Search

Your search keyword '"Lennon, Vanda A."' showing total 1,204 results
Start Over Author "Lennon, Vanda A."
1,204 results on '"Lennon, Vanda A."'

151. Brief report: inhibition of renal phosphate transport by a tumor product in a patient with oncogenic osteomalacia

Author

Cai, Qiang, Hodgson, Stephen F., Kao, Pai C., Lennon, Vanda A., Klee, George G., Zinsmiester, Alan R., and Kumar, Rajiv

Subjects
Osteomalacia -- Causes of, Hemangioma -- Complications, Tumors -- Complications
Abstract

The presence of a tumor may affect the chemical processes of the body. A 47-year-old woman reported weakness and aching in her arms and legs. A hemangioma, or tumor consisting of blood vessels, was removed from her thigh. Her condition, diagnosed as oncogenic osteomalacia, improved. Oncogenic osteomalacia is a softening of the bones resulting from a tumor or cancer. A medium of sclerosing hemangioma cells extracted from the tumor was found to inhibit phosphate transport in renal epithelial cells without increasing cellular concentrations of cyclic adenosine monophosphate (cAMP). The medium had a low molecular weight and was sensitive to heat.

Published
1994

154. The association of pauciarticular juvenile arthritis and myasthenia gravis

Author

Glass, John B., Sher, Phyllis K., Lennon, Vanda A., and Regelmann, Warren E.

Subjects
Myasthenia gravis -- Diagnosis, Rheumatoid arthritis in children -- Case studies, Family and marriage, Health
Abstract

The presence of more than one autoimmune disease (one in which the body manufactures antibodies against its own proteins) in a patient at the same time is fairly common, exemplified by the frequent coexistence of myasthenia gravis (MG; a relapsing neuromuscular disorder) and adult rheumatoid arthritis. Two case histories are presented of children with juvenile arthritis (JA) and MG, a rare combination since JA is usually present alone. The patients had pauciarticular JA (disease affecting only a few joints). One was diagnosed with JA at the age of six and one half, and developed weakness, slurred speech, and difficulty swallowing at the age of nine. The arthritis was inactive when MG was diagnosed but flared up again several months after the thymus was removed (a treatment for MG in many cases). The second case involved a girl who was 13 when diagnosed with JA. At age 16, she developed muscle weakness and was ultimately diagnosed with MG. Both patients underwent treatment for their conditions. The coexistence of JA and MG in two children seen in the same clinic was surprising, since they are so rarely seen together. Two other cases have appeared in the literature where JA preceded MG by a few years. The family histories of the two patients presented here showed the presence of other possibly autoimmune diseases. A common defect of the immune system is postulated. Children with JA who complain of weakness should be tested for antibodies against the acetylcholine receptor (a sign of MG) and evaluated for abnormalities of muscle function. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

160. Phosphodiesterase 10A IgG

Author

Zekeridou, Anastasia, primary, Kryzer, Thomas, additional, Guo, Yong, additional, Hassan, Anhar, additional, Lennon, Vanda, additional, Lucchinetti, Claudia F., additional, Pittock, Sean, additional, and McKeon, Andrew, additional

Published
2019
Full Text
View/download PDF

163. GABAA receptor autoimmunity

Author

O'Connor, Kevin, primary, Waters, Patrick, additional, Komorowski, Lars, additional, Zekeridou, Anastasia, additional, Guo, Chu-Yueh, additional, Mgbachi, Victor C., additional, Probst, Christian, additional, Mindorf, Swantje, additional, Teegen, Bianca, additional, Gelfand, Jeffrey M., additional, Geschwind, Michael D., additional, Lennon, Vanda, additional, Pittock, Sean J., additional, and McKeon, Andrew, additional

Published
2019
Full Text
View/download PDF

166. Myelin Oligodendrocyte Glycoprotein Antibody–Positive Optic Neuritis: Clinical Characteristics, Radiologic Clues, and Outcome

Author

Chen, John J., primary, Flanagan, Eoin P., additional, Jitprapaikulsan, Jiraporn, additional, López-Chiriboga, Alfonso (Sebastian) S., additional, Fryer, James P., additional, Leavitt, Jacqueline A., additional, Weinshenker, Brian G., additional, McKeon, Andrew, additional, Tillema, Jan-Mendelt, additional, Lennon, Vanda A., additional, Tobin, W. Oliver, additional, Keegan, B. Mark, additional, Lucchinetti, Claudia F., additional, Kantarci, Orhun H., additional, McClelland, Collin M., additional, Lee, Michael S., additional, Bennett, Jeffrey L., additional, Pelak, Victoria S., additional, Chen, Yanjun, additional, VanStavern, Gregory, additional, Adesina, Ore-Ofe O., additional, Eggenberger, Eric R., additional, Acierno, Marie D., additional, Wingerchuk, Dean M., additional, Brazis, Paul W., additional, Sagen, Jessica, additional, and Pittock, Sean J., additional

Published
2018
Full Text
View/download PDF

167. Association of MOG-IgG Serostatus With Relapse After Acute Disseminated Encephalomyelitis and Proposed Diagnostic Criteria for MOG-IgG–Associated Disorders

Author

López-Chiriboga, A. Sebastian, primary, Majed, Masoud, additional, Fryer, James, additional, Dubey, Divyanshu, additional, McKeon, Andrew, additional, Flanagan, Eoin P., additional, Jitprapaikulsan, Jiraporn, additional, Kothapalli, Naga, additional, Tillema, Jan-Mendelt, additional, Chen, John, additional, Weinshenker, Brian, additional, Wingerchuk, Dean, additional, Sagen, Jessica, additional, Gadoth, Avi, additional, Lennon, Vanda A., additional, Keegan, B. Mark, additional, Lucchinetti, Claudia, additional, and Pittock, Sean J., additional

Published
2018
Full Text
View/download PDF

168. Predictors of neural-specific autoantibodies and immunotherapy response in patients with cognitive dysfunction

Author

Dubey, Divyanshu, primary, Kothapalli, Naga, additional, McKeon, Andrew, additional, Flanagan, Eoin P., additional, Lennon, Vanda A., additional, Klein, Christopher J., additional, Britton, Jeffrey W., additional, So, Elson, additional, Boeve, Bradley F., additional, Tillema, Jan-Mendelt, additional, Sadjadi, Reza, additional, and Pittock, Sean J., additional

Published
2018
Full Text
View/download PDF

169. Aquaporin-4 and Myelin Oligodendrocyte Glycoprotein Autoantibody Status Predict Outcome of Recurrent Optic Neuritis

Author

Jitprapaikulsan, Jiraporn, primary, Chen, John J., additional, Flanagan, Eoin P., additional, Tobin, W. Oliver, additional, Fryer, Jim P., additional, Weinshenker, Brian G., additional, McKeon, Andrew, additional, Lennon, Vanda A., additional, Leavitt, Jacqueline A., additional, Tillema, Jan-Mendelt, additional, Lucchinetti, Claudia, additional, Keegan, B. Mark, additional, Kantarci, Orhun, additional, Khanna, Cheryl, additional, Jenkins, Sarah M., additional, Spears, Grant M., additional, Sagan, Jessica, additional, and Pittock, Sean J., additional

Published
2018
Full Text
View/download PDF

175. Astrocyte-microglia interaction drives evolving neuromyelitis optica lesion.

Author

Tingjun Chen, Lennon, Vanda A., Liu, Yong U., Bosco, Dale B., Yujiao Li, Min-Hee Yi, Jia Zhu, Shihui Wei, Long-Jun Wu, Chen, Tingjun, Li, Yujiao, Yi, Min-Hee, Zhu, Jia, Wei, Shihui, and Wu, Long-Jun

Subjects
*NEUROMYELITIS optica, *SUBARACHNOID space, *COMPLEMENT activation, *SPINAL cord, *ASTROCYTES, *MICROGLIA, *CELL metabolism, *ANIMAL experimentation, *CELL communication, *CELLS, *CELLULAR signal transduction, *COMPARATIVE studies, *COMPLEMENT (Immunology), *RESEARCH methodology, *MEDICAL cooperation, *MEMBRANE proteins, *MICE, *RESEARCH, *EVALUATION research
Abstract

Neuromyelitis optica (NMO) is a severe inflammatory autoimmune CNS disorder triggered by binding of an IgG autoantibody to the aquaporin 4 (AQP4) water channel on astrocytes. Activation of cytolytic complement has been implicated as the major effector of tissue destruction that secondarily involves myelin. We investigated early precytolytic events in the evolving pathophysiology of NMO in mice by continuously infusing IgG (NMO patient serum-derived or AQP4-specific mouse monoclonal), without exogenous complement, into the spinal subarachnoid space. Motor impairment and sublytic NMO-compatible immunopathology were IgG dose dependent, AQP4 dependent, and, unexpectedly, microglia dependent. In vivo spinal cord imaging revealed a striking physical interaction between microglia and astrocytes that required signaling from astrocytes by the C3a fragment of their upregulated complement C3 protein. Astrocytes remained viable but lost AQP4. Previously unappreciated crosstalk between astrocytes and microglia involving early-activated CNS-intrinsic complement components and microglial C3a receptor signaling appears to be a critical driver of the precytolytic phase in the evolving NMO lesion, including initial motor impairment. Our results indicate that microglia merit consideration as a potential target for NMO therapeutic intervention. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

176. LGI1 and CASPR2 neurological autoimmunity in children

Author

López-Chiriboga, A. Sebastian, primary, Klein, Christopher, additional, Zekeridou, Anastasia, additional, McKeon, Andrew, additional, Dubey, Divyanshu, additional, Flanagan, Eoin P., additional, Lennon, Vanda A., additional, Tillema, Jan-Mendelt, additional, Wirrell, Elaine C., additional, Patterson, Marc C., additional, Gadoth, Avi, additional, Aaen, J. Gregory, additional, Brenton, J. Nicholas, additional, Bui, Jonathan D., additional, Moen, Amanda, additional, Otten, Catherine, additional, Piquet, Amanda, additional, and Pittock, Sean J., additional

Published
2018
Full Text
View/download PDF

180. The Mayo Clinic Glial Autoimmunity Study: AQP4/MOG-IgG serostatus and outcomes in 228 patients presenting with recurrent optic neuritis (S13.007)

Author

Jitprapaikulsan, Jiraporn, primary, Chen, John, additional, Fryer, James, additional, Weinshenker, Brian, additional, McKeon, Andrew, additional, Lennon, Vanda, additional, Leavitt, Jacqueline, additional, Flanagan, Eoin P., additional, Tobin, W. Oliver, additional, Lopez Chiriboga, A. Sebastian, additional, Keegan, B. Mark, additional, Lucchinetti, Claudia, additional, Kantarci, Orhun, additional, Sagen, Jessica, additional, and Pittock, Sean, additional

Published
2018
Full Text
View/download PDF

183. The Mayo Clinic Glial Autoimmunity Study: Glial autoantibody (AQP4/MOG/GFAP) serostatus in recurrent longitudinally extensive transverse myelitis (P6.409)

Author

Jitprapaikulsan, Jiraporn, primary, Lopez Chiriboga, A. Sebastian, additional, Flanagan, Eoin P., additional, Fryer, James, additional, McKeon, Andrew, additional, Yujuan, Jiao, additional, Weinshenker, Brian, additional, Majed, Masoud, additional, Tobin, W. Oliver, additional, Keegan, B. Mark, additional, Lucchinetti, Claudia, additional, Lennon, Vanda, additional, Sagen, Jessica, additional, and Pittock, Sean, additional

Published
2018
Full Text
View/download PDF

185. Neuronal Intermediate Filament Autoimmunity (S52.005)

Author

Basal, Eati, primary, Kryzer, Thomas, additional, Dubey, Divyanshu, additional, Guo, Yong, additional, Hinson, Shannon, additional, Majed, Masoud, additional, Benarroch, Eduardo, additional, Lucchinetti, Claudia, additional, Pittock, Sean, additional, Lennon, Vanda, additional, and McKeon, Andrew, additional

Published
2018
Full Text
View/download PDF

186. The Incidence and Prevalence of Autoimmune Encephalitis and a comparison to Infectious Encephalitis: A Population-Based Study (P5.401)

Author

Dubey, Divyanshu, primary, Pittock, Sean, additional, Kelly, Cecilia, additional, McKeon, Andrew, additional, Lopez-Chiriboga, A. Sebastian, additional, Lennon, Vanda, additional, Gadoth, Avi, additional, Smith, Carin, additional, Bryant, Sandra, additional, Klein, Christopher, additional, Aksamit, Allen, additional, Toledano, Michel, additional, Boeve, Bradley, additional, Tillema, Jan Mendelt, additional, and Flanagan, Eoin, additional

Published
2018
Full Text
View/download PDF

187. The Mayo Clinic Glial Autoimmunity study: Persistence of MOG-IgG seropositivity predicts relapse after ADEM in both children and adults (S13.004)

Author

Lopez Chiriboga, A. Sebastian, primary, Majed, Masoud, additional, Fryer, James, additional, McKeon, Andrew, additional, Flanagan, Eoin P., additional, Tillema, Jan-Mendelt, additional, Chen, John, additional, Dubey, Divyanshu, additional, Kothapalli, Naga, additional, Sagen, Jessica, additional, Gadoth, Avi, additional, Weinshenker, Brian, additional, Wingerchuk, Dean, additional, Keegan, B. Mark, additional, Lucchinetti, Claudia, additional, Lennon, Vanda, additional, and Pittock, Sean, additional

Published
2018
Full Text
View/download PDF

188. Elevated LGI1-IgG CSF index predicts worse neurological outcome

Author

Gadoth, Avi, primary, Zekeridou, Anastasia, additional, Klein, Christopher J., additional, Thoreson, Colton J., additional, Majed, Masoud, additional, Dubey, Divyanshu, additional, Flanagan, Eoin P., additional, McKeon, Andrew, additional, Jenkins, Sarah M., additional, Lennon, Vanda A., additional, and Pittock, Sean J., additional

Published
2018
Full Text
View/download PDF

196. IgLON5 antibody

Author

Honorat, Josephe A., primary, Komorowski, Lars, additional, Josephs, Keith A., additional, Fechner, Kai, additional, St Louis, Erik K., additional, Hinson, Shannon R., additional, Lederer, Sabine, additional, Kumar, Neeraj, additional, Gadoth, Avi, additional, Lennon, Vanda A., additional, Pittock, Sean J., additional, and McKeon, Andrew, additional

Published
2017
Full Text
View/download PDF

197. Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica

Author

Shimizu, Fumitaka, primary, Schaller, Kristin L., additional, Owens, Gregory P., additional, Cotleur, Anne C., additional, Kellner, Debra, additional, Takeshita, Yukio, additional, Obermeier, Birgit, additional, Kryzer, Thomas J., additional, Sano, Yasuteru, additional, Kanda, Takashi, additional, Lennon, Vanda A., additional, Ransohoff, Richard M., additional, and Bennett, Jeffrey L., additional

Published
2017
Full Text
View/download PDF

198. Expanded phenotypes and outcomes among 256 LGI1/CASPR2-IgG-positive patients

Author

Gadoth, Avi, primary, Pittock, Sean J., additional, Dubey, Divyanshu, additional, McKeon, Andrew, additional, Britton, Jeff W., additional, Schmeling, John E., additional, Smith, Aurelia, additional, Kotsenas, Amy L., additional, Watson, Robert E., additional, Lachance, Daniel H., additional, Flanagan, Eoin P., additional, Lennon, Vanda A., additional, and Klein, Christopher J., additional

Published
2017
Full Text
View/download PDF

199. Predictive models in the diagnosis and treatment of autoimmune epilepsy

Author

Dubey, Divyanshu, primary, Singh, Jaysingh, additional, Britton, Jeffrey W., additional, Pittock, Sean J., additional, Flanagan, Eoin P., additional, Lennon, Vanda A., additional, Tillema, Jan-Mendelt, additional, Wirrell, Elaine, additional, Shin, Cheolsu, additional, So, Elson, additional, Cascino, Gregory D., additional, Wingerchuk, Dean M., additional, Hoerth, Matthew T., additional, Shih, Jerry J., additional, Nickels, Katherine C., additional, and McKeon, Andrew, additional

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results