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787 results on '"Kershaw, Michael"'

152. Dual PD-1 and CTLA-4 Checkpoint Blockade Promotes Antitumor Immune Responses through CD4+Foxp3− Cell–Mediated Modulation of CD103+ Dendritic Cells

Author

Beavis, Paul A., primary, Henderson, Melissa A., additional, Giuffrida, Lauren, additional, Davenport, Alexander J., additional, Petley, Emma V., additional, House, Imran G., additional, Lai, Junyun, additional, Sek, Kevin, additional, Milenkovski, Nicole, additional, John, Liza B., additional, Mardiana, Sherly, additional, Slaney, Clare Y., additional, Trapani, Joseph A., additional, Loi, Sherene, additional, Kershaw, Michael H., additional, Haynes, Nicole M., additional, and Darcy, Phillip K., additional

Published
2018
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154. MoSnt2-dependent deacetylation of histone H3 mediates MoTor-dependent autophagy and plant infection by the rice blast fungus Magnaporthe oryzae

Author

He, Min, primary, Xu, Youpin, additional, Chen, Jinhua, additional, Luo, Yuan, additional, Lv, Yang, additional, Su, Jia, additional, Kershaw, Michael J., additional, Li, Weitao, additional, Wang, Jing, additional, Yin, Junjie, additional, Zhu, Xiaobo, additional, Liu, Xiaohong, additional, Chern, Mawsheng, additional, Ma, Bingtian, additional, Wang, Jichun, additional, Qin, Peng, additional, Chen, Weilan, additional, Wang, Yuping, additional, Wang, Wenming, additional, Ren, Zhenglong, additional, Wu, Xianjun, additional, Li, Ping, additional, Li, Shigui, additional, Peng, Youliang, additional, Lin, Fucheng, additional, Talbot, Nicholas J., additional, and Chen, Xuewei, additional

Published
2018
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158. Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing

Author

Lopez, Jamie A., primary, Noori, Tahereh, additional, Minson, Adrian, additional, Li Jovanoska, Lu, additional, Thia, Kevin, additional, Hildebrand, Michael S., additional, Akhlaghi, Hedieh, additional, Darcy, Phillip K., additional, Kershaw, Michael H., additional, Brown, Natasha J., additional, Grigg, Andrew, additional, Trapani, Joseph A., additional, and Voskoboinik, Ilia, additional

Published
2018
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160. An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy

Author

Westwood, Jennifer A., primary, Ellis, Sarah, additional, Danne, Jill, additional, Johnson, Chad, additional, Oorschot, Viola, additional, Ramm, Georg, additional, Tscharke, David C., additional, Davenport, Alexander J., additional, Whisstock, James C., additional, Darcy, Phillip K., additional, Kershaw, Michael H., additional, and Slaney, Clare Y., additional

Published
2017
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162. Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

Author

Dushyanthen, Sathana, Kershaw, Michael M.H., Trapani, Joseph J.A., Neeson, Paul P.J., Salgado, Roberto, McArthur, Grant A, Balko, Justin J.M., Beavis, Paul P.A., Darcy, Phillip K, Loi, Sherene, Teo, Zhi Ling, Caramia, Franco, Savas, Peter, Mintoff, Christopher Paul, Virassamy, Balaji, Henderson, Melissa M.A., Luen, Stephen, Mansour, Mariam, Dushyanthen, Sathana, Kershaw, Michael M.H., Trapani, Joseph J.A., Neeson, Paul P.J., Salgado, Roberto, McArthur, Grant A, Balko, Justin J.M., Beavis, Paul P.A., Darcy, Phillip K, Loi, Sherene, Teo, Zhi Ling, Caramia, Franco, Savas, Peter, Mintoff, Christopher Paul, Virassamy, Balaji, Henderson, Melissa M.A., Luen, Stephen, and Mansour, Mariam

Abstract

The presence of tumor-infiltrating lymphocytes in triple-negative breast cancers is correlated with improved outcomes. Ras/MAPK pathway activation is associated with significantly lower levels of tumor-infiltrating lymphocytes in triple-negative breast cancers and while MEK inhibition can promote recruitment of tumor-infiltrating lymphocytes to the tumor, here we show that MEK inhibition adversely affects early onset T-cell effector function. We show that α-4-1BB and α-OX-40 T-cell agonist antibodies can rescue the adverse effects of MEK inhibition on T cells in both mouse and human T cells, which results in augmented anti-tumor effects in vivo. This effect is dependent upon increased downstream p38/JNK pathway activation. Taken together, our data suggest that although Ras/MAPK pathway inhibition can increase tumor immunogenicity, the negative impact on T-cell activity is functionally important. This undesirable impact is effectively prevented by combination with T-cell immune agonist immunotherapies resulting in superior therapeutic efficacy., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2017

163. A multifunctional role for adjuvant Anti-4-1BB therapy in augmenting antitumor response by chimeric antigen receptor T cells

Author

Mardiana, Sherly, John, Liza B., Henderson, Melissa A., Slaney, Clare Y., von Scheidt, Bianca, Giuffrida, Lauren, Davenport, Alexander J., Trapani, Joseph A., Neeson, Paul J., Loi, Sherene, Haynes, Nicole M., Kershaw, Michael H., Beavis, Paul A., Darcy, Phillip K., Mardiana, Sherly, John, Liza B., Henderson, Melissa A., Slaney, Clare Y., von Scheidt, Bianca, Giuffrida, Lauren, Davenport, Alexander J., Trapani, Joseph A., Neeson, Paul J., Loi, Sherene, Haynes, Nicole M., Kershaw, Michael H., Beavis, Paul A., and Darcy, Phillip K.

Published
2017

165. Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

Author

Dushyanthen, Sathana, primary, Teo, Zhi Ling, additional, Caramia, Franco, additional, Savas, Peter, additional, Mintoff, Christopher P., additional, Virassamy, Balaji, additional, Henderson, Melissa A., additional, Luen, Stephen J., additional, Mansour, Mariam, additional, Kershaw, Michael H., additional, Trapani, Joseph A., additional, Neeson, Paul J., additional, Salgado, Roberto, additional, McArthur, Grant A., additional, Balko, Justin M., additional, Beavis, Paul A., additional, Darcy, Phillip K., additional, and Loi, Sherene, additional

Published
2017
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167. Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Author

Slaney, Clare Y., primary, von Scheidt, Bianca, additional, Davenport, Alexander J., additional, Beavis, Paul A., additional, Westwood, Jennifer A., additional, Mardiana, Sherly, additional, Tscharke, David C., additional, Ellis, Sarah, additional, Prince, H. Miles, additional, Trapani, Joseph A., additional, Johnstone, Ricky W., additional, Smyth, Mark J., additional, Teng, Michele W., additional, Ali, Aesha, additional, Yu, Zhiya, additional, Rosenberg, Steven A., additional, Restifo, Nicholas P., additional, Neeson, Paul, additional, Darcy, Phillip K., additional, and Kershaw, Michael H., additional

Published
2017
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168. A Multifunctional Role for Adjuvant Anti-4-1BB Therapy in Augmenting Antitumor Response by Chimeric Antigen Receptor T Cells

Author

Mardiana, Sherly, primary, John, Liza B., additional, Henderson, Melissa A., additional, Slaney, Clare Y., additional, von Scheidt, Bianca, additional, Giuffrida, Lauren, additional, Davenport, Alexander J., additional, Trapani, Joseph A., additional, Neeson, Paul J., additional, Loi, Sherene, additional, Haynes, Nicole M., additional, Kershaw, Michael H., additional, Beavis, Paul A., additional, and Darcy, Phillip K., additional

Published
2017
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170. CAR T‐cell therapy of solid tumors

Author

Yong, Carmen S M, primary, Dardalhon, Valerie, additional, Devaud, Christel, additional, Taylor, Naomi, additional, Darcy, Phillip K, additional, and Kershaw, Michael H, additional

Published
2017
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173. Cross-talk between tumors can affect responses to therapy

Author

Devaud, Christel, John, Liza B, Westwood, Jennifer A, Yong, Carmen S M, Beavis, Paul A, Schwendener, Reto A, Darcy, Phillip K, Kershaw, Michael H, University of Zurich, and Devaud, Christel

Subjects
2403 Immunology, 10061 Institute of Molecular Cancer Research, 2723 Immunology and Allergy, 570 Life sciences, biology, 610 Medicine & health, 2730 Oncology
Published
2015

174. Conidial Morphogenesis and Septin-Mediated Plant Infection Require Smo1, a Ras GTPase-Activating Protein in Magnaporthe oryzae.

Author

Kershaw, Michael J., Basiewicz, Magdalena, Soanes, Darren M., Xia Yan, Ryder, Lauren S., Csukai, Michael, Oses-Ruiz, Miriam, Valent, Barbara, and Talbot, Nicholas J.

Subjects
*CARRIER proteins, *CELLULAR signal transduction, *CYTOPLASM, *FUNGI, *GENETICS, *GENOMES, *MORPHOGENESIS, *MUSCLE proteins, *GENETIC mutation, *PLANT diseases, *PLANTS, *PROTEINS, *RICE
Abstract

The pathogenic life cycle of the rice blast fungus Magnaporthe oryzae involves a series of morphogenetic changes, essential for its ability to cause disease. The smo mutation was identified. 25 years ago, and affects the shape and development of diverse cell types in M. oryzae, including conidia, appressoria, and asci. All attempts to clone the SMO1 gene by map-based cloning or complementation have failed over many years. Here, we report the identification of SMO1 by a combination of bulk segregant analysis and comparative genome analysis. SMO1 encodes a GTPase-activating protein, which regulates Ras signaling during infectionrelated development. Targeted deletion of SMO1 results in abnormal, nonadherent conidia, impaired in their production of spore tip mucilage. Smo1 mutants also develop smaller appressoria, with a severely reduced capacity to infect rice plants. SMO1 is necessary for the organization of microtubules and for septin-dependent remodeling of the F-actin cytoskeleton at the appressorium pore. Smo1 physically interacts with components of the Ras2 signaling complex, and a range of other signaling and cytoskeletal components, including the four core septins. SMO1 is therefore necessary for the regulation of RAS activation required for conidial morphogenesis and septin-mediated plant infection. [ABSTRACT FROM AUTHOR]

Published
2019
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176. Frustration and Force Majeure.

Author

Kershaw, Michael

Subjects
Frustration and Force Majeure (Book) -- Book reviews, Books -- Book reviews
Published
1995

185. CAR-T Cells Are Serial Killers of Tumor Cells

Author

Jenkins, Misty, primary, Davenport, Alex, additional, Cross, Ryan, additional, Yong, Carmen, additional, Ritchie, David S., additional, Trapani, Joe, additional, Kershaw, Michael, additional, Darcy, Phil, additional, and Neeson, Paul, additional

Published
2015
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187. A sensor kinase controls turgor-driven plant infection by the rice blast fungus

Author

Ryder, Lauren S., Dagdas, Yasin F., Kershaw, Michael J., Venkataraman, Chandrasekhar, Madzvamuse, Anotida, Yan, Xia, Cruz-Mireles, Neftaly, Soanes, Darren M., Oses-Ruiz, Miriam, Styles, Vanessa, Sklenar, Jan, Menke, Frank L. H., and Talbot, Nicholas J.

Abstract

The blast fungus Magnaporthe oryzaegains entry to its host plant by means of a specialized pressure-generating infection cell called an appressorium, which physically ruptures the leaf cuticle1,2. Turgor is applied as an enormous invasive force by septin-mediated reorganization of the cytoskeleton and actin-dependent protrusion of a rigid penetration hypha3. However, the molecular mechanisms that regulate the generation of turgor pressure during appressorium-mediated infection of plants remain poorly understood. Here we show that a turgor-sensing histidine–aspartate kinase, Sln1, enables the appressorium to sense when a critical turgor threshold has been reached and thereby facilitates host penetration. We found that the Sln1 sensor localizes to the appressorium pore in a pressure-dependent manner, which is consistent with the predictions of a mathematical model for plant infection. A Δsln1mutant generates excess intracellular appressorium turgor, produces hyper-melanized non-functional appressoria and does not organize the septins and polarity determinants that are required for leaf infection. Sln1 acts in parallel with the protein kinase C cell-integrity pathway as a regulator of cAMP-dependent signalling by protein kinase A. Pkc1 phosphorylates the NADPH oxidase regulator NoxR and, collectively, these signalling pathways modulate appressorium turgor and trigger the generation of invasive force to cause blast disease.

Published
2019
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188. Opening the gateway to tumors

Author

Kershaw, Michael H

Abstract

Author(s): Michael H Kershaw [1] Why does the immune system help thwart tumor growth in some people with cancer but not in others? The work of Buckanvich et al. [1] [...]

Published
2008
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190. Abstract B10: Individual CAR-T cells, when activated via their CAR or TCR, kill tumor cells with similar kinetics and can kill multiple sequential tumor targets

Author

Davenport, Alex J., primary, Jenkins, Misty R., additional, Cross, Ryan S., additional, Carmen, S Yong, additional, Prince, H Miles, additional, Ritchie, David S., additional, Trapani, Joseph A., additional, Kershaw, Michael H., additional, Darcy, Phillip K., additional, and Neeson, Paul J., additional

Published
2015
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191. Embryonic Lethality in Homozygous Human Her-2 Transgenic Mice Due to Disruption of the Pds5b Gene

Author

Yong, Carmen S. M., primary, Sharkey, Janelle, additional, Duscio, Belinda, additional, Venville, Ben, additional, Wei, Wei-Zen, additional, Jones, Richard F., additional, Slaney, Clare Y., additional, Mir Arnau, Gisela, additional, Papenfuss, Anthony T., additional, Schröder, Jan, additional, Darcy, Phillip K., additional, and Kershaw, Michael H., additional

Published
2015
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193. CAR-T cells are serial killers

Author

Davenport, Alexander J, primary, Jenkins, Misty R, additional, Ritchie, David S, additional, Prince, H Miles, additional, Trapani, Joseph A, additional, Kershaw, Michael H, additional, Darcy, Phillip K, additional, and Neeson, Paul J, additional

Published
2015
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194. CD73: A potential biomarker for anti-PD-1 therapy

Author

Beavis, Paul A, primary, Slaney, Clare Y, additional, Milenkovski, Nicole, additional, Henderson, Melissa A, additional, Loi, Sherene, additional, Stagg, John, additional, Kershaw, Michael H, additional, and Darcy, Phillip K, additional

Published
2015
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195. CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells

Author

Davenport, Alexander J., primary, Jenkins, Misty R., additional, Cross, Ryan S., additional, Yong, Carmen S., additional, Prince, H. Miles, additional, Ritchie, David S., additional, Trapani, Joseph A., additional, Kershaw, Michael H., additional, Darcy, Phillip K., additional, and Neeson, Paul J., additional

Published
2015
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197. Foxp3 expression in macrophages associated with RENCA tumors in mice.

Author

Devaud, Christel, Yong, Carmen SM, John, Liza B, Westwood, Jennifer A, Duong, Connie PM, House, Colin M, Denoyer, Delphine, Li, Jason, Darcy, Phillip K, Kershaw, Michael H, Devaud, Christel, Yong, Carmen SM, John, Liza B, Westwood, Jennifer A, Duong, Connie PM, House, Colin M, Denoyer, Delphine, Li, Jason, Darcy, Phillip K, and Kershaw, Michael H

Abstract

The transcription factor Foxp3 represents the most specific functional marker of CD4+ regulatory T cells (TRegs). However, previous reports have described Foxp3 expression in other cell types including some subsets of macrophages, although there are conflicting reports and Foxp3 expression in cells other than Treg is not well characterized. We performed detailed investigations into Foxp3 expression in macrophages in the normal tissue and tumor settings. We detected Foxp3 protein in macrophages infiltrating mouse renal cancer tumors injected subcutaneously or in the kidney. Expression was demonstrated using flow cytometry and Western blot with two individual monoclonal antibodies. Further analyses confirmed Foxp3 expression in macrophages by RT PCR, and studies using ribonucleic acid-sequencing (RNAseq) demonstrated a previously unknown Foxp3 messenger (m)RNA transcript in tumor-associated macrophages. In addition, depletion of Foxp3+ cells using diphtheria toxin in Foxp3DTR mice reduced the frequency of type-2 macrophages (M2) in kidney tumors. Collectively, these results indicate that tumor-associated macrophages could express Foxp3.

Published
2014

200. Genetic regulation of the response to Her-2 DNA vaccination in human Her-2 transgenic mice 1

Author

Radkevich-Brown, Olga, Jacob, Jennifer, Kershaw, Michael, and Wei, Wei-Zen

Subjects
Mice, Inbred BALB C, Receptor, ErbB-2, T-Lymphocytes, Interleukin-2 Receptor alpha Subunit, Antibodies, Monoclonal, Mammary Neoplasms, Animal, Mice, Transgenic, Lymphocyte Activation, Cancer Vaccines, T-Lymphocytes, Regulatory, Article, Mice, Inbred C57BL, Mice, Cell Line, Tumor, Vaccines, DNA, Animals, Humans, Female
Abstract

Genetic regulation of immune reactivity to Her-2 vaccination and the consequent antitumor effect was tested in human Her-2 transgenic (Tg) mice of C57BL/6 (B6), BALB/c (BALB), and (B6x BALB) F1 (F1) background. Mice were electrovaccinated with Her-2 DNA with or without pretreatment with CD25 monoclonal antibody to remove CD25(hi) regulatory T cells. When CD25(+) T cells were intact, BALB Her-2 Tg mice were more responsive than the other two strains in both humoral and cellular immunities, and their tumor growth was significantly delayed. B6 Her-2 Tg mice responded poorly and F1 mice showed modest immune reactivity, but tumor growth did not change in either strain. Depletion of CD25(hi) T cells before vaccination significantly improved protection from tumor challenge in F1 Her-2 Tg mice. This was associated with elevated levels of Her-2 IgG1, IgG2a, and IgG2c antibodies, and some mice also showed IFN-gamma producing T-cell response. The same treatment induced modest improvement in B6 Her-2 Tg mice. In BALB Her-2 Tg mice, however, depletion of CD25(hi) T cells did not further improve antitumor efficacy. Although their Her-2-specific IgG1 and interleukin-5-secreting T cells increased, the levels of IgG2a and IFN-gamma-secreting T cells did not change. These results are the first to show genetic regulation of the response to a cancer vaccine and an unequal effect of removing CD25(hi) T cells on antitumor immunity. These results warrant individualized treatment plans for patients with heterogeneous genetic backgrounds and possibly differential intrinsic immune reactivity to tumor antigens.

Published
2009

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