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151. Rahmenbedingungen

Author

Handschu, R., Fiedler, Christine, editor, Köhrmann, Martin, editor, and Kollmar, Rainer, editor

Published
2017
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170. Akuttherapie

Author

Köhrmann, M., Sauer, E. M., Fiedler, Christine, editor, Köhrmann, Martin, editor, and Kollmar, Rainer, editor

Published
2017
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176. Neck cooling induces blood pressure increase and peripheral vasoconstriction in healthy persons.

Author

Koehn, Julia, Wang, Ruihao, de Rojas Leal, Carmen, Kallmünzer, Bernd, Winder, Klemens, Köhrmann, Martin, Kollmar, Rainer, Schwab, Stefan, and Hilz, Max J.

Subjects
*BLOOD pressure, *VASOCONSTRICTION, *CEREBRAL circulation, *COOLING, *NECK
Abstract

Introduction: Noninvasive temperature modulation by localized neck cooling might be desirable in the prehospital phase of acute hypoxic brain injuries. While combined head and neck cooling induces significant discomfort, peripheral vasoconstriction, and blood pressure increase, localized neck cooling more selectively targets blood vessels that supply the brain, spares thermal receptors of the face and skull, and might therefore cause less discomfort cardiovascular side effects compared to head- and neck cooling. The purpose of this study is to assess the effects of noninvasive selective neck cooling on cardiovascular parameters and cerebral blood flow velocity (CBFV). Methods: Eleven healthy persons (6 women, mean age 42 ± 11 years) underwent 90 min of localized dorsal and frontal neck cooling (EMCOOLS Brain.Pad™) without sedation. Before and after cooling onset, and after every 10 min of cooling, we determined rectal, tympanic, and neck skin temperatures. Before and after cooling onset, after 60- and 90-min cooling, we monitored RR intervals (RRI), systolic, diastolic blood pressures (BPsys, BPdia), laser Doppler skin blood flow (SBF) at the index finger pulp, and CBFV at the proximal middle cerebral artery (MCA). We compared values before and during cooling by analysis of variance for repeated measurements with post hoc analysis (significance: p < 0.05). Results: Neck skin temperature dropped significantly by 9.2 ± 4.5 °C (minimum after 40 min), while tympanic temperature decreased by only 0.8 ± 0.4 °C (minimum after 50 min), and rectal temperature by only 0.2 ± 0.3 °C (minimum after 60 min of cooling). Index finger SBF decreased (by 83.4 ± 126.0 PU), BPsys and BPdia increased (by 11.2 ± 13.1 mmHg and 8.0 ± 10.1 mmHg), and heart rate slowed significantly while MCA-CBFV remained unchanged during cooling. Conclusions: While localized neck cooling prominently lowered neck skin temperature, it had little effect on tympanic temperature but significantly increased BP which may have detrimental effects in patients with acute brain injuries. [ABSTRACT FROM AUTHOR]

Published
2020
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185. Rahmenbedingungen

Author

Handschu, René, Fiedler, Christine, editor, Köhrmann, Martin, editor, and Kollmar, Rainer, editor

Published
2013
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195. Akuttherapie

Author

Köhrmann, Martin, Hauer, Eva-Maria, Fiedler, Christine, editor, Köhrmann, Martin, editor, and Kollmar, Rainer, editor

Published
2013
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199. Erratum

Author

Fiedler, Christine, Fiedler, Christine, editor, Köhrmann, Martin, editor, and Kollmar, Rainer, editor

Published
2013
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200. Granulocyte colony-stimulating factor does not promote neurogenesis after experimental intracerebral haemorrhage.

Author

Kallmünzer, Bernd, Tauchi, Miyuki, Schlachetzki, Johannes C., Machold, Kristin, Schmidt, Ariana, Winkler, Jürgen, Schwab, Stefan, and Kollmar, Rainer

Subjects
*GRANULOCYTES, *LEUCOCYTES, *DEVELOPMENTAL neurobiology, *INTRACEREBRAL hematoma, *CEREBRAL hemorrhage, *LABORATORY rats, *BRAIN damage
Abstract

Background Hematopoietic growth factors have been suggested to induce neuroprotective and regenerative effects in various animal models of cerebral injury. However, the pathways involved remain widely unexplored. Aims This study aimed to investigate effects of local and systemic administration of granulocyte colony-stimulating factor on brain damage, functional recovery, and cerebral neurogenesis in an intracerebral haemorrhage whole blood injection model in rats. Methods Eight-week-old male Wistar rats ( n = 100) underwent induction of striatal intracerebral haemorrhage by autologous whole blood injection or sham procedure and were randomly assigned to either (a) systemic treatment with granulocyte colony-stimulating factor (60 μg/kg) for five-days; (b) single intracerebral injection of granulocyte colony-stimulating factor (60 μg/kg) into the cavity; or (c) application of vehicle for five-days. Bromodeoxyuridine-labelling and immunohistochemistry were used to analyze proliferation and survival of newly born cells in the sub-ventricular zone and the hippocampal dentate gyrus. Moreover, functional deficits and lesion volume were assessed until day 42 after intracerebral haemorrhage. Results Differences in lesion size or hemispheric atrophy between granulocyte colony-stimulating factor-treated and control groups did not reach statistical significance. Neither systemic, nor local granulocyte colony-stimulating factor administration induced neurogenesis within the dentate gyrus or the sub-ventricular zone. The survival of newborn cells in these regions was prevented by intracerebral granulocyte colony-stimulating factor application. A subtle benefit in functional recovery at day 14 after intracerebral haemorrhage induction was observed after granulocyte colony-stimulating factor treatment. Conclusion There was a lack of neuroprotective or neuroregenerative effects of granulocyte colony-stimulating factor in the present rodent model of intracerebral haemorrhage. Conflicting results from functional outcome assessment require further research. [ABSTRACT FROM AUTHOR]

Published
2014
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