for the binding process of Huperzine A to acetylcholinesterase
180. Structural insight into substrate preference for TET-mediated oxidation
181. Two disparate ligand-binding sites in the human P2[Y.sub.1] receptor
182. Selective Electrochemical Benzylic C(sp3)−H Oxidations in Fluoroalcohols.
183. Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase
184. Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance
185. Discovery of novel 2-aminopyridine-3-carboxamides as c-Met kinase inhibitors
186. Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA
187. Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: Selective inhibitors of dopamine D1 receptor
188. Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities
189. Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases
190. Natural products as a gold mine for selective matrix metalloproteinases inhibitors
191. A Theoretical Model for Calculating Voltage Sensitivity of Ion Channels and the Application on Kv1.2 Potassium Channel
192. Discovery of Small-Molecule Degraders of the CDK9-Cyclin T1 Complex for Targeting Transcriptional Addiction in Prostate Cancer
193. Universal mechanism of hormone and allosteric agonist mediated activation of glycoprotein hormone receptors as revealed by structures of follicle stimulating hormone receptor
194. Why is the SARS-CoV-2 Omicron variant milder?
195. Basis for antibody- and hormone-mediated activation of TSHR in Graves’ disease
196. L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression
197. Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial
198. Discovery of ARF1-targeting inhibitor demethylzeylasteral as a potential agent against breast cancer
199. Retraction Note: Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus
200. Computational characterization of transducer recognition of β2 adrenergic receptor
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