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554 results on '"Mandal, Santi M."'

152. Cm-p5: an antifungal hydrophilic peptide derived from the coastal mollusk Cenchritis muricatus (Gastropoda: Littorinidae)

Author

López-Abarrategui, Carlos, primary, McBeth, Christine, additional, Mandal, Santi M., additional, Sun, Zhenyu J., additional, Heffron, Gregory, additional, Alba-Menéndez, Annia, additional, Migliolo, Ludovico, additional, Reyes-Acosta, Osvaldo, additional, García-Villarino, Mónica, additional, Nolasco, Diego O., additional, Falcão, Rosana, additional, Cherobim, Mariana D., additional, Dias, Simoni C., additional, Brandt, Wolfgang, additional, Wessjohann, Ludger, additional, Starnbach, Michael, additional, Franco, Octavio L., additional, and Otero-González, Anselmo J., additional

Published
2015
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155. LC-MALDI-TOF MS-Based Rapid Identification of Phenolic Acids

Author

Mandal, Santi M. and Dey, Satyahari

Subjects
Molecular Weight, Molecular Structure, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Hydroxybenzoates, Articles, Plants, Crystallization, Chromatography, High Pressure Liquid, Biotechnology
Abstract

This study is the first on combined HPLC and MALDI-TOF MS analysis of phenolic acids. The analyses were carried out for phenolic acid mixtures and showed a unique, individual co-crystalline pattern for each phenolic acid. HPLC could distinguish phenolic acids and MALDI-TOF MS provided comparable mass (m/z) profiles for the samples. This combined study proved to be rapid in the accurate identification and structural analysis of phenolic acids with different masses.

Published
2008

157. The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

Author

Chatterjee, Arpita, primary, Saha, Saikat, additional, Chakraborty, Anirban, additional, Silva-Fernandes, Anabela, additional, Mandal, Santi M., additional, Neves-Carvalho, Andreia, additional, Liu, Yongping, additional, Pandita, Raj K., additional, Hegde, Muralidhar L., additional, Hegde, Pavana M., additional, Boldogh, Istvan, additional, Ashizawa, Tetsuo, additional, Koeppen, Arnulf H., additional, Pandita, Tej K., additional, Maciel, Patricia, additional, Sarkar, Partha S., additional, and Hazra, Tapas K., additional

Published
2015
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161. Understanding the patterns of antibiotic susceptibility of bacteria causing urinary tract infection in West Bengal, India

Author

Saha, Sunayana, primary, Nayak, Sridhara, additional, Bhattacharyya, Indrani, additional, Saha, Suman, additional, Mandal, Amit K., additional, Chakraborty, Subhanil, additional, Bhattacharyya, Rabindranath, additional, Chakraborty, Ranadhir, additional, Franco, Octavio L., additional, Mandal, Santi M., additional, and Basak, Amit, additional

Published
2014
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175. PdII/AgI-Catalyzed Room-Temperature Reaction of γ-Hydroxy Lactams: Mechanism, Scope, and Antistaphylococcal Activity.

Author

Dutta, Manali, Mandal, Santi M., Pegu, Rupa, and Pratihar, Sanjay

Abstract

The present work reports a PdII/AgI-promoted amidoalkylation reaction involving various γ-hydroxy lactams and C/O/S nucleophiles at room temperature. The dual mode of activation of both the electrophile and nucleophile by in situ generated catalytically active cationic PdII species facilitates the reaction at room temperature. Among the synthesized isoindoline derivatives, three compounds are found to be active against vancomycin and methicillin-resistant S. aureus strain with appreciable MIC values. [ABSTRACT FROM AUTHOR]

Published
2017
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176. Spectroscopic characterization, antimicrobial activity, DFT computation and docking studies of sulfonamide Schiff bases.

Author

Mondal, Sudipa, Mandal, Santi M., Mondal, Tapan Kumar, and Sinha, Chittaranjan

Subjects
*SULFONAMIDES, *SCHIFF bases, *ANTI-infective agents, *DENSITY functional theory, *SPECTRUM analysis
Abstract

Schiff bases synthesised from the condensation of 2-(hydroxy)naphthaldehyde and sulfonamides (sufathiazole (STZ), sulfapyridine (SPY), sulfadiazine (SDZ), sulfamerazine (SMZ) and sulfaguanidine (SGN)) are characterized by different spectroscopic data (FTIR, UV–Vis, Mass, NMR) and two of them, (E)-4-(((2-hydroxynaphthalen-1-yl)methylene)amino)- N -(thiazol-2-yl)benzenesulfonamide ( 1a ) and (E)- N -(diaminomethylene)-4-(((2-hydroxynaphthalen-1-yl)methylene)amino)benzenesulfonamide ( 1e ) have been confirmed by single crystal X-ray structure determination. Antimicrobial activities of the Schiff bases have been evaluated against certified and resistant Gram positive ( Staphylococcus aureus , Enterococcus facelis ) and Gram negative ( Streptococcus pyogenes , Salmonella typhi , Shigella dysenteriae, Shigella flexneri, Klebsiella pneumonia ) pathogens. Performance of Schiff base against the resistant pathogens are better than standard stain and MIC data lie 32–128 μg/ml while parent sulfonamides are effectively inactive (MIC >512 μg/ml). The DFT optimized structures of the Schiff bases have been used to accomplish molecular docking studies with DHPS (dihydropteroate synthase) protein structure (downloaded from Protein Data Bank) to establish the most preferred mode of interaction. ADMET filtration, Cytotoxicity (MTT assay) and haemolysis assay have been examined for evaluation of druglike character. [ABSTRACT FROM AUTHOR]

Published
2017
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177. Synergistic and Additive Effect of Oregano Essential Oil and Biological Silver Nanoparticles against Multidrug-Resistant Bacterial Strains.

Author

Scandorieiro, Sara, de Camargo, Larissa C., Lancheros, Cesar A. C., Yamada-Ogatta, Sueli F., Nakamura, Celso V., de Oliveira, Admilton G., Andrade, Célia G. T. J., Duran, Nelson, Nakazato, Gerson, Kobayashi, Renata K. T., Habiur, Rahman Md., Mandal, Santi M., and Habash, Marc

Subjects
MULTIDRUG resistance in bacteria, OREGANO, SILVER nanoparticles, PREVENTION
Abstract

Bacterial resistance to conventional antibiotics has become a clinical and public health problem, making therapeutic decisions more challenging. Plant compounds and nanodrugs have been proposed as potential antimicrobial alternatives. Studies have shown that oregano (Origanum vulgare) essential oil (OEO) and silver nanoparticles have potent antibacterial activity, also against multidrug-resistant strains; however, the strong organoleptic characteristics of OEO and the development of resistance to these metal nanoparticles can limit their use. This study evaluated the antibacterial effect of a two-drug combination of biologically synthesized silver nanoparticles (bio-AgNP), produced by Fusarium oxysporum, and OEO against Gram-positive and Gram-negative bacteria, including multidrug-resistant strains. OEO and bio-AgNP showed bactericidal effects against all 17 strains tested, with minimal inhibitory concentrations (MIC) ranging from 0.298 to 1.193 mg/mL and 62.5 to 250 µM, respectively. Time-kill curves indicated that OEO acted rapidly (within 10 min), while the metallic nanoparticles took 4 h to kill Gram-negative bacteria and 24 h to kill Gram-positive bacteria. The combination of the two compounds resulted in a synergistic or additive effect, reducing their MIC values and reducing the time of action compared to bio-AgNP used alone, i.e., 20 min for Gram-negative bacteria and 7 h for Gram-positive bacteria. Scanning electron microscopy (SEM) revealed similar morphological alterations in Staphylococcus aureus (non-methicillin-resistant S. aureus, non-MRSA) cells exposed to three different treatments (OEO, bio-AgNP and combination of the two), which appeared cell surface blebbing. Individual and combined treatments showed reduction in cell density and decrease in exopolysaccharide matrix compared to untreated bacterial cells. It indicated that this composition have an antimicrobial activity against S. aureus by disrupting cells. Both compounds showed very low hemolytic activity, especially at MIC levels. This study describes for the first time the synergistic and additive interaction between OEO and bio-AgNP produced by F. oxysporum against multidrug-resistant bacteria, such as MRSA, and β-lactamase- and carbapenemase-producing Escherichia coli and Acinetobacter baumannii strains. These results indicated that this combination can be an alternative in the control of infections with few or no treatment options. [ABSTRACT FROM AUTHOR]

Published
2016
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178. Antimicrobial Drugs in Fighting against Antimicrobial Resistance.

Author

Guyue Cheng, Menghong Dai, Ahmed, Saeed, Haihong Hao, Xu Wang, Zonghui Yuan, Mandal, Santi M., Xian-Zhi Li, and Nierman, William Charles

Subjects
ANTI-infective agents, PHARMACOKINETICS
Abstract

The outbreak of antimicrobial resistance, together with the lack of newly developed antimicrobial drugs, represents an alarming signal for both human and animal healthcare worldwide. Selection of rational dosage regimens for traditional antimicrobial drugs based on pharmacokinetic/pharmacodynamic principles as well as development of novel antimicrobials targeting new bacterial targets or resistance mechanisms are key approaches in tackling AMR. In addition to the cellular level resistance (i.e., mutation and horizontal gene transfer of resistance determinants), the community level resistance (i.e., bilofilms and persisters) is also an issue causing antimicrobial therapy difficulties. Therefore, anti-resistance and antibiofilm strategies have currently become research hotspot to combat antimicrobial resistance. Although metallic nanoparticles can both kill bacteria and inhibit biofilm formation, the toxicity is still a big challenge for their clinical applications. In conclusion, rational use of the existing antimicrobials and combinational use of new strategies fighting against antimicrobial resistance are powerful warranties to preserve potent antimicrobial drugs for both humans and animals. [ABSTRACT FROM AUTHOR]

Published
2016
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179. Synthesis of DNA-Intercalating 6 H-Benzo[ c]chromen-6-one Derivatives through a Strategic Combination of Garratt-Braverman and Minisci Acyloxylation Reactions.

Author

Bhattacharya, Prabuddha, Mandal, Santi M., and Basak, Amit

Subjects
*RING formation (Chemistry), *ESTERS, *CARBOXYLATES, *BROMIDES, *DNA analysis, *ETHIDIUM
Abstract

A new strategy for the synthesis of 6 H-benzo[ c]chromen-6-ones through judicious use of Garratt-Braverman (GB) Cyclization and Minisci acyloxylation reactions in moderate to good yield is reported. The uniqueness of the GB reaction is exemplified in providing the required biaryl esters, which could be successfully converted into the target skeleton by means of Minisci reaction on the free carboxylates. Ethidium bromide displacement and UV-based assay on the final molecules established them as DNA intercalators with binding constants in the range of about 104. [ABSTRACT FROM AUTHOR]

Published
2016
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183. Cn-AMP1: A new promiscuous peptide with potential for microbial infections treatment

Author

Silva, Osmar N., primary, Porto, William F., additional, Migliolo, Ludovico, additional, Mandal, Santi M., additional, Gomes, Diego G., additional, Holanda, Hortência H. S., additional, Silva, Rosa S. P., additional, Dias, Simoni C., additional, Costa, Maysa P., additional, Costa, Carolina R., additional, Silva, Maria R., additional, Rezende, Taia M. B., additional, and Franco, Octavio L., additional

Published
2012
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185. Role of Human DNA Glycosylase Nei-like 2 (NEIL2) and Single Strand Break Repair Protein Polynucleotide Kinase 3′-Phosphatase in Maintenance of Mitochondrial Genome

Author

Mandal, Santi M., primary, Hegde, Muralidhar L., additional, Chatterjee, Arpita, additional, Hegde, Pavana M., additional, Szczesny, Bartosz, additional, Banerjee, Dibyendu, additional, Boldogh, Istvan, additional, Gao, Rui, additional, Falkenberg, Maria, additional, Gustafsson, Claes M., additional, Sarkar, Partha S., additional, and Hazra, Tapas K., additional

Published
2012
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192. Inactivation of hnRNP K by Expanded Intronic AUUCU Repeat Induces Apoptosis Via Translocation of PKCδ to Mitochondria in Spinocerebellar Ataxia 10

Author

White, Misti C., primary, Gao, Rui, additional, Xu, Weidong, additional, Mandal, Santi M., additional, Lim, Jung G., additional, Hazra, Tapas K., additional, Wakamiya, Maki, additional, Edwards, Sharon F., additional, Raskin, Salmo, additional, Teive, Hélio A. G., additional, Zoghbi, Huda Y., additional, Sarkar, Partha S., additional, and Ashizawa, Tetsuo, additional

Published
2010
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