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Light emitting diode (LED) lighting provides an affordable lighting option for use in commercial poultry production. However, more information is needed to understand the effects of LED color on broiler welfare and growth. Five consecutive flocks (1 in summer, 1 in fall, 2 in winter, and 1 in spring) of straight run Ross 708 × Ross 708 broilers were reared in commercial type barns for 45 D. For white only (WO) treatment, birds were reared under white LED only (Agrishift MLB). For white supplemented (WS) treatment, birds were reared under white LED (Agrishift MLB) in the center aisle, with supplemental blue/green LED lighting (Agrishift MLBg) above the feed and water lines on either side of the barn. Each barn housed 26,200 chicks, and there were 2 barns in each treatment (n = 52,400/treatment). Treatments were rotated among barns between each flock. On day 45, blood samples were collected from 20 birds/barn (n = 40/treatment) to assess the plasma corticosterone (CORT) level and heterophil/lymphocyte ratio. On day 45, 100 birds/barn (n = 200/treatment) were weighed individually and assigned scores for hock burn and foot pad dermatitis. All measures were affected by trial (P

Background: recently much studies evidenced the potential role of photo-biomodulation (PBM) in patients affected by Age-related Macular Degeneration (AMD). We designed a new wearable device for self-medication that employs the same broadband red light described in literature, but with extremely low irradiance., Aim: to demonstrate the safety and effectiveness of low-fluence light stimulations emitted by a LED source with appropriate wavelengths through our new device in improving short-term visual function in patients affected by severe non neovascular AMD., Materials and Methods: we prospectively enrolled patients affected by severe non-neovascular AMD with a relative sparing of the foveal region. All the patients were randomly assigned in placebo or in treatment group. The treatment consisted of 10 sessions of 10-min each, using the new device comprised of micro-LEDs that emitted light onto an amorphous support assembled within Metallic eyeglasses. The placebo group blindly underwent the same number of PBM sessions with the micro-LED turned off. Before and after each placebo/treatment sessions all the patients received: optical coherence tomography (OCT), Best-Corrected Visual Acuity (BCVA) and Microperimetry (MP)., Results: no significant differences in the anatomical parameters were observed in the two groups. The MP mean sensitivity and the central visual function both far and near significantly improved in the treated group (respectively p  < 0.001, p  < 0.001)., Conclusions: our pivotal demonstrated that the LED PBM delivered through our new device is a safe and effective tool for improving short-term visual function in patients affected by severe non-neovascular AMD., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

An effective passive two-phase light-emitting diode (LED) cooling system using thermally cured graphene nanoplatelets (GNPs) coatings is introduced. The GNPs-coated surfaces demonstrate significant reduction in the static contact angle as compared to the uncoated aluminium surface. The ultrafast water permeation property of the micro/nano-capillaries-structured GNPs coatings engenders significant cooling performance enhancement of the LED. The water is absorbed by the GNPs coatings and permeating upwards against the gravitation force. The water molecules are propelled through the nanocapillaries formed by the carbon walls and the capillary force dominates over the gravitational force. This induces the filmwise evaporation on the GNPs-coated surfaces and significantly enhances the LED cooling. As compared to the uncoated case, a maximum heat transfer coefficient enhancement of 73% is achieved. The GNPs coatings also significantly lower the operating light emitting surface temperature up to 10 °C reduction, effectively removes potential hotspots which in turn optimise the LED functionality and durability. This study paves the way for the promising employment of thermally cured GNPs coatings in developing a passive phase-change heat transfer device for LED cooling.

Ultraviolet C (UVC) light emitting diode (LED) can kill the endodontic pathogen Enterococcus faecalis and has the potential to kill other oral microorganisms associated with endodontic infections. This same bacteriocidal device shows great promise in the stimulation of periapical healing and pain reduction resulting from inflammation in root canals. Previously, we found that 255 nm UVC LED killed E. faecalis and induced the production of cellular biomarkers in HEPM cells and gingival fibroblasts (Morio et al., 2019). Here, we extend those findings and hypothesize that UVC LED at other wavelengths and power levels kill microorganisms associated with root canal infections. Units emitting UVC LED at 265 nm (12 mW), 265 nm (22.5 mW), and 280 nm (8 mW) wavelenths were assembled and the energy levels of their emissions were measured. The energy doses in millijoules (mJ) were calculated from the power readings of the meter (µW) × time of exposure (seconds). Ex vivo models of root canals were prepared in extracted, instrumented, single canal human premolars. Five cultures of microorganisms were treated with 265 nm (12 mW), 265 nm (22.5 mW), or 280 nm (8 mW) UVC LED on discs in laboratory assays and 4 cultures of microorganisms were treated with 265 nm (22.5 mW) UVC LED in root canals of extracted, instrumented teeth. After UVC LED treatment, all microorganisms were cultivated on microbiological media. Colony forming units (CFU) of viable microorganisms treated with UVC LED were counted and compared with those of viable microorganisms not treated with UVC LED as controls. Tukey's Honestly Significant Difference was used to determine statistical significances (0.05). Units emitting UVC LED at 265 nm (12 mW), 265 nm (22.5 mW), and 280 nm (8 mW) killed Candida albicans, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), E. faecalis, and Streptococcus sanguinis after 30-90 seconds of exposure in laboratory assays (p

Leaves acclimate to day-to-day fluctuating levels of photosynthetic photon flux density (PPFD) by adjusting their morphological and physiological parameters. Accurate estimation of these parameters under day-to-day fluctuating PPFD conditions benefits crop growth modeling and light environment management in greenhouses, although it remains challenging. We quantified the relationships between day-to-day PPFD changes over 6 days and light acclimation parameters for cucumber seedling leaves, including leaf mass per area (LMA), chlorophyll (Chl) a/b ratio, maximum net photosynthetic rate (Pnmax), maximum rate of ribulose-1,5-bisphosphate (RuBP) carboxylase/oxygenase (Vcmax), and maximum rate of electron transport (Jmax). The last two parameters reflect the capacity of the photosynthetic partial reactions. We built linear regression models of these parameters based on average or time-weighted averages of daily PPFDs. For time-weighted averages of daily PPFDs, the influence of daily PPFD was given a specific weight. We employed three types of functions to calculate this weight, including linear, quadratic, and sigmoid derivative types. We then determined the trend of weights that estimated each parameter most accurately. Moreover, we introduced saturating functions to calibrate the average or time-weighted averages of daily PPFDs, considering that light acclimation parameters are usually saturated under high PPFDs. We found that time-weighted average PPFDs, in which recent PPFD levels had larger weights than earlier levels, better estimated LMA than average PPFDs. This suggests that recent PPFDs contribute more to LMA than earlier PPFDs. Except for the Chl a/b ratio, the average PPFDs estimated Pnmax, Vcmax, and Jmax with acceptable accuracy. In contrast, time-weighted averages of daily PPFDs did not improve the estimation accuracy of these four parameters, possibly due to their low response rates and plasticity. Calibrating functions generally improved estimation of Chl a/b ratio, Vcmax, and Jmax because of their saturating tendencies under high PPFDs. Our findings provide a reasonable approach to quantifying the extent to which the leaves acclimate to day-to-day fluctuating PPFDs, especially the extent of LMA.

Light is a fundamental cue regulating a host of biological responses. The artificial modification thereof demonstrably impacts a wide range of organisms. The use of artificial light is changing in type, extent and intensity. Insect vector-borne diseases remain a global scourge, but surprisingly few studies have directly investigated the interactions between artificial light and disease vectors, such as mosquitoes. Here we briefly overview the progress to date, which highlights that artificial light must be considered as a modulator of mosquito-borne disease risk. We discuss where the mechanisms may lie, and where future research could usefully be directed, particularly in advancing understanding of the biological effects of the light environment. Further understanding of how artificial light may modulate mosquito-borne disease risk may assist in employing and redesigning light regimes that do not increase, and may even mitigate, already significant disease burdens, especially in the developing world.

Leaves acclimate to day-to-day fluctuating levels of photosynthetic photon flux density (PPFD) by adjusting their morphological and physiological parameters. Accurate estimation of these parameters under day-to-day fluctuating PPFD conditions benefits crop growth modeling and light environment management in greenhouses, although it remains challenging. We quantified the relationships between day-to-day PPFD changes over 6 days and light acclimation parameters for cucumber seedling leaves, including leaf mass per area (LMA), chlorophyll (Chl) a / b ratio, maximum net photosynthetic rate (P nmax), maximum rate of ribulose-1,5-bisphosphate (RuBP) carboxylase/oxygenase (V cmax), and maximum rate of electron transport (J max). The last two parameters reflect the capacity of the photosynthetic partial reactions. We built linear regression models of these parameters based on average or time-weighted averages of daily PPFDs. For time-weighted averages of daily PPFDs, the influence of daily PPFD was given a specific weight. We employed three types of functions to calculate this weight, including linear, quadratic, and sigmoid derivative types. We then determined the trend of weights that estimated each parameter most accurately. Moreover, we introduced saturating functions to calibrate the average or time-weighted averages of daily PPFDs, considering that light acclimation parameters are usually saturated under high PPFDs. We found that time-weighted average PPFDs, in which recent PPFD levels had larger weights than earlier levels, better estimated LMA than average PPFDs. This suggests that recent PPFDs contribute more to LMA than earlier PPFDs. Except for the Chl a / b ratio, the average PPFDs estimated P nmax, V cmax, and J max with acceptable accuracy. In contrast, time-weighted averages of daily PPFDs did not improve the estimation accuracy of these four parameters, possibly due to their low response rates and plasticity. Calibrating functions generally improved estimation of Chl a / b ratio, V cmax, and J max because of their saturating tendencies under high PPFDs. Our findings provide a reasonable approach to quantifying the extent to which the leaves acclimate to day-to-day fluctuating PPFDs, especially the extent of LMA. [ABSTRACT FROM AUTHOR]

Recently, there has been considerable interest in establishing tree-rearing methods for breeding nursery trees, which are similar to the methods employed in plant factories to produce vegetables. Studies have shown that the efficiency of tree cultivation can be improved by changing the wavelength of the lighting that is used to raise young plants and that light emitting diodes (LEDs) are effective for this purpose. In this study, the effect of blue (450 nm), red (660 nm), and white (combination of blue and yellow (525 nm) LED lights was investigated for rearing Cryptomeria japonica saplings. 7 saplings with each LED were prepared and reared for 52 weeks in a constant environment chamber (Temperature: 23 ± 2 ºC, relative humidity 50% ± 10%), and their growth rates and root system morphology were compared. After 52 weeks of breeding, red light induced slightly more stem growth than white light. Blue light was nearly three times more effective in stem growth than white light. Furthermore, the wavelength of light affected the root system morphology. Many root branches were observed in saplings reared under red light, while marked taproot growth was observed in saplings reared under blue light. There was a possibility that saplings could be produced more efficiently by using LED. [ABSTRACT FROM AUTHOR]

An light-emitting bipolar transistor (LEBJT) has been developed in response to aspirations for on-chip electronics with GaN-based light-emitting diode (LED) devices. The design utilizes the existing p-n junction of an LED structure to construct a PNP bipolar junction transistor comprising two back-to-back p-n junctions, saving the need for customized structures or epitaxial regrowth. Two designs of monolithic GaN LEBJTs have been demonstrated in this workâ€"an LEBJT with a larger emitter area size for conversion of electronic to optical signal, as well as an LEBJT with reduced emitter area for boosting of current gain. Employing an emitter comprising an array of nanopillars patterned by nanosphere lithography, the LEBJT exhibits an average current gain of 20 and a bandwidth of 180 MHz. [ABSTRACT FROM AUTHOR]

As time gets advanced multiple progressions have happened in the field of display devices. In this field first came a small LED then after CRT (Cathode Ray Tube) which is used in present days but due to its heaviness, we do not carry it from one place to another. Then after came LCD (Liquid Crystal Display), the problem of bulkiness and required large area overcome by LCD, the only problem with LCD is that it cannot see a clear picture from different angles. LCD is a lightweight and flexible plastic substrate. After all these innovations OLED came and OLED beat all issues of LCD and CRT. OLED is light and slim in design, it does not require any kind of backlight, OLEDs are self-luminous. Polymers are using to fabricate OLEDs or unlike LCDs small molecules in the flat panel zone. It has low power consumption (only 2-10 volts) also OLEDs has a wide viewing angle (up to 160 degrees). The applications of OLEDs in electronics are on the increase on daily basis from camera to cell phones to OLED televisions. [ABSTRACT FROM AUTHOR]

During the last years, visible light communications (VLC) have been proposed for providing connectivity while ensuring satisfactory illumination in both indoor environments and also specific outdoor scenarios without the need of deploying complex infrastructures for that purpose. Transmission for VLC is carried out through light-emitting diodes (LEDs), which correspond to semiconductors based on PN-junction materials with a direct gap. In this sense, the current flow plays a major role in the behavior and performance of these devices for VLC. Therefore, characterizing the electrical response of high-power white LED results mandatory for the successful implementation of VLC. At this point, it is worth noting that the electrical characterization is usually not available for high-power LEDs since, in fact, determining these characterization results challenging. In this sense, there exist some measurement instruments such as LCRs or impedance analyzers typically employed for characterizing materials and passive electrical components. However, these kinds of instruments are subject to a limited input impedance and a maximum value of forwarding current. In this work, the electrical characterization of the LED LXHL-BW02 of Luxeon is analyzed to show that typically commercial instrumentation for characterizing these devices is limited for high-power LEDs, which may provide polluted results when these limitations are not considered. After that, the characterization of the LXHL-BW02 based on a lock-in amplifier is proposed.

To evaluate the potential toxicity of operation microscopes with halogen and light emitting diode (LED) light source on the rabbit eyes. Thirty-two eyes of 16 male New Zealand pigmented rabbits were involved in the study. The rabbits were divided into two groups according to the type of light source applied. Only one eye of each rabbit was exposed to illumination light, unexposed fellow eyes served as the control group. Experimental groups included group 1 exposed to halogen light for 2 h and evaluated 1 day and 1 week after the illumination, group 2 exposed to LED light for two hours and evaluated 1 day and 1 week after the illumination. On the first and seventh days after exposing the light, we evaluated the rabbit corneas using in vivo confocal microscopy (IVCM). At the end of the seventh day, the Hematoxylin-eosin staining and TUNEL staining were performed to investigate the presence of apoptosis in the retina and retina pigment epithelium. Early IVCM findings revealed corneal epithelial cell ovalization and indistinct intercellular borders in the halogen light group. We also observed more increase in the keratocyte density index (23.7% vs 14.1%, p = 0.001, respectively) and the Bowman reflectivity index (12.4% vs 4.1%, p = 0.001, respectively) at first day of the light exposure in halogen light group compared to LED light group. However, late IVCM indicated that these findings disappeared one week later. No apoptosis was observed in the corneal and retinal layers in early and late examination groups. The present experimental study demonstrated that both halogen and LED lights, which were commonly used for microscopic eye surgery, had no sustained adverse effect on the cornea and retina of the rabbits; however, halogen light had a temporary adverse effect on corneal epithelium and stroma, which resolved within 1 week. [ABSTRACT FROM AUTHOR]

This research paper discusses an analytical approach to designing the active region of light emitting diodes to enhance its performance. The layers in the active region were modified and the effects of changing the width of quantum well and barrier layers in a multiquantum light emitting diode on the output power and efficiency have been investigated. Also, the ratio of the quantum well width to the B layer width was calculated and proposed in this research paper. The study is carried out on two different LED structures. In the first case, the width of the quantum well layers is kept constant while the width of the B layers is varied. In the second case, both the quantum well and B layer widths are varied. Based on the simulation results, it has been observed that the LED power efficiency increases considerably for a given quantum well to B layers width ratio without increasing the production complexity. It is also seen that for a desired power efficiency the width of quantum well should be between 0.003 µm and 0.006 µm, and the range of B width (height) should be 2.2 to 6 times the quantum well width. The proposed study is carried out on the GaN-AlGaN-based multi-quantum well LED structure, but this study can be extended to multiple combinations of the semiconductor structures. [ABSTRACT FROM AUTHOR]

Light-emitting diodes (LEDs) are modulated using a square wave pulse sequence for flicker prevention and dimming control in visible light communication (VLC). In a VLC transmitter, the high and low bits of the non-return-to-zero (NRZ) data are converted to two square waves of different frequencies, which continue for a finite time defined by the fill ratio in an NRZ bit time. As the average optical power was kept constant and independent of data transmission, the LED was flicker-free. Dimming control is carried out by changing the fill ratio of the square wave in the NRZ bit time. In the experiments, the illumination of the LED light was controlled in the range of approximately 19.2% to 96.2% of the continuous square wave modulated LED light. In the VLC receiver, a high-pass filter combined with a latch circuit was used to recover the transmitted signal while preventing noise interference from adjacent lighting lamps. [ABSTRACT FROM AUTHOR]

Mn4+‐activated deep red‐emitting SrLaLiTeO6 phosphors are investigated for indoor plant growth LED applications for the first time. The phosphors crystallize in monoclinic (P21/n) symmetry is isostructural with SrLaLiTeO6 host. B‐site substitution of Mn4+ ions is confirmed from the redshift of high energy phonon modes in both Raman and IR spectra. The phosphor exhibited a far‐red emission centered at 696 nm corresponding to the 2Eg → 4A2g spin‐forbidden transition of the Mn4+ ions. Approximate crystal field parameters depict the weak influence of neighboring ligand fields on Mn4+ ions and the least covalence of Mn4+‐ligand bonding compared to other double perovskite phosphors. Moreover, the phosphors exhibit excellent thermal stability with an activation energy of 0.23 eV. Phosphor parameters including CCT, color purity, and quantum yield are evaluated and their values meet the requirements of a red‐emitting phosphor for LED applications. Furthermore, the PL emission spectrum of SrLaLiTeO6: Mn4+ matches with the absorption spectrum of plant phytochromes denoting the prospects of this phosphor for indoor plant growth LED applications. [ABSTRACT FROM AUTHOR]

The introduction of artificial light at night (ALAN) into natural and urbanised landscapes is a known and highly pervasive disruptor of invertebrate communities. However, the effect of variation in intensity and spectra of ALAN on invertebrate communities inhabiting different spatial niches is little understood. Further, the remarkable ability of ALAN to continue to disrupt biodiversity even in chronically illuminated urban landscapes is not often acknowledged.Here, we simultaneously sampled airborne and ground‐dwelling invertebrate assemblages under and between urban street lights to explore the effects on community composition and abundance of (a) proximity to decadal (i.e. long‐illuminated) nocturnal street lighting and (b) variation in the spectral output of light.The two assemblages responded differently. For airborne invertebrates, night‐time abundance doubled, and night‐time assemblage composition was significantly different for traps under, compared with between, street lights. These differences in abundance were not affected by street light intensity, and were absent in day samples, suggesting that even weak ALAN may be causing short‐term redistribution of nocturnal invertebrates. Further, the abundance (but not composition) effects of ALAN on airborne invertebrates increased when the street lights emitted a higher proportion of short‐wavelength light.In contrast, for ground‐dwelling invertebrates, we found only marginal effects of proximity and spectrum of lighting on abundance and no effect on assemblage composition. However, more intense street lighting reduced abundance and altered composition at traps both under and between lights.Synthesis and Applications. Public lighting managers must consider ALAN impacts on invertebrate communities not only when introducing ALAN to naïve environments, but also when changing lighting in areas that are highly urbanised and exposed to decades of ALAN. Further, lighting proposals and environmental monitoring of invertebrate communities must take into account the effects on both ground‐dwelling and airborne assemblages, as these may respond very differently to the presence, intensity and spectrum of ALAN. [ABSTRACT FROM AUTHOR]

In this paper, a numerical model is used to analyze photovoltaic parameters according to the electronic properties of InGaN/GaN multiple-quantum-well light emitting diode (MQWLED) under hydrostatic pressure. Finite difference techniques have been used to acquire energy eigenvalues and their corresponding eigenfunctions of InGaN/GaN MQWLED and the hole eigenstates are calculated via a 6 × 6 k.p method under applied hydrostatic pressure. All symmetry-allowed transitions up to the fifth subband of the quantum wells (multi-subband model) are considered. The linewidth due to the carrier-carrier and carrier-longitudinal optical phonon scattering are also considered. A change in pressure up to 10 GPa increases the intraband scattering time up to 38 fs for heavy holes and 40 fs for light holes, raises the height of the Lorentz function, reduces the excitonic binding energy, and decreases the spontaneous emission rate up to 1.12 × 10 26 cm - 3 s - 1 eV - 1 and radiative current density up to 75 A / cm 2 . The multi-subband model has a positive effect on the radiative recombination rate. [ABSTRACT FROM AUTHOR]

Visible light (VL) indoor positioning offers significant advantages, such as low cost, high durability, and environmental protection. In this work, a phase difference-based VL positioning (VLP) system is presented. It uses the fast Fourier transform to accelerate the computation of the phase differences between the received signals. Furthermore, unlike most similar published works, it addresses the crucial issue of synchronization that arises in any system based on the time difference of arrival or phase difference and it proposes a technique to solve it. Compared with current indoor positioning methods using light-emitting diode (LED) light, our method has the advantage of having a high positioning accuracy, while being simple to implement and low cost. By means of simulations, we studied the impact on its performance of the choice of its design parameters, such as the values of frequencies assigned to different LEDs, the sampling frequency, the power of noise, and the lack of synchronization. The obtained results show that an appropriate choice of these parameters achieves high-accuracy positioning. Using only three LEDs, an average error of 0.59 cm could be achieved over a testing area of 100 cm×100 cm×160 cm , for a signal-to-noise ratio equal to 15 dB. [ABSTRACT FROM AUTHOR]

Abstract Gafchromic external beam therapy 3 (EBT3) film has widely been used in medical field applications. Principally, the EBT3 film’s color gradually changes from light green to darker color under incremental exposures by ionizing or even non-ionizing ultraviolet (UV) radiation. Peak absorbance of the EBT3 film can be used to predict absorbed doses by the film. However, until today, related researches still rely on spectrometers for color analysis of EBT3 films. Hence, this paper presents a comparative analysis between results produced by the spectrometer and a much simpler light-emitting diode-photodiode based system in profiling the color changes of EBT3 films after exposure by solar UV radiation. This work has been conducted on a set of 50 EBT3 samples with incremental solar UV exposure (doses). The wavelength in the red region has the best sensitivity in profiling the color changes of EBT3 films for low solar UV exposure measurement. This study foresees the ability of blue wavelength to profile films with a large range of solar UV exposure. The LED (light emitting diode)-based optical system has produced comparable measurement accuracies to the spectrometer and thus, with a potential for replacing the need for a multipurpose spectroscopy system for simple measurement of light attenuation.

Abstract Background Skin fibrosis is a significant global health problem that affects over 100 million people annually and has a profoundly negative impact on quality of life. Characterized by excessive fibroblast proliferation and collagen deposition, skin fibrosis underlies a wide spectrum of dermatologic conditions ranging from pathologic scars secondary to injury (e.g., burns, surgery, trauma) to immune-mediated diseases. Effective anti-scarring therapeutics remain an unmet need, underscoring the importance of developing novel approaches to treat and prevent skin fibrosis. Our in vitro data show that light emitting diode-red light (LED-RL) can modulate key cellular and molecular processes involved in skin fibrosis. In two phase I clinical trials (STARS 1 and STARS 2), we demonstrated the safety and tolerability of LED-RL at fluences of 160 J/cm2 up to 480 J/cm2 on normal human skin. Methods/design CURES (Cutaneous Understanding of Red-light Efficacy on Scarring) is a dose-ranging, randomized, parallel group, split-face, single-blind, mock-controlled phase II study to evaluate the efficacy of LED-RL to limit post-surgical skin fibrosis in subjects undergoing elective mini-facelift surgery. Thirty subjects will be randomly allocated to three treatment groups to receive LED-RL phototherapy or temperature-matched mock irradiation (control) to either periauricular incision site at fluences of 160 J/cm2, 320 J/cm2, or 480 J/cm2. Starting one week post-surgery (postoperative days 4–8), treatments will be administered three times weekly for three consecutive weeks, followed by efficacy assessments at 30 days, 3 months, and 6 months. The primary endpoint is the difference in scar pliability between LED-RL-treated and control sites as determined by skin elasticity and induration measurements. Secondary outcomes include clinical and photographic evaluations of scars, 3D skin imaging analysis, histological and molecular analyses, and adverse events. Discussion LED-RL is a therapeutic modality of increasing importance in dermatology, and has the potential to limit skin fibrosis clinically by decreasing dermal fibroblast activity and collagen production. The administration of LED-RL phototherapy in the early postoperative period may optimize wound healing and prevent excessive scarring. The results from this study may change the current treatment paradigm for fibrotic skin diseases and help to pioneer LED-RL as a safe, non-invasive, cost-effective, portable, at-home therapy for scars. Trial registration ClinicalTrials.gov, NCT03795116. Registered on 20 December 2018.

ight emitting diodes based on gallium arsenide-phosphide solid solutions were studied. Negative differential resistance regions were identified at lower temperatures T ≤ 130 K. Irradiation of diodes by electrons (E = 2 MeV) leads to the increase in the differential resistance, change in the contact potential difference, and a drop in the radiation intensity. These effects are due to the influence of deep radiation defects levels and surface states, activated by high levels of the ionization excitation peculiar to electron irradiation.

This study aimed to identify the near-infrared (NIR) light emitting diode (LED) time response on isokinetic peak torque of elbow flexors. This was a prospective, randomized, single blind, pre–test post-test, and placebo-controlled crossover study. Forty-five healthy non-athletes were assigned at random to 3 groups equally: 5 minutes, 1-hour and 5-hours groups. Each group (n=15) had at the first session 890 nm wavelength NIR-LED, either in active or placebo conditions, prior to exercise that provokes fatigue (5 minutes, 1 hour, or 5 hours). After an interval of 7 days, the second NIR-LED condition was applied at the second session. The assessment of isokinetic peak torque was done at base line and post exercise in each session using isokinetic dynamometer. There was no significant difference between groups and between conditions in isokinetic peak torque (p > 0.05). Isokinetic peak torque decreased significantly post treatment compared with pretreatment (p < 0.01) in all groups, but the 5 minutes group showed the least percent of decrease. In conclusion, NIR-LED can most probably resist muscle fatigue with the parameters used in this study if it is employed 5 minutes before exercise.

High market price and low availability of local winter and spring production has stimulated production of blackberries in glasshouses at northern latitudes. For this production, light is the main limiting factor. We investigated the potential of intercanopy lighting (ICL) using light emitting diodes (LEDs) to improve blackberry fruit yield in a crop with a spring and an autumn production cycle. During the spring production cycle three light treatments were applied: only natural light (no ICL), 93 or 185 μmol m–2 s–1 ICL In summer the lateral shoots were cut back and 93 μmol m–2 s–1 ICL was applied to all plants after cutting back, investigating a possible carryover effect of supplemental light in spring on autumn production. Fresh fruit yield in spring increased by 79 and 122% with 93 and 185 μmol m–2 s–1 ICL, respectively, compared to no ICL. This represents 3.6 and 2.8% increase in harvestable product for every additional 1% of light. A yield component analysis and leaf photosynthesis measurements were conducted. Maximum photosynthetic capacity (Amax) for leaves at 185 μmol m–2 s–1 ICL was about 50% higher, and LAI was 41% higher compared to no ICL. ICL increased the number of fruiting laterals per cane, and this explained 75% of the increase in yield. ICL at 185 μmol m–2 s–1 resulted in a higher yield compared to no ICL, primarily as a result of higher total dry matter production. Furthermore, a higher fraction of dry matter partitioned to the fruits (0.59 compared to 0.52) contributed to yield increase, whereas fruit dry matter content and fruit quality (sugar and acid content) was not affected by ICL. Averaged over the three light treatments autumn yield was 47% lower than spring yield. Autumn yield was 10% higher for plants at ICL 93 μmol m–2 s–1 in spring and 36% higher for plants at 185 μmol m–2 s–1 in spring compared to no ICL in spring. This increased autumn yield was caused by more fruiting laterals (less necrotic buds). It is concluded that management practices in spring can have a carryover effect on the autumn production. This is the first scientific paper on the potential for applying LED ICL in blackberries. Further research should focus on optimal intensity of ICL, positioning of supplementary lighting and economic feasibility.

Dry eye disease is one of the most common, chief-complaints presenting in clinical practice, with a prevalence of up to 50%. Evaporative dry eye, as a result of meibomian gland dysfunction, is thought to be the biggest component factor. Treatments for meibomian gland dysfunction aim to restore tear film homoeostasis and include warm compress therapy, eyelid hygiene, in-office meibomian gland expression and lipid-containing, artificial tears. A recent introduction to the in-office treatments available for meibomian gland dysfunction has been low-level light therapy, also known as photobiomodulation. The technique involves applying red, or near infra-red, radiation using low-power light sources and is suggested to promote tissue repair, decrease inflammation, and relieve pain. This work aims to review the available literature on the efficacy and safety of photobiomodulation in meibomian gland dysfunction and dry eye disease, as well as what is currently known about its mechanism of action. [ABSTRACT FROM AUTHOR]

Visible light positioning (VLP) is a cost-effective solution to the increasing demand for real-time indoor positioning. However, owing to high computational costs and complicated image processing procedures, most of the existing VLP systems fail to deliver real-time positioning ability and better accuracy for image sensor-based large-area indoor environments. In this study, an effective method is proposed to receive coordinate information from multiple light-emitting diode (LED) lights simultaneously. It provides better accuracy in large experimental areas with many LEDs by using a smartphone-embedded image sensor as a terminal device and the existing LED lighting infrastructure. A flicker-free frequency shift on–off keying line coding modulation scheme was designed for the positioning system to ensure a constant modulated frequency. We tested the performance of the decoding accuracy with respect to vertical and horizontal distance, which utilizes a rolling shutter mechanism of a complementary metal-oxide-semiconductor image sensor. The experimental results of the proposed positioning system can provide centimeter-level accuracy with low computational time, rendering it a promising solution for the future direction of large-area indoor positioning systems. [ABSTRACT FROM AUTHOR]

Background: Although evidence of both beneficial and adverse biological effects of lighting has accumulated, biologically favorable lighting often does not match subjectively comfortable lighting. By controlling the correlated color temperature (CCT) of ambient lights, we investigated the feasibility of combined lighting that meets both biological requirements and subjective comfort. Methods: Two types of combined lightings were compared; one consisted of a high-CCT (12000 K) light-emitting diode (LED) panel as the ambient light and a low-CCT (5000 K) LED stand light as the task light (high-low combined lighting), and the other consisted of a low-CCT (4500 K) LED panel as the ambient light and the same low-CCT (5000 K) stand light as the task light (low-low combined lighting) as control. Ten healthy subjects (5 young and 5 elderly) were exposed to the two types of lighting on separate days. Autonomic function by heart rate variability, psychomotor performances, and subjective comfort were compared. Results: Both at sitting rest and during psychomotor workload, heart rate was higher and the parasympathetic index of heart rate variability was lower under the high-low combined lighting than the low-low combined lighting in both young and elderly subject groups. Increased psychomotor alertness in the elderly and improved sustainability of concentration work performance in both age groups were also observed under the high-low combined lighting. However, no significant difference was observed in the visual-analog-scale assessment of subjective comfort between the two types of lightings. Conclusions: High-CCT ambient lighting, even when used in combination with low-CCT task lighting, could increase autonomic and psychomotor arousal levels without compromising subjective comfort. This finding suggests the feasibility of independent control of ambient and task lighting as a way to achieve both biological function regulation and subjective comfort. [ABSTRACT FROM AUTHOR]

Photobiomodulation using light-emitting diode (LED) treatment has analgesic and anti-inflammatory effects which can be an effective therapeutic associated with serum therapy for local treatment of snakebites. Here we explored the effects of LED treatment on isolated macrophage under Bothrops jararacussu venom. Results showed that LED induced IL-6 and TNF-α genes down-regulation and, TGF and ARG1 genes up-regulation which indicates a polarization of macrophages to an M2 phenotype contributing to both tissue repair and resolution of inflammation. [Display omitted] • Light Emitting Diode treatment induced the macrophage polarization toward a M2 phenotype under B. jararacussu venom action. • Light Emitting Diode treatment did not interfere with phagocytosis by macrophages under B. jararacussu venom action. • Light Emitting Diode treatment did not impede with macrophages lipid droplets formation under B. jararacussu venom action. [ABSTRACT FROM AUTHOR]

High market price and low availability of local winter and spring production has stimulated production of blackberries in glasshouses at northern latitudes. For this production, light is the main limiting factor. We investigated the potential of intercanopy lighting (ICL) using light emitting diodes (LEDs) to improve blackberry fruit yield in a crop with a spring and an autumn production cycle. During the spring production cycle three light treatments were applied: only natural light (no ICL), 93 or 185 μmol m–2 s–1 ICL In summer the lateral shoots were cut back and 93 μmol m–2 s–1 ICL was applied to all plants after cutting back, investigating a possible carryover effect of supplemental light in spring on autumn production. Fresh fruit yield in spring increased by 79 and 122% with 93 and 185 μmol m–2 s–1 ICL, respectively, compared to no ICL. This represents 3.6 and 2.8% increase in harvestable product for every additional 1% of light. A yield component analysis and leaf photosynthesis measurements were conducted. Maximum photosynthetic capacity (A max) for leaves at 185 μmol m–2 s–1 ICL was about 50% higher, and LAI was 41% higher compared to no ICL. ICL increased the number of fruiting laterals per cane, and this explained 75% of the increase in yield. ICL at 185 μmol m–2 s–1 resulted in a higher yield compared to no ICL, primarily as a result of higher total dry matter production. Furthermore, a higher fraction of dry matter partitioned to the fruits (0.59 compared to 0.52) contributed to yield increase, whereas fruit dry matter content and fruit quality (sugar and acid content) was not affected by ICL. Averaged over the three light treatments autumn yield was 47% lower than spring yield. Autumn yield was 10% higher for plants at ICL 93 μmol m–2 s–1 in spring and 36% higher for plants at 185 μmol m–2 s–1 in spring compared to no ICL in spring. This increased autumn yield was caused by more fruiting laterals (less necrotic buds). It is concluded that management practices in spring can have a carryover effect on the autumn production. This is the first scientific paper on the potential for applying LED ICL in blackberries. Further research should focus on optimal intensity of ICL, positioning of supplementary lighting and economic feasibility. [ABSTRACT FROM AUTHOR]

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Cannabis sativa L. is cultivated for its secondary metabolites, of which the cannabinoids have documented health benefits and growing pharmaceutical potential. Recent legal cannabis production in North America and Europe has been accompanied by an increase in reported findings for optimization of naturally occurring and synthetic cannabinoid production. Of the many environmental cues that can be manipulated during plant growth in controlled environments, cannabis cultivation with different lighting spectra indicates differential production and accumulation of medically important cannabinoids, including Δ9-tetrahydrocannabinol (Δ9-THC), cannabidiol (CBD), and cannabigerol (CBG), as well as terpenes and flavonoids. Ultraviolet (UV) radiation shows potential in stimulating cannabinoid biosynthesis in cannabis trichomes and pre-harvest or post-harvest UV treatment merits further exploration to determine if plant secondary metabolite accumulation could be enhanced in this manner. Visible LED light can augment THC and terpene accumulation, but not CBD. Well-designed experiments with light wavelengths other than blue and red light will provide more insight into light-dependent regulatory and molecular pathways in cannabis. Lighting strategies such as subcanopy lighting and varied light spectra at different developmental stages can lower energy consumption and optimize cannabis PSM production. Although evidence demonstrates that secondary metabolites in cannabis may be modulated by the light spectrum like other plant species, several questions remain for cannabinoid production pathways in this fast-paced and growing industry. In summarizing recent research progress on light spectra and secondary metabolites in cannabis, along with pertinent light responses in model plant species, future research directions are presented.

The metabolism of a building can be connected to a rooftop greenhouse, exchanging energy, water and CO2 flows, therefore reducing emissions and recycling cultivation inputs. However, integrating a rooftop greenhouse onto a building requires the application of stringent safety codes (e.g., fire, seismic codes), to strengthen and secure the structure with safety elements such as thick steel pillars or fireproof covering materials. These elements can shade the vegetation or reduce solar radiation entering the rooftop greenhouse. Nevertheless, application of additional LED light can help to overcome this constraint. The present study evaluated supplemental LED light application in an integrated rooftop greenhouse (i-RTG) at the ICTA-UAB research institute, located in Barcelona (Spain), for tomato cultivation (Solanum lycopersicum cv. Siranzo). The experiment explored the effects of three LED lighting treatments and a control cultivated under natural light only (CK). Applied treatments, added to natural sunlight, were: red and blue (RB), red and blue + far-red (FR) for the whole day, and red and blue + far-red at the end-of-day (EOD), each for 16 h d−1 (8 a.m.–12 a.m.) with an intensity of 170 µmol m−2 s−1. The results indicate that LED light increased the overall yield by 17% compared with CK plants. In particular, CK tomatoes were 9.3% lighter and 7.2% fewer as compared with tomatoes grown under LED treatments. Fruit ripening was also affected, with an increase of 35% red proximal fruit in LED-treated plants. In conclusion, LED light seems to positively affect the development and growth of tomatoes in building integrated agriculture in the Mediterranean area.

A monolithic thin film red light emitting diode (LED) active-matrix (AM) micro-display driven by a complementary metal-oxide semiconductor (CMOS) driver is demonstrated. The resolution of the micro-display is 64 × 36, with a 40 μm × 40 μm pixel pitch. Starting from AlGaInP epi-layers grown on GaAs substrates, the monolithic red LED array was fabricated and then integrated with the AM driver using Au/In flip-chip bonding technology. After removal of the GaAs substrate, a crack-free thin film micro-display was realized with a high pixel yield. The thin film red LED AM micro-display delivers a luminance of 2.35 × 104 cd/m2 at full-load conditions and can render images with 4-bit grayscale. This work not only provides a manufacturing-friendly approach for monolithic thin film red LED micro-displays, but also brings the possibility of hybrid integration with blue/green LEDs to achieve full-color LED micro-displays. [ABSTRACT FROM AUTHOR]

We propose a statistical adaptive equalizer to simultaneously transmit a discrete multitone signal encoded by quadrature phase shift keying and non-return-to-zero on–off keying in an optical wireless link based on a white light emitting diode. We implemented a white light emitting diode based optical wireless link with 1 m transmission distance and 10 MHz physical frequency response to experimentally verify the proposed technique. Using the implemented optical wireless link, 10-Mbit/s non-return-to-zero on–off keying and 20-Mbit/s quadrature phase shift keying signals were successfully simultaneously transmitted. Thus, transmission capacity corresponding to three times the optical wireless link frequency response (10 MHz) was implemented using the proposed technique. [ABSTRACT FROM AUTHOR]

Peak-to-average power ratio reduction techniques for visible light communication broadcasting systems are designed, simulated, and evaluated in this work. The proposed techniques are based on merging non-linear companding techniques with precoding techniques. This work aims to nominate an optimum novel scheme combining the low peak-to-average power ratio with the acceptable bit error rate performance. Asymmetrically clipped optical orthogonal frequency division multiplexing with the low peak-to-average power ratio performance becomes more attractive to real-life visible light communication applications due to non-linearity elimination. The proposed schemes are compared and an optimum choice is nominated. Comparing the presented work and related literature reviews for peak-to-average power ratio reduction techniques are held to ensure the proposed schemes validity and effectiveness. [ABSTRACT FROM AUTHOR]

Cannabis sativa L. is cultivated for its secondary metabolites, of which the cannabinoids have documented health benefits and growing pharmaceutical potential. Recent legal cannabis production in North America and Europe has been accompanied by an increase in reported findings for optimization of naturally occurring and synthetic cannabinoid production. Of the many environmental cues that can be manipulated during plant growth in controlled environments, cannabis cultivation with different lighting spectra indicates differential production and accumulation of medically important cannabinoids, including Δ9-tetrahydrocannabinol (Δ9-THC), cannabidiol (CBD), and cannabigerol (CBG), as well as terpenes and flavonoids. Ultraviolet (UV) radiation shows potential in stimulating cannabinoid biosynthesis in cannabis trichomes and pre-harvest or post-harvest UV treatment merits further exploration to determine if plant secondary metabolite accumulation could be enhanced in this manner. Visible LED light can augment THC and terpene accumulation, but not CBD. Well-designed experiments with light wavelengths other than blue and red light will provide more insight into light-dependent regulatory and molecular pathways in cannabis. Lighting strategies such as subcanopy lighting and varied light spectra at different developmental stages can lower energy consumption and optimize cannabis PSM production. Although evidence demonstrates that secondary metabolites in cannabis may be modulated by the light spectrum like other plant species, several questions remain for cannabinoid production pathways in this fast-paced and growing industry. In summarizing recent research progress on light spectra and secondary metabolites in cannabis, along with pertinent light responses in model plant species, future research directions are presented. [ABSTRACT FROM AUTHOR]

Light emitting diodes (LEDs) now enable precise light quality control. Prior to commercialisation however, the plant response to the resultant light quality regime ought to be addressed. The response was examined here in chrysanthemum by evaluating growth, chlorophyll fluorescence (before and following water deficit), as well as stomatal anatomy (density, size, pore dimensions and aperture heterogeneity) and closing ability. Plants were grown under blue (B), red (R), a mixture of R (70%) and B (RB), or white (W; 41% B, 39% intermediate spectrum, 20% R) light LEDs. Although R light promoted growth, it also caused leaf deformation (epinasty) and disturbed the photosynthetic electron transport system. The largest stomatal size was noted following growth under B light, whereas the smallest under R light. The largest stomatal density was observed under W light. Monochromatic R light stimulated both the rate and the degree of stomatal closure in response to desiccation compared with the other light regimes. We conclude that stomatal size is mainly controlled by the B spectrum, whereas a broader spectral range is important for determining stomatal density. Monochromatic R light enhanced stomatal ability to regulate water loss upon desiccation. In indoor horticulture, light quality can be precisely controlled. The chosen light quality regime affects both visual appearance and desiccation tolerance of ornamentals. By adjusting light regime during growth the quality of the ornamentals can be improved. [ABSTRACT FROM AUTHOR]

Light energy is harnessed for therapeutic use in a number of ways, most recently by way of photobiomodulation (PBM). This phenomenon is a cascade of physiological events induced by the nonthermal exposure of tissue to light at the near infrared end of the visible spectrum. Therapeutic PBM has become a highly commercialized interest, marketed for everything from facial rejuvenation to fat loss, and diode-based devices are popular in both the clinic setting and for use at home. The lack of regulatory standards makes it difficult to draw clear conclusions about efficacy and safety but it is crucial that we understand the theoretical basis for PBM, so that we can engage in an honest dialogue with our patients and design better clinical studies to put claims of efficacy to the test. This article presents a summary of the science of PBM and examines the differences between laser light, on which much of the preclinical evidence is based and light from diodes, which are typically used in a clinical setting. [ABSTRACT FROM AUTHOR]