151. Sleep characteristics in type 1 diabetes and associations with glycemic control: systematic review and meta-analysis.
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Reutrakul, Sirimon, Thakkinstian, Ammarin, Anothaisintawee, Thunyarat, Chontong, Sasipas, Borel, Anne-Laure, Perfect, Michelle M., Janovsky, Carolina Castro Porto Silva, Kessler, Romain, Schultes, Bernd, Harsch, Igor Alexander, van Dijk, Marieke, Bouhassira, Didier, Matejko, Bartlomiej, Lipton, Rebecca B., Suwannalai, Parawee, Chirakalwasan, Naricha, Schober, Anne-Katrin, and Knutson, Kristen L.
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SLEEP , *TYPE 2 diabetes , *GLUCOSE intolerance , *META-analysis , *BLOOD sugar monitoring - Abstract
Objectives: The association between inadequate sleep and type 2 diabetes has garnered much attention, but little is known about sleep and type 1 diabetes (T1D). Our objectives were to conduct a systematic review and meta-analysis comparing sleep in persons with and without T1D, and to explore relationships between sleep and glycemic control in T1D.Methods: Studies were identified from Medline and Scopus. Studies reporting measures of sleep in T1D patients and controls, and/or associations between sleep and glycemic control, were selected.Results: A total of 22 studies were eligible for the meta-analysis. Children with T1D had shorter sleep duration (mean difference [MD] = -26.4 minutes; 95% confidence interval [CI] = -35.4, -17.7) than controls. Adults with T1D reported poorer sleep quality (MD in standardized sleep quality score = 0.51; 95% CI = 0.33, 0.70), with higher scores reflecting worse sleep quality) than controls, but there was no difference in self-reported sleep duration. Adults with TID who reported sleeping >6 hours had lower hemoglobin A1c (HbA1c) levels than those sleeping ≤6 hours (MD = -0.24%; 95% CI = -0.47, -0.02), and participants reporting good sleep quality had lower HbA1c than those with poor sleep quality (MD = -0.19%; 95% CI = -0.30, -0.08). The estimated prevalence of obstructive sleep apnea (OSA) in adults with TID was 51.9% (95% CI = 31.2, 72.6). Patients with moderate-to-severe OSA had a trend toward higher HbA1c (MD = 0.39%, 95% CI = -0.08, 0.87).Conclusion: T1D was associated with poorer sleep and high prevalence of OSA. Poor sleep quality, shorter sleep duration, and OSA were associated with suboptimal glycemic control in T1D patients. [ABSTRACT FROM AUTHOR]- Published
- 2016
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