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Introduction: The Holocene mud deposits that extend from the Yangtze River mouth to the Taiwan Strait along the Zhejiang–Fujian coast, East China Sea (ECS), have attracted considerable research attention. However, there is a lack of consensus regarding the redistribution flux of Yangtze River sediment after it enters the sea. There are many bays along the Zhejiang and Fujian coasts, but their role in the source–sink process of Yangtze River sediment is not well-documented owing to limited data.Methods: In this study, data from shallow seismic profiles, core samples, and surface sediment samples were analysed to assess the role of Sanmen Bay, the second largest bay in Zhejiang Province, in the source–sink process of Yangtze River sediments.Results: The results showed that Sanmen Bay is an important sink for Yangtze River sediments. The characteristics of the clay minerals indicate that the fine-grained sediments in Sanmen Bay are mainly derived from Yangtze River sediments. The thickness of Holocene deposits in Sanmen Bay ranges from 8.2 to 32.0 m, with an average of 23.4 m and a total sediment volume of 5.06 × 104 Mt, accounting for 1% of Yangtze River sediment in this time period. The Bayesian age-depth model based on borehole accelerator mass spectrometry (AMS) 14C dating shows that a high sedimentation rate occurred in the early and late Holocene but decreased significantly in the mid-Holocene, which is similar to that of the inner shelf of the East China Sea (ECS).Conclusion: The variation in the Holocene sedimentation rate in Sanmen Bay is related to the southward transport process and mechanism of Yangtze River sediments. The results of this study provide a basis for understanding the source–sink process of sediment in large rivers.

Accurate road network information is required to study and analyze the relationship between land usage type and land subsidence, and road extraction from remote sensing images is an important data source for updating road networks. This task has been considered a significant semantic segmentation problem, given the many road extraction methods developed for remote sensing images in recent years. Although impressive results have been achieved by classifying each pixel in the remote sensing image using a semantic segmentation network, traditional semantic segmentation methods often lack clear constraints of road features. Consequently, the geometric features of the results might deviate from actual roads, leading to issues like road fractures, rough edges, inconsistent road widths, and more, which hinder their effectiveness in road updates. This paper proposes a novel road semantic segmentation algorithm for remote sensing images based on the joint road angle prediction. By incorporating the angle prediction module and the angle feature fusion module, constraints are added to the angle features of the road. Through the angle prediction and angle feature fusion, the information contained in the remote sensing images can be better utilized. The experimental results show that the proposed method outperforms existing semantic segmentation methods in both quantitative evaluation and visual effects. Furthermore, the extracted roads were consecutive with distinct edges, making them more suitable for mapping road updates.

BackgroundA number of studies have investigated the influencing factors regarding the renewal of contracts associated with Family Doctor Contract Services (FDCS) in different regions of China since it was officially implemented in 2009; however, none of the previous studies have been considered using a nationally representative sample in combination with a meta-analysis.MethodsA multistage stratified sampling method was used to investigate participants’ socio-demographic characteristics, health status, understanding, use, and evaluation of the FDCS, and their willingness to renew contracts in Eastern, Central, and Western China from September to November 2021. We searched the PubMed, Ovid Medline, CNKI, VIP, Wanfang, and SinoMed databases to retrieve previous studies related to the willingness of Chinese residents to renew contracts with their family doctor (FD), and a meta-analysis was performed to systematically summarize the willingness to maintain contracts and influencing factors.ResultsAmong 2,394 residents, 2,122 (88.64%) were willing to renew their contracts. The mixed-effect logistic regression model results demonstrated that residents who (1) preferred primary health service institutions, (2) had a better knowledge of FDCS, (3) were more willing to visit primary health service after signing the contract with FDs, (4) were not intending to change FDs, (5) were satisfied with FDCS, and (6) trusted in FDs reported a higher level of willingness to maintain contracts with FDs. Our meta-analysis confirmed that older age, being married, having chronic diseases, choosing primary medical institutions for the first contact, having a good knowledge of FDCS/FDs, being satisfied with FDCS and the medical skills of FDs, and trusting FDs were all positively associated with residents’ willingness to renew contracts (p

The cornea functions as the primary barrier of the ocular surface, regulating temperature and humidity while providing protection against oxidative stress, harmful stimuli and pathogenic microorganisms. Corneal diseases can affect the biomechanical and optical properties of the eye, resulting in visual impairment or even blindness. Due to their diverse origins and potent biological activities, plant secondary metabolites known as polyphenols offer potential advantages for treating corneal diseases owing to their anti-inflammatory, antioxidant, and antibacterial properties. Various polyphenols and their derivatives have demonstrated diverse mechanisms of action in vitro and in vivo, exhibiting efficacy against a range of corneal diseases including repair of tissue damage, treatment of keratitis, inhibition of neovascularization, alleviation of dry eye syndrome, among others. Therefore, this article presents a concise overview of corneal and related diseases, along with an update on the research progress of natural polyphenols in safeguarding corneal health. A more comprehensive understanding of natural polyphenols provides a novel perspective for secure treatment of corneal diseases.

AbstractBackground & Aims Individuals with high blood pressure (BP) have varying risks of cardiovascular events due to other coexisting factors. We aimed to identify the predictors of long-term absence of coronary artery calcium (CAC) in individuals with high BP, which is an indicator of healthy arterial aging and can guide preventive strategies.Methods We analyzed data from participants with high BP (≥120/80 mm Hg) in the Multi-Ethnic Study of Atherosclerosis who had baseline CAC = 0 and underwent a second CAC scanning after 10 years. We used multivariable logistic regression to evaluate the association between various risk factors for atherosclerotic cardiovascular disease (ASCVD) and long-term CAC = 0. We also calculated the area under the receiver operating characteristic curve (AUC) to predict the phenotype of healthy arterial aging in this population.Results We included 830 participants (37.6% male, mean ± SD age of 59.4 ± 8.7 years). During follow-up, 46.5% of participants (n = 386) had CAC = 0, and they were younger and had fewer metabolic syndrome components. Adding ASCVD risk factors to the demographic model (age, sex, and ethnicity) moderately increased the predictive value for long-term CAC = 0 (AUC: demographic model + ASCVD risk factors vs. demographic model alone, 0.653 vs. 0.597, p

Abstract We previously presented day 29 interim safety and immunogenicity results from a phase 2/3 study (NCT04927065) comparing the Omicron-BA.1-containing bivalent vaccine mRNA-1273.214 (50-µg) to the 50-µg mRNA-1273 booster in adults who previously received the mRNA-1273 primary series (100-µg) and mRNA-1273 first booster (50-µg) dose. Primary endpoints were safety, non-inferiority of the neutralizing antibody (nAb) and seroresponse against Omicron BA.1, superiority of the nAb response against Omicron-BA.1, and non-inferiority of the nAb response against ancestral SARS-CoV-2 for second boosters of mRNA-1273.214 versus mRNA-1273 at days 29 and 91. The key secondary endpoint was the seroresponse difference of mRNA-1273.214 versus mRNA-1273 against ancestral SARS-CoV-2 at days 29 and day 91. Participants were sequentially enrolled and dosed with 50-µg of mRNA-1273 (n = 376) or mRNA-1273.214 (n = 437) as second booster doses. Here we present day 91 post-booster results. In participants with no pre-booster, severe acute respiratory syndrome coronavirus 2-infection (SARS-CoV-2), mRNA-1273.214 elicited Omicron-BA.1-nAb titers (95% confidence interval [CI]) that were significantly higher (964.4 [834.4-1114.7]) than those of mRNA-1273 (624.2 [533.1-730.9]) and similar to those of mRNA-1273 against ancestral SARS-CoV-2 at day 91. mRNA-1273.214 also induced higher binding antibody responses against Omicron BA.1 and alpha, gamma and delta variants than mRNA-1273. Safety profiles were similar for both vaccines. The Omicron-BA.1 bivalent vaccine improved antibody responses compared to mRNA-1273 through 90 days post-booster.

Effective manipulations of thermal expansion and conductivity are significant for improving operational performances of protective coatings, thermoelectric, and radiators. This work uncovers determinant mechanisms of the thermal expansion and conductivity of symbiotic ScTaO4/SmTaO4 composites as thermal/environmental barrier coatings (T/EBCs), and we consider the effects of interface stress and thermal resistance. The weak bonding and interface stress among composite grains manipulate coefficient of thermal expansion (CTE) stretching from 6.4×10−6 to 10.7×10−6 K−1 at 1300 ℃, which gets close to that of substrates in T/EBC systems. The multiscale effects, including phonon scattering at the interface, mitigation of the phonon speed (vp), and lattice point defects, synergistically depress phonon thermal transports, and we estimate the proportions of different parts. The interface thermal resistance (R) reduces the thermal conductivity (k) by depressing phonon speed and scattering phonons because of different acoustic properties and weak bonding between symbiotic ScTaO4 and SmTaO4 ceramics in the composites. This study proves that CTE of tantalates can be artificially regulated to match those of different substrates to expand their applications, and the uncovered multiscale effects can be used to manipulate thermal transports of various materials.

Abstract The ability to deliver electrons is vital for dye-based photocatalysts. Conventionally, the aromatic stacking-based charge-transfer complex increases photogenerated electron accessibility but decreases the energy of excited-state dyes. To circumvent this dilemma, here we show a strategy by tuning the stacking mode of dyes. By decorating naphthalene diimide with S-bearing branches, the S···S contact-linked naphthalene diimide string is created in coordination polymer, thereby enhancing electron mobility while simultaneously preserving competent excited-state reducing power. This benefit, along with in situ assembly between naphthalene diimide strings and exogenous reagent/reactant, improves the accessibility of short-lived excited states during consecutive photon excitation, resulting in greater efficiency in photoinduced electron-transfer activation of inert bonds in comparison to other coordination polymers with different dye-stacking modes. This heterogeneous approach is successfully applied in the photoreduction of inert aryl halides and the successive formation of CAr−C/S/P/B bonds with potential pharmaceutical applications.

Abstract. Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease characterized by progressive lung fibrogenesis and histological features of usual interstitial pneumonia. IPF has a poor prognosis and presents a spectrum of disease courses ranging from slow evolving disease to rapid deterioration; thus, a differential diagnosis remains challenging. Several biomarkers have been identified to achieve a differential diagnosis; however, comprehensive reviews are lacking. This review summarizes over 100 biomarkers which can be divided into six categories according to their functions: differentially expressed biomarkers in the IPF compared to healthy controls; biomarkers distinguishing IPF from other types of interstitial lung disease; biomarkers differentiating acute exacerbation of IPF from stable disease; biomarkers predicting disease progression; biomarkers related to disease severity; and biomarkers related to treatment. Specimen used for the diagnosis of IPF included serum, bronchoalveolar lavage fluid, lung tissue, and sputum. IPF-specific biomarkers are of great clinical value for the differential diagnosis of IPF. Currently, the physiological measurements used to evaluate the occurrence of acute exacerbation, disease progression, and disease severity have limitations. Combining physiological measurements with biomarkers may increase the accuracy and sensitivity of diagnosis and disease evaluation of IPF. Most biomarkers described in this review are not routinely used in clinical practice. Future large-scale multicenter studies are required to design and validate suitable biomarker panels that have diagnostic utility for IPF.

In this study, different concentrations of 17-β estradiol silk fibroin (SF)porous scaffolds (SFPS) were prepared using freeze-drying technique, with a hope for optimal concentration and apply it locally to the bone defect area. In this study, the porous scaffold morphology structure was characterized by SEM, FTIR and universal capacity testing machines, and the in vitro cytocompatibility and biological activity of scaffold materials were studied by cell adhesion, viability and proliferation experiments. The results showed that SFPS boasts better physicochemical properties, while 17-β estradiol SF scaffolds with low concentrations of 10−10 mol/L and 10−12 mol/L had more growth and proliferation of SF scaffolds with higher concentrations, and 10−10 mol/L was the optimal concentration of 17-β estradiol SFPS, which was more conducive to cell adhesion and proliferation. On the other hand, after osteogenesis induction of BMSCs inoculated on 17-β estradiol SFPS at different concentrations, it was found that the expression of alkaline phosphatase in BMSCs on different concentrations of 17-β estradiol porous scaffolds was not large. No conflict of interest exits in the submission of this manuscript.

Altered cell-cell communication is a hallmark of aging, but its impact on bone marrow aging remains poorly understood. Based on a common and effective pipeline and single-cell transcriptome sequencing, we detected 384,124 interactions including 2575 ligand-receptor pairs and 16 non-adherent bone marrow cell types in old and young mouse and identified a total of 5560 significantly different interactions, which were then verified by flow cytometry and quantitative real-time PCR. These differential ligand-receptor interactions exhibited enrichment for the senescence-associated secretory phenotypes. Further validation demonstrated supplementing specific extracellular ligands could modify the senescent signs of hematopoietic stem cells derived from old mouse. Our work provides an effective procedure to detect the ligand-receptor interactions based on single-cell sequencing, which contributes to understand mechanisms and provides a potential strategy for intervention of bone marrow aging.

Chickens are sensitive to heat stress because their capacity to dissipate body heat is low. Hence, in chickens, excessive ambient temperature negatively influences their reproductive performance and health. Heat stress induces inflammation and oxidative stress, thereby rendering many reproductive organs dysfunctional. In this study, we evaluated the effects of the supplementation of dietary quercetin and vitamin E on the uterine function, eggshell quality via estrogen concentration, calcium metabolism, and antioxidant status of the uterus of laying hens under heat stress. The ambient temperature transformation was set at 34 ± 2 °C for 8 h/d (9:00 am–5:00 pm), which was followed by 22 °C to 28 °C for 16 h/d. Throughout the experiment, the relative humidity in the chicken’s pen was at 50 to 65%. A total of 400 Tianfu breeder hens (120-days-old) were randomly divided into four dietary experimental groups, including basal diet (Control); basal diet + 0.4 g/kg quercetin; basal diet + 0.2 g/kg vitamin E; and basal diet + the combination of quercetin (0.4 g/kg) and vitamin E (0.2 g/kg). The results show that the combination of quercetin and vitamin E significantly increased the serum alkaline phosphatase levels and the antioxidant status of the uterus (p < 0.05). In addition, the combination of quercetin and vitamin E significantly increased the concentrations of serum estrogen and progesterone, as well as elevated the expression of hypothalamic gonadotropin-releasing hormone-1 and follicular cytochrome P450 family 19 subfamily A member-1 (p < 0.05). We also found that the calcium levels of the serum and uterus were significantly increased by the synergistic effects of quercetin and vitamin E (p < 0.05), and they also increased the expression of Ca2+-ATPase and the mRNA expression of calcium-binding-related genes in the uterus (p < 0.05). These results are consistent with the increased eggshell quality of the laying hens under heat stress. Further, the combination of quercetin and vitamin E significantly increased the uterine morphological characteristics, such as the height of the uterine mucosal fold and the length of the uterine mucosa villus of the heat-stressed laying hens. These results collectively improve the uterine function, serum and uterine calcium concentration, eggshell strength, and eggshell thickness (p < 0.05) in heat-stressed laying hens. Taken together, we demonstrated in the present study that supplementing the combination of dietary quercetin and vitamin E alleviated the effects of heat stress and improved calcium metabolism, hormone synthesis, and uterine function in the heat-stressed laying hens. Thus, the supplementation of the combination of quercetin and vitamin E alleviates oxidative stress in the eggshell gland of heat-stressed laying hens, thereby promoting calcium concentration in the serum and eggshell gland, etc., in laying hens. Hence, the combination of quercetin and vitamin E promotes the reproductive performance of the laying hens under heat stress and can also be used as a potent anti-stressor in laying hens.

Promoting safe behaviors among construction workers and mitigating unsafe behaviors is an effective approach to enhancing safety performance in the construction industry. Although progress has been made, the research themes concerning construction workers’ safety-related behaviors (CWSRB) and the detailed progress of each theme remain unclear due to differences in review perspectives and conceptual scopes. This study utilized CiteSpace software (V6.2R3 version) to conduct an analysis of co-authorship networks, co-word networks, and co-citations on 563 published articles in this field from 2013 to 2023. This study’s outcomes highlight several key insights: (1) journals such as Safety Science play a pivotal role in the domain; (2) institutions such as the City University of Hong Kong and Hong Kong Polytechnic University, along with prolific authors like Li, are major contributors to the field; (3) the focus of research has evolved from early organizational factors towards a more diverse range of topics, with deep learning emerging as a significant current research hotspot; (4) this study has identified high-cited literature and 11 primary clusters within the field. Current research focuses on five areas: safety-related behavior concepts, influencing factors and consequences, formation mechanisms, interventions, and applications of new technologies. Establishing clear classification criteria for unsafe behaviors, comprehensively understanding the formation mechanisms of safety-related behaviors, evaluating the effectiveness of intervention strategies, and exploring the practical applications of new technologies are future research directions. This study provides researchers with a holistic view of the present state of research and potential avenues for future exploration, thereby deepening the knowledge and comprehension of stakeholders within this domain.

Zanthoxylum nitidum (Roxb.) DC. (Z. nitidum) is a traditional Chinese medicinal plant that is indigenous to the southern regions of China. Previous research has provided evidence of the significant anti-inflammatory, antibacterial, and anticancer properties exhibited by Z. nitidum. The potential therapeutic effects and cardiac toxicity of Z. nitidum remain uncertain. The aim of this research was to investigate the potential therapeutic properties of the four main compounds of Z. nitidum in cardiovascular diseases, their impact on the electrical activity of cardiomyocytes, and the underlying mechanism of their anti-inflammatory effects. We selected the four compounds from Z. nitidum with a high concentration and specific biological activity: nitidine chloride (NC), chelerythrine chloride (CHE), magnoflorine chloride (MAG), and hesperidin (HE). A proteomic analysis was conducted on the myocardial tissues of beagle dogs following the administration of NC to investigate the role of NC in vivo and the associated biological processes. A bioinformatic analysis was used to predict the in vivo biological processes that MAG, CHE, and HE were involved in. Molecular docking was used to simulate the binding between compounds and their targets. The effect of the compounds on ion channels in cardiomyocytes was evaluated through a patch clamp experiment. Organ-on-a-chip (OOC) technology was developed to mimic the physiological conditions of the heart in vivo. Proteomic and bioinformatic analyses demonstrated that the four compounds of Z. nitidum are extensively involved in various cardiovascular-related biological pathways. The findings from the patch clamp experiments indicate that NC, CHE, MAG, and HE elicit a distinct activation or inhibition of the IK1 and ICa-L in cardiomyocytes. Finally, the anti-inflammatory effects of the compounds on cardiomyocytes were verified using OOC technology. NC, CHE, MAG, and HE demonstrate anti-inflammatory effects through their specific interactions with prostaglandin-endoperoxide synthase 2 (PTGS2) and significantly influence ion channels in cardiomyocytes. Our study provides a foundation for utilizing NC, CHE, MAG, and HE in the treatment of cardiovascular diseases.

Background: Both genetics and vitamin D deficiency are associated with childhood obesity. However, the role of vitamin D status between polygenic and childhood obesity has been unknown. The current study aimed to determine the relation between genetic factors, vitamin D status, and BMI-for-age z score (zBMI) in Chinese preschool children. Methods: A total of 1046 participants aged 3.7 to 6.6 years old from the Long-term Health Effects Assessment Project of Infants and Toddlers Nutritional Pack (LHEAPITNP) were included in this study. The polygenic risk score (PRS) was established based on 55 BMI-related single nucleotide polymorphisms (SNPs) derived from a published genome-wide association study (GWAS) for BMI. Serum 25(OH)D was used as an index of vitamin D status and measured with liquid chromatography-tandem mass spectrometry (LC/MS-MS) assay. The Wilcoxon test or Kruskal–Wallis test was used to compare the differences of variables between different groups and Spearman correlation analysis was used for analyzing the correlations between the PRS, 25(OH)D levels, and zBMI. Results: The PRS showed a positive relation to zBMI (rs = 0.0953, p = 0.0022) and 25(OH)D showed a negative relation to zBMI (rs = −0.1082, p = 0.0005) in the full-adjustment model. In addition, the differences in zBMI at different vitamin D statuses in the low-risk PRS group and the intermediate-risk PRS group were both statistically significant (plow = 0.0308, pintermediate = 0.0121), the median zBMI was both higher at vitamin D insufficiency status. And the difference in zBMI between different genetic risk groups was also statistically significant at vitamin D sufficiency status (p = 0.0077). Furthermore, genetic risk showed a positive relation to zBMI at vitamin D sufficiency status, and the p for trend was 0.0028. Conclusions: Our findings suggested that vitamin D was related to zBMI negatively in Chinese preschoolers and maintaining adequate vitamin D levels may only contribute to lower the zBMI in preschoolers with low and intermediate genetic susceptibility.

Intimate partner violence (IPV) is the most common type of domestic violence, which not only harms the victim's physical and mental health and life safety but also leads to the degradation of marriage, family, and children's development. IPV occurs among all socioeconomic, religious, and cultural groups. About a quarter of Chinese women have suffered some forms of IPV from their partner. Most patients will not present to the clinic with IPV. It is difficult yet essential for clinicians to quickly identify possible IPV among various non-specific symptoms and signs. There are no official guidelines for diagnosing and treating IPV in China, and the Chinese literature on IPV is scarce. This paper summarizes the evidence in English literature on IPV, focusing on the clinical outcome, identification, and management techniques of IPV, and attempts to discuss how this evidence can be applied to China.

Recent advances in inverse-design approaches for discovering optical structures based on desired functional characteristics have reshaped the landscape of nanophotonic structures, where most studies have focused on how light interacts with nanophotonic structures only. When quantum emitters (QEs), such as atoms, molecules, and quantum dots, are introduced to couple to the nanophotonic structures, the light–matter interactions become much more complicated, forming a rapidly developing field – quantum nanophotonics. Typical quantum functional characteristics depend on the intrinsic properties of the QE and its electromagnetic environment created by the nanophotonic structures, commonly represented by a scalar quantity, local-density-of-states (LDOS). In this work, we introduce a generalized inverse-design framework in quantum nanophotonics by taking LDOS as the bridge to connect the nanophotonic structures and the quantum functional characteristics. We take a simple system consisting of QEs sitting on a single multilayer shell–metal–nanoparticle (SMNP) as an example, apply fully-connected neural networks to model the LDOS of SMNP, inversely design and optimize the geometry of the SMNP based on LDOS, and realize desirable quantum characteristics in two quantum nanophotonic problems: spontaneous emission and entanglement. Our work introduces deep learning to the quantum optics domain for advancing quantum device designs; and provides a new platform for practicing deep learning to design nanophotonic structures for complex problems without a direct link between structures and functional characteristics.

Abstract Background Roughly 50% of adult gliomas harbor isocitrate dehydrogenase (IDH) mutations. According to the 2021 WHO classification guideline, these gliomas are diagnosed as astrocytomas, harboring no 1p19q co-deletion, or oligodendrogliomas, harboring 1p19q co-deletion. Recent studies report that IDH-mutant gliomas share a common developmental hierarchy. However, the neural lineages and differentiation stages in IDH-mutant gliomas remain inadequately characterized. Methods Using bulk transcriptomes and single-cell transcriptomes, we identified genes enriched in IDH-mutant gliomas with or without 1p19q co-deletion, we also assessed the expression pattern of stage-specific signatures and key regulators of oligodendrocyte lineage differentiation. We compared the expression of oligodendrocyte lineage stage-specific markers between quiescent and proliferating malignant single cells. The gene expression profiles were validated using RNAscope analysis and myelin staining and were further substantiated using data of DNA methylation and single-cell ATAC-seq. As a control, we assessed the expression pattern of astrocyte lineage markers. Results Genes concordantly enriched in both subtypes of IDH-mutant gliomas are upregulated in oligodendrocyte progenitor cells (OPC). Signatures of early stages of oligodendrocyte lineage and key regulators of OPC specification and maintenance are enriched in all IDH-mutant gliomas. In contrast, signature of myelin-forming oligodendrocytes, myelination regulators, and myelin components are significantly down-regulated or absent in IDH-mutant gliomas. Further, single-cell transcriptomes of IDH-mutant gliomas are similar to OPC and differentiation-committed oligodendrocyte progenitors, but not to myelinating oligodendrocyte. Most IDH-mutant glioma cells are quiescent; quiescent cells and proliferating cells resemble the same differentiation stage of oligodendrocyte lineage. Mirroring the gene expression profiles along the oligodendrocyte lineage, analyses of DNA methylation and single-cell ATAC-seq data demonstrate that genes of myelination regulators and myelin components are hypermethylated and show inaccessible chromatin status, whereas regulators of OPC specification and maintenance are hypomethylated and show open chromatin status. Markers of astrocyte precursors are not enriched in IDH-mutant gliomas. Conclusions Our studies show that despite differences in clinical manifestation and genomic alterations, all IDH-mutant gliomas resemble early stages of oligodendrocyte lineage and are stalled in oligodendrocyte differentiation due to blocked myelination program. These findings provide a framework to accommodate biological features and therapy development for IDH-mutant gliomas.

There is no targeted therapy for KRAS proto‐oncogene, GTPase (KRAS)‐mutant metastatic colorectal cancer (mCRC) because the underlying mechanism remains obscure. Based on bioinformatic analysis, this study aims to elucidate a potential gene target for which an approved drug is available, and to reveal the function as well as the underlying mechanism of the candidate gene. Here, we identified that ryanodine receptor 2 (RyR2) expression was upregulated in KRAS‐mutant mCRC, and that this promoted cancer cell metastasis. S107, an approved drug to inhibit calcium release from RyR2 in the clinic, inhibited cancer cell metastasis both in vitro and in vivo. High expression of RyR2 predicts poor survival in our patient cohort. CRC patients with serosa invasion and vascular tumor thrombus are characterized by high RyR2 expression. Analysis of expression profiles upon RyR2 knockdown and inhibition, revealed a set of metastasis‐related molecules, and identified BTB domain and CNC homolog 1 (BACH1) as the main transcription factor regulated by RyR2. RyR2 regulates cellular reactive oxygen species (ROS) levels, which activates nuclear factor erythroid 2‐related factor 2 (Nrf2; also known as NFE2L2) and HMOX1 expression, and thus BACH1 accumulation. Collectively, this study provides evidence that the RyR2/ROS/BACH1 axis may be a potential intervention target for CRC metastasis.

Nowadays potential preclinical drugs for the treatment of nonalcoholic steatohepatitis (NASH) have failed to achieve expected therapeutic efficacy because the pathogenic mechanisms are underestimated. Inactive rhomboid protein 2 (IRHOM2), a promising target for treatment of inflammation-related diseases, contributes to deregulated hepatocyte metabolism-associated nonalcoholic steatohepatitis (NASH) progression. However, the molecular mechanism underlying Irhom2 regulation is still not completely understood. In this work, we identify the ubiquitin-specific protease 13 (USP13) as a critical and novel endogenous blocker of IRHOM2, and we also indicate that USP13 is an IRHOM2-interacting protein that catalyzes deubiquitination of Irhom2 in hepatocytes. Hepatocyte-specific loss of the Usp13 disrupts liver metabolic homeostasis, followed by glycometabolic disorder, lipid deposition, increased inflammation, and markedly promotes NASH development. Conversely, transgenic mice with Usp13 overexpression, lentivirus (LV)- or adeno-associated virus (AAV)-driven Usp13 gene therapeutics mitigates NASH in 3 models of rodent. Mechanistically, in response to metabolic stresses, USP13 directly interacts with IRHOM2 and removes its K63-linked ubiquitination induced by ubiquitin-conjugating enzyme E2N (UBC13), a ubiquitin E2 conjugating enzyme, and thus prevents its activation of downstream cascade pathway. USP13 is a potential treatment target for NASH therapy by targeting the Irhom2 signaling pathway.

Based on the implementing grain security projects and instituting other relevant grain security policies, China has promoted the process of digitalization and intelligence of grain storage and built the world's largest grain Internet of Things, since the 18th National Congress of the Communist Party of China. But, the resulting large amount of grain data, mainly based on temperature, can not effectively support decision-making and management on grain storage. Based on the study of the multi-field coupling theory of grain pile ecosystem, our research team further extracted the continuity principle, periodicity principle, and coordination principle of digital supervision of grain reserves, and proposed a series of intelligent strategies such as AID, ABC, 6R, SIN, CAE, O, and U. However, the application of these strategies directly faces the original data, which has some problems such as low efficiency and large error. To apply the intelligent strategies efficiently and correctly, the basic data manual of intelligent analysis of grain condition has been developed, according to the original grain condition data of typical granaries and main grain varieties in different grain storage ecological regions in China. The development of this manual is expected to consolidate the foundation of intelligent analysis of grain situation, which could promote the digital monitoring of grain storage quantity and quality, and realize the transformation from "manual defense" to “technical defense”.

The grain storage process could be affected by many aspects such as biological field and non biological field, which will lead to the phenomenon of heating, mildew, dewing and pest damage in the grain storage process. It is urgent to develop convenient, fast, multi-functional and high-precision on-site detection tools. According to the requirements of actual grain storage management, the multi-functional grain storage safety on-site rapid detection analyzer could calculate the stored grain moisture, water activity, absolute humidity, accumulated temperature, accumulated humidity, J/Q value and absolute water potential with models and algorithms on the basis of multi-point high-precision detection of temperature, humidity and CO2 concentration, and could graphically expresse the calculated results to assist in the determination of stored grain conditions such as safety, condensation, heat, mildew, etc, which will have mechanical ventilation operation parameter selection and intelligent control. The preliminary application of the instrument shows that it can provide effective technical support for granary management and has a good application prospect.

To explore the structure of longan polysaccharide and its effect on macrophages, a homogenous polysaccharide (named LP) was isolated and purified from longan pulp by ethanol fractional precipitation, and the structure of LP was characterized by gel permeation chromatography with laser light scattering (GPC-LLS), infrared spectroscopy (IR) and nuclear magnetic resonance (NMR) spectroscopy. Meanwhile, its effect on the phagocytic capacity of macrophages and the secretion of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6. The results showed that LP was a heteropolysaccharide with a weight average molecular mass of 8.42 × 105 Da composed of glucose, galactose, mannose, mannuronic acid, arabinose and rhamnose at a molar ratio of 98.70% : 0.57% : 0.35% : 0.09% : 0.20% : 0.12%. NMR spectroscopic analysis showed the backbone chain structure of LP to be 6)-α-Glcp-(1→6)-α-Glcp-(14)-α-Glcp-(-1. LP at 50, 100, 200 μg/mL promoted the phagocytic capacity of macrophages and increased the secretion of TNF-α, IL-1β and IL-6. The phagocytic capacity of LP-induced macrophages increased by 95.61% compared with the untreated control group. TNF-α, IL-1β and IL-6 secretion in macrophages challenged by LP at 50, 100 and 200 μg/mL were 2.38, 10.51 and 10.67 times higher than those in the control group, respectively. These results showed that LP had an activating effect on macrophages, which can provide a scientific basis for the deep processing of longan fruit.

Here, the authors design NaNbO3 based ceramics with the aim of enabling a field-induced reversible phase transformation between the antiferroelectric and ferroelectric phases, which manifests itself in a well-defined double hysteresis loop in the P-E hysteresis curve.