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735 results on '"Matsui, Hirofumi"'

151. Neurovascular Unit Protection From Cerebral Ischemia–Reperfusion Injury by Radical-Containing Nanoparticles in Mice

Author

Hosoo, Hisayuki, primary, Marushima, Aiki, additional, Nagasaki, Yukio, additional, Hirayama, Aki, additional, Ito, Hiromu, additional, Puentes, Sandra, additional, Mujagic, Arnela, additional, Tsurushima, Hideo, additional, Tsuruta, Wataro, additional, Suzuki, Kensuke, additional, Matsui, Hirofumi, additional, Matsumaru, Yuji, additional, Yamamoto, Tetsuya, additional, and Matsumura, Akira, additional

Published
2017
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164. Anticancer effect of linaloolviacancer-specific hydroxyl radical generation in human colon cancer

Author

Iwasaki, Kenichi, primary, Zheng, Yun-Wen, additional, Murata, Soichiro, additional, Ito, Hiromu, additional, Nakayama, Ken, additional, Kurokawa, Tomohiro, additional, Sano, Naoki, additional, Nowatari, Takeshi, additional, Villareal, Myra O, additional, Nagano, Yumiko N, additional, Isoda, Hiroko, additional, Matsui, Hirofumi, additional, and Ohkohchi, Nobuhiro, additional

Published
2016
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172. Synthesis, Photophysical Properties, and Biological Evaluation of trans-Bisthioglycosylated Tetrakis(fluorophenyl)chlorin for Photodynamic Therapy

Author

Hirohara, Shiho, primary, Oka, Chio, additional, Totani, Masayasu, additional, Obata, Makoto, additional, Yuasa, Junpei, additional, Ito, Hiromu, additional, Tamura, Masato, additional, Matsui, Hirofumi, additional, Kakiuchi, Kiyomi, additional, Kawai, Tsuyoshi, additional, Kawaichi, Masashi, additional, and Tanihara, Masao, additional

Published
2015
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176. A mitochondrial superoxide theory for oxidative stress diseases and aging

Author

Indo, Hiroko P., primary, Yen, Hsiu-Chuan, additional, Nakanishi, Ikuo, additional, Matsumoto, Ken-ichiro, additional, Tamura, Masato, additional, Nagano, Yumiko, additional, Matsui, Hirofumi, additional, Gusev, Oleg, additional, Cornette, Richard, additional, Okuda, Takashi, additional, Minamiyama, Yukiko, additional, Ichikawa, Hiroshi, additional, Suenaga, Shigeaki, additional, Oki, Misato, additional, Sato, Tsuyoshi, additional, Ozawa, Toshihiko, additional, Clair, Daret K. St., additional, and Majima, Hideyuki J., additional

Published
2015
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193. Transforming growth factor-α stimulates prostaglandin generation through cytosolic phospholipase A2 under the control of p11 in rat gastric epithelial cells

Author

Akiba, Satoshi, Hatazawa, Ryo, Ono, Kyoko, Hayama, Misako, Matsui, Hirofumi, and Sato, Takashi

Subjects
Arachidonic Acid, S100 Proteins, Transforming Growth Factor alpha, Phospholipases A, Cell Line, Rats, Cytosol, Gastric Mucosa, Papers, Prostaglandins, Animals, lipids (amino acids, peptides, and proteins), Calcium, Peptides, Annexin A2, Calcimycin
Abstract

The regulatory effects of transforming growth factor (TGF)-alpha on phospholipase A(2) (PLA(2)) isozymes contributing to prostaglandin generation in rat gastric epithelial RGM1 cells were examined. Stimulation with TGF-alpha for 24 h time-dependently induced prostaglandin E(2) generation with an increase in cyclo-oxygenase-2 protein. The TGF-alpha-induced prostaglandin E(2) generation was suppressed by NS-398, a cyclo-oxygenase-2 inhibitor. TGF-alpha stimulated the activity and the protein synthesis of cytosolic PLA(2) (cPLA(2)). A time-dependent increase in cPLA(2) protein occurred in parallel with PGE(2) generation, which was inhibited by methyl arachidonyl fluorophosphonate (MAFP), a cPLA(2) inhibitor. However, no change in activity of secretory PLA(2) or Ca(+2)-independent PLA(2) was observed in the TGF-alpha-stimulated cells. Stimulation with the Ca(2+) ionophore A23187 for 10 min induced MAFP-sensitive arachidonic acid liberation. Interestingly, preincubation with TGF-alpha for 24 h diminished A23187-stimulated arachidonic acid liberation despite the increase in cPLA(2) protein. Under the conditions, TGF-alpha was found to increase p11, an endogenous cPLA(2) suppressor, also known as annexin II light chain. The TGF-alpha-induced increase in p11 was suppressed by tyrphostin AG1478, an inhibitor of tyrosine kinase of epidermal growth factor receptor, which was also found to restore the inhibition by TGF-alpha of A23187-stimulated arachidonic acid liberation. However, TGF-alpha did not alter protein levels of annexin II heavy chain. These results suggest that TGF-alpha stimulates prostaglandin generation through an increase in cPLA(2), the hydrolytic action of which may be under the control of p11.

Published
2000

198. Comparison of in vivo and in vitro antioxidative parameters for eleven food factors

Author

Indo, Hiroko P., primary, Nakanishi, Ikuo, additional, Ohkubo, Kei, additional, Yen, Hsiu-Chuan, additional, Nyui, Minako, additional, Manda, Sushma, additional, Matsumoto, Ken-ichiro, additional, Fukuhara, Kiyoshi, additional, Anzai, Kazunori, additional, Ikota, Nobuo, additional, Matsui, Hirofumi, additional, Minamiyama, Yukiko, additional, Nakajima, Akira, additional, Ichikawa, Hiroshi, additional, Fukuzumi, Shunichi, additional, Ozawa, Toshihiko, additional, Mukai, Chiaki, additional, and Majima, Hideyuki J., additional

Published
2013
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200. Cancer cells uptake porphyrinsviaheme carrier protein 1

Author

Hiyama, Kazuhiro, primary, Matsui, Hirofumi, additional, Tamura, Masato, additional, Shimokawa, Osamu, additional, Hiyama, Mariko, additional, Kaneko, Tsuyoshi, additional, Nagano, Yumiko, additional, Hyodo, Ichinosuke, additional, Tanaka, Junko, additional, Miwa, Yoshihiro, additional, Ogawa, Tetsuo, additional, Nakanishi, Takeo, additional, and Tamai, Ikumi, additional

Published
2013
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