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This study investigates patterns of misuse and overuse of the te form in parallel clauses. The data were extracted from the YUK Tagged Corpus by Chinese learners of Japanese. The following results were obtained: (1) Overuse is likely to occur, as overuse appears about 12 times as much as non-use. However, as a stylistic tendency, there is a common feature concentrated on the da /dearu style. (2) Misuse patterns of overuse include 3 types and 5 categories. For example: parallel (“antecedent and consequent” and “separate presentation”), succession (“no continuity before or after”), and contrast (“lack of unity by theme” and “formal similarity”), but more than 60% are in parallel. (3) As for misuse patterns of non-use, there are patterns related to the predicate of the antecedent, such as“ function word expression” and“ one beat of the conjunctive form.” There are also things related to semantic use, such as the“ catching method of unity” and the“ causal relationship.” Non-use due to the“ catching method of unity” accounts for most misuse cases. (4) For overuse and non-use, there are many cases of misuse where the reading point is a formal tendency. This reading point indicates that the learner is aware there is a break before and after the reading point. At that time, overuse involves the te form plus the reading point, and the learner has a break between sections at the reading point. At the same time, both are connected by the te form, which represents them. Non-use indicates that the learner cannot judge a situation where “continuation of continuous use” and the te form are mixed, and the te form cannot be used., 本稿は，2018年度湖南省社科基金外语科学联合项目“日汉省略现象的认知对比研究”（課題番号:18WLH14）の助成を受けて行った研究成果の一部である。

Objective Existing agents to induce enamel self-repair and inhibit the progression of dental caries in the early stage have been proven to be inadequate and far from satisfactory. In this study, a honokiol-loaded poly(amido amine) (PAMAM) dendrimer (PAMH) was constructed to combat early caries lesions in enamel. Methods PAMH was prepared via a codissolution method. Computational simulation analysis was used to explore the mechanism of honokiol release. The cytotoxicity of PAMH was tested. The antibacterial effects of PAMH were tested by planktonic growth assays and biofilm formation inhibition assays. The remineralization effect of PAMH was examined via transverse microradiography and scanning electron microscopy after a pH cycling model. The in vivo anti-caries effect of PAMH was carried out in a rat model. Results Honokiol released from PAMH was slower but more durable in a cariogenic pH environment than in a neutral pH environment, which could be explained through the computational simulation analysis results. Under electrostatic action, P3 beads with the same charge repelled each other and extended outwards, resulting in the rapid expansion of the PAMAM dendrimer and accelerating the release of the drug. At a low pH of 5.5, the protonated P3 beads were not charged and the protonated P1 beads were positively charged. However, the electrostatic repulsive interaction between protonated P1 beads was restricted by the P3 beads in the outermost layer of the PAMAM dendrimer, so the swelling rate was relatively slow, resulting in the slow release of drug molecules in the acidic environment. The cytotoxicity demonstration and the biocompatibility experiment in animal study showed that PAMH is biologically safe. PAMH showed excellent enamel remineralizing ability after pH cycling and showed a long-term antibacterial effect in vitro. Meanwhile, PAMH showed long-term anticaries efficacy in vivo. Significance Our findings indicated that PAMH had great potential to combat early caries lesions in enamel for future clinical application.

BackgroundMaturity-onset diabetes of the young 5 (MODY5), a rare diabetes syndrome of young adults, is associated with variants in hepatocyte nuclear factor 1B (HNF1B) gene.Case PresentationWe reported a case of MODY5, which presented with diabetic ketosis, multiple renal cysts, and hypokalemia. In this case, the HNF1B score was estimated as 13 and a heterozygous variant of HNF1B in exon 4 (c.826C>T, p.Arg276*) was identified through Sanger sequencing.ConclusionsMultiple renal cysts and youth-onset diabetes are common manifestations in patients with HNF1B mutations, and insufficient insulin secretion may be a potential cause of diabetic ketosis in MODY5.

Large mode area (LMA) fibers are widely used in high power fiber lasers to solve the nonlinear problems. In this work, a Nd3+-doped phosphate glass LMA fiber with heterogeneous helical claddings (HHC) is fabricated successfully by rod in tube method for the first time. The performance of the preform glass was matched well and suitable for drawing the fiber, and the related fabrication method is helpful for other special structure fiber fabrication. The fiber performance such as loss and gain coefficients are both tested and compared respectively. The experiment results show that the loss coefficient α will increase with the decrease of Λ (helix pitch) or r (fiber core radius), furtherly, the net gain coefficient g will become larger with the increase of r or Λ. The experiment results are beneficial to the HHC fiber design furtherly. As the HHC fiber has an all-solid-state structure, it is easy to fabricate relatively and convenient for cutting, splicing, etc. Thus, the HHC fiber will have potential applications in the field of fiber lasers.

The critical information for conserving endangered species is to identify how different niche dimensions affect key life history stages of a population. However, it is often difficult to quantify how each ecological niche dimension affects different life history stages because environmental factors may affect each fitness component of organisms to various degrees. Here, we applied the recently developed hypervolume method that follows the idea of Hutchinson's n-dimensional hypervolume. We analyzed the niche space of different life history stages of the endangered landlocked salmon Oncorhynchus masou formosanus, the most southerly distributed of all salmonoids. We found no direct effect of water pollution on salmon population density but a significant negative effect on salmon reproductive success. Surprisingly, the niche hypervolume analysis showed that the size of hatching success niche hypervolume was only 17.9% and 18.4% of the natural redd site density or population density, respectively. This result demonstrates a much higher environmental requirement for salmon during the egg stage than that affecting population density or nesting environment. Our results suggest that understanding the behavioral and physiological mechanisms that influence crucial life history stages in the wild is critical to developing effective conservation programs, and the niche hypervolume is a valuable method to achieve this.

In this work, a one-dimensional waveguide is formed by virtue of the helium ion implantation in the oxyfluoride glass (OFG). The energy and the fluence of the ion implantation are 0.4 MeV and [Formula: see text] [Formula: see text], respectively. The m-line curve with the effective refractive indices of the modes was recorded by using the prism coupling system. The energy loss distribution and the refractive index profile were calculated by the stopping and range of ions into matter (SRIM)-2013 and the RCM, respectively. The light modal profile was measured by the end-facet coupling system. It suggests that the He[Formula: see text]-ion implanted OFG waveguides have the potential to act as integrated photonic devices.

The ridge waveguide on the TGG crystal has been fabricated through the combination of the ion implantation and the femtosecond laser ablation. Firstly, optical planar waveguide was formed on the to...

Melt processing is a promising process to fabricate Mg–CNTs (carbon nanotubes) composites with high performance and large dimensions. In this work, the liquid-mixing technique and ball-milling processes as well as the stirring casting method were used to prepare ZM1-1.0CNTs-L and ZM1-1.0CNTs-B composites, respectively. The composites were studied using optical microscopy (OM), Raman spectroscopy, scanning electron microscope (SEM), transmission electron microscope (TEM) and room-temperature tensile test. The results show that the yield strength (YS), ultimate tensile strength (UTS), elongation and microhardness values of the ZM1-1.0CNTs-L composite are improved by 37.3%, 29.6%, 37.0% and 33.3%, respectively, compared with those of ZM1 alloy. The uniform dispersion of CNTs as well as the strong interfacial bonds with the Mg matrix is the main reason for the significant improvement in mechanical properties of the as-cast composite. Liquid mixing combined with the stirring casting method is favorable to fabricate Mg–CNTs composite with high mechanical properties.

The work reports on the preparation and optical characterization of 75P2O5-15B2O3-9Al2O3-Bi2O3 glass by using the melt-quenching method and absorption spectroscopy, respectively. Further, 0.4-MeV proton implantation of a fluence of 8.0 × 1016 ions/cm2 was carried out on this glassy sample and it was tested as a waveguide at a wavelength of 632.8 nm for the first time to our knowledge. The m-line curves of the waveguide were measured before and after successive annealing treatments. The formation theory of the planar waveguides is discussed through simulations of the energy loss distribution and analysis of the reconstructed refractive index profile. The results should be useful in the design and fabrication of bismuth-doped phosphate glass and its use in integrated photonics devices.

This work reports on the fabrication and characterization of a K9 glass planar waveguide structure. The helium ion implantation was employed to form the waveguide on the K9 glass. The choices of the energy of 0.4 MeV and the dose of [Formula: see text] ions/cm2 were conducted by the SRIM 2013. The [Formula: see text]-line spectroscopy and the modal profile of the He[Formula: see text]-irradiated K9 glass waveguide were performed by the prism-coupling system and the end-face coupling technique at 0.6328 [Formula: see text]m, which suggests the capability of light propagation. The He[Formula: see text]-implanted K9 glass waveguides can serve as potential candidates for advanced integrated optoelectronic devices.