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PURPOSE: Predicting the survival of patients diagnosed with glioblastoma (GBM) is essential to guide surgical strategy and subsequent adjuvant therapies. Intraoperative ultrasound (IOUS) can contain biological information that could be correlated with overall survival (OS). We propose a simple extraction method and radiomic feature analysis based on IOUS imaging to estimate OS in GBM patients. METHODS: A retrospective study of surgically treated glioblastomas between March 2018 and November 2019 was performed. Patients with IOUS B-mode and strain elastography were included. After preprocessing, segmentation and extraction of radiomic features were performed with LIFEx software. An evaluation of semantic segmentation was carried out using the Dice similarity coefficient (DSC). Using univariate correlations, radiomic features associated with OS were selected. Subsequently, survival analysis was conducted using Cox univariate regression and Kaplan–Meier curves. RESULTS: Sixteen patients were available for analysis. The DSC revealed excellent agreement for the segmentation of the tumour region. Of the 52 radiomic features, two texture features from B-mode (conventional mean and the grey-level zone length matrix/short-zone low grey-level emphasis [GLZLM_SZLGE]) and one texture feature from strain elastography (grey-level zone length matrix/long-zone high grey-level emphasis [GLZLM_LZHGE]) were significantly associated with OS. After establishing a cut-off point of the statistically significant radiomic features, we allocated patients in high- and low-risk groups. Kaplan–Meier curves revealed significant differences in OS. CONCLUSION: IOUS-based quantitative texture analysis in glioblastomas is feasible. Radiomic tumour region characteristics in B-mode and elastography appear to be significantly associated with OS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40477-021-00569-9.

Background: Invasive fungal diseases represent an unmet clinical need that could benefit from novel immunotherapeutic approaches. Host pattern-recognition receptors (e.g., Toll-like receptors, C-type lectins or Scavenger receptors) that sense conserved fungal cell wall constituents may provide suitable immunotherapeutic antifungal agents. Thus, we explored the therapeutic potential of the lymphocyte class I scavenger receptor CD5, a non-redundant component of the antifungal host immune response that binds to fungal β-glucans.Methods: antifungal properties of the soluble ectodomain of human CD5 (shCD5) were assessed in vivo in experimental models of systemic fungal infection induced by pathogenic species (Candida albicans and Cryptococcus neoformans). In vitro mechanistic studies were performed by means of fungal-spleen cell co-cultures.Results: shCD5-induced survival of lethally infected mice was dose and time-dependent and concomitant with reduced fungal load and increased leukocyte infiltration in primary target organ. Additive effects were observed in vivo after shCD5 was combined with sub-optimal doses of fluconazole. Ex vivo addition of shCD5 to fungal-spleen cell co-cultures increased release of pro-inflammatory cytokines involved in antifungal defence (TNF-α and IFN-γ) and reduced the number of viable C. albicansConclusions: The results prompt further exploration of the adjunctive therapeutic potential of shCD5 in severe invasive fungal diseases. This work was supported by Spanish Ministerio de Economía y Competitividad (MINECO;SAF-2016-80535-R,PID2019-106658RB-I00 and PCIN-2015-070 to FL; SAF2017-86912-R to OZ) co-financed by European Development Regional Fund“A wa to achieve Europe” ERDF, and Agència de Gestió d’Ajuts Universitari side Recerca (AGAUR;2017/SGR/1582) from Generalitat de Catalunya. MV-dA,CC,SC- L,IS,JG- and EC are recipients of fellowships from Spanish MINECO (BES-2014-406069237; BES-2017-082107), Spanish Ministerio de Educación, Cultura y Deporte (FPU15/02897), Portuguese Fundação para a Ciênciae a Tecnologia (SFRH/BD/75738/2011), Uruguay an Agencia Nacional de Investigación e Innovación 409(POS-FCE-2018-1-1007796), and European Community Seventh Framework Program (BIOTRACK,FP7/2007/2013;229673), respectively Sí

CD5 and CD6 are closely related signal-transducing class I scavenger receptors mainly expressed on lymphocytes. Both receptors are involved in the modulation of the activation and differentiation cell processes triggered by clonotypic antigen-specific receptors present on T and B cells (TCR and BCR, respectively). To serve such a relevant immunomodulatory function, the extracellular region of CD5 and CD6 interacts with soluble and/or cell-bound endogenous counterreceptors but also microbial-associated molecular patterns (MAMPs). Evidence from genetically-modified mouse models indicates that the absence or blockade of CD5- and CD6-mediated signals results in dysregulated immune responses, which may be deleterious or advantageous in some pathological conditions, such as infection, cancer or autoimmunity. Bench to bedside translation from transgenic data is constrained by ethical concerns which can be overcome by exogenous administration of soluble proteins acting as decoy receptors and leading to transient “functional knockdown”. This review gathers information currently available on the therapeutic efficacy of soluble CD5 and CD6 receptor infusion in different experimental models of disease. The existing proof-of-concept warrants the interest of soluble CD5 and CD6 as safe and efficient immunotherapeutic agents in diverse and relevant pathological conditions.

We conducted a multicenter clinical validity study of the Panbio coronavirus disease 2019 Antigen Rapid Test of nasopharyngeal samples in pediatric patients with coronavirus disease 2019-compatible symptoms of ≤5 days of evolution. Our study showed limited accuracy in nasopharyngeal antigen testing: overall sensitivity was 45.4%, and 99.8% of specificity, positive-predictive value was 92.5%.

Background The consistency of meningioma is a factor that may influence surgical planning and the extent of resection. The aim of our study is to develop a predictive model of tumor consistency using the radiomic features of preoperative magnetic resonance imaging and the tumor elasticity measured by intraoperative ultrasound elastography (IOUS-E) as a reference parameter. Methods A retrospective analysis was performed on supratentorial meningiomas that were operated on between March 2018 and July 2020. Cases with IOUS-E studies were included. A semiquantitative analysis of elastograms was used to define the meningioma consistency. MRIs were preprocessed before extracting radiomic features. Predictive models were built using a combination of feature selection filters and machine learning algorithms: logistic regression, Naive Bayes, k-nearest neighbors, Random Forest, Support Vector Machine, and Neural Network. A stratified 5-fold cross-validation was performed. Then, models were evaluated using the area under the curve and classification accuracy. Results Eighteen patients were available for analysis. Meningiomas were classified as hard or soft according to a mean tissue elasticity threshold of 120. The best-ranked radiomic features were obtained from T1-weighted post-contrast, apparent diffusion coefficient map, and T2-weighted images. The combination of Information Gain and ReliefF filters with the Naive Bayes algorithm resulted in an area under the curve of 0.961 and classification accuracy of 94%. Conclusions We have developed a high-precision classification model that is capable of predicting consistency of meningiomas based on the radiomic features in preoperative magnetic resonance imaging (T2-weighted, T1-weighted post-contrast, and apparent diffusion coefficient map).

Background The effect of the production environment and different management practices in rabbit cecal microbiota remains poorly understood. While previous studies have proved the impact of the age or the feed composition, research in the breeding farm and other animal management aspects, such as the presence of antibiotics in the feed or the level of feeding, is still needed. Characterization of microbial diversity and composition of growing rabbits raised under different conditions could help better understand the role these practices play in cecal microbial communities and how it may result in different animal performance. Results Four hundred twenty-five meat rabbits raised in two different facilities, fed under two feeding regimes (ad libitum or restricted) with feed supplemented or free of antibiotics, were selected for this study. A 16S rRNA gene-based assessment through the MiSeq Illumina sequencing platform was performed on cecal samples collected from these individuals at slaughter. Different univariate and multivariate approaches were conducted to unravel the influence of the different factors on microbial alpha diversity and composition at phylum, genus and OTU taxonomic levels. The animals raised in the facility harboring the most stable environmental conditions had greater, and less variable, microbial richness and diversity. Bootstrap univariate analyses of variance and sparse partial least squares-discriminant analyses endorsed that farm conditions exerted an important influence on rabbit microbiota since the relative abundances of many taxa were found differentially represented between both facilities at all taxonomic levels characterized. Furthermore, only five OTUs were needed to achieve a perfect classification of samples according to the facility where animals were raised. The level of feeding and the presence of antibiotics did not modify the global alpha diversity but had an impact on some bacteria relative abundances, albeit in a small number of taxa compared with farm, which is consistent with the lower sample classification power according to these factors achieved using microbial information. Conclusions This study reveals that factors associated with the farm effect and other management factors, such as the presence of antibiotics in the diet or the feeding level, modify cecal microbial communities. It highlights the importance of offering a controlled breeding environment that reduces differences in microbial cecal composition that could be responsible for different animal performance.

Introduction Hospital-wide SARS-CoV-2 seroprevalence is rarely explored and can identify areas of unexpected risk. We determined the seroprevalence against SARS-CoV-2 in all health care workers (HCW) at a hospital. Methods Cross-sectional study (14-27/04/2020). We determined SARS-CoV-2 IgG by ELISA in all HCW including external workers of a teaching hospital in Madrid. They were classified by professional category, working area, and risk for SARS-CoV-2 exposure. Results Among 2919 HCW, 2590 (88,7%) were evaluated. The mean age was 43.8 years (SD 11.1), and 73.9% were females. Globally, 818 (31.6%) workers were IgG positive with no differences for age, sex or previous diseases. Of these, 48.5% did not report previous symptoms. Seropositivity was more frequent in high- (33.1%) and medium- (33.8%) than in low-risk areas (25.8%, p = 0.007), but not for hospitalization areas attending COVID-19 and non-COVID-19 patients (35.5 vs 38.3% p > 0.05). HWC with a previous SARS-CoV2 PCR-positive test were IgG seropositive in 90.8%. By multivariate logistic regression analysis seropositivity was significantly associated with being physicians (OR 2.37, CI95% 1.61–3.49), nurses (OR 1.67, CI95% 1.14–2.46), nurse assistants (OR 1.84, CI95% 1.24–2.73), HCW working at COVID-19 hospitalization areas (OR 1.71, CI95% 1.22–2.40), non-COVID-19 hospitalization areas (OR 1.88, CI95% 1.30–2.73), and at the Emergency Room (OR 1.51, CI95% 1.01–2.27). Conclusions Seroprevalence uncovered a high rate of infection previously unnoticed among HCW. Patients not suspected of having COVID-19 as well as asymptomatic HCW may be a relevant source for nosocomial SARS-CoV-2 transmission.

Background: the effect of the production environment and different management practices in rabbit cecal microbiota remains poorly understood. While previous studies have proved the impact of the age or the feed composition, research in the housing conditions and other animal management aspects, such as the presence of antibiotics in the feed or the level of feeding, is still needed. Characterization of microbial diversity and composition of growing rabbits raised under different conditions could help better understand the role these practices play in cecal microbial communities and how it may result in different animal performance.Results: four hundred twenty-five meat rabbits raised in two different facilities, fed under two feeding regimes (ad libitum or restricted) with feed supplemented or free of antibiotics, were selected for this study. A 16S rRNA gene-based assessment through the MiSeq Illumina sequencing platform was performed on cecal samples collected from these individuals at slaughter. Different univariate and multivariate approaches were conducted to unravel the influence of the different factors on microbial alpha diversity and composition at phylum, genus and OTU taxonomic levels. The animals raised in the facility harboring the most stable environmental conditions had greater, and less variable, microbial richness and diversity. Bootstrap univariate analyses of variance and sparse partial least squares-discriminant analyses endorsed that the farm exerted the largest influence on rabbit microbiota since the relative abundances of many taxa were found differentially represented between both facilities at all taxonomic levels characterized. Furthermore, only five OTUs were needed to achieve a perfect classification of samples according to the facility where animals were raised. The level of feeding and the presence of antibiotics did not modify the global alpha diversity but had an impact on some bacteria relative abundances, albeit in a small number of taxa compared with the farm, which is consistent with the lower sample classification power according to these factors achieved using microbial information.Conclusions: this study reveals different degrees of influence attributable to environment and animal management. It highlights the importance of offering a controlled breeding environment that reduces differences in microbial cecal composition that could be causative of different animal performance.

Echinococcus granulosus sensu lato (s.l.) is a cestode parasite affecting both human and livestock health. Recombinant ectodomains of human scavenger receptors CD5 (rshCD5) and CD6 (rshCD6) were previously reported to bind its tegumental antigens and to exert prophylactic effects in a murine model of infection. Although the properties of mammalian scavenger receptors include the binding to diverse pathogen-derived structures, their interaction with helminth parasites has been scarcely explored. Therefore, we report here a search for CD5 and CD6 interactors within E. granulosus s.l. antigens. Mass spectrometry analysis of pull-downs from soluble tegumental components with biotinylated rshCD5 and rshCD6 resulted in 17 and 11 overrepresented interactors, respectively, 8 of which were shared. The interactors included previously reported protective molecules against E. granulosus s.l. and/or other helminths. Similar studies performed with 11-mer peptides mapping to each of the three extracellular scavenger domains of CD5 and CD6 allowed an estimated molecular topology of the interactions. In conclusion, the fact that most helminth interactors identified for rshCD5 and rshCD6 were already reported as vaccine candidates or pharmacological targets against different helminthiases, supports the view that their beneficial effects in experimental infection results from binding to multiple relevant tegumental antigens.

Los relatos que componen este libro son evidencia de que fomentar espacios de integración, conocimiento y reconocimiento de las personas, más allá de su origen, sus experiencias o sus circunstancias económicas, es tal vez el mayor logro del programa de becas Icesos frente a una sociedad inequitativa. Esta apuesta social ha permitido que quienes, tenían oportunidades diferentes, confluyeran alrededor de intereses académicos, culturales y deportivos para forjar sus propios caminos y, además, construir país, contribuir con la región. La Universidad Icesi sigue trabajando para cumplir su misión de aprender a conocer y actuar para construir un mundo mejor. CONTENIDO: La constancia como medida del tiempo, Diego Fernández Rodríguez -- Intentar los sueños una y otra vez, Ferley Orozco Perdomo -- Cocodrilos para soñar Jhan Carlos Salazar Salazar -- La fuerza de la convicción y la familia, Diego Pineda Camero Fortaleza y creatividad, Edgar Eduardo Enciso Peña -- Las oportunidades como puertas al futuro, Diana Romero Quitián -- Marcar la diferencia, Lizeth Varela Díaz -- Un sueño de autonomía y dedicación, Carlos Alfonso Bonilla -- El amor y la vocación, Ana María Velasco Flórez -- Trabajar en beneficio de la comunidad, Angie Lizeth Calambás -- Estudiar para transformarse, Jhon Quinchua Ceballos -- Versatilidad para un buen futuro, Sergio Andrés Valencia Muñoz -- El compromiso social como apuesta de vida, Edwin Felipe Pito Romero -- La unión para lograr grandes cosas, Daniela Arango Samudio -- La pasión por el conocimiento, Luis Fernando García Neira -- Expandir los buenos cambios, Cristian Mera Murillo -- Dos historias inspiradoras en una misma familia, María Fernanda y Sandra Mosquera Charrupi -- Solidaridad para salir adelante, Tatiana Valencia Álvarez. Incluye tabla de contenido

BackgroundHealth-care workers (HCW) are at increased risk for SARS-CoV-2 infection, but few studies have evaluated prevalence of antibodies against SARS-CoV-2 among them.ObjectiveTo determine the seroprevalence against SARS-CoV-2 in all HCW.MethodsCross-sectional study (April 14th- 27th, 2020) of all HCW at Hospital Universitario Fundación Alcorcón, a second level teaching hospital in Madrid, Spain. SARS-CoV-2 IgG was measured by ELISA. HCW were classified by professional category, working area, and risk for SARS-CoV-2 exposure.ResultsAmong 2919 HCW, 2590 (90.5%) were evaluated. Mean age was 43.8 years (SD 11.1) and 73.9% were females. Globally, 818 (31.6%) workers were IgG positive, with no differences for age, sex or previous diseases. Among them, 48.5% did not report previous symptoms. Seropositivity was more frequent in high (33.1%) and medium (33.8%) than in low-risk areas (25.8%, p = 0.007), but no difference was found for hospitalization areas attending COVID-19 and non-COVID-19 patients (35.5 vs 38.3% p = NS). HCW with a previous SARS-CoV2 PCR positive test were IgG seropositive in 90.8%. By multivariate logistic regression analysis, seropositivity was associated with being physicians (OR 2.37, CI95% 1.61–3.49), nurses (OR 1.67, CI95% 1.14–2.46), or nurse- assistants (OR 1.84, CI95% 1.24–2.73), HCW working at COVID-19 hospitalization areas (OR 1.71, CI95% 1.22–2.40), non-COVID-19 hospitalization areas (OR 1.88, CI95% 1.30–2.73), and at the Emergency Room (OR 1.51, CI95% 1.01–2.27)ConclusionsSeroprevalence uncovered a high rate of infection previously unnoticed among HCW. Patients not suspected of having COVID-19 as well as asymptomatic HCW may be a relevant source for nosocomial SARS-CoV-2 transmission.

Little is known regarding the relevance of racial / ethnic background on the risk of COVID-IO infection, particularly in Europe. We evaluated the risk for COVID-19 among migrants from different areas of the world within a context of universal free access to medical care. We conducted a population-based cohort analysis of the cumulative incidence of PCR-confirmed COVID-19 among adult residents at Alcorcón (Spain) in the first wave of the disease. The crude cumulative incidence among migrants (n=20419) was higher than among Spaniards (n=131599): 8.81 and 6.51 and per 1000 inhabitants respectively (p

El Jurásico es uno de los períodos geológicos más emblemáticos y está generalmente asociado con los dinosaurios, sin embargo, la vegetación que dominó el paisaje a nivel mundial estuvo constituida por gimnospermas. En México el primer estudio sobre el registro fósil de plantas del Jurásico fue realizado a principios del siglo xx. Hoy en día se reconocen los afloramientos fosilíferos de la región Mixteca oaxaqueña como de los mejores de México por su abundancia y el buen estado de conservación de los fósiles. Con base en el estudio de éstos, se realizó una nueva propuesta paleoclimática y se actualizó la diversidad paleoflorística de la región. Hay dos localidades que sobresalen: Rosario Nuevo y Río Ñumí. La primera de ellas conserva troncos petrificados con longitudes de hasta ocho metros; mientras que la segunda presenta el listado paleoflorístico más diverso de toda la región. Todos los trabajos paleobotánicos de la Mixteca revisan el trabajo publicado por George Reber Wieland en 1914. Hoy, a más de un siglo de este estudio, podemos destacar y dar a conocer que el patrimonio paleobotánico de la Mixteca oaxaqueña es una fuente de información sobresaliente e irremplazable para la Paleontología mexicana.

Los hidrocarburos aromáticos tienen un alto potencial toxicológico, por lo que su evaluación en organismos acuáticos es de gran importancia. La microalga Chlorella vulgaris fue seleccionada, por ser una de las especies de algas más dominantes en el agua y por su potencial para degradar o absorber diferentes xenobióticos. El objetivo fue evaluar la toxicidad en C. vulgaris expuesta a fenantreno (PHE), evaluando parámetros fisiológicos como la densidad celular, contenido de clorofila a y clorofila b y actividad enzimática de superóxido dismutasa (SOD) y catalasa (CAT) que definan respuestas tóxicas a corto plazo. Se evaluaron cinco diferentes concentraciones (0,1; 1,0; 10; 100 y 1000 µg PHE. L-1), un tratamiento control solvente (acetona) y control (sin aditamentos) durante siete días. En todas las respuestas fisiológicas se observó un comportamiento dosis dependiente, disminuyendo progresivamente con el incremento de las concentraciones de PHE. La densidad celular, tasa de crecimiento, diámetro celular y clorofila pueden ser considerados biomarcadores de toxicidad. La actividad de CAT y SOD en C. vulgaris disminuyó considerablemente durante todo el periodo de estudio, posiblemente a causa de una excesiva producción de especies reactivas de oxígeno generadas por la exposición a fenantreno provocando la inhibición de estas enzimas antioxidantes. A pesar de la toxicidad de este hidrocarburo evidentemente observada en este estudio, C. vulgaris presenta una alta resistencia y adaptación a este contaminante, por lo que se puede decir que este microorganismo tiene la capacidad de evidenciar efectos toxicológicos en un entorno con este contaminante en un corto periodo de tiempo.

Prostate Fusion biopsy (MRI + prostate ultrasound) is described in literature as superior to classic random transrectal biopsy in order to identify suspicious lesion.To evaluate the Prostate Imaging Reporting and Data System (PI-RADS) proposed by the European Society of Urogenital Radiology (ESUR) for detection of prostate cancer by multiparametric MRI in a consecutive cohort of patients with MRI and transrectal ultrasound prostate fusion-guided biopsy.87 patients with suspected Prostatic Cancer on prostate MRI underwent fusion transperineal prostate biopsy in our Department. 37 patients had at least one prior negative classic prostatic transrectal biopsy. Clinically significant tumor was described as Gleason 7(3+4) or higher. The Chi-square test was used to analyze the relationship between prostate cancer and the different PIRADS stages, as well as logistic regression and linear trend tests, comparing the proportions using measures of association intensity. We use the HITACHI Real-Time Virtual Sonography (HI-RVS) system, and the STATA/IC v.14.2 software for statistical analysis.64.37% patients had tested positive for malignancy. Median age 67.89 years old. Median PSA 9.15 ng/ml, and average prostate volume was 54.05 cc. 124 suspicious lesions were described in prostate MRI (25% PIRADS III, 57% PIRADS IV and 17% PIRADS V). 5/31 lesions PIRADS III, 47/71 PIRADS IV and 18/22 PIRADS V were positive for malignancy, with a statistically significant linear relationship between PIRADS and malignancy (p0.001) - HR 4.10 (CI 95% 1.81 to 9.32) for PIRADS IV and HR 5.07 (CI95% 2.22 to 11.59) for PIRADS V vs. PIRADS III. 3.23% lesions PIRADS III, 32.39% PIRADS IV and 63.64% PIRADS V corresponded to significant tumors. A statistically significant association between PIRADS and significant tumors (p0.001) - HR 10.04 (CI95% 1.42 to 71.09) for PIRADS IV and HR 19.73 (CI95% 2.80 to 139.18) for PIRADS V vs PIRADS III was observed -.Our results show that transperineal targeted prostate biopsy using multiparametric MRI and transrectal ultrasound fusion is a safe procedure with excellent outcomes to obtain an accurate diagnosis of prostate cancer. Fusion biopsy has the potential to improve the diagnosis of malignancy and clinically significant tumors while reducing overdiagnosis.INTRODUCCIÓN: La biopsia prostática por fusión se describe como superior a la biopsia transrectal sistemática para identificar lesiones sospechosas de carcinoma de próstata.OBJETIVOS: Evaluar la clasificación PIRADS propuesto por la Sociedad Europea de Radiología Urogenital para la detección de cáncer de próstata mediante RNM en una cohorte consecutiva de pacientes con RNM y biopsia guiada por fusión.MATERIAL Y MÉTODOS: Estudio observacional transversal. 87 pacientes con sospecha de cáncer de próstata sometidos a biopsia de próstata transperineal y fusión con RNM en nuestro centro. Describimos tumor significativo como Gleason ≥7(3+4), y carcinoma de alto riesgo como Gleason ≥8. Utilizamos la prueba de Chi-cuadrado para analizar la relación entre cáncer de próstata y PIRADS, así como regresión logística y pruebas de tendencia lineal, comparando las proporciones con medidas de intensidad de asociación. Empleamos el sistema HITACHI Real-Time Virtual Sonography y el software STATA/IC v.14.2 para el análisis estadístico.RESULTADOS: 64,37% pacientes presentaron resultado positivo para malignidad. Media de edad 67,89 años (SD7,42), de PSA total 9,15 ng/ml (SD7,85), y de volumen prostático 54,05 cc (SD22,92). Se biopsiaron 124 lesiones sospechosas en RNM (25% PIRADS III, 57,26% PIRADS IV y 17,74% PIRADS V). 5/31 lesiones PIRADS III, 47/71 PIRADS IV y 18/22 PIRADS V fueron positivas para malignidad, con relación lineal estadísticamente significativa entre PIRADS y malignidad (p0,001), razón de prevalencias (RP) 4,10 (IC95% 1,81-9,32) para PIRADS IV, y RP 5,07 (CI95% 2,2211,59) para PIRADS V respecto a PIRADS III. 3,23% lesiones PIRADS III, 32,39% PIRADS IV y 63,64% PIRADS V correspondieron a tumores significativos. Encontramos asociación estadísticamente significativa entre PIRADS y tumores significativos (p0,001), RP 10,04 (IC95% 1,42-71,09) para PIRADS IV y RP 19,73 (IC95% 2,80139,18) para PIRADS V respecto a PIRADS III.CONCLUSIÓN: Nuestros resultados muestran que la biopsia de próstata ecodirigida y por fusión utilizando RNM es una técnica segura con excelentes resultados para obtener un diagnóstico preciso de cáncer de próstata, y puede mejorar el diagnóstico de malignidad y de tumores significativos reduciendo el sobrediagnóstico.

© Author(s) (or their employer(s)) 2020., [Background]: CD6 is a lymphocyte surface co-receptor physically associated with the T-cell receptor (TCR)/CD3 complex at the center of the immunological synapse. There, CD6 assists in cell-to-cell contact stabilization and modulation of activation/differentiation events through interaction with CD166/ALCAM (activated leukocyte cell adhesion molecule), its main reported ligand. While accumulating evidence is attracting new interest on targeting CD6 for therapeutic purposes in autoimmune disorders, little is known on its potential in cancer. In an attempt to elucidate the in vivo relevance of blocking CD6-mediated interactions in health and disease, we explored the consequences of expressing high circulating levels of a soluble form CD6 (sCD6) as a decoy receptor. [Methods]: High sCD6 serum levels were achieved by using transgenic C57BL/6 mice expressing human sCD6 under the control of lymphoid-specific transcriptional elements (shCD6LckEμTg) or wild type either transduced with hepatotropic adeno-associated virus coding for mouse sCD6 or undergoing repeated infusions of recombinant human sCD6 protein. Characterization of sCD6-induced changes was performed by ex vivo flow cytometry and functional analyses of mouse lymphoid organ cells. The in vivo relevance of those changes was explored by challenging mice with subcutaneous or metastatic tumors induced by syngeneic cancer cells of different lineage origins. [Results]: Through a combination of in vitro and in vivo studies, we show that circulating sCD6 expression induces defective regulatory T cell (Treg) generation and function, decreased CD166/ALCAM-mediated tumor cell proliferation/migration and impaired galectin-induced T-cell apoptosis, supporting the fact that sCD6 modulates antitumor lymphocyte effector function and tumorigenesis. Accordingly, sCD6 expression in vivo resulted in delayed subcutaneous tumor growth and/or reduced metastasis on challenge of mice with syngeneic cancer cells. [Conclusions]: Evidence is provided for the disruption of CD6 receptor-ligand interactions as a feasible immunomodulatory approach in cancer., This work was supported by the Worldwide Cancer Research (14-1275), Fundació La Marató TV3 (201319-30), and Ministerio de Economía y Competitividad (SAF-2016-80535-R) co-financed by European Development Regional Fund 'A way to achieve Europe' ERDF to FL; SAF2016-75195-R to JM, SAF2017-82905-R to RM, and SAF2015-70028-R to GG-A. ITS, MO-M, MV-dA, CC, SC-L and FA are recipients of fellowships from Fundação para a Ciência e a Tecnologia (SFRH/ BD/75738/2011), Ministerio de Economía y Competitividad (BES-2011-048415; BES-2014-069237; BES-2017-082107), Ministerio de Educación Cultura y Deporte (FPU15/02897), and Instituto de Salud Carlos III (Sara Borrell Programme, CD15/00016), respectively.

This chapter discusses the factors that have led to the emergence of expressions of criticism toward tourism. This review serves to frame the original contribution of this text: a theoretical model that clarifies the defining features of the main attitudes towards tourism. Merton's model is here adjusted for the analysis of a new relationship between social ends and economic means. In this case, the end is economic progress. The way is the tourism, conceived as a massive social phenomenon. The relation between goals and means generates tensions. Its management derives in strategies of adaptation that include different ways of identification or discussion. The five types of adaptation of the new model are useful for addressing subject positions, political discourses, or attitudinal dispositions towards tourism. To illustrate this typology a purposive sampling of news on the tourismphobia has been selected, with no statistical generalization reflecting the constituent elements of each of the types: legitimization, innovative criticism, resignation, radical criticism, and subversive utopia.

Background Chagas disease has spread beyond its original borders on the American continent with migration. It can be transmitted from mother to child, through organ transplantation and transfusion of blood and blood products. It is necessary to determine when to screen for this infection. Aim Our objective was to evaluate the appropriateness of screening for Trypanosoma cruzi infection in Latin American migrants and their descendants. Methods We reviewed the literature using rigorous criteria. The quality of evidence was ranked according to the GRADE classification. An evidence to decision framework was adopted to provide information on the most relevant aspects necessary to formulate recommendations. Results The 33 studies evaluated revealed a prevalence of T. cruzi infection among Latin American migrants in Europe of 6.08% (95% confidence interval (CI): 3.24–9.69; 28 studies). Vertical transmission occurred in three of 100 live births (95% CI: 1–6; 13 studies). The prevalence of cardiovascular disease was 19% (95% CI: 13–27; nine studies), including only 1% severe cardiac events (95% CI: 0–2; 11 studies). The overall quality of evidence was low because of risk of bias in the studies and considerable heterogeneity of the evaluated populations. The recommendations took into account economic studies on the value of screening strategies and studies on acceptability of screening and knowledge of the disease in the affected population. Conclusions We identified five situations in which screening for T. cruzi infection is indicated. We recommend screening persons from endemic areas and children of mothers from these areas.

We report the first human case of West Nile virus (WNV) lineage 2 infection imported to Spain by a traveler returning from Romania. Serum, cerebrospinal fluid and urine samples were analyzed and West Nile virus infection was identified by PCR and serological tests. The patient developed fever, diarrhea and neurological symptoms, accompanied by mild pancreatitis, described previously in very few cases as a complication of WNV infection and by alithiasic cholecystitis. Viral RNA was detected in urine until 30 days after the onset of symptoms and neutralizing antibodies were detected at very low titers. The phylogenetic analysis in a fragment of the NS5 gene of the virus showed a homology with sequences from WNV lineage 2 belonging to the monophyletic Central/Southern European group. This work was partially funded by the Instituto de Salud Carlos III Projects “PI14CIII/00014” and “PI19CIII_00014”. Sí

Feed efficiency (FE) is one of the most economically and environmentally relevant traits in the animal production sector. The objective of this study was to gain knowledge about the genetic control of FE in rabbits. To this end, GWASs were conducted for individual growth under two feeding regimes (full feeding and restricted) and FE traits collected from cage groups, using 114 604 autosome SNPs segregating in 438 rabbits. Two different models were implemented: (1) an animal model with a linear regression on each SNP allele for growth trait; and (2) a two‐trait animal model, jointly fitting the performance trait and each SNP allele content, for FE traits. This last modeling strategy is a new tool applied to GWAS and allows information to be considered from non‐genotyped individuals whose contribution is relevant in the group average traits. A total of 189 SNPs in 17 chromosomal regions were declared to be significantly associated with any of the five analyzed traits at a chromosome‐wide level. In 12 of these regions, 20 candidate genes were proposed to explain the variation of the analyzed traits, including genes such as FTO, NDUFAF6 and CEBPA previously associated with growth and FE traits in monogastric species. Candidate genes associated with behavioral patterns were also identified. Overall, our results can be considered as the foundation for future functional research to unravel the actual causal mutations regulating growth and FE in rabbits., This study was financed by Feed‐a‐Gene, which has received funding from the European Union’s H2020 program under grant agreement no. 63353 and the Spanish projects RTA2014‐00015‐C2‐01, RTA2011‐00064‐00‐00 and RTI2018‐097610‐R‐I00. M. Ballester is financially supported by a Ramon y Cajal contract (RYC‐2013‐12573) from the Spanish Ministry of Economy and Competitiveness.

The correlation between pedigree and genomic‐based inbreeding coefficients is usually discussed in the literature. However, some of these correlations could be spurious. Using partial correlations and information theory, it is possible to distinguish a significant association between two variables which is independent from associations with a third variable. The objective of this study is to implement partial correlations and information theory to assess the relationship between different inbreeding coefficients using a selected population of rabbits. Data from pedigree and genomic information from a 200K SNP chip were available. After applying filtering criteria, the data set comprised 437 animals genotyped for 114,604 autosomal SNP. Fifteen pedigree‐ and genome‐based inbreeding coefficients were estimated and used to build a network. Recent inbreeding coefficient based on runs of homozygosity had 9 edges linking it with different inbreeding coefficients. Partial correlations and information theory approach allowed to infer meaningful associations between inbreeding coefficients and highlighted the importance of the recent inbreeding based on runs of homozygosity, but a good proxy of it could be those pedigree‐based definitions reflecting recent inbreeding. info:eu-repo/semantics/acceptedVersion

Eight focus groups were conducted in four public hospitals in Madrid to explore healthcare professionals’ perceptions of advance directives (ADs) in order to improve the understanding of their lack of success among physicians and patients. A purposive sample of sixty healthcare professionals discussed ADs and reasons for their infrequent use. Three main themes were identified: perceptions about their meaning, appraisals of their use in clinical practice, and decision-making about them. Healthcare professionals perceived a lack of clarity about their definition and implementation. There is insufficient awareness of their efficacy in improving the quality of clinical relationships and decision-making, and they are often perceived only as a bureaucratic procedure. Advance directives are not integrated in the clinical practice of Madrid’s healthcare specialist services because their application is exceedingly complex, because of insufficient education about them (for both professionals and citizens), and because of lack of procedural clarity. Consequently, healthcare professionals are not aware of how ADs could improve clinical decision-making, of when and for whom their use is appropriate, and of who has responsibility for providing ADs-related information to patients. These circumstances contribute to patients’ lack of interest in completing these documents and to physicians’ sceptical views about their usefulness. Sin financiación 2.652 JCR (2020) Q1, 13/56 Ethics 1.075 SJR (2020) Q1, 50/256 Health Policy No data IDR 2020 UEM

Objective. To evaluate Guinea grass (Panicum maximum Jacq.) cv Mombasa not only dynamic growing and cumulative fodder but also determining its optimal period for harvesting. Material and methods. Under a five-repetition random design, we assessed eight treatments that consisted in successive cuttings every ten days during seasonal time. At the beginning of each season, we divided the land by quadrants (0.64 m2) so that we could perform a uniformity cutting size of 5 cm height at ground level. Assessments in plant height, cumulative forage, botanical and morphological composition, growth rate (GR), leaf area ratio; and rations in leaf:stem and leaf:no leaf were carried out. Additionally, we analyzed data by means of SAS with MIXED and GLM procedures. Results. Cumulative forage was advanced in summer and spring (p≤0.05). Both forage yielding and GR increased gradually until leaves’ growth stabilized; so subsequent increments in forage were due to an increased amount in stem and dead material, just when GR declined. Growth rate was greater in summer (127 kg DM ha-1 d-1) exceeded GR, spring, autumn and winter by 26, 44 and 75 %) Conclusions. Results have suggested that an optimal handling of cv. Mombasa and a maximum production of its forage in the state of Chiapas could be obtained if it is harvested every 40, 50, 40 and 30 days during spring, summer, autumn and winter, respectively., Objetivo. Evaluar la dinámica de crecimiento y acumulación de forraje del pasto guinea (P. maximum Jacq.) cv. Mombasa, y definir el momento óptimo de cosecha. Materiales y métodos. Se evaluaron ocho tratamientos, que consistieron en cortes de forraje cada 10 días, durante las cuatro estaciones del año, bajo un diseño completamente al azar con cinco repeticiones. Al inicio de cada estación se realizó corte de uniformidad a 5 cm de altura, y se utilizaron cuadrantes (0.64 m2), para cortar el forraje a ras de suelo. Se evaluó altura de planta, acumulación de forraje, tasa de crecimiento (TC), índice de área foliar, relaciones hoja:tallo y hoja:no hoja, composición botánica y morfológica. Los datos se analizaron mediante Mixed y GLM de SAS. Resultados. La acumulación de forraje fue mayor en verano y primavera (p≤0.05). La acumulación de forraje y la TC incrementaron progresivamente hasta que el crecimiento de las hojas se estabilizó. Los incrementos posteriores de forraje se debieron al aumento de tallos y material muerto cuando la TC declinó. En verano la TC (127 kg MS ha-1d-1) superó en 26, 44 y 75% las TC de primavera, otoño e invierno. Conclusiones. De acuerdo a los resultados (estudios realizados), se sugiere que, en esta región del Estado de Chiapas, el manejo óptimo del cv. Mombasa y su mayor producción de forraje, se obtiene al cosechar cada 40, 50, 40 y 30 días en primavera, verano, otoño e invierno, respectivamente.

The relationship between tourism and climate change is reciprocal. The effects of climate change on tourism are undeniable. However, tourism and climate change are complex and cross-cutting phenome...

Coastal lagoons count among the marine habitats with the highest biological productivity, playing an important ecological role. Together with wetlands in general and coral reefs, they are also amongst the habitats with the highest value derived from the services they provide. This work aims to assess the natural goods and services provided by the Mar Menor coastal lagoon in Murcia (Spain), as well as the environmental risks it is exposed to. This ecosystem, as many coastal lagoons throughout the world, supports a great variety of important services but the resulting pressures are also the reasons that have led to its deterioration, showing signs of impact, whether environmental, social and even economic. In 2011 the European Commission proposed a common strategy on biodiversity, in an attempt to avoid its decline, and claim it as one of the main bases for sustainable economic development. In this context, this work also looks at the socioeconomic value of this emblematic environment using the contingent valuation method (CVM). A questionnaire was developed and presented to inhabitants and visitors of the Mar Menor area, including a broad representation of professions and activities, to identify stakeholder perception of the environment and how they evaluate the importance of ecological processes for maintaining ecosystem functioning and the goods and services provided. The perception and valuation of goods and services provided by ecosystem functioning and biodiversity in the Mar Menor lagoon depended on the different groups considered (by age, professional activity, residence, educational background or sex), although in general, stakeholders, including fishermen, perceived that tourism services are the most important. Interestingly, the sectors related to construction and fishing were well aware of the risks derived from their own activities. The evaluation of services and the perception of the principal environmental risks and impacts were high for all the groups of users considered, and the indirect use and non-use value of the lagoon ecosystem conservation was established in 43,326,181 Euros/year.

Background In Spain, migrants are disproportionately affected by HIV and experience high rates of late diagnosis. We investigated barriers to health care access among migrants living with HIV (MLWH) in Spain. Methods Cross sectional electronic survey of 765 adult HIV-positive migrants recruited within 18 health care settings between July 2013 and July 2015. We collected epidemiological, demographic, behavioral and clinical data. We estimated the prevalence and risk factors of self-reported barriers to health care using multivariable logistic regression. Results Of those surveyed, 672 (88%) had information on health care access barriers: 23% were women, 63% from Latin America and Caribbean, 14% from Sub-Saharan Africa and 15% had an irregular immigration status. Men were more likely to report barriers than women (24% vs. 14%, P = 0.009). The main barriers were: lengthy waiting times for an appointment (9%) or in the clinic (7%) and lack of a health card (7%). Having an irregular immigration status was a risk factor for experiencing barriers for both men (OR: (4.0 [95%CI: 2.2-7.2]) and women (OR: 10.5 [95%CI: 3.1-34.8]). Men who experienced racial stigma (OR: 3.1 [95%CI: 1.9-5.1]) or food insecurity (OR: 2.1 [95%CI: 1.2-3.4]) were more likely to report barriers. Women who delayed treatment due to medication costs (6.3 [95%CI: 1.3-30.8]) or had a university degree (OR: 5.8 [95%CI: 1.3-25.1]) were more likely to report barriers. Conclusion Health care barriers were present in one in five5 MLWH, were more common in men and were associated to legal entitlement to access care, perceived stigma and financial constraints.

El dolor abdominal es una causa frecuente de consulta al servicio de urgencias y la población anciana no es ajena a esta situación. En este grupo de pacientes, la dificultad en el enfoque diagnóstico radica en sus características particulares, como múltiples enfermedades concomitantes, medicación múltiple, deterioro cognitivo y cuidadores con pobre información, situaciones que favorecen múltiples consultas que llevan a diagnósticos erróneos y tardíos. Una de las causas de dolor abdominal en los ancianos son las catástrofes vasculares, como la angina mesentérica, enfermedad poco frecuente y con gran mortalidad, dado que su diagnóstico y su tratamiento son tardíos por la presentación atípica en esta población. Se reporta el caso de una paciente con antecedentes de demencia vascular, que consultó por dolor abdominal crónico y a quien se le diagnosticó angina mesentérica crónica.

Neuropathic pain can arise from lesions to peripheral or central nerve fibres leading to spontaneous action potential generation and a lowering of the nociceptive threshold. Clinically, neuropathic pain can manifest in many chronic disease states such as cancer, diabetes or multiple sclerosis (MS). The bioactive lipid, lysophosphatidic acid (LPA), via activation of its receptors (LPARs), is thought to play a central role in both triggering and maintaining neuropathic pain. In particular, following an acute nerve injury, the excitatory neurotransmitters glutamate and substance P are released from primary afferent neurons leading to upregulated synthesis of lysophosphatidylcholine (LPC), the precursor for LPA production. LPC is converted to LPA by autotaxin (ATX), which can then activate macrophages/microglia and modulate neuronal functioning. A ubiquitous feature of animal models of neuropathic pain is demyelination of damaged nerves. It is thought that LPA contributes to demyelination through several different mechanisms. Firstly, high levels of LPA are produced following macrophage/microglial activation that triggers a self-sustaining feed-forward loop of de novo LPA synthesis. Secondly, macrophage/microglial activation contributes to inflammation-mediated demyelination of axons, thus initiating neuropathic pain. Therefore, targeting LPA production and/or the family of LPA-activated G protein-coupled receptors (GPCRs) may prove to be fruitful clinical approaches to treating demyelination and the accompanying neuropathic pain. This review discusses our current understanding of the role of LPA/LPAR signalling in the initiation of neuropathic pain and suggests potential targeted strategies for its treatment. This article is part of the Special Issue entitled 'Lipid Sensing G Protein-Coupled Receptors in the CNS'.

Aim External cephalic version (ECV) is an effective and safe technique for avoiding breech presentation at birth. However, it continues rejected by many women. The aim of this study is to develop a predictive model of success of external cephalic version, determine the safety of the technique and perinatal outcomes after successful version. Methods Data from 317 versions performed over a 6-year period were collected. Different clinical and ultrasound variables, complications, vaginal delivery after successful version and perinatal outcomes were analyzed. Results The overall success rate was 72% (229 of 317 versions). The variables most related to success were parity, placental location, amniotic fluid volume, fetal sex, fetal head palpation and descent of the presenting part. A model for calculating the probability of success was developed in which to input parity, placentation and amniotic fluid data. The model correctly classified 98.8% of successful technique and 74% of all women. Complications were very few and mostly mild. Of women who had success, 77% (163 of 212) had a vaginal birth. No differences between neonatal outcomes were found. Conclusion External cephalic version is a successful, safe technique with a high rate of subsequent vaginal delivery. A success prediction model based on some very easily obtained variables can personalize the probability of success.

In 1922 Becker found an exact solution for shock waves in gases using the Navier-Stokes-Fourier constitutive equations for a Prandtl number of value 3/4 with constant transport coefficients. His analysis has been extended to study some cases where an implicit solution can be found in an exact way. In this work we consider this problem for the so-called soft-spheres model in which the viscosity and thermal conductivity are proportional to a power of the temperature η,κ∝T^{σ}. In particular, we give implicit exact solutions for the Maxwell model (σ=1), hard spheres (σ=1/2), and when σ (the viscosity index) is a natural number.

Background: micro-elimination has been recently proposed as an efficient strategy to achieve global hepatitis C virus (HCV) elimination. The Spanish Health Ministry Strategic Plan for hepatitis C infection highlighted intervention in prisons as a priority action. However, there are important barriers associated with the specialized care provision to the penitentiary population. Aims: to assess the contribution of telemedicine for HCV elimination in a correctional facility in Spain. Methods: an open label program of HCV elimination via telemedicine was started on February 3rd, 2015 in a large penitentiary of 1,200 inmates, as an alternative to referring patients to specialists. An anonymous satisfaction survey was performed among a random sample of inmates and all participating doctors. Results: the prevalence of HCV viremia prior to program initiation was 12.4%. One hundred and thirty-one patients received DAA HCV treatment during the period 2015-2018; 42.74% had a HCV-HIV co-infection. Overall, 97% achieved a sustained virological response (SVR). A second regime of DAA successfully rescued non-responder patients and the HCV prevalence was zero at the end of the program. Satisfaction was high or very high according to 67% of inmates and all participating doctors. Conclusion: telemedicine is an effective tool for HCV elimination in penitentiary correctional facilities where referral to specialists is difficult. The extensive use of this technology should be recommended in this setting in order to facilitate equitable access to specialized care.

Background The epidemiology of hospitalizations for Opportunistic Infections (OI) in patients with rheumatoid arthritis (RA) is unknown despite an increase in RA treatments that confer risk of infection. Objectives To analyze the incidence, trend and factors associated with hospitalizations due to OI in patients with RA, in Spain, during the period between 1999 and 2015. Methods Population study based on the analysis of a national administrative database that includes a Minimum Basic Data Set (MBDS) of the income of patients with RA (ICD 9 714). Period: January 1, 1999 to December 31, 2015. The following entities were included as OI: tuberculosis (tbc), nontuberculous mycobacteria, cytomegalovirus (CMV), Epstein-Barr virus (EBV), Herpes zoster (HZ), Candidiasis, Toxoplasmosis, Pneumocystosis, Cryptococcosis, Listeriosis, Nocardiosis, Aspergillosis, Coccidioidomycosis, Histoplasmosis, Blastomycosis, Strongyloides, Leishmaniosis, Cryptoporidium, Trypanosoma cruzi, JVC and other prion viruses. These diagnoses were identified by the presence in primary and secondary diagnosis of their ICD9 codes. The population at risk was estimated through the population census of the National Institute of Statistics, with an estimated prevalence of RA of 0.5% in both sexes (0.2% in men and 0.8% in women). Crude and adjusted rates were calculated at the national level. The trend was analyzed by Generalized Linear Models (GLM) using the year variable as the analysis variable. Clinical-demographic factors associated with these infections were analyzed, using uni and multivariate logistic regression. Results Of the total of 338,343 hospital admissions in patients with RA during the 17 years of the study period, there were 4,097 (1.2%) admissions with opportunistic infection, 1591 (38.8%) in men and 2506 (61.2%) in women (p Conclusion In Spain, during the period 1999 to 2015, there has been an increase in the incidence rate of OI in patients with RA. We estimate an annual increase of 4,9%. Being male and having COPD or liver disease are associated with OI. Disclosure of Interests None declared

When over-acceleration and adaptation effects are present in traffic situations which involve a mixture of vehicle classes, microscopic effects translate in the appearance of interesting traffic patterns, including the synchronized flow phase. The establishment of this situation has been studied in the literature. The aim of the present work is to compare numerically two different kinetic based models for a two-class system of aggressive drivers. Model I considers the adaptation effect whereas Model II does not allow its presence. As far as a numerical comparison concerns, it is only in Model I where traffic breakdown appears.

[Goal]: To evaluate the effect of yogurt supplemented with probiotic bacteria on the prevention of antibiotic-associated diarrhea (AAD) in hospitalized patients., [Background]: Diarrhea following antibiotic administration is a frequent clinical problem. The usefulness of probiotics for the prevention of AAD in the hospitalized adult population remains unclear., [Study]: A randomized, double-blind, placebo-controlled clinical trial was conducted in hospitalized patients who started antibiotic treatment. Patients were randomized (2:2:1) to receive a daily amount of 200 mL of placebo-yogurt (Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus), 200 mL of probiotic yogurt (previous plus Lactobacillus acidophilus La-5, Bifidobacterium animalis subsp. lactis Bb-12 and Lactobacillus casei subsp. casei Lc-01 or no yogurt (unblinded control) within 48 hours of beginning the antibiotic therapy and up to 5 days after stopping the antibiotic. Patients were followed up with for 1 month to determine occurrence of diarrhea., [Results]: We included 314 patients, mean age 76 years. The rate of diarrhea was 23.0% in the probiotic group versus 17.6% in the placebo group, absolute risk reduction −5.35% (95% confidence interval, −15.4% to 4.7%; P=0.30). Rate of diarrhea was similar in the unblinded external control and in the blinded study groups combined (20.9% vs. 20.2% respectively; P=0.91). There was no difference in the duration of diarrhea, maximum number of bowel movements or prolonged admission because of diarrhea among the groups. All-cause mortality did not differ between groups., [Conclusions]: The combined probiotic strains LA-5, BB-12, and LC-01 do not have an effect in the prevention of AAD in hospitalized patients., This work was funded by grant AGL2004-07285-C02 of Spanish Ministry of Science.

Recent applications of a new methodology to measure fundamental traffic relations on freeways shows that many critical parameters of the flow-density and speed-spacing diagrams depend on vehicle length. In response to this fact, this work presents a generalization of the Prigogine–Herman traffic equation for aggressive drivers which takes into account the fact that vehicles are not point-like objects but have an effective length. Our approach is similar to that introduced by Enskog for dense gases and provides the construction of fundamental diagrams which are in excellent agreement with empirical traffic data.

Background: This study involves analysis of the relationship between variables obtained using diffusion tensor imaging (DTI) and motor outcome in gliomas adjacent to the corticospinal tract (CST). Methods: Histologically confirmed glioma patients who were to undergo surgery between January 2018 and December 2019 were prospectively enrolled. All patients had a preoperative magnetic resonance imaging (MRI) study that included DTI, a tumor 2 cm or less from the CST, and postsurgical control within 48 h. Patients with MRI that was performed at other center, tumors with primary and premotor cortex invasion, postsurgical complications directly affecting motor outcome and tumor progression Results: Eleven patients were analyzed, and six corresponded to high-grade gliomas and five to low-grade gliomas. Four patients had previous motor impairment and seven patients had postsurgical motor deficits (four transient and three permanent). An FA ratio of 0.8 between peritumoral CST regions and the contralateral hemisphere was found to be the cutoff, and lower values were obtained in patients with permanent motor deficits. Conclusion: Quantitative analysis of DTI that was performed in the immediate postsurgery period can provide valuable information about the motor prognosis after surgery for gliomas near the CST.