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The massive cluster MACSJ1149.5+2223(z = 0.544) displays five very large lensed images of a well-resolved spiral galaxy at z = 1.491. It is within one of these images that the first example of a multiply lensed supernova (SN) has been detected recently as part of the Grism Lens-Amplified Survey from Space. The depth of this data also reveals many H II regions within the lensed spiral galaxy which we identify between the five counter-images. Here, we expand the capability of our free-form method to incorporate these H II regions locally, with other reliable lensed galaxies added for a global solution. This improved accuracy allows us to estimate when the Refsdal SN will appear within the other lensed images of the spiral galaxy to an accuracy of ~7 per cent. We predict this SN will reappear in one of the counter-images (RA = 11:49:36.025, Dec. = +22:23:48.11, J2000) and on 2015 November 1 (with an estimated error of ±25 d) it will be at the same phase as it was when it was originally discovered, offering a unique opportunity to study the early phases of this SN and to examine the consistency of the mass model and the cosmological model that have an impact on the time delay prediction.

We derive a free-form mass distribution for the massive cluster AS1063 (z = 0.348) using the completed optical imaging from the Hubble Frontier Fields programmme. Based on a subset of 11 multiply lensed systems with spectroscopic redshift, we produce a lens model that is accurate enough to secure new multiply lensed systems, totalling over a 100 arclets, and to estimate their redshifts geometrically. Consistency is found between this precise model and that obtained using only the subset of lensed sources with spectroscopically measured redshifts. Although a relatively large elongation of the mass distribution is apparent relative to the X-ray map, no significant offset is found between the centroid of our mass distribution and that of the X-ray emission map, suggesting a relatively relaxed state for this cluster. For the well-resolved lensed images, we provide detailed model comparisons to illustrate the precision of our model and hence the reliability of our de-lensed sources. A clear linear structure is associated with one such source extending 23 kpc in length, that could be an example of jet-induced star formation, at redshift z ≈ 3.1.

We examine a well-resolved lensed image that is bent by an edge-on lenticular galaxy, in the Hubble Frontier Fields (HFF) data of MACSJ0416.1−20403. The fortuitous combination of a long arc (zs ≈ 1 ± 0.2) intersecting an edge-on galaxy from the cluster (z = 0.4) provides an opportunity to constrain its dark matter (DM) halo and its orientation. We model the stellar lensing contribution and we add to this a standard parametrized dark halo component. Irrespective of the detailed choice of parameters, we obtain a combined total mass of ≈3 × 1011 M⊙. Depending on the dark halo parameters, the stellar contribution to this is limited to the range 5–15 × 1010 M⊙, or 20–50 per cent of the total mass, in good agreement with the independent (photmetric) stellar mass of 5 × 1010 M⊙ (Chabrier IMF), or 8 × 1010 M⊙ (Salpeter IMF). The major axis of the DM halo is constrained to be nearly orthogonal to the plane of the galaxy, and with an ellipticity e ≈ 0.15 corresponding to an axis ratio a/c = 0.54. We show that these conclusions are very weakly dependent on the model of the cluster, or the additional influence of neighbouring galaxies or the properties of the lensed source. Alternative theories of gravity that do not require DM are challenged by this finding since generically these must be tied to the baryonic component which is highly disfavoured by our results. Other such fortuitously useful lenses can be examined this way as they become uncovered with more HFF data to help provide a more statistical distribution of galaxy halo properties.

We examine the latest data on the clusterMACSJ0717.5+3745 from the Hubble Frontier Fields campaign. The critically lensed area is the largest known of any lens and very irregular making it a challenge for parametric modelling. Using our free-form method we obtain an accurate solution, identify here many new sets of multiple images, doubling the number of constraints and improving the reconstruction of the dark matter distribution. Our reconstructed mass map shows several distinct central substructures with shallow density profiles, clarifying earlier work and defining well the relation between the dark matter distribution and the luminous and X-ray peaks within the critically lensed region. Using our free-form method, we are able to meaningfully subtract the mass contribution from cluster members to the deflection field to trace the smoothly distributed cluster dark matter distribution. We find four distinct concentrations, three of which are coincident with the luminous matter. The fourth peak has a significant offset from both the closest luminous and X-ray peaks. These findings, together with dynamical data from the motions of galaxies and gas will be important for uncovering the potentially important implications of this extremely massive and intriguing system.

We examine the latest data on the cluster MACSJ0717.5+3745 from the Hubble Frontier Fields campaign. The critically lensed area is the largest known of any lens and very irregular making it a challenge for parametric modelling. Using our Free-Form method we obtain an accurate solution, identify here many new sets of multiple images, doubling the number of constraints and improving the reconstruction of the dark matter distribution. Our reconstructed mass map shows several distinct central substructures with shallow density profiles, clarifying earlier work and defining well the relation between the dark matter distribution and the luminous and X-ray peaks within the critically lensed region. Using our free-form method, we are able to meaningfully subtract the mass contribution from cluster members to the deflection field to trace the smoothly distributed cluster dark matter distribution. We find 4 distinct concentrations, 3 of which are coincident with the luminous matter. The fourth peak has a significant offset from both the closest luminous and X-ray peaks. These findings, together with dynamical data from the motions of galaxies and gas will be important for uncovering the potentially important implications of this extremely massive and intriguing system., Comment: 16 pages, 10 figures, 2 tables. Matches the verson submitted to mnras. New table (A2) included with additional system candidates

We examine a well resolved 8 arcsec lensed image that is symmetrically bent in the middle by an edge-on lenticular galaxy, in the Hubble Frontier Field (HFF) data of MACSJ0416.1-20403. The lengthy image is generated primarily by the large tangential shear of the cluster with a local secondary deflection by the member galaxy out to a limiting radius of about 18 kpc. The lensing lenticular galaxy is also well resolved and evidently lies nearly edge-on in projection. This fortuitous combination of a long arc intersecting an edge on galaxy provides us with an opportunity to place relatively strong constraints on the lensing effect of this galaxy. We can model the stellar lensing contribution using the observed pixels belonging to the galaxy, in 2D, and we add to this a standard parameterised dark halo component. Irrespective of the detailed choice of parameters we obtain a combined total mass of about 3E11 Msun. Depending on the dark halo parameters, the stellar contribution to this is limited to the range 5-15E10 Msun or 20-50 percent of the total mass, in good agreement with the independent stellar mass computed from the photometry of 5E10 Msun for a Chabrier IMF, or 8E10Msun for a Salpeter IMF. The major axis of the DM halo is constrained to be nearly orthogonal to the plane of the galaxy, within a range of about 15 degrees, and with an ellipticity e=015 corresponding to an axis ratio a/c=0.54. We show that these conclusions are very weakly dependent on the model of the cluster, or the additional influence of neighbouring galaxies or the properties of the lensed source. Alternative theories of gravity where the radial dependence is modified to avoid the need for DM are challenged by this finding since generically these must be tied to the baryonic component which here is a stellar disk oriented nearly orthogonally to the lensed image deflection., Comment: 7 pages, 7 figures

The deflection angles of lensed sources increase with their distance behind a given lens. We utilize this geometric effect to corroborate the $z_{phot}\simeq9.8$ photometric redshift estimate of a faint near-IR dropout, triply-imaged by the massive galaxy cluster Abell 2744 in deep Hubble Frontier Fields images. The multiple images of this source follow the same symmetry as other nearby sets of multiple images which bracket the critical curves and have well defined redshifts (up to $z_{spec}\simeq3.6$), but with larger deflection angles, indicating that this source must lie at a higher redshift. Similarly, our different parametric and non-parametric lens models all require this object be at $z\gtrsim4$, with at least 95\% confidence, thoroughly excluding the possibility of lower-redshift interlopers. To study the properties of this source we correct the two brighter images for their magnifications, leading to a SFR of $\sim0.3 M_{\odot}$/yr, a stellar mass of $\sim4\times10^{7} M_{\odot}$, and an age of $\lesssim220$ Myr (95\% confidence). The intrinsic apparent magnitude is 29.9 AB (F160W), and the rest-frame UV ($\sim1500 \AA$) absolute magnitude is $M_{UV,AB}=-17.6$. This corresponds to $\sim0.1 L^{*}_{z=8}$ ($\sim0.2 L^{*}_{z=10}$, adopting $dM^{*}/dz\sim0.45$), making this candidate one of the least luminous galaxies discovered at $z\sim10$., Comment: 7 pages, 4 figures, 1 table; V2: very minor changes, ApJ Letters Accepted

Hubble Frontier Fields (HFF) imaging of the most powerful lensing clusters provides access to the most magnified distant galaxies. The challenge is to construct lens models capable of describing these complex massive, merging clusters so that individual lensed systems can be reliably identified and their intrinsic properties accurately derived. We apply the free-form lensing method (WSLAP+) to A2744, providing a model independent map of the cluster mass, magnification, and geometric distance estimates to multiply-lensed sources. We solve simultaneously for a smooth cluster component on a pixel grid, together with local deflections by the cluster member galaxies. Combining model prediction with photometric redshift measurements, we correct and complete several systems recently claimed, and identify 4 new systems - totalling 65 images of 21 systems spanning a redshift range of 1.4

The formation of synapses, the specialized points of chemical communication between neurons, is a highly regulated developmental process fundamental to establishing normal brain circuitry. Perturbations of synapse formation and function causally contribute to human developmental and degenerative neuropsychiatric disorders, such as Alzheimer's disease, intellectual disability, and autism spectrum disorders. Many genes controlling synaptogenesis have been identified, but lack of facile experimental systems has made systematic discovery of regulators of synaptogenesis challenging. Thus, we created a high-throughput platform to study excitatory and inhibitory synapse development in primary neuronal cultures and used a lentiviral RNA interference library to identify novel regulators of synapse formation. This methodology is broadly applicable for high-throughput screening of genes and drugs that may rescue or improve synaptic dysfunction associated with cognitive function and neurological disorders., National Institutes of Health (U.S.) (MH095096), National Institutes of Health (U.S.) (R01 GM089652)