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563 results on '"Maejima, Yasuhiro"'

151. Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects the Heart Against Energy Stress

Author

Ikeda, Yoshiyuki, primary, Shirakabe, Akihiro, additional, Maejima, Yasuhiro, additional, Zhai, Peiyong, additional, Sciarretta, Sebastiano, additional, Toli, Jessica, additional, Nomura, Masatoshi, additional, Mihara, Katsuyoshi, additional, Egashira, Kensuke, additional, Ohishi, Mitsuru, additional, Abdellatif, Maha, additional, and Sadoshima, Junichi, additional

Published
2015
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160. Low Dose Carperitide (alpha-hANP) Administration is Effective for Preventing Worsening Renal Function (WRF) and Long-term Renal Protection

Author

Sasaoka, Taro, primary, Seya, Mie, additional, Hatano, Yu, additional, Tao, Susumu, additional, Sasaki, Takeshi, additional, Yoshikawa, Shunji, additional, Maejima, Yasuhiro, additional, Kawabata, Mihoko, additional, Goya, Masahiko, additional, Ashikaga, Takashi, additional, Hirao, Kenzo, additional, and Isobe, Mitsuaki, additional

Published
2014
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168. Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure.

Author

Akihiro Shirakabe, Peiyong Zhai, Yoshiyuki Ikeda, Toshiro Saito, Yasuhiro Maejima, Chiao-Po Hsu, Masatoshi Nomura, Kensuke Egashira, Beth Levine, Junichi Sadoshima, Shirakabe, Akihiro, Zhai, Peiyong, Ikeda, Yoshiyuki, Saito, Toshiro, Maejima, Yasuhiro, Hsu, Chiao-Po, Nomura, Masatoshi, Egashira, Kensuke, Levine, Beth, and Sadoshima, Junichi

Published
2016
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199. Brief Report: Takayasu Arteritis and Ulcerative Colitis: High Rate of Co-Occurrence and Genetic Overlap.

Author

Terao, Chikashi, Matsumura, Takayoshi, Yoshifuji, Hajime, Kirino, Yohei, Maejima, Yasuhiro, Nakaoka, Yoshikazu, Takahashi, Meiko, Amiya, Eisuke, Tamura, Natsuko, Nakajima, Toshiki, Origuchi, Tomoki, Horita, Tetsuya, Matsukura, Mitsuru, Kochi, Yuta, Ogimoto, Akiyoshi, Yamamoto, Motohisa, Takahashi, Hiroki, Nakayamada, Shingo, Saito, Kazuyoshi, and Wada, Yoko

Subjects
ACADEMIC medical centers, CONFIDENCE intervals, STATISTICAL correlation, REPORTING of diseases, FISHER exact test, GENETIC polymorphisms, RESEARCH funding, T-test (Statistics), ULCERATIVE colitis, COMORBIDITY, GENOMICS, DATA analysis software, TAKAYASU arteritis, ODDS ratio, GENOTYPES
Abstract

Objective Takayasu arteritis (TAK) is a systemic vasculitis affecting large arteries and large branches of the aorta. Ulcerative colitis (UC) is a prevalent autoimmune colitis. Since TAK and UC share HLA-B*52:01 and IL12B as genetic determinants, and since there are case reports of the co-occurrence of these diseases, we hypothesized that UC is a common complication of TAK. We undertook this study to perform a large-scale analysis of TAK, both to evaluate the prevalence of concurrent cases of TAK and UC and to identify and estimate susceptibility genes shared between the 2 diseases. Methods We analyzed a total of 470 consecutive patients with TAK from 14 institutions. We characterized patients with TAK and UC by analyzing clinical manifestations and genetic components. Genetic overlapping of TAK and UC was evaluated with the use of UC susceptibility single-nucleotide polymorphisms by comparing risk directions and effect sizes between susceptibility to the 2 diseases. Results Thirty of 470 patients with TAK had UC (6.4% [95% confidence interval 4.3-9.0]). This percentage was strikingly higher than that expected from the prevalence of UC in Japan. Patients with TAK complicated with UC developed TAK at an earlier stage of life ( P = 0.0070) and showed significant enrichment of HLA-B*52:01 compared to TAK patients without UC ( P = 1.0 × 10−5) (odds ratio 12.14 [95% confidence interval 2.96-107.23]). The 110 non-HLA markers of susceptibility to UC significantly displayed common risk directions with susceptibility to TAK ( P = 0.0054) and showed significant departure of permutation P values from expected P values ( P < 1.0 × 10−10). Conclusion UC is a major complication of TAK. These 2 diseases share a significant proportion of their genetic background, and HLA-B*52:01 may play a central role in their co-occurrence. [ABSTRACT FROM AUTHOR]

Published
2015
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200. Clinical Characteristics of Definite or Suspected Isolated Cardiac Sarcoidosis: Application of Cardiac Magnetic Resonance Imaging and 18F-Fluoro-2-deoxyglucose Positron-Emission Tomography/Computerized Tomography.

Author

Tezuka, Daisuke, Terashima, Masahiro, Kato, Yoko, Toriihara, Akira, Hirasawa, Kensuke, Sasaoka, Taro, Yoshikawa, Shunji, Maejima, Yasuhiro, Ashikaga, Takashi, Suzuki, Jun-ichi, Hirao, Kenzo, and Isobe, Mitsuaki

Abstract

Background Isolated cardiac sarcoidosis (iCS) is difficult to diagnose in patients without histologic evidence of sarcoidosis. We aimed to clarify the clinical characteristics of iCS, including imaging features on cardiac magnetic resonance imaging (MRI) and 18 F-fluoro-2-deoxyglucose positron-emission tomography/computerized tomography (FDG-PET/CT) scans. We also reviewed the therapeutic effect of corticosteroids and determined the long-term prognosis. Methods and Results We retrospectively reviewed 83 consecutive patients with suspicious CS from 1997 to 2013. Systemic sarcoidosis with CS (sCS, n = 30) and iCS (n = 11) were diagnosed according to clinical criteria. In iCS cases, sarcoidosis was not detected in any other organs. The clinical features did not significantly differ between sCS and iCS cases, except for ejection fraction, which was lower in iCS ( P = .025). Nine sCS and 4 iCS cases showed late gadolinium enhancement, and the lesions tended to be on the epicardial side (76.9% P = .011) and septal wall (52.9% P < .001). The coefficient of variance for the myocardial standardized uptake value of FDG-PET/CT was higher in sCS (0.32 ± 0.13; n = 19) and iCS (0.32 ± 0.09; n = 7) than in control cases (n = 31; P < .001). B-Type natriuretic peptide level was improved after prednisolone treatment in both groups. Kaplan-Meier curve indicated that prognosis was not different between sCS and iCS cases. Conclusions The clinical cardiac characteristics of iCS cases were similar to those of sCS. Cardiac MRI and FDG-PET, noninvasive imaging modalities, could be useful modalities to detect myocardial involvement in the cases with definite or suspected iCS. [ABSTRACT FROM AUTHOR]

Published
2015
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