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33,874 results on '"Mahdavi, A."'

152. Interaction of noncoding RNAs with hippo signaling pathway in cancer cells and cancer stem cells

Author

Saba Abedimanesh, Reza Safaralizadeh, Zohreh Jahanafrooz, Souzan Najafi, Mohammad Amini, Shabnam Soltani Nazarloo, Seyedeh Zahra Bahojb Mahdavi, Behzad Baradaran, Asiyeh Jebelli, and Amir Ali Mokhtarzadeh

Subjects
Non-coding RNA, Hippo pathway, Cancer cell, Cancer stem cell, Genetics, QH426-470
Abstract

The Hippo signaling pathway has a regulatory function in the organogenesis process and cellular homeostasis, switching the cascade reactions of crucial kinases acts to turn off/on the Hippo pathway, altering the downstream gene expression and thereby regulating proliferation, apoptosis, or stemness. Disruption of this pathway can lead to the occurrence of various disorders and different types of cancer. Recent findings highlight the importance of ncRNAs, such as microRNA, circular RNA, and lncRNAs, in modulating the Hippo pathway. Defects in ncRNAs can disrupt Hippo pathway balance, increasing tumor cells, tumorigenesis, and chemotherapeutic resistance. This review summarizes ncRNAs' inhibitory or stimulatory role in - Hippo pathway regulation in cancer and stem cells. Identifying the relation between ncRNAs and the components of this pathway could pave the way for developing new biomarkers in the treatment and diagnosis of cancers.

Published
2024
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153. Disturbance of the human gut microbiota in patients with Myotonic Dystrophy type 1

Author

Manijeh Mahdavi, Karine Prévost, Philippe Balthazar, Isabelle Fisette-Paul Hus, Élise Duchesne, Nicolas Dumont, Valérie Gagné-Ouellet, Cynthia Gagnon, Isabelle Laforest-Lapointe, and Eric Massé

Subjects
Myotonic Dystrophy type 1, DM1, Microbiome, Gut microbiota, Gastrointestinal symptoms, Bacterial communities, Biotechnology, TP248.13-248.65
Abstract

Myotonic dystrophy type 1 (DM1) is a rare autosomal dominant genetic disorder. Although DM1 is primarily characterized by progressive muscular weakness, it exhibits many multisystemic manifestations, such as cognitive deficits, cardiac conduction abnormalities, and cataracts, as well as endocrine and reproductive issues. Additionally, the gastrointestinal (GI) tract is frequently affected, encompassing the entire digestive tract. However, the underlying causes of these GI symptoms remain uncertain, whether it is biomechanical problems of the intestine, involvement of bacterial communities, or both. The primary objective of this study is to investigate the structural changes in the gut microbiome of DM1 patients. To achieve this purpose, 35 patients with DM1 were recruited from the DM-Scope registry of the neuromuscular clinic in the Saguenay–Lac-St-Jean region of the province of Québec, Canada. Stool samples from these 35 patients, including 15 paired samples with family members living with them as controls, were collected. Subsequently, these samples were sequenced by 16S MiSeq and were analyzed with DADA2 to generate taxonomic signatures. Our analysis revealed that the DM1 status correlated with changes in gut bacterial community. Notably, there were differences in the relative abundance of Bacteroidota, Euryarchaeota, Fusobacteriota, and Cyanobacteria Phyla compared to healthy controls. However, no significant shift in gut microbiome community structure was observed between DM1 phenotypes. These findings provide valuable insights into how the gut bacterial community, in conjunction with biomechanical factors, could potentially influence the gastrointestinal tract of DM1 patients.

Published
2024
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154. Investigation of Prevalence of cardiovascular involvement in patients with Covid-19 disease admitted to Afzalipour Hospital in Kerman in 2019-2020

Author

maryam maryam aliramezani, Amin Mahdavi, mahshid ghanbarnejad, mohammadjavad zarrabi, Sarehossadat Ebrahimi, and Maedeh Jafari

Subjects
hospitalizaed, prevalence, cardiovascular, covid-19, Immunologic diseases. Allergy, RC581-607, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background : Covid-19 can acute cardiovascular syndrome. The aim of this study was to determine the frequency of cardiovascular involvement in patients with Covid-19 disease .Methods:All patients who were diagnosed with Covid-19 disease and were hospitalized and monitored due to disease conditions (stages 2 and 3) were eligible to enter the study. At the beginning of the patient's hospitalization, the patients' vital signs were recorded and the first 12-lead ECG was taken. Patients then underwent cardiac monitoring. Patients underwent echocardiography during hospitalization. Preliminary tests including biochemistry, blood cell count, CRP and ESR and troponin were also performed for patients.Results:More than half of these patients are men. There was a significant relationship between Sinus.tach and history of heart disease (p = 0.02). The relationship between atrial fibrillation and history of heart disease was significant (p = 0.02). Nonspecific variable was also significantly associated with a history of heart disease (p = 0.04). Studies showed that ejection fraction was normal in 87.7% of patients and severe in 5.5%. There was a significant relationship between diastolic dysfunction grade and the history of heart disease (p = 0.02).Conclusion:The average age of patients with Covid-9 is 63.55%, 20.2% of people with a history of heart disease,Due to the sensitivity of the subject, the presence of underlying diseases,can increase the risk of Covid-19 disease and also increase the mortality rate of this disease in these. Therefore, it is suggested that more attention, priority in vaccinating against this disease in people with underlying diseases.

Published
2024
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179. Design, synthesis, in vitro, and in silico anti-α-glucosidase assays of N-phenylacetamide-1,2,3-triazole-indole-2-carboxamide derivatives as new anti-diabetic agents

Author

Sayahi, Mohammad Hossein, Zareei, Samira, Halimi, Mohammad, Alikhani, Majid, Moazzam, Ali, Mohammadi-Khanaposhtani, Maryam, Mojtabavi, Somayeh, Faramarzi, Mohammad Ali, Rastegar, Hossein, Taslimi, Parham, Ibrahim, Essam H., Ghramh, Hamed A., Larijani, Bagher, and Mahdavi, Mohammad

Published
2024
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183. Electrical lymph node scanning (ELS) system for real-time intra-operative detection of involved axillary lymph nodes in adjuvant breast cancer patients

Author

Abbasvandi, Fereshteh, Mahdavi, Reihane, Bayat, Mahdis, Hajighasemi, Farzane, Jahanbakhshi, Fahimeh, Aghaei, Faeze, Sami, Nafiseh, Khoundabi, Batoul, Ataee, Hossein, Yousefpour, Narges, Hoseinpour, Parisa, Mousavi Kiasary, Seyed Mohamad Sadegh, Omrani Hashemi, Maryam, Shojaeian, Fatemeh, Akbari, Atieh, Bagherhosseini, Najmeh, Moradi, Afshin, Akbari, Mohammad Esmaeil, and Abdolahad, Mohammad

Published
2024
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197. Clinical application of next generation sequencing for Mendelian disease diagnosis in the Iranian population

Author

Abolhassani, Ayda, Fattahi, Zohreh, Beheshtian, Maryam, Fadaee, Mahsa, Vazehan, Raheleh, Ahangari, Fatemeh, Dehdahsi, Shima, Faraji Zonooz, Mehrshid, Parsimehr, Elham, Kalhor, Zahra, Peymani, Fatemeh, Mozaffarpour Nouri, Maryam, Babanejad, Mojgan, Noudehi, Khadijeh, Fatehi, Fatemeh, Zamanian Najafabadi, Shima, Afroozan, Fariba, Yazdan, Hilda, Bozorgmehr, Bita, Azarkeivan, Azita, Sadat Mahdavi, Shokouh, Nikuei, Pooneh, Fatehi, Farzad, Jamali, Payman, Ashrafi, Mahmoud Reza, Karimzadeh, Parvaneh, Habibi, Haleh, Kahrizi, Kimia, Nafissi, Shahriar, Kariminejad, Ariana, and Najmabadi, Hossein

Published
2024
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