1,228 results on '"Julius K"'
Search Results
152. Structure of ATP synthase from ESKAPE pathogen Acinetobacter baumannii
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Demmer, Julius K., primary, Phillips, Ben P., additional, Uhrig, O. Lisa, additional, Filloux, Alain, additional, Allsopp, Luke P., additional, Bublitz, Maike, additional, and Meier, Thomas, additional
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- 2022
- Full Text
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153. Distal partial ulnectomy with ulnar styloid process excision for management of an aneurysmal bone cyst in a cat
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Carlos Sanchez Villamil, Cesar Llanos Diez, Grace Thomas, Rachel Garty, Marianne Lappalainen, Julius Klever, and Alexandros Hardas
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Veterinary medicine ,SF600-1100 - Abstract
Case summary An 8-year-old male neutered domestic shorthair cat was presented with an acute onset of left thoracic limb lameness and a firm swelling on the lateral aspect of the left distal antebrachium. A CT scan of the left thoracic limb revealed an expansile osteolytic cystic bone lesion centred at the distal left ulnar metaphysis. Cytology from fine-needle aspiration was not consistent with neoplasia. The CT features and the cytology results were suggestive of a bone cyst. A distal partial ulnectomy with ulnar styloid process excision was performed as the biopsy method and as the treatment approach. Histopathology results were consistent with an aneurysmal bone cyst (ABC). Carpal instability was not detected after distal partial ulnectomy; therefore, a stabilisation method was not required. Limb function was excellent after surgery, with no lameness and no recurrence detected by the owner at 2, 6 and 24 weeks postoperatively. The veterinary examination at 12 weeks postoperatively confirmed the owner’s outcome assessment. Relevance and novel information To the authors’ knowledge, this is the first report describing a distal partial ulnectomy with ulnar styloid process excision in a cat. Despite disrupting the short ulnar collateral ligament, this technique provided excellent short-term limb function with no need for carpal joint stabilisation. This technique allowed for the complete excision of a distal ulnar ABC and avoided cyst debridement, which could be associated with haemorrhage, recurrence and malignant transformation. Distal partial ulnectomy should be considered for distal ulnar bone lesions in cats.
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- 2024
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154. Effect of gamma irradiation on proliferation and growth of friable embryogenic callus and in vitro nodal cuttings of ugandan cassava genotypes
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Hellen B. Apio, Wilfred Elegba, Wonder Nunekpeku, Solomon Ayeboafo Otu, Julius Karubanga Baguma, Titus Alicai, Kenneth Ellis Danso, Isaac Kofi Bimpong, and Emmanuel Ogwok
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cassava genotypes ,gamma radiation ,friable embryogenic callus ,in vitro nodal cuttings ,mutation induction ,Plant culture ,SB1-1110 - Abstract
Cassava (Manihot esculenta Crantz) production and productivity in Africa is affected by two viral diseases; cassava mosaic disease (CMD) and cassava brown streak disease (CBSD). Induced mutagenesis of totipotent/embryogenic tissues or in vitro plant material can lead to the generation of CMD and/or CBSD tolerant mutants. To massively produce non-chimeric plants timely and with less labor, totipotent cells or tissues are a pre-requisite. This study aimed to determine the effect of gamma radiation on the proliferation and growth of friable embryogenic callus (FEC) and in vitro nodal cuttings respectively. To obtain FEC, 2-6 mm sized leaf lobes of nine cassava genotypes were plated on Murashige and Skoog (MS) basal media supplemented with varying levels (37, 50, 70, 100) μM of picloram for production of organized embryogenic structures (OES). The OES of five cassava genotypes (Alado, CV-60444, NASE 3, NASE 13 and TME 204) were crushed and plated in Gresshoff and Doy (GD) basal media in combination with the amino acid tyrosine in varying concentrations for FEC production. FEC from five cassava genotypes and in vitro nodal cuttings of nine genotypes were irradiated using five different gamma doses (0, 5, 10, 15, 20 and 25 Gy) at a dose rate of 81Gy/hr. The lethal dose (LD)50 was determined using the number of roots produced and flow cytometry was done to determine the ploidy status of plants. The highest production of OES was noted in Alado across varying picloram concentrations, while TME 204 obtained the highest amount of FEC. The irradiated FEC gradually died and by 28 days post irradiation, FEC from all five cassava genotypes were lost. Conversely, the irradiated in vitro nodal cuttings survived and some produced roots, while others produced callus. The LD50 based on number of roots varied from genotype to genotype, but plants remained diploid post-irradiation. Accordingly, the effect of gamma irradiation on Ugandan cassava genotypes (UCGs) was genotype-dependent. This information is foundational for the use of in vitro tissues as target material for cassava mutation breeding.
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- 2024
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155. A landscape analysis of clinical trials and infant clinical trials in Kenya, Ethiopia, and Nigeria
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Patrick Amboka, Daniel Kurui, Marylene Wamukoya, Julius Kirimi Sindi, and Marta Vicente-Crespo
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clinical research ,infant and intervention clinical trials ,RCT ,LMIC ,randomized trials ,existing capacity ,Infectious and parasitic diseases ,RC109-216 - Abstract
IntroductionGlobal inequality in clinical research capacity and service delivery can be indicated simply by the proportion of clinical trials that a country or region has registered in clinical trial registry databases. The proportion of clinical trials registered in Africa is very low at 0.02%, even though the region accounts for approximately 15% of the world's population. Despite the economic challenges in most African countries, they have shown potential for growth and change in recent years.MethodsWe conducted desk reviews on the interventional clinical trials done in Kenya, Ethiopia, and Nigeria between 2015 to May 2023. The search was done in clinical trials repositories, and journal repositories. The search focused on intervention clinical trials. Data was extracted by screening through the publications and clinical trial platforms. The data extracted from the publications included the type of clinical trial, clinical trial phase, diseases, etc. The data extracted from the reports included: challenges in conducting clinical trials, capacity-building efforts, and the impact of the clinical trial.ResultsThe number of clinical trial studies identified in Kenya was 113 (28 were on infant clinical trials). The study identified 97 clinical trials in Nigeria, of which 11 studies were on infant clinical trials. In Ethiopia, there were 28 clinical trials and only five were on infant clinical trials. The landscape review also expanded to capacity and gaps in clinical trials in the three countries. The largest proportion of clinical trials carried out in Kenya was on injury, occupational disease, and poisoning, 30.5% (n = 18) and the smallest proportion was on kidney disease, neonatal disease, obstetrics, and gynecology. Most Infant clinical trials were carried out in the area of infections and infestations 33.3% (n = 7). Most of the challenges faced by clinical trials in the three countries include a lack of infrastructure, a lack of human resources, and a lack of financial resources.ImplicationsThere is a need to map clinical trials done by African researchers based in Africa to exclude the trials done by non-African researchers based in Africa. Opportunities for clinical trials should be supported and challenges addressed.
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- 2024
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156. The Relationship between ICT Adoption and Student Enrolment in TVET Institutions in Bungoma County, Kenya
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Juma Ingendi, Jayne Nasimiyu Wasike, and Julius K. Maiyo
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Economic growth ,Information and Communications Technology ,Business - Published
- 2020
157. Malaria Diagnosed in an Urban Setting Strongly Associated with Recent Overnight Travel: A Case–Control Study from Kampala, Uganda
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Moses R. Kamya, Emmanuel Arinaitwe, Victor Kamya, Chris Drakeley, Arthur Mpimbaza, Joaniter I. Nankabirwa, Grant Dorsey, Sarah G. Staedke, Julius K. Kuule, Alan Asiimwe, and Philip J. Rosenthal
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Male ,Adolescent ,030231 tropical medicine ,Indoor residual spraying ,Low transmission ,03 medical and health sciences ,0302 clinical medicine ,Virology ,parasitic diseases ,medicine ,Humans ,Uganda ,Insecticide-Treated Bednets ,Child ,Malaria epidemiology ,Travel ,Extramural ,business.industry ,Case-control study ,Articles ,medicine.disease ,Malaria ,Infectious Diseases ,Case-Control Studies ,Child, Preschool ,Female ,Parasitology ,Residence ,business ,human activities ,Demography - Abstract
Malaria is frequently diagnosed in urban Kampala, despite low transmission intensity. To evaluate the association between recent travel out of Kampala and malaria, we conducted a matched case–control study. Cases were febrile outpatients with a positive malaria test; controls were febrile outpatients with a negative test. For every two cases, five controls were selected, matching on age. Data were collected on recent overnight travel out of Kampala (past 60 days), destination and duration of travel, and behavioral factors, including sleeping under an insecticide-treated net (ITN) during travel. From July to August 2019, 162 cases and 405 controls were enrolled. The locations of residence of cases and controls were similar. More controls were female (62.7% versus 46.3%, P < 0.001). Overall, 158 (27.9%) participants reported recent overnight travel. Travelers were far more likely to be diagnosed with malaria than those who did not travel (80.4% versus 8.6%, OR 58.9, 95% CI: 23.1–150.1, P < 0.001). Among travelers, traveling to a district not receiving indoor residual spraying of insecticide (OR 35.0, 95% CI: 4.80–254.9, P < 0.001), no ITN use (OR 30.1, 95% CI: 6.37–142.7, P < 0.001), engaging in outdoor activities (OR 22.0, 95% CI: 3.42–141.8, P = 0.001), and age < 16 years (OR 8.36, 95% CI: 2.22–56.2, P = 0.03) were associated with increased odds of malaria. Kampala residents who traveled overnight out of the city were at substantially higher risk of malaria than those who did not travel. For these travelers, personal protection measures, including sleeping under an ITN when traveling, should be advocated.
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- 2020
158. The Relationship between Budget Adequacy and Student Enrolment in TVET Institutions in Bungoma County, Kenya
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Jayne Nasimiyu Wasike, Julius K. Maiyo, and Juma Ingendi
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- 2020
159. Late Neoproterozoic evolution of the southwestern margin of the Siberian Craton: evidence from sedimentology, geochronology and detrital zircon analysis
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Julius K. Sovetov, Mikhail Romanov, Simon A. Wilde, Nikolay Yu. Matushkin, Pavel I. Kadilnikov, Valery A. Vernikovsky, Gideon Rosenbaum, and Antonina E. Vernikovskaya
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Provenance ,geography ,geography.geographical_feature_category ,020209 energy ,Geochemistry ,Geology ,02 engineering and technology ,010502 geochemistry & geophysics ,01 natural sciences ,Craton ,Geochronology ,0202 electrical engineering, electronic engineering, information engineering ,Siliciclastic ,Sedimentary rock ,Sedimentology ,0105 earth and related environmental sciences ,Terrane ,Zircon - Abstract
Sedimentary successions and igneous rocks exposed in Eastern Sayan provide an important geological record on the tectonic evolution of the southwestern margin of the Siberian Craton during the Neoproterozoic. Here we present sedimentological and detrital zircon provenance data from key stratigraphic units, complemented by a new U-Pb zircon age of 718 ± 6 Ma from the mafic Nersa magmatic complex. Sedimentological and provenance data from the lower part of the stratigraphic succession (Karagasy Group) show that these rocks were deposited in a passive margin setting after 750 Ma and before the emplacement of the Nersa magmatic complex. The upper part of the stratigraphic succession (Oselok Group) consists of Cryogenian and Ediacaran glaciogenic deposits and associated cap carbonates, overlain by mid to late Ediacaran sequences of dominantly shallow-marine and fluvial siliciclastic rocks. Provenance data indicate that rocks from the Tuva-Mongolia and Zavkhan terranes provided a significant input of detrital material into the sedimentary basin that was the source of the glacial deposits. Orogenic processes during the late Ediacaran (ca 570–540 Ma) in Eastern Sayan were likely associated with the accretion of the Tuva-Mongolia terrane, as indicated by the detrital zircon data.
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- 2020
160. Antidepressant potential of butanol fraction of Milicia excelsa (Moraceae) leaf in mice
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Lateef Abiola Akinpelu, Theophilus Adekunle Adegbuyi, Idris Ajayi Oyemitan, Olaonipekun Julius K., Idowu Julius Olawuni, Gbola Olayiwola, and Samuel Sunday Agboola
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chemistry.chemical_compound ,Traditional medicine ,biology ,chemistry ,Butanol ,Milicia excelsa ,Fraction (chemistry) ,biology.organism_classification ,Moraceae - Published
- 2020
161. Volumetric modulated craniospinal irradiation workflow optimization through quantitative analytics: a single-institution case study comparing pediatric and adult settings
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Kenneth Wong, Leslie K. Ballas, Julian Sison, Barbara Lam, Nimit Dholakia, Julius K. Weng, Christophe Marques, Eric L. Chang, Steven Nguyen, Arthur J. Olch, and Jonathan Waxer
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Craniospinal Irradiation ,030218 nuclear medicine & medical imaging ,Workflow optimization ,Radiation therapy ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Analytics ,030220 oncology & carcinogenesis ,medicine ,Medical physics ,Single institution ,business ,Quality assurance ,Image-guided radiation therapy - Abstract
We used quantitative analytics to assess the efficiency of the clinical workflow for radiation therapy delivery in children and adults focusing on our experience with volumetric modulated arc therapy (VMAT) craniospinal irradiation (CSI). We retrospectively collected clinical and treatment specific data between June 2013 and November 2018 for 614 VMAT CSI sessions of 41 pediatric patients and 48 VMAT CSI sessions of 6 adult patients treated at two hospitals within the same academic institution. Descriptive statistics were generated and a multiple linear regression model was created to predict total radiation time (TRT) based on these predictors. Prolonged treatment sessions were filtered using the interquartile range outlier detection method for quality assurance review. The median pediatric TRT for all VMAT CSI treatment sessions was 21.07 min (interquartile range (IQR) 9.05). Pediatric patient height, fraction number (fractions 1–3 vs. fractions > 3), and number of isocenters were significant predictors for TRT (p
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- 2020
162. Published Operative Times Do Not Reflect Surgeon Effort: A Novel Approach for Calculating Operative Times in Total Hip Arthroplasty to Better Quantify Surgeon Work
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Harpal S. Khanuja, Syed A. Hasan, Yash P. Chaudhry, Mitchell A. Solano, Julius K. Oni, and Robert S. Sterling
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Adult ,Surgeons ,030222 orthopedics ,medicine.medical_specialty ,business.industry ,Arthroplasty, Replacement, Hip ,General surgery ,Operative Time ,03 medical and health sciences ,surgical procedures, operative ,0302 clinical medicine ,Hospital treatment ,Background current ,Humans ,Medicine ,Operative time ,Orthopedics and Sports Medicine ,Fellowships and Scholarships ,business ,Fellowship training ,Surgeon volume ,American society of anesthesiologists ,Total hip arthroplasty - Abstract
Background Current estimates of operative time (OT) for total hip arthroplasty (THA) are reported as the mean OT across all procedures. This method does not reflect variability among surgeons and surgical settings and should not be used to infer individual surgeon work. We hypothesized that this method would underestimate the time it takes individual surgeons to perform THA. Therefore, we compared the mean OT for all THA cases (“overall OT”) with the mean OT for individual surgeons (“individual surgeon OT”) and examined which factors were associated with each. Methods Mean OT was calculated for 3972 primary THA cases (“overall OT”) by 41 surgeons from 2015 to 2018 in a single health system. The mean OT for each surgeon was determined (“individual surgeon OT”), averaged across surgeons, and compared with overall OT. Overall OT and individual surgeon OT were assessed for associations with surgeon-related (adult reconstruction fellowship training, THA volume, years’ experience), hospital-related (hospital type, trainee presence), and patient-related (age, body mass index category, American Society of Anesthesiologists physical status classification) factors (alpha = 0.05). Results Mean individual surgeon OT was significantly longer (106 ± 21 minutes) than overall OT (96 ± 28 minutes) (P = .03), with 73% of individual surgeon OTs being greater than overall OT. Although all surgeon-, hospital-, and patient-related factors were associated with significant differences in overall OT, only hospital type was associated with differences in individual surgeon OT. Conclusion Individual surgeon OT was longer than overall OT for most surgeons and provides a better estimate of surgeon work.
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- 2020
163. Hypoglycemic, hypolipidemic, and hepatoprotective effects of Polyscias fulva (Hiern) Harms ethanolic bark extract in streptozotocin-induced diabetic Wistar rats
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Lucia Keter, Julius K. Koech, Benson N. Macharia, Vivian C. Tuei, Nicholas Mwikwabe, and Anastasia N. Nandwa
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medicine.diagnostic_test ,Globulin ,biology ,business.industry ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Intraperitoneal injection ,Pharmacology ,Malondialdehyde ,medicine.disease ,Streptozotocin ,Metformin ,chemistry.chemical_compound ,chemistry ,Diabetes mellitus ,Internal Medicine ,medicine ,biology.protein ,Alkaline phosphatase ,Lipid profile ,business ,medicine.drug - Abstract
Polyscias fulva (Hiern) Harms stem bark is used in traditional folk medicine in Kenya for diabetes mellitus and obesity management. This study sought to examine the antidiabetic effects of ethanolic stem bark extract of P. fulva in streptozotocin (STZ)–induced diabetic Wistar albino rats. Diabetes in rats was induced by intraperitoneal injection of STZ (50 mg/kg bwt) in experimental groups. Rats were divided into five groups (n = 5 per group): group 1, control; group 2, diabetic untreated rats; groups 3 and 4, diabetic rats on 200 and 400 mg/kg bwt/day of extract, respectively; and group 5, diabetic rats on metformin (100 mg/kg bwt/day). The rats received oral treatments daily for 21 days, and fasting blood glucose levels and body weights were determined weekly. Liver histopathological analysis and malondialdehyde (MDA) assay as well as serum analysis of lipid profile, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total proteins (TP), albumin (ALB), and globulins were performed at the end of the treatment period. Extract had significant hypoglycemic and hypolipidemic effects in the diabetic rats compared with diabetic untreated rats (p
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- 2020
164. Automated detection & classification of knee arthroplasty using deep learning
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Julius K. Oni, Ferdinand K. Hui, Paul H. Yi, Tae Kyung Kim, Haris I. Sair, Gregory D. Hager, Jan Fritz, and Jinchi Wei
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Male ,Reoperation ,musculoskeletal diseases ,Knee Joint ,medicine.medical_treatment ,Radiography ,Total knee arthroplasty ,Prosthesis ,Decision Support Techniques ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Deep Learning ,0302 clinical medicine ,medicine ,Humans ,Orthopedics and Sports Medicine ,Femoral component ,Arthroplasty, Replacement, Knee ,Unicompartmental knee arthroplasty ,Aged ,Orthodontics ,030222 orthopedics ,Receiver operating characteristic ,business.industry ,Deep learning ,Middle Aged ,Osteoarthritis, Knee ,musculoskeletal system ,Arthroplasty ,Treatment Outcome ,Female ,Artificial intelligence ,business - Abstract
Background Preoperative identification of knee arthroplasty is important for planning revision surgery. However, up to 10% of implants are not identified prior to surgery. The purposes of this study were to develop and test the performance of a deep learning system (DLS) for the automated radiographic 1) identification of the presence or absence of a total knee arthroplasty (TKA); 2) classification of TKA vs. unicompartmental knee arthroplasty (UKA); and 3) differentiation between two different primary TKA models. Method We collected 237 anteroposterior (AP) knee radiographs with equal proportions of native knees, TKA, and UKA and 274 AP knee radiographs with equal proportions of two TKA models. Data augmentation was used to increase the number of images for deep convolutional neural network (DCNN) training. A DLS based on DCNNs was trained on these images. Receiver operating characteristic (ROC) curves with area under the curve (AUC) were generated. Heatmaps were created using class activation mapping (CAM) to identify image features most important for DCNN decision-making. Results DCNNs trained to detect TKA and distinguish between TKA and UKA both achieved AUC of 1. Heatmaps demonstrated appropriate emphasis of arthroplasty components in decision-making. The DCNN trained to distinguish between the two TKA models achieved AUC of 1. Heatmaps showed emphasis of specific unique features of the TKA model designs, such as the femoral component anterior flange shape. Conclusions DCNNs can accurately identify presence of TKA and distinguish between specific arthroplasty designs. This proof-of-concept could be applied towards identifying other prosthesis models and prosthesis-related complications.
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- 2020
165. Management of Flash Floods in Marigat Sub County, Baringo County, Kenya
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Julius K. Kiptim, Eliud Michura, and Ednah Koskei
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Flash flood is a natural disaster caused by the sudden onset of rainfall resulting in runoff waters from high to low altitude areas. This runoff waters leads to loss of lives, destruction of property, and environment; a problem experienced by residents of Marigat Sub-County. The purpose of the study was to investigate the management strategies of flash floods in Marigat Sub-County. The study used descriptive research management practices of flash floods on qualitative and quantitative methods. The target population was 120,263 people with 24,893 households. Purposive sampling method for three locations which were Ilng’arua, Ng’ambo and Salabani experiencing flash floods with a population of 13,885 translating to 3168 households, from which a sample size of 355 respondents was obtained. Stratified proportionate random sampling method was used to select household heads for the survey. Purposive sampling method was adopted for identifying key informants and one disaster management officer. Primary and secondary data were used. Questionnaires, key informants interview schedules, and observations were used to collect data. The validity of the study was achieved through the construction of relevant instruments to the objective of the study. To ensure reliability, piloting of the questionnaire was done and results obtained were 0.76 Cronbach’s alpha level. Collected data were coded and analysed using the SPSS software, where descriptive and inferential statistics were generated to test the study hypothesis. The findings of this study will be beneficial to Baringo County and the Kenyan government in the management of flash floods and the achievement of sustainable development goals.
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- 2020
166. Determining a preoperative international normalised ratio threshold safe for hip fracture surgery
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Kevin L Mekkawy, Yash P Chaudhry, John G Mawn, Aoife MacMahon, Julius K Oni, Robert S Sterling, Rachel B Sotsky, and Harpal S Khanuja
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Orthopedics and Sports Medicine ,Surgery - Abstract
Introduction: The purpose of this study was first, to assess the relationship between preoperative INR (international normalised ratio) and postoperative complication rates in patients with a hip fracture, and second, to establish a threshold for INR below which the risk of complications is comparable to those in patients with a normal INR. Methods: We retrospectively reviewed the American College of Surgeons National Surgical Quality Improvement Program and found 35,910 cases who had undergone surgery for a hip fracture between 2012 and 2018. Cases were stratified into 4 groups based on their preoperative INR levels: Results: Of the 35,910 cases, 33,484 (93.2%) had a preoperative INR Conclusions: We found that an INR of
- Published
- 2023
167. Surgeon Mean Operative Times in Total Knee Arthroplasty in a Variety of Settings in a Health System
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Mitchell A. Solano, Harpal S. Khanuja, Julius K. Oni, Lynne C. Jones, Yash P. Chaudhry, and Robert S. Sterling
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030222 orthopedics ,Surgical team ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,General surgery ,Total knee arthroplasty ,Retrospective cohort study ,Overweight ,Arthroplasty ,03 medical and health sciences ,0302 clinical medicine ,Orthopedic surgery ,medicine ,Operative time ,Orthopedics and Sports Medicine ,Mass index ,medicine.symptom ,business - Abstract
Background High-quality care is essential in total joint arthroplasty. Multiple initiatives such as centers of excellence, patient optimization, and alternative payment models have demonstrated improved outcomes and decreased cost. Many studies have shown that longer operative times (OTs) are associated with increased frequency of postoperative complications. These findings often come from large data sets and may not accurately represent the average OT of individual surgeons. The purpose of this study was to determine the hospital and patient-related factors that influence OT. Methods This retrospective study reviewed OT of 6003 total knee arthroplasty cases performed by 41 surgeons at 4 hospitals in a single health-care system. Mean OT was calculated for each surgeon. The effect of surgeon, hospital-, and patient-related factors on OT was assessed. Results Among the 41 surgeons, the mean OT was 105 ± 25 minutes. Two community hospitals had significantly faster OT compared with the tertiary care academic hospital. Surgeons’ OT for morbidly obese patients was significantly longer compared with normal, overweight, and obese patients. Surgeon volume, surgeon experience, trainee presence, and American Society of Anesthesiologists status did not significantly affect surgical time. Conclusions Operative time was influenced by hospital-related (tertiary, community) and patient-related (morbid obesity vs lower body mass index groups) factors. However, specific surgeon factors (surgical volume, experience), surgical team factors (presence or absence of trainee), and patient factors (American Society of Anesthesiologists status) did not significantly alter the OT. Additional studies of larger health systems are needed to examine additional patient, surgeon, and hospital factors which may influence the OT.
- Published
- 2019
168. Performance Contracting and Service Delivery in Public Secondary Schools in Trans-Nzoia County, Kenya
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Mary Maruti, Julius K. Maiyo, and Jane Barasa
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- 2021
169. Structure of ATP synthase from ESKAPE pathogen Acinetobacter baumannii
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Julius K. Demmer, Ben P. Phillips, O. Lisa Uhrig, Alain Filloux, Luke P. Allsopp, Maike Bublitz, Thomas Meier, and Wellcome Trust
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Multidisciplinary Sciences ,MODEL ,STRAIN ,Multidisciplinary ,Science & Technology ,TARGET ,RANGE ,Science & Technology - Other Topics ,VISUALIZATION ,CRYO-EM ,ANTIBIOTICS - Abstract
The global spread of multidrug-resistant Acinetobacter baumannii infections urgently calls for the identification of novel drug targets. We solved the electron cryo-microscopy structure of the F 1 F o –adenosine 5′-triphosphate (ATP) synthase from A. baumannii in three distinct conformational states. The nucleotide-converting F 1 subcomplex reveals a specific self-inhibition mechanism, which supports a unidirectional ratchet mechanism to avoid wasteful ATP consumption. In the membrane-embedded F o complex, the structure shows unique structural adaptations along both the entry and exit pathways of the proton-conducting a-subunit. These features, absent in mitochondrial ATP synthases, represent attractive targets for the development of next-generation therapeutics that can act directly at the culmination of bioenergetics in this clinically relevant pathogen.
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- 2021
170. Antidiarrheal activity of Bridelia ferruginea bark methanolic extract involves modulation ATPases in mice and inhibition of muscarinic acetylcholine receptor (M3) and prostaglandin E2 receptor 3 (EP3) in silico
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Ahmed Adebayo Ishola, Francis O Akingbule, Yetunde Ayoka Ipadeola, Adeoti Gbemisola Adegoke, Julius K. Adesanwo, Blessing O. Omolaso, and Kayode Ezekiel Adewole
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Phenol red ,Stigmasterol ,biology ,Chemistry ,Prostaglandin E2 receptor ,ATPase ,Motility ,Pharmacology ,chemistry.chemical_compound ,Diarrhea ,Complementary and alternative medicine ,visual_art ,Muscarinic acetylcholine receptor ,visual_art.visual_art_medium ,medicine ,biology.protein ,Bark ,medicine.symptom - Abstract
Objectives Diarrhea, an abnormal state in which the individual has about three or more daily bowel movements, is now considered one of the most challenging global public health problems. Using plant products, such as Bridelia ferruginea is an alternative treatment option. The objective of this study was to investigate the antidiarrheal activity of B. ferruginea bark methanolic extract (BfME) and the mechanisms involved. Methods BfME antidiarrheal activity was evaluated in mice model of castor oil-induced diarrhea and enteropooling. To evaluate motility, gastrointestinal transit time was carried out using phenol red meal, while intestinal activities of selected ATPases were also evaluated. Furthermore, the active components in BfME were detected by GC-MS analysis, while molecular docking of the most abundant compounds with muscarinic acetylcholine receptor (M3) and prostaglandin E2 receptor 3 (EP3) were conducted. Results BfME at 400 and 800 mg/kg showed antidiarrheal activity by delaying onset of diarrhea, reduced gastrointestinal transit and increased intestinal activities of Na+ K+-ATPase, Ca2+ Mg2+-ATPase and Mg2+-ATPase. Molecular docking revealed that γ-sitosterol, α-amyrin, and stigmasterol have outstanding binding affinity for M3 and EP3. Conclusions In view of these results, the observed antidiarrheal activity possibly occurs via the activation of ATPases activities and inhibition of M3 and EP3.
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- 2021
171. Anti-inflammatory and Analgesic Properties of Ethanolic Stem Bark Extract of Ficus trichopoda in Rats.
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Ajayi, Abayomi M, Tanayena, Julius K, Balogun, Sikiru O, Ibrahim, Aminu, Ezeonwumelu, Joseph OC, Kiplagat, David, Oyewale, Abdulwaheed A, Oloro, Joseph O, Goji, Anthony DT, and Adzu, Bulus
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- 2011
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172. Performance Contracting and Service Delivery in Public Secondary Schools in Trans-Nzoia County, Kenya
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Maruti, Mary, primary, Maiyo, Julius K., additional, and Barasa, Jane, additional
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- 2021
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173. AMINO ACID COMPOSITION AND ANTI-TYROSINASE ACTIVITY OF METABOLITES FROM EDIBLE Pleurotus SPECIES FOR THEIR NUTRITIONAL AND THERAPEUTIC POTENTIAL
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Omomowo, Iyabo O., primary, Bamigboye, Comfort O., additional, Omomowo, Olawale I., additional, Majolagbe, Olusola N., additional, Ogundola, Adijat F., additional, and Oloke, Julius K., additional
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- 2021
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174. Increased Patient-Level Payment After Removal of Total Knee Arthroplasty From the Inpatient-Only List
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Aoife MacMahon, Syed A. Hasan, Mayank Patel, Julius K. Oni, Harpal S. Khanuja, and Robert S. Sterling
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Inpatients ,Arthroplasty, Replacement, Hip ,Humans ,Orthopedics and Sports Medicine ,Length of Stay ,Arthroplasty, Replacement, Knee ,Medicare ,Centers for Medicare and Medicaid Services, U.S ,United States ,Aged ,Retrospective Studies - Abstract
In January 2018, the Centers for Medicare and Medicaid Services removed total knee arthroplasty (TKA) from the Inpatient Only (IPO) list. This study aimed to compare patient-level payments in TKA cases with a length of stay (LOS)2 midnights before and after removal of TKA from IPO list.In this retrospective cohort study, all Medicare patients who received a primary elective TKA from 2016-2019 with a LOS2 midnights at an academic tertiary center were identified. Total and itemized charges and patient-level payments were compared between eligible TKA cases performed in 2016-2017 and those in 2018-2019. There were 351 eligible TKA cases identified: 151 in 2016-2017 and 200 in 2018-2019.The percentage of patients making any out-of-pocket payment increased in 2018-2019 from 2016-2017 (51.0% versus 10.6%), as did median patient-level payment ($7.30 [range, $0.00-$3,389] versus $0.00 [range, $0.00-$1,248], P.001 for both). A greater proportion of patients in 2018-2019 paid $1-$50 than in 2016-2017 (37.5% versus 1.3%, P.001) with no change in the proportion of patients who made payments$50. Total charges were less in 2018-2019 than in 2016-2017 (P = .001). Charges for drugs, laboratory tests, admissions/floor, and therapies decreased in 2018-2019, whereas charges for the operating room and radiology increased (P.001 for all).Patients receiving outpatient TKA in 2018-2019 were more likely to have out-of-pocket payments than patients with comparable hospital stay who were designated as inpatients, although most of these payments were less than $50.
- Published
- 2021
175. Predictors and Outcomes of Postoperative Hemoglobin of8 g/dL in Total Joint Arthroplasty
- Author
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Julius K. Oni, Sandesh S. Rao, Robert S. Sterling, Aoife MacMahon, Kevin Mekkawy, Yash P Chaudhry, Gregory R. Toci, and Harpal S. Khanuja
- Subjects
Adult ,Male ,Blood management ,Anemia ,Arthroplasty, Replacement, Hip ,Blood Loss, Surgical ,Hemoglobins ,Risk Factors ,Medicine ,Humans ,Orthopedics and Sports Medicine ,Blood Transfusion ,Postoperative Period ,Arthroplasty, Replacement, Knee ,Aged ,Receiver operating characteristic ,business.industry ,Anticoagulants ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,Anesthesia ,Surgery ,Female ,Hemoglobin ,business ,Body mass index ,Tranexamic acid ,medicine.drug - Abstract
BACKGROUND Restrictive transfusion practices have decreased transfusions in total joint arthroplasty (TJA). A hemoglobin threshold of
- Published
- 2021
176. Potentials of Mangifera Indica Seed Oil Extract as Bio-preservative Against Termite Attack on Wood
- Author
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Okanlawon, Funmilayo B., Adegoke, Olaoluwa A., Olatunji, Oladayo A., and Abiola, Julius K.
- Subjects
food and beverages - Abstract
The need for preservation of wood to prolong it serviceable life is necessary and thus developing a new safer ecofriendly preservative is of importance because of the damages caused by the chemical preservatives. This study, therefore, investigates the bio preservative potentials of Mangifera indica seed oil extract against termite attack on Triplochiton scleroxcylon and Terminalia superba wood. The pods of M. indica were collected and dehulled after which the seeds were removed from the pods, sundried, and blended to fine powder. The fine cotyledon was subjected to solvent extraction for oil using a Soxhlet apparatus and N-hexane as the solvent. Data collected was analyzed using simple statistics and analysis of variance at α = 0.05. The wood was dimensioned into 5 x 5 x 30 cm and 200 ml of seed oil was applied to it using a brush. The treated wood was exposed to field termites and the absorption rate and weight loss to termite attack were determined. Data collected were analysed with t-test at α = 0.05. The percentage weight loss of wood samples due to T. scleroxcylon and T. superba were 13.76 and 11.52 % respectively. These values are lower than the mean values obtained for the control (14.84 and 12.44 %). The absorption of seed oil extract by the wood samples differ significantly (P≤0.05). Meanwhile, there was no significant differences (p>0.05) in the weight loss due to termite between treated wood samples but untreated wood samples differ significantly (p≤0.05). The M. indica seed extract can serve as an alternative preservative against termite attack thereby reducing environmental pollution that may arise from the use of conventional chemical preservatives.
- Published
- 2021
177. Perceptions of Financial Conflict of Interest and Knowledge of the Sunshine Act Among Orthopedic Surgery Patients
- Author
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Harpal S. Khanuja, Raj M. Amin, John G. Mawn, Joseph Lopez, Julius K. Oni, Jonathan Harrell, Nicholas E. Runge, Robert S. Sterling, and Lauren Hollifield
- Subjects
Finance ,medicine.medical_specialty ,Conflict of Interest ,business.industry ,Compensation (psychology) ,MEDLINE ,Conflict of interest ,Legislation ,Ambivalence ,Orthopedics ,Orthopedic surgery ,Humans ,Medicine ,Orthopedic Procedures ,Perception ,Orthopedics and Sports Medicine ,Surgery ,Prospective Studies ,business ,Surgical Specialty - Abstract
The orthopedic surgical specialty is strongly tied to partnerships with industry that have fostered innovation and greatly enhanced patient care. A substantial number of orthopedic surgeons currently receive some form of industry support. These relationships are highly scrutinized because they present the possibility of both personal and financial conflicts of interest (COI). The authors examined orthopedic patients' awareness of existing regulation and perceptions of financial COI by performing a prospective survey-based study of patients seen in an academic orthopedic department. Data were collected during 1 year, in a cross-section of hospital-based and community clinical settings. The authors collected 513 surveys during a 1-year period between 4 clinical locations. Of all respondents, 55% were unconcerned regarding gifts or direct compensation their physicians received from industry, and only 16% were very or extremely concerned regarding these benefits. Patients' opinions regarding possible influence of benefits were similarly ambivalent, with 54% of patients minimally or not at all concerned regarding the potential influence of industry gifts or compensation. Seventy-six percent of patients had never heard of the Sunshine Act, and only 3% indicated that they were aware of the legislation and its intention. The income of the respondents and their level of education were positively correlated with increased concern about handling of COI, as well as knowledge regarding the Sunshine Act. These data suggest that orthopedic surgery patients are widely unconcerned regarding physician COI, but specific subsets of patients may be more likely to have concerns regarding these relationships. [ Orthopedics . 2021;44(5):e682–e686.]
- Published
- 2021
178. An Analysis of Online Ratings of Pediatric Orthopaedic Surgeons
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Julius K. Oni, Coleen S. Sabatini, Jordan H. Jay, Nicholas E. Runge, and Franz H. Vergara
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Surgeons ,medicine.medical_specialty ,Internet ,business.industry ,Health care provider ,MEDLINE ,General Medicine ,Orthopedic Surgeons ,Osteopathic medicine in the United States ,Subspecialty ,Orthopedics ,Private practice ,Patient Satisfaction ,Family medicine ,Pediatrics, Perinatology and Child Health ,medicine ,Humans ,Orthopedics and Sports Medicine ,Fellowships and Scholarships ,business ,Location ,Child ,Fellowship training ,Medical doctor - Abstract
Background Patients continue to utilize physician review websites (PRWs) to assist in their selection of a health care provider. Studies on PRWs and how they affect patient care have recently become popular in the literature. This study analyzes PRW ratings of a previously unexamined subspecialty, pediatric orthopaedic surgeons. Methods Three hundred ninety-nine randomly selected Pediatric Orthopaedic Society of North America member's PRW ratings were examined from May 4, 2020 to July 18, 2020. Healthgrades.com, Vitals.com, RateMDs.com, and Google.com were reviewed. Number of ratings and average ratings (0 to 5.0) were recorded. Provider sex, years in practice (0 to 10, 11 to 20, and 21+), practice type (academic, private), geographic location (Northeast, Southeast, Midwest, Southwest, West), degree (Medical Doctor, Doctor of Osteopathic Medicine), and fellowship training (yes, no) were recorded. Kruskal-Wallis testing was performed to determine factors affecting positive surgeon ratings. Results 98.5% (393) of Pediatric Orthopaedic Society of North America surgeons were rated on a PRW at least once and were highly rated with an average rating of 4.14 of 5.0. Surgeons in practice 1 to 10 years had higher ratings than those in practice 11 to 20 and 21+ years, on Healthgrades.com (P=0.049) and RateMDs.com (P=0.011). Academic surgeons were found to have higher ratings than those in private practice on Google.com (P=0.007). Sex, region of practice, degree type, and fellowship training status did not have an effect on online ratings across all PRWs. Conclusions Pediatric orthopaedic surgeons are frequently and highly rated, similar to other orthopaedic subspecialties. Surgeons in practice 1 to 10 years were found to have statistically higher ratings on some websites. Academic surgeons were found to have statistically higher ratings on some websites.
- Published
- 2021
179. Chronic Infection Leading to Failure of a Composite Femoral Stem: A Report of Two Cases
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Saltzman, Bryan M., Haughom, Bryan, Oni, Julius K., and Levine, Brett R.
- Published
- 2014
- Full Text
- View/download PDF
180. Effect of incorporation of thermo-regulatory genes into exotic layers on egg production and quality under tropical environment
- Author
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Hagan, Julius K., Adomako, Kwaku, and Olympio, Simon Oscar
- Published
- 2014
- Full Text
- View/download PDF
181. Birth and evolution of a Cryogenian basin: Glaciation, rifting and sedimentation in the Vorogovka Basin, Siberia
- Author
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Sovetov, Julius K. and Le Heron, Daniel P.
- Published
- 2016
- Full Text
- View/download PDF
182. Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions
- Author
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Nina Kunová, Gabriela Ondrovičová, Jacob A. Bauer, Veronika Krajčovičová, Matyáš Pinkas, Barbora Stojkovičová, Henrieta Havalová, Veronika Lukáčová, Lenka Kohútová, Július Košťan, Lucia Martináková, Peter Baráth, Jiří Nováček, Sebastian Zoll, Sami Kereϊche, Eva Kutejová, and Vladimír Pevala
- Subjects
Medicine ,Science - Abstract
Abstract Phosphorylation plays a crucial role in the regulation of many fundamental cellular processes. Phosphorylation levels are increased in many cancer cells where they may promote changes in mitochondrial homeostasis. Proteomic studies on various types of cancer identified 17 phosphorylation sites within the human ATP-dependent protease Lon, which degrades misfolded, unassembled and oxidatively damaged proteins in mitochondria. Most of these sites were found in Lon’s N-terminal (NTD) and ATPase domains, though little is known about the effects on their function. By combining the biochemical and cryo-electron microscopy studies, we show the effect of Tyr186 and Tyr394 phosphorylations in Lon’s NTD, which greatly reduce all Lon activities without affecting its ability to bind substrates or perturbing its tertiary structure. A substantial reduction in Lon’s activities is also observed in the presence of polyphosphate, whose amount significantly increases in cancer cells. Our study thus provides an insight into the possible fine-tuning of Lon activities in human diseases, which highlights Lon’s importance in maintaining proteostasis in mitochondria.
- Published
- 2024
- Full Text
- View/download PDF
183. Growth performance and carcass characteristics of rabbits fed concentrate diets containing graded levels of Brassica oleracea outer leaves and Musa paradisiaca leaves
- Author
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Doris Yaa Osei, Samuel Obeng Apori, Julius Kofi Hagan, David Amedorme, and Raphael Ayizanga
- Subjects
carcass ,forages ,rabbits ,intake ,internal organs ,Animal culture ,SF1-1100 ,Veterinary medicine ,SF600-1100 - Abstract
Ninety-six (96) 8-wk-old “mixed breed” of New Zealand white, California white and chinchilla rabbits were used to determine the growth performance, carcass and organ percentages of rabbits fed concentrate diets containing graded levels of Brassica oleracea outer leaves and Musa paradisiaca leaves. The rabbits were assigned to two groups of 48. Those in group 1 were allotted to four dietary treatments with concentrate diets containing 0, 10, 20 and 30% inclusion levels of B. oleracea outer leaves for one week and 12-wk adaptation and testing periods, respectively, for growth performance evaluation. Similar treatment and design were adopted for group 2 rabbits using graded levels of M. paradisiaca leaves. Six rabbits were randomly selected from each treatment group for slaughter at the end of the testing period for carcass and internal organ characteristics evaluation. There were no dietary effects on the parameters of rabbits fed graded levels of B. oleracea outer leaves except for M. paradisiaca, where the control diet had the lowest feed intake and the least (P
- Published
- 2024
- Full Text
- View/download PDF
184. Compaction and compressibility characteristics of snail shell ash and granulated blast furnace slag stabilized local bentonite for baseliner of landfill
- Author
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Olaolu George Fadugba, Julius Kayode Adeniran, George Uwadiegwu Alaneme, Bamitale Dorcas Oluyemi-Ayibiowu, Oladapo Jayejeje Omomomi, and Adesola Olayinka Adetukasi
- Subjects
Bentonite ,Compaction ,Compressibility ,Landfill liner ,Granulated blast furnace slag ,Snail shell ash ,Medicine ,Science - Abstract
Abstract This study comprehensively explores the compaction and compressibility characteristics of snail shell ash (SSA) and ground-granulated blast-furnace slag (GBFS) in stabilizing local bentonite for landfill baseliner applications. The untreated soil, with a liquid limit of 65%, plastic limit of 35%, and plasticity index of 30%, exhibited optimal compaction at a moisture content of 32% and a maximum dry density of 1423 kg/m3. SSA revealed a dominant presence of 91.551 wt% CaO, while GBFS contained substantial 53.023 wt% SiO2. Treated samples with 20% GBFS and 5% SSA exhibited the highest maximum dry density (1561 kg/m3) and optimal moisture content (13%), surpassing other mixtures. The 15% SSA-treated sample demonstrated superior strength enhancement, reaching an unconfined compressive strength of 272.61 kPa over 28 days, while the 10% GBFS-treated sample achieved 229.95 kPa. The combination of 15% SSA exhibited the highest shear strength (49 kPa) and elastic modulus (142 MPa), showcasing robust mechanical properties. Additionally, the 15% SSA sample displayed favourable hydraulic conductivity (5.57 × 10–8 cm/s), outperforming other mixtures. Notably, the permeability test, a critical aspect of the study, was meticulously conducted in triplicate, ensuring the reliability and reproducibility of the reported hydraulic conductivity values. Treated samples with SSA and GBFS showed reduced compressibility compared to the control soil, with the 15% SSA-treated sample exhibiting a more consistent response to applied pressures. Scanning Electron Microscopy analysis revealed substantial composition changes in the 15% SSA mixture, suggesting its potential as an effective base liner in landfill systems. In conclusion, the 15% SSA sample demonstrated superior mechanical properties and hydraulic conductivity, presenting a promising choice for landfill liner applications.
- Published
- 2024
- Full Text
- View/download PDF
185. Personal Growth and Motto Goals: Strengthening Emotion Regulation Ability via Affirmatory Metaphors Coaching
- Author
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Elena Fischer, Christina Mühlberger, Julia Weber, Eva Jonas, Julius Kuhl, and Markus Quirin
- Subjects
personality growth ,coaching intervention ,emotion regulation ability ,neuroticism ,extraversion ,Psychology ,BF1-990 - Abstract
Interventions can foster personal growth. However, our understanding of the specific mechanisms for change and the types of interventions driving this growth process remains limited. In this study, we focused on emotion regulation ability as a potential mechanism. We examined the effects of an affirmation coaching intervention on changes in emotion regulation ability, an important facet of personality. In this coaching intervention, participants created a personal mantra/goal derived from a selected image and positive associations linked to this image (motto goals). This is considered to enhance emotion regulation abilities by internalizing self-stabilizing value. We assigned sixty-six participants to either this affirmation coaching intervention or one of two control coaching interventions: specific-goal versus indulgence coaching. Before and after each intervention, participants completed questionnaires. Only the affirmation coaching intervention significantly increased in adaptive aspects of personality. Notably, the affirmation coaching intervention increased emotion regulation ability, and this effect persisted even when controlling for extraversion and neuroticism. Furthermore, exploratory analysis showed that extraversion increased following the affirmation coaching, while neuroticism remained unchanged. Our results suggest that emotion regulation ability might be the key factor in personality growth. It could be more malleable and/or respond more strongly to short-term coaching, compared to neuroticism. Thus, the malleability of personality traits may not be an all-or-nothing phenomenon; rather, it could depend on the facet of emotion regulation ability. We discuss potential mechanisms of personality growth, distinguishing between emotion regulation and emotion sensitivity.
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- 2024
- Full Text
- View/download PDF
186. Structure based design, stability study and synthesis of the dinitrophenylhydrazone derivative of the oxidation product of lanosterol as a potential P. falciparum transketolase inhibitor and in-vivo antimalarial study
- Author
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N. O. Omisore, Craig A. Obafemi, Julius K. Adesanwo, Frank A Ogundolie, Oladoja A Awofisayo, Olatomide A. Fadare, and Oluwaseun B. Adegbite
- Subjects
biology ,Stereochemistry ,Lanosterol ,medicine.medical_treatment ,Transketolase ,Cofactor ,Steroid ,chemistry.chemical_compound ,chemistry ,Docking (molecular) ,Automotive Engineering ,biology.protein ,medicine ,Antimalarial Agent ,Derivative (chemistry) ,Thiamine pyrophosphate ,Original Research - Abstract
The growing resistance to the current antimalarial drugs in the absence of a vaccine can be effectively tackled by identifying new metabolic pathways that are essential to the survival of the malaria parasite and developing new drugs against them. Triterpenes and steroids are the most abundant group of natural products with a great variety of biological activities. However, lanosterol is not known to possess any significant biological activity. In this study the binding and interactions of a dinitrophenyl hydrazine (DNP) derivative of lanosterol, LAN (a derivative that incorporates a substantially polar moiety into the steroid) with P. falciparum transketolase was studied by molecular docking and MD simulation with the view to exploit the DNP derivative as a lead in antimalarial chemotherapy development considering that the P. falciparum transketolase (PfTk) is a novel target in antimalarial chemotherapy. The enzyme catalyses the production of ribose sugars needed for nucleic acid synthesis; it lacks a three-dimensional (3D) structure necessary for docking because it is difficult to obtain a crystalline form. A homology model of PfTk was constructed using Saccharomyces cerevisiae transketolase (protein data bank ID of 1TRK) as the template. The compound was observed to have Free Energy of Binding higher than that of the cofactor of the protein (Thiamine Pyrophosphate, TPP) and a synthetic analog (SUBTPP) used as reference compounds after MD Simulation. The compound was synthesized in a two-step, one-pot reaction, utilizing a non-acidic and mild oxidant to oxidize the lanosterol in order to avoid the rearrangement that accompanies the oxidation of sterols using acidic oxidants. The LAN was characterized using IR spectroscopy and NMR experiments and tested in-vivo for its antimalarial chemo suppression using a murine model with Chloroquine as a standard. The LAN at a concentration of 25 mg/kg was found to have a comparable activity with Chloroquine at 10 mg/kg and no mortality was observed among the test animals 24 days post drug administration showing that the compound indeed has potential as an antimalarial agent and a likely inhibitor of PfTk considering that there is a strong agreement between the in-silico results and biological study. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40203-021-00097-8.
- Published
- 2021
187. Historical and contemporary psychotherapy practices in Uganda
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Julius Kikooma, Kizito Wamala, Jane Namusoke, and Joseph Mugarura
- Subjects
Mental healing ,RZ400-408 ,Public aspects of medicine ,RA1-1270 - Published
- 2024
- Full Text
- View/download PDF
188. Stability of Dexamethasone during Hot-Melt Extrusion of Filaments based on Eudragit® RS, Ethyl Cellulose and Polyethylene Oxide
- Author
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Vanessa Domsta, Tessa Boralewski, Martin Ulbricht, Philipp Schick, Julius Krause, and Anne Seidlitz
- Subjects
Hot-melt extrusion ,Eudragit® RS ,Ethyl cellulose ,Polyethylene oxide ,Dexamethasone ,Degradation ,Pharmacy and materia medica ,RS1-441 - Abstract
Hot-melt extrusion (HME) potentially coupled with 3D printing is a promising technique for the manufacturing of dosage forms such as drug-eluting implants which might even be individually adapted to patient-specific anatomy. However, these manufacturing methods involve the risk of thermal degradation of incorporated drugs during processing. In this work, the stability of the anti-inflammatory drug dexamethasone (DEX) was studied during HME using the polymers Eudragit® RS, ethyl cellulose and polyethylene oxide. The extrusion process was performed at different temperatures. Furthermore, the influence of accelerated screw speed, the addition of the plasticizers triethyl citrate and polyethylene glycol 6000 or the addition of the antioxidants butylated hydroxytoluene and tocopherol in two concentrations were studied. The DEX recovery was analyzed by a high performance liquid chromatography method suitable for the detection of thermal degradation products. The strongest impact on the drug stability was found for the processing temperature, which was found to reduce the DEX recovery to
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- 2024
- Full Text
- View/download PDF
189. Predictors and Outcomes of Postoperative Hemoglobin of <8 g/dL in Total Joint Arthroplasty
- Author
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Chaudhry, Yash P., primary, MacMahon, Aoife, additional, Rao, Sandesh S., additional, Mekkawy, Kevin L., additional, Toci, Gregory R., additional, Oni, Julius K., additional, Sterling, Robert S., additional, and Khanuja, Harpal S., additional
- Published
- 2021
- Full Text
- View/download PDF
190. FREE DAY SECONDARY EDUCATION POLICY AND STUDENT ATTENDANCE RATES IN PUBLIC SECONDARY SCHOOLS IN TURKANA COUNTY, KENYA
- Author
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BARASA, MOSES WAFULA, primary, MAIYO, PROF. JULIUS K., additional, and BARASA (PhD), DR. JANE, additional
- Published
- 2021
- Full Text
- View/download PDF
191. Perceptions of Financial Conflict of Interest and Knowledge of the Sunshine Act Among Orthopedic Surgery Patients
- Author
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Mawn, John G., primary, Amin, Raj M., additional, Harrell, Jonathan, additional, Runge, Nicholas, additional, Hollifield, Lauren, additional, Lopez, Joseph, additional, Khanuja, Harpal S., additional, Sterling, Robert S., additional, and Oni, Julius K., additional
- Published
- 2021
- Full Text
- View/download PDF
192. An Analysis of Online Ratings of Pediatric Orthopaedic Surgeons
- Author
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Jay, Jordan H., primary, Runge, Nicholas E., additional, Vergara, Franz H., additional, Sabatini, Coleen S., additional, and Oni, Julius K., additional
- Published
- 2021
- Full Text
- View/download PDF
193. Incidence, mortality, and complications of acute myocardial infarction with and without percutaneous coronary intervention in hip fracture patients
- Author
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Chaudhry, Yash P., primary, MacMahon, Aoife, additional, Rao, Sandesh S., additional, Sterling, Robert S., additional, Oni, Julius K., additional, and Khanuja, Harpal S., additional
- Published
- 2021
- Full Text
- View/download PDF
194. Two Birds, One Stone–An Odd Case of Oligoarthritis
- Author
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I. Lucia Ponor, James S MacKenzie, Julius K. Oni, Oluseye Oduyale, Allison M. Bailey, Martin Auster, and Sara M. Karaba
- Subjects
medicine.medical_specialty ,Oligoarthritis ,Knee Joint ,business.industry ,Radiography ,MEDLINE ,Chondrocalcinosis ,General Medicine ,Osteoarthritis, Knee ,Dermatology ,Diagnosis, Differential ,Synovial Fluid ,Humans ,Medicine ,Female ,business ,Aged - Published
- 2020
195. Identification of Chemical Constituents and Evaluation of the Antibacterial Activity of Methanol Extract and Fractions of the Leaf of Melanthera scandens (Schum. et Thonn.) Roberty
- Author
-
Julius K. Adesanwo, Armando G. McDonald, O.S. Ajayi, Ifeoluwa S. Ajayi, and Oluwatoyin A. Igbeneghu
- Subjects
chemistry.chemical_compound ,Phytomedicine ,biology ,Melanthera scandens ,chemistry ,Traditional medicine ,Chemical constituents ,Biological activity ,Methanol ,Asteraceae ,biology.organism_classification ,Antibacterial activity ,Chemical composition - Abstract
The chemical composition of Melanthera scandens (MS) methanol (MeOH) extract is yet to be fully comprehended. Chemical composition of a plant extract is closely related to the biological activity of the plant material, in phytomedicine. In this study, chemical analyses of MS extracts were carried out with the aim of identifying the organic chemical constituents.
- Published
- 2019
196. Seismic vertical transversely isotropic parameter inversion from P- and S-wave cross-borehole measurements in an aquifer environment
- Author
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Raymond Durrheim, Julius K. von Ketelhodt, Musa Manzi, and Thomas Fechner
- Subjects
geography ,geography.geographical_feature_category ,010504 meteorology & atmospheric sciences ,Lithology ,Borehole ,Inversion (meteorology) ,Aquifer ,Geophysics ,010502 geochemistry & geophysics ,01 natural sciences ,Borehole geophysics ,Geochemistry and Petrology ,Transverse isotropy ,S-wave ,Anisotropy ,Geology ,0105 earth and related environmental sciences - Abstract
Joint P- and S-wave measurements for tomographic cross-borehole analysis can offer more reliable interpretational insight concerning lithologic and geotechnical parameter variations compared with P-wave measurements on their own. However, anisotropy can have a large influence on S-wave measurements, with the S-wave splitting into two modes. We have developed an inversion for parameters of transversely isotropic with a vertical symmetry axis (VTI) media. Our inversion is based on the traveltime perturbation equation, using cross-gradient constraints to ensure structural similarity for the resulting VTI parameters. We first determine the inversion on a synthetic data set consisting of P-waves and vertically and horizontally polarized S-waves. Subsequently, we evaluate inversion results for a data set comprising jointly measured P-waves and vertically and horizontally polarized S-waves that were acquired in a near-surface ([Formula: see text]) aquifer environment (the Safira research site, Germany). The inverted models indicate that the anisotropy parameters [Formula: see text] and [Formula: see text] are close to zero, with no P-wave anisotropy present. A high [Formula: see text] ratio of up to nine causes considerable SV-wave anisotropy despite the low magnitudes for [Formula: see text] and [Formula: see text]. The SH-wave anisotropy parameter [Formula: see text] is estimated to be between 0.05 and 0.15 in the clay and lignite seams. The S-wave splitting is confirmed by polarization analysis prior to the inversion. The results suggest that S-wave anisotropy may be more severe than P-wave anisotropy in near-surface environments and should be taken into account when interpreting cross-borehole S-wave data.
- Published
- 2019
197. Are universal social standards possible?
- Author
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Nyerere, Julius K.
- Published
- 1999
198. JULIUS NYERERE DISCUSSES CRISIS IN SOUTHERN AFRICA
- Author
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Nyerere, Julius K., Clark, Bob, and Matney, Bill
- Published
- 1976
199. From Uhuru to Ujamaa
- Author
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Nyerere, Julius K.
- Published
- 1974
200. Julius K. Nyerere
- Author
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Gauhar, Altaf and Nyerere, Julius K.
- Published
- 1984
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