Search

Your search keyword '"L., Biancone"' showing total 641 results
Start Over Author "L., Biancone"
641 results on '"L., Biancone"'

152. P.1.314: FISTULIZING PATTERN AND YOUNG AGE AT THE DIAGNOSIS AS RISK FACTORS FOR CANCER MORE RELEVANT THAN IMMUNOMODULATORS IN CROHN'S DISEASE: A SINGLECENTER COHORT STUDY IN 1288 PATIENTS

Author

Carla Rossi, S. Zuzzi, Carmelina Petruzziello, Giovanna Condino, Francesca Zorzi, M. Ranieri, Sara Onali, Francesco Pallone, Emma Calabrese, Marta Ascolani, and L. Biancone

Subjects
medicine.medical_specialty, Crohn's disease, Hepatology, business.industry, Gastroenterology, Cancer, Retrospective cohort study, medicine.disease, Young age, Internal medicine, medicine, business, Prospective cohort study, Cohort study
Published
2011
Full Text
View/download PDF

154. Spontaneous cytotoxicity of intestinal intraepithelial lymphocytes: clues to the mechanism

Author

L Biancone, Robert E. Brolin, Arthur I. Roberts, Ellen C. Ebert, and S M O'Connell

Subjects
Cytotoxicity, Immunologic, Lymphocyte, CD3, Immunology, chemical and pharmacologic phenomena, CD16, digestive system, Antigens, CD, Tumor Cells, Cultured, medicine, Humans, Immunology and Allergy, Cytotoxic T cell, Lymphocytes, Intestinal Mucosa, Cytotoxicity, Antibody-dependent cell-mediated cytotoxicity, biology, Receptors, IgG, Antibody-Dependent Cell Cytotoxicity, hemic and immune systems, Flow Cytometry, Killer Cells, Natural, Jejunum, medicine.anatomical_structure, biology.protein, Intraepithelial lymphocyte, tissues, CD8, Research Article
Abstract

SUMMARYHuman intestinal intraepithelial lymphocytes (IEL) demonstrate target cell-restricted spontaneous cytotoxic (SC) activity that is due to CD2+CD3+CD8+CD16−CD56– effector eells: they kill epithelial cell (EC) tumours (such as DLD-1 colon cancer eells), but not natural killer (NK)-sensitive K-562 cells. The present study shows that the measured levels of SC activities by IEL correlated with those of autologous lamina propria lymphocytes (LPL), but not with those of peripheral blood lymphocytes (PBL). Also, the susceptibilities of DLD-1 cell clones to lysis by IEL and PBL effector cells did not correlate, suggesting different mechanisms of lysis. Antibody blocking experiments showed that the main surface molecules involved in lysis depended on the effector cell type: αEβt (HML-l) on IEL and CDI6 on PBL. No antibody-dependent cell-mediated cytotoxicity (ADCC) was demonstrated by IEL, even after stimulation with inerferon-gamma (IFN-γ). Few IEL expressed Fc receptors for IgG. This study describes further differences between the SC activities of IEL and PBL.

Published
1993

155. P.174 DIAGNOSTIC ROLE OF CAPSULE ENDOSCOPY IN PATIENTS WITH SYMPTOMS HIGHLY COMPATIBLE WITH CROHN'S DISEASE

Author

L. Biancone, Giovanna Condino, Francesco Pallone, Emma Calabrese, Carmelina Petruzziello, Elisabetta Lolli, Marta Ascolani, Sara Onali, and Francesca Zorzi

Subjects
medicine.medical_specialty, Crohn's disease, Hepatology, biology, business.industry, Firmicutes, Gastroenterology, Horse, Urine, medicine.disease, biology.organism_classification, Ulcerative colitis, Inflammatory bowel disease, Internal medicine, medicine, Clinical significance, business, Feces
Abstract

Background: Resident colonic bacteria, principally anaerobes and firmicutes, ferment undigested fibre, leading to the formation of volatile organic compounds (VOC). These are passed in faeces but also possibly absorbed and excreted in the urine. We hypothesised that the “fermentation profile” (FP), as seen in faeces and urine, may differ in health and in inflammatory bowel disease (IBD), and in the latter may change as the patient responds to treatment. Aim: Pilot study to determine if FP in faeces and urine can be recognised and reliably measured and to examine if there were identifiable differences in health and IBD. Methods: Healthy volunteers n=2; Longitudinal study of IBD patients: ulcerative colitis (UC) n=1, studied when acutely ill and when better on treatment; Crohn's disease (CD) n=1, at the beginning and during the course of Infliximab therapy. Samples of faeces and urine were analysed fresh and after storage for 2 weeks. VOC were released by heating (thermal desorption, TD) separated by gas chromatography (GC) and identified by mass spectroscopy (MS). The noise in GC data was cleaned using Clearview software ©Markes. Results: Initial technical developments were made using horse, cow and chicken faeces: each showed a very large number of peaks, some shared. Volunteers within-run variability

Published
2010
Full Text
View/download PDF

156. P.80 INFLIXIMAB FOR SEVERE ULCERATIVE COLITIS: SHORT-TERM AND ONE YEAR OUTCOME OF THREE DOSE REGIMEN. AN ITALIAN MULTICENTRE OPEN-LABEL STUDY

Author

Annalisa Aratari, M.L. Guidi, Gabriele Riegler, L. Biancone, G. Meucci, Alessandro Lavagna, Alessandro Gasbarrini, Claudio Papi, Carmelina Petruzziello, Marco Daperno, V. F. Annese, A. Orlando, Cosimo Prantera, Angelo Viscido, R. Sostegni, Anna Kohn, Maria Cappello, R. Monterubbianesi, A. Armuzzi, and S. Peralta

Subjects
medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, medicine.disease, Outcome (game theory), Ulcerative colitis, Infliximab, Term (time), Regimen, Open label study, Internal medicine, medicine, business, medicine.drug
Published
2010
Full Text
View/download PDF

157. P.95 DEVELOPMENT OF COLONIC METAPLASIA IN THE NEO-TERMINAL ILEUM OF CROHN'S DISEASE PATIENTS AFTER ILEO-COLONIC RESECTION AND RECURRENCE: A PROSPECTIVE LONGITUDINAL STUDY

Author

Francesco Pallone, L. Biancone, Massimo Rugge, Vanni Lazzarin, C. Mescoli, Sara Onali, Carmelina Petruzziello, G. Palmieri, Giuseppe S. Sica, Marta Ascolani, and Francesca Zorzi

Subjects
Longitudinal study, medicine.medical_specialty, Crohn's disease, Hepatology, business.industry, Colonic resection, Gastroenterology, medicine.disease, medicine.anatomical_structure, Metaplasia, Internal medicine, Terminal ileum, Medicine, medicine.symptom, business
Published
2010
Full Text
View/download PDF

158. P.84 OUTCOME OF PATIENTS WITH MODERATE-SEVERE ULCERATIVE COLITIS: A LONGITUDINAL STUDY IN PATIENTS UNDER REGULAR FOLLOW-UP

Author

Francesca Zorzi, Giovanna Condino, L. Biancone, Sara Onali, Giuseppe S. Sica, Carmelina Petruzziello, Francesco Pallone, Emma Calabrese, and Elisabetta Lolli

Subjects
medicine.medical_specialty, Longitudinal study, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, In patient, medicine.disease, business, Ulcerative colitis, Outcome (game theory)
Published
2010
Full Text
View/download PDF

159. P.195 CONTRAST ENHANCED ENDOSCOPIC ULTRASOSONOGRAPHY (CE-AEUS) FOR ASSESSING PERIANAL DISEASE: PRELIMINARY STUDY

Author

L. Biancone, Francesco Pallone, Emma Calabrese, A. Caruso, Pierpaolo Sileri, Sara Onali, G. Del Vecchio Blanco, Achille L. Gaspari, and Carmelina Petruzziello

Subjects
medicine.medical_specialty, Hepatology, business.industry, media_common.quotation_subject, Gastroenterology, Medicine, Contrast (vision), Perianal disease, Radiology, business, media_common
Published
2010
Full Text
View/download PDF

160. P.77 BIOLOGIC THERAPIES, THIOPURINES AND CANCER IN INFLAMMATORY BOWEL DISEASE: A SINGLE-CENTER COHORT STUDY IN 1118 PATIENTS

Author

Elisabetta Lolli, Giuseppe S. Sica, Francesco Pallone, S. Zuzzi, M. Ranieri, Carmelina Petruzziello, Francesca Zorzi, Sara Onali, Marta Ascolani, Elisa Stasi, and L. Biancone

Subjects
Oncology, medicine.medical_specialty, Hepatology, business.industry, Biologic therapies, Gastroenterology, Cancer, medicine.disease, Single Center, Inflammatory bowel disease, Internal medicine, medicine, business, Cohort study
Published
2010
Full Text
View/download PDF

162. BIOLOGIC THERAPIES AND SUB-OBSTRUCTIVE SYMPTOMS IN CROHN'S DISEASE: PROSPECTIVE LONGITUDINAL STUDY

Author

Sara Onali, Francesco Pallone, Francesca Zorzi, Elisabetta Lolli, Emma Calabrese, Giovanna Condino, P. Naccarato, Carmelina Petruzziello, and L. Biancone

Subjects
Longitudinal study, Crohn's disease, medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Biologic therapies, Gastroenterology, Medicine, business, medicine.disease
Published
2009
Full Text
View/download PDF

164. EVOLUTION OF THE LESIONS RELATED TO CROHN'S DISEASE RECURRENCE AS ASSESSED BY ULTRA-SONOGRAPHY: A PROSPECTIVE LONGITUDINAL STUDY

Author

Sara Onali, Giovanna Condino, L. Biancone, Carmelina Petruzziello, Francesco Pallone, Elisabetta Lolli, Emma Calabrese, Francesca Zorzi, and P. Naccarato

Subjects
Longitudinal study, medicine.medical_specialty, Crohn's disease, Hepatology, business.industry, Ultra sonography, Gastroenterology, Medicine, business, medicine.disease, Surgery
Published
2009
Full Text
View/download PDF

166. CT-ENTEROGRAPHY VS SMALL INTESTINE CONTRAST ULTRASONOGRAPHY IN ASSESSING ILEAL LESIONS IN CROHN'S DISEASE: A PROSPECTIVE LONGITUDINAL STUDY IN PATIENTS UNDERGOING SURGERY

Author

L. Biancone, Francesco Pallone, G. Palmieri, Emma Calabrese, Sara Onali, Elisabetta Lolli, Roberto Fiori, Carmelina Petruzziello, Giuseppe S. Sica, Giovanna Condino, and S. Vanni

Subjects
medicine.medical_specialty, Crohn's disease, Longitudinal study, Hepatology, CT enterography, business.industry, media_common.quotation_subject, Gastroenterology, medicine.disease, Small intestine, medicine.anatomical_structure, Medicine, Contrast (vision), In patient, Radiology, Ultrasonography, business, media_common
Published
2009
Full Text
View/download PDF

167. SMALL INTESTINE CONTRAST ULTRASONOGRAPHY FOR DETECTING ASYMPTOMATIC SMALL BOWEL CROHN'S DISEASE LESIONS: A FAMILY STUDY

Author

Sara Onali, Carmelina Petruzziello, Francesca Zorzi, Francesco Pallone, Emma Calabrese, L. Biancone, Giovanna Condino, and Elisabetta Lolli

Subjects
medicine.medical_specialty, Crohn's disease, Hepatology, business.industry, media_common.quotation_subject, Gastroenterology, medicine.disease, Asymptomatic, Small intestine, medicine.anatomical_structure, Internal medicine, medicine, Contrast (vision), Radiology, medicine.symptom, Ultrasonography, business, media_common
Published
2009
Full Text
View/download PDF

169. COLORECTAL CANCER SCREENING BY COLONOSCOPY: EXPERIENCE IN HIGH AND LOW RISK POPULATION

Author

M. Cretella, I. Stroppa, Francesco Pallone, Omero Alessandro Paoluzi, A. Caruso, Pierpaolo Sileri, M. Giannelli, G. Del Vecchio Blanco, G. Palmieri, F. Servadei, L. Biancone, Raffaella Lionetti, and E. Grasso

Subjects
Oncology, medicine.medical_specialty, Hepatology, Low risk population, medicine.diagnostic_test, business.industry, Colorectal cancer screening, Internal medicine, Gastroenterology, Medicine, Colonoscopy, business
Published
2009
Full Text
View/download PDF

170. ROLE OF SMALL INTESTINE CONTRAST ULTRASONOGRAPHY IN CELIAC DISEASE

Author

A. Caruso, Carmelina Petruzziello, Francesco Pallone, Emma Calabrese, M. Cossignani, Sara Onali, L. Biancone, and G. Del Vecchio Blanco

Subjects
medicine.medical_specialty, Hepatology, business.industry, media_common.quotation_subject, Gastroenterology, Disease, Small intestine, medicine.anatomical_structure, Internal medicine, medicine, Contrast (vision), Ultrasonography, business, media_common
Published
2009
Full Text
View/download PDF

171. The presence in experimental animals of a colon specific Mr 40,000 protein(s) with relevance to ulcerative colitis

Author

K M Das, L Biancone, and L S Wise

Subjects
Pathology, medicine.medical_specialty, Colon, Immunocytochemistry, Enzyme-Linked Immunosorbent Assay, Mice, Inbred Strains, Cross Reactions, Autoantigens, Protein S, Epitope, Epitopes, Mice, Species Specificity, medicine, Animals, Humans, biology, Gastroenterology, Rats, Inbred Strains, medicine.disease, Ulcerative colitis, Isotype, Small intestine, Epithelium, digestive system diseases, Rats, medicine.anatomical_structure, biology.protein, Colitis, Ulcerative, Antibody, Research Article
Abstract

In patients with ulcerative colitis a colon tissue bound IgG and serum antibodies against an Mr 40,000 colonic protein(s) has been identified. Using an anti-Mr 40,000 protein monoclonal antibody, 7E12H12, by an immunocytochemical method, the protein was localised in human tissue exclusively to colonic epithelial cells. In this study the presence of the Mr 40,000 protein was assessed in experimental animals by the direct and inhibition enzyme linked immunosorbent assays (ELISAs) using the anti-Mr 40,000 protein monoclonal antibody, 7E12H12 (IgM isotype). In addition, a total of 129 specimens including colon, small intestine, gall bladder, biliary tract, and kidney from nine strains of rats and mice, and from human tissue were studied by the immunocytochemical method using 7E12H12. All colon specimens from both humans and animals reacted with 7E12H12 in the immunocytochemical and ELISA assays. None of the non-colonic organs reacted with 7E12H12. While in human colon 7E12H12 recognised the absorptive epithelial cells, in all the animals it recognised mainly the colonic goblet cells. Extracts of animal colon but not of small intestine inhibited the binding of 7E12H12 to the human colon extract. This study shows the presence of an organ specific Mr 40,000 colonic epithelial protein(s) in humans and experimental animals. A differing cellular localisation of the Mr 40,000 protein(s) in human v animal tissue was also shown. Further characterisation of the Mr 40,000 protein(s) may provide important clues regarding the autoimmune mechanisms in ulcerative colitis.

Published
1991

172. Serum immunomodulatory factors in gastrointestinal diseases. A 30-50-kD serum fraction in Crohn's disease capable of modulating lymphocyte activation

Author

Monica Boirivant, L. Biancone, Francesco Pallone, Roberto Paganelli, G. L. Ricci, and Stefano Fais

Subjects
Interleukin 2, Adult, Male, medicine.medical_specialty, Lymphocyte, Immunology, Transferrin receptor, Fusion Regulatory Protein-1, Lymphocyte Activation, Antigen, Crohn Disease, Internal medicine, Receptors, Transferrin, medicine, Suppressor Factors, Immunologic, Immunology and Allergy, Humans, Phytohemagglutinins, Receptor, Crohn's disease, Cell growth, business.industry, Receptors, Interleukin-2, Middle Aged, medicine.disease, Antigens, Differentiation, Kinetics, Endocrinology, medicine.anatomical_structure, Cell culture, Antigens, Surface, Female, business, medicine.drug, Research Article
Abstract

SUMMARY We tested the hypothesis that serum factors present in Crohn's disease interfere with the process of lymphocyte activation. The mitogen-induced proliferation and the expression of early activation antigens by normal lymphocytes cultured in the presence of either Crohn's disease sera or sera from different controls were evaluated. The mitogen-induced proliferation was significantly impaired in the presence of Crohn's disease sera. These sera markedly inhibited the mitogen-induced interleukin-2 receptor (IL-2R) expression (48% inhibition), while the effect of sera on the expression of the transferrin receptor and the 4F2 antigen was much less pronounced. Diafiltration experiments showed that the inhibitory effect was confined to a 30–50-kD serum fraction. Such a serum property was not related to the patients' disease activity and disappeared after surgical removal of the affected bowel. The capability of inhibiting the mitogen-induced IL-2R expression was not restricted to Crohn's disease and was observed with sera from other inflammatory and neoplastic gastrointestinal disorders. This study indicates that a marked inhibition of the IL-2R is a mechanism underlying the immunosuppressive property of the serum in Crohn's disease and in other gastrointestinal conditions.

Published
1991

173. 36. Comparison between 99mTc-IL2 and 99mTc-HMPAO granulocyte scintigraphy in Crohnʼs disease

Author

Alberto Signore, L. Biancone, M. Rossi, S. J. Mather, M. G. Parisella, R. Caviglia, Marco Chianelli, M. B. Stochino, and A. Annovazzi

Subjects
medicine.anatomical_structure, medicine.diagnostic_test, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Disease, Granulocyte, business, Scintigraphy, Nuclear medicine, 99mTc-HMPAO
Published
1999
Full Text
View/download PDF

174. PA.119 COLORECTAL CANCER SCREENING: ARE WE DOING ENOUGH? ONE YEAR SINGLE CENTER EXPERIENCE IN HIGH AND LOW RISK POPULATION

Author

G. Palmieri, E. Grasso, Francesco Pallone, A. Alvino, D. Liotti, E. Mannisi, M. Cretella, I. Stroppa, G. Del Vecchio Blanco, Leonardo Baiocchi, M. Giannelli, Omero Alessandro Paoluzi, Pierpaolo Sileri, L. Biancone, Raffaella Lionetti, and A. Caruso

Subjects
Oncology, medicine.medical_specialty, Hepatology, Low risk population, business.industry, Colorectal cancer screening, Internal medicine, Gastroenterology, Medicine, business, Single Center
Published
2008
Full Text
View/download PDF

175. PA.163 SMALL INTESTINE CONTRAST ULTRASONOGRAPHY (SICUS) FOR DETECTING ASYMPTOMATIC SMALL BOWEL CROHN'S DISEASE: A FAMILY STUDY

Author

L. Biancone, Sara Onali, Francesco Pallone, Emma Calabrese, S. Ooka, Carmelina Petruzziello, Francesca Zorzi, and Giovanna Condino

Subjects
medicine.medical_specialty, Crohn's disease, Sicus, Hepatology, biology, business.industry, media_common.quotation_subject, Gastroenterology, biology.organism_classification, medicine.disease, Asymptomatic, Small intestine, medicine.anatomical_structure, Internal medicine, medicine, Contrast (vision), Ultrasonography, medicine.symptom, business, media_common
Published
2008
Full Text
View/download PDF

176. PA.164 CAPSULE ENDOSCOPY (CE) AND PROXIMAL SMALL BOWEL (SB) LESIONS IN PATIENTS WITH CROHN'S DISEASE (CD)

Author

L. Biancone, Sara Onali, G. Del Vecchio Blanco, Giovanna Condino, Francesco Pallone, Emma Calabrese, Francesca Zorzi, and Carmelina Petruzziello

Subjects
medicine.medical_specialty, Crohn's disease, Hepatology, business.industry, Gastroenterology, medicine.disease, law.invention, Capsule endoscopy, law, Internal medicine, medicine, In patient, business
Published
2008
Full Text
View/download PDF

177. P157 COMPARISON BETWEEN TECHNIQUES PROVIDING A DIFFERENT VIEW OF THE PERI-ANASTOMOTIC AREA (LUMINAL VS EXTRALUMINAL) IN ASSESSING CROHN'S DISEASE RECURRENCE: A PROSPECTIVE LONGITUDINAL STUDY

Author

Francesca Zorzi, L. Biancone, Sara Onali, Francesco Pallone, Emma Calabrese, Giovanna Condino, G.S. Sica, and Carmelina Petruzziello

Subjects
medicine.medical_specialty, Longitudinal study, Crohn's disease, business.industry, Peri, Medicine, Anastomosis, business, medicine.disease, Surgery
Published
2008
Full Text
View/download PDF

178. P117 PERIANAL CROHN'S DISEASE ASSESSMENT: MAGNETIC RESONANCE IMAGING, ENDOSCOPIC ULTRASOUND, EXAMINATION UNDER ANAESTHESIA

Author

L. Biancone, Gme Simonetti, Achille L. Gaspari, Valeria Fiaschetti, Pierpaolo Sileri, Sara Onali, Francesco Pallone, Carmelina Petruzziello, Emma Calabrese, G. Del Vecchio Blanco, and G.S. Sica

Subjects
Endoscopic ultrasound, Perianal Crohn's disease, medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine, Examination under anaesthesia, Magnetic resonance imaging, Radiology, business
Published
2008
Full Text
View/download PDF

180. P051 WIRELESS CAPSULE ENDOSCOPY VERSUS SMALL INTESTINE CONTRAST ULTRASONOGRAPHY FOR ASSESSING THE POSTOPERTIVE RECURRENCE OF CROHN'S DISEASE: A PROSPECTIVE LONGITUDINAL STUDY

Author

L. Biancone, G.S. Sica, Sara Onali, Francesco Pallone, Carmelina Petruzziello, M. Cossignani, Emma Calabrese, and Francesca Zorzi

Subjects
medicine.medical_specialty, Longitudinal study, Crohn's disease, business.industry, media_common.quotation_subject, medicine.disease, Small intestine, law.invention, medicine.anatomical_structure, Capsule endoscopy, law, medicine, Contrast (vision), Radiology, Ultrasonography, business, media_common
Published
2007
Full Text
View/download PDF

182. P070 WIRLESS CAPSULE ENDOSCOPY IN CROHN'S DISEASE: CLINICAL RELEVANCE OF UPPER GI LESIONS AND FEASIBILITY 2 YEARS AFTER ILEO-COLONIC RESECTION

Author

Sara Onali, M. Cossignani, L. Biancone, Francesco Pallone, Carmelina Petruzziello, G. Del Vecchio Blanco, Emma Calabrese, and G.S. Sica

Subjects
medicine.medical_specialty, Crohn's disease, Capsule endoscopy, law, business.industry, Internal medicine, Colonic resection, Medicine, Clinical significance, business, medicine.disease, Gastroenterology, law.invention
Published
2007
Full Text
View/download PDF

183. Newly diagnosed neoplasia in Crohn's Disease patients treated with infliximab: A 1 year longer follow up from a multicenter matched-pair study

Author

L. Biancone, Carmelina Petruzziello, G. Meucci, Fabiana Castiglione, D. Checchin, A. Cocco, Francesco Pallone, Emma Calabrese, F. Mocciaro, M. Cottone, E. Angelucci, R. Sostegni, Anna Kohn, A. Orlando, Gabriele Riegler, Enrico Colombo, and Claudio Papi

Subjects
Crohn's disease, medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, Medicine, Newly diagnosed, business, medicine.disease, Infliximab, medicine.drug, Matched pair
Published
2006
Full Text
View/download PDF

185. Transnasal gastroscopy without sedation versus transoral gastroscopy under sedation: A randomised prospective study on accuracy, acceptability, feasibility and safety

Author

L. Biancone, Omero Alessandro Paoluzi, C. Tosti, I. Stroppa, E. Grasso, Francesco Pallone, S. Mazzocchi, and Cinzia Razzini

Subjects
Under sedation, Hepatology, business.industry, Anesthesia, Sedation, Gastroenterology, Medicine, medicine.symptom, business, Prospective cohort study
Published
2006
Full Text
View/download PDF

186. 50 P Anti-COX2 treatment in patients with inflammatory bowel

Author

Francesco Pallone, Ivan Monteleone, L. Biancone, C. Tosti, G. Del Vecchio Blanco, P. Vavassori, G. Monteleone, F. De Nigris, and Daniele Fina

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, Medicine, In patient, business
Published
2002
Full Text
View/download PDF

188. 57 OP Tropomyosin isoform 5 expression in gastric intestinal metaplasia: A novel subclinical marker of intestinal-type gastric cancer?

Author

Alfredo Colantoni, L. Biancone, C. Angeloni, L. Anemona, S. Fratoni, A. Mauriello, Kiron M. Das, Giuseppe Palmieri, Francesco Pallone, and Luigi Giusto Spagnoli

Subjects
Gene isoform, Intestinal type, Pathology, medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, Cancer, medicine.disease, Tropomyosin, Gastric Intestinal Metaplasia, Medicine, business, Subclinical infection
Published
2002
Full Text
View/download PDF

190. PO-2

Author

L. Biancone, M.C. Di Paolo, Francesco Pallone, Paolo Paoluzi, Adriana Marcheggiano, Francesco Scopinaro, and P. Ierardi

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Medicine, Early detection, Radiology, Nuclear Medicine and imaging, General Medicine, Radiology, Disease, business, Scintigraphy
Published
1997
Full Text
View/download PDF

191. SP-5. Radiolabelled interleukin-2 scintigraphy for imaging CD25+ mononuclear cells in chronic inflammation

Author

Elena Bonanno, Luigi Giusto Spagnoli, Alberto Signore, L. Biancone, Marco Chianelli, Paolo Pozzilli, G. Nardi, S. Morrone, and Francesco Pallone

Subjects
Interleukin 2, Pathology, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Inflammation, General Medicine, Scintigraphy, Peripheral blood mononuclear cell, Immunology, Medicine, Radiology, Nuclear Medicine and imaging, IL-2 receptor, medicine.symptom, business, medicine.drug
Published
1997
Full Text
View/download PDF

192. Usefulness of salivary Helicobacter pylori antibodies

Author

Maria Imeneo, L. Biancone, Francesco Pallone, Francesco Luzza, and M Maletta

Subjects
Hepatology, biology, business.industry, Immunology, Gastroenterology, biology.protein, Medicine, Helicobacter pylori, Antibody, business, biology.organism_classification
Published
1995
Full Text
View/download PDF

193. Usefulness of scintigraphy using 99mTc-EMPAO labelled granulocytes (PMN) as early indicator of postoperative asymptomatic recurrence in Crohn's disease (CD)

Author

M.C. Di Paolo, Francesco Scopinaro, Francesco Pallone, Adriana Marcheggiano, L. Di Macio, Paolo Paoluzi, and L. Biancone

Subjects
Crohn's disease, Pathology, medicine.medical_specialty, Hepatology, medicine.diagnostic_test, business.industry, Gastroenterology, medicine, medicine.symptom, Scintigraphy, business, medicine.disease, Asymptomatic
Published
1995
Full Text
View/download PDF

194. Peripheral and intestinal lymphocyte activation after in vitro exposure to cow's milk antigens in normal subjects and in patients with Crohn's disease

Author

Roberto Paganelli, Stefano Fais, Giampiero D'Offizi, Francesco Pallone, O Squarcia, and L. Biancone

Subjects
Adult, Male, Interleukin 2, medicine.medical_specialty, Lymphocyte, Immunology, Transferrin receptor, Lactoglobulins, Lymphocyte Activation, Peripheral blood mononuclear cell, Pathology and Forensic Medicine, Lesion, Crohn Disease, Antigen, Reference Values, Internal medicine, medicine, Animals, Humans, Immunology and Allergy, Lymphocytes, Antigens, Lamina propria, Crohn's disease, Blood Cells, business.industry, Middle Aged, medicine.disease, Intestines, Milk, medicine.anatomical_structure, Endocrinology, Lactalbumin, Female, medicine.symptom, business, medicine.drug
Abstract

We studied in Crohn's disease and controls the in vitro activation of either peripheral (PBMNC) or intestinal (LPMNC) mononuclear cells in response to the cow's milk antigen beta-lactoglobulin (Blg). The activation of mononuclear cells was investigated by analyzing the kinetics of the transferrin receptor (T9 antigen) and interleukin 2 receptor (Tac antigen) expression. In both controls and Crohn's disease patients Blg (1 microgram/ml) induced a significant (P less than 0.01) increase of T9 and Tac expression by both PBMNC and LPMNC cultured for 3 days. After Blg exposure the counts of T9- and Tac-bearing cells were significantly (P less than 0.05) higher in PBMNC cultures from healthy controls than in those from patients with Crohn's disease. In both groups peripheral T-enriched cell suspensions did not express T9 and Tac when stimulated with Blg but were restored to express either antigen by the addition of 10% autologous adherent cells. In LPMNC cultures from patients with Crohn's disease the Tac expression after 3 days of Blg stimulation was significantly (P less than 0.05) higher than in the autologous PBMNC. Data from this study indicate that in both controls and patients with Crohn's disease lymphocytes sensitized to Blg occur in the circulation as well as in the gut lamina propria. Our data also suggest that in Crohn's disease an increased proportion of lymphocytes sensitized to Blg are recruited from the circulation into the site of the intestinal lesion.

Published
1987
Full Text
View/download PDF

195. HLA-DR antigens on colonic epithelial cells in inflammatory bowel disease: I. Relation to the state of activation of lamina propria lymphocytes and to the epithelial expression of other surface markers

Author

S, Fais, F, Pallone, O, Squarcia, L, Biancone, F, Ricci, P, Paoluzi, and M, Boirivant

Subjects
HLA-D Antigens, Crohn Disease, Colon, Antigens, Surface, Receptors, Transferrin, Fluorescent Antibody Technique, Humans, Colitis, Ulcerative, HLA-DR Antigens, Intestinal Mucosa, Lymphocyte Activation, Epithelium, Research Article
Abstract

The colonic epithelial expression of HLA-DR molecules and of other markers of cell membrane perturbation was investigated by immunofluorescence in biopsy specimens from patients with ulcerative colitis and Crohn's disease. It was found that in virtually all specimens from either groups showing active inflammation there was a diffuse epithelial expression of HLA-DR molecules. There was no relation between the grading of active inflammation and the epithelial expression of HLA-DR antigens. The epithelium of virtually all specimens from the macro and microscopically uninvolved areas of patients with active colitis and from patients with histologically quiescent colitis showed no detectable expression of HLA-DR molecules. The counts of isolated lamina propria lymphocytes expressing the transferrin receptor and the interleukin 2 receptor were higher in specimens with HLA-DR+ epithelium than in those with a HLA-DR- epithelium. Twenty-nine of the 35 (83%) HLA-DR positive specimens proved to express the 4F2 antigen on their epithelium and 19 (54%) were positive for the transferrin receptor. All sections positive for either the 4F2 antigen or the transferrin receptor were also HLA-DR positive while all HLA-DR negative sections were also negative for either of the two other markers. Data in this study suggest that in active IBD the epithelial participation in active inflammation is associated with a sequence of cell membrane rearrangements, and that the expression of HLA-DR molecules is a part of this sequence.

Published
1987

196. T cell differentiation antigens expressed by peripheral blood lymphocytes in Crohn's disease

Author

F, Pallone, O, Squarcia, S, Fais, M, Boirivant, L, Biancone, and G, Tonietti

Subjects
Adult, Antigens, Differentiation, T-Lymphocyte, Male, Leukocyte Count, Crohn Disease, Antigens, Surface, Antibodies, Monoclonal, Humans, Female, Lymphocytes
Abstract

The aim of the present study was to investigate whether an imbalance of peripheral blood immunoregulatory T cells is a feature of Crohn's disease. The cluster of differentiation antigens 3,4 and 8 were investigated and the relative prevalence of PBL expressing each antigen was defined using a panel of three monoclonal antibodies (OKT3, OTK4 and OKT8). A significant decrease in the OKT3 and OKT4 positive cells was found in CD patients as compared with healthy controls. No significant difference was observed between patients and controls in the proportion of T8 positive cells and in the T4/T8 ratio. While confirming a significant decrease of circulating total resting T cells in patient with CD, the results of this study indicate that the disease is not primarily related to an imbalance of the proportion of the T cells subsets.

Published
1985

199. Imaging techniques for assessment of inflammatory bowel disease: Joint ECCO and ESGAR evidence-based consensus guidelines

Author

M.A. Bali, Dominik Weishaupt, Jaap Stoker, Jeroen A. W. Tielbeek, Shaji Sebastian, Daniel C. Baumgart, Andrea Laghi, Gerhard Rogler, Yoram Bouhnik, Doug Pendse, Giovanni Morana, Fernando Magro, Livia Biancone, D. Tolan, Davide Bellini, Jordi Rimola, J. Martín-Comín, Stuart A. Taylor, Francesca Maccioni, Steve Halligan, B. Marincek, Torsten Kucharzik, Walter Reinisch, Roberto Grassi, B. Wiarda, Fabiana Castiglione, Alberto Signore, A. Ba-Ssalamah, Silvio Danese, G. Van Assche, Giovanni Maconi, Laurent Peyrin-Biroulet, Julián Panés, Robert Ehehalt, Celso Matos, Sandro Ardizzone, Panes, J, Bouhnik, Y, Reinisch, W, Stoker, J, Taylor, Sa, Baumgart, Dc, Danese, S, Halligan, S, Marincek, B, Matos, C, Peyrin Biroulet, L, Rimola, J, Rogler, G, van Assche, G, Ardizzone, S, Ba Ssalamah, A, Bali, Ma, Bellini, D, Biancone, L, Castiglione, F, Ehehalt, R, Grassi, Roberto, Kucharzik, T, Maccioni, F, Maconi, G, Magro, F, Martín Comín, J, Morana, G, Pendsé, D, Sebastian, S, Signore, A, Tolan, D, Tielbeek, Ja, Weishaupt, D, Wiarda, B, Laghi, A., AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA -Cancer Center Amsterdam, Radiology and Nuclear Medicine, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBERehd), Liver Unit, Clínica Universitaria, CIBER-EHD, Service de Gastroentérologie [Hôpital Beaujon], Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Department Internal Medicine III [Medizinische Universität Wien], Medizinische Universität Wien = Medical University of Vienna, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), University College London Hospitals (UCLH), Charité Campus Virchow-Klinikum (CVK), Department of Gastroenterology [Humanitas Research Hospital], Humanitas Research Hospital, University Hospitals Case Medical Center (CLEVELAND - UHCMC), University Hospitals Case Medical Center, Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Vall d'Hebron University Hospital [Barcelona], Division of Gastroenterology and Hepatology [Zurich], Universität Zürich [Zürich] = University of Zurich (UZH)-University hospital of Zurich [Zurich], Mt. Sinai Hospital [Toronto, Canada], University Hospital L. Sacco (ICPS), Department of Radiology [Medizinische Universität Wien], Department of Radiological Oncologic and Pathologic Sciences, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Department of Internal Medicine, Università degli Studi di Roma Tor Vergata [Roma], Università degli studi di Napoli Federico II, Heidelberg University Hospital [Heidelberg], Seconda Università degli studi di Napoli, Städtisches Klinikum Lüneburg, Hospital de São João [Porto], Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Hospital of Treviso, Castle Hill Hospital, Hull & East Yorkshire Hospitals NHS Trust, Nuclear Medicine Unit [Sapienza Roma], Leeds General Infirmary (LGI), Leeds Teaching Hospitals NHS Trust, Stadtspital Triemli Zürich, Medical Center Alkmaar, Peyrin-Biroulet, L, Ba-Ssalamah, A, Grassi, R, Martin-Comin, J, Pendse, D, Laghi, A, J., Pane, Y., Bouhnik, W., Reinisch, J., Stoker, S. A., Taylor, D. C., Baumgart, S., Danese, S., Halligan, B., Marincek, C., Mato, L., Peyrin Biroulet, J., Rimola, G., Rogler, G. v., Assche, S., Ardizzone, A., Ba Ssalamah, M. A., Bali, D., Bellini, L., Biancone, Castiglione, Fabiana, R., Ehehalt, R., Grassi, T., Kucharzik, F., Maccioni, G., Maconi, F., Magro, J., Martín Comín, G., Morana, D., Pendsé, S., Sebastian, A., Signore, D., Tolan, J. A., Tielbeek, D., Weishaupt, B., Wiarda, and A., Laghi

Subjects
Diagnostic Imaging, medicine.medical_specialty, Consensus, Evidence-based practice, [SDV]Life Sciences [q-bio], Consensus, Diagnostic Imaging, MEDLINE, diagnosis/pathology, 030218 nuclear medicine & medical imaging, Primary sclerosing cholangitis, 03 medical and health sciences, Magnetic resonance imaging, 0302 clinical medicine, medicine, Medical imaging, Humans, Intensive care medicine, Computed tomography, Ultrasonography, Settore MED/12 - Gastroenterologia, Crohn's disease, Magnetic resonance cholangiopancreatography, Evidence-Based Medicine, medicine.diagnostic_test, business.industry, Gastroenterology, Ulcerative colitis, Europe, Inflammatory Bowel Diseases, General Medicine, Evidence-based medicine, medicine.disease, 3. Good health, standards, Europe, Evidence-Based Medicine, Humans, Inflammatory Bowel Disease, 030211 gastroenterology & hepatology, Radiology, business
Abstract

International audience; The management of patients with IBD requires evaluation with objective tools, both at the time of diagnosis and throughout the course of the disease, to determine the location, extension, activity and severity of inflammatory lesions, as well as, the potential existence of complications. Whereas endoscopy is a well-established and uniformly performed diagnostic examination, the implementation of radiologic techniques for assessment of IBD is still heterogeneous; variations in technical aspects and the degrees of experience and preferences exist across countries in Europe. ECCO and ESGAR scientific societies jointly elaborated a consensus to establish standards for imaging in IBD using magnetic resonance imaging, computed tomography, ultrasonography, and including also other radiologic procedures such as conventional radiology or nuclear medicine examinations for different clinical situations that include general principles, upper GI tract, colon and rectum, perineum, liver and biliary tract, emergency situation, and the postoperative setting. The statements and general recommendations of this consensus are based on the highest level of evidence available, but significant gaps remain in certain areas such as the comparison of diagnostic accuracy between different techniques, the value for therapeutic monitoring, and the prognostic implications of particular findings.

Published
2013
Full Text
View/download PDF

200. Sindrome epato-renale

Author

Gaetano La Manna, G. Garibotto - R. Pontremoli - L. Biancone, and Gaetano La Manna

Subjects
Sindrome epato-renale, Insufficienza renale acuta, Creatinina, Ipertesione portale
Abstract

Non applicabile

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results