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693 results on '"McComb, David W."'

160. Giant Piezomagnetism in Mn3NiN

Author

Boldrin, David, primary, Mihai, Andrei P., additional, Zou, Bin, additional, Zemen, Jan, additional, Thompson, Ryan, additional, Ware, Ecaterina, additional, Neamtu, Bogdan V., additional, Ghivelder, Luis, additional, Esser, Bryan, additional, McComb, David W., additional, Petrov, Peter, additional, and Cohen, Lesley F., additional

Published
2018
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166. Magnetic proximity effect in Pt/CoFe2O4 bilayers

Author

Amamou, Walid, primary, Pinchuk, Igor V., additional, Trout, Amanda H., additional, Williams, Robert E. A., additional, Antolin, Nikolas, additional, Goad, Adam, additional, O’Hara, Dante J., additional, Ahmed, Adam S., additional, Windl, Wolfgang, additional, McComb, David W., additional, and Kawakami, Roland K., additional

Published
2018
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168. Identification and characterization of active and inactive species for surface-enhanced resonance Raman scattering

Author

Khan, Imran, Cunningham, Dale, Graham, Duncan, McComb, David W., and Smith, W. Ewen

Subjects
Nanotechnology -- Research, Silver compounds -- Chemical properties, Raman effect -- Research, Chemicals, plastics and rubber industries
Abstract

A correlated surface-enhanced Raman scattering (SERRS) mapping and transmission electron microscopy (TEM) method is used to study the SERRS activity of a statistically significant number of silver nanoparticles. Particles in various states of aggregation were analyzed to establish relative activities.

Published
2005

189. Fuel efficiency drives the auto industry to reduce vehicle weight

Author

McComb, David W., Lengyel, Jeffrey, Carter, C. Barry, Robinson, Arthur L., Taub, Alan I., and Keoleian, Gregory A.

Abstract

In this age of global warming, the automotive industry is seeking to minimize the energy required to manufacture and operate its products without sacrificing performance and safety or increasing cost. Toward this end, whether cars and trucks are powered by internal-combustion engines or batteries, lowering vehicle weight is a major contributor to reducing energy consumption by increasing fuel efficiency. “The industry is driven by fuel efficiency,” said David Matlock of the Colorado School of Mines, who has helped develop advanced high-strength steels (AHSSs) used in autos.

Published
2019
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196. Chemotherapy drugs derived nanoparticles encapsulating mRNA encoding tumor suppressor proteins to treat triple-negative breast cancer.

Author

Zhang, Chengxiang, Zhang, Xinfu, Zhao, Weiyu, Zeng, Chunxi, Li, Wenqing, Li, Bin, Luo, Xiao, Li, Junan, Jiang, Justin, Deng, Binbin, McComb, David W., and Dong, Yizhou

Abstract

Triple-negative breast cancer (TNBC) is one type of the most aggressive breast cancers with poor prognosis. It is of great urgency to develop new therapeutics for treating TNBC. Based on current treatment guideline and genetic information of TNBC, a combinational therapy platform integrating chemotherapy drugs and mRNA encoding tumor suppressor proteins may become an efficacious strategy. In this study, we developed paclitaxel amino lipid (PAL) derived nanoparticles (NPs) to incorporate both chemotherapy drugs and P53 mRNA. The PAL P53 mRNA NPs showed superior properties compared to Abraxane® and Lipusu® used in the clinic including high paclitaxel loading capacity (24 wt.%, calculated by paclitaxel in PAL), PAL encapsulation efficiency (94.7% ± 6.8%) and mRNA encapsulation efficiency (88.7% ± 0.7%). Meanwhile, these NPs displayed synergetic cytotoxicity of paclitaxel and P53 mRNA in cultured TNBC cells. More importantly, we demonstrated in vivo anti-tumor efficacy of PAL P53 mRNA NPs in an orthotopic TNBC mouse model. Overall, these chemotherapy drugs derived mRNA NPs provide a new platform to integrate chemotherapy and personalized medicine using tumor genetic information, and therefore represent a promising approach for TNBC treatment. [ABSTRACT FROM AUTHOR]

Published
2019
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198. Electron Microscopy Reveals Structural and Chemical Changes at the Nanometer Scale in the Osteogenesis Imperfecta MurinePathology

Author

Kłosowski, Michał M., Carzaniga, Raffaella, Abellan, Patricia, Ramasse, Quentin, McComb, David W., Porter, Alexandra E., and Shefelbine, Sandra J.

Abstract

Alternations of collagen and mineral at the molecular level may have a significant impact on the strength and toughness of bone. In this study, scanning transmission electron microscopy (STEM) and electron energy-loss spectroscopy (EELS) were employed to study structural and compositional changes in bone pathology at nanometer spatial resolution. Tail tendon and femoral bone of osteogenesis imperfecta murine(oim, brittle bone disease) and wild type (WT) mice were compared to reveal defects in the architecture and chemistry of the collagen and collagen-mineral composite in the oimtissue at the molecular level. There were marked differences in the substructure and organization of the collagen fibrils in the oimtail tendon; some regions have clear fibril banding and organization, while in other regions fibrils are disorganized. Malformed collagen fibrils were loosely packed, often bent and devoid of banding pattern. In bone, differences were detected in the chemical composition of mineral in oimand WT. While mineral present in WT and oimbone exhibited the major characteristics of apatite, examination in EELS of the fine structure of the carbon K ionization edge revealed a significant variation in the presence of carbonate in different regions of bone. Variations have been also observed in the fine structure and peak intensities of the nitrogen K-edge. These alterations are suggestive of differences in the maturation of collagen nucleation sites or cross-links. Future studies will aim to establish the scale and impact of the modifications observed in oimtissues. The compositional and structural alterations at the molecular level cause deficiencies at larger length scales. Understanding the effect of molecular alterations to pathologic bone is critical to the design of effective therapeutics.

Published
2024
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199. Tilting and Distortion in the Multiferroic Aurivillius Phase Bi6Ti3Fe1.5Mn0.5O18

Author

Colfer, Louise, Bagués, Núria, Noor-A-Alam, Mohammad, Schmidt, Michael, Nolan, Michael, McComb, David W., and Keeney, Lynette

Abstract

Aurivillius structured Bi6Ti3Fe1.5Mn0.5O18(B6TFMO) has emerged as a rare room temperature multiferroic, exhibiting reversible magnetoelectric switching of ferroelectric domains under cycled magnetic fields. This layered oxide presents exceptional avenues for advancing data storage technologies owing to its distinctive ferroelectric and ferrimagnetic characteristics. Despite its immense potential, a comprehensive understanding of the underlying mechanisms driving multiferroic behavior remains elusive. Herein, we employ atomic resolution electron microscopy to elucidate the interplay of octahedral tilting and atomic-level structural distortions within B6TFMO, associating these phenomena with functional properties. Fundamental electronic features at varying bonding environments within this complex system are scrutinized using electron energy loss spectroscopy (EELS), revealing that the electronic nature of the Ti4+cations within perovskite BO6octahedra is influenced by position within the Aurivillius structure. Layer-by-layer EELS analysis shows an ascending crystal field splitting (Δ) trend from outer to center perovskite layers, with an average increase in Δ of 0.13 ± 0.06 eV. Density functional theory calculations, supported by atomic resolution polarization vector mapping of B-site cations, underscore the correlation between the evolving nature of Ti4+cations, the extent of tetragonal distortion and ferroelectric behavior. Integrated differential phase contrast imaging unveils the position of light oxygen atoms in B6TFMO for the first time, exposing an escalating degree of octahedral tilting toward the center layers, which competes with the magnitude of BO6tetragonal distortion. The observed octahedral tilting, influenced by B-site cation arrangement, is deemed crucial for juxtaposing magnetic cations and establishing long-range ferrimagnetic order in multiferroic B6TFMO.

Published
2024
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200. Engineering LNPs with polysarcosine lipids for mRNA delivery

Author

Kang, Diana D., Hou, Xucheng, Wang, Leiming, Xue, Yonger, Li, Haoyuan, Zhong, Yichen, Wang, Siyu, Deng, Binbin, McComb, David W., and Dong, Yizhou

Abstract

Since the approval of the lipid nanoparticles (LNP)-mRNA vaccines against the SARS-CoV-2 virus, there has been an increased interest in the delivery of mRNA through LNPs. However, current LNP formulations contain PEG lipids, which can stimulate the generation of anti-PEG antibodies. The presence of these antibodies can potentially cause adverse reactions and reduce therapeutic efficacy after administration. Given the widespread deployment of the COVID-19 vaccines, the increased exposure to PEG may necessitate the evaluation of alternative LNP formulations without PEG components. In this study, we investigated a series of polysarcosine (pSar) lipids as alternatives to the PEG lipids to determine whether pSar lipids could still provide the functionality of the PEG lipids in the ALC-0315 and SM-102 LNP systems. We found that complete replacement of the PEG lipid with a pSar lipid can increase or maintain mRNA delivery efficiency and exhibit similar safety profiles in vivo.

Published
2024
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