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1,456 results on '"Li, Zhi‐Yuan"'

153. Ultra-broadband flat-top quantum dot comb lasers

Author

Huang, Jing-Zhi, primary, Ji, Zi-Tao, additional, Chen, Jia-Jian, additional, Wei, Wen-Qi, additional, Qin, Jia-Le, additional, Wang, Zi-Hao, additional, Li, Zhi-Yuan, additional, Wang, Ting, additional, Xiao, Xi, additional, and Zhang, Jian-Jun, additional

Published
2022
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171. Negative Correlation between Bone Mineral Density and Fluoride Exposure in Chinese Adults: A Mediating Role for Total Antioxidant Capacity and Mitochondrial DNA Copy Number

Author

Ba, Yue, primary, Feng, Zichen, additional, Ma, Jun, additional, Du, Yuhui, additional, Gong, Yongxiang, additional, Guo, Meng, additional, Zhong, Yutong, additional, Liu, Xiaoxue, additional, Li, Zhi-yuan, additional, Huang, Hui, additional, Yu, Fangfang, additional, and Zhou, Guo-yu, additional

Published
2022
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193. Dual-omics reveals temporal differences in acute sympathetic stress-induced cardiac inflammation following α1and β-adrenergic receptors activation

Author

Zhang, Di, Zhao, Ming-ming, Wu, Ji-min, Wang, Rui, Xue, Gang, Xue, Yan-bo, Shao, Ji-qi, Zhang, You-yi, Dong, Er-dan, Li, Zhi-yuan, and Xiao, Han

Abstract

Sympathetic stress is prevalent in cardiovascular diseases. Sympathetic overactivation under strong acute stresses triggers acute cardiovascular events including myocardial infarction (MI), sudden cardiac death, and stress cardiomyopathy. α1-ARs and β-ARs, two dominant subtypes of adrenergic receptors in the heart, play a significant role in the physiological and pathologic regulation of these processes. However, little is known about the functional similarities and differences between α1- and β-ARs activated temporal responses in stress-induced cardiac pathology. In this work, we systematically compared the cardiac temporal genome-wide profiles of acute α1-AR and β-AR activation in the mice model by integrating transcriptome and proteome. We found that α1- and β-AR activations induced sustained and transient inflammatory gene expression, respectively. Particularly, the overactivation of α1-AR but not β-AR led to neutrophil infiltration at one day, which was closely associated with the up-regulation of chemokines, activation of NF-κB pathway, and sustained inflammatory response. Furthermore, there are more metabolic disorders under α1-AR overactivation compared with β-AR overactivation. These findings provide a new therapeutic strategy that, besides using β-blocker as soon as possible, blocking α1-AR within one day should also be considered in the treatment of acute stress-associated cardiovascular diseases.

Published
2023
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198. Rising Interest in the Development of Metal Complexes in Cancer Immunotherapy.

Author

Li, Zhi‐Yuan, Shen, Qing‐Hua, Mao, Zong‐Wan, and Tan, Cai‐Ping

Subjects
*PLATINUM, *METAL complexes, *PLATINUM group, *IMMUNOTHERAPY, *COPPER compounds, *IRIDIUM, *RUTHENIUM
Abstract

Metal complexes have shown great potential in cancer immunotherapy. This review briefly introduces the basic concepts and strategies of cancer immunotherapy and summarizes the recent discoveries on the immune effects of traditional platinum‐based anticancer compounds. In addition, we also outline the latest research progresses on metal complexes for cancer immunotherapy focusing on platinum, ruthenium, iridium, rhenium and copper complexes. Finally, the research perspectives and unsolved problems on the applications of metallo‐anticancer agents in cancer immunotherapy are purposed. [ABSTRACT FROM AUTHOR]

Published
2022
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