715 results on '"Leadlay, Peter F."'
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152. Identification of a Phosphopantetheinyl Transferase for Erythromycin Biosynthesis in Saccharopolyspora erythraea.
153. A New Modular Polyketide Synthase in the Erythromycin Producer Saccharopolyspora erythraea
154. Biosynthetic Gene Cluster of the Glycopeptide Antibiotic Teicoplanin
155. Identification of a Phosphopantetheinyl Transferase for Erythromycin Biosynthesis in Saccharopolyspora erythraea
156. Catalytically Active Tetramodular 6-Deoxyerythonolide B Synthase Fusion Proteins
157. A Novel Erythromycin, 6‐Desmethyl Erythromycin D, Made by Substituting an Acyltransferase Domain of the Erythromycin Polyketide Synthase.
158. Biosynthetic engineering of polyketide synthases
159. Intermediates Released from a Polyether‐Producing Polyketide Synthase Provide Insight into the Mechanism of Oxidative Cyclization
160. The Structure of Docking Domains in Modular Polyketide Synthases
161. Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272
162. Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulceransElectronic supplementary information (ESI) available: Experimental procedures and ESI-CID-MS/MS spectra of mycolactone and the five co-metabolites; MS3 spectrum of m/z 661 from the MS/MS of m/z 749; scheme showing the losses of mass 88 (C4H8O2) during the MS/MS of m/z 749 and the MS3 of m/z 661. See http://www.rsc.org/suppdata/cc/b3/b308163j/
163. Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase
164. Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthaseElectronic supplementary information (ESI) available: Further details of the construction of pCJR308, the fermentation of BIOT-0966 and the isolation of pentaketide lactone, 3, and figures showing the13C NMR and 1H COSY spectra of 3. See http://www.rsc.org/suppdata/ob/b3/b310740j/
165. Skipping in a Hybrid Polyketide Synthase
166. Engineered biosynthesis of novel spinosyns bearing altered deoxyhexose substituentsElectronic supplementary information (ESI) available: 1H and 13C NMR data for compounds 5–8. See http://www.rsc.org/suppdata/cc/b2/b200536k/
167. Chain initiation on the soraphen-producing modular polyketide synthase from Sorangium cellulosum
168. Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase
169. Molecular basis of Celmer’s rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates
170. Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase
171. Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units
172. Efficient purification and kinetic characterization of a bimodular derivative of the erythromycin polyketide synthase
173. Structural elucidation studies of polyketide tetrasubstituted δ-lactones by gas chromatography/tandem mass spectrometry and electrospray mass spectrometry
174. Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues
175. Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry II
176. Molecular basis of celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase
177. ChemInform Abstract: Enantiospecific Synthesis of Tetrasubstituted δ‐Lactones.
178. Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry
179. The Enzymology of Polyketide Antibiotic Biosynthesis
180. Enantiospecific synthesis of tetrasubstituted δ-lactones
181. Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase
182. Stabilization of Radical Intermediates by an Active-Site Tyrosine Residue in Methylmalonyl-CoA Mutase,
183. Phosphorylation of the Periplasmic Binding Protein in Two Transport Systems for Arginine Incorporation in Escherichia coli K-12 Is Unrelated to the Function of the Transport System
184. Construction of new vectors for high-level expression in actinomycetes
185. Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension
186. Origin of Starter Units for Erythromycin Biosynthesis
187. The Thioesterase of the Erythromycin-Producing Polyketide Synthase: Influence of Acyl Chain Structure on the Mode of Release of Substrate Analogues from the Acyl Enzyme Intermediates
188. Die Thioesterase der Polyketid-Synthase von Erythromycin: Einfluß der Acylkettenstruktur auf den Abkopplungsmechanismus der Substratanaloga von der Acyl-Enzym-Zwischenstufe
189. Mutational Biosynthesis of Novel Rapamycins by a Strain of Streptomyces hygroscopicus NRRL 5491 Disrupted in rapL , Encoding a Putative Lysine Cyclodeaminase
190. Tritium Isotope Effects and Site‐Directed Mutagenesis as Probes of the Reaction Catalysed by Methylmalonyl‐CoA Mutase
191. Engineering Broader Specificity into an Antibiotic-Producing Polyketide Synthase
192. Sugaring the pill by design
193. Novel Erythromycins from a Recombinant Saccharopolyspora erythraea Strain NRRL 2338 pIG1. I. Fermentation, Isolation and Biological Activity.
194. The Molecular Basis of Celmer's Rules: The Stereochemistry of the Condensation Step in Chain Extension on the Erythromycin Polyketide Synthase
195. Combinatorial approaches to polyketide biosynthesis
196. The Pipecolate-Incorporating Enzyme for the Biosynthesis of the Immunosuppressant Rapamycin - Nucleotide Sequence Analysis, Disruption and Heterologous Expression of Rap P from Streptomyces Hygroscopicus
197. The Nature of the Starter Unit for the Rapamycin Polyketide Synthase
198. Die Startereinheit der Rapamycin-Polyketid-Synthase
199. A hybrid modular polyketide synthase obtained by domain swapping
200. Homology modeling of human methylmalonyl-CoA mutase: A structural basis for point mutations causing methylmalonic aciduria
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