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784 results on '"Low, Adrian"'

157. Sleep study guided multidisciplinary therapy for acute coronary syndrome: a randomized trial

Author

Lee, Chi-Hang Ronald, primary, Koo, Chieh–yang, additional, Kristanto, William, additional, Koh, Esther Hui–ting, additional, Tan, Eugene Siang–joo, additional, Abd Rahman, Shaffinaz, additional, Abd Gani, Munirah Binte, additional, Chong, Jenny Pek–ching, additional, Aung, Aye–thandar, additional, Han, Tun–oo, additional, Chan, Siew–pang, additional, Low, Adrian F., additional, Yeo, Tiong–cheng, additional, Chan, Mark Y., additional, Kojodjojo, Pipin, additional, Richards, Arthur Mark, additional, and Chua, Ai–ping, additional

Published
2019
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159. VAT Guide For Insurance In UAE: What You Should Know

Author

Low, Adrian

Subjects
Insurance industry -- International economic relations -- Taxation -- Laws, regulations and rules, Value-added tax -- Laws, regulations and rules, Government regulation, Insurance industry, Business, international
Abstract

After a period of much debate as to the application of VAT in the re/insurance industry in the UAE, the UAE Federal Tax Authority (FTA) has provided some clarification in [...]

Published
2018

160. Aging syndrome genes and premature coronary artery disease

Author

Chae Claudia U, Everett Brendan, Kathiresan Sekar, O'Donnell Christopher J, Low Adrian F, Shaw Stanley Y, Ellinor Patrick T, and MacRae Calum A

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Vascular disease is a feature of aging, and coronary vascular events are a major source of morbidity and mortality in rare premature aging syndromes. One such syndrome is caused by mutations in the lamin A/C (LMNA) gene, which also has been implicated in familial insulin resistance. A second gene related to premature aging in man and in murine models is the KLOTHO gene, a hypomorphic variant of which (KL-VS) is significantly more common in the first-degree relatives of patients with premature coronary artery disease (CAD). We evaluated whether common variants at the LMNA or KLOTHO genes are associated with rigorously defined premature CAD. Methods We identified 295 patients presenting with premature acute coronary syndromes confirmed by angiography. A control group of 145 patients with no evidence of CAD was recruited from outpatient referral clinics. Comprehensive haplotyping of the entire LMNA gene, including the promoter and untranslated regions, was performed using a combination of TaqMan® probes and direct sequencing of 14 haplotype-tagging single nucleotide polymorphisms (SNPs). The KL-VS variant of the KLOTHO gene was typed using restriction digest of a PCR amplicon. Results Two SNPs that were not in Hardy Weinberg equilibrium were excluded from analysis. We observed no significant differences in allele, genotype or haplotype frequencies at the LMNA or KLOTHO loci between the two groups. In addition, there was no evidence of excess homozygosity at the LMNA locus. Conclusion Our data do not support the hypothesis that premature CAD is associated with common variants in the progeroid syndrome genes LMNA and KLOTHO.

Published
2005
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162. Quantification of effects of mean blood pressure and left ventricular mass on noninvasive fast fractional flow reserve.

Author

Jun-Mei Zhang, Chandola, Gaurav, Ru-San Tan, Ping Chai, Teo, Lynette L. S., Low, Ris, Allen, John Carson, Weimin Huang, Jiang Ming Fam, Chee Yang Chin, Lung Wong, Aaron Sung, Low, Adrian F., Kassab, Ghassan S., Chua, Terrance, Tan, Swee Yaw, Soo Teik Lim, and Liang Zhong

Abstract

Proper inlet boundary conditions are essential for accurate computational fluid dynamics (CFD) modeling. We developed methodology to derive noninvasive FFRB using CFD and computed tomography coronary angiography (CTCA) images. This study aims to assess the influence of brachial mean blood pressure (MBP) and total coronary inflow on FFRB computation. Twenty-two patients underwent both CTCA and FFR measurements. Total coronary flow was computed from left ventricular mass (LVM) measured from CTCA. A total of 286 CFD simulations were run by varying MBP and LVM at 70, 80, 90, 100, 110, 120, and 130% of the measured values. FFRB increased with incrementally higher input values of MBP: 0.78 ± 0.12, 0.80 ± 0.11, 0.82 ± 0.10, 0.84 ± 0.09, 0.85 ± 0.08, 0.86 ± 0.08, and 0.87 ± 0.07, respectively. Conversely, FFRB decreased with incrementally higher inputs value of LVM: 0.86 ± 0.08, 0.85 ± 0.08, 0.84 ± 0.09, 0.84 ± 0.09, 0.83 ± 0.10, 0.83 ± 0.10, and 0.82 ± 0.10, respectively. Noninvasive FFRB calculated using measured MBP and LVM on a total of 30 vessels was 0.84 ± 0.09 and correlated well with invasive FFR (0.83 ± 0.09) (r = 0.92, P < 0.001). Positive association was observed between FFRB and MBP input values (mmHg) and negative association between FFRB and LVM values (g). Respective slopes were 0.0016 and −0.005, respectively, suggesting potential application of FFRB in a clinical setting. Inaccurate MBP and LVM inputs differing from patient-specific values could result in misclassification of borderline ischemic lesions. NEW & NOTEWORTHY While brachial mean blood pressure (MBP) and left ventricular mass (LVM) measured from CTCA are the two CFD simulation input parameters, their effects on noninvasive fractional flow reserve (FFRB) have not been systematically investigated. We demonstrate that inaccurate MBP and LVM inputs differing from patient-specific values could result in misclassification of borderline ischemic lesions. This is important in the clinical application of noninvasive FFR in coronary artery disease diagnosis. [ABSTRACT FROM AUTHOR]

Published
2020
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163. Causes and prognosis of symptomatic pericardial effusions treated by pericardiocentesis in an Asian academic medical centre.

Author

Xian Pei Cheong, Ka Peng Law, Lawrence, Swee-Chong Seow, Lik Wui Edgar Tay, Huay Cheem Tan, Wee Tiong Yeo, Low, Adrian F., and Kojodjojo, Pipin

Abstract

INTRODUCTION This study aimed to investigate the causes, clinical management and outcomes of clinically significant pericardial effusions, and evaluate the practice of pericardiocentesis within an academic medical centre in Singapore, a multiethnic country in Southeast Asia. METHODS Consecutive patients undergoing pericardiocentesis at a single Asian academic medical centre were identified. Patient demographics, echocardiographic findings, investigations, pericardiocentesis procedural details and clinical progress were tracked using a comprehensive electronic medical records system. RESULTS Of 149 patients who underwent pericardiocentesis, malignancy (46.3%) was the most common cause of pericardial effusions, followed by iatrogenic postsurgical complications (17.4%). 77.3% of effusions were large and 69.8% demonstrated tamponade physiology. Pericardiocentesis guided by echocardiography and fluoroscopy was successful in 99.3% of patients and had a complication rate of 2.0%. Likelihood of effusion recurrence and survival to discharge was determined by the aetiology of the pericardial effusion. 24.6% of malignant effusions recurred, and the survival rate 12 months after drainage of a malignant pericardial effusion was 45.0%. Short-term mortality was highest among patients presenting with tamponade due to acute aortic syndromes and those with myocardial rupture due to ischaemic heart disease. CONCLUSION Cancer and iatrogenic complications were the most common causes of pericardial effusion in this large cohort of Singapore patients. Pericardiocentesis has a high success rate and relatively low complication rate. Prognosis and clinical course after pericardiocentesis are determined by the underlying cause of the pericardial effusion. [ABSTRACT FROM AUTHOR]

Published
2020
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166. Incidence and predictors of target lesion failure in a multiethnic Asian population receiving the SYNERGY coronary stent: A prospective all-comers registry

Author

Ananthakrishna, Rajiv, primary, Kristanto, William, additional, Liu, Li, additional, Chan, Siew-Pang, additional, Loh, Poay Huan, additional, Tay, Edgar L., additional, Chan, Koo Hui, additional, Chan, Mark Y., additional, Lee, Chi-Hang, additional, Low, Adrian F., additional, Tan, Huay Cheem, additional, and Loh, Joshua P., additional

Published
2018
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170. Prognostic Implications of Dual Platelet Reactivity Testing in Acute Coronary Syndrome

Author

de Carvalho, Leonardo, additional, Fong, Alan, additional, Troughton, Richard, additional, Yan, Bryan, additional, Chin, Chee-Tang, additional, Poh, Sock-Cheng, additional, Mejin, Melissa, additional, Huang, Nancy, additional, Seneviratna, Aruni, additional, Lee, Chi-Hang, additional, Low, Adrian, additional, Tan, Huay-Cheem, additional, Chan, Siew-Pang, additional, Frampton, Christopher, additional, Richards, A., additional, and Chan, Mark, additional

Published
2018
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174. Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia

Author

Han, Yi, primary, Dorajoo, Rajkumar, additional, Chang, Xuling, additional, Wang, Ling, additional, Khor, Chiea-Chuen, additional, Sim, Xueling, additional, Cheng, Ching-Yu, additional, Shi, Yuan, additional, Tham, Yih Chung, additional, Zhao, Wanting, additional, Chee, Miao Ling, additional, Sabanayagam, Charumathi, additional, Chee, Miao Li, additional, Tan, Nicholas, additional, Wong, Tien Yin, additional, Tai, E-Shyong, additional, Liu, Jianjun, additional, Goh, Daniel Y. T., additional, Yuan, Jian-Min, additional, Koh, Woon-Puay, additional, van Dam, Rob M., additional, Low, Adrian F., additional, Chan, Mark Yan-Yee, additional, Friedlander, Yechiel, additional, and Heng, Chew-Kiat, additional

Published
2017
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175. Thymosin Beta‐4 Is Elevated in Women With Heart Failure With Preserved Ejection Fraction

Author

Drum, Chester L., primary, Tan, Warren K. Y., additional, Chan, Siew‐Pang, additional, Pakkiri, Leroy S., additional, Chong, Jenny P. C., additional, Liew, Oi‐Wah, additional, Ng, Tze‐Pin, additional, Ling, Lieng‐Hsi, additional, Sim, David, additional, Leong, Kui‐Toh G., additional, Yeo, Daniel P. S., additional, Ong, Hean‐Yee, additional, Jaufeerally, Fazlur, additional, Wong, Raymond C. C., additional, Chai, Ping, additional, Low, Adrian F., additional, Davidsson, Pia, additional, Liljeblad, Mathias, additional, Söderling, Ann‐Sofi, additional, Gan, Li‐Ming, additional, Bhat, Ratan V., additional, Purnamawati, Kristy, additional, Lam, Carolyn S. P., additional, and Richards, A. Mark, additional

Published
2017
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176. VAT And Non-Profit Organisations In The UAE

Author

Low, Adrian

Subjects
Taxation -- Economic aspects -- Forecasts and trends -- Laws, regulations and rules, Charities -- Laws, regulations and rules, Tax law -- Analysis, Value-added tax -- Economic aspects -- Forecasts and trends, Government regulation, Tax law, Market trend/market analysis, Business, international
Abstract

With the implementation of Value Added Tax (VAT) in the UAE from 1 January 2018, the deadline is looming and many charities and non-profit organisations are confused as to their [...]

Published
2017

177. UAE VAT: Two Urgent Action Points For Businesses

Author

Low, Adrian

Subjects
Tax law -- Interpretation and construction, Value-added tax -- Laws, regulations and rules -- Economic aspects, Government regulation, Tax law, Business, international
Abstract

The draft UAE Executive Regulations provide two immediate action points - register for VAT as soon as possible and review your contractual position. In this article we explain why these [...]

Published
2017

183. INCIDENCE AND PREDICTORS OF TARGET LESION FAILURE IN A MULTI-ETHNIC ASIAN POPULATION RECEIVING THE SYNERGY CORONARY STENT: A PROSPECTIVE ALL-COMERS REGISTRY

Author

Loh, Joshua Ping Yun, primary, Ananthakrishna, Rajiv, additional, Kristanto, William, additional, Li, Liu, additional, Chan, Siew Pang, additional, Loh, Poay Huan, additional, Tay, Edgar, additional, Chan, Mark, additional, Chan, Koo, additional, Lee, Ronald C.H., additional, Low, Adrian, additional, and Tan, Huay-Cheem, additional

Published
2017
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185. Reply

Author

Bulluck, Heerajnarain, primary, Foin, Nicolas, additional, Cabrera-Fuentes, Hector A., additional, Yeo, Khung K., additional, Wong, Aaron S., additional, Fam, Jiang M., additional, Wong, Philip E., additional, Tan, Jack W., additional, Low, Adrian F., additional, and Hausenloy, Derek J., additional

Published
2017
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186. Gender Differences in Native Myocardial T1 in a Healthy Chinese Volunteer Cohort

Author

Bulluck, Heerajnarain, primary, Bryant, Jennifer A, additional, Tan, Jonan Zhien, additional, Go, Yun Yun, additional, Le, Thu-Thao, additional, Tan, Ru San, additional, Lim, Tiong Keng, additional, Tang, Hak Chiaw, additional, Lath, Narayan, additional, Low, Adrian Shoen, additional, Chin, Calvin Woon-Loong, additional, Cook, Stuart A, additional, and Hausenloy, Derek J, additional

Published
2017
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187. Abstract 11521: Circulating Thymosin Beta-4 is Elevated in Women With Heart Failure

Author

Tan, Warren K, primary, Chan, Siew Pang, additional, Pakkiri, Leroy S, additional, Chong, Jenny P, additional, Chen, Zhaojin, additional, Liew, Oi Wah, additional, Ng, Tze Pin, additional, Ling, Lieng Hsi, additional, Sim, David K, additional, Leong, Gerard K, additional, Yeo, Daniel P, additional, Ong, Hean-Yee, additional, Jaufeerally, Fazlur R, additional, Wong, Raymond C, additional, Chai, Ping, additional, Low, Adrian F, additional, Davidsson, Pia, additional, Gan, Li-Ming, additional, Ratan, Bhat, additional, Purnamawati, Kristy, additional, Lam, Carolyn S, additional, Richards, Arthur M, additional, and Drum, Chester L, additional

Published
2016
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189. TCT-404 ABSORB bioresorbable vascular scaffold vs. everolimus-eluting metallic stent in ST-segment elevation myocardial infarction (BVS EXAMINATION study): 2-year results from a propensity score matched comparison

Author

brugaletta, salvatore, primary, Gori, Tommaso, additional, Low, Adrian, additional, Tousek, Petr, additional, Bermudez, Eduardo Pinar, additional, Lara, Josep Gomez, additional, Ortega-Paz, Luis, additional, Schulz, Eberhard, additional, Chan, Mark, additional, Kocka, Viktor, additional, Hurtado, Jose, additional, Gomez-Hospital, Joan Antoni, additional, Muenzel, Thomas, additional, Lee, Chi-Hang, additional, Cequier, Angel, additional, Valdes, Mariano, additional, Widimsky, Petr, additional, Serruys, Patrick, additional, and Sabate, Manel, additional

Published
2016
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191. New UAE Bankruptcy Law - How Are Creditors Protected?

Author

Low, Adrian

Subjects
Commercial law -- Interpretation and construction, Legal liability -- Evaluation, Bankruptcy law -- Interpretation and construction, Business, international
Abstract

In our previous two briefings on the Bankruptcy Law, we have looked at a summary of the key changes made by the Law, and the potential personal liability faced by [...]

Published
2016

192. Companies In Financial Difficulties: What Do Directors Need To Know About The UAE Bankruptcy Law?

Author

Low, Adrian

Subjects
Bankruptcy -- Laws, regulations and rules, Business enterprises -- Laws, regulations and rules, Bankruptcy law -- Interpretation and construction, Government regulation, Company bankruptcy, Business, international
Abstract

The new UAE Bankruptcy Law (Federal Law No. 9 of 2016) has put a spotlight on the treatment of companies in financial difficulties in the United Arab Emirates. It comes [...]

Published
2016

194. Bioresorbable vascular scaffold radial expansion and conformation compared to a metallic platform: insights from in vitro expansion in a coronary artery lesion model

Author

Foin, Nicolas, primary, Lee, Renick, additional, Bourantas, Christos, additional, Mattesini, Alessio, additional, Soh, Nicole, additional, Lim, Jie En, additional, Torii, Ryo, additional, Ng, Jaryl, additional, Liang, Leo Hwa, additional, Caiazzo, Gianluca, additional, Fabris, Enrico, additional, Kilic, Dogu, additional, Onuma, Yoshinobu, additional, Low, Adrian F., additional, Nijjer, Sukh, additional, Sen, Sayan, additional, Petraco, Ricardo, additional, Al Lamee, Rasha, additional, Davies, Justin E., additional, Di Mario, Carlo, additional, Wong, Philip, additional, and Serruys, Patrick W., additional

Published
2016
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195. ABSORB bioresorbable vascular scaffold vs. everolimus-eluting metallic stent in ST-segment elevation myocardial infarction (BVS EXAMINATION study): 2-Year results from a propensity score matched comparison

Author

Brugaletta, Salvatore, primary, Gori, Tommaso, additional, Low, Adrian F., additional, Tousek, Petr, additional, Pinar, Eduardo, additional, Gomez-Lara, Josep, additional, Ortega-Paz, Luis, additional, Schulz, Eberhard, additional, Chan, Mark Y., additional, Kocka, Viktor, additional, Hurtado, Jose, additional, Gomez-Hospital, Joan Antoni, additional, Giacchi, Giuseppe, additional, Münzel, Thomas, additional, Lee, Chi-Hang, additional, Cequier, Angel, additional, Valdés, Mariano, additional, Widimsky, Petr, additional, Serruys, Patrick W., additional, and Sabaté, Manel, additional

Published
2016
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197. DUAL PLATELET REACTIVITY TESTING IN ACUTE CORONARY SYNDROME

Author

Chan, Mark Y.Y., primary, Carvalho, Leonardo, additional, Fong, Alan, additional, Chin, Chee Tang, additional, Poh, Sock Cheng, additional, Frampton, Christopher, additional, Lee, Chi-Hang, additional, Low, Adrian, additional, Tan, Huay-Cheem, additional, Troughton, Richard, additional, Yan, Bryan P., additional, Chan, Siew-Pang, additional, and Richards, Mark, additional

Published
2016
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200. How temporal evolution of intracranial collaterals in acute stroke affects clinical outcomes

Author

Yeo, Leonard L.L., primary, Paliwal, Prakash, additional, Low, Adrian F., additional, Tay, Edgar L.W., additional, Gopinathan, Anil, additional, Nadarajah, Mahendran, additional, Ting, Eric, additional, Venketasubramanian, Narayanaswamy, additional, Seet, Raymond C.S., additional, Ahmad, Aftab, additional, Chan, Bernard P.L., additional, Teoh, Hock L., additional, Soon, Derek, additional, Rathakrishnan, Rahul, additional, and Sharma, Vijay K., additional

Published
2016
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