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2,188 results on '"Klein, Stefan"'

151. The Controversial Definition of Normal Toe Alignment

Author

Schippers, Philipp, primary, Drees, Philipp, additional, Gercek, Erol, additional, Wunderlich, Felix, additional, Müller, Daniel, additional, Ruckes, Christian, additional, Meyer, Alexander, additional, Klein, Stefan, additional, and Fischer, Sebastian, additional

Published
2023
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152. Performing Research Validity: A 'Mangle of Practice' Approach

Author

Johnston, Robert B., Reimers, Kai, Klein, Stefan, Rannenberg, Kai, Editor-in-chief, Sakarovitch, Jacques, Series editor, Goedicke, Michael, Series editor, Tatnall, Arthur, Series editor, Neuhold, Erich J., Series editor, Pras, Aiko, Series editor, Tröltzsch, Fredi, Series editor, Pries-Heje, Jan, Series editor, Whitehouse, Diane, Series editor, Reis, Ricardo, Series editor, Furnell, Steven, Series editor, Furbach, Ulrich, Series editor, Gulliksen, Jan, Series editor, Rauterberg, Matthias, Series editor, Introna, Lucas, editor, Kavanagh, Donncha, editor, Kelly, Séamas, editor, Orlikowski, Wanda, editor, and Scott, Susan, editor

Published
2016
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153. Evaluating the Predictive Value of Glioma Growth Models for Low-Grade Glioma After Tumor Resection

Author

van Garderen, Karin A., van der Voort, Sebastian R., Wijnenga, Maarten M. J., Incekara, Fatih, Alafandi, Ahmad, Kapsas, Georgios, Gahrmann, Renske, Schouten, Joost W., Dubbink, Hendrikus J., Vincent, Arnaud J. P. E., van den Bent, Martin, French, Pim J., Smits, Marion, and Klein, Stefan

Abstract

Tumor growth models have the potential to model and predict the spatiotemporal evolution of glioma in individual patients. Infiltration of glioma cells is known to be faster along the white matter tracts, and therefore structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) can be used to inform the model. However, applying and evaluating growth models in real patient data is challenging. In this work, we propose to formulate the problem of tumor growth as a ranking problem, as opposed to a segmentation problem, and use the average precision (AP) as a performance metric. This enables an evaluation of the spatial pattern that does not require a volume cut-off value. Using the AP metric, we evaluate diffusion-proliferation models informed by structural MRI and DTI, after tumor resection. We applied the models to a unique longitudinal dataset of 14 patients with low-grade glioma (LGG), who received no treatment after surgical resection, to predict the recurrent tumor shape after tumor resection. The diffusion models informed by structural MRI and DTI showed a small but significant increase in predictive performance with respect to homogeneous isotropic diffusion, and the DTI-informed model reached the best predictive performance. We conclude there is a significant improvement in the prediction of the recurrent tumor shape when using a DTI-informed anisotropic diffusion model with respect to istropic diffusion, and that the AP is a suitable metric to evaluate these models. All code and data used in this publication are made publicly available.

Published
2024
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154. Long-Term Follow-Up and Impact of Comorbidity before Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Relapsed or Refractory Acute Myeloid Leukemia—Lessons Learned from the Prospective BRIDGE Trial

Author

Middeke, Jan Moritz, Herbst, Regina, Parmentier, Stefani, Bug, Gesine, Hänel, Mathias, Stuhler, Gernot, Schäfer-Eckart, Kerstin, Rösler, Wolf, Klein, Stefan, Bethge, Wolfgang, Bitz, Ulrich, Büttner, Bozena, Knoth, Holger, Alakel, Nael, Schaich, Markus, Morgner, Anke, Kramer, Michael, Sockel, Katja, von Bonin, Malte, Stölzel, Friedrich, Platzbecker, Uwe, Röllig, Christoph, Thiede, Christian, Ehninger, Gerhard, Bornhäuser, Martin, and Schetelig, Johannes

Published
2017
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162. Matching for the MICA-129 polymorphism is beneficial in unrelated hematopoietic stem cell transplantation

Author

Fuerst, Daniel, Neuchel, Christine, Niederwieser, Dietger, Bunjes, Donald, Gramatzki, Martin, Wagner, Eva, Wulf, Gerald, Glass, Bertram, Pfreundschuh, Michael, Einsele, Hermann, Arnold, Renate, Stuhler, Gernot, Schaefer-Eckart, Kerstin, Freitag, Sebastian, Casper, Jochen, Kaufmann, Martin, Wattad, Mohammed, Hertenstein, Bernd, Klein, Stefan, Ringhoffer, Mark, Mytilineos, Daphne, Tsamadou, Chrysanthi, Mueller, Carlheinz, Schrezenmeier, Hubert, and Mytilineos, Joannis

Published
2016
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166. Venetoclax-Based Salvage Therapy Improves Outcome in Relapsed/Refractory AML Patients Eligible for Intensive Treatment: A Propensity Score Matching Analysis

Author

Unglaub, Julia N., Schlenk, Richard F., Hanoun, Maher, Reinhardt, H. Christian, Middeke, Jan Moritz, Schäfer-Eckart, Kerstin, Steffen, Björn, Krause, Stefan W., Schliemann, Christoph, Kaufmann, Martin, Hänel, Mathias, Jost, Edgar, Crysandt, Martina, Fransecky, Lars, Einsele, Hermann, Kraus, Sabrina, Niemann, Dirk, Neubauer, Andreas, Seggewiss-Bernhardt, Ruth, Scholl, Sebastian, Klein, Stefan, Schmid, Christoph, Schaich, Markus, Platzbecker, Uwe, Baldus, Claudia D., Bornhäuser, Martin, Serve, Hubert, Röllig, Christoph, Kramer, Michael, Katelari, Elena, Janssen, Maike, Pabst, Caroline, Luft, Thomas, Dreger, Peter, Müller-Tidow, Carsten, and Sauer, Tim

Subjects
Immunology, ddc:610, Cell Biology, Hematology, Biochemistry
Published
2022

168. Appendix 2 from Predicting the 1p/19q Codeletion Status of Presumed Low-Grade Glioma with an Externally Validated Machine Learning Algorithm

Author

van der Voort, Sebastian R., primary, Incekara, Fatih, primary, Wijnenga, Maarten M.J., primary, Kapas, Georgios, primary, Gardeniers, Mayke, primary, Schouten, Joost W., primary, Starmans, Martijn P.A., primary, Nandoe Tewarie, Rishie, primary, Lycklama, Geert J., primary, French, Pim J., primary, Dubbink, Hendrikus J., primary, van den Bent, Martin J., primary, Vincent, Arnaud J.P.E., primary, Niessen, Wiro J., primary, Klein, Stefan, primary, and Smits, Marion, primary

Published
2023
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169. Online Figure 1 from Predicting the 1p/19q Codeletion Status of Presumed Low-Grade Glioma with an Externally Validated Machine Learning Algorithm

Author

van der Voort, Sebastian R., primary, Incekara, Fatih, primary, Wijnenga, Maarten M.J., primary, Kapas, Georgios, primary, Gardeniers, Mayke, primary, Schouten, Joost W., primary, Starmans, Martijn P.A., primary, Nandoe Tewarie, Rishie, primary, Lycklama, Geert J., primary, French, Pim J., primary, Dubbink, Hendrikus J., primary, van den Bent, Martin J., primary, Vincent, Arnaud J.P.E., primary, Niessen, Wiro J., primary, Klein, Stefan, primary, and Smits, Marion, primary

Published
2023
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170. Online Figure 2 from Predicting the 1p/19q Codeletion Status of Presumed Low-Grade Glioma with an Externally Validated Machine Learning Algorithm

Author

van der Voort, Sebastian R., primary, Incekara, Fatih, primary, Wijnenga, Maarten M.J., primary, Kapas, Georgios, primary, Gardeniers, Mayke, primary, Schouten, Joost W., primary, Starmans, Martijn P.A., primary, Nandoe Tewarie, Rishie, primary, Lycklama, Geert J., primary, French, Pim J., primary, Dubbink, Hendrikus J., primary, van den Bent, Martin J., primary, Vincent, Arnaud J.P.E., primary, Niessen, Wiro J., primary, Klein, Stefan, primary, and Smits, Marion, primary

Published
2023
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171. Appendix 4 from Predicting the 1p/19q Codeletion Status of Presumed Low-Grade Glioma with an Externally Validated Machine Learning Algorithm

Author

van der Voort, Sebastian R., primary, Incekara, Fatih, primary, Wijnenga, Maarten M.J., primary, Kapas, Georgios, primary, Gardeniers, Mayke, primary, Schouten, Joost W., primary, Starmans, Martijn P.A., primary, Nandoe Tewarie, Rishie, primary, Lycklama, Geert J., primary, French, Pim J., primary, Dubbink, Hendrikus J., primary, van den Bent, Martin J., primary, Vincent, Arnaud J.P.E., primary, Niessen, Wiro J., primary, Klein, Stefan, primary, and Smits, Marion, primary

Published
2023
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172. The effect of a combined indomethacin and levonorgestrel-releasing intrauterine system on short-term postplacement bleeding profile: a randomized proof-of-concept trial

Author

Fels, Lueder M., primary, Costescu, Dustin, additional, Vieira, Carolina S., additional, Peipert, Jeffrey F., additional, Lukkari-Lax, Eeva, additional, Hofmann, Birte M., additional, Reinecke, Isabel, additional, Klein, Stefan, additional, Wiesinger, Katrin, additional, Lindenthal, Bernhard, additional, and Speer, Runa, additional

Published
2023
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174. Allogeneic Hematopoietic Cell Transplantation vs Standard Consolidation Chemotherapy in Patients With Intermediate-Risk Acute Myeloid Leukemia

Author

Bornhäuser, Martin, primary, Schliemann, Christoph, additional, Schetelig, Johannes, additional, Röllig, Christoph, additional, Kramer, Michael, additional, Glass, Bertram, additional, Platzbecker, Uwe, additional, Burchert, Andreas, additional, Hänel, Mathias, additional, Müller, Lutz P., additional, Klein, Stefan, additional, Bug, Gesine, additional, Beelen, Dietrich, additional, Rösler, Wolf, additional, Schäfer-Eckart, Kerstin, additional, Schmid, Christoph, additional, Jost, Edgar, additional, Lenz, Georg, additional, Tischer, Johanna, additional, Spiekermann, Karsten, additional, Pfirrmann, Markus, additional, Serve, Hubert, additional, Stölzel, Friedrich, additional, Alakel, Nael, additional, Middeke, Jan Moritz, additional, Thiede, Christian, additional, Ehninger, Gerhard, additional, Berdel, Wolfgang E., additional, and Stelljes, Matthias, additional

Published
2023
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175. A discriminative event‐based model for subtype diagnosis of sporadic Creutzfeldt‐Jakob disease using brain MRI

Author

Venkatraghavan, Vikram, primary, Pascuzzo, Riccardo, additional, Bron, Esther E., additional, Moscatelli, Marco, additional, Grisoli, Marina, additional, Pickens, Amy, additional, Cohen, Mark L., additional, Schonberger, Lawrence B., additional, Gambetti, Pierluigi, additional, Appleby, Brian S., additional, Klein, Stefan, additional, and Bizzi, Alberto, additional

Published
2023
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176. Treatment of relapsed AML and MDS after allogeneic stem cell transplantation with decitabine and DLI—a retrospective multicenter analysis on behalf of the German Cooperative Transplant Study Group

Author

Schroeder, Thomas, Rautenberg, Christina, Krüger, William, Platzbecker, Uwe, Bug, Gesine, Steinmann, Juliane, Klein, Stefan, Hopfer, Olaf, Nachtkamp, Kathrin, Kondakci, Mustafa, Geyh, Stefanie, Haas, Rainer, Germing, Ulrich, Bornhäuser, Martin, and Kobbe, Guido

Published
2017
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177. itk-elastix: Medical image registration in Python

Author

Ntatsis, Konstantinos, primary, Dekker, Niels, additional, van der Valk, Viktor, additional, Birdsong, Tom, additional, Zukić, Dženan, additional, Klein, Stefan, additional, Staring, Marius, additional, and McCormick, Matthew, additional

Published
2023
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178. Flow Cytometric Characterization of Hematopoietic Stem and Progenitor Cell Subpopulations in Autologous Peripheral Blood Stem Cell Preparations after Cryopreservation

Author

Heuer, Anabel, primary, Löwhagen, Svea, additional, Uhlig, Stefanie, additional, Hetjens, Svetlana, additional, Büttner, Sylvia, additional, Pflästerer, Britta, additional, Diehlmann, Anke, additional, Klein, Stefan, additional, Klüter, Harald, additional, Bieback, Karen, additional, and Wuchter, Patrick, additional

Published
2023
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179. Evaluating the predictive value of glioma growth models for low-grade glioma after tumor resection

Author

van Garderen, Karin A., primary, van der Voort, Sebastian R., additional, Wijnenga, Maarten M.J., additional, Incekara, Fatih, additional, Alafandi, Ahmad, additional, Kapsas, Georgios, additional, Gahrmann, Renske, additional, Schouten, Joost W., additional, Dubbink, Hendrikus J., additional, Vincent, Arnaud J.P.E., additional, van den Bent, Martin, additional, French, Pim J., additional, Smits, Marion, additional, and Klein, Stefan, additional

Published
2023
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180. Conclusions

Author

Tan, Yao-Hua, Bjorn-Andersen, Niels, Klein, Stefan, Rukanova, Boriana, van Ipenburg, Fred, Smit, Godfried, Tan, Yao-Hua, editor, Björn-Andersen, Niels, editor, Klein, Stefan, editor, and Rukanova, Boriana, editor

Published
2011
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182. Network Collaboration Models

Author

Klein, Stefan, Higgins, Allen, Rukanova, Boriana, Tan, Yao-Hua, editor, Björn-Andersen, Niels, editor, Klein, Stefan, editor, and Rukanova, Boriana, editor

Published
2011
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185. Introduction

Author

Rukanova, Boriana, Björn-Andersen, Niels, Ipenburg, Fred van, Klein, Stefan, Smit, Godfried, Tan, Yao-Hua, Tan, Yao-Hua, editor, Björn-Andersen, Niels, editor, Klein, Stefan, editor, and Rukanova, Boriana, editor

Published
2011
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187. Additional file 3 of The P2X3 receptor antagonist filapixant in patients with refractory chronic cough: a randomized controlled trial

Author

Friedrich, Christian, Francke, Klaus, Birring, Surinder S., van den Berg, Jan Willem K., Marsden, Paul A., McGarvey, Lorcan, Turner, Alice M., Wielders, Pascal, Gashaw, Isabella, Klein, Stefan, and Morice, Alyn H.

Abstract

Additional file 3: Table S1. 24-h cough monitoring: Cough count [1/hour]. Table S2. 24-h cough frequency: Subgroup analyses by baseline cough count (Bayesian mixed model). Table S3. 24-h cough frequency: Responder rates for different change thresholds. Table S4. VAS cough severity: Responder rates. Table S5. Treatment-emergent adverse events observed in > 5% of patients. Table S6. Cough frequency: Subgroup analyses by occurrence of taste-related adverse events (Bayesian mixed model). Table S7. Cough severity (VAS): Subgroup analyses by occurrence of taste-related adverse events (Bayesian mixed model). Figure S1. Plasma concentration–time curves for filapixant after multiple administrations.

Published
2023
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189. Allogeneic Hematopoietic Cell Transplantation vs Standard Consolidation Chemotherapy in Patients with Intermediate-Risk Acute Myeloid Leukemia : A Randomized Clinical Trial

Author

Bornhäuser, Martin, Schliemann, Christoph, Schetelig, Johannes, Röllig, Christoph, Kramer, Michael, Glass, Bertram, Platzbecker, Uwe, Burchert, Andreas, Hänel, Mathias, Müller, Lutz P., Klein, Stefan, Bug, Gesine, Beelen, Dietrich, Rösler, Wolf, Schäfer-Eckart, Kerstin, Schmid, Christoph, Jost, Edgar, Lenz, Georg, Tischer, Johanna, Spiekermann, Karsten, Pfirrmann, Markus, Serve, Hubert, Stölzel, Friedrich, Alakel, Nael, Middeke, Jan Moritz, Thiede, Christian, Ehninger, Gerhard, Berdel, Wolfgang E., and Stelljes, Matthias

Subjects
Cancer Research, Oncology, Medizin
Abstract

ImportanceThe ideal postremission strategy in intermediate-risk acute myeloid leukemia (AML) in first complete remission (CR) has been a matter of debate.ObjectiveTo explore the optimal therapy for patients with intermediate-risk AML after first complete remission.Design, Settings, and ParticipantsThis investigator-initiated, open-label, 2-armed, phase 3 randomized clinical trial assessed patients at 16 hospitals in Germany from February 2, 2011, until July 1, 2018. Key eligibility criteria included cytogenetically defined intermediate-risk AML according to Medical Research Council classification, first CR or CR with incomplete blood cell count recovery after conventional induction therapy, age of 18 to 60 years, and availability of a human leukocyte antigen (HLA)–matched sibling or unrelated donor. A detailed statistical analysis plan was written and finalized on July 7, 2020. Data were exported for analysis on April 13, 2021.InterventionsPatients were randomized 1:1 to receive allogeneic hematopoietic cell transplantation (HCT) or high-dose cytarabine for consolidation and salvage HCT only in case of relapse. Strata for randomization included age (18-40 vs 41-60 years), NPM1 and CEBPA variation status, and donor type (unrelated vs related).Main Outcomes and MeasuresEnd points included overall-survival as the primary outcome and disease-free survival, cumulative incidence of relapse, treatment-related mortality, and quality of life measured according to the Medical Outcomes Study 36-Item Short-Form Health Survey as secondary outcomes.ResultsA total of 143 patients (mean [SD] age, 48.2 [9.8] years; 81 [57%] male) with AML who fulfilled the eligibility criteria were randomized. In the intention-to-treat analysis, the probability of survival at 2 years was 74% (95% CI, 62%-83%) after primary allogeneic HCT and 84% (95% CI, 73%-92%) after consolidation chemotherapy (P = .22). Disease-free survival after HCT at 2 years was 69% (95% CI, 57%-80%) compared with 40% (95% CI, 28%-53%) after consolidation chemotherapy (P = .001). Allogeneic HCT during the first CR was associated with a cumulative incidence of relapse at 2 years of 20% (95% CI, 13%-31%) compared with 58% (95% CI, 47%-71%; P P = .005). Similar outcomes were observed when analyses were confined to the 96 patients at intermediate risk according to the European Leukemia Network classification. Most importantly, all 41 patients relapsing after consolidation chemotherapy (36 hematologic, 4 molecular, and 1 extramedullary) proceeded to allogeneic HCT. No significant differences in health-related quality of life measures were observed between groups.Conclusions and RelevancePrimary allogeneic HCT during first CR was not associated with superior overall survival compared with consolidation chemotherapy in patients 60 years or younger with intermediate-risk AML during the first CR and an available donor.Trial RegistrationClinicalTrials.gov Identifier: NCT01246752

Published
2023

192. Feature Selection Based on SVM Significance Maps for Classification of Dementia

Author

Bron, Esther, Smits, Marion, van Swieten, John, Niessen, Wiro, Klein, Stefan, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Wu, Guorong, editor, Zhang, Daoqiang, editor, and Zhou, Luping, editor

Published
2014
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193. Free-Form Deformation Using Lower-Order B-spline for Nonrigid Image Registration

Author

Sun, Wei, Niessen, Wiro J., Klein, Stefan, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Golland, Polina, editor, Hata, Nobuhiko, editor, Barillot, Christian, editor, Hornegger, Joachim, editor, and Howe, Robert, editor

Published
2014
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194. Fast Multidimensional B-spline Interpolation Using Template Metaprogramming

Author

Huizinga, Wyke, Klein, Stefan, Poot, Dirk H. J., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Kobsa, Alfred, editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Weikum, Gerhard, editor, Ourselin, Sébastien, editor, and Modat, Marc, editor

Published
2014
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195. Non-rigid Groupwise Image Registration for Motion Compensation in Quantitative MRI

Author

Huizinga, Wyke, Poot, Dirk H. J., Guyader, Jean-Marie, Smit, Henk, van Kranenburg, Matthijs, van Geuns, Robert-Jan M., Uitterdijk, André, van Beusekom, Heleen M. M., Coolen, Bram F., Leemans, Alexander, Niessen, Wiro J., Klein, Stefan, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Kobsa, Alfred, editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Weikum, Gerhard, editor, Ourselin, Sébastien, editor, and Modat, Marc, editor

Published
2014
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196. Randomly Perturbed Free-Form Deformation for Nonrigid Image Registration

Author

Sun, Wei, Niessen, Wiro J., Klein, Stefan, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Kobsa, Alfred, editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Weikum, Gerhard, editor, Ourselin, Sébastien, editor, and Modat, Marc, editor

Published
2014
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