7,044 results on '"Mazzaferro, A"'
Search Results
152. Liver resection for perihilar cholangiocarcinoma: Impact of biliary drainage failure on postoperative outcome. Results of an Italian multicenter study
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Giuliante, Felice, Ardito, Francesco, Aldrighetti, Luca, Ferrero, Alessandro, Pinna, Antonio D., De Carlis, Luciano, Cillo, Umberto, Jovine, Elio, Portolani, Nazario, Gruttadauria, Salvatore, Mazzaferro, Vincenzo, Massani, Marco, Rosso, Edoardo, Ettorre, Giuseppe M., Ratti, Francesca, Guglielmi, Alfredo, Cescon, Matteo, Colasanti, Marco, Di Sandro, Stefano, Gringeri, Enrico, Russolillo, Nadia, Ruzzenente, Andrea, Sposito, Carlo, Zanello, Matteo, and Zimmitti, Giuseppe
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- 2021
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153. Negative Online Ratings of Joint Replacement Surgeons: An Analysis of 6,402 Reviews
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Imbergamo, Casey, Brzezinski, Andrzej, Patankar, Aneesh, Weintraub, Matthew, Mazzaferro, Natale, and Kayiaros, Stephen
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- 2021
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154. The Italian Consensus on minimally invasive simultaneous resections for synchronous liver metastasis and primary colorectal cancer: A Delphi methodology
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Rocca, Aldo, Cipriani, Federica, Belli, Giulio, Berti, Stefano, Boggi, Ugo, Bottino, Vincenzo, Cillo, Umberto, Cescon, Matteo, Cimino, Matteo, Corcione, Francesco, De Carlis, Luciano, Degiuli, Maurizio, De Paolis, Paolo, De Rose, Agostino Maria, D’Ugo, Domenico, Di Benedetto, Fabrizio, Elmore, Ugo, Ercolani, Giorgio, Ettorre, Giuseppe M., Ferrero, Alessandro, Filauro, Marco, Giuliante, Felice, Gruttadauria, Salvatore, Guglielmi, Alfredo, Izzo, Francesco, Jovine, Elio, Laurenzi, Andrea, Marchegiani, Francesco, Marini, Pierluigi, Massani, Marco, Mazzaferro, Vincenzo, Mineccia, Michela, Minni, Francesco, Muratore, Andrea, Nicosia, Simone, Pellicci, Riccardo, Rosati, Riccardo, Russolillo, Nadia, Spinelli, Antonino, Spolverato, Gaya, Torzilli, Guido, Vennarecci, Giovanni, Viganò, Luca, Vincenti, Leonardo, Delrio, Paolo, Calise, Fulvio, and Aldrighetti, Luca
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- 2021
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155. Natural ventilation potential from weather analyses and building simulation
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Sakiyama, N.R.M., Mazzaferro, L., Carlo, J.C., Bejat, T., and Garrecht, H.
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- 2021
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156. The Impact of Covid-19 Lockdown on Stroke Admissions and Treatments in Campania
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Candelaresi, Paolo, Manzo, Valentino, Servillo, Giovanna, Muto, Mario, Barone, Paolo, Napoletano, Rosa, Saponiero, Renato, Andreone, Vincenzo, Palma, Vincenzo, Spitaleri, Daniele, D'Onofrio, Florindo, Maniscalco, Giorgia, Salvatore, Simona, Leone, Giuseppe, Capone, Elisa, Schettino, Carla, Romano, Daniele, Martusciello, Gioacchino, Miniello, Stefania, Mazzaferro, Maria Pia, and Ascione, Salvatore
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- 2021
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157. Renal resistive index in IgA nephropathy and renal scleroderma vasculopathy
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Cianci, Rosario, Gigante, Antonietta, Bagordo, Domenico, Pintus, Giovanni, Giovannetti, Antonello, Lai, Silvia, Mazzaferro, Sandro, and Rosato, Edoardo
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- 2021
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158. Recommended calcium intake in adults and children with chronic kidney disease-a European consensus statement
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Evenepoel, Pieter, Jørgensen, Hanne Skou, Bover, Jordi, Davenport, Andrew, Bacchetta, Justine, Haarhaus, Mathias, Hansen, Ditte, Gracia-Iguacel, Carolina, Ketteler, Markus, McAlister, Louise, White, Emily, Mazzaferro, Sandro, Vervloet, Marc, Shroff, Rukshana, Evenepoel, Pieter, Jørgensen, Hanne Skou, Bover, Jordi, Davenport, Andrew, Bacchetta, Justine, Haarhaus, Mathias, Hansen, Ditte, Gracia-Iguacel, Carolina, Ketteler, Markus, McAlister, Louise, White, Emily, Mazzaferro, Sandro, Vervloet, Marc, and Shroff, Rukshana
- Abstract
Mineral and bone disorders (MBD) are common in patients with chronic kidney disease (CKD), contributing to significant morbidity and mortality. For several decades, the first-line approach to controlling hyperparathyroidism in CKD was by exogenous calcium loading. Since the turn of the millennium, however, a growing awareness of vascular calcification risk has led to a paradigm shift in management and a move away from calcium-based phosphate binders. As a consequence, contemporary CKD patients may be at risk of a negative calcium balance, which, in turn, may compromise bone health, contributing to renal bone disease and increased fracture risk. A calcium intake below a certain threshold may be as problematic as a high intake, worsening the MBD syndrome of CKD, but is not addressed in current clinical practice guidelines. The CKD-MBD and European Renal Nutrition working groups of the European Renal Association (ERA), together with the CKD-MBD and Dialysis working groups of the European Society for Pediatric Nephrology (ESPN), developed key evidence points and clinical practice points on calcium management in children and adults with CKD across stages of disease. These were reviewed by a Delphi panel consisting of ERA and ESPN working groups members. The main clinical practice points include a suggested total calcium intake from diet and medications of 800–1000 mg/day and not exceeding 1500 mg/day to maintain a neutral calcium balance in adults with CKD. In children with CKD, total calcium intake should be kept within the age-appropriate normal range. These statements provide information and may assist in decision-making, but in the absence of high-level evidence must be carefully considered and adapted to individual patient needs., Mineral and bone disorders (MBD) are common in patients with chronic kidney disease (CKD), contributing to significant morbidity and mortality. For several decades, the first-line approach to controlling hyperparathyroidism in CKD was by exogenous calcium loading. Since the turn of the millennium, however, a growing awareness of vascular calcification risk has led to a paradigm shift in management and a move away from calcium-based phosphate binders. As a consequence, contemporary CKD patients may be at risk of a negative calcium balance, which, in turn, may compromise bone health, contributing to renal bone disease and increased fracture risk. A calcium intake below a certain threshold may be as problematic as a high intake, worsening the MBD syndrome of CKD, but is not addressed in current clinical practice guidelines. The CKD-MBD and European Renal Nutrition working groups of the European Renal Association (ERA), together with the CKD-MBD and Dialysis working groups of the European Society for Pediatric Nephrology (ESPN), developed key evidence points and clinical practice points on calcium management in children and adults with CKD across stages of disease. These were reviewed by a Delphi panel consisting of ERA and ESPN working groups members. The main clinical practice points include a suggested total calcium intake from diet and medications of 800-1000 mg/day and not exceeding 1500 mg/day to maintain a neutral calcium balance in adults with CKD. In children with CKD, total calcium intake should be kept within the ; on behalf of European Renal Osteodystrophy (EUROD), an initiative of the Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) and the European Renal Nutrition (ERN) Working Groups of the European Renal Association (ERA) and the European Society of Pediatric Nephrology (ESPN) age-appropriate normal range. These statements provide information and may assist in decision-making, but in the absence of high-level evidence must be carefully consi
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- 2024
159. Indocyanine Green Fluorescence-Guided Surgery for Gastrointestinal Tumors: A Systematic Review
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Carlo Sposito, MD, Marianna Maspero, MD, Paolo Belotti, MD, Nicolò Simonotti, MD, Michele Altomare, MD, Paolo Ciana, PhD, and Vincenzo Mazzaferro, MD, PhD
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Surgery ,RD1-811 - Abstract
Objective:. To conduct a systematic review of the currently available literature on the use of ICG to guide surgical dissection in gastrointestinal (GI) cancer surgery. Background:. Real-time indocyanine green (ICG) fluorescence-guided surgery has the potential to enhance surgical outcomes by increasing patient-tailored oncological precision. Methods:. MEDLINE, PubMed, EMBASE, and Google Scholar were searched for publications on the use of ICG as a contrast agent in GI cancer surgery until December 2020. Perfusion studies were excluded. Quality of the studies was assessed with the Methodological Index for nonrandomized Studies or Jadad scale for randomized controlled trials. A narrative synthesis of the results was provided, with descriptive statistics when appropriate. Results:. Seventy-eight studies were included. ICG was used for primary tumor and metastases localization, for sentinel lymph node detection, and for lymph flow mapping. The detection rate for primary colorectal and gastric tumors was 100% after preoperative ICG endoscopic injection. For liver lesions, the detection rate after intravenous ICG infusion was 80% and up to 100% for lesions less than 8 mm from the liver surface. The detection rate for sentinel lymph nodes was 89.8% for esophageal, 98.6% for gastric, 87.4% for colorectal, and 83.3% for anal tumors, respectively. In comparative studies, ICG significantly increases the quality of D2 lymphadenectomy in oncological gastrectomy. Conclusion:. The use of ICG as a guiding tool for dissection in GI surgery is promising. Further evidence from high-quality studies on larger sample sizes is needed to assess whether ICG-guided surgery may become standard of care.
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- 2022
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160. Malakoplakia of the urinary bladder: A review of the literature
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Giordano Polisini, Rocco Francesco Delle Fave, Camilla Capretti, Angelo Marronaro, Alessia Mariagrazia Costa, Luigi Quaresima, Daniele Mazzaferro, and Andrea Benedetto Galosi
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malakoplakia ,rare disorder ,urinary tract infection ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Objective: The aim of the study is to make a review of the literature about bladder malakoplakia. Material and Methods: We searched articles on the PUBMED web-literature database with the following keywords: “vesical malakoplakia” and “bladder malakoplakia”. In the literature we found 254 articles. At final we have excluded 219 articles, including in our study only 35 articles. Results: The overall average age found was 50.85 years. The average age of men was 43.22 years, while that of women was 53.37 years. 75% of the patient cases were women and 25% were men. Regarding comorbidities, in 5.55% of the cases were missing whereas 47.22% of the patients suffered from recurrent urinary tract infection (UTI) and 19.44% from immune system disorders. Urine culture was positive in 69.44% with E.coli being isolated in 92% of cases. Hydroureteronephrosis was present in 44.44% of the cases: left in 6.25% of cases, right in 18.75% and bilateral in 75%. The mean serum creatinine of patients with hydroureteronephrosis was 5.11 (1-21) mg/dl. The most frequent site of the lesion was the vesicoureteral junction (VUJ) (42.31%), followed by the trigone (38.46%). 30.56% of patients were treated with antibiotic and surgery (transurethral resection of bladder, partial or radical cystectomy), less frequent options were antibiotics alone and surgery alone. The recurrence rate was 15%. Conclusions: Malakoplakia is a disorder usually related to other affections, like UTI and immunodepression, and it seem to be caused by an abnormal macrophage function. In almost half of the described cases of isolated bladder malakoplakia, hydroureteronephrosis and renal failure were present.Treatment is not standardized, but both medical and surgical therapies are effective to avoid recurrence.
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- 2022
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161. Thoracic Duct Lymphovenous Bypass: A Preliminary Case Series, Surgical Techniques, and Expected Physiologic Outcomes
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Toyoda, Yoshiko, Fowler, Cody, Mazzaferro, Daniel M., McGraw, J. Reed, Othman, Sammy, Azoury, Said C., Itkin, Maxim, and Kovach, Stephen J.
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- 2022
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162. Negative Online Ratings of Joint Replacement Surgeons: An Analysis of 6,402 Reviews
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Casey Imbergamo, BS, Andrzej Brzezinski, MD, Aneesh Patankar, BS, Matthew Weintraub, BS, Natale Mazzaferro, BS, and Stephen Kayiaros, MD
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Online ,Ratings ,Reviews ,Patient ,Satisfaction ,Arthroplasty ,Orthopedic surgery ,RD701-811 - Abstract
Background: With the expanding accessibility of online health-care information, patients frequently report visiting physician rating websites before choosing a surgeon. As such, it is important to analyze patients’ perception of arthroplasty surgeons as reflected on physician rating websites. Methods: A total of 6402 online reviews of arthroplasty surgeons were extracted for analysis. Each review rated less than 5 on a 5-point scale was deemed a “negative” review and was subsequently assigned to an appropriate category. Reviews were stratified by practice type, years in practice, gender, and low ( 3) ratings. Results: A total of 6402 reviews comprising 315 physicians were included in the analysis. The average rating for all surgeons was 4.35. The average rating for physicians in private practice was 4.3, compared to 4.5 for those in an academic setting. The average rating for physicians in practice for 1-10 years was 4.46, compared to 4.03 for those with >10 years of experience (P < .001). The most common factors contributing to negative reviews were bedside manner, wait time, poor outcome, and surgeon proficiency. Surgeon-dependent factors were more commonly associated with lower rated reviews (P < .001). Conclusions: Arthroplasty surgeons typically receive high online ratings, with a mean of 4.35 on a 5-point scale. Physicians in academic practice received higher ratings than those in private practice, and physicians who have been in practice for 1-10 years received higher ratings than those with more than 10 years in practice. The most common factors contributing to negative reviews are surgeon-dependent, including bedside manner, poor outcome, and surgeon proficiency.
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- 2021
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163. Translanguaging as Everyday Practice. An Introduction
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Mazzaferro, Gerardo, Kirkpatrick, Andy, Series Editor, Adamson, Bob, Series Editor, and Mazzaferro, Gerardo, editor
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- 2018
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164. Language Maintenance and Shift Within New Linguistic Minorities in Italy: A Translanguaging Perspective
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Mazzaferro, Gerardo, Kirkpatrick, Andy, Series Editor, Adamson, Bob, Series Editor, and Mazzaferro, Gerardo, editor
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- 2018
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165. D139. Aesthetic and Functional Outcomes following Reconstruction of Mohs Defects of the Lip: Analysis of 417 Cases
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J. Reed McGraw, BS, Annika Deitermann, BS, Stephanie K. Lin, BA, Carolyn Stull, MD, Daniel M. Mazzaferro, MD, MBA, Charles A. Messa, IV, MBA, Corey M. Bascone, MD, MBA, Robyn B. Broach, PhD, H. William Higgins, MD, MBE, Stephen J. Kovach, III, MD, and Christopher J. Miller, MD
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Surgery ,RD1-811 - Published
- 2023
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166. Assessment of therapy response to Regorafenib by 18F-DOPA-PET/CT in patients with recurrent high-grade gliomas: a case series
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Di Giorgio, Eugenio, Cuocolo, Alberto, Mansi, Luigi, Sicignano, Marilena, Squame, Fiorenzo, Gaudieri, Valeria, Giordano, Pasqualina, Giugliano, Francesca Maria, Mazzaferro, Maria Pia, Negro, Alberto, Villa, Alessandro, and Spadafora, Marco
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- 2021
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167. Peculiarities and systematics of microbial diglycosidases, and their applications in food technology
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Baglioni, Micaela, Breccia, Javier D., and Mazzaferro, Laura S.
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- 2021
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168. Focal Update on Immunotherapy and Liver Transplantation in the Era of Transplant Oncology.
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Abdelrahim, Maen, Esmail, Abdullah, Hibi, Taizo, and Mazzaferro, Vincenzo
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CIRCULATING tumor DNA ,IMMUNE checkpoint inhibitors ,CANCER relapse ,LIVER transplantation ,CANCER treatment - Abstract
Transplant oncology is an expanding area of cancer therapy that specifically emphasizes the use of liver transplantation (LT) as the preferred treatment for patients with manageable, but unresectable, tumors. The management and optimization of overall survival strategies, accompanied by an arguably decent quality of life, have been at the forefront of liver oncology treatment, as a plurality of all primary liver cancers are identified as either hepatocellular carcinoma (HCC) or cholangiocarcinoma (CCA), which are classified as highly aggressive malignancies and frequently remain asymptomatic until they progress to advanced stages, rendering curative procedures, such as resection, impractical. This has led to an increase in utilization of neoadjuvant interventions conducted prior to surgery, which has yielded favorable outcomes. Though this treatment modality has prompted further investigations into the efficacy of immune checkpoint inhibitors (ICPIs) as standalone treatments and in combination with locoregional treatments (LRTs) to bridge more patients into curative eligibility. This multidisciplinary methodology and treatment planning has seen multiple successful trials of immunotherapy regimes and combinate treatments, setting the groundwork for increasing eligibility through downstaging and "bridging" previously ineligible patients within stringent LT criteria. Surveillance after LT is a crucial component of transplant oncology. The emergence of circulating tumor DNA (ctDNA) has provided a novel approach to identifying the recurrence of cancer in its early stages. Recent research has focused on liquid biopsy, a technique that effectively identifies the dynamics of cancer. This is another innovation to demonstrate the rate at which transplant oncology is rapidly advancing, making the focus of care feel disorienting. Modalities of care are constantly evolving, but when a field is changing as rapidly as this one, it is imperative to reorient to the data and the needs of the patients. In this commentary, we reflect on the update's utilization of ICPIs in neoadjuvant settings as well as the updates on the utilization of liquid biopsy in post-LT follow-up surveillance. [ABSTRACT FROM AUTHOR]
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- 2024
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169. Pathological Characteristics, Management, and Prognosis of Rectal Neuroendocrine Tumors: A Retrospective Study from a Tertiary Hospital.
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Cavalcoli, Federica, Rausa, Emanuele, Ferrari, Davide, Rosa, Roberto, Maccauro, Marco, Pusceddu, Sara, Sabella, Giovanna, Cantù, Paolo, Vitellaro, Marco, Coppa, Jorgelina, and Mazzaferro, Vincenzo
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PROGRESSION-free survival ,RECTUM tumors ,OVERALL survival ,NEUROENDOCRINE tumors ,ENDOSCOPIC surgery - Abstract
Background: Rectal neuroendocrine tumors (rNENs) are rare, constituting 1–2% of rectal tumors, and are often asymptomatic, leading to challenges in early diagnosis. Current management guidelines recommend endoscopic resection for small lesions and surgical intervention for larger or high-risk tumors. This study aims to retrospectively analyze the pathological characteristics, management, and prognosis of rNEN patients. Methods: Data from the Neuroendocrine Tumor Registry at a tertiary hospital in Milan, Italy from 2005 to 2023 were retrospectively analyzed. Patient demographics, disease characteristics, pathology findings, treatment details, and surveillance data were collected. Statistical analyses included descriptive statistics, multivariable binary logistic regression, and Kaplan–Meier survival analysis. Results: Forty-five patients were included, 53.3% male with a mean age of 57.5 years. Most patients were asymptomatic, with incidental diagnosis during colonoscopy. Endoscopic excision was the primary treatment modality (77.8%), with surgical resection reserved for incomplete or inappropriate endoscopic resections. Disease progression occurred in 13 patients (28.9%), with tumor-related mortality of 22.2%. Kaplan–Meier analysis showed 5- and 10-year survival rates of 68.8% and 59.1%, respectively, with corresponding progression-free survival rates of 72.8% and 54.0%. Tumor stage was significantly associated with disease progression on multivariable analysis (OR = 7.230, p = 0.039). Conclusions: This study highlights the heterogeneous presentation and prognosis of rNENs, with a substantial proportion diagnosed incidentally. Endoscopic management was predominantly utilized, aligning with current guidelines for localized tumors. Tumor stage emerged as a significant predictor of disease progression, emphasizing the importance of accurate staging for optimal management. Further research is warranted to refine management protocols and validate these findings. [ABSTRACT FROM AUTHOR]
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- 2024
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170. Vertebral fractures in patients with CKD and the general population: a call for diagnosis and action.
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Gifre, Laia, Massó, Elisabet, Fusaro, Maria, Haarhaus, Mathias, Ureña, Pablo, Cozzolino, Mario, Mazzaferro, Sandro, Calabia, Jordi, Peris, Pilar, and Bover, Jordi
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VERTEBRAL fractures ,BONE density ,RENAL replacement therapy ,PROGNOSIS ,VITAMIN D deficiency - Abstract
Vertebral fractures (VFs) are the most common osteoporotic fractures in the general population, and they have been associated with high mortality, decreased quality of life, and high risk of subsequent fractures, especially when recent, multiple, or severe. Currently, VF diagnosis and classification determine fracture risk and the most appropriate anti-osteoporotic treatment. However, VFs are clearly underdiagnosed, especially in patients with chronic kidney disease (CKD), and CKD-associated osteoporosis has been disregarded until recently. VFs are associated with higher morbidity and mortality, and their prevalence and incidence differ depending on the grade of renal dysfunction (CKD G1–G5) and/or the type of renal replacement therapy (dialysis or transplantation). In addition to classical risk factors [such as higher age, female sex, reduced bone mineral density, diabetes and steroid use], various other factors have been associated with an increased risk of VFs in CKD, including CKD grade, haemodialysis vintage, time since renal transplantation, low or high intact parathyroid hormone and phosphate levels, and/or vitamin D and K
1 deficiencies. Importantly, several clinical societies have recently modified their algorithms according to the fracture risk classification (including the presence of VFs) and determined the most appropriate anti-osteoporotic treatment for the general population. However, there are no specific guidelines addressing this topic in patients with CKD despite an important paradigm shift regarding the prognostic value of bone mineral density in 2017 after the publication of the CKD-Mineral and Bone Disorder Kidney Disease: Improving Global Outcomes guidelines. A proactive attitude towards diagnosis, treatment, and research is proposed to avoid therapeutic nihilism. [ABSTRACT FROM AUTHOR]- Published
- 2024
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171. Amphiphilic Polyelectrolyte Complexes for Fouling-Resistant and Easily Tunable Membranes.
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Mazzaferro, Luca, Grasseschi, Teresa M., Like, Bricker D., Panzer, Matthew J., and Asatekin, Ayse
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- 2024
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172. Decamethyl-pillar[5]arene: Synthesis and Recognition Properties.
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Crisafulli, Daniele, Savoca, Giulia, Mancuso, Francesca, Mazzaferro, Martina, Milone, Marco, Pisagatti, Ilenia, Notti, Anna, Parisi, Melchiorre F., and Gattuso, Giuseppe
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- 2024
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173. Structural bases for stoichiometry‐selective calcium potentiation of a neuronal nicotinic receptor.
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Mazzaferro, Simone, Kang, Guipeun, Natarajan, Kathiresan, Hibbs, Ryan E., and Sine, Steven M.
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NICOTINIC receptors , *CALCIUM channels , *PATCH-clamp techniques (Electrophysiology) , *TRANSMEMBRANE domains , *CALCIUM , *CALCIUM ions , *BINDING sites - Abstract
Background and Purpose: α4β2 nicotinic acetylcholine (nACh) receptors assemble in two stoichiometric forms, one of which is potentiated by calcium. The sites of calcium binding that underpin potentiation are not known. Experimental Approach: To identify calcium binding sites, we applied cryo‐electron microscopy (cryo‐EM) and molecular dynamics (MD) simulations to each stoichiometric form of the α4β2 nACh receptor in the presence of calcium ions. To test whether the identified calcium sites are linked to potentiation, we generated mutants of anionic residues at the sites, expressed wild type and mutant receptors in clonal mammalian fibroblasts, and recorded ACh‐elicited single‐channel currents with or without calcium. Key Results: Both cryo‐EM and MD simulations show calcium bound to a site between the extracellular and transmembrane domains of each α4 subunit (ECD‐TMD site). Substituting alanine for anionic residues at the ECD‐TMD site abolishes stoichiometry‐selective calcium potentiation, as monitored by single‐channel patch clamp electrophysiology. Additionally, MD simulation reveals calcium association at subunit interfaces within the extracellular domain. Substituting alanine for anionic residues at the ECD sites reduces or abolishes stoichiometry‐selective calcium potentiation. Conclusions and Implications: Stoichiometry‐selective calcium potentiation of the α4β2 nACh receptor is achieved by calcium association with topographically distinct sites framed by anionic residues within the α4 subunit and between the α4 and β2 subunits. Stoichiometry‐selective calcium potentiation could result from the greater number of calcium sites in the stoichiometric form with three rather than two α4 subunits. The results are relevant to modulation of signalling via α4β2 nACh receptors in physiological and pathophysiological conditions. [ABSTRACT FROM AUTHOR]
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- 2024
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174. Adjunct Procedures Related to Mandibular Reconstruction and Soft Tissue Facial Improvement
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Mazzaferro, Daniel, Naran, Sanjay, Bartlett, Scott, Reinisch, John F., editor, and Tahiri, Youssef, editor
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- 2019
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175. Oxygen extraction ratio to identify patients at increased risk of intradialytic hypotension
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Silverio Rotondi, Lida Tartaglione, Natalia De Martini, Domenico Bagordo, Sara Caissutti, Marzia Pasquali, Maria Luisa Muci, and Sandro Mazzaferro
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Medicine ,Science - Abstract
Abstract Intradialytic hypotension (IDH) is a hemodynamic phenomenon recently associated with decreased blood oxygen saturation (SO2). The ratio between peripheral oxygen saturation (SpO2) and central venous SO2 (ScvO2) or Oxygen Extraction Ratio (OER), which represents a roughly estimate of the amount of oxygen claimed by peripheral tissues, might be used to estimate haemodialysis (HD) related hypoxic stress. Aim of this pilot study was to evaluate the relationship between OER increments during dialysis sessions (ΔOER) and episodes of IDH. We enrolled chronic HD patients with permanent central venous catheter (CVC) and no fistula, in whom ScvO2 measurement is at hand. OER ([(SpO2 − ScvO2)/SpO2] × 100) was measured in three consecutive HD sessions (HD OER sessions) before HD, after 15′, 30′ and 60′ min and at the end of HD. Then, a one-year follow-up was planned to record the number of IDH episodes. In the 28 enrolled patients (age 74 ± 2.6 years), during 12 ± 1.2 months of follow up, incidence of IDH was 3.6%. We divided patients into two groups, above or below the median value of ΔOER at the end of HD, which was 36%. In these groups, the average incidence of IDH was 7% and 2% respectively (p 19% after only 15′ of HD treatment or > 36% at the end of the session characterize patients with higher rates of hypotension. Intradialytic ∆OER, a parameter of tissue hypoxic stress, identifies more fragile patients at greater risk of IDH.
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- 2021
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176. Recurrent convulsive syncope misdiagnosed as seizures due to a diaphragmatic hernia
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Acampora, Roberto, Marte, Gianpaolo, Scala, Rossana, Lieto, Maria, Maida, Pietro, and Mazzaferro, Maria Pia
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- 2021
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177. Posterior Vault Distraction Osteogenesis: Rates of Ossification in Bone Gaps After Consolidation
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Naran, Sanjay, Mazzaferro, Daniel M., Wes, Ari M., Larson, Jordan H., Bartlett, Scott P., and Taylor, Jesse A.
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- 2022
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178. Fouling-Resistant Membranes with Tunable Pore Size Fabricated Using Cross-Linkable Copolymers with High Zwitterion Content
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Samuel J. Lounder, Patrick T. Wright, Luca Mazzaferro, and Ayse Asatekin
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Membranes ,fouling resistant ,zwitterions ,cross-linking ,tunable ,Chemistry ,QD1-999 - Abstract
ABSTRACT: This work describes a new approach for synthesizing extremely fouling-resistant, zwitterionic membranes with controlled, tunable pore sizes that extend from ion separations (< 1 nm) to the ultrafiltration range (∼2 nm). These membranes are manufactured by the UV treatment of high zwitterion content amphiphilic copolymers with cross-linkable functionality to stabilize the membrane selective layers, preventing excessive swelling and dissolution of copolymers containing as high as 80 wt% zwitterionic repeat units. Zwitterion weight fraction allows the tuning of membrane performance, with effective pore size and permeance both increasing with zwitterion content. The high zwitterion content membranes were remarkably fouling-resistant and demonstrated a salt-responsive behavior not previously observed with self-assembling zwitterionic copolymer membranes.
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- 2022
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179. Prediction of the mechanical and failure behavior of metal-composite hybrid joints using cohesive surfaces
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Alessio, Renan Pereira, Andre, Natalia Manente, Goushegir, Seyed M., dos Santos, Jorge F., Mazzaferro, José Antônio E., and Amancio-Filho, Sergio T.
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- 2020
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180. Liver transplantation in hepatocellular carcinoma after tumour downstaging (XXL): a randomised, controlled, phase 2b/3 trial
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Mazzaferro, Vincenzo, Citterio, Davide, Bhoori, Sherrie, Bongini, Marco, Miceli, Rosalba, De Carlis, Luciano, Colledan, Michele, Salizzoni, Mauro, Romagnoli, Renato, Antonelli, Barbara, Vivarelli, Marco, Tisone, Giuseppe, Rossi, Massimo, Gruttadauria, Salvatore, Di Sandro, Stefano, De Carlis, Riccardo, Lucà, Maria Grazia, De Giorgio, Massimo, Mirabella, Stefano, Belli, Luca, Fagiuoli, Stefano, Martini, Silvia, Iavarone, Massimo, Svegliati Baroni, Gianluca, Angelico, Mario, Ginanni Corradini, Stefano, Volpes, Riccardo, Mariani, Luigi, Regalia, Enrico, Flores, Maria, Droz dit Busset, Michele, and Sposito, Carlo
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- 2020
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181. Bone, inflammation and chronic kidney disease
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Mazzaferro, Sandro, De Martini, Natalia, Rotondi, Silverio, Tartaglione, Lida, Ureña-Torres, Pablo, Bover, Jordi, and Pasquali, Marzia
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- 2020
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182. α-lipoic acid in patients with autosomal dominant polycystic kidney disease
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Lai, Silvia, Petramala, Luigi, Muscaritoli, Maurizio, Cianci, Rosario, Mazzaferro, Sandro, Mitterhofer, Anna Paola, Pasquali, Marzia, D'Ambrosio, Viola, Carta, Maria, Ansuini, Matteo, Ramaccini, Cesarina, Galani, Alessandro, Amabile, Maria Ida, Molfino, Alessio, and Letizia, Claudio
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- 2020
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183. Development of a nomogram to predict outcome after liver resection for hepatocellular carcinoma in Child-Pugh B cirrhosis
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Berardi, Giammauro, Morise, Zenichi, Sposito, Carlo, Igarashi, Kazuharu, Panetta, Valentina, Simonelli, Ilaria, Kim, Sungho, Goh, Brian K.P., Kubo, Shoji, Tanaka, Shogo, Takeda, Yutaka, Ettorre, Giuseppe Maria, Wilson, Gregory C., Cimino, Matteo, Chan, Chung-Yip, Torzilli, Guido, Cheung, Tan To, Kaneko, Hironori, Mazzaferro, Vincenzo, Geller, David A., Han, Ho-Seong, Kanazawa, Akishige, Wakabayashi, Go, and Troisi, Roberto Ivan
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- 2020
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184. Indocyanine Green Fluorescence-Guided Surgery for Gastrointestinal Tumors: A Systematic Review
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Sposito, Carlo, Maspero, Marianna, Belotti, Paolo, Simonotti, Nicolò, Altomare, Michele, Ciana, Paolo, and Mazzaferro, Vincenzo
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- 2022
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185. Flanking Domains Modulate α-Synuclein Monomer Structure: A Molecular Dynamics Domain Deletion Study
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Onishi, Noriyo, primary, Mazzaferro, Nicodemo, additional, Kunstelj, Špela, additional, Alvarado, Daisy A., additional, Muller, Anna M., additional, and Vázquez, Frank X., additional
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- 2024
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186. Portal vein thrombosis and liver transplantation: management, matching, and outcomes: a retrospective multicenter cohort study
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Di Benedetto, Fabrizio, primary, Magistri, Paolo, additional, Di Sandro, Stefano, additional, Boetto, Riccardo, additional, Tandoi, Francesco, additional, Camagni, Stefania, additional, Lauterio, Andrea, additional, Pagano, Duilio, additional, Nicolini, Daniele, additional, Violi, Paola, additional, Dondossola, Daniele, additional, Guglielmo, Nicola, additional, Cherchi, Vittorio, additional, Lai, Quirino, additional, Toti, Luca, additional, Bongini, Marco, additional, Frassoni, Samuele, additional, Bagnardi, Vincenzo, additional, Mazzaferro, Vincenzo, additional, Tisone, Giuseppe, additional, Rossi, Massimo, additional, Baccarani, Umberto, additional, Ettorre, Giuseppe Maria, additional, Caccamo, Lucio, additional, Carraro, Amedeo, additional, Vivarelli, Marco, additional, Gruttadauria, Salvatore, additional, De Carlis, Luciano, additional, Colledan, Michele, additional, Romagnoli, Renato, additional, and Cillo, Umberto, additional
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- 2024
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187. In vitro evaluation of the calcification inhibitory properties of Policosanol, Genistein and Vitamin D (Reduplaxin®) either alone or in combination
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Iacobini, Carla, primary, Fassino, Valeria, additional, Mazzaferro, Sandro, additional, and Tartaglione, Lida, additional
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- 2024
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188. NALIRIFOX, FOLFIRINOX, and Gemcitabine With Nab-Paclitaxel as First-Line Chemotherapy for Metastatic Pancreatic Cancer
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Nichetti, Federico, primary, Rota, Simone, additional, Ambrosini, Paolo, additional, Pircher, Chiara, additional, Gusmaroli, Eleonora, additional, Droz Dit Busset, Michele, additional, Pusceddu, Sara, additional, Sposito, Carlo, additional, Coppa, Jorgelina, additional, Morano, Federica, additional, Pietrantonio, Filippo, additional, Di Bartolomeo, Maria, additional, Mariani, Luigi, additional, Mazzaferro, Vincenzo, additional, de Braud, Filippo, additional, and Niger, Monica, additional
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- 2024
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189. Impact of liver cirrhosis, severity of cirrhosis and portal hypertension on the difficulty of laparoscopic and robotic minor liver resections for primary liver malignancies in the anterolateral segments
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Zheng, Junhao, primary, Liang, Xiao, additional, Wu, Andrew G.R., additional, Kabir, Tousif, additional, Scatton, Olivier, additional, Lim, Chetana, additional, Hasegawa, Kiyoshi, additional, Sijberden, Jasper P., additional, Aghayan, Davit L., additional, Siow, Tiing Foong, additional, Dokmak, Safi, additional, Herman, Paulo, additional, Marino, Marco V., additional, Mazzaferro, Vincenzo, additional, Chiow, Adrian K.H., additional, Sucandy, Iswanto, additional, Ivanecz, Arpad, additional, Choi, Sung Hoon, additional, Lee, Jae Hoon, additional, Prieto, Mikel, additional, Vivarelli, Marco, additional, Giuliante, Felice, additional, Ruzzenente, Andrea, additional, Yong, Chee-Chien, additional, Yin, Mengqiu, additional, Chen, Zewei, additional, Fondevila, Constantino, additional, Efanov, Mikhail, additional, Morise, Zenichi, additional, Di Benedetto, Fabrizio, additional, Brustia, Raffaele, additional, Dalla Valle, Raffaele, additional, Boggi, Ugo, additional, Geller, David, additional, Belli, Andrea, additional, Memeo, Riccardo, additional, Gruttadauria, Salvatore, additional, Mejia, Alejandro, additional, Park, James O., additional, Rotellar, Fernando, additional, Choi, Gi-Hong, additional, Robles-Campos, Ricardo, additional, Wang, Xiaoying, additional, Sutcliffe, Robert P., additional, Pratschke, Johann, additional, Lai, Eric C.H., additional, Chong, Charing C.N., additional, D'Hondt, Mathieu, additional, Monden, Kazuteru, additional, Lopez-Ben, Santiago, additional, Kingham, T. Peter, additional, Ferrero, Alessandro, additional, Ettorre, Giuseppe Maria, additional, Cherqui, Daniel, additional, Cipriani, Federica, additional, Soubrane, Olivier, additional, Zhang, Wanguang, additional, Wakabayashi, Go, additional, Troisi, Roberto I., additional, Cheung, Tan-To, additional, Kato, Yutaro, additional, Sugioka, Atsushi, additional, Long, Tran Cong duy, additional, Liu, Rong, additional, Edwin, Bjørn, additional, Fuks, David, additional, Abu Hilal, Mohammad, additional, Chen, Kuo-Hsin, additional, Aldrighetti, Luca, additional, Han, Ho-Seong, additional, Goh, Brian K.P., additional, Syn, Nicholas, additional, Gastaca, Mikel, additional, De Meyere, Celine, additional, Meurs, Juul, additional, Ng, Kelvin K., additional, Lee, Kit-Fai, additional, Tarakanov, Pavel, additional, Alikhanov, Ruslan, additional, Thiruchelvam, Nita, additional, Jang, Jae Young, additional, Kojima, Masayuki, additional, Pirola Kruger, Jaime Arthur, additional, Coelho, Fabricio Ferreira, additional, Lopez-Lopez, Victor, additional, Casellas I Robert, Margarida, additional, Montalti, Roberto, additional, Giglio, Mariano, additional, Lee, Boram, additional, D'Silva, Mizelle, additional, Wang, Hao-Ping, additional, Pascual, Franco, additional, Saleh, Mansour, additional, Yu, Shian, additional, Vani, Simone, additional, Ardito, Francesco, additional, Giustizieri, Ugo, additional, Citterio, Davide, additional, Mocchegiani, Federico, additional, Colasanti, Marco, additional, Berardi, Giammauro, additional, Guzmán, Yoelimar, additional, Labadie, Kevin P., additional, Conticchio, Maria, additional, Dogeas, Epameinondas, additional, Kauffmann, Emanuele F., additional, Giuffrida, Mario, additional, Sommacale, Daniele, additional, Laurent, Alexis, additional, Magistri, Paolo, additional, Mishima, Kohei, additional, Schmelzle, Moritz, additional, Krenzien, Felix, additional, Kadam, Prashant, additional, Tang, Chung-Ngai, additional, Ghotbi, Jacob, additional, Fretland, Åsmund Avdem, additional, Forchino, Fabio, additional, Valle, Bernardo Dalla, additional, Mazzotta, Alessandro, additional, Nghia, Phan Phuoc, additional, Cauchy, Francois, additional, Liu, Qu, additional, and Kawaguchi, Yoshikuni, additional
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- 2024
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190. Dialysate calcium concentration during calcimimetic treatment: a neglected issue
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Locatelli, Francesco, Rotondi, Silverio, Del Vecchio, Lucia, and Mazzaferro, Sandro
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- 2021
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191. Preoperative predictors of liver decompensation after mini-invasive liver resection
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Sposito, Carlo, Monteleone, Michela, Aldrighetti, Luca, Cillo, Umberto, Dalla Valle, Raffaele, Guglielmi, Alfredo, Ettorre, Giuseppe Maria, Ferrero, Alessandro, Di Benedetto, Fabrizio, Rossi, Giorgio Ettore, De Carlis, Luciano, Giuliante, Felice, and Mazzaferro, Vincenzo
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- 2021
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192. Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities
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Huang, Lam O., Rauch, Alexander, Mazzaferro, Eugenia, Preuss, Michael, Carobbio, Stefania, Bayrak, Cigdem S., Chami, Nathalie, Wang, Zhe, Schick, Ursula M., Yang, Nancy, Itan, Yuval, Vidal-Puig, Antonio, den Hoed, Marcel, Mandrup, Susanne, Kilpeläinen, Tuomas O., and Loos, Ruth J. F.
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- 2021
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193. NACHO and 14-3-3 promote expression of distinct subunit stoichiometries of the α4β2 acetylcholine receptor
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Mazzaferro, Simone, Whiteman, Sara T., Alcaino, Constanza, Beyder, Arthur, and Sine, Steven M.
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- 2021
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194. Reproduktionstechnologien: Queere Perspektiven und reproduktive Gerechtigkeit
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Gülden Ediger, Anthea Kyere, Ute Kalender, Valle Mazzaferro
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- 2021
195. Effects of sunitinib on endothelial dysfunction, metabolic changes, and cardiovascular risk indices in renal cell carcinoma
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Silvia Lai, Maria Ida Amabile, Sandro Mazzaferro, Anna Paola Mitterhofer, Angelo Mazzarella, Alessandro Galani, Giovanni Imbimbo, Rosario Cianci, Marzia Pasquali, Alessio Molfino, and Study Group on Geriatric Nephrology of the Italian Society of Nephrology (SIN)
- Subjects
cardiovascular risk ,endothelial dysfunction ,hypertension ,metabolism ,renal cell carcinoma ,renal function ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Sunitinib is a standard treatment for metastatic renal cell carcinoma (RCC). Currently, the data available on the effects of sunitinib on endothelial dysfunction, metabolic changes, and cardiovascular (CV) risk factors are limited, and we aimed to evaluate these aspects in patients with RCC after a short period of treatment. Methods Patients affected by metastatic RCC were enrolled and evaluated before starting sunitinib (T0) and after 40 days of treatment (T1) by the flow‐mediated dilation (FMD), carotid intima media thickness (IMT), ankle‐brachial pressure index (ABI), and 24‐hour proteinuria. We also assessed serum metabolic and nutritional parameters at T0 and T1. Results Twenty patients (7 female), with a mean age of 61.4 ± 12.0 years, were studied. Overtime, we observed a reduction in estimated glomerular filtration rate (P = .002), FMD (P = .001) and in fasting plasma glucose levels (P = .04), as well as an increase in plasma insulin (P
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- 2020
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196. Erratum to: Search for single top-quark production via flavour-changing neutral currents at 8 TeV with the ATLAS detector
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Aad, G., Abbott, B., Abdallah, J., Abdinov, O., Aben, R., Abolins, M., AbouZeid, O. S., Abramowicz, H., Abreu, H., Abreu, R., Abulaiti, Y., Acharya, B. S., Adamczyk, L., Adams, D. L., Adelman, J., Adomeit, S., Adye, T., Affolder, A. A., Agatonovic-Jovin, T., Agricola, J., Aguilar-Saavedra, J. A., Ahlen, S. P., Ahmadov, F., Aielli, G., Akerstedt, H., Åkesson, T. P. A., Akimov, A. V., Alberghi, G. L., Albert, J., Albrand, S., Alconada Verzini, M. J., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexander, G., Alexopoulos, T., Alhroob, M., Alimonti, G., Alio, L., Alison, J., Alkire, S. P., Allbrooke, B. M. M., Allport, P. P., Aloisio, A., Alonso, A., Alonso, F., Alpigiani, C., Altheimer, A., Alvarez Gonzalez, B., Álvarez Piqueras, D., Alviggi, M. G., Amadio, B. T., Amako, K., Amaral Coutinho, Y., Amelung, C., Amidei, D., Amor Dos Santos, S. P., Amorim, A., Amoroso, S., Amram, N., Amundsen, G., Anastopoulos, C., Ancu, L. S., Andari, N., Andeen, T., Anders, C. F., Anders, G., Anders, J. K., Anderson, K. J., Andreazza, A., Andrei, V., Angelidakis, S., Angelozzi, I., Anger, P., Angerami, A., Anghinolfi, F., Anisenkov, A. V., Anjos, N., Annovi, A., Antonelli, M., Antonov, A., Antos, J., Anulli, F., Aoki, M., Aperio Bella, L., Arabidze, G., Arai, Y., Araque, J. P., Arce, A. T. H., Arduh, F. A., Arguin, J-F., Argyropoulos, S., Arik, M., Armbruster, A. J., Arnaez, O., Arnal, V., Arnold, H., Arratia, M., Arslan, O., Artamonov, A., Artoni, G., Asai, S., Asbah, N., Ashkenazi, A., Åsman, B., Asquith, L., Assamagan, K., Astalos, R., Atkinson, M., Atlay, N. B., Augsten, K., Aurousseau, M., Avolio, G., Axen, B., Ayoub, M. K., Azuelos, G., Baak, M. A., Baas, A. E., Baca, M. J., Bacci, C., Bachacou, H., Bachas, K., Backes, M., Backhaus, M., Bagiacchi, P., Bagnaia, P., Bai, Y., Bain, T., Baines, J. T., Baker, O. K., Baldin, E. M., Balek, P., Balestri, T., Balli, F., Banas, E., Banerjee, Sw., Bannoura, A. A. E., Bansil, H. S., Barak, L., Barberio, E. L., Barberis, D., Barbero, M., Barillari, T., Barisonzi, M., Barklow, T., Barlow, N., Barnes, S. L., Barnett, B. M., Barnett, R. M., Barnovska, Z., Baroncelli, A., Barone, G., Barr, A. J., Barreiro, F., Barreiro Guimarães da Costa, J., Bartoldus, R., Barton, A. E., Bartos, P., Basalaev, A., Bassalat, A., Basye, A., Bates, R. L., Batista, S. J., Batley, J. R., Battaglia, M., Bauce, M., Bauer, F., Bawa, H. S., Beacham, J. B., Beattie, M. D., Beau, T., Beauchemin, P. H., Beccherle, R., Bechtle, P., Beck, H. P., Becker, K., Becker, M., Beckingham, M., Becot, C., Beddall, A. J., Beddall, A., Bednyakov, V. A., Bee, C. P., Beemster, L. J., Beermann, T. A., Begel, M., Behr, J. K., Belanger-Champagne, C., Bell, W. H., Bella, G., Bellagamba, L., Bellerive, A., Bellomo, M., Belotskiy, K., Beltramello, O., Benary, O., Benchekroun, D., Bender, M., Bendtz, K., Benekos, N., Benhammou, Y., Benhar Noccioli, E., Benitez Garcia, J. A., Benjamin, D. P., Bensinger, J. R., Bentvelsen, S., Beresford, L., Beretta, M., Berge, D., Bergeaas Kuutmann, E., Berger, N., Berghaus, F., Beringer, J., Bernard, C., Bernard, N. R., Bernius, C., Bernlochner, F. U., Berry, T., Berta, P., Bertella, C., Bertoli, G., Bertolucci, F., Bertsche, C., Bertsche, D., Besana, M. I., Besjes, G. J., Bessidskaia Bylund, O., Bessner, M., Besson, N., Betancourt, C., Bethke, S., Bevan, A. J., Bhimji, W., Bianchi, R. M., Bianchini, L., Bianco, M., Biebel, O., Biedermann, D., Bieniek, S. P., Biglietti, M., Bilbao De Mendizabal, J., Bilokon, H., Bindi, M., Binet, S., Bingul, A., Bini, C., Biondi, S., Black, C. W., Black, J. E., Black, K. M., Blackburn, D., Blair, R. E., Blanchard, J.-B., Blanco, J. E., Blazek, T., Bloch, I., Blocker, C., Blum, W., Blumenschein, U., Bobbink, G. J., Bobrovnikov, V. S., Bocchetta, S. S., Bocci, A., Bock, C., Boehler, M., Bogaerts, J. A., Bogavac, D., Bogdanchikov, A. G., Bohm, C., Boisvert, V., Bold, T., Boldea, V., Boldyrev, A. S., Bomben, M., Bona, M., Boonekamp, M., Borisov, A., Borissov, G., Borroni, S., Bortfeldt, J., Bortolotto, V., Bos, K., Boscherini, D., Bosman, M., Boudreau, J., Bouffard, J., Bouhova-Thacker, E. V., Boumediene, D., Bourdarios, C., Bousson, N., Boveia, A., Boyd, J., Boyko, I. R., Bozic, I., Bracinik, J., Brandt, A., Brandt, G., Brandt, O., Bratzler, U., Brau, B., Brau, J. E., Braun, H. M., Brazzale, S. F., Breaden Madden, W. D., Brendlinger, K., Brennan, A. J., Brenner, L., Brenner, R., Bressler, S., Bristow, K., Bristow, T. M., Britton, D., Britzger, D., Brochu, F. M., Brock, I., Brock, R., Bronner, J., Brooijmans, G., Brooks, T., Brooks, W. K., Brosamer, J., Brost, E., Brown, J., Bruckman de Renstrom, P. A., Bruncko, D., Bruneliere, R., Bruni, A., Bruni, G., Bruschi, M., Bruscino, N., Bryngemark, L., Buanes, T., Buat, Q., Buchholz, P., Buckley, A. G., Buda, S. I., Budagov, I. A., Buehrer, F., Bugge, L., Bugge, M. K., Bulekov, O., Bullock, D., Burckhart, H., Burdin, S., Burgard, C. D., Burghgrave, B., Burke, S., Burmeister, I., Busato, E., Büscher, D., Büscher, V., Bussey, P., Butler, J. M., Butt, A. I., Buttar, C. M., Butterworth, J. M., Butti, P., Buttinger, W., Buzatu, A., Buzykaev, A. R., Cabrera Urbán, S., Caforio, D., Cairo, V. M., Cakir, O., Calace, N., Calafiura, P., Calandri, A., Calderini, G., Calfayan, P., Caloba, L. P., Calvet, D., Calvet, S., Camacho Toro, R., Camarda, S., Camarri, P., Cameron, D., Caminal Armadans, R., Campana, S., Campanelli, M., Campoverde, A., Canale, V., Canepa, A., Cano Bret, M., Cantero, J., Cantrill, R., Cao, T., Capeans Garrido, M. D. M., Caprini, I., Caprini, M., Capua, M., Caputo, R., Cardarelli, R., Cardillo, F., Carli, T., Carlino, G., Carminati, L., Caron, S., Carquin, E., Carrillo-Montoya, G. D., Carter, J. R., Carvalho, J., Casadei, D., Casado, M. P., Casolino, M., Castaneda-Miranda, E., Castelli, A., Castillo Gimenez, V., Castro, N. F., Catastini, P., Catinaccio, A., Catmore, J. R., Cattai, A., Caudron, J., Cavaliere, V., Cavalli, D., Cavalli-Sforza, M., Cavasinni, V., Ceradini, F., Cerio, B. C., Cerny, K., Cerqueira, A. S., Cerri, A., Cerrito, L., Cerutti, F., Cerv, M., Cervelli, A., Cetin, S. A., Chafaq, A., Chakraborty, D., Chalupkova, I., Chang, P., Chapman, J. D., Charlton, D. G., Chau, C. C., Chavez Barajas, C. A., Cheatham, S., Chegwidden, A., Chekanov, S., Chekulaev, S. V., Chelkov, G. A., Chelstowska, M. A., Chen, C., Chen, H., Chen, K., Chen, L., Chen, S., Chen, X., Chen, Y., Cheng, H. C., Cheng, Y., Cheplakov, A., Cheremushkina, E., Cherkaoui El Moursli, R., Chernyatin, V., Cheu, E., Chevalier, L., Chiarella, V., Chiarelli, G., Chiodini, G., Chisholm, A. S., Chislett, R. T., Chitan, A., Chizhov, M. V., Choi, K., Chouridou, S., Chow, B. K. B., Christodoulou, V., Chromek-Burckhart, D., Chudoba, J., Chuinard, A. J., Chwastowski, J. J., Chytka, L., Ciapetti, G., Ciftci, A. K., Cinca, D., Cindro, V., Cioara, I. A., Ciocio, A., Cirotto, F., Citron, Z. H., Ciubancan, M., Clark, A., Clark, B. L., Clark, P. J., Clarke, R. N., Cleland, W., Clement, C., Coadou, Y., Cobal, M., Coccaro, A., Cochran, J., Coffey, L., Cogan, J. G., Colasurdo, L., Cole, B., Cole, S., Colijn, A. P., Collot, J., Colombo, T., Compostella, G., Conde Muiño, P., Coniavitis, E., Connell, S. H., Connelly, I. A., Consorti, V., Constantinescu, S., Conta, C., Conti, G., Conventi, F., Cooke, M., Cooper, B. D., Cooper-Sarkar, A. M., Cornelissen, T., Corradi, M., Corriveau, F., Corso-Radu, A., Cortes-Gonzalez, A., Cortiana, G., Costa, G., Costa, M. J., Costanzo, D., Côté, D., Cottin, G., Cowan, G., Cox, B. E., Cranmer, K., Cree, G., Crépé-Renaudin, S., Crescioli, F., Cribbs, W. A., Crispin Ortuzar, M., Cristinziani, M., Croft, V., Crosetti, G., Cuhadar Donszelmann, T., Cummings, J., Curatolo, M., Cuthbert, C., Czirr, H., Czodrowski, P., D’Auria, S., D’Onofrio, M., Da Cunha Sargedas De Sousa, M. J., Da Via, C., Dabrowski, W., Dafinca, A., Dai, T., Dale, O., Dallaire, F., Dallapiccola, C., Dam, M., Dandoy, J. R., Dang, N. P., Daniells, A. C., Danninger, M., Dano Hoffmann, M., Dao, V., Darbo, G., Darmora, S., Dassoulas, J., Dattagupta, A., Davey, W., David, C., Davidek, T., Davies, E., Davies, M., Davison, P., Davygora, Y., Dawe, E., Dawson, I., Daya-Ishmukhametova, R. K., De, K., de Asmundis, R., De Benedetti, A., De Castro, S., De Cecco, S., De Groot, N., de Jong, P., De la Torre, H., De Lorenzi, F., De Pedis, D., De Salvo, A., De Sanctis, U., De Santo, A., De Vivie De Regie, J. B., Dearnaley, W. J., Debbe, R., Debenedetti, C., Dedovich, D. V., Deigaard, I., Del Peso, J., Del Prete, T., Delgove, D., Deliot, F., Delitzsch, C. M., Deliyergiyev, M., Dell’Acqua, A., Dell’Asta, L., Dell’Orso, M., Della Pietra, M., della Volpe, D., Delmastro, M., Delsart, P. A., Deluca, C., DeMarco, D. A., Demers, S., Demichev, M., Demilly, A., Denisov, S. P., Derendarz, D., Derkaoui, J. E., Derue, F., Dervan, P., Desch, K., Deterre, C., Deviveiros, P. O., Dewhurst, A., Dhaliwal, S., Di Ciaccio, A., Di Ciaccio, L., Di Domenico, A., Di Donato, C., Di Girolamo, A., Di Girolamo, B., Di Mattia, A., Di Micco, B., Di Nardo, R., Di Simone, A., Di Sipio, R., Di Valentino, D., Diaconu, C., Diamond, M., Dias, F. A., Diaz, M. A., Diehl, E. B., Dietrich, J., Diglio, S., Dimitrievska, A., Dingfelder, J., Dita, P., Dita, S., Dittus, F., Djama, F., Djobava, T., Djuvsland, J. I., do Vale, M. A. B., Dobos, D., Dobre, M., Doglioni, C., Dohmae, T., Dolejsi, J., Dolezal, Z., Dolgoshein, B. A., Donadelli, M., Donati, S., Dondero, P., Donini, J., Dopke, J., Doria, A., Dova, M. T., Doyle, A. T., Drechsler, E., Dris, M., Dubreuil, E., Duchovni, E., Duckeck, G., Ducu, O. A., Duda, D., Dudarev, A., Duflot, L., Duguid, L., Dührssen, M., Dunford, M., Duran Yildiz, H., Düren, M., Durglishvili, A., Duschinger, D., Dyndal, M., Eckardt, C., Ecker, K. M., Edgar, R. C., Edson, W., Edwards, N. C., Ehrenfeld, W., Eifert, T., Eigen, G., Einsweiler, K., Ekelof, T., El Kacimi, M., Ellert, M., Elles, S., Ellinghaus, F., Elliot, A. A., Ellis, N., Elmsheuser, J., Elsing, M., Emeliyanov, D., Enari, Y., Endner, O. C., Endo, M., Erdmann, J., Ereditato, A., Ernis, G., Ernst, J., Ernst, M., Errede, S., Ertel, E., Escalier, M., Esch, H., Escobar, C., Esposito, B., Etienvre, A. I., Etzion, E., Evans, H., Ezhilov, A., Fabbri, L., Facini, G., Fakhrutdinov, R. M., Falciano, S., Falla, R. J., Faltova, J., Fang, Y., Fanti, M., Farbin, A., Farilla, A., Farooque, T., Farrell, S., Farrington, S. M., Farthouat, P., Fassi, F., Fassnacht, P., Fassouliotis, D., Faucci Giannelli, M., Favareto, A., Fayard, L., Federic, P., Fedin, O. L., Fedorko, W., Feigl, S., Feligioni, L., Feng, C., Feng, E. J., Feng, H., Fenyuk, A. B., Feremenga, L., Fernandez Martinez, P., Fernandez Perez, S., Ferrando, J., Ferrari, A., Ferrari, P., Ferrari, R., Ferreira de Lima, D. 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G., Zhu, H., Zhu, J., Zhu, Y., Zhuang, X., Zhukov, K., Zibell, A., Zieminska, D., Zimine, N. I., Zimmermann, C., Zimmermann, S., Zinonos, Z., Zinser, M., Ziolkowski, M., Živković, L., Zobernig, G., Zoccoli, A., zur Nedden, M., Zurzolo, G., and Zwalinski, L.
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- 2022
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197. Mortality after Transplantation for Hepatocellular Carcinoma: A Study from the European Liver Transplant Registry
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Hans-Christian Pommergaard, Andreas Arendtsen Rostved, René Adam, Mauro Salizzoni, Miguel Angel Gómez Bravo, Daniel Cherqui, Paolo De Simone, Pauline Houssel-Debry, Vincenzo Mazzaferro, Olivier Soubrane, Juan Carlos García-Valdecasas, Joan Fabregat Prous, Antonio D. Pinna, John O’Grady, Vincent Karam, Christophe Duvoux, and Lau Caspar Thygesen
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hepatocellular carcinoma ,liver transplantation ,prognosis ,propensity score calibration ,unmeasured confounding ,non-cirrhotic liver ,cirrhosis ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background and Aims: Prognosis after liver transplantation differs between hepatocellular carcinoma (HCC) arising in cirrhotic and non-cirrhotic livers and aetiology is poorly understood. The aim was to investigate differences in mortality after liver transplantation between these patients. Methods: We included patients from the European Liver Transplant Registry transplanted due to HCC from 1990 to November 2016 and compared cirrhotic and non-cirrhotic patients using propensity score (PS) calibration of Cox regression estimates to adjust for unmeasured confounding. Results: We included 22,787 patients, of whom 96.5% had cirrhosis. In the unadjusted analysis, non-cirrhotic patients had an increased risk of overall mortality with a hazard ratio (HR) of 1.37 (95% confidence interval [CI] 1.23–1.52). However, the HR approached unity with increasing adjustment and was 1.11 (95% CI 0.99–1.25) when adjusted for unmeasured confounding. Unadjusted, non-cirrhotic patients had an increased risk of HCC-specific mortality (HR 2.62, 95% CI 2.21–3.12). After adjustment for unmeasured confounding, the risk remained significantly increased (HR 1.62, 95% CI 1.31–2.00). Conclusions: Using PS calibration, we showed that HCC in non-cirrhotic liver has similar overall mortality, but higher HCC-specific mortality. This may be a result of a more aggressive cancer form in the non-cirrhotic liver as higher mortality could not be explained by tumour characteristics or other prognostic variables.
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- 2020
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198. Radioembolization of hepatocarcinoma with 90Y glass microspheres: treatment optimization using the dose-toxicity relationship
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Chiesa, C., Mira, M., Bhoori, S., Bormolini, G., Maccauro, M., Spreafico, C., Cascella, T., Cavallo, A., De Nile, M. C., Mazzaglia, S., Capozza, A., Tagliabue, G., Brusa, A., Marchianò, A., Seregni, E., and Mazzaferro, V.
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- 2020
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199. On the role of skin biopsy in the diagnosis of calcific uremic arteriolopathy: a case-based discussion
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Rotondi, Silverio, De Martini, Natalia, Tartaglione, Lida, Muci, Maria Luisa, Petrozza, Vincenzo, Porta, Natale, Leopizzi, Martina, Proietti, Ilaria, Potenza, Concetta, Skroza, Nevena, and Mazzaferro, Sandro
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- 2020
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200. The Italian data on SARS-CoV-2 infection in transplanted patients support an organ specific immune response in liver recipients
- Author
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Rendina, M, Barone, M, Lillo, C, Trapani, S, Masiero, L, Trerotoli, P, Puoti, F, Lupo, L, Tandoi, F, Agnes, S, Grieco, A, Andorno, E, Marenco, S, Giannini, E, Baccarani, U, Toniutto, P, Carraro, A, Colecchia, A, Cescon, M, Morelli, M, Cillo, U, Burra, P, Angeli, P, Colledan, M, Fagiuoli, S, De Carlis, L, Belli, L, De Simone, P, Carrai, P, Di Benedetto, F, De Maria, N, Ettorre, G, Giannelli, V, Gruttadauria, S, Volpes, R, Corsale, S, Mazzaferro, V, Bhoori, S, Romagnoli, R, Martini, S, Rossi, G, Caccamo, L, Donato, M, Rossi, M, Ginanni Corradini, S, Spada, M, Maggiore, G, Tisone, G, Lenci, I, Vennarecci, G, Tortora, R, Vivarelli, M, Svegliati Baroni, G, Zamboni, F, Mameli, L, Tafuri, S, Simone, S, Gesualdo, L, Cardillo, M, Di Leo, A, Rendina M., Barone M., Lillo C., Trapani S., Masiero L., Trerotoli P., Puoti F., Lupo L. G., Tandoi F., Agnes S., Grieco A., Andorno E., Marenco S., Giannini E. G., Baccarani U., Toniutto P., Carraro A., Colecchia A., Cescon M., Morelli M. C., Cillo U., Burra P., Angeli P., Colledan M., Fagiuoli S., De Carlis L., Belli L., De Simone P., Carrai P., Di Benedetto F., De Maria N., Ettorre G. M., Giannelli V., Gruttadauria S., Volpes R., Corsale S., Mazzaferro V., Bhoori S., Romagnoli R., Martini S., Rossi G., Caccamo L., Donato M. F., Rossi M., Ginanni Corradini S., Spada M., Maggiore G., Tisone G., Lenci I., Vennarecci G., Tortora R., Vivarelli M., Svegliati Baroni G., Zamboni F., Mameli L., Tafuri S., Simone S., Gesualdo L., Cardillo M., Di Leo A., Rendina, M, Barone, M, Lillo, C, Trapani, S, Masiero, L, Trerotoli, P, Puoti, F, Lupo, L, Tandoi, F, Agnes, S, Grieco, A, Andorno, E, Marenco, S, Giannini, E, Baccarani, U, Toniutto, P, Carraro, A, Colecchia, A, Cescon, M, Morelli, M, Cillo, U, Burra, P, Angeli, P, Colledan, M, Fagiuoli, S, De Carlis, L, Belli, L, De Simone, P, Carrai, P, Di Benedetto, F, De Maria, N, Ettorre, G, Giannelli, V, Gruttadauria, S, Volpes, R, Corsale, S, Mazzaferro, V, Bhoori, S, Romagnoli, R, Martini, S, Rossi, G, Caccamo, L, Donato, M, Rossi, M, Ginanni Corradini, S, Spada, M, Maggiore, G, Tisone, G, Lenci, I, Vennarecci, G, Tortora, R, Vivarelli, M, Svegliati Baroni, G, Zamboni, F, Mameli, L, Tafuri, S, Simone, S, Gesualdo, L, Cardillo, M, Di Leo, A, Rendina M., Barone M., Lillo C., Trapani S., Masiero L., Trerotoli P., Puoti F., Lupo L. G., Tandoi F., Agnes S., Grieco A., Andorno E., Marenco S., Giannini E. G., Baccarani U., Toniutto P., Carraro A., Colecchia A., Cescon M., Morelli M. C., Cillo U., Burra P., Angeli P., Colledan M., Fagiuoli S., De Carlis L., Belli L., De Simone P., Carrai P., Di Benedetto F., De Maria N., Ettorre G. M., Giannelli V., Gruttadauria S., Volpes R., Corsale S., Mazzaferro V., Bhoori S., Romagnoli R., Martini S., Rossi G., Caccamo L., Donato M. F., Rossi M., Ginanni Corradini S., Spada M., Maggiore G., Tisone G., Lenci I., Vennarecci G., Tortora R., Vivarelli M., Svegliati Baroni G., Zamboni F., Mameli L., Tafuri S., Simone S., Gesualdo L., Cardillo M., and Di Leo A.
- Abstract
Introduction: The study of immune response to SARSCoV-2 infection in different solid organ transplant settings represents an opportunity for clarifying the interplay between SARS-CoV-2 and the immune system. In our nationwide registry study from Italy, we specifically evaluated, during the first wave pandemic, i.e., in non-vaccinated patients, COVID-19 prevalence of infection, mortality, and lethality in liver transplant recipients (LTRs), using non-liver solid transplant recipients (NL-SOTRs) and the Italian general population (GP) as comparators. Methods: Case collection started from February 21 to June 22, 2020, using the data from the National Institute of Health and National Transplant Center, whereas the data analysis was performed on September 30, 2020.To compare the sex- and age-adjusted distribution of infection, mortality, and lethality in LTRs, NL-SOTRs, and Italian GP we applied an indirect standardization method to determine the standardized rate. Results: Among the 43,983 Italian SOTRs with a functioning graft, LTRs accounted for 14,168 patients, of whom 89 were SARS-CoV-2 infected. In the 29,815 NL-SOTRs, 361 cases of SARS-CoV-2 infection were observed. The geographical distribution of the disease was highly variable across the different Italian regions. The standardized rate of infection, mortality, and lethality rates in LTRs resulted lower compared to NL-SOTRs [1.02 (95%CI 0.81-1.23) vs. 2.01 (95%CI 1.8-2.2); 1.0 (95%CI 0.5-1.5) vs. 4.5 (95%CI 3.6-5.3); 1.6 (95%CI 0.7-2.4) vs. 2.8 (95%CI 2.2-3.3), respectively] and comparable to the Italian GP. Discussion: According to the most recent studies on SOTRs and SARS-CoV-2 infection, our data strongly suggest that, in contrast to what was observed in NL-SOTRs receiving a similar immunosuppressive therapy, LTRs have the same risk of SARS-CoV-2 infection, mortality, and lethality observed in the general population. These results suggest an immune response to SARS-CoV-2 infection in LTRS that is different fr
- Published
- 2023
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