18,439 results on '"Johnson Michael"'
Search Results
152. Title Page, Copyright Page
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Johnson, Michael K.
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- 2023
153. 1. Race, Time Travel, and the Western
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Johnson, Michael K.
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- 2023
154. 3. Alternate Cartographies of the West(ern) in Indigenous Futurist Works
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Johnson, Michael K.
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- 2023
155. 2. Trauma, Time Travel, and Legacies of Violence
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Johnson, Michael K.
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- 2023
156. 4. Speculative Borderlands I: Mestizaje, Temporality, and History
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Johnson, Michael K.
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- 2023
157. Notes
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Johnson, Michael K.
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- 2023
158. Afterword
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Johnson, Michael K.
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- 2023
159. 6. Speculative Slave Narrative Westerns
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Johnson, Michael K.
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- 2023
160. Portfolio of Choice: School Choice in Rural Communities. Brief
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National Comprehensive Center (NCC), Westat, Inc., Robson, Kelly, Johnson, Michael, and O'Neal Schiess, Jennifer
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The goal of this brief is to examine the extent to which different school choice policies have been implemented in rural communities, identify the barriers, and provide recommendations for policymakers looking to expand access to school choice in rural communities. The school choice policies discussed in this brief include: (1) Charter schools; (2) Private school choice programs; (3) Open enrollment; (4) Dual enrollment; (5) Homeschooling; and (6) Virtual schooling. The final section of this brief offers a discussion of the main barriers facing policymakers and education officials in implementing school choice policies in rural communities and recommendations for addressing them. Key takeaways are: (1) Rural schools educate nearly 20 percent of all public, preK-12 students nationwide; (2) Only 32 percent of rural families have access to school choice, compared to 41 percent of families overall, and 53 percent of urban families; (3) Transportation, enrollment and funding, and teacher recruitment and retention are challenges that underlie nearly all types of school choice; and (4) Policymakers can support equitable access to school choice in rural communities by addressing underlying challenges, as well as incentivizing collaboration across school types and collecting data to understand trends in school choice by geography. This publication is one of seven in a series of briefs on school choice from the National Comprehensive Center.
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- 2020
161. Existence and uniqueness of s-curve segments of tensioned elastica satisfying geometric Hermite interpolation conditions
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Johnson, Michael J.
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- 2024
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162. Cooking with liquefied petroleum gas or biomass and fetal growth outcomes: a multi-country randomised controlled trial
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Bankundiye, Gloriose, Boyd Barr, Dana, Burrowes, Vanessa, Bussalleu, Alejandra, Campbell, Devan, Canuz, Eduardo, Castañaza, Adly, Clark, Maggie, Crocker, Mary, De León, Oscar, Dusabimana, Ephrem, Elon, Lisa, Espinoza, Juan G, Pineda Fuentes, Irma, Ghosh, Ahana, Goodman, Dina, Gupton, Savannah, Hamid, Sarah, Harvey, Steven, Hengstermann, Mayari, Hennessee, Ian, Herrera, Phabiola, Howard, Marjorie, Howards, Penelope P., Jaacks, Lindsay, Kearns, Katherine, Kremer, Jacob, Laws, Margaret A., Lenzen, Pattie, Liao, Jiawen, Lovvorn, Amy, Mbabazi, Jane, McPeek, Julia N., Meyers, Rachel, Miranda, J. Jaime, Mollinedo, Erick, Monroy, Libny, Mukhopadhyay, Krishnendu, Mutariyani, Bernard, Naeher, Luke P., Nambajimana, Abidan, Natesan, Durairaj, Nizam, Azhar, Ntivuguruzwa, Jean de Dieu, Piedrahita, Ricardo, Puttaswamy, Naveen, Puzzolo, Elisa, Quinn, Ashlinn, Rajamani, Karthikeyan D., Rajkumar, Sarah, Ramasami, Rengaraj, Ramirez, Alexander, Ryan, P. Barry, Saidam, Sudhakar, Sakas, Zoe, Sambandam, Sankar, Sarnat, Jeremy, Smith, Kirk, Swearing, Damien, Toenjes, Ashley, Underhill, Lindsay, Uwizeyimana, Jean D, Valdes, Viviane, Verma, Amit, Warnock, Megan, Ye, Wenlu, Young, Bonnie, Younger, Ashley, Monroy-Alarcón, Libny Y., Castañaza Gonzalez de Durante, Adly, López-Ortega, Claudia, Gonzalez, Maria F., Sowrirajan, Lakshminarayanan, Paramanandam, Shanthi P., Shanmugavadivu, K, Sudharsanan, V, Seshadri, Suresh, Yupanqui-Fredes, Adhemir E., Hancco-Gomez, Mario, Apaza, Ronald, Persivale-Calle, Juan F., Quispe, Elizabeth, Leon-Ponce, Carlos, Villar-Gonzales, Victor, Andrade-Salas, Rebeca, Herrera, Jhon E., Ramos-Mamani, Luzdelia, Lopez, Yessica, Quiza, Giovanna, Hinojosa, Yadel, Gomez-Quispe, Madeluz, Frisancho-Parada, Gery, Mendoza-Apaza, Danielle I., Quispe-Flores, Luz R., Xavier, Niyitegeka F, Utfimana, Grace, Tuzayisenga, Elie, Nkurunziza, Valens, Checkley, William, Thompson, Lisa M, Hossen, Shakir, Nicolaou, Laura, Williams, Kendra N, Hartinger, Stella M, Chiang, Marilu, Balakrishnan, Kalpana, Garg, Sarada S, Thangavel, Gurusamy, Aravindalochanan, Vigneswari, Rosa, Ghislaine, Mukeshimana, Alexie, Ndagijimana, Florien, McCracken, John P, Diaz-Artiga, Anaité, Sinharoy, Sheela S, Waller, Lance, Wang, Jiantong, Jabbarzadeh, Shirin, Chen, Yunyun, Steenland, Kyle, Kirby, Miles A, Ramakrishnan, Usha, Johnson, Michael, Pillarisetti, Ajay, McCollum, Eric D, Craik, Rachel, Ohuma, Eric O, Dávila-Román, Victor G, de las Fuentes, Lisa, Simkovich, Suzanne M, Peel, Jennifer L, Clasen, Thomas F, and Papageorghiou, Aris T
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- 2024
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163. A window into your status: Environment-based social class’s effect on virtual leadership
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Loignon, Andrew C., Johnson, Michael A., and Veestraeten, Marlies
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- 2024
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164. Evaluation of New Submillimeter VLBI Sites for the Event Horizon Telescope
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Raymond, Alexander W., Palumbo, Daniel, Paine, Scott N., Blackburn, Lindy, Rosado, Rodrigo Córdova, Doeleman, Sheperd S., Farah, Joseph R., Johnson, Michael D., Roelofs, Freek, Tilanus, Remo P. J., and Weintroub, Jonathan
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Event Horizon Telescope (EHT) is a very long baseline interferometer built to image supermassive black holes on event-horizon scales. In this paper, we investigate candidate sites for an expanded EHT array with improved imaging capabilities. We use historical meteorology and radiative transfer analysis to evaluate site performance. Most of the existing sites in the EHT array have median zenith opacity less than 0.2 at 230 GHz during the March/April observing season. Seven of the existing EHT sites have 345 GHz opacity less than 0.5 during observing months. Out of more than forty candidate new locations analyzed, approximately half have 230 GHz opacity comparable to the existing EHT sites, and at least seventeen of the candidate sites would be comparably good for 345 GHz observing. A group of new sites with favorable transmittance and geographic placement leads to greatly enhanced imaging and science on horizon scales.
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- 2021
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165. The more legs the merrier: A new composition for symmetric (multi-)lenses
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Johnson, Michael and Rosebrugh, Robert
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Mathematics - Category Theory - Abstract
Lenses are a category theoretic construct and are used in a wide variety of applications. Symmetric lenses compose to, of course, form new symmetric lenses. Symmetric lenses are usually represented as spans of asymmetric lenses. In many applications, the fact that a symmetric lens might also be represented as a cospan of asymmetric lenses is important, especially for implementation purposes. However, the composition of symmetric lenses does not preserve the property that the lenses can be represented by cospans -- two such symmetric lenses may (and frequently do) compose to form a symmetric lens which cannot be represented as a cospan of asymmetric lenses. Thus preserving the factorisation to show how cospans of asymmetric lenses might be used in implementations becomes important. In 2018, the first work on multilenses was begun. Multilenses can be represented as multi-spans of asymmetric lenses (often called 'wide spans', these are spans with an arbitrary finite number of legs). In this paper we analyse a small but realistic example of a supply chain in which the cospan representations would be 'composed away' by ordinary symmetric lens composition, and introduce a new kind of composition which we call 'fusion' in which two ordinary symmetric lenses (spans with two legs) fuse to form a multilens with three legs preserving the cospan representations, and more generally, two symmetric multilenses, spans with say m and n legs, fuse to form a symmetric multilens with m+n-1 legs, again preserving cospan representations., Comment: In Proceedings ACT 2020, arXiv:2101.07888
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- 2021
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166. Spinal fractures in fused spines: nonoperative treatment is a reliable alternative
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Bäcker, Henrik C., Elias, Patrick, Hanlon, Jack, Cunningham, John, Johnson, Michael A., and Turner, Peter
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- 2023
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167. Forecasting ward-level bed requirements to aid pandemic resource planning: Lessons learned and future directions
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Johnson, Michael R., Naik, Hiten, Chan, Wei Siang, Greiner, Jesse, Michaleski, Matt, Liu, Dong, Silvestre, Bruno, and McCarthy, Ian P.
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- 2023
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168. HAI-1 is required for the novel role of FGFBP1 in maintenance of cell morphology and F-actin rearrangement in human keratinocytes
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Lu, Dajun D., Huang, Nanxi, Li, Sheng-Wen A., Fang, Jessica R., Lai, Chih-Hsin, Wang, Jehng-Kang, Chan, Khee-Siang, Johnson, Michael D., and Lin, Chen-Yong
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- 2023
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169. Writing and Reading Differently : Deconstruction and the Teaching of Composition and Literature
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ATKINS, G. DOUGLAS, JOHNSON, MICHAEL L., ATKINS, G. DOUGLAS, and JOHNSON, MICHAEL L.
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- 2024
170. Light echos and coherent autocorrelations in a black hole spacetime
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Chesler, Paul M., Blackburn, Lindy, Doeleman, Sheperd S., Johnson, Michael D., Moran, James M., Narayan, Ramesh, and Wielgus, Maciek
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General Relativity and Quantum Cosmology ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The Event Horizon Telescope recently produced the first images of a black hole. These images were synthesized by measuring the coherent correlation function of the complex electric field measured at telescopes located across the Earth. This correlation function corresponds to the Fourier transform of the image under the assumption that the source emits spatially incoherent radiation. However, black holes differ from standard astrophysical objects: in the absence of absorption and scattering, an observer sees a series of increasingly demagnified echos of each emitting location. These echos correspond to rays that orbit the black hole one or more times before reaching the observer. This multi-path propagation introduces spatial and temporal correlations into the electric field that encode properties of the black hole, irrespective of intrinsic variability. We explore the coherent temporal autocorrelation function measured at a single telescope. Specifically, we study the simplified toy problem of scalar field correlation functions $\langle \Psi(t) \Psi(0) \rangle$ sourced by fluctuating matter located near a Schwarzschild black hole. We find that the correlation function is peaked at times equal to integer multiples of the photon orbit period; the corresponding power spectral density vanishes like $\lambda/r_{\rm g}$ where $r_{\rm g} = G M / c^{2}$ is the gravitational radius of the black hole and $\lambda$ is the wavelength of radiation observed. For supermassive black holes observed at millimeter wavelengths, the power in echos is suppressed relative to direct emission by $\sim 10^{-13} \lambda_{\rm mm}/M_{6}$, where $\lambda_{\rm mm} = \lambda/(1\,{\rm mm})$ and $M_6 = M/(10^6 M_\odot)$. Consequently, detecting multi-path propagation near a black hole using the coherent electric field autocorrelation is infeasible with current technology., Comment: 15 pages, 5 figures
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- 2020
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171. Photon Ring Autocorrelations
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Hadar, Shahar, Johnson, Michael D., Lupsasca, Alexandru, and Wong, George N.
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General Relativity and Quantum Cosmology ,Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Theory - Abstract
In the presence of a black hole, light sources connect to observers along multiple paths. As a result, observed brightness fluctuations must be correlated across different times and positions in black hole images. Photons that execute multiple orbits around the black hole appear near a critical curve in the observer sky, giving rise to the photon ring. In this paper, a novel observable is proposed: the two-point correlation function of intensity fluctuations on the photon ring. This correlation function is analytically computed for a Kerr black hole surrounded by stochastic equatorial emission, with source statistics motivated by simulations of a turbulent accretion flow. It is shown that this two-point function exhibits a universal, self-similar structure consisting of multiple peaks of identical shape: while the profile of each peak encodes statistical properties of fluctuations in the source, the locations and heights of the peaks are determined purely by the black hole parameters. Measuring these peaks would demonstrate the existence of the photon ring without resolving its thickness, and would provide estimates of black hole mass and spin. With regular monitoring over sufficiently long timescales, this measurement could be possible via interferometric imaging with modest improvements to the Event Horizon Telescope., Comment: 31 pages, 3 figures. v2: published version. v3: minor corrections, summarized in an appendix; conclusions essentially unchanged
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- 2020
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172. Gravitational Test Beyond the First Post-Newtonian Order with the Shadow of the M87 Black Hole
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Psaltis, Dimitrios, Medeiros, Lia, Christian, Pierre, Ozel, Feryal, Akiyama, Kazunori, Alberdi, Antxon, Alef, Walter, Asada, Keiichi, Azulay, Rebecca, Ball, David, Balokovic, Mislav, Barrett, John, Bintley, Dan, Blackburn, Lindy, Boland, Wilfred, Bower, Geoffrey C., Bremer, Michael, Brinkerink, Christiaan D., Brissenden, Roger, Britzen, Silke, Broguiere, Dominique, Bronzwaer, Thomas, Byun, Do-Young, Carlstrom, John E., Chael, Andrew, Chan, Chi-kwan, Chatterjee, Shami, Chatterjee, Koushik, Chen, Ming-Tang, Chen, Yongjun, Cho, Ilje, Conway, John E., Cordes, James M., Crew, Geoffrey B., Cui, Yuzhu, Davelaar, Jordy, De Laurentis, Mariafelicia, Deane, Roger, Dempsey, Jessica, Desvignes, Gregory, Dexter, Jason, Eatough, Ralph P., Falcke, Heino, Fish, Vincent L., Fomalont, Ed, Fraga-Encinas, Raquel, Friberg, Per, Fromm, Christian M., Gammie, Charles F., García, Roberto, Gentaz, Olivier, Goddi, Ciriaco, Gomez, Jose L., Gu, Minfeng, Gurwell, Mark, Hada, Kazuhiro, Hesper, Ronald, Ho, Luis C., Ho, Paul, Honma, Mareki, Huang, Chih-Wei L., Huang, Lei, Hughes, David H., Inoue, Makoto, Issaoun, Sara, James, David J., Jannuzi, Buell T., Janssen, Michael, Jiang, Wu, Jimenez-Rosales, Alejandra, Johnson, Michael D., Jorstad, Svetlana, Jung, Taehyun, Karami, Mansour, Karuppusamy, Ramesh, Kawashima, Tomohisa, Keating, Garrett K., Kettenis, Mark, Kim, Jae-Young, Kim, Junhan, Kim, Jongsoo, Kino, Motoki, Koay, Jun Yi, Koch, Patrick M., Koyama, Shoko, Kramer, Michael, Kramer, Carsten, Krichbaum, Thomas P., Kuo, Cheng-Yu, Lauer, Tod R., Lee, Sang-Sung, Li, Yan-Rong, Li, Zhiyuan, Lindqvist, Michael, Lico, Rocco, Liu, Jun, Liu, Kuo, Liuzzo, Elisabetta, Lo, Wen-Ping, Lobanov, Andrei P., Lonsdale, Colin, Lu, Ru-Sen, Mao, Jirong, Markoff, Sera, Marrone, Daniel P., Marscher, Alan P., Martí-Vidal, Ivan, Matsushita, Satoki, Mizuno, Yosuke, Mizuno, Izumi, Moran, James M., Moriyama, Kotaro, Moscibrodzka, Monika, Muller, Cornelia, Musoke, Gibwa, Mejías, Alejandro Mus, Nagai, Hiroshi, Nagar, Neil M., Narayan, Ramesh, Narayanan, Gopal, Natarajan, Iniyan, Neri, Roberto, Noutsos, Aristeidis, Okino, Hiroki, Olivares, Hector, Oyama, Tomoaki, Palumbo, Daniel C. M., Park, Jongho, Patel, Nimesh, Pen, Ue-Li, Pietu, Vincent, Plambeck, Richard, PopStefanija, Aleksandar, Prather, Ben, Preciado-Lopez, Jorge A., Ramakrishnan, Venkatessh, Rao, Ramprasad, Rawlings, Mark G., Raymond, Alexander W., Ripperda, Bart, Roelofs, Freek, Rogers, Alan, Ros, Eduardo, Rose, Mel, Roshanineshat, Arash, Rottmann, Helge, Roy, Alan L., Ruszczyk, Chet, Ryan, Benjamin R., Rygl, Kazi L. J., Sanchez, Salvador, Sanchez-Arguelles, David, Sasada, Mahito, Savolainen, Tuomas, Schloerb, F. Peter, Schuster, Karl-Friedrich, Shao, Lijing, Shen, Zhiqiang, Small, Des, Sohn, Bong Won, SooHoo, Jason, Tazaki, Fumie, Tilanus, Remo P. J., Titus, Michael, Torne, Pablo, Trent, Tyler, Traianou, Efthalia, Trippe, Sascha, van Bemmel, Ilse, van Langevelde, Huib Jan, van Rossum, Daniel R., Wagner, Jan, Wardle, John, Ward-Thompson, Derek, Weintroub, Jonathan, Wex, Norbert, Wharton, Robert, Wielgus, Maciek, Wong, George N., Wu, Qingwen, Yoon, Doosoo, Young, Andre, Young, Ken, Younsi, Ziri, Yuan, Feng, Yuan, Ye-Fei, Zhao, Shan-Shan, and Collaboration, the EHT
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General Relativity and Quantum Cosmology ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The 2017 Event Horizon Telescope (EHT) observations of the central source in M87 have led to the first measurement of the size of a black-hole shadow. This observation offers a new and clean gravitational test of the black-hole metric in the strong-field regime. We show analytically that spacetimes that deviate from the Kerr metric but satisfy weak-field tests can lead to large deviations in the predicted black-hole shadows that are inconsistent with even the current EHT measurements. We use numerical calculations of regular, parametric, non-Kerr metrics to identify the common characteristic among these different parametrizations that control the predicted shadow size. We show that the shadow-size measurements place significant constraints on deviation parameters that control the second post-Newtonian and higher orders of each metric and are, therefore, inaccessible to weak-field tests. The new constraints are complementary to those imposed by observations of gravitational waves from stellar-mass sources., Comment: Physical Review Letters
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- 2020
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173. Monitoring the Morphology of M87* in 2009-2017 with the Event Horizon Telescope
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Wielgus, Maciek, Akiyama, Kazunori, Blackburn, Lindy, Chan, Chi-kwan, Dexter, Jason, Doeleman, Sheperd S., Fish, Vincent L., Issaoun, Sara, Johnson, Michael D., Krichbaum, Thomas P., Lu, Ru-Sen, Pesce, Dominic W., Wong, George N., Bower, Geoffrey C., Broderick, Avery E., Chael, Andrew, Chatterjee, Koushik, Gammie, Charles F., Georgiev, Boris, Hada, Kazuhiro, Loinard, Laurent, Markoff, Sera, Marrone, Daniel P., Plambeck, Richard, Weintroub, Jonathan, Dexter, Matthew, MacMahon, David H. E., Wright, Melvyn, and Collaboration, the Event Horizon Telescope
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The Event Horizon Telescope (EHT) has recently delivered the first resolved images of M87*, the supermassive black hole in the center of the M87 galaxy. These images were produced using 230 GHz observations performed in 2017 April. Additional observations are required to investigate the persistence of the primary image feature - a ring with azimuthal brightness asymmetry - and to quantify the image variability on event horizon scales. To address this need, we analyze M87* data collected with prototype EHT arrays in 2009, 2011, 2012, and 2013. While these observations do not contain enough information to produce images, they are sufficient to constrain simple geometric models. We develop a modeling approach based on the framework utilized for the 2017 EHT data analysis and validate our procedures using synthetic data. Applying the same approach to the observational data sets, we find the M87* morphology in 2009-2017 to be consistent with a persistent asymmetric ring of ~40 uas diameter. The position angle of the peak intensity varies in time. In particular, we find a significant difference between the position angle measured in 2013 and 2017. These variations are in broad agreement with predictions of a subset of general relativistic magnetohydrodynamic simulations. We show that quantifying the variability across multiple observational epochs has the potential to constrain the physical properties of the source, such as the accretion state or the black hole spin.
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- 2020
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174. Decomposing the Internal Faraday Rotation of Black Hole Accretion Flows
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Ricarte, Angelo, Prather, Ben S., Wong, George N., Narayan, Ramesh, Gammie, Charles, and Johnson, Michael
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Faraday rotation has been seen at millimeter wavelengths in several low luminosity active galactic nuclei, including Event Horizon Telescope (EHT) targets M87* and Sgr A*. The observed rotation measure (RM) probes the density, magnetic field, and temperature of material integrated along the line of sight. To better understand how accretion disc conditions are reflected in the RM, we perform polarized radiative transfer calculations using a set of general relativistic magneto-hydrodynamic (GRMHD) simulations appropriate for M87*. We find that in spatially resolved millimetre wavelength images on event horizon scales, the RM can vary by orders of magnitude and even flip sign. The observational consequences of this spatial structure include significant time-variability, sign-flips, and non-$\lambda^2$ evolution of the polarization plane. For some models, we find that internal rotation measure can cause significant bandwidth depolarization even across the relatively narrow fractional bandwidths observed by the EHT. We decompose the linearly polarized emission in these models based on their RM and find that emission in front of the mid-plane can exhibit orders of magnitude less Faraday rotation than emission originating from behind the mid-plane or within the photon ring. We confirm that the spatially unresolved (i.e., image integrated) RM is a poor predictor of the accretion rate, with substantial scatter stemming from time variability and inclination effects. Models can be constrained with repeated observations to characterise time variability and the degree of non-$\lambda^2$ evolution of the polarization plane., Comment: Accepted for publication by MNRAS
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- 2020
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175. A Prospective ISRO-CfA Himalayan Sub-millimeter-wave Observatory Initiative
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Sridharan, T. K., Bialy, Shmuel, Blundell, Raymond, Burkhardt, Andrew, Dame, Thomas, Doeleman, Sheperd, Finkbeiner, Douglas, Goodman, Alyssa, Grimes, Paul, Imara, Nia, Johnson, Michael, Keating, Garrett, Lada, Charles, Gal, Romane Le, Myers, Philip, Narayan, Ramesh, Paine, Scott, Patel, Nimesh, Raymond, Alexander, Tong, Edward, Wilner, David, Zhang, Qizhou, and Zucker, Catherine
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Smithsonian Astrophysical Observatory (SAO), a member of the Center for Astrophysics | Harvard and Smithsonian, is in discussions with the Space Applications Centre (SAC) of the Indian Space Research Organization (ISRO) and its partners in the newly formed Indian Sub-millimetre-wave Astronomy Alliance (ISAA), to collaborate in the construction of a sub-millimeter-wave astronomy observatory in the high altitude deserts of the Himalayas, initially at the 4500 m Indian Astronomical Observatory, Hanle. Two primary science goals are targeted. One is the mapping of the distribution of neutral atomic carbon, and the carbon monoxide (CO) molecule in higher energy states, in large parts of the Milky Way, and in selected external galaxies. Such studies would advance our understanding of molecular hydrogen present in the interstellar medium, but partly missed by existing observations; and characterize Galaxy-wide molecular cloud excitation conditions, through multi-level CO observations. Stars form in interstellar clouds of molecular gas and dust, and these observations would allow research into the formation and destruction processes of such molecular clouds and the life cycle of galaxies. As the second goal, the observatory would add a new location to the global Event Horizon Telescope (EHT) network, which lacks a station in the Himalayan longitudes. This addition would enhance the quality of the images synthesized by the EHT, support observations in higher sub-millimeter wave bands, sharpening its resolving ability, improve its dynamic imaging capability and add weather resilience to observing campaigns. In the broader context, this collaboration can be a starting point for a wider, mutually beneficial scientific exchange between the Indian and US astronomy communities, including a potential future EHT space component., Comment: Internal white paper prepared in support of the initiative, 32 pages, 7 figures
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- 2020
176. On the approximation of the black hole shadow with a simple polar curve
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Farah, Joseph R., Pesce, Dominic W., Johnson, Michael D., and Blackburn, Lindy L.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics ,General Relativity and Quantum Cosmology - Abstract
A black hole embedded within a bright, optically thin emitting region imprints a nearly circular "shadow" on its image, corresponding to the observer's line-of-sight into the black hole. The shadow boundary depends on the black hole's mass and spin, providing an observable signature of both properties via high resolution images. However, standard expressions for the shadow boundary are most naturally parametrized by Boyer-Lindquist radii rather than by image coordinates. We explore simple, approximate parameterizations for the shadow boundary using ellipses and a family of curves known as limacons. We demonstrate that these curves provide excellent and efficient approximations for all black hole spins and inclinations. In particular, we show that the two parameters of the limacon naturally account for the three primary shadow deformations resulting from mass and spin: size, displacement, and asymmetry. These curves are convenient for parametric model fitting directly to interferometric data, they reveal the degeneracies expected when estimating black hole properties from images with practical measurement limitations, and they provide a natural framework for parametric tests of the Kerr metric using black hole images., Comment: 9 pages, 9 figures; accepted for publication in ApJ
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- 2020
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177. Articulatory-WaveNet: Autoregressive Model For Acoustic-to-Articulatory Inversion
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Bozorg, Narjes and Johnson, Michael T.
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Electrical Engineering and Systems Science - Audio and Speech Processing ,Computer Science - Machine Learning ,Computer Science - Sound - Abstract
This paper presents Articulatory-WaveNet, a new approach for acoustic-to-articulator inversion. The proposed system uses the WaveNet speech synthesis architecture, with dilated causal convolutional layers using previous values of the predicted articulatory trajectories conditioned on acoustic features. The system was trained and evaluated on the ElectroMagnetic Articulography corpus of Mandarin Accented English (EMA-MAE),consisting of 39 speakers including both native English speakers and native Mandarin speakers speaking English. Results show significant improvement in both correlation and RMSE between the generated and true articulatory trajectories for the new method, with an average correlation of 0.83, representing a 36% relative improvement over the 0.61 correlation obtained with a baseline Hidden Markov Model (HMM)-Gaussian Mixture Model (GMM) inversion framework. To the best of our knowledge, this paper presents the first application of a point-by-point waveform synthesis approach to the problem of acoustic-to-articulatory inversion and the results show improved performance compared to previous methods for speaker dependent acoustic to articulatory inversion.
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- 2020
178. Development of the cervical myelopathy severity index: a new patient reported outcome measure to quantify impairments and functional limitations
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Malhotra, Armaan K., He, Yingshi, Harrington, Erin M., Jaja, Blessing N.R., Zhu, Mary P., Shakil, Husain, Dea, Nicolas, Weber, Michael H., Attabib, Najmedden, Phan, Philippe, Rampersaud, Yoga Raja, Paquet, Jerome, Jacobs, W. Bradley, Cadotte, David W., Christie, Sean D., Nataraj, Andrew, Bailey, Christopher S., Johnson, Michael, Fisher, Charles, Hall, Hamilton, Manson, Neil, Thomas, Kenneth, Ginsberg, Howard J., Fehlings, Michael G., Witiw, Christopher D., Davis, Aileen M., and Wilson, Jefferson R.
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- 2024
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179. Plasma deposited amorphous silicon passivation layers on InAs surfaces
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Murphy, John P., Cleveland, Erin R., Boris, David R., Johnson, Michael J., Walton, Scott G., and Nolde, Jill A.
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- 2024
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180. Real-world treatment patterns in drug naïve type 2 diabetes population: Initial combination therapy vs. sequential step-therapy
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Majd, Zahra, Chen, Hua, Johnson, Michael L., Birtcher, Kim K., Serna, Omar, and Abughosh, Susan
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- 2024
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181. Determining the streamer velocity in an atmospheric pressure plasma jet from the target substrate current
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Johnson, Michael J., Enloe, Carl, Boris, David R., Petrova, Tzvetelina B., and Walton, Scott G.
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- 2024
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182. Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland
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Datta Kamal, Hyduke Daniel R, Suman Shubhankar, Moon Bo-Hyun, Johnson Michael D, and Fornace Albert J
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Radiation exposure ,Mouse mammary gland ,Gene expression ,Persistent microarray changes. ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Breast tissue is among the most sensitive tissues to the carcinogenic actions of ionizing radiation and epidemiological studies have linked radiation exposure to breast cancer. Currently, molecular understanding of radiation carcinogenesis in mammary gland is hindered due to the scarcity of in vivo long-term follow up data. We undertook this study to delineate radiation-induced persistent alterations in gene expression in mouse mammary glands 2-month after radiation exposure. Methods Six to eight week old female C57BL/6J mice were exposed to 2 Gy of whole body γ radiation and mammary glands were surgically removed 2-month after radiation. RNA was isolated and microarray hybridization performed for gene expression analysis. Ingenuity Pathway Analysis (IPA) was used for biological interpretation of microarray data. Real time quantitative PCR was performed on selected genes to confirm the microarray data. Results Compared to untreated controls, the mRNA levels of a total of 737 genes were significantly (p Conclusions Exposure to a clinically relevant radiation dose led to long-term activation of mammary gland genes involved in proliferative and metabolic pathways, which are known to have roles in carcinogenesis. When considered along with downregulation of a number of tumor suppressor genes, our study has implications for breast cancer initiation and progression after therapeutic radiation exposure.
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- 2012
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183. An institutional perspective on the impact of recent antibiotic exposure on length of stay and hospital costs for patients with gram-negative sepsis
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Micek Scott, Johnson Michael T, Reichley Richard, and Kollef Marin H
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Antibiotics ,Severe sepsis ,Outcomes ,Length of stay ,Hospital costs ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Prior antibiotic exposure has been associated with the emergence of antibiotic resistance in subsequent bacterial infections, whose outcomes are typically worse than similar infections with more antibiotic susceptible infections. The influence of prior antibiotic exposure on hospital length of stay (LOS) and costs in patients with severe sepsis or septic shock attributed to Gram-negative bacteremia has not been previously examined. Methods A retrospective cohort study of hospitalized patients (January 2002-December 2007) was performed at Barnes-Jewish Hospital, a 1200-bed urban teaching hospital. Patients with Gram-negative bacteremia complicated by severe sepsis or septic shock had data abstraction from computerized medical records. We examined a consecutive cohort of 754 subjects (mean age 59.3 ± 16.3 yrs, mean APACHE II 23.7 ± 6.7). Results Escherichia coli (30.8%), Klebsiella pneumoniae (23.2%), and Pseudomonas aeruginosa (17.6%) were the most common organisms isolated from blood cultures. 310 patients (41.1%) had exposure to antimicrobial agents in the previous 90 days. Patients with recent antibiotic exposure had greater inappropriate initial antimicrobial therapy (45.4% v. 21.2%; p < 0.001) and hospital mortality (51.3% v. 34.0%; p < 0.001) compared to patients without recent antibiotic exposure. The unadjusted median LOS (25th percentile, 75th percentile) following sepsis onset in patients with prior antimicrobial exposure was 13.0 days (5.0 days, 24.0 days) compared to 8.0 days (5.0 days, 14.0 days) in those without prior antimicrobial exposure (p < 0.001). In a Cox model controlling for multiple confounders, prior antibiotic exposure independently correlated with remaining hospitalized (Adjusted hazard ratio: 1.473, 95% CI: 1.297-1.672, p < 0.001). Adjusting for potential confounders indicated that prior antibiotic exposure independently increased median attributable LOS by 5.0 days. Similarly, total hospital costs following sepsis onset was significantly greater among patients with prior antimicrobial exposure (median values: $94,737 v. $21,329; p < 0.001). Conclusions Recent antibiotic exposure is associated with increased LOS and hospital costs in Gram-negative bacteremia complicated by severe sepsis or septic shock. Clinicians and hospital administrators should consider the potential impact of recent antibiotic exposure when formulating empiric treatment decisions for patients with serious infections attributed to Gram-negative bacteria.
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- 2012
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184. Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations
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Stevelink, Remi, Luykx, Jurjen J, Lin, Bochao D, Leu, Costin, Lal, Dennis, Smith, Alexander W, Schijven, Dick, Carpay, Johannes A, Rademaker, Koen, Baldez, Roiza A Rodrigues, Devinsky, Orrin, Braun, Kees PJ, Jansen, Floor E, Smit, Dirk JA, Koeleman, Bobby PC, Abou‐Khalil, Bassel, Auce, Pauls, Avbersek, Andreja, Bahlo, Melanie, Balding, David J, Bast, Thomas, Baum, Larry, Becker, Albert J, Becker, Felicitas, Berghuis, Bianca, Berkovic, Samuel F, Boysen, Katja E, Bradfield, Jonathan P, Brody, Lawrence C, Buono, Russell J, Campbell, Ellen, Cascino, Gregory D, Catarino, Claudia B, Cavalleri, Gianpiero L, Cherny, Stacey S, Chinthapalli, Krishna, Coffey, Alison J, Compston, Alastair, Coppola, Antonietta, Cossette, Patrick, Craig, John J, de Haan, Gerrit‐Jan, De Jonghe, Peter, de Kovel, Carolien GF, Delanty, Norman, Depondt, Chantal, Dlugos, Dennis J, Doherty, Colin P, Elger, Christian E, Eriksson, Johan G, Ferraro, Thomas N, Feucht, Martha, Francis, Ben, Franke, Andre, French, Jacqueline A, Freytag, Saskia, Gaus, Verena, Geller, Eric B, Gieger, Christian, Glauser, Tracy, Glynn, Simon, Goldstein, David B, Gui, Hongsheng, Guo, Youling, Haas, Kevin F, Hakonarson, Hakon, Hallmann, Kerstin, Haut, Sheryl, Heinzen, Erin L, Helbig, Ingo, Hengsbach, Christian, Hjalgrim, Helle, Iacomino, Michele, Ingason, Andrés, Jamnadas‐Khoda, Jennifer, Johnson, Michael R, Kälviäinen, Reetta, Kantanen, Anne‐Mari, Kasperavičiūte, Dalia, Trenite, Dorothee Kasteleijn‐Nolst, Kirsch, Heidi E, Knowlton, Robert C, Krause, Roland, Krenn, Martin, Kunz, Wolfram S, Kuzniecky, Ruben, Kwan, Patrick, Lau, Yu‐Lung, Lehesjoki, Anna‐Elina, Lerche, Holger, Lieb, Wolfgang, Lindhout, Dick, Lo, Warren D, Lopes‐Cendes, Iscia, Lowenstein, Daniel H, Malovini, Alberto, Marson, Anthony G, Mayer, Thomas, McCormack, Mark, and Mills, James L
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Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Genetics ,Brain Disorders ,Clinical Research ,Human Genome ,Neurodegenerative ,Epilepsy ,2.1 Biological and endogenous factors ,Aetiology ,Neurological ,Adult ,Algorithms ,Beta Rhythm ,Cohort Studies ,Databases ,Factual ,Electroencephalography ,Epilepsy ,Generalized ,Genome-Wide Association Study ,Humans ,Linkage Disequilibrium ,Mendelian Randomization Analysis ,Risk Assessment ,Theta Rhythm ,beta power ,EEG ,generalized epilepsy ,GGE ,oscillations ,PRS ,International League Against Epilepsy Consortium on Complex Epilepsies ,Epi25 Collaborative ,Neurology & Neurosurgery ,Clinical sciences - Abstract
ObjectiveParoxysmal epileptiform abnormalities on electroencephalography (EEG) are the hallmark of epilepsies, but it is uncertain to what extent epilepsy and background EEG oscillations share neurobiological underpinnings. Here, we aimed to assess the genetic correlation between epilepsy and background EEG oscillations.MethodsConfounding factors, including the heterogeneous etiology of epilepsies and medication effects, hamper studies on background brain activity in people with epilepsy. To overcome this limitation, we compared genetic data from a genome-wide association study (GWAS) on epilepsy (n = 12 803 people with epilepsy and 24 218 controls) with that from a GWAS on background EEG (n = 8425 subjects without epilepsy), in which background EEG oscillation power was quantified in four different frequency bands: alpha, beta, delta, and theta. We replicated our findings in an independent epilepsy replication dataset (n = 4851 people with epilepsy and 20 428 controls). To assess the genetic overlap between these phenotypes, we performed genetic correlation analyses using linkage disequilibrium score regression, polygenic risk scores, and Mendelian randomization analyses.ResultsOur analyses show strong genetic correlations of genetic generalized epilepsy (GGE) with background EEG oscillations, primarily in the beta frequency band. Furthermore, we show that subjects with higher beta and theta polygenic risk scores have a significantly higher risk of having generalized epilepsy. Mendelian randomization analyses suggest a causal effect of GGE genetic liability on beta oscillations.SignificanceOur results point to shared biological mechanisms underlying background EEG oscillations and the susceptibility for GGE, opening avenues to investigate the clinical utility of background EEG oscillations in the diagnostic workup of epilepsy.
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- 2021
185. High Research Productivity During Orthopaedic Surgery Residency May Be Predicted by Number of Publications as a Medical Student
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Donley, Connor, McCrosson, Matthew, Prahad, Sri, Campbell, Collier, Zhao, Fei, Amireddy, Narcy, and Johnson, Michael
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- 2024
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186. Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking
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Schuller, Marion, Correy, Galen J, Gahbauer, Stefan, Fearon, Daren, Wu, Taiasean, Díaz, Roberto Efraín, Young, Iris D, Carvalho Martins, Luan, Smith, Dominique H, Schulze-Gahmen, Ursula, Owens, Tristan W, Deshpande, Ishan, Merz, Gregory E, Thwin, Aye C, Biel, Justin T, Peters, Jessica K, Moritz, Michelle, Herrera, Nadia, Kratochvil, Huong T, Aimon, Anthony, Bennett, James M, Brandao Neto, Jose, Cohen, Aina E, Dias, Alexandre, Douangamath, Alice, Dunnett, Louise, Fedorov, Oleg, Ferla, Matteo P, Fuchs, Martin R, Gorrie-Stone, Tyler J, Holton, James M, Johnson, Michael G, Krojer, Tobias, Meigs, George, Powell, Ailsa J, Rack, Johannes Gregor Matthias, Rangel, Victor L, Russi, Silvia, Skyner, Rachael E, Smith, Clyde A, Soares, Alexei S, Wierman, Jennifer L, Zhu, Kang, O’Brien, Peter, Jura, Natalia, Ashworth, Alan, Irwin, John J, Thompson, Michael C, Gestwicki, Jason E, von Delft, Frank, Shoichet, Brian K, Fraser, James S, and Ahel, Ivan
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Theory Of Computation ,Biochemistry and Cell Biology ,Biological Sciences ,Medicinal and Biomolecular Chemistry ,Chemical Sciences ,Information and Computing Sciences ,Bioengineering ,Coronaviruses ,Emerging Infectious Diseases ,Infectious Diseases ,5.1 Pharmaceuticals ,Catalytic Domain ,Crystallography ,X-Ray ,Humans ,Models ,Molecular ,Molecular Docking Simulation ,Protein Binding ,Protein Conformation ,SARS-CoV-2 ,Viral Nonstructural Proteins ,COVID-19 Drug Treatment ,QCRG Structural Biology Consortium - Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate-ribosylation signaling. This enzyme is a promising antiviral target because catalytic mutations render viruses nonpathogenic. Here, we report a massive crystallographic screening and computational docking effort, identifying new chemical matter primarily targeting the active site of the macrodomain. Crystallographic screening of 2533 diverse fragments resulted in 214 unique macrodomain-binders. An additional 60 molecules were selected from docking more than 20 million fragments, of which 20 were crystallographically confirmed. X-ray data collection to ultra-high resolution and at physiological temperature enabled assessment of the conformational heterogeneity around the active site. Several fragment hits were confirmed by solution binding using three biophysical techniques (differential scanning fluorimetry, homogeneous time-resolved fluorescence, and isothermal titration calorimetry). The 234 fragment structures explore a wide range of chemotypes and provide starting points for development of potent SARS-CoV-2 macrodomain inhibitors.
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- 2021
187. Comparison of mouse mammary gland imaging techniques and applications: Reflectance confocal microscopy, GFP Imaging, and ultrasound
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Cotarla Ion, Parrish Angela R, Tilli Maddalena T, Jones Laundette P, Johnson Michael D, and Furth Priscilla A
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Genetically engineered mouse models of mammary gland cancer enable the in vivo study of molecular mechanisms and signaling during development and cancer pathophysiology. However, traditional whole mount and histological imaging modalities are only applicable to non-viable tissue. Methods We evaluated three techniques that can be quickly applied to living tissue for imaging normal and cancerous mammary gland: reflectance confocal microscopy, green fluorescent protein imaging, and ultrasound imaging. Results In the current study, reflectance confocal imaging offered the highest resolution and was used to optically section mammary ductal structures in the whole mammary gland. Glands remained viable in mammary gland whole organ culture when 1% acetic acid was used as a contrast agent. Our application of using green fluorescent protein expressing transgenic mice in our study allowed for whole mammary gland ductal structures imaging and enabled straightforward serial imaging of mammary gland ducts in whole organ culture to visualize the growth and differentiation process. Ultrasound imaging showed the lowest resolution. However, ultrasound was able to detect mammary preneoplastic lesions 0.2 mm in size and was used to follow cancer growth with serial imaging in living mice. Conclusion In conclusion, each technique enabled serial imaging of living mammary tissue and visualization of growth and development, quickly and with minimal tissue preparation. The use of the higher resolution reflectance confocal and green fluorescent protein imaging techniques and lower resolution ultrasound were complementary.
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- 2008
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188. A Motivational Interviewing Intervention to Improve Adherence to ACEIs/ARBs among Nonadherent Older Adults with Comorbid Hypertension and Diabetes
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Mohan, Anjana, Majd, Zahra, Johnson, Michael L., Essien, Ekere J., Barner, Jamie, Serna, Omar, Gallardo, Esteban, Fleming, Marc L., Ordonez, Nancy, Holstad, Marcia M., and Abughosh, Susan M.
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- 2023
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189. A quasi-experimental test of an intervention to increase the use of thiazide-based treatment regimens for people with hypertension
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Beyth Rebecca J, Stanberry Elizabeth, Walder Annette, Johnson Michael L, Khan Myrna M, Ashton Carol M, Collins Tracie C, Gordon Howard S, Haidet Paul, Kimmel Barbara, Kolpakchi Anna, Lu Lee B, Naik Aanand D, Petersen Laura A, Singh Hardeep, and Wray Nelda P
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Medicine (General) ,R5-920 - Abstract
Abstract Background Despite recent high-quality evidence for their cost-effectiveness, thiazides are underused for controlling hypertension. The goal of this study was to design and test a practice-based intervention aimed at increasing the use of thiazide-based antihypertensive regimens. Methods This quasi-experimental study was carried out in general medicine ambulatory practices of a large, academically-affiliated Veterans Affairs hospital. The intervention group consisted of the practitioners (13 staff and 215 trainees), nurses, and patients (3,502) of the teaching practice; non-randomized concurrent controls were the practitioners (31 providers) and patients (18,292) of the non-teaching practices. Design of the implementation intervention was based on Rogers' Diffusion of Innovations model. Over 10.5 months, intervention teams met weekly or biweekly and developed and disseminated informational materials among themselves and to trainees, patients, and administrators. These teams also reviewed summary electronic-medical-record data on thiazide use and blood pressure (BP) goal attainment. Outcome measures were the proportion of hypertensive patients prescribed a thiazide-based regimen, and the proportion of hypertensive patients attaining BP goals regardless of regimen. Thirty-three months of time-series data were available; statistical process control charts, change point analyses, and before-after analyses were used to estimate the intervention's effects. Results Baseline use of thiazides and rates of BP control were higher in the intervention group than controls. During the intervention, thiazide use and BP control increased in both groups, but changes occurred earlier in the intervention group, and primary change points were observed only in the intervention group. Overall, the pre-post intervention difference in proportion of patients prescribed thiazides was greater in intervention patients (0.091 vs. 0.058; p = 0.0092), as was the proportion achieving BP goals (0.092 vs. 0.044; p = 0.0005). At the end of the implementation period, 41.4% of intervention patients were prescribed thiazides vs. 30.6% of controls (p < 0.001); 51.6% of intervention patients had achieved BP goals vs. 44.3% of controls (p < 0.001). Conclusion This multi-faceted intervention appears to have resulted in modest improvements in thiazide prescribing and BP control. The study also demonstrates the value of electronic medical records for implementation research, how Rogers' model can be used to design and launch an implementation strategy, and how all members of a clinical microsystem can be involved in an implementation effort.
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- 2007
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190. SBEAMS-Microarray: database software supporting genomic expression analyses for systems biology
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Campbell David, Moss Patrick, Deutsch Eric W, Marzolf Bruz, Johnson Michael H, and Galitski Timothy
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Biology (General) ,QH301-705.5 - Abstract
Abstract Background The biological information in genomic expression data can be understood, and computationally extracted, in the context of systems of interacting molecules. The automation of this information extraction requires high throughput management and analysis of genomic expression data, and integration of these data with other data types. Results SBEAMS-Microarray, a module of the open-source Systems Biology Experiment Analysis Management System (SBEAMS), enables MIAME-compliant storage, management, analysis, and integration of high-throughput genomic expression data. It is interoperable with the Cytoscape network integration, visualization, analysis, and modeling software platform. Conclusion SBEAMS-Microarray provides end-to-end support for genomic expression analyses for network-based systems biology research.
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- 2006
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191. Universal Polarimetric Signatures of the Black Hole Photon Ring
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Himwich, Elizabeth, Johnson, Michael D., Lupsasca, Alexandru, and Strominger, Andrew
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General Relativity and Quantum Cosmology ,Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Theory - Abstract
Black hole images present an annular region of enhanced brightness. In the absence of propagation effects, this "photon ring" has universal features that are completely governed by general relativity and independent of the details of the emission. Here, we show that the polarimetric image of a black hole also displays universal properties. In particular, the photon ring exhibits a self-similar pattern of polarization that encodes the black hole spin. We explore the corresponding universal polarimetric signatures of the photon ring on long interferometric baselines, and propose a method for measuring the black hole spin using a sparse interferometric array. These signatures could enable spin measurements of the supermassive black hole in M87, as well as precision tests of general relativity in the strong field regime, via a future extension of the Event Horizon Telescope to space., Comment: 13 pages, 4 figures
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- 2020
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192. Four Years in Review: Statistical Practices of Likert Scales in Human-Robot Interaction Studies
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Schrum, Mariah L., Johnson, Michael, Ghuy, Muyleng, and Gombolay, Matthew C.
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Computer Science - Human-Computer Interaction ,Computer Science - Robotics ,Statistics - Applications ,Statistics - Methodology - Abstract
As robots become more prevalent, the importance of the field of human-robot interaction (HRI) grows accordingly. As such, we should endeavor to employ the best statistical practices. Likert scales are commonly used metrics in HRI to measure perceptions and attitudes. Due to misinformation or honest mistakes, most HRI researchers do not adopt best practices when analyzing Likert data. We conduct a review of psychometric literature to determine the current standard for Likert scale design and analysis. Next, we conduct a survey of four years of the International Conference on Human-Robot Interaction (2016 through 2019) and report on incorrect statistical practices and design of Likert scales. During these years, only 3 of the 110 papers applied proper statistical testing to correctly-designed Likert scales. Our analysis suggests there are areas for meaningful improvement in the design and testing of Likert scales. Lastly, we provide recommendations to improve the accuracy of conclusions drawn from Likert data.
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- 2020
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193. Image-guided subject-specific modeling of glymphatic transport and amyloid deposition
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Johnson, Michael J., Abdelmalik, Michael R.A., Baidoo, Frimpong A., Badachhape, Andrew, Hughes, Thomas J.R., and Hossain, Shaolie S.
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- 2023
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194. Ion exchange and advanced oxidation/reduction processes for per- and polyfluoroalkyl substances treatment: a mini-review
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Banayan Esfahani, Ehsan, Dixit, Fuhar, Asadi Zeidabadi, Fatemeh, Johnson, Michael R, Mayilswamy, Neelambhigai, Kandasubramanian, Balasubramanian, and Mohseni, Madjid
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- 2023
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195. Comparison of Perioperative and Long-term Outcomes Following PEEK and Autologous Cranioplasty: A Single Institution Experience and Review of the Literature
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Anderson, Bradley, Harris, Peter, Mozaffari, Khashayar, Foster, Chase H., Johnson, Michael, Jaco, Alejandro A., and Rosner, Michael K.
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- 2023
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196. Use of Machine Learning to Screen for Acute Respiratory Distress Syndrome Using Raw Ventilator Waveform Data
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Rehm, Gregory B, Cortés-Puch, Irene, Kuhn, Brooks T, Nguyen, Jimmy, Fazio, Sarina A, Johnson, Michael A, Anderson, Nicholas R, Chuah, Chen-Nee, and Adams, Jason Y
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Biomedical and Clinical Sciences ,Clinical Sciences ,Patient Safety ,Assistive Technology ,Machine Learning and Artificial Intelligence ,Acute Respiratory Distress Syndrome ,Rare Diseases ,Lung ,Bioengineering ,4.2 Evaluation of markers and technologies ,7.3 Management and decision making ,Respiratory ,acute respiratory distress syndrome ,classification ,critical care ,mechanical ventilation ,population surveillance ,respiratory failure ,Clinical sciences - Abstract
To develop and characterize a machine learning algorithm to discriminate acute respiratory distress syndrome from other causes of respiratory failure using only ventilator waveform data.DesignRetrospective, observational cohort study.SettingAcademic medical center ICU.PatientsAdults admitted to the ICU requiring invasive mechanical ventilation, including 50 patients with acute respiratory distress syndrome and 50 patients with primary indications for mechanical ventilation other than hypoxemic respiratory failure.InterventionsNone.Measurements and main resultsPressure and flow time series data from mechanical ventilation during the first 24-hours after meeting acute respiratory distress syndrome criteria (or first 24-hr of mechanical ventilation for non-acute respiratory distress syndrome patients) were processed to extract nine physiologic features. A random forest machine learning algorithm was trained to discriminate between the patients with and without acute respiratory distress syndrome. Model performance was assessed using the area under the receiver operating characteristic curve, sensitivity, specificity, positive predictive value, and negative predictive value. Analyses examined performance when the model was trained using data from the first 24 hours and tested using withheld data from either the first 24 hours (24/24 model) or 6 hours (24/6 model). Area under the receiver operating characteristic curve, sensitivity, specificity, positive predictive value, and negative predictive value were 0.88, 0.90, 0.71, 0.77, and 0.90 (24/24); and 0.89, 0.90, 0.75, 0.83, and 0.83 (24/6).ConclusionsUse of machine learning and physiologic information derived from raw ventilator waveform data may enable acute respiratory distress syndrome screening at early time points after intubation. This approach, combined with traditional diagnostic criteria, could improve timely acute respiratory distress syndrome recognition and enable automated clinical decision support, especially in settings with limited availability of conventional diagnostic tests and electronic health records.
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- 2021
197. The promise of copper ionophores as antimicrobials
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O’Brien, Henrik, Davoodian, Talish, and Johnson, Michael D L
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- 2023
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198. Gene Expression Signatures in Inflammatory and Sclerotic Morphea Skin and Sera Distinguish Morphea from Systemic Sclerosis
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Chen, Henry W., Zhu, Jane L., Martyanov, Viktor, Tsoi, Lam C., Johnson, Michael E., Barber, Grant, Popovich, Dillon, O’Brien, Jack C., Coias, Jennifer, Cyrus, Nika, Malviya, Neeta, Florez-Pollack, Stephanie, Kunzler, Elaine, Hosler, Gregory A., Gudjonsson, Johann E., Khanna, Dinesh, Whitfield, Michael, and Jacobe, Heidi T.
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- 2023
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199. Detailed Abundances in the Ultra-faint Magellanic Satellites Carina II and III
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Ji, Alexander P., Li, Ting S., Simon, Joshua D., Marshall, Jennifer, Vivas, Kathy, Pace, Andrew B., Bechtol, Keith, Drlica-Wagner, Alex, Koposov, Sergey E., Hansen, Terese T., Allam, Sahar, Gruendl, Robert A., Johnson, Michael D., McNanna, Mitch, Noel, Noelia E. De., Tucker, Douglas L., Walker, Alistair R., and Collaboration, MagLiteS
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present the first detailed elemental abundances in the ultra-faint Magellanic satellite galaxies Carina II (Car II) and Carina III (Car III). With high-resolution Magellan/MIKE spectroscopy, we determined abundances of nine stars in Car II including the first abundances of an RR Lyrae star in an ultra-faint dwarf galaxy; and two stars in Car III. The chemical abundances demonstrate that both systems are clearly galaxies and not globular clusters. The stars in these galaxies mostly display abundance trends matching those of other similarly faint dwarf galaxies: enhanced but declining [alpha/Fe] ratios, iron-peak elements matching the stellar halo, and unusually low neutron-capture element abundances. One star displays a low outlying [Sc/Fe] = -1.0. We detect a large Ba scatter in Car II, likely due to inhomogeneous enrichment by low-mass AGB star winds. The most striking abundance trend is for [Mg/Ca] in Car II, which decreases from +0.4 to -0.4 and indicates clear variation in the initial progenitor masses of enriching core-collapse supernovae. So far, the only ultra-faint dwarf galaxies displaying a similar [Mg/Ca] trend are likely satellites of the Large Magellanic Cloud. We find two stars with [Fe/H] < -3.5, whose abundances likely trace the first generation of metal-free Population III stars and are well-fit by Population III core-collapse supernova yields. An appendix describes our new abundance uncertainty analysis that propagates line-by-line stellar parameter uncertainties., Comment: 21 pages + appendix, 9 figures, 6 tables, accepted to ApJ
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- 2019
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200. Regression with Uncertainty Quantification in Large Scale Complex Data
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Wilkins, Nicholas, Johnson, Michael, and Nwogu, Ifeoma
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Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
While several methods for predicting uncertainty on deep networks have been recently proposed, they do not readily translate to large and complex datasets. In this paper we utilize a simplified form of the Mixture Density Networks (MDNs) to produce a one-shot approach to quantify uncertainty in regression problems. We show that our uncertainty bounds are on-par or better than other reported existing methods. When applied to standard regression benchmark datasets, we show an improvement in predictive log-likelihood and root-mean-square-error when compared to existing state-of-the-art methods. We also demonstrate this method's efficacy on stochastic, highly volatile time-series data where stock prices are predicted for the next time interval. The resulting uncertainty graph summarizes significant anomalies in the stock price chart. Furthermore, we apply this method to the task of age estimation from the challenging IMDb-Wiki dataset of half a million face images. We successfully predict the uncertainties associated with the prediction and empirically analyze the underlying causes of the uncertainties. This uncertainty quantification can be used to pre-process low quality datasets and further enable learning.
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- 2019
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