811 results on '"Kraneveld, Aletta D."'
Search Results
152. Mental resilience, perceived immune functioning, and health
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Lantman, Marith Van Schrojenstein, Mackus, Marlou, Otten, Leila S., de Kruijff, Deborah, van de Loo, Aurora J. A. E., Kraneveld, Aletta D., Garssen, Johan, Verster, Joris C., Afd Pharmacology, LS IRAS Tox Algemeen, Pharmacology, Afd Pharmacology, LS IRAS Tox Algemeen, and Pharmacology
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immune functioning ,media_common.quotation_subject ,Vitality ,vitality ,mental resilience ,03 medical and health sciences ,0302 clinical medicine ,Optimism ,Quality of life (healthcare) ,030212 general & internal medicine ,General Nursing ,media_common ,Original Research ,Journal of Multidisciplinary Healthcare ,Perspective (graphical) ,Stressor ,health ,General Medicine ,Mental health ,quality of life ,Trait ,Psychological resilience ,Psychology ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Marith Van Schrojenstein Lantman,1 Marlou Mackus,1 Leila S Otten,1 Deborah de Kruijff,1 Aurora JAE van de Loo,1,2 Aletta D Kraneveld,1,2 Johan Garssen,1,3 Joris C Verster1,2,4 1Division of Pharmacology, Utrecht University, Utrecht, the Netherlands; 2Institute for Risk Assessment Sciences, Utrecht University, Utrecht,the Netherlands; 3Nutricia Research, Utrecht, the Netherlands; 4Centre for Human Psychopharmacology, Swinburne University, Melbourne, Australia Background: Mental resilience can be seen as a trait that enables an individual to recover from stress and to face the next stressor with optimism. People with resilient traits are considered to have a better mental and physical health. However, there are limited data available assessing the relationship between resilient individuals and their perspective of their health and immune status. Therefore, this study was conducted to examine the relationship between mental resilience, perceived health, and perceived immune status. Methods: A total of 779 participants recruited at Utrecht University completed a questionnaire consisting of demographic characteristics, the brief resilience scale for the assessment of mental resilience, the immune function questionnaire (IFQ), and questions regarding their perceived health and immune status. Results: When correcting for gender, age, height, weight, smoker status, amount of cigarettes smoked per week, alcohol consumption status, amount of drinks consumed per week, drug use, and frequency of past year drug use, mental resilience was significantly correlated with perceived health (r=0.233, p=0.0001), perceived immune functioning (r=0.124, p=0.002), and IFQ score (r=−0.185, p=0.0001). Conclusion: A significant, albeit modest, relationship was found between mental resilience and perceived immune functioning and health. Keywords: mental resilience, immune functioning, health, vitality, quality of life
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- 2017
153. Dietary Nutrient Intake, Alcohol Metabolism, and Hangover Severity
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Verster, Joris C., Vermeulen, Sterre A., van de Loo, Aurora J. A. E., Balikji, Stephanie, Kraneveld, Aletta D., Garssen, Johan, Scholey, Andrew, Afd Pharmacology, One Health Toxicologie, dIRAS RA-1, Pharmacology, Afd Pharmacology, One Health Toxicologie, dIRAS RA-1, and Pharmacology
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caloric intake ,maximum likelihood method ,vomiting ,food frequency questionnaire ,urinalysis ,lcsh:Medicine ,Physiology ,Hangovers ,Alcohol ,vitamin D ,Urine ,somnolence ,chemistry.chemical_compound ,0302 clinical medicine ,Nutrient ,sensitivity analysis ,social drinker ,alcohol blood level ,030212 general & internal medicine ,media_common ,clinical article ,barbituric acid derivative ,alcohol ,zinc ,alcohol dehydrogenase ,article ,General Medicine ,cannabinoid ,fluid intake ,opiate ,Nicotinic acid ,appetite ,female ,nutritional assessment ,hangover ,diet supplementation ,depression ,bootstrapping ,behavior assessment ,disease severity ,benzodiazepine ,alcoholic beverage ,headache ,stomach pain ,energy conversion ,media_common.quotation_subject ,alcohol consumption ,amphetamine ,cocaine ,psychosocial environment ,shivering ,03 medical and health sciences ,body weight ,male ,nutrients ,medicine ,Vitamin D and neurology ,controlled study ,human ,Ethanol metabolism ,nicotinic acid ,nicotinamide adenine dinucleotide ,dizziness ,business.industry ,lcsh:R ,Acetaldehyde ,alcohol oxidation ,Appetite ,Nutrients ,medicine.disease ,chemistry ,aldehyde dehydrogenase isoenzyme 2 ,alcohol metabolism ,lifestyle modification ,business ,dietary intake ,030217 neurology & neurosurgery ,acetaldehyde - Abstract
Several dietary components have been shown to influence alcohol metabolism and thereby potentially affect the development of a hangover. From the literature, it is evident that dietary nicotinic acid and zinc play a pivotal role in the oxidation of ethanol into acetaldehyde. The aim of the current study was to associate dietary intake of nicotinic acid and zinc with hangover severity. To this end, data from n = 23 healthy social drinkers who participated in a naturalistic hangover study were analyzed. n = 10 of them reported to be hangover-resistant (the control group), whereas n = 13 reported to have regular hangovers (the hangover-sensitive group). Two 24 h dietary recall records were completed, one for the day of alcohol consumption and another one for an alcohol-free control day. Dietary nutrient intake was averaged and did not significantly differ between hangover-sensitive and hangover-resistant drinkers. For the hangover-sensitive drinkers, partial correlations with overall hangover severity were computed, controlling for estimated blood alcohol concentration. A bootstrapping technique was applied to account for the relatively small sample size. The results showed that dietary intake of nicotinic acid (rPB = &minus, 0.521) and zinc (rPB = &minus, 0.341) were significantly and negatively associated (p <, 0.002) with overall hangover severity. Dietary zinc intake was also significantly and negatively associated with severity of vomiting (rPB = &minus, 0.577, p <, 0.002). No significant associations with hangover severity were found for other nutrients, such as fat and fibers. In conclusion, this study suggests that social drinkers who have a higher dietary intake of nicotinic acid and zinc report significantly less severe hangovers. As hangover-resistant and hangover-sensitive drinkers had a similar dietary nutrient intake, the claim of being hangover-resistant must be based on other unknown biopsychosocial factors. These findings should be replicated in a larger sample and include more elaborate food frequency questionnaires or nutrient-specific dietary intake records for zinc and nicotinic acid, and preferably accompanied by nutrient assessments in urine and/or blood.
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- 2019
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154. The cross-talk between microbiome and asthm: exploring associations and challenges
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Abdel-Aziz, Mahmoud I, Vijverberg, Susanne J H, Neerincx, Anne H, Kraneveld, Aletta D, Maitland-van der Zee, Anke H, Afd Pharmacology, Pharmacology, and Pharmacoepidemiology and Clinical Pharmacology
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omics- and systems biology ,asthma ,regulatory aspects ,clinical immunology - Abstract
With the advancement of high-throughput DNA/RNA sequencing and computational analysis techniques, commensal bacteria are now considered almost as important as pathological ones. Understanding the interaction between these bacterial microbiota, host and asthma is crucial to reveal their role in asthma pathophysiology. Several airway and/or gut microbiome studies have shown associations between certain bacterial taxa and asthma. However, challenges remain before gained knowledge from these studies can be implemented into clinical practice, such as inconsistency between studies in choosing sampling compartments and/or sequencing approaches, variability of results in asthma studies, and not taking into account medication intake and diet composition especially when investigating gut microbiome. Overcoming those challenges, will help to better understand the complex asthma disease process. The therapeutic potential of using pro- and pre-biotics to prevent or reduce risk of asthma exacerbations requires further investigation. This review will focus on methodological issues regarding setting up a microbiome study, recent developments in asthma bacterial microbiome studies, challenges and future therapeutic potential. This article is protected by copyright. All rights reserved.
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- 2019
155. Activation of resolution pathways to prevent and fight chronic inflammation: lessons from asthma and inflammatory bowel disease
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Barnig, Cindy, Bezema, Tjitske, Calder, Philip, Charloux, Anne, Frossard, Nelly, Garssen, Johan, Haworth, Oliver, Dilevskaya, Ksenia, Levi-Schaffer, Francesca, Lonsdorfer, Evelyne, Wauben, Marca, Kraneveld, Aletta D., and te Velde, Anje A.
- Abstract
Formerly considered as a passive process, the resolution of acute inflammation is now recognized as an active host response, with a cascade of coordinated cellular and molecular events that promotes termination of the inflammatory response and initiates tissue repair and healing. In a state of immune fitness, the resolution of inflammation is contained in time and space enabling the restoration of tissue homeostasis. There is increasing evidence that poor and/or inappropriate resolution of inflammation participates in the pathogenesis of chronic inflammatory diseases, extending in time the actions of pro-inflammatory mechanisms, and responsible in the long run for excessive tissue damage and pathology. In this review, we will focus on how resolution can be the target for therapy in “Th1/Th17 cell-driven” immune diseases and “Th2 cell-driven” immune diseases, with inflammatory bowel diseases (IBD) and asthma, as relevant examples. We describe the main cells and mediators stimulating the resolution of inflammation and discuss how pharmacological and dietary interventions but also life style factors, physical and psychological conditions, might influence the resolution phase. A better understanding of the impact of endogenous and exogenous factors on the resolution of inflammation might open a whole area in the development of personalized therapies in non-resolving chronic inflammatory diseases.
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- 2019
156. Role of TLR4 in the gut-brain axis in Parkinson's disease: a translational study from men to mice
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Perez-Pardo, Paula, Dodiya, Hemraj B, Engen, Phillip A, Forsyth, Christopher B, Huschens, Andrea M, Shaikh, Maliha, Voigt, Robin M, Naqib, Ankur, Green, Stefan J, Kordower, Jeffrey H, Shannon, Kathleen M, Garssen, Johan, Kraneveld, Aletta D, Keshavarzian, Ali, Afd Pharmacology, Sub Interdisciplinary translational Phar, and Pharmacology
- Abstract
OBJECTIVE: Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible role of the gut-brain axis in neurodegenerative diseases. Given the prominence of dysbiosis and colonic dysfunction in patients with Parkinson's disease (PD), we propose that toll-like receptor 4 (TLR4)-mediated intestinal dysfunction could contribute to intestinal and central inflammation in PD-related neurodegeneration. DESIGN: To test this hypothesis we performed studies in both human tissue and a murine model of PD. Inflammation, immune activation and microbiota composition were measured in colonic samples from subjects with PD and healthy controls subjects and rotenone or vehicle-treated mice. To further assess the role of the TLR4 signalling in PD-induced neuroinflammation, we used TLR4-knockout (KO) mice in conjunction with oral rotenone administration to model PD. RESULTS: Patients with PD have intestinal barrier disruption, enhanced markers of microbial translocation and higher pro-inflammatory gene profiles in the colonic biopsy samples compared with controls. In this regard, we found increased expression of the bacterial endotoxin-specific ligand TLR4, CD3+ T cells, cytokine expression in colonic biopsies, dysbiosis characterised by a decrease abundance of SCFA-producing colonic bacteria in subjects with PD. Rotenone treatment in TLR4-KO mice revealed less intestinal inflammation, intestinal and motor dysfunction, neuroinflammation and neurodegeneration, relative to rotenone-treated wild-type animals despite the presence of dysbiotic microbiota in TLR4-KO mice. CONCLUSION: Taken together, these studies suggest that TLR4-mediated inflammation plays an important role in intestinal and/or brain inflammation, which may be one of the key factors leading to neurodegeneration in PD.
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- 2019
157. Psychological co-morbidities in COPD: Targeting systemic inflammation, a benefit for both?
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Pelgrim, Charlotte E., Peterson, Julia D., Gosker, Harry R., Schols, Annemie M.W.J., van Helvoort, Ardy, Garssen, Johan, Folkerts, Gert, Kraneveld, Aletta D., Afd Pharmacology, Pharmacology, Afd Pharmacology, and Pharmacology
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0301 basic medicine ,VITAMIN-D DEFICIENCY ,medicine.medical_specialty ,MILD COGNITIVE IMPAIRMENT ,MULTI-NUTRIENT DIET ,Anti-Inflammatory Agents ,Inflammation ,Comorbidity ,Anxiety ,Systemic inflammation ,OBSTRUCTIVE PULMONARY-DISEASE ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Quality of life ,QUALITY-OF-LIFE ,medicine ,Pharmaceutical and nutritional interventions ,Animals ,Humans ,COPD ,Molecular Targeted Therapy ,NICOTINIC ACETYLCHOLINE-RECEPTOR ,OXIDATIVE STRESS ,Intensive care medicine ,Depression (differential diagnoses) ,Pharmacology ,business.industry ,Depression ,Brain ,MOUSE MODEL ,WHITE-MATTER LESIONS ,medicine.disease ,Mental health ,respiratory tract diseases ,ALZHEIMERS-DISEASE ,030104 developmental biology ,Cognitive impairment ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
COPD is a chronic lung disease characterized by persistent respiratory symptoms and airflow limitation due to airway and/or alveolar abnormalities. Furthermore, COPD is often characterized by extrapulmonary manifestations and comorbidities worsening COPD progression and quality of life. A neglected comorbidity in COPD management is mental health impairment defined by anxiety, depression and cognitive problems. This paper summarizes the evidence for impaired mental health in COPD and focuses on current pharmacological intervention strategies. In addition, possible mechanisms in impaired mental health in COPD are discussed with a central role for inflammation. Many comorbidities are associated with multi-organ-associated systemic inflammation in COPD. Considering the accumulative evidence for a major role of systemic inflammation in the development of neurological disorders, it can be hypothesized that COPD-associated systemic inflammation also affects the function of the brain and is an interesting therapeutic target for nutra- and pharmaceuticals.
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- 2019
158. Mast cells and nerves tickle in the tummy Implications for inflammatory bowel disease and irritable bowel syndrome
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Rijnierse, Anneke, Nijkamp, Frans P., and Kraneveld, Aletta D.
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- 2007
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159. Role of mucosal mast cells in early vascular permeability changes of intestinal DTH reaction in the rat
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Kraneveld, Aletta D., Muis, Thea, Koster, Andries S., and Nijkamp, Frans P.
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Permeability -- Research ,Mast cells -- Research ,Delayed hypersensitivity -- Research ,Rats -- Research ,Biological sciences - Abstract
Research was conducted to examine the role of mucosal mast cells in the early component of intestinal delayed-type hypersensitivity (DTH) reaction in the rat. To study the effects of mast cell stabilization on the early events of the DTH reaction, doxantrazole was used in rats. This resulted in a substantial inhibition of the DTH-induced vascular leakage and an increase in serum RMCP II. Results confirm the significant role of mucosal mast cells in early vascular leakage changes of intestinal DTH reactions.
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- 1998
160. The Combination Therapy of Dietary Galacto-Oligosaccharides With Budesonide Reduces Pulmonary Th2 Driving Mediators and Mast Cell Degranulation in a Murine Model of House Dust Mite Induced Asthma
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Verheijden, Kim A T, Braber, Saskia, Leusink-Muis, Thea, Jeurink, Prescilla V, Thijssen, Suzan, Kraneveld, Aletta D, Garssen, Johan, Folkerts, Gert, Willemsen, Linette E M, Afd Pharmacology, Pharmacology, Afd Pharmacology, and Pharmacology
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0301 basic medicine ,Budesonide ,Allergy ,Anti-Inflammatory Agents ,Oligosaccharides ,Bio-Organic Chemistry ,Cell Degranulation ,Mice ,0302 clinical medicine ,Immunology and Allergy ,Mast Cells ,house dust mite ,Lung ,Th1-Th2 Balance ,Original Research ,Mice, Inbred BALB C ,medicine.diagnostic_test ,biology ,Pyroglyphidae ,Degranulation ,Mast cell ,Combined Modality Therapy ,medicine.anatomical_structure ,Cytokines ,medicine.drug ,lcsh:Immunologic diseases. Allergy ,budesonide ,Combination therapy ,Immunology ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,Th2 Cells ,medicine ,Hypersensitivity ,Animals ,Humans ,galacto-oligosaccharides ,Antigens, Dermatophagoides ,House dust mite ,business.industry ,Eosinophil ,asthma ,medicine.disease ,biology.organism_classification ,allergy ,Disease Models, Animal ,030104 developmental biology ,Bronchoalveolar lavage ,Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] ,Dietary Supplements ,lcsh:RC581-607 ,business ,030215 immunology - Abstract
Background: Dietary non-digestible galacto-oligosaccharides (GOS) suppress allergic responses in mice sensitized and challenged with house dust mite (HDM). Budesonide is the standard therapy for allergic asthma in humans but is not always completely effective. Aim: To compare the efficacy of budesonide or different doses of GOS alone or with a combination therapy of budesonide and GOS on HDM-allergic responses in mice. Methods:BALB/c mice were sensitized and challenged with HDM, while fed a control diet or a diet supplemented with 1 or 2.5 w/w% GOS, and either or not oropharyngeally instilled with budesonide. Systemic and local inflammatory markers, such as mucosal mast cell protease-1 (mMCP-1) in serum, pulmonary CCL17, CCL22, and IL-33 concentrations and inflammatory cell influx in the bronchoalveolar lavage fluid (BALF) were determined. Results: Budesonide or GOS alone suppressed the number of eosinophils in the BALF of HDM allergic mice whereas budesonide either or not combined with GOS lowered both eosinophil and lymphocyte numbers in the BALF of HDM-allergic mice. Both 1 w/w% and 2.5 w/w% GOS and/or budesonide suppressed serum mMCP-1 concentrations. However, budesonide nor GOS alone was capable of reducing Th2 driving chemokines CCL17, CCL22 and IL-33 protein levels in supernatants of lung homogenates of HDM allergic mice, whereas the combination therapy did. Moreover, IL-13 concentrations were only significantly suppressed in mice treated with budesonide while fed GOS. A similar tendency was observed for the frequency of GATA3+CD4+ Th2 and CD4+RORγt+ Th17 cells in the lungs of the allergic mice. Conclusion: Dietary intervention using GOS may be a novel way to further improve the efficacy of anti-inflammatory drug therapy in allergic asthma by lowering Th2 driving mediators and mast cell degranulation.
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- 2018
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161. The Association of Insomnia, Perceived Immune Functioning, and Irritable Bowel Syndrome Complaints
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Balikji, Stephanie, Mackus, Marlou, Brookhuis, Karel A, Garssen, Johan, Kraneveld, Aletta D, Roth, Thomas, Verster, Joris C, Afd Pharmacology, Pharmacology, Clinical Neuropsychology, Afd Pharmacology, and Pharmacology
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DISORDERS ,insomnia ,WAKE-UP CALL ,BIOMARKERS ,lcsh:Medicine ,Disease ,Article ,DISEASE ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Quality of life ,QUALITY-OF-LIFE ,medicine ,Insomnia ,030212 general & internal medicine ,sleep ,DISRUPTED SLEEP ,Association (psychology) ,Irritable bowel syndrome ,GASTROINTESTINAL SYMPTOMS ,irritable bowel syndrome ,business.industry ,lcsh:R ,CYTOKINES ,FUNDAMENTALS ,perceived immune functioning ,General Medicine ,medicine.disease ,Mood ,quality of life ,DISTURBANCES ,030211 gastroenterology & hepatology ,Sleep onset latency ,medicine.symptom ,business ,Clinical psychology - Abstract
Background: Irritable bowel syndrome (IBS) can have a significant negative impact on quality of life, mood and wellbeing. The aim of this study was to investigate the association between experiencing IBS symptoms and insomnia, and perceived health status. Method: An online survey was conducted among n = 1950 Dutch university students (83.6% women). IBS was assessed with the Birmingham IBS Symptom Questionnaire, quality of life with the WHO-5 wellbeing index, and sleep outcomes with the SLEEP-50 questionnaire. Perceived immune functioning and general health were assessed using 1-item scales. Results: IBS symptom severity was significantly associated with insomnia complaints (r = 0.32, p = 0.0001), sleep quality (r = &minus, 0.21, p = 0.0001), sleep onset latency (r = 0.11, p = 0.0001) and the number of nightly awakenings (r = 0.24, p = 0.0001). Total sleep time was not significantly associated with IBS symptom severity. Significant correlations were also found between IBS symptom severity and perceived general health (r = &minus, 0.30, p = 0.0001), perceived immune functioning (r= &minus, 0.25, p = 0.0001), and quality of life (r = &minus, 0.24, p = 0.0001). Conclusions: Experiencing IBS complaints is associated with reduced perceived immune functioning, a poorer perception of general health, and sleep disturbances. These effects are reflected in a significantly lower reported quality of life in subjects with more IBS and/or sleep complaints.
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- 2018
162. Beneficial effect of tachykinin NK1 receptor antagonism in the development of hapten-induced colitis in mice
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Rijnierse, Anneke, van Zijl, Kim M.F., Koster, Andries S., Nijkamp, Frans P., and Kraneveld, Aletta D.
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- 2006
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163. Association of endopeptidases, involved in SARS‐CoV‐2 infection, with microbial aggravation in sputum of severe asthma.
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Abdel‐Aziz, Mahmoud I., Kermani, Nazanin Zounemat, Neerincx, Anne H., Vijverberg, Susanne J. H., Guo, Yike, Howarth, Peter, Dahlen, Sven‐Erik, Djukanovic, Ratko, Sterk, Peter J., Kraneveld, Aletta D., Maitland‐van der Zee, Anke H., Chung, Kian Fan, and Adcock, Ian M.
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ENDOPEPTIDASES ,ASTHMA ,SARS-CoV-2 ,COUGH ,SPUTUM ,CELL receptors - Abstract
To the Editor, COVID-19 can be a serious multisystem disease caused by the SARS-CoV-2 coronavirus, and the current pandemic has affected more than 80 million people and caused nearly two million deaths worldwide. Therefore, the aim of this study was to investigate associations of sputum endopeptidases gene expression with metagenomics composition and whether they could be used to stratify asthma patients according to risk of SARS-CoV-2 infection. In contrast, non-T2 asthma, particularly neutrophilic asthma, has been associated with higher ACE2 and endopeptidases (TMPRSS2 and furin) expression as compared with the T2-high phenotype4,5 that might imply a worse outcome with COVID-19 infection. [Extracted from the article]
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- 2021
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164. The tachykinin NK1 receptor is crucial for the development of non-atopic airway inflammation and hyperresponsiveness
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van der Kleij, Hanneke P.M., Kraneveld, Aletta D., Redegeld, Frank A.M., Gerard, Norma P., Morteau, Olivier, and Nijkamp, Frans P.
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- 2003
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165. Microvascular permeability in isolated vascularly perfused small intestine of rats
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Kraneveld, Aletta D., Koster, Andries S., and Nijkamp, Frans P.
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Intestine, Small -- Physiological aspects ,Rats -- Anatomy ,Permeability -- Research ,Biological sciences - Abstract
Collection of venous samples and arterial infusion of tracer molecules facilitate the analysis of the permeability of intestinal microvascular permeability in isolated vascularly perfused small intestine of rats. Properties of permeability in the rat are similar to those in the cat. Impairment of endothelium and histamine-incited alterations can be determined in a quantitatively reliable way.
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- 1994
166. Early-life antibiotic use and risk of attention-deficit hyperactivity disorder and autism spectrum disorder: results of a discordant twin study.
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Slob, Elise M A, Brew, Bronwyn K, Vijverberg, Susanne J H, Dijs, Talitha, Beijsterveldt, Catharina E M van, Koppelman, Gerard H, Bartels, Meike, Dolan, Conor V, Larsson, Henrik, Lundström, Sebastian, Lichtenstein, Paul, Gong, Tong, Zee, Anke H Maitland-van der, Kraneveld, Aletta D, Almqvist, Catarina, Boomsma, Dorret I, van Beijsterveldt, Catharina E M, and Maitland-van der Zee, Anke H
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AUTISM spectrum disorders ,ATTENTION-deficit hyperactivity disorder ,TWIN studies ,ANTIBIOTICS ,TWINS ,RESEARCH ,RESEARCH methodology ,MEDICAL cooperation ,EVALUATION research ,COMPARATIVE studies ,LONGITUDINAL method - Abstract
Background: Development of the gut-brain axis in early life may be disturbed by antibiotic use. It has been hypothesized that this disturbance may contribute to development of neurodevelopmental disorders, including autism spectrum disorder and attention-deficit hyperactivity disorder. We aimed to assess the association between antibiotic use in early life and the risk of developing attention-deficit hyperactivity disorder or autism spectrum disorder, while controlling for shared genetic and environmental factors in a discordant twin design.Methods: We conducted a cohort study in twins (7-12 years; 25 781 twins) from the Netherlands Twin Register (NTR) and a replication study in the Childhood and Adolescent Twin Study in Sweden (CATSS; 7946 9-year-old twins). Antibiotic use was recorded before age 2 years. Attention-deficit hyperactivity disorder and autism spectrum disorder were parent-reported in the Netherlands Twin Register and register-based in the Childhood and Adolescent Twin Study in Sweden.Results: Early-life antibiotic use was associated with increased risk of attention-deficit hyperactivity disorder development [pooled odds ratio (OR) 1.10, 95% confidence interval (CI) 1.02-1.17] and autism spectrum disorder (pooled OR 1.15, 95% CI 1.06-1.25) in a case-control design. When restricting to monozygotic twin pairs discordant for the outcome, associations disappeared for both disorders in both cohorts (attention-deficit hyperactivity disorder OR 0.90, 95% CI 0.48-1.69 and OR 0.80, 95% CI 0.37-1.76, and autism spectrum disorder OR 0.66, 95% CI 0.38-1.16 and OR 0.29, 95% CI 0.02-4.50, respectively).Conclusions: Our findings suggest that the association between early-life antibiotic use and risk of attention-deficit hyperactivity and autism spectrum disorder may be confounded by shared familial environment and genetics. [ABSTRACT FROM AUTHOR]- Published
- 2021
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167. Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson's Disease
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Perez-Pardo, Paula, Broersen, Laus M, Kliest, Tessa, van Wijk, Nick, Attali, Amos, Garssen, Johan, Kraneveld, Aletta D, Afd Pharmacology, and Pharmacology
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dietary intervention ,motor-symptoms ,Parkinson’s disease ,levodopa ,non-motor symptoms - Abstract
Though Parkinson's disease (PD) clinical picture is generally dominated by motor impairment, non-motor symptoms, such as cognitive decline and gastrointestinal dysfunctions, may develop before motor symptoms and have major effects on quality of life. L-3,4-di-hydroxy-phenylalanine (Levodopa) is the most commonly used treatment of motor symptoms but has serious side-effects with prolonged use and does not stop the degenerative process. Moreover, gastrointestinal dysfunctions interfere with the absorption of levodopa and modify its effectiveness. Since most patients are on levodopa treatment, there is a need for combinational therapies that allow for an effective reduction of both motor and non-motor symptoms. We have recently shown that a diet containing precursors and cofactors required for membrane phospholipid synthesis, as well as prebiotic fibers, had therapeutic effects in a PD mouse model. We now investigate the effects of combined administration of the same diet together with levodopa in the rotenone model of PD. Mice were injected with rotenone or vehicle in the striatum. The dietary intervention started after full induction of motor symptoms. The effects of dietary intervention and oral treatment with different doses of levodopa were assessed weekly. Motor and cognitive functions were tested, intestinal transit was analyzed and histological examination of the brain and the colon was assessed. Our results confirm our previous findings that rotenone-induced motor and non-motor problems were alleviated by the Active diet (AD). Levodopa showed an additive beneficial effect on rotarod performance in rotenone-treated animals fed with the AD. No negative interaction effects were found between the AD and levodopa. Our findings suggest that the dietary intervention might confer additional clinical benefits on patients receiving levodopa treatment.
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- 2018
168. Corrigendum 'Transcriptional modulation of pattern recognition receptors in chronic colitis in mice is accompanied with Th1 and Th17 response' [Biochem. Biophys. Rep. 12 (2017) 29-39]
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Zheng, Bin, Morgan, Mary E, van de Kant, Hendrik J G, Garssen, Johan, Folkerts, Gert, Kraneveld, Aletta D, Sub Developmental Biology, Afd Pharmacology, Pharmacology, Developmental Biology, Sub Developmental Biology, Afd Pharmacology, Pharmacology, and Developmental Biology
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0301 basic medicine ,business.industry ,Biophysics ,Pattern recognition receptor ,Biology ,Biochemistry ,digestive system diseases ,Inflammatory bowel disease ,Th cell responses ,lcsh:Biochemistry ,03 medical and health sciences ,030104 developmental biology ,Text mining ,lcsh:Biology (General) ,Cancer research ,lcsh:QD415-436 ,business ,Chronic colitis ,lcsh:QH301-705.5 ,Toll like receptors ,Research Article - Abstract
Pattern recognition receptors (PRRs) may contribute to inflammatory bowel diseases (IBD) development due to their microbial-sensing ability and the unique microenvironment in the inflamed gut. In this study, the PRR mRNA expression profile together with T cell-associated factors in the colon was examined using a chronic colitis mice model. 8–12 week old C57BL/6 mice were exposed to multiple dextran sodium sulfate (DSS) treatments interspersed with a rest period to mimic the course of chronic colitis. The clinical features and histological data were collected. The mRNA expressions of colonic PRRs, T cell-associated components were measured. Finally, the colons were scored for Foxp3+ cells. During chronic colitis, the histological data, but not the clinical manifestations demonstrated characteristic inflammatory symptoms in the distal colon. In contrast to acute colitis, the expression of all Toll-like receptors (Tlrs), except Tlr5 and Tlr9, was unaffected after repeated DSS treatments. The expression of Nod1 was decreased, while Nod2 increased. After third DSS treatment, only the expressions of Tlr3 and Tlr4 were significantly enhanced. Unlike other PRRs, decreased Tlr5 and increased Tlr9 mRNA expression persisted during the chronic colitis period. As the colitis progress, only the mRNA expression of Ifnγ and Il17 staid increased during chronic colitis, while the acute colitis-associated increase of Il23, and Il10 and Il12 was abolished. Finally, increased histological score of Foxp3+ cell in colon was found during the chronic colitis period. This study provides an expression pattern of PRRs during chronic colitis that is accompanied by a Th1- and Th17 cell-mediated immune response., Highlights • This study provides an extensive survey of PRRs in the colon during chronic DSS-induced colitis. • Chronic DSS colitis upregulates the mRNA expression of Tlr3, Tlr4, Tlr9 and Nod2. • As the DSS colitis progresses to a chronic status the expression of Tlr5 decreases. • The chronic DSS colitis results in a (progressive) increase of Th1 and Th17 cells.
- Published
- 2018
169. Susceptibility to Alcohol Hangovers: The Association with Self-Reported Immune Status
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van de Loo, Aurora J A E, Mackus, Marlou, van Schrojenstein Lantman, Marith, Kraneveld, Aletta D, Brookhuis, Karel A, Garssen, Johan, Scholey, Andrew, Verster, Joris C, Afd Pharmacology, Pharmacology, Afd Pharmacology, Pharmacology, and Clinical Neuropsychology
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Health, Toxicology and Mutagenesis ,030508 substance abuse ,lcsh:Medicine ,Hangovers ,Alcohol ,Article ,resistance ,Young Adult ,03 medical and health sciences ,chemistry.chemical_compound ,Alcohol hangover ,Surveys and Questionnaires ,Internal medicine ,0502 economics and business ,Blood alcohol ,medicine ,Humans ,Students ,Netherlands ,immune function ,Immune status ,business.industry ,alcohol ,05 social sciences ,lcsh:R ,Public Health, Environmental and Occupational Health ,Alcohol Drinking in College ,medicine.disease ,Alcohol-Induced Disorders ,chemistry ,hangover ,Blood Alcohol Content ,Female ,050211 marketing ,Self Report ,0305 other medical science ,business ,Alcoholic Intoxication ,Alcohol consumption - Abstract
Increasing evidence points at a role for the immune system in the genesis of the alcohol hangover. This study investigated the association between self-reported immune function and experiencing hangovers. Dutch students aged 18 to 30 years old were invited to complete an online survey. Eighteen items on immune-related complaints were completed to assess self-reported immune function. Alcohol consumption in the past month (with respect to usual consumption and the occasion of heaviest drinking) was also recorded. Subjects with an estimated blood alcohol concentration (eBAC) of 0.18% or higher on their heaviest drinking occasion in the prior month were included in the analyses. Self-reported immune function was compared between drinkers with a hangover and those who claimed to be hangover resistant. In total, of 481 subjects (79.2% women) with a mean (SD) age of 21.1 (1.9) years old were included in the analysis. Of these, 83.3% (n = 400) reported having hangovers and 16.8% (n = 81) claimed to be hangover resistant. Drinkers with hangovers had significantly higher self-reported overall immune function scores when compared to hangover-resistant drinkers (mean ±, SD = 10.5 ±, 3.6 versus 13.1 ±, 4.9, p = 0.0001), indicating a poorer immune status. In conclusion, experiencing alcohol hangovers is associated with significantly poorer self-reported immune function.
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- 2018
170. Susceptibility to alcohol hangovers: Not just a matter of being resilient
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van Schrojenstein Lantman, Marith, van de Loo, Aurora J A E, Mackus, Marlou, Kraneveld, Aletta D, Brookhuis, Karel A, Garssen, Johan, Verster, Joris C, Pharmacology, One Health Toxicologie, dIRAS RA-1, and Afd Pharmacology
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Adult ,Male ,medicine.medical_specialty ,Coping (psychology) ,Adolescent ,hangover from alcohol ,Alcohol ,Hangovers ,heavy drinking ,Young Adult ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Alcohol hangover ,Blood alcohol ,Taverne ,medicine ,Humans ,030212 general & internal medicine ,Young adult ,Students ,Psychiatry ,business.industry ,General Medicine ,Resilience, Psychological ,medicine.disease ,alcohol drinking ,chemistry ,Blood Alcohol Content ,Female ,Blood alcohol content ,coping behavior ,ethanol ,business ,Alcoholic Intoxication ,Alcohol consumption ,030217 neurology & neurosurgery - Abstract
Introduction Although most drinkers have experienced a hangover the day following heavy alcohol consumption, a minority claims to be hangover resistant despite consuming the same large quantities of alcohol as those reporting alcohol hangover. The aim of the current study was to examine if susceptibility to experiencing hangovers is related to a drinker's interpretation of wellbeing and psychological assets to bounce back. Methods A survey was conducted among 2295 Dutch students assessing their past month alcohol consumption patterns, and measuring mental resilience and wellbeing. Estimated peak blood alcohol concentration (e-pBAC) for their heaviest drinking occasion in the past month was computed for each participant. Data from participants who reported a past month hangover, i.e. hangover sensitive drinkers, were compared with hangover resistant drinkers. The analyses were conducted for (a) all participants reaching an e-pBAC ≥ 0.11% (N = 986, of which 24.6% claimed to be hangover resistant) and (b) participants reaching an e-pBAC ≥ 0.18% (N = 480, of which 16.7% claimed to be hangover resistant). Results For both e-pBAC cut-off values, no significant differences between hangover sensitive and hangover resistant drinkers were found for mental resilience and wellbeing. Conclusion The current findings suggest that having a hangover is not simply an expression of poor psychological coping with the next-day consequences of heavy alcohol consumption.
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- 2018
171. Gut-brain and brain-gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet
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Perez-Pardo, Paula, Dodiya, Hemraj B., Broersen, Laus M, Douna, Hidde, van Wijk, Nick, Lopes da Silva, Sofia, Garssen, Johan, Keshavarzian, Ali, Kraneveld, Aletta D, Pharmacology, and Afd Pharmacology
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GI dysfunction ,Docosahexaenoic acid ,rotenone Parkinson's model ,uridine ,gut-brain and brain-gut axis - Abstract
Recent investigations have focused on the potential role of gastrointestinal (GI) abnormalities in the pathogenesis of Parkinson's disease (PD). The 'dual-hit' hypothesis of PD speculates that a putative pathogen enters the brain via two routes: the olfactory system and the GI system. Here, we investigated (1) whether local exposures of the neurotoxin rotenone in the gut or the brain of mice could induce PD-like neurological and GI phenotypes as well as a characteristic neuropathology in accordance with this 'dual-hit hypothesis' and (2) the effects of a diet containing uridine and fish oil providing docosahexaenoic acid (DHA), in both models. Mice were given rotenone either orally or by an injection in the striatum. Dietary interventions were started 1 week before rotenone exposures. We found that (1) both oral and intrastriatal administration of rotenone induced similar PD-like motor deficits, dopaminergic cell loss, delayed intestinal transit, inflammation, and alpha-synuclein accumulation in the colon; (2) the uridine and DHA containing diet prevented rotenone-induced motor and GI dysfunctions in both models. The models suggest possible bidirectional communication between the gut and the brain for the genesis of PD-like phenotype and pathology. The dietary intervention may provide benefits in the prevention of motor and non-motor symptoms in PD.
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- 2018
172. Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease
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Barnig, Cindy, primary, Bezema, Tjitske, additional, Calder, Philip C., additional, Charloux, Anne, additional, Frossard, Nelly, additional, Garssen, Johan, additional, Haworth, Oliver, additional, Dilevskaya, Ksenia, additional, Levi-Schaffer, Francesca, additional, Lonsdorfer, Evelyne, additional, Wauben, Marca, additional, Kraneveld, Aletta D., additional, and te Velde, Anje A., additional
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- 2019
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173. The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids
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van Sadelhoff, Joris H. J., primary, Perez Pardo, Paula, additional, Wu, Jiangbo, additional, Garssen, Johan, additional, van Bergenhenegouwen, Jeroen, additional, Hogenkamp, Astrid, additional, Hartog, Anita, additional, and Kraneveld, Aletta D., additional
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- 2019
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174. Supplementation of dietary non-digestible oligosaccharides from birth onwards improve social and reduce anxiety-like behaviour in male BALB/c mice
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Szklany, Kirsten, primary, Wopereis, Harm, additional, de Waard, Cindy, additional, van Wageningen, Thecla, additional, An, Ran, additional, van Limpt, Kees, additional, Knol, Jan, additional, Garssen, Johan, additional, Knippels, Leon M. J., additional, Belzer, Clara, additional, and Kraneveld, Aletta D., additional
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- 2019
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175. Cigarette smoke induces β2-integrin-dependent neutrophil migration across human endothelium
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Garssen Johan, Georgiou Niki A, Kamp Vera M, Kleinjan Marije, Henricks Paul A J, Braber Saskia, Overbeek Saskia A, Kraneveld Aletta D, and Folkerts Gert
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Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Cigarette smoking induces peripheral inflammatory responses in all smokers and is the major risk factor for neutrophilic lung disease such as chronic obstructive pulmonary disease. The aim of this study was to investigate the effect of cigarette smoke on neutrophil migration and on β2-integrin activation and function in neutrophilic transmigration through endothelium. Methods and results Utilizing freshly isolated human PMNs, the effect of cigarette smoke on migration and β2-integrin activation and function in neutrophilic transmigration was studied. In this report, we demonstrated that cigarette smoke extract (CSE) dose dependently induced migration of neutrophils in vitro. Moreover, CSE promoted neutrophil adherence to fibrinogen. Using functional blocking antibodies against CD11b and CD18, it was demonstrated that Mac-1 (CD11b/CD18) is responsible for the cigarette smoke-induced firm adhesion of neutrophils to fibrinogen. Furthermore, neutrophils transmigrated through endothelium by cigarette smoke due to the activation of β2-integrins, since pre-incubation of neutrophils with functional blocking antibodies against CD11b and CD18 attenuated this transmigration. Conclusion This is the first study to describe that cigarette smoke extract induces a direct migratory effect on neutrophils and that CSE is an activator of β2-integrins on the cell surface. Blocking this activation of β2-integrins might be an important target in cigarette smoke induced neutrophilic diseases.
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- 2011
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176. Transcriptional modulation of pattern recognition receptors in chronic colitis in mice is accompanied with Th1 and Th17 response
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Zheng, Bin, Morgan, Mary E, van de Kant, Hendrik J G, Garssen, Johan, Folkerts, Gert, Kraneveld, Aletta D, Sub Developmental Biology, Afd Pharmacology, Pharmacology, Sub Developmental Biology, Afd Pharmacology, and Pharmacology
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0301 basic medicine ,Biophysics ,Biochemistry ,Inflammatory bowel disease ,lcsh:Biochemistry ,03 medical and health sciences ,Immune system ,NOD2 ,Medicine ,lcsh:QD415-436 ,Colitis ,Receptor ,lcsh:QH301-705.5 ,Acute colitis ,Toll like receptors ,business.industry ,Inflammatory Bowel Disease ,FOXP3 ,medicine.disease ,digestive system diseases ,Th cell responses ,030104 developmental biology ,lcsh:Biology (General) ,TLR5 ,Immunology ,business ,Corrigendum - Abstract
Pattern recognition receptors (PRRs) may contribute to inflammatory bowel diseases (IBD) development due to their microbial-sensing ability and the unique microenvironment in the inflamed gut. In this study, the PRR mRNA expression profile together with T cell-associated factors in the colon was examined using a chronic colitis mice model. 8-12 week old C57BL/6 mice were exposed to multiple dextran sodium sulfate (DSS) treatments interspersed with a rest period to mimic the course of chronic colitis. The clinical features and histological data were collected. The mRNA expressions of colonic PRRs, T cell-associated components were measured. Finally, the colons were scored for Foxp3+ cells. During chronic colitis, the histological data, but not the clinical manifestations demonstrated characteristic inflammatory symptoms in the distal colon. In contrast to acute colitis, the expression of all Toll-like receptors (Tlrs), except Tlr5 and Tlr9, was unaffected after repeated DSS treatments. The expression of Nod1 was decreased, while Nod2 increased. After third DSS treatment, only the expressions of Tlr3 and Tlr4 were significantly enhanced. Unlike other PRRs, decreased Tlr5 and increased Tlr9 mRNA expression persisted during the chronic colitis period. As the colitis progress, only the mRNA expression of Ifnγ and Il17 staid increased during chronic colitis, while the acute colitis-associated increase of Il23, and Il10 and Il12 was abolished. Finally, increased histological score of Foxp3+ cell in colon was found during the chronic colitis period. This study provides an expression pattern of PRRs during chronic colitis that is accompanied by a Th1- and Th17 cell-mediated immune response.
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- 2017
177. Galectin-9 Produced by Intestinal Epithelial Cells Enhances Aldehyde Dehydrogenase Activity in Dendritic Cells in a PI3K- and p38-Dependent Manner
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de Kivit, Sander, Kostadinova, Atanaska I, Kerperien, JoAnn, Ayechu Muruzabal, Veronica, Morgan, Mary E, Knippels, Leon M J, Kraneveld, Aletta D, Garssen, Johan, Willemsen, Linette E M, Pharmacology, Afd Pharmacology, Pharmacology, and Afd Pharmacology
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0301 basic medicine ,Regulatory T cell ,Cellular differentiation ,Galectins ,galectin 9 ,Aldehyde dehydrogenase ,chemical and pharmacologic phenomena ,T-Lymphocytes, Regulatory ,p38 Mitogen-Activated Protein Kinases ,Interleukin 22 ,03 medical and health sciences ,Mice ,Phosphatidylinositol 3-Kinases ,0302 clinical medicine ,Intestinal mucosa ,Antigens, CD ,medicine ,otorhinolaryngologic diseases ,Immunology and Allergy ,Animals ,Humans ,dendritic cells ,Intestinal Mucosa ,Mice, Inbred BALB C ,CD40 ,biology ,Chemistry ,TLR9 ,Cell Differentiation ,Toll-like receptor 9 ,Aldehyde Dehydrogenase ,Antibodies, Neutralizing ,Cell biology ,Enzyme Activation ,Mice, Inbred C57BL ,030104 developmental biology ,medicine.anatomical_structure ,fms-Like Tyrosine Kinase 3 ,biology.protein ,Interleukin 12 ,HT29 Cells ,Integrin alpha Chains ,Intestinal epithelial cells ,030215 immunology ,Signal Transduction - Abstract
Intestinal epithelial cells (IEC) drive regulatory T cell (Treg) responses by promoting the differentiation of aldehyde dehydrogenase (ALDH)-expressing CD103+ dendritic cells (DC). Apical stimulation of TLR9 by CpG DNA on IEC supports galectin-9 expression by IEC, which is promoted by short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (GF). While galectin-9 can induce the maturation of monocyte-derived DC (moDC), the contribution of galectin-9 on the induction of ALDH activity in DC is not known. To this end, DC were stimulated with galectin-9, and ALDH activity and the expression of CD103 were assessed. ALDH activity was increased by moDC exposed to galectin-9, while the expression of CD103 remained unaltered. Galectin-9 secreted by IEC apically exposed to CpG DNA and GF enhanced ALDH activity, but not CD103 expression by moDC, which was abrogated upon galectin-9 neutralization. Similar observations were found in murine GM-CSF-cultured bone marrow-derived DC (BMDC). Using Flt3L-cultured BMDC and ex vivo murine splenic DC, it was observed that galectin-9 only enhanced ALDH activity in the presence of GM-CSF in CD103- cells. The induction of ALDH activity in BMDC was dependent on p38 and PI3K signaling. These data indicate a novel role for galectin-9 in modulating innate immunity by inducing ALDH activity in DC.
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- 2017
178. Biomarkers of the alcohol hangover state: Ethyl glucuronide (EtG) and ethyl sulfate (EtS)
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Mackus, Marlou, van de Loo, Aurora J A E, Raasveld, S. Jorinde, Hogewoning, Anna, Sastre Toraño, Javier, Flesch, Frits M, Korte-Bouws, Gerdien A H, van Neer, Renier H P, Wang, Xiaochun, Nguyen, Thomas T, Brookhuis, Karel A, Kraneveld, Aletta D, Garssen, Johan, Verster, Joris C, Afd Pharmacology, LS IRAS Tox Algemeen, Afd Chemical Biology and Drug Discovery, Pharmacology, Afd Pharmacology, LS IRAS Tox Algemeen, Afd Chemical Biology and Drug Discovery, Pharmacology, Clinical Neuropsychology, Intensive Care Medicine, and Graduate School
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Male ,urinalysis ,Hangovers ,Alcohol ,personal experience ,Urine ,sulfate ,chemistry.chemical_compound ,0302 clinical medicine ,Ethyl glucuronide ,alcohol blood level ,Medicine ,Pharmacology (medical) ,030212 general & internal medicine ,Alcohol-Related Disorders/blood ,Research Articles ,comparative study ,ETHANOL METABOLITE ,clinical article ,Sulfuric Acid Esters/urine ,medicine.diagnostic_test ,alcoholism ,Biomarkers/urine ,alcohol ,adult ,article ,HUMANS ,symptom ,Substance Withdrawal Syndrome ,unclassified drug ,Psychiatry and Mental health ,female ,Neurology ,hangover ,priority journal ,Biomarker (medicine) ,biomarker ,Blood Alcohol Content ,Female ,disease severity ,Alcohol-Related Disorders ,alcoholic beverage ,headache ,Research Article ,Adult ,medicine.medical_specialty ,Alcohol Drinking ,Adolescent ,Urinalysis ,alcohol consumption ,Glucuronates ,Sulfuric Acid Esters ,EtG ,Ethyl sulfate ,Alcohol Drinking/blood ,Substance Withdrawal Syndrome/blood ,Young Adult ,03 medical and health sciences ,male ,Internal medicine ,ethyl glucuronide ,controlled study ,human ,outcome assessment ,Glucuronates/urine ,ethyl sulfate ,EtS ,Ethanol ,business.industry ,disease association ,medicine.disease ,Endocrinology ,chemistry ,kidney concentrating capacity ,Neurology (clinical) ,ethanol ,business ,Biomarkers ,030217 neurology & neurosurgery ,urine sampling - Abstract
Introduction The aim of this study was to investigate the usefulness of ethyl glucuronide (EtG) and ethyl sulfate (EtS) as biomarkers of the hangover state.Methods Thirty-sixhealthy social drinkers participated in this study, being of naturalistic design. Eighteen participants experience regular hangovers (the hangover group), whereas the other 18 claim to not experience a hangover (the hangover-immune group). On a control day (alcohol-free) day and a post-alcohol day, urine EtG and EtS concentrations were determined and hangover severity assessed.Results Urinary EtG and EtS concentrations were significantly increased on post-alcohol day compared to the control day (p = .0001). Both EtG and EtS concentrations did not significantly correlate with the overall hangover score, nor with the estimated peak blood alcohol concentrations and number of alcoholic drinks. EtG correlated significantly only with the individual hangover symptom "headache" (p = .033; r = .403). No significant correlations were found with the EtG to EtS ratio. EtG and EtS concentrations significantly correlated with urine ethanol concentrations.Conclusions Although urine EtG and EtS concentration did not significantly correlate to estimated peak blood alcohol concentrations or the number of alcoholic drinks consumed, a significant correlation was found with urine ethanol concentration. However, urine EtG and EtS concentrations did not significantly correlate with overall hangover severity.
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- 2017
179. Role of TLR4 in the gut-brain axis in Parkinson’s disease: a translational study from men to mice
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Perez-Pardo, Paula, primary, Dodiya, Hemraj B, additional, Engen, Phillip A, additional, Forsyth, Christopher B, additional, Huschens, Andrea M, additional, Shaikh, Maliha, additional, Voigt, Robin M, additional, Naqib, Ankur, additional, Green, Stefan J, additional, Kordower, Jeffrey H, additional, Shannon, Kathleen M, additional, Garssen, Johan, additional, Kraneveld, Aletta D, additional, and Keshavarzian, Ali, additional
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- 2018
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180. l-Arginine supplementation prevents intestinal epithelial barrier breakdown under heat stress conditions by promoting nitric oxide synthesis
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Varasteh, Soheil, primary, Braber, Saskia, additional, Kraneveld, Aletta D., additional, Garssen, Johan, additional, and Fink-Gremmels, Johanna, additional
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- 2018
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181. Inflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation
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Kraneveld Aletta D, Nijkamp Frans P, Henricks Paul AJ, Braber Saskia, and Folkerts Gert
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Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Tobacco smoking irritates and damages the respiratory tract and contributes to a higher risk of developing lung emphysema. At present, smoking cessation is the only effective treatment for reducing the progression of lung emphysema, however, there is hardly anything known about the effects of smoking cessation on cytokine and chemokine levels in the airways. To the best of our knowledge, this is the first reported in vivo study in which cytokine profiles were determined after cessation of cigarette smoke exposure. Methods The severity of airway remodeling and inflammation was studied by analyzing alveolar enlargement, heart hypertrophy, inflammatory cells in the bronchoalveolar lavage fluid (BALF) and lung tissue and by determining the cytokine and chemokine profiles in the BALF of A/J mice exposed to cigarette smoke for 20 weeks and 8 weeks after smoking cessation. Results The alveolar enlargement and right ventricle heart hypertrophy found in smoke-exposed mice remained unchanged after smoking cessation. Although the neutrophilic inflammation in the BALF of cigarette smoke-exposed animals was reduced after smoking cessation, a sustained inflammation in the lung tissue was observed. The elevated cytokine (IL-1α and TNF-α) and chemokine (CCL2 and CCL3) levels in the BALF of smoke-exposed mice returned to basal levels after smoking cessation, while the increased IL-12 levels did not return to its basal level. The cigarette smoke-enhanced VEGF levels did not significantly change after smoking cessation. Moreover, IL-10 levels were reduced in the BALF of smoke-exposed mice and these levels were still significantly decreased after smoking cessation compared to the control animals. Conclusion The inflammatory changes in the airways caused by cigarette smoke exposure were only partially reversed after smoking cessation. Although smoking cessation should be the first step in reducing the progression of lung emphysema, additional medication could be provided to tackle the sustained airway inflammation.
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- 2010
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182. Hapten-induced hypersensitivity reactions in the airways: atopic versus non-atopic
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van Houwelingen, Anneke H, Kraneveld, Aletta D, and Nijkamp, Frans P
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- 2002
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183. Cigarette smoke attenuates the production of cytokines by human plasmacytoid dendritic cells and enhances the release of IL-8 in response to TLR-9 stimulation
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Mortaz Esmaeil, Lazar Zsofia, Koenderman Leo, Kraneveld Aletta D, Nijkamp Frans P, and Folkerts Gert
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Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Myeloid and plasmacytoid dendritic cells (mDCs, pDC) are crucial to the immune system, detecting microorganisms and linking the innate and adaptive immunity. pDC are present in small quantities in tissues that are in contact with the external environment; mainly the skin, the inner lining of the nose, lungs, stomach and intestines. They produce large amounts of IFN-α after stimulation and are pivotal for the induction of antiviral responses. Chronic obstructive pulmonary disease (COPD) patients are known to be more susceptible to viral infections. We have demonstrated that exposure of mDC to cigarette smoke extract (CSE) leads to the release of chemokines, however, not much is known about the role of pDC in COPD. In this study, we addressed several key questions with respect to the mechanism of action of CSE on human pDC in an in vitro model. Human pDCs were isolated from normal healthy volunteers and subjected to fresh CSE and the levels of IL-8, TNF-α, IP-10, IL-6, IL-1, IL-12 and IL-10 and IFN-α were studied by both ELISA and real time PCR methods. We observed that CSE augmented the production of IL-8 and suppressed the release of TNF-α, IL-6 and IFN-α. Moreover, CSE suppressed PI3K/Akt signalling in pDC. In conclusion, our data indicate that CSE has both the potential to diminish anti-viral immunity by downregulating the release of IFN-α and other pro-inflammatory cytokines while, at the same time, augmenting the pathogenesis of COPD via an IL-8 induced recruitment of neutrophils.
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- 2009
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184. Antibody to very late activation antigen 4 prevents interleukin-5-induced airway hyperresponsiveness and eosinophil infiltration in the airways of guinea pigs
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Kraneveld, Aletta D., Van Ark, Ingrid, Van Der Linde, Henk J., Fattah, Dilniya, Nijkamp, Frans P., and Van Oosterhout, Antoon J. M.
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- 1997
185. Role for Neurokinin-2 Receptor in Interleukin-5-induced Airway Hyperresponsiveness but not Eosinophilia in Guinea Pigs
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KRANEVELD, ALETTA D., NIJKAMP, FRANS P., and VAN OOSTERHOUT, ANTOON J. M.
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- 1997
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186. Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages
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Rahman Irfan, Kraneveld Aletta D, Karimi Khalil, Mortaz Esmaeil, Sarir Hadi, Caldenhoven Eric, Nijkamp Frans P, and Folkerts Gert
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Therapeutics. Pharmacology ,RM1-950 - Abstract
Abstract Background Toll-like receptors (TLRs) are present on monocytes and alveolar macrophages that form the first line of defense against inhaled particles. The importance of those cells in the pathophysiology of chronic obstructive pulmonary disease (COPD) has well been documented. Cigarette smoke contains high concentration of oxidants which can stimulate immune cells to produce reactive oxygen species, cytokines and chemokines. Methods In this study, we evaluated the effects of cigarette smoke medium (CSM) on TLR4 expression and interleukin (IL)-8 production by human macrophages investigating the involvement of ROS. Results and Discussion TLR4 surface expression was downregulated on short term exposure (1 h) of CSM. The downregulation could be explained by internalization of the TLR4 and the upregulation by an increase in TLR4 mRNA. IL-8 mRNA and protein were also increased by CSM. CSM stimulation increased intracellular ROS-production and decreased glutathione (GSH) levels. The modulation of TLR4 mRNA and surface receptors expression, IRAK activation, IκB-α degradation, IL-8 mRNA and protein, GSH depletion and ROS production were all prevented by antioxidants such as N-acetyl-L-cysteine (NAC). Conclusion TLR4 may be involved in the pathogenesis of lung emphysema and oxidative stress and seems to be a crucial contributor in lung inflammation.
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- 2009
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187. Recursive ensemble feature selection provides a robust mRNA expression signature for myalgic encephalomyelitis/chronic fatigue syndrome.
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Metselaar, Paula I., Mendoza-Maldonado, Lucero, Li Yim, Andrew Yung Fong, Abarkan, Ilias, Henneman, Peter, te Velde, Anje A., Schönhuth, Alexander, Bosch, Jos A., Kraneveld, Aletta D., and Lopez-Rincon, Alejandro
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MESSENGER RNA ,GENE expression ,FEATURE selection ,CHRONIC fatigue syndrome ,BIOMARKERS - Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic disorder characterized by disabling fatigue. Several studies have sought to identify diagnostic biomarkers, with varying results. Here, we innovate this process by combining both mRNA expression and DNA methylation data. We performed recursive ensemble feature selection (REFS) on publicly available mRNA expression data in peripheral blood mononuclear cells (PBMCs) of 93 ME/CFS patients and 25 healthy controls, and found a signature of 23 genes capable of distinguishing cases and controls. REFS highly outperformed other methods, with an AUC of 0.92. We validated the results on a different platform (AUC of 0.95) and in DNA methylation data obtained from four public studies on ME/CFS (99 patients and 50 controls), identifying 48 gene-associated CpGs that predicted disease status as well (AUC of 0.97). Finally, ten of the 23 genes could be interpreted in the context of the derailed immune system of ME/CFS. [ABSTRACT FROM AUTHOR]
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- 2021
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188. Classification and specific primer design for accurate detection of SARS-CoV-2 using deep learning.
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Lopez-Rincon, Alejandro, Tonda, Alberto, Mendoza-Maldonado, Lucero, Mulders, Daphne G. J. C., Molenkamp, Richard, Perez-Romero, Carmina A., Claassen, Eric, Garssen, Johan, and Kraneveld, Aletta D.
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DEEP learning ,ARTIFICIAL intelligence ,CONVOLUTIONAL neural networks ,SARS-CoV-2 ,COVID-19 pandemic - Abstract
In this paper, deep learning is coupled with explainable artificial intelligence techniques for the discovery of representative genomic sequences in SARS-CoV-2. A convolutional neural network classifier is first trained on 553 sequences from the National Genomics Data Center repository, separating the genome of different virus strains from the Coronavirus family with 98.73% accuracy. The network's behavior is then analyzed, to discover sequences used by the model to identify SARS-CoV-2, ultimately uncovering sequences exclusive to it. The discovered sequences are validated on samples from the National Center for Biotechnology Information and Global Initiative on Sharing All Influenza Data repositories, and are proven to be able to separate SARS-CoV-2 from different virus strains with near-perfect accuracy. Next, one of the sequences is selected to generate a primer set, and tested against other state-of-the-art primer sets, obtaining competitive results. Finally, the primer is synthesized and tested on patient samples (n = 6 previously tested positive), delivering a sensitivity similar to routine diagnostic methods, and 100% specificity. The proposed methodology has a substantial added value over existing methods, as it is able to both automatically identify promising primer sets for a virus from a limited amount of data, and deliver effective results in a minimal amount of time. Considering the possibility of future pandemics, these characteristics are invaluable to promptly create specific detection methods for diagnostics. [ABSTRACT FROM AUTHOR]
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- 2021
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189. Dietary, nondigestible oligosaccharides and Bifidobacterium breve M-16V suppress allergic inflammation in intestine via targeting dendritic cell maturation
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de Kivit, Sander, Kostadinova, Atanaska I, Kerperien, JoAnn, Morgan, Mary E, Muruzabal, Veronica Ayechu, Hofman, Gerard A, Knippels, Leon M J, Kraneveld, Aletta D, Garssen, Johan, Willemsen, Linette E M, Afd Pharmacology, and Pharmacology
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Mice, Inbred BALB C ,Administration, Oral ,Oligosaccharides ,Dendritic Cells ,Bifidobacterium breve ,T-Lymphocytes, Regulatory ,Cell Line ,Intestines ,Mice ,Th2 Cells ,Toll-Like Receptor 9 ,Taverne ,Journal Article ,Animals ,Female ,Food Hypersensitivity - Abstract
Dietary intervention with short-chain galacto-oligosaccharides (scGOS), long-chain fructo-oligosaccharides (lcFOS) and Bifidobacterium breve M-16V (Bb) (GF/Bb) suppresses food allergic symptoms in mice, potentially via intestinal epithelial cell (IEC)-derived galectin-9. Furthermore, in vitro studies showed galacto- and fructo-oligosaccharides (GF) to enhance the immunomodulatory capacity of a TLR9 ligand representing bacterial CpG DNA when exposed to IEC. In this study, we investigated whether GF/Bb modulates dendritic cells (DCs) and subsequent Th2 and regulatory T cell (Treg) frequency in the small intestinal lamina propria (SI-LP). BALB/c mice were fed GF/Bb during oral OVA sensitization. DC and T cell phenotype were determined in SI-LP mononuclear cells using flow cytometry. Murine bone marrow-derived DCs (BMDCs) were exposed to recombinant galectin-9 or human monocyte-derived DCs (moDCs) and were cultured in IEC-conditioned medium from GF and TLR9 ligand-exposed HT-29 cells. GF/Bb reduced allergic symptoms and enhanced serum galectin-9 levels, while suppressing activation, restoring phagocytic capacity, and normalizing CD103 expression of SI-LP DCs of OVA-allergic mice. In vitro, galectin-9 suppressed LPS-induced activation markers and cytokine secretion by BMDCs, and IEC-conditioned medium suppressed moDC activation in a galectin-9-dependent manner. Besides suppression of SI-LP DC activation, dietary GF/Bb also lowered the frequency of activated Th2 cells, while enhancing Treg in the SI-LP of OVA-allergic mice compared to the control diet. Dietary intervention with GF/Bb enhances galectin-9 and suppresses allergic symptoms of OVA-allergic mice in association with reduced intestinal DC and Th2 activation and increased Treg frequency in these mice.
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- 2017
190. Promising effects of neurorestorative diets on motor, cognitive, and gastrointestinal dysfunction after symptom development in a mouse model of Parkinson's disease
- Author
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Perez-Pardo, Paula, de Jong, Esther M, Broersen, Laus M, van Wijk, Nick, Attali, Amos, Garssen, Johan, Kraneveld, Aletta D, Afd Pharmacology, Pharmacology, Afd Pharmacology, and Pharmacology
- Subjects
0301 basic medicine ,Aging ,Parkinson's disease ,motor-symptoms ,Cognitive Neuroscience ,medicine.medical_treatment ,Disease ,Striatum ,Pharmacology ,Biology ,Synapse ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,medicine ,Rotenone Parkinson's model ,Original Research ,Prebiotic ,Dopaminergic ,Rotenone ,docosahexaenoic acid ,medicine.disease ,non-motor symptoms ,030104 developmental biology ,chemistry ,Docosahexaenoic acid ,uridine ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic nigrostriatal neurons, with reductions in the function and amount of dopaminergic synapses. Therefore, synapse loss and membrane-related pathology provide relevant targets for interventions in PD. We previously showed the beneficial preventive effects of a dietary intervention containing uridine and DHA, two precursors for membrane synthesis, in the intrastriatal rotenone model for PD. Here, we examined the therapeutic potential of the same dietary intervention on motor, cognitive, and gastrointestinal symptoms. In addition, we tested the effects of an extended nutritional formula based on the same precursors plus other nutrients that increase membrane phospholipid synthesis as well as prebiotic fibers. C57BL/6J mice received a unilateral rotenone injection in the striatum. Dietary interventions started 28 days after surgery, when motor-symptoms had developed. Readout parameters included behavioral tasks measuring motor function and spatial memory as well as intestinal function and histological examination of brain and gut to assess PD-like pathology. Our results show that rotenone-induced motor and non-motor problems were partially alleviated by the therapeutic dietary interventions providing uridine and DHA. The extended nutritional intervention containing both precursors and other nutrients that increase phospholipid synthesis as well as prebiotic fibers was more effective in normalizing rotenone-induced motor and non-motor abnormalities. The latter diet also restored striatal DAT levels, indicating its neurorestorative properties. This is the first study demonstrating beneficial effects of specific dietary interventions, given after full development of symptoms, on a broad spectrum of motor and non-motor symptoms in a mouse model for PD.
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- 2017
191. Exploring Braak’s Hypothesis of Parkinson’s Disease
- Author
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Rietdijk, Carmen D, Perez-Pardo, Paula, Garssen, Johan, van Wezel, Richard J A, Kraneveld, Aletta D, Afd Pharmacology, Pharmacology, Afd Pharmacology, and Pharmacology
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0301 basic medicine ,Pathology ,medicine.medical_specialty ,Parkinson's disease ,ASynuclein ,Central nervous system ,Biophysics ,Disease ,Review ,Biology ,Braak's hypothesis ,03 medical and health sciences ,chemistry.chemical_compound ,Lewy pathology ,0302 clinical medicine ,enteric nervous system ,mental disorders ,medicine ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,Nose ,Alpha-synuclein ,αSynuclein ,Braak’s hypothesis ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Neurology ,Parkinson’s disease ,Digestive tract ,Enteric nervous system ,Neurology (clinical) ,030217 neurology & neurosurgery ,Neuroscience - Abstract
Parkinson's disease (PD) is a neurodegenerative disorder for which there is no cure. Most patients suffer from sporadic PD, which is likely caused by a combination of genetic and environmental factors. Braak's hypothesis states that sporadic PD is caused by a pathogen that enters the body via the nasal cavity, and subsequently is swallowed and reaches the gut, initiating Lewy pathology (LP) in the nose and the digestive tract. A staging system describing the spread of LP from the peripheral to the central nervous system was also postulated by the same research group. There has been criticism to Braak's hypothesis, in part because not all patients follow the proposed staging system. Here, we review literature that either supports or criticizes Braak's hypothesis, focused on the enteric route, digestive problems in patients, the spread of LP on a tissue and a cellular level, and the toxicity of the protein αSynuclein (αSyn), which is the major constituent of LP. We conclude that Braak's hypothesis is supported by in vitro, in vivo, and clinical evidence. However, we also conclude that the staging system of Braak only describes a specific subset of patients with young onset and long duration of the disease.
- Published
- 2017
192. Microbes Tickling Your Tummy: the Importance of the Gut-Brain Axis in Parkinson's Disease
- Author
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Perez-Pardo, Paula, Hartog, Mitch, Garssen, Johan, Kraneveld, Aletta D, Afd Pharmacology, LS IRAS Tox Algemeen, and Pharmacology
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inflammation ,Parkinson's disease ,alpha-Synuclein ,gut microbiotica ,Gastrointestinal dysfunction - Abstract
Purpose of Review: Patients suffering from Parkinson's disease (PD) are known to experience gastrointestinal dysfunction that might precede the onset of motor symptoms by several years. Evidence suggests an important role of the gut-brain axis in PD pathogenesis. These interactions might be essentially influenced by the gut microbiota. Here, we review recent findings supporting that changes in the gut microbiota composition might be a trigger for inflammation contributing to neurodegeneration in PD. Recent Findings: Recent research revealed that PD patients exhibit a pro-inflammatory microbiota profile in their intestinal tract that might increase gut permeability, allowing leakage of bacterial products and inflammatory mediators from the intestines. Evidence in literature indicates that alpha-synuclein deposition might start in the enteric nervous system by pro-inflammatory immune activity and then propagates to the CNS. Alternatively, the peripheral inflammatory response could impact the brain through systemic mechanisms. Summary: A better understanding of the gut-brain interactions and the role of the intestinal microbiota in the regulation of immune responses might bring new insights in PD pathological progression and might lead to novel diagnostics and therapeutic approaches.
- Published
- 2017
193. Lipoproteins attenuate TLR2 and TLR4 activation by bacteria and bacterial ligands with differences in affinity and kinetics
- Author
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van Bergenhenegouwen, Jeroen, Kraneveld, Aletta D, Rutten, Lieke, Garssen, Johan, Vos, Arjan P, Hartog, Anita, Sub General Pharmacology, Sub Interdisciplinary translational Phar, Sub Immunopharmacology, Pharmacology, Sub General Pharmacology, Sub Interdisciplinary translational Phar, Sub Immunopharmacology, and Pharmacology
- Subjects
0301 basic medicine ,Salmonella typhimurium ,Staphylococcus aureus ,Immunology ,Lipoproteins, VLDL ,Lymphocyte Activation ,03 medical and health sciences ,Immune system ,Antigen ,medicine ,Humans ,Antigens, Bacterial ,biology ,biology.organism_classification ,Mucus ,Small intestine ,Toll-Like Receptor 2 ,Lipoproteins, LDL ,Toll-Like Receptor 4 ,TLR2 ,030104 developmental biology ,medicine.anatomical_structure ,Apolipoproteins ,HEK293 Cells ,Biochemistry ,TLR4 ,Leukocytes, Mononuclear ,Cytokines ,lipids (amino acids, peptides, and proteins) ,Immunization ,Lipoproteins, HDL ,Bacteria ,Lipoprotein ,Research Article - Abstract
Background The small intestine is a specialized compartment were close interactions take place between host, microbes, food antigens and dietary fatty acids. Dietary fats get absorbed by epithelial cells and processed into a range of lipoprotein particles after which they are basolaterally secreted and collected in the lymphatics. In contrast to the colon, the small intestine is covered only by a thin mucus coat that allows for intimate interactions between host-cells and microbes. Lipoproteins have long been recognized as protective factors in infectious diseases via the neutralization of bacterial toxins like lipopolysaccharides. Much less attention has been given to the potential role of lipoproteins as factors contributing to the maintenance of small intestinal immune homeostasis via modulating bacteria-induced immune responses. Results Lipoproteins VLDL, LDL and HDL were found to neutralize TLR responses towards specific TLR-ligands or a selection of gram-negative and gram-positive bacteria. Attenuation of TLR2 activity was acute and only slightly improved by longer pre-incubation times of ligands and lipoproteins with no differences between bacterial-lipopeptides or bacteria. In contrast, attenuation of TLR4 responses was only observed after extensive preincubation of lipoproteins and LPS. Preincubation of bacteria and lipoproteins led only to a modest attenuation of TLR4 activity. Moreover, compared to TLR2, TLR4 activity could only be attenuated by lipoproteins over a small ligand dose range. Conclusions These results demonstrate the ability of lipoproteins VLDL, LDL and HDL to inhibit TLR responses towards bacterial-ligands and bacteria. Presence of lipoproteins was found to modulate the MAMP-induced cytokine release by primary human monocytes measured as changes in the release of IL-6, TNFα, GM-CSF and IFNγ. Using TLR2 and TLR4-reporter cells, lipoproteins were found to inhibit TLR responses with differences in affinity and kinetics. These data establish a role for lipoproteins as immunoregulatory molecules, attenuating TLR-responses and thereby positively contributing to mucosal homeostasis. Electronic supplementary material The online version of this article (doi:10.1186/s12865-016-0180-x) contains supplementary material, which is available to authorized users.
- Published
- 2016
194. Excitatory non-adrenergic–non-cholinergic neuropeptides: key players in asthma
- Author
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Kraneveld, Aletta D, James, Deborah E, de Vries, Annick, and Nijkamp, Frans P
- Published
- 2000
- Full Text
- View/download PDF
195. Is nutrition science ready for the twenty-first century? Moving towards transdisciplinary impacts in a changing world.
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Tufford, Adèle R., Calder, Philip C., Van't Veer, Pieter, Feskens, Edith F., Ockhuizen, Theo, Kraneveld, Aletta D., Sikkema, Jan, and de Vries, Jan
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MALNUTRITION ,COMMUNICATION ,CONFERENCES & conventions ,DIET ,DIFFUSION of innovations ,FOOD habits ,NUTRITION ,ADULT education workshops ,FOOD science ,DISEASE risk factors - Abstract
Malnutrition in an obese world was the fitting title of the 13th Federation of European Nutrition Societies (FENS) conference held in October 2019. Many individuals do not eat a healthy, well-balanced diet, and this is now understood to be a major driver of increased disease risk and illness. Moreover, both our current eating patterns and the food system as a whole are environmentally unsustainable, threatening the planetary systems we depend on for survival. As we attempt to feed a growing global population, food systems will increasingly be confronted with their environmental impacts, with the added challenge of climate change-induced threats to food production. As we move into the third decade of the twenty-first century, these challenges demand that the nutrition research community reconsider its scope, concepts, methods, and societal role. At a pre-meeting workshop held at the FENS conference, over 70 researchers active in the field explored ways to advance the discipline's capacity to address cross-cutting issues of personal, public and planetary health. Using the world cafe method, four themed discussion tables explored (a) the breadth of scientific domains needed to meet the current challenges, (b) the nature and definition of the shifting concepts in nutrition sciences, (c) the next-generation methods required and (d) communication and organisational challenges and opportunities. As a follow-up to earlier work [1], here we report the highlights of the discussions, and propose the next steps to advance responsible research and innovation in the domain of nutritional science. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
196. Omics for the future in asthma.
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Abdel-Aziz, Mahmoud I., Neerincx, Anne H., Vijverberg, Susanne J., Kraneveld, Aletta D., and Maitland-van der Zee, Anke H.
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MORPHOLOGY ,ASTHMA ,INDIVIDUALIZED medicine ,RESEARCH teams ,ASTHMATICS - Abstract
Asthma is a common, complex, multifaceted disease. It comprises multiple phenotypes, which might benefit from treatment with different types of innovative targeted therapies. Refining these phenotypes and understanding their underlying biological structure would help to apply precision medicine approaches. Using different omics methods, such as (epi)genomics, transcriptomics, proteomics, metabolomics, microbiomics, and exposomics, allowed to view and investigate asthma from diverse angles. Technological advancement led to a large increase in the application of omics studies in the asthma field. Although the use of omics technologies has reduced the gap between bench to bedside, several design and methodological challenges still need to be tackled before omics can be applied in asthma patient care. Collaborating under a centralized harmonized work frame (such as in consortia, under consistent methodologies) could help worldwide research teams to tackle these challenges. In this review, we discuss the transition of single biomarker research to multi-omics studies. In addition, we deliberate challenges such as the lack of standardization of sampling and analytical methodologies and validation of findings, which comes in between omics and personalized patient care. The future of omics in asthma is encouraging but not completely clear with some unanswered questions, which have not been adequately addressed before. Therefore, we highlight these questions and emphasize on the importance of fulfilling them. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
197. Towards "Improved Standards in the Science of Nutrition" through the Establishment of Federation of European Nutrition Societies Working Groups.
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Calder, Philip C., Feskens, Edith J.M., Kraneveld, Aletta D., Plat, Jogchum, van 't Veer, Pieter, and de Vries, Jan
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COMMITTEES ,COMMUNICATION ,ENDOWMENT of research ,RESEARCH methodology ,NONPROFIT organizations ,NUTRITION ,NUTRITIONAL requirements ,PROFESSIONAL associations ,RESPONSIBILITY ,TRUST ,MEMBERSHIP - Abstract
The article discusses a proposal by the Federation of European Nutrition Societies (FENS) to establish three working groups with an aim of improving standards in the science of nutrition.
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- 2020
- Full Text
- View/download PDF
198. Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson’s Disease
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Perez-Pardo, Paula, primary, Broersen, Laus M., additional, Kliest, Tessa, additional, van Wijk, Nick, additional, Attali, Amos, additional, Garssen, Johan, additional, and Kraneveld, Aletta D., additional
- Published
- 2018
- Full Text
- View/download PDF
199. The Potential Biomarkers and Immunological Effects of Tumor-Derived Exosomes in Lung Cancer
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Alipoor, Shamila D., primary, Mortaz, Esmaeil, additional, Varahram, Mohammad, additional, Movassaghi, Mehrnaz, additional, Kraneveld, Aletta D., additional, Garssen, Johan, additional, and Adcock, Ian M., additional
- Published
- 2018
- Full Text
- View/download PDF
200. Susceptibility to Alcohol Hangovers: Not Just a Matter of Being Resilient
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van Schrojenstein Lantman, Marith, primary, van de Loo, Aurora J A E, additional, Mackus, Marlou, additional, Kraneveld, Aletta D, additional, Brookhuis, Karel A, additional, Garssen, Johan, additional, and Verster, Joris C, additional
- Published
- 2017
- Full Text
- View/download PDF
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