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Ventilation is essential to the health and comfort of occupants in enclosed spaces. However, it is difficult to accurately measure the ventilation rates in large, long, and narrow spaces such as aircraft cabins and train compartments. This study has proposed a modified tracer-gas-concentration decay method that combines the multi-zone technique with the genetic algorithm to determine ventilation rate in such spaces. To validate the proposed method, the investigation utilized both the modified decay method and the traditional decay method to numerically measure the ventilation rate in an MD-82 aircraft cabin by computational fluid dynamics technique. The results showed that the modified tracer-gas-concentration decay method can significantly improve the accuracy and reliability of the ventilation rate measurements in such a large, long, and narrow space. The modified tracer-gas-concentration decay method was also used to experimentally measure the ventilation rate in an actual MD-82 aircraft cabin. Although no exact ventilation rate could be measured, but compared with the traditional tracer-gas-concentration decay method, the ventilation rate determined by the modified method was much closer to that obtained by the constant tracer-gas-concentration method, which is considered to be the most accurate measurement. [ABSTRACT FROM PUBLISHER]

• University education and future income are significantly connected with creativity and critical thinking. • Students who developed and used creativity and critical thinking skills in the process of education had bigger success in future work, which influenced their income. • The quality of university training is reflected in the personal income of graduates and can be objectively assessed by this criterion. • The size of a graduate's income may also depend on his/her age. The problem of students' income is characterized by relevance taking into account the fact that its level depends on the level of the development of professional competencies that are necessary in modern world according to the quick improvement of technological process. The role of modern skills of creativity and critical thinking in the process of obtaining education and future income is determined. The study included 3 500 graduates of 28 selected universities, united into 280 homogeneous groups, which were examined through big data analysis. According to a survey conducted in the first stage before studying under the developed program, only 35% of students rated their level of creativity as high, with 40% having an average level of creativity and 25% of respondents having a low level of creativity, indicating a lack of tasks for development of this professional skill in the curriculum. The received answers show that the most developed critical thinking skills are problem-solving (82%) and analysis (73%). The results of the survey showed that teachers still use traditional teaching methods, as evidenced by the indicators of tasks to improve skills of creativity and critical thinking, as dominated by «reading and learning new things» (37%), «comprehension and analysis of information» (33%). The second stage of the experiment presupposed studying under the developed program consisting of two thematic modules. The purpose of this program was to develop the level of students' creativity and critical thinking skills and determine the influence of them on the students' income. The results of the re-survey show the increasing of the level of students' income as well as in 6 universities, at least one group of respondents had earnings of more than 20 thousand yuan/month, while only one university had 5 groups where incomes of all participants exceeded 20 thousand yuan/month. Compared with the results of the first survey after the studying of the developed program, the indicators of the development of critical thinking skills according to the results of the re-survey increased, the percentage of which is represented by the following indicators: problem-solving (92%), analysis (85%), interpretation (75%), inference (80%), explanation (74%), open-mindedness (63%), self-regulation (66%). The results of the repeated survey on student income proved the effectiveness of training according to the developed curriculum, as evidenced by the obtained indicators of student income levels: the high level (21%), average (25%), below average (25%), above average (10%)), low (5%) and those who do not work (4%). The results of the research can be applied for a more in-depth study of temporal correlations in income fluctuations among graduates of an educational institution. Moreover, the gained outcomes can contribute to the identification of patterns to create a model for determining the quality of education in universities and colleges, in particular, the development of curricula and programs to take into account the work on improving the practical skills of creativity and critical thinking. [ABSTRACT FROM AUTHOR]

The adsorption and desorption of Am(III) on a calcareous soil (sierozem) and its parent material (loess) were studied by batch technique. The molarities of the Am(III) aqueous solutions were less than 5 . 10-9 mol/l. High adsorbability was found of Am(III) on the calcareous soil and its parent material. In order to decrease the adsorption and, hence, to investigate the adsorption characteristics properly, stable Eu3+ as hold back carrier and analogue was added to the aqueous solution. The relative contributions of CaCO3, organic matter (OM) to the Am(III) adsorption on calcareous soil and its parent material were investigated. The adsorption and desorption isotherms of Am(III) on untreated soil and loess and the three kinds of treated soils and three kinds of treated loesses to remove CaCO3, OM and both CaCO3 and OM were determined, respectively. It was found that all isotherms were linear, the average distribution coefficients (K-d) for the untreated soil and for the untreated loess were almost equal, while there was an obvious difference between the values of the average distribution coefficients (K-d) for the treated soil and the treated loess to remove CaCO3 or OM. The adsorption-desorption hysteresis on the untreated and treated soils and loesses actually occurred and there was an obvious difference between the hysteresis coefficients on both the corresponding treated soil and loess. It can be concluded that the adsorbability of Am(III) on calcareous soil is similar to that on its parent material, and that the contributions of CaCO3 and OM to the Am(III) adsorption by the untreated soil are different from those by the untreated parent material. [ABSTRACT FROM AUTHOR]

The sorption and desorption isotherms of untreated calcareous soil and three treated soils to remove CaCO3, organic matter (OM) and both CaCO3 and OM were determined and analyzed with the Freundlich equation at pH 7.8, moderate concentrations of NpO2+ (~10-5 mol/l), in the presence of 0.01 mol/l CaCl2 and under ambient aerobic conditions. The relative contribution of CaCO3 and OM to the neptunium(V) sorption on calcareous soil and the sorption/desorption hysteresis is discussed. The effects of adding fulvic acid (FA) and carbonate in to the solution on the sorption of neptunium(V) on the soils were also studied. The sorption and desorption characteristics of NpO2+, Zn2+, Sr2+ and Cs+ on the soils are compared. [ABSTRACT FROM AUTHOR]

Metal oxide semiconductors (MOSs) are widely used gas-sensing materials because of their large response values and fast response speed. However, high operating temperature hinders the development of MOS-based gas sensors. To detect SF 6 decomposition components (including H 2 S, SO 2 , SOF 2 , and SO 2 F 2), here, we have synthesized cerium oxide nanoparticles (CeO 2 NPs) via a facile hydrothermal routine, followed by functionalization with Au, Ag, and Pd noble metals to improve sensor performance. Our developed CeO 2 -based sensor exhibited high response to target gases at a low working temperature. After doping various metals into the CeO 2 NPs, we acquired distinct patterns of dynamic responses for SF 6 decomposition components. Au functionalization could maximize the enhancements of sensor responses to H 2 S (976%), SO 2 (153%), and SOF 2 (151%) at 100 °C, and a Pd-modified CeO 2 -based sensor exhibited optimal response to SO 2 F 2 at a relatively high temperature of 250 °C. In addition, high response values, short response–recovery times, good repeatability, and low detection limits were also obtained from CeO 2 -based sensors. Our results verified that doping different noble metals into CeO 2 NPs should be a promising strategy to design high-performance gas sensors for SF 6 decomposition component detection. Unlabelled Image • Pristine and Au, Ag, Pd functionalized cerium oxide nanoparticles are synthesized via a hydrothermal method. • The responses of Au-CeO 2 to H 2 S, SO 2 and SOF 2 are improved to 976%, 153% and 151% at 100 °C. • Pd-CeO 2 nanoparticles express the largest surface area (76.031 m2/g), and show best response to SO 2 F 2. • The prepared CeO 2 -based sensors present short response time (~1 min) and low detection limits (under 0.5 ppm). [ABSTRACT FROM AUTHOR]

• Adsorption properties of SF6 decomposition components on ceria surface were compared based on DFT calculations. • Adsorption of H 2 S, SO 2 and SOF 2 cause conspicuous charge redistribution on CeO 2 (110) surface. • CeO 2 (110) shows higher sensitivity to H 2 S, SO 2 and SOF 2 in comparison with SF 6. The detection of sulfur hexafluoride (SF 6) decomposition components is significant for monitoring the conditions of SF 6 -gas-insulated equipment. In present study, the adsorption of SF 6 and its decomposition components (H 2 S, SO 2 , SOF 2 , and SO 2 F 2) on ceria (110) was investigated by performing calculations based on density functional theory (DFT). Adsorption energy, adsorption configuration, charge transfer, density of states, potential energy and work function for molecular adsorption were adopted to evaluate the performance of ceria (110) on sensing SF 6 decomposition components. Among all the gas molecules, H 2 S, SO 2 and SOF 2 were chemically adsorbed on ceria surface with the adsorption energy following the order: SOF 2 > SO 2 > H 2 S, while SO 2 F 2 and SF 6 were physically adsorbed on the substrate. Besides, the amount of charge transfer and work function modification of H 2 S, SO 2 and SOF 2 molecule's adsorption were larger than those of SO 2 F 2 and SF 6. These calculation results demonstrated ceria (110) showed prominent sensitivity to H 2 S, SO 2 and SOF 2 while less activity to SF 6 , which means sensor based on ceria is promising for detecting H 2 S, SO 2 and SOF 2 in SF 6 gas background, and thus has the potential to online monitor the working condition of SF 6 -gas-insulated equipment. [ABSTRACT FROM AUTHOR]

In this work, thermomechanical treatment (single-pass rolling at 800 °C and solution treatment) was applied to nuclear-grade hot-rolled austenitic stainless steel to eliminate the mixed grain induced by the uneven hot-rolled microstructure. By employing high-temperature laser scanning confocal microscopy, microstructure evolution during solution treatment was observed in situ, and the effect of single-pass rolling reduction on it was investigated. In uneven hot-rolled microstructure, the millimeter-grade elongated grains (MEGs) possessed an extremely large size and a high Schmid factor for slip compared to the fine grains, which led to greater plastic deformation and increased dislocation density and deformation energy storage during single-pass rolling. During subsequent solution treatment, there were fewer nucleation sites for the new grain, and the grain boundary (GB) was the main nucleation site in MEGs at a lower rolling reduction. In contrast, at a higher reduction, increased uniformly distributed rolling deformation and more nucleation sites were developed in MEGs. As the reduction increased, the number of in-grain nucleation sites gradually exceeded that of GB nucleation sites, and in-grain nucleation preferentially occurred. This was beneficial for promoting the refinement of new recrystallized grains and a reduction in the size difference of new grains during recrystallization. The single-pass rolling reduction of 15–20% can effectively increase the nucleation sites and improve the uniformity of rolling deformation distribution in the MEGs, promote in-grain nucleation, and finally refine the abnormally coarse elongated grain, and eliminate the mixed-grain structure after solution treatment. [ABSTRACT FROM AUTHOR]

This study aimed to develop and validate a nomogram model of central venous access device–related thrombosis (CRT) for hospitalized children. A total of 503 consecutive cases from a hospital in Changsha City, Hunan Province were stochastically classified into the training set and internal validation set at a ratio of 7:3, and 85 consecutive cases in two hospitals in Urumqi City, Xinjiang Uygur Autonomous Region were collected as an external validation set. Univariate analysis and multivariate analysis on CRT-related risk factors of hospitalized children were conducted, a logistic regression model was employed to establish the nomogram, and the discrimination, calibration, and decision curve analysis was performed to assess the proposed nomogram model. The nomogram model involved seven independent risk factors, including blind catheterization, abnormal liver function, central line–associated bloodstream infection, infection, number of catheter lines, leukemia, and bed rest > 72 h. The discrimination results showed that the area under the receiver operating characteristic curve of the training set, internal validation set, and external validation set was 0.74, 0.71, and 0.76 respectively, and the accuracy rates of the proposed nomogram model were 79%, 72%, and 71% in the training set, internal validation set, and external validation set. The calibration results also showed that the calibration curve had great fitness for each dataset. More importantly, the decision curve suggested that the proposed nomogram model had a prominent clinical significance. Conclusion: The nomogram model can be used as a risk assessment tool to reduce the missed diagnosis rate and the incidence of CRT in hospitalized children. What is Known: • Central venous access device–related thrombosis is generally asymptomatic for hospitalized children, causing the missed diagnosis of central venous access device–related thrombosis easily. • No risk prediction nomogram model for central venous access device–related thrombosis in hospitalized children has been established. What is New: • A visual and personalized nomogram model was built by seven accessible variables (blind catheterization, abnormal liver function, central line–associated bloodstream infection, infection, number of catheter lines, leukemia, and bed rest > 72 h). • The model can effectively predict the risk of central venous access device–related thrombosis for hospitalized children. [ABSTRACT FROM AUTHOR]

In article number 2200771, Qihang Pang and co-workers show here that under relatively high-heat-input welding, yttrium mainly exists in the form of Y SB 2 sb O SB 3 sb oxide in steel. Y SB 2 sb O SB 3 sb near the parent austenite grain boundary can effectively block the overall migration of grain boundaries. Y SB 2 sb O SB 3 sb in the parent austenite grain can also promote the formation of new grain and sub-grain boundaries to separate and refine the proto-austenite grains. [Extracted from the article]

Simple Summary: Lactoferrin (LF) is considered to be an important active protein in goat milk, and it plays an important role in immunity. In this study, we tried to find factors affecting the expression of lactoferrin. Furthermore, we further explored the anti-inflammatory effect of LF and related molecular mechanisms in order to further understand how lactoferrin affects the immune system and provide a reference for further study and application of lactoferrin in the future. Lactoferrin (LF) is believed to be an important active protein in goat milk, which plays an anti-inflammatory role. Although LF has been reported to be associated with body health, its exact underlying mechanism remains unclear. Here, we aimed to elucidate the mechanism of this anti-inflammatory effect of LF in vitro. We first identified that miR-214-5p inhibited the expression of LF mRNA and protein in cells through the 3′UTR of LF mRNA. We next identified the alterations in miRNA following LF overexpression in goat mammary epithelial cells (GEMCs). Overexpression of LF significantly increased (p < 0.05) miR-224-5p expression. We further revealed that transcriptional activation of ADAM17, TNF-α, IL-1β, and IL-6 was efficiently decreased (p < 0.05) in GMECs treated by miR-224-5p mimic. Conversely, knockdown of miR-224-5p increased (p < 0.05) ADAM17, TNF-α, IL-1β, and IL-6 expression. Additionally, TNF-α, IL-1β, and IL-6 expression levels were dramatically decreased in GMECs after administration of siADAM17. Herein, we indicate that the miR-214-5p/LF/miR-224-5p/ADAM17 axis is involved in the immune regulation of GEMCs. [ABSTRACT FROM AUTHOR]

Central venous access device-related thrombosis (CRT) is a common complication in hospitalized children. The pediatric nurses' knowledge, attitude, and practice are of great significance for CRT prevention in hospitalized children. The purpose of this study was to elaborate on the level and influencing factors of pediatric nurses' knowledge, attitude, and practice on the prevention related to CRT in hospitalized children. This national cross-sectional study was carried out in China from January 16, 2021, to April 23, 2021. A multi-stage sampling method was adopted, and 1060 pediatric nurses from 21 hospitals participated in this study. The current situation and influencing factors of pediatric nurses' knowledge, attitude, and practice were investigated by descriptive statistics, approximate t test or independent-sample t test, nonparametric Kruskal–Wallis H test, one-way analysis of variance, and multiple linear regression analysis. The relationship among pediatric nurses' knowledge, attitude, and practice was explored by the Pearson correlation analysis. Among all pediatric nurses involved in this study, 25% had insufficient knowledge, 18% had negative attitudes, and 24% had poor behaviors. The main influencing factors on the knowledge, attitude, and practice included the highest education level of pediatric nurses (β = 0.10, P =.001), whether received training related to CRT prevention (β = 0.09–0.14, P <.01), whether CRT-related knowledge was enough for dealing with clinical work (β = 0.18–0.21, P <.001), and the importance of hospitals/departments on children CRT prevention (β = 0.16–0.24, P <.001). There was a positive correlation between knowledge, attitude, and practice (r = 0.24–0.77, P <.01). Conclusion: Pediatric nurses' CRT-prevention knowledge and practice are unsatisfactory, while their preventive attitude toward CRT prevention is optimistic. This study assists the formulation of comprehensive intervention strategies for pediatric nurses in preventing CRT in hospitalized children by hospital-related organizations and nursing managers, so as to improve the participation of pediatric nurses in CRT prevention and reduce the occurrence of CRT for hospitalized children. What is Known: • As a common complication in hospitalized children, CRT can induce many potentially serious complications. • A professional nursing team is an important prerequisite for reducing CRT incidence. What is New: • The levels of pediatric nurses' knowledge and practice are not satisfactory, while pediatric nurses' preventive attitude toward CRT prevention is optimistic. • Hospital-related organizations and nursing managers should highlight the importance of CRT prevention and encourage pediatric nurses to improve their expertise and strengthen the training related to CRT prevention. [ABSTRACT FROM AUTHOR]

Background: Venous thromboembolism (VTE) including Deep Venous Thrombosis (DVT) and Pulmonary Embolism (PE), is a serious cause of patient morbidity and mortality in hospitals. Neurosurgical hospitalized patients have higher rates of immobility and bed rest, thus increasing their risk of developing VTE. This highlights the need for their thromboprophylaxis regimens. Patients' awareness of VTE is essential for promoting strategies such as early ambulation and encouraging self-assessment and self-reporting of VTE signs and symptoms. This study evaluated neurosurgical hospitalized patients' awareness of VTE and explored the influencing factors to provide a theoretical basis for nursing intervention. Methods: We selected one tertiary level hospital in Hunan Province and randomly sampled eligible patients from each five neurosurgical units. We conducted a cross-sectional survey of the hospitalized patients of neurosurgery using the self-designed and validated VTE knowledge questionnaire, and the influencing factors were analyzed using SPSS 26.0. Results: A total of 386 neurosurgical hospitalized patients completed the survey. The score of VTE knowledge in neurosurgical hospitalized patients was 13.22 (SD = 11.52). 36.0% and 21.2% of participants reported they had heard of DVT and PE, respectively. 38.9% of participants were unable to correctly identify any symptoms of VTE. The most frequently identified risk factor was 'immobility or bed rest for more than three days' (50.0% of participants), and 38.1% of patients agreed that PE could cause death. 29.5% of participants were unable to identify any prophylactic measures of VTE. The results of Negative Binomial Regression showed that the influencing factors of VTE knowledge in neurosurgical hospitalized patients were education level (P < 0.004) and sources of information related to VTE, including nurses (95% CI = 2.201–4.374, P < 0.001), and family member/friend (95% CI = 2.038–4.331, P < 0.001), Internet/TV (95% CI = 1.382–2.834, P < 0.001). Other sources included patient /pamphlet/poster /professional books (95% CI = 1.492–3.350, P < 0.001). Conclusions: This study demonstrates the lack of awareness of VTE among neurosurgical hospitalized patients. More attention must be paid to carrying out training on VTE knowledge according to different characteristics of neurosurgical hospitalized patients, so as to ensure safe and high-quality patient care. [ABSTRACT FROM AUTHOR]

Low‐carbon development is associated with eco‐industrial parks (EIPs), but whether a causal relationship exists is unknown. A growing body of evidence from environmental engineering studies suggests that EIPs reduce carbon emissions, but few economic studies have assessed the causality, channels, and heterogeneity of this relationship. This study uses the staggered difference‐in‐difference method to construct a quasi‐natural experiment to assess the impact of national‐level EIPs on low‐carbon development. The empirical results reveal that EIPs help achieve low‐carbon development in China. Specifically, EIPs reduce the carbon intensity of the pilot cities by 7.2%. The channel analysis reveals that EIPs advance technological innovation, stimulate the Porter effect, and upgrade the industrial structure. Regional heterogeneity analysis further reveals that EIPs are more conducive to low‐carbon development in pilot cities in southern China, cities along the coast, and cities on the east of the Hu line. Further analysis shows that EIPs depress the peak of the environmental Kuznets curve and help achieve the turning point early. Moreover, this study offers fresh cases and patterns for the construction of EIPs in China. This study contributes to an in‐depth understanding of the role of EIPs in the low‐carbon transition in the largest developing country and provides inspiration for further policy optimization. [ABSTRACT FROM AUTHOR]

Abstract: The electropolymerization of thionine with the guidance of DNA molecular template was described in this paper. The prepared polythionine (PTH) dispersed uniformly on the electrode surface and presented a novel flexual nanostrip morphology with the average diameter of 90nm and length of 500nm. However, PTH fabricated without DNA-guided electropolymerization presented a clustered granular morphology. The electrochemical redox behavior of PTH via DNA-guided electropolymerization was considerably enhanced compared to that of PTH without DNA molecular template. The significant improvement of the redox property might be attributed to the in situ PTH chains growth along DNA strands. In neutral environment, the PTH/DNA on the carbon paste electrode showed a pair of well-defined redox peaks and excellent electrocatalytic activity toward the reduction of H2O2. Under optimal conditions, H2O2 was amperometrically determined by using the as-prepared PTH/DNA nanostrips in the concentration range of 0.99–8.26mM. [Copyright &y& Elsevier]

Abstract: The detection of DNA damage is one of the most important topics in the DNA research fields. In the present work, oppositely charged natural dsDNA and poly(diallyldimethyl ammonium chloride) (PDDA) were assembled into (PDDA/dsDNA)3 layer-by-layer films on electrode surface, and Ru(bpy)3 2+ and Co(phen)3 3+ in solution were used as electroactive probes to detect oxidative damage of natural dsDNA in the films after incubation of the films in V2O5 nanobelts/HCl/H2O2 solution. The mechanism of DNA oxidative damage caused by the V2O5 nanobelts/HCl/H2O2 system was similar to that of Fenton-type reaction. The reaction of V2O5 nanobelts with HCl would produce V(IV), and the produced V(IV) would further react with H2O2, generating hydroxyl radicals (OHhe Fenton-type reaction, which could severely damage DNA in the films. The present work provided an in vitro model system to mimic the pathway of DNA damage in real bioprocess through a simple electrochemical approach combined with layer-by-layer assembly. This approach also showed promising applications in rapid and sensitive screening of new nanomaterials and chemicals in vitro for their potential genotoxicity. [Copyright &y& Elsevier]

Pathological hypertrophy generally progresses to heart failure. Exploring effective and promising therapeutic targets might lead to progress in preventing its detrimental outcomes. Our current knowledge about lipopolysaccharide-induced tumor necrosis factor-α factor (LITAF) is mainly limited to regulate inflammation. However, the role of LITAF in other settings that are not that relevant to inflammation, such as cardiac remodeling and heart failure, remains largely unknown. In the present study, we found that the expression of LITAF decreased in hypertrophic hearts and cardiomyocytes. Meanwhile, LITAF protected cultured neonatal rat cardiomyocytes against phenylephrine-induced hypertrophy. Moreover, using LITAF knockout mice, we demonstrated that LITAF deficiency exacerbated cardiac hypertrophy and fibrosis compared with wild-type mice. Mechanistically, LITAF directly binds to the N-terminal of ASK1, thus disrupting the dimerization of ASK1 and blocking ASK1 activation, ultimately inhibiting ASK1-JNK/p38 signaling over-activation and protecting against cardiac hypertrophy. Furthermore, AAV9-mediated LITAF overexpression attenuated cardiac hypertrophy in vivo. Conclusions: Our findings uncover the novel role of LITAF as a negative regulator of cardiac remodeling. Targeting the interaction between LITAF and ASK1 could be a promising therapeutic strategy for pathological cardiac remodeling. [Display omitted] • LITAF protein was decreased in hypertrophic hearts. • LITAF protects against cardiac hypertrophy both in vitro and in vivo. • LITAF regulates cardiac hypertrophy via inhibiting ASK1-JNK/p38 signaling activation. • LITAF blocks ASK1 activation via disrupting its N-terminal dimerization. [ABSTRACT FROM AUTHOR]

• The porous structure was adjusted by controlling the oxygen content. • Concave ligament/pore structure was prepared by annealing in lower oxygen content. • The oxide consisted of Cu 2 O and CuO, the ratio of which depended on oxygen content. In this work, by controlling the oxygen content during the annealing, the porous golds with different pore structures were prepared after dealloying of Au 25 Cu 75 alloys. Annealing in 2 ppm O 2 , a loose oxide film could be observed on the alloy surface, mainly of Cu 2 O, partly of CuO. As the surface oxide was etched away in concentrated HNO 3 , the precursor alloy formed a unique concave ligament/pore structure. With the increase of the oxygen content, the oxide film became denser, and the proportion of CuO increased significantly. After dealloying, a macroporous gold was obtained, due to the oxidation, diffusion and dissolution of copper atoms. [ABSTRACT FROM AUTHOR]

The long non-coding RNA (lncRNA) LIFR-AS1 has been shown to be involved in the development of several human cancers. This study was designed to determine the expression profile and role of lncRNA-LIFR-AS1 in human thyroid cancer. The results showed significant (p < 0.05) upregulation of LncRNA-LIFR-AS1 in thyroid cancer tissues and cells. However, silencing of LncRNA-LIFR-AS1 inhibited the viability and proliferation of human thyroid cancer cells inducing G2/M cell cycle arrest. The G2/M phase cells increased from 8.56% in negative control (NC) to around 35.03% in si-LIFR-AS1. This was also found to be concomitant with the downregulation of cyclin B1 and CDK1 expressions. The thyroid cancer cells exhibited remarkably lower invasion and migration under transcriptional knockdown of lncRNA-LIFR-AS1 which was also associated with downregulation of MMP-2 and MMP-9 expression. Importantly, transcriptional silencing of lncRNA-LIFR-AS1 inhibited thyroid cancer tumorigenesis, in vivo. Collectively, the results suggest the tumor-promoting role of lncRNA-LIFR-AS1 in thyroid cancer and highlight its potential as therapeutic target. [ABSTRACT FROM AUTHOR]

The evaluation of the service value of coastal wetland ecosystem is of great significance for the scientific development and effective utilization of coastal wetland resources. It has been proved that the addition of attribute cut-offs in the choice experiment (CE) evaluation framework improves the validity of evaluation results. However, whether this improvement is due to the improvement of the questionnaire or the improvement of the utility equation cannot be distinguished with this framework. In this study, the modified selection model with cut-off is used to assess the two key elements of the modified selection model that differ from the traditional model. These are the CE questionnaire that leads to cut-off and the CE utility equation that incorporates cut-off. Each element pair is analyzed separately. Both are utilized to evaluate the impact of the validity of the results, and quantitatively evaluate the service value of the mangrove wetland ecosystem in the Beibu Gulf region, Guangxi, China. The results showed that: In 2021, the total value of mangrove wetland ecosystem services in the Beibu Gulf region was 1.181 billion yuan. In the modified CE model, both the improvement of the questionnaire and the improvement of the utility equation contribute to the improvement of the validity of the evaluation results; their contribution degree is equal. Regarding the choice model, based on the correction, the public's willingness to pay per capita values for strengthening the protection of mangroves are (in order): the improvement of biodiversity, mangrove forest coverage, water quality, and the appreciation of the landscape. Related values are 53.89 yuan, 47.00 yuan, 35.46 yuan, and 17.29 yuan, respectively. The results provide a scientific basis for the formulation of ecological management policies of coastal wetlands by the government. [ABSTRACT FROM AUTHOR]

In order to take insight into the gas sensing performance of single ultrathin WO 3 nanowire, we performed first principles calculation to investigate the gas adsorption properties and used non-equilibrium Green function (NEGF) to investigate the electron transport properties of WO 3 nanowires with gas adsorption. Our investigation indicated that the WO 3 nanowires with/without oxygen vacancies are both sensitive to H 2 S due to the large adsorption energies and distinct charge transfer. Besides, we found that the WO 3 nanowire with O a type oxygen vacancies is highly selective to SO 2. We supposed that the high chemical activity and the small molecular volume of H 2 S and SO 2 are the main reasons of the selectivity. Finally, the negative differential resistance (NDR) effect of single ultrathin WO 3 nanowire and the gate voltage were proposed to benefit the application of WO 3 nanowires gas sensors. We also supposed two ways to take advantage of the NDR effect of single ultrathin WO 3 nanowire in gas sensing applications. It should be noted that this is the first theoretical investigation of WO 3 nanowires gas sensors considering the electron transport properties. Our work highlighted the possibility to use the single ultrathin WO 3 nanowire as superior gas sensors for SO 2 and H 2 S. Image 1 • The single ultrathin WO 3 nanowire without oxygen vacancies was sensitive to H 2 S. • The single ultrathin WO 3 nanowire with oxygen vacancies was sensitive to SO 2. • High chemical activity and small molecular volume are main reasons of selectivity. • Negative differential resistance effect will benefit gas sensing application. [ABSTRACT FROM AUTHOR]

Introduction: Lung cancer remains the primary cause of cancer-related deaths on a global scale. Surgery is the main therapeutic option for non-small cell lung cancer (NSCLC). However, the optimal surgical approach for lymph node assessment in NSCLC resection remains controversial, and it is still uncertain whether lymph node dissection (LND) is more effective in reducing recurrence and metastasis rates in NSCLC compared with lymph node sampling (LNS). Therefore, we will conduct a meta-analysis to evaluate the recurrence and metastasis of LND versus LNS in patients with NSCLC., Methods and Analysis: This systematic review and meta-analysis will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analysis: The PRISMA Statement. According to the predefined inclusion criteria, we will conduct a comprehensive search for randomised controlled trials and non-randomised studies examining the recurrence and metastasis of LND compared with LNS in patients with NSCLC. A literature search from inception in PubMed, EMBASE, the Cochrane Library, CNKI, Wanfang, SINOMED, VIP and Web of Science will be done. There will be no limitations on language, and the search will be undertaken on 30 August 2024, with regular search for new studies. Additionally, relevant literature references will be retrieved and hand-searching of pertinent journals will be conducted. The main outcomes include overall recurrence rate, local recurrence rate and distant metastasis rate. The supplementary outcomes encompass the rates of regional recurrence and lymph node metastasis. Two independent reviewers will perform screening, data extraction and quality assessment. Our reviewers will perform subgroup analysis, sensitivity analysis and publication bias analysis to evaluate the heterogeneity and robustness. Review Manager 5.4 will be applied in analysing and synthesising. The Grading of Recommendations Assessment, Development and Evaluation will be used to assess the quality of evidence for the whole study., Ethics and Dissemination: Ethical approval is dispensable for this study since no private information of the participants will be involved. The findings of the present study will be disseminated through a peer-reviewed journal or conference presentation., Study Registration: The protocol of the systematic review has been registered on Open Science Framework, with a registration doi: https://doi.org/10.17605/OSF.IO/S2FT5., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

In the present study, the welding thermal cycle of magnesium-treated EH36 steel was simulated by a thermal simulation experiment machine. The effects of welding heat input on the microstructure and low temperature toughness of the welded joint were studied, and the mechanism of acicular ferrite nucleation induced by MgAl 2 O 4 inclusion was revealed. The results showed that, when the welding heat input of 150 kJ/cm, 250 kJ/cm and 350 kJ/cm was utilized, the microstructure of heat affected zone in the experimental EH36 steel consisted of grain boundary ferrite, acicular ferrite, granular bainite, and a small amount of pearlite, but the volume fraction and grain size of each independent microstructure were different. With the increase of welding heat input, the content of acicular ferrite and granular bainite decreased, the content of grain boundary ferrite increased, and the average grain size increased, whereas the low temperature toughness of the experimental EH36 steel welded joint reduced from 174 to 67 J. Furthermore, MgAl 2 O 4 inclusions can induce acicular ferrite nucleation, whereas the nucleation mechanism is a combination of low lattice mismatch and low interfacial energy., (© 2024. The Author(s).)

In this paper, the solid solution and precipitation behavior of inclusions on the surface and 1/2 thickness of the tested steel plate under the condition of welding heat input of 400 kJ/cm is investigated by using laser confocal experiments with hot-rolled state DH36 ship plate steel as the research object, and the mechanism of the effect of inclusions on the phase transformation of an acicular ferrite is revealed. The results show that the inclusions of the tested steel are mainly composed of Oxide-MnS, MnS, Oxide, TiN, Spinel, etc. The amount of inclusions on the surface of the tested steel plate is significantly higher than that at the 1/2 thickness position. During the heating stage, the small inclusions on the surface immediately disappeared, and the large inclusions gradually solidified in the matrix; atomic diffusion occurred at the bond between the inclusions and the matrix; while the small inclusions at the 1/2 thickness position gradually disappeared at the beginning of the heating stage, and the inclusions began to precipitate and grow when the temperature was increased to 990 °C. The acicular ferrite preferentially nucleates and grows near the boundary of the inclusions during the post-weld cooling stage, and its growth ends when two acicular ferrites cross., (© 2024. The Author(s).)

This study aimed to evaluate the impact of dietary energy and protein levels on the meat quality and metabolomic profile of Yunshang black goats. For this, 80 Yunshang black goats (male, 6 months old, with a mean live body weight of 35.82 ± 2.79 kg) were used in a completely randomized design with a 2 × 2 factorial dietary arrangement. The dietary treatments were (1) high energy (9.74 MJ/kg) with high protein (12.99%) (HEHP), (2) high energy (9.76 MJ/kg) with low protein (10.01%) (HELP), (3) low energy (8.18 MJ/kg) with high protein (13.04%) (LEHP), and (4) low energy (8.14 MJ/kg) with low protein (10.05%) (LELP). The experiment lasted 64 days, including 14 days for dietary adaptation and a 50-day feeding trial. At the end of the experiment, four animals from each treatment were slaughtered to assess their meat quality and metabolomic profiles. The pH value was greater for the goats fed the LELP diet compared with the other treatments. The LEHP-fed group's meat was brighter ( L *) than that of the other three groups. The HEHP-fed group had considerably more tender meat ( p < 0.05) compared with the LEHP-fed group. Moreover, 72 and 183 differentiated metabolites were detected in the longissimus muscle samples by using gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry, respectively. The hydropathy and volatilities of raw meat were different ( p < 0.05), suggesting changes in the meat flavor because of the dietary treatments. Based on the results, it can be concluded that feeding a high-energy- and high-protein-containing diet improved the tenderness, flavor, and fatty acid contents of mutton.

Today, the number of published scientific articles is increasing day by day, and this has made the process of searching for articles more difficult. The need to provide specific recommender systems (RSs) for suggesting scientific articles is strongly felt in this situation. Because searching for articles based only on matching the titles or content of other articles is not an efficient process. In this research, the combination of two content analysis and citation network is used to design an RS for scientific articles (RECSA). In RECSA, natural language processing and deep learning techniques are used to process the titles and extract the content attributes of the articles. For this purpose, first, the titles of the articles are pre-processed, and by using the Term Frequency Inverse Document Frequency (TF-IDF) criterion, the importance of each word in the title is estimated. Then the dimensions of the obtained attributes are reduced by using a convolutional neural network (CNN). Then, by using the cosine similarity criterion, the content similarity matrix of the articles is calculated based on the attribute vectors. Also, the link prediction approach is used to analyze the connections of scientific articles' citation network. Finally, in the third step of RECSA, the two similarity matrices calculated in the previous steps are combined using an influence coefficient parameter to obtain the final similarity matrix, and the recommendation operation is based on the highest similarity value. The efficiency of RECSA has been evaluated from different aspects and the results have been compared with previous works. According to the results, utilizing the combination of TF-IDF and CNN for analyzing content-based features, leads to at least 0.32 % improvement in terms of precision compared to previous works. Also, by integrating citation and content-based data, the precision of first suggestion in RECSA would be 99.01 % which indicates the minimum improvement of 0.9 % compared to compared methods. The results show that by using RECSA, the recommendation can be done with higher accuracy and efficiency., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Author. Published by Elsevier Ltd.)

Objective: Developing a nursing undergraduate blended teaching quality evaluation tool based on the Context, Input, Process and Product model and evaluating its reliability and validity., Background: Blended teaching is a commonly used teaching method in medical education, but there are limited tools available to effectively measure the quality of blended teaching., Design: A Delphi study and cross-sectional study., Methods: Using the Context, Input, Process and Product model as the theoretical framework, a questionnaire was developed through literature review, expert consultation and pre-survey. From April to July 2023, 448 students from a certain university were selected as the research subjects and the questionnaire was examined for reliability and validity through a survey method., Results: The blended teaching quality evaluation scale with 35 items includes four dimensions Context, Input, Process and Product. The content validity and reliability of the blended teaching quality evaluation scale are both good, with a content validity index of 0.934 for the total scale and a content validity index of 0.750-1.00 for each item. The SEM shows that χ2/df = 6.89, RMSEA = 0.115, CFI = 0.882, NFI=0.865, RFI= 0.855, IFI = 0.882, TLI = 0.873. The Cronbach's α coefficient of the total scale is 0.991 and the Cronbach's α coefficient for each dimension is 0.944-0.984., Conclusion: The scale is based on the characteristics of blended learning and quality evaluation covers all aspects of teaching. It can accurately evaluate the quality of teaching, evaluate the problems in the teaching process based on the teaching quality score and propose reasonable teaching improvement suggestions based on the weak links in the teaching process., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Introduction: Lung cancer remains the largest cause of cancer-related deaths worldwide. Surgical removal of non-small cell lung cancer (NSCLC) has the potential to achieve a cure, although there is ongoing debate regarding the significance of removing mediastinal nodes and the optimal extent of lymph node excision. The purpose of this research is to assess the survival outcomes in patients diagnosed with stage I-IIIA NSCLC who received either complete mediastinal lymphadenectomy (CML) or selective mediastinal lymphadenectomy (SML)., Methods and Analysis: The protocol follows the guidelines recommended in Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols, and this meta-analysis will be conducted in accordance with the standard methodology recommended by the Cochrane Collaboration and reported in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidance. We will conduct a comprehensive search for randomised controlled trials and non-randomised studies examining the effectiveness of CML compared with SML in patients with stage I-IIIA NSCLC. Two authors will perform a comprehensive search of the MEDLINE/PubMed, Embase, the Cochrane Library, CNKI, WanFang, Sinomed, VIP and Web of Science databases. There will be no restrictions on language or publication date, and the search will be conducted on 10 April 2024, with ongoing searches for new research. Reference lists will also be checked and pertinent journals will be hand searched. The primary outcomes include overall survival (OS) and disease-free survival (DFS), while the secondary outcomes consist of 1-year, 3-year and 5-year OS rates and 1-year, 3-year and 5-year DFS rates. Two independent reviewers will screen, extract data, assess quality and evaluate the potential for bias in the selected research, with a third acting as arbitrator. Subgroup analyses and sensitivity analyses are planned. The quality of the evidence will be evaluated using Grading of Recommendations Assessment, Development and Evaluation. Review Manager V.5.4 will be used for the analysis and synthesis process., Ethics and Dissemination: Ethical review and approval are not necessary for this study because it is based on a secondary analysis of the literature. The results will be submitted for reporting in a peer-reviewed publication., Study Registration: Open Science Framework (https://doi.org/10.17605/OSF.IO/PN7UQ)., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Introduction: Lung cancer is the primary cause of cancer-related deaths worldwide, with high rates of morbidity and mortality. The most effective treatment for early stage (I-II) non-small cell lung cancer (NSCLC) is surgical resection. However, the extent of mediastinal lymph nodes removal required and the impact of their removal remains controversial. This systematic review and meta-analysis aimed to evaluate the postoperative complications in patients with stage I-II NSCLC who received mediastinal lymph node dissection (MLND) or mediastinal lymph node sampling (MLNS)., Methods and Analysis: According to the predefined inclusion criteria, we will conduct a comprehensive search for randomized controlled trials (RCTs) and observational studies examining the postoperative complications of MLND compared to MLNS in patients with stage I-II NSCLC. The search will be performed across multiple databases including PubMed, Embase, the Cochrane Library, CNKI, WanFang, Sinomed, VIP, Duxiu, and Web of Science from inception to February 2024. Additionally, relevant literature references will be retrieved and hand searching of pertinent journals will be conducted. Screening, data extraction, and quality assessment will be performed by two independent reviewers. Review Manager 5.4 will be applied in analyzing and synthesizing. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) will be used to assess the quality of evidence for the whole RCTs and used Newcastle-Ottawa scale to assess the methodologic quality of observational studies., Ethics and Dissemination: This study did not include personal information. Ethical approval was not required for this study. This study is based on a secondary analysis of the literature, so ethical review approval is not required. The final report will be published in a peer-reviewed journal., Conclusion: This systematic review will contribute to compare the safety and survival benefits of these two surgical techniques for the treatment of early stage NSCLC, to further guide the selection of surgical approaches., Trial Registration: The protocol of the systematic review has been registered on Open Science Framework, with a registration number of DOI https://doi.org/10.17605/OSF.IO/N2Y5D., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Q690 steel is widely used as building steel due to its excellent performance. In this paper, the microstructure evolution of the heat-affected zone of Q690 steel under simulated high heat input welding conditions was investigated. The results show that under the heat input of 150-300 kJ/cm, the microstructures of the heat-affected zone are lath bainite and granular bainite. The content of lath bainite gradually decreased with the increase in heat input, while the content of granular bainite steadily increased. The proportion of large-angle grain boundaries decreased from 51.1% to 40.3%. Overall, the average size of original austenite increased, and the precipitates changed from Ti (C, N) to Cr carbides. During the cooling process, the nucleation position of bainitic ferrite was from high to low according to the nucleation temperature, and in order of inclusions at grain boundaries, triple junctions, intragranular inclusions, bainitic ferrite/austenite phase boundaries, twin boundaries, grain boundaries, and intragranular inclusions at the bainitic ferrite/austenite phase interface. The growth rate of bainitic ferrite nucleated at the phase interface, grain boundary, and other plane defects was faster, while it was slow at the inclusions. Moreover, it was noted that the Mg-Al-Ti-O composite inclusions promote the nucleation of lath bainitic ferrite, while the Al-Ca-O inclusions do not facilitate the nucleation of bainitic ferrite.

The development of agriculture faces uncertainties due to global climate variability and the scarcity of agricultural resources. Enhancing agricultural development resilience is essential for improving agriculture's adaptability to the external environment and ensuring food security. It is imperative to prevent and control agricultural pollution as it worsens. Thus, enhancing the resilience of agricultural development requires balancing food security and ecological security. The present study constructs an evaluation system for agricultural development resilience in China with three levels: resistance, resilience, and reengineering ability. The agricultural development resilience of China's main grain-producing areas is evaluated using the entropy method, and regional differences are analyzed using kernel density estimation and the Theil index. The obstacle model was used to identify and analyze the obstacles that affect agricultural development's resilience to propose countermeasures. The results showed that (1) agricultural development resilience in China's main grain-producing areas has steadily increased from 0.317 to 0.427. The resilience of agrarian development in Heilongjiang, Shandong, and Henan provinces ranges from 0.473 to 0.575, which is far higher than the mean development level; (2) Regional differences in the main grain-producing areas are narrowing from 0.077 to 0.023; (3) The main grain-producing areas share common obstacle factors, emphasizing the critical role of technological innovation, investment, and machine-cultivated land resources in enhancing agricultural resilience against external risks. Paying attention to the amount of fertilizer usage is crucial to achieving ecological security goals., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Aim: This study aimed to develop and validate a scientific and standardized knowledge, attitude and practice questionnaire of pediatric nurses' preventive care for central venous device-related thrombosis among hospitalized children., Background: Pediatric nurses play a significant role in the prevention of central venous device-related thrombosis for hospialized children. However, the status of pediatric nurses' knowledge, attitude and practice of central venous device-related thrombosis prevention has not been revealed due to the lack of assessment tools., Methods: This questionnaire was framed by the theory of knowledge, attitude and practice. The item pool was compiled through a literature review and a preliminary questionnaire was formed based on expert consultation. A total of 457 pediatric nurses from 10 tertiary class A general hospitals and specialized pediatric hospitals in China were selected for pre-survey. Item analysis, reliability and validity test were conducted to refine and evaluate the items to form a formal questionnaire., Results: A total of 54 items were proposed in three dimensions of knowledge, attitude and practice. In the exploratory factor analysis, five, three and three common factors were extracted for each dimension, accounting for 60.552%, 89.829% and 84.258% of the total variance, respectively. The content validity index of the three dimensions ranged from 0.968 to 1.000 at the scale level and from 0.833 to 1.000 at the item level. The Cronbach's α coefficients for the total questionnaire and each dimension were between 0.926 and 0.973. The retest reliability for the total questionnaire and each dimension was between 0.688 and 0.898., Conclusion: The proposed questionnaire has good reliability and validity and it can be applied to evaluate pediatric nurses' knowledge, attitude and practice in preventing central venous device-related thrombosis for hospitalized children., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

The organic integration of food security and agricultural mechanization has become a challenge to realize a low-carbon economy, which helps promote carbon peaking and carbon neutralization. In this work, a simultaneous equation model has developed to analyze the relationship between food security, agricultural automation, and agricultural carbon emissions in China. The ordinary least square method was used to verify the method. The logarithmic mean Divisia index decomposition was used to decompose further the influencing factors of agricultural carbon emissions. Results show that the organic coupling of a low-carbon economy, food security, and agricultural mechanization positively affects environmental protection. In which, unit fertilizer usage and crop sown area have the greatest impact on carbon emission intensity, followed by agricultural diesel fuel and agricultural plastic film. It is worth noting that the bottom line of the grain sown area cannot be touched. It is a prerequisite for ensuring grain production. Finally, this paper presents suggestions based on China's achievements, where the top-level design is crucial., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

The equipment manufacturing industry is the industrial base of China, which makes it imperative to coordinate the relationship between industrial development and environmental protection. Using panel data of the seven sub-industries in China's equipment manufacturing industry from 2011 to 2015, this paper evaluates the static and dynamic aspects of green economic development efficiency by combining the super-efficiency slack-based measure model of unexpected output and the data envelopment analysis-Malmquist index model. The results show investments in research and development, and environmental regulations have yielded some positive results, but that regulations have also yielded some undesired output in terms of diminished economic benefits. Pure technical efficiency and scale efficiency have both declined, indicating that the scale and industrial structure need to be further optimized. The results of this study present an objective and comprehensive assessment of green economic development of China's equipment manufacturing industry and provide valuable insights for improving green economic development efficiency.

Zinc finger protein 703 (ZNF703), a member of the NET family of transcription factors, has recently emerged as an important player in the development of several types of cancers, though its role in papillary thyroid cancer (PTC) has not been characterized. We investigated the expression of ZNF703, its association with the most common genetic mutation in PTC, BRAF V600E, and its potential use as a therapeutic target. Real-time PCR, immunohistochemical staining, and western blot analysis of ZNF703 expression were performed for 36 cases of PTC and corresponding normal thyroid tissues. ZNF703 mRNA and protein expression was found to be significantly higher in PTC compared to normal thyroid tissues (P < 0.05). Furthermore, expression was associated with the tumor size, lymph node metastasis, and advanced disease stage. Immunohistochemical results showed that there was no correlation between ZNF703 protein levels and BRAF V600E mutation. The human PTC cell line K1, which has a BRAF V600E mutation, was selected for further investigation. Using small interfering RNA (siRNA), ZNF703 was shown to contribute to the proliferation, apoptosis, and invasion of K1 cells. ZNF703-siRNA downregulated E2F1 and MMP9 protein expression and enhanced the expression of p27 protein (P < 0.05), but had no effects on BRAF V600E protein levels. These results suggest that ZNF703 may be of potential use as a new marker for PTC prognosis and therapy that functions independent of BRAF V600E expression.

Immunization with peptides derived from apolipoprotein B-100 (ApoB-100) has been shown to ameliorate atherosclerosis in apolipoprotein E knockout (ApoE -/- ) mice. However, the exact mechanism underlying the therapeutic effects remains elusive. To shed light on this mechanism, we immunized ApoE -/- mice that were fed a Western diet with either malondialdehyde-modified ApoB-100 peptide 210 (P210) emulsified in Freund's adjuvant or anti-malondialdehyde-modified P210 antibody (P210-Ab). Mice immunized with Freund's adjuvant or bovine serum albumin served as controls. Macrophages were incubated in vitro with oxidized low-density lipoprotein (ox-LDL) or ox-LDL plus P210-Ab. Our results show that P210-Ab promoted cholesterol efflux, inhibited lipid accumulation in vitro , and reduced plasma levels of high-sensitivity C-reactive protein (hsCRP), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6). Furthermore, dramatically increased the expression of Fc receptors (FcR) on peripheral blood mononuclear macrophages, suggesting that the mechanism of phagocytosis of ox-LDL by mononuclear macrophages may rely more on FcR than the cluster of differentiation 36 (CD36) scavenger receptor with P210-Ab. Both in vitro and in vivo , P210-Ab triggered the promoter of ATP-binding cassette transporter A1 (ABCA1) to increase peroxisome proliferator-activated receptor alpha (α) activity and inhibit the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. In addition, P210-Ab significantly attenuated macrophage infiltration and markedly improved the stability of atheromatous plaque. In conclusion, the anti-atherosclerotic effect of P210-Ab is related to its preferential inhibition of inflammation and reversion of cholesterol transportation by altering the pathway by which macrophages phagocytize ox-LDL., Competing Interests: None.