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164. Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study

Author

Hippisley-Cox, J, Coupland, CAC, Mehta, N, Keogh, RH, Diaz-Ordaz, K, Khunti, K, Lyons, RA, Kee, F, Sheikh, A, Rahman, S, Valabhji, J, Harrison, EM, Sellen, P, Haq, N, Semple, MG, Johnson, PWM, Hayward, A, Nguyen-Van-Tam, JS, Hippisley-Cox, J, Coupland, CAC, Mehta, N, Keogh, RH, Diaz-Ordaz, K, Khunti, K, Lyons, RA, Kee, F, Sheikh, A, Rahman, S, Valabhji, J, Harrison, EM, Sellen, P, Haq, N, Semple, MG, Johnson, PWM, Hayward, A, and Nguyen-Van-Tam, JS

Abstract

OBJECTIVES: To derive and validate risk prediction algorithms to estimate the risk of covid-19 related mortality and hospital admission in UK adults after one or two doses of covid-19 vaccination. DESIGN: Prospective, population based cohort study using the QResearch database linked to data on covid-19 vaccination, SARS-CoV-2 results, hospital admissions, systemic anticancer treatment, radiotherapy, and the national death and cancer registries. SETTINGS: Adults aged 19-100 years with one or two doses of covid-19 vaccination between 8 December 2020 and 15 June 2021. MAIN OUTCOME MEASURES: Primary outcome was covid-19 related death. Secondary outcome was covid-19 related hospital admission. Outcomes were assessed from 14 days after each vaccination dose. Models were fitted in the derivation cohort to derive risk equations using a range of predictor variables. Performance was evaluated in a separate validation cohort of general practices. RESULTS: Of 6 952 440 vaccinated patients in the derivation cohort, 5 150 310 (74.1%) had two vaccine doses. Of 2031 covid-19 deaths and 1929 covid-19 hospital admissions, 81 deaths (4.0%) and 71 admissions (3.7%) occurred 14 days or more after the second vaccine dose. The risk algorithms included age, sex, ethnic origin, deprivation, body mass index, a range of comorbidities, and SARS-CoV-2 infection rate. Incidence of covid-19 mortality increased with age and deprivation, male sex, and Indian and Pakistani ethnic origin. Cause specific hazard ratios were highest for patients with Down's syndrome (12.7-fold increase), kidney transplantation (8.1-fold), sickle cell disease (7.7-fold), care home residency (4.1-fold), chemotherapy (4.3-fold), HIV/AIDS (3.3-fold), liver cirrhosis (3.0-fold), neurological conditions (2.6-fold), recent bone marrow transplantation or a solid organ transplantation ever (2.5-fold), dementia (2.2-fold), and Parkinson's disease (2.2-fold). Other conditions with increased risk (ranging from 1.2-fold to 2.0-fold

Published
2021

170. Case Reports

Author

Shah, Ira, De Carolis, Maria Pia, Salvi, Silvia, Bersani, Iliana, De Carolis, Sara, Sanklecha, M., Mehta, N., Bagban, H., Rajeswari, Binitha, Ninan, Anu, Prasannakumari, Sindhu Nair, and Parukuttyamma, Kusumakumary

Published
2012
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171. Correspondence

Author

Sanklecha, M., Balani, K., Lawrence, Rose Mary, Chandrasekhar, G., Kapil, Umesh, Sachdev, H. P. S., Linga, Vijay Gandhi, Digumati, Raghunadharao, Poddar, Banani, Krishnamurthy, Sriram, Srinivasan, Sadagopan, Sankelecha, Mukesh Uttamchand, Mehta, N., Paul, Yash, and Vashishtha, Vipin M.

Published
2012
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186. Vedolizumab versus Adalimumab for Moderate-to-Severe Ulcerative Colitis

Author

Sands BE1, Peyrin-Biroulet L1, Loftus EV Jr1, Danese S1, Colombel JF1, Törüner M1, Jonaitis L1, Abhyankar B1, Chen J1, Rogers R1, Lirio RA1, Bornstein JD1, Schreiber S1, Calvo S, Gimenez E, Resk JH, Tron EP, Al-Ansari M, Andrews J, Bampton P, Debinski H, Hendy P, Holtmann G, Leong R, Moore G, Hindryckx P, Barac T, Draganova R, Kotzev I, Marinova I, Markov M, Mihaylov Y, Pavlov D, Penkova M, Petrov A, Spassova Z, Stoyanova D, Velev E, Vladimirov B, Yanev F, Axler J, Fedorak R, Fowler S Jr, Halder S, Jairath V, Ponich T, Wong K, Baez E, Ricardo J, Velasquez M, Banic M, Bogadi I, Borzan V, Zgrablic JC, Duvnjak M, Gusej M, Krznaric Z, Cechova I, Hala T, Janu L, Kohout P, Lukas M, Machkova M, Matous J, Ulbrych J, Vanasek T, Klinge L, Rannem T, Theede K, Borissova J, Kull K, Amil M, Bouhnik Y, Gilleta C, Fumery M, Grimaud JC, Hebuterne X, Laharie D, Moreau J, Peyrin-Biroulet L, Roblin X, Baumgart D, Buening C, Dinter J, Gauss A, Kuehbacher T, Fareed Rahman K, Schiefke I, Schreiber S, Von Amim U, Zeuzem S, Leung WK, Kin Kong Li M, Altorjay I, Bene L, Lakatos P, Molnar T, Salamon A, Schnabel R, Tulassay Z, Avni Y, Barkay O, Fishman S, Goldin E, Keret D, Lahat-Zok A, Melzer E, Naftali T, Nimer A, Ovadia B, Zittan E, Andriulli A, Cappello M, Castiglione F, Danese S, Fries W, Gionchetti P, Kohn A, Maconi G, Santino M, Savarino E, Privitera A, Romano M, Vecchi M, Villa E, Cheon JH, Han DS, Jang BI, Jeen YT, Kim JS, Kim SK, Kim HJ, Kim Y, Lee KM, Lee BI, Park DI, Park YS, Song GA, Ye BD, Pokrotnieks J, Tolmanis I, Denapiene G, Kancauskas A, Jakovlevaite V, Jonaitis L, Cruz Palacios A, Larriva de Los Reyes E, Asela Lujano Nicolas L, Mendoza Fuerte E, D'Haens G, Pierik M, Van Der Woude J, Adrych K, Danilkiewicz WC, Gawdis-Wojnarska B, Hartleb M, Karczewski M, Kierkus J, Malecka-Panas E, Petryka R, Piotrowski W, Regula J, Romatowski J, Rozciecha J, Rydzewska G, Smolinski P, Walczak P, Walczak M, Wozniak-Stolarska B, Cotter J, Lopes L, Portela F, Rodrigues Carvalho J, Simona Gheorghe L, Goldis AE, Mateescu RB, Abdulkhakov R, Agafyina A, Alexeeva O, Alikhanov B, Bunkova E, Dvorkin M, Gubonina I, Kashnikov V, Livzan M, Osipenko M, Parfenov A, Pershko A, Pesegova M, Rafalskiy V, Reshetko O, Simanenkov V, Tsybulko S, Valuyskikh E, Yakovlev A, Cvetkovic M, Damjanov D, Djuranovic S, Dugalic P, Nagorni A, Svorcan P, Zdravkovic Petrovic N, Bunganic I, Gregus M, Hlavaty T, Horvath F, Domenech Morral E, Jover Martinez R, Mendoza MIV, Shieh MJ, Wei CC, Altintas E, Atug O, Gonen C, Hamzaoglu H, Hulagu S, Toruner M, Chopey I, Danyliuk S, Datsenko O, Golovchenko N, Golovchenko O, Hospodarskyy I, Ivanov V, Klymenko V, Levchenko O, Lizogub V, Mostovoy Y, Oliinyk O, Polianskyi I, Pyrohovskyi V, Shevchuk S, Ursol G, Vdovychenko V, Vyshyvanyuk V, Beales I, Brookes M, Nwokolo C, Winter J, Aggarwal A, Aguilar H, Alnoah Z, Arce-Nunez E, Arimie C, Arterburn J, Baum C, Bellaguarda E, Bock B, Boone T, Callahan N, Chapman J, Chen S, Chiorean M, Coates A, Connor M, Dellon S, Dryden G, Du Vall G, Flores L, Fogel R, Frias J, Ginsburg P, Greenberg E, Grunkemeier D, Hellstern P, Herfarth H, Hoffman B, Horst S, Idarraga S, Iskandar H, Jain R, Jenkins E, Kaufman B, Khaleq A, Khan A, Khurana S, Lake J, Leavitt J, Leman B, Lewis D, Lindenberg D, Loftus EV, Korman L, Martin J, McCullough M, McNair A, Mehta N, Mutlu E, Narayen V, Paoli-Bruno J, Perez N, Phillips R, Raijman I, Ramirez-Vega R, Randall C, Rinesmith S, Ritter T, Safdi A, Saltzman M, Sands B, Seminerio J, Schulman M, Sedghi S, Shafran I, Shankar M, Silvers D, Soloman N, Tatum H, Tepper R, Tiongco F, Valdes M, Weber J, Zhang C., Sands, Be1, Peyrin-Biroulet, L1, Loftus EV, Jr1, Danese, S1, Colombel, Jf1, Törüner, M1, Jonaitis, L1, Abhyankar, B1, Chen, J1, Rogers, R1, Lirio, Ra1, Bornstein, Jd1, Schreiber, S1, Calvo, S, Gimenez, E, Resk, Jh, Tron, Ep, Al-Ansari, M, Andrews, J, Bampton, P, Debinski, H, Hendy, P, Holtmann, G, Leong, R, Moore, G, Hindryckx, P, Barac, T, Draganova, R, Kotzev, I, Marinova, I, Markov, M, Mihaylov, Y, Pavlov, D, Penkova, M, Petrov, A, Spassova, Z, Stoyanova, D, Velev, E, Vladimirov, B, Yanev, F, Axler, J, Fedorak, R, Fowler, S Jr, Halder, S, Jairath, V, Ponich, T, Wong, K, Baez, E, Ricardo, J, Velasquez, M, Banic, M, Bogadi, I, Borzan, V, Zgrablic, Jc, Duvnjak, M, Gusej, M, Krznaric, Z, Cechova, I, Hala, T, Janu, L, Kohout, P, Lukas, M, Machkova, M, Matous, J, Ulbrych, J, Vanasek, T, Klinge, L, Rannem, T, Theede, K, Borissova, J, Kull, K, Amil, M, Bouhnik, Y, Gilleta, C, Fumery, M, Grimaud, Jc, Hebuterne, X, Laharie, D, Moreau, J, Peyrin-Biroulet, L, Roblin, X, Baumgart, D, Buening, C, Dinter, J, Gauss, A, Kuehbacher, T, Fareed Rahman, K, Schiefke, I, Schreiber, S, Von Amim, U, Zeuzem, S, Leung, Wk, Kin Kong Li, M, Altorjay, I, Bene, L, Lakatos, P, Molnar, T, Salamon, A, Schnabel, R, Tulassay, Z, Avni, Y, Barkay, O, Fishman, S, Goldin, E, Keret, D, Lahat-Zok, A, Melzer, E, Naftali, T, Nimer, A, Ovadia, B, Zittan, E, Andriulli, A, Cappello, M, Castiglione, F, Danese, S, Fries, W, Gionchetti, P, Kohn, A, Maconi, G, Santino, M, Savarino, E, Privitera, A, Romano, M, Vecchi, M, Villa, E, Cheon, Jh, Han, D, Jang, Bi, Jeen, Yt, Kim, J, Kim, Sk, Kim, Hj, Kim, Y, Lee, Km, Lee, Bi, Park, Di, Park, Y, Song, Ga, Ye, Bd, Pokrotnieks, J, Tolmanis, I, Denapiene, G, Kancauskas, A, Jakovlevaite, V, Jonaitis, L, Cruz Palacios, A, Larriva de Los Reyes, E, Asela Lujano Nicolas, L, Mendoza Fuerte, E, D'Haens, G, Pierik, M, Van Der Woude, J, Adrych, K, Danilkiewicz, Wc, Gawdis-Wojnarska, B, Hartleb, M, Karczewski, M, Kierkus, J, Malecka-Panas, E, Petryka, R, Piotrowski, W, Regula, J, Romatowski, J, Rozciecha, J, Rydzewska, G, Smolinski, P, Walczak, P, Walczak, M, Wozniak-Stolarska, B, Cotter, J, Lopes, L, Portela, F, Rodrigues Carvalho, J, Simona Gheorghe, L, Goldis, Ae, Mateescu, Rb, Abdulkhakov, R, Agafyina, A, Alexeeva, O, Alikhanov, B, Bunkova, E, Dvorkin, M, Gubonina, I, Kashnikov, V, Livzan, M, Osipenko, M, Parfenov, A, Pershko, A, Pesegova, M, Rafalskiy, V, Reshetko, O, Simanenkov, V, Tsybulko, S, Valuyskikh, E, Yakovlev, A, Cvetkovic, M, Damjanov, D, Djuranovic, S, Dugalic, P, Nagorni, A, Svorcan, P, Zdravkovic Petrovic, N, Bunganic, I, Gregus, M, Hlavaty, T, Horvath, F, Domenech Morral, E, Jover Martinez, R, Mendoza, Miv, Shieh, Mj, Wei, Cc, Altintas, E, Atug, O, Gonen, C, Hamzaoglu, H, Hulagu, S, Toruner, M, Chopey, I, Danyliuk, S, Datsenko, O, Golovchenko, N, Golovchenko, O, Hospodarskyy, I, Ivanov, V, Klymenko, V, Levchenko, O, Lizogub, V, Mostovoy, Y, Oliinyk, O, Polianskyi, I, Pyrohovskyi, V, Shevchuk, S, Ursol, G, Vdovychenko, V, Vyshyvanyuk, V, Beales, I, Brookes, M, Nwokolo, C, Winter, J, Aggarwal, A, Aguilar, H, Alnoah, Z, Arce-Nunez, E, Arimie, C, Arterburn, J, Baum, C, Bellaguarda, E, Bock, B, Boone, T, Callahan, N, Chapman, J, Chen, S, Chiorean, M, Coates, A, Connor, M, Dellon, S, Dryden, G, Du Vall, G, Flores, L, Fogel, R, Frias, J, Ginsburg, P, Greenberg, E, Grunkemeier, D, Hellstern, P, Herfarth, H, Hoffman, B, Horst, S, Idarraga, S, Iskandar, H, Jain, R, Jenkins, E, Kaufman, B, Khaleq, A, Khan, A, Khurana, S, Lake, J, Leavitt, J, Leman, B, Lewis, D, Lindenberg, D, Loftus, Ev, Korman, L, Martin, J, Mccullough, M, Mcnair, A, Mehta, N, Mutlu, E, Narayen, V, Paoli-Bruno, J, Perez, N, Phillips, R, Raijman, I, Ramirez-Vega, R, Randall, C, Rinesmith, S, Ritter, T, Safdi, A, Saltzman, M, Sands, B, Seminerio, J, Schulman, M, Sedghi, S, Shafran, I, Shankar, M, Silvers, D, Soloman, N, Tatum, H, Tepper, R, Tiongco, F, Valdes, M, Weber, J, and Zhang, C.

Published
2019

194. Demonstration of high-energy 2[omega] (526.5 nm) operation on the National Ignition Facility Laser System

Author

Heestand, G. M., Haynam, C. A., Wegner, P. J., Bowers, M. W., Dixit, S. N., Erbert, G. V., Henesian, M. A., Hermann, M. R., Jancaitis, K. S., Knittel, K., Kohut, T., Lindl, J. D., Manes, K. R., Marshall, C. D., Mehta, N. C., Menapace, J., Moses, E., Murray, J. R., Nostrand, M. C., Orth, C. D., Patterson, R., Sacks, R. A., Saunders, R., Shaw, M. J., Spaeth, M., Sutton, S. B., Williams, W. H., Widmayer, C. C., White, R. K., Whitman, P. K., Yang, S. T., and Van Wonterghem, B. M.

Subjects
Laser beams -- Properties, Frequency converters -- Research, Astronomy, Physics
Abstract

A single beamline of the National Ignition Facility (NIF) has been operated at a wavelength of 526.5 nm (2[omega]) by frequency converting the fundamental 1053 nm (l[omega]) wavelength with an 18.2 mm thick type-I potassium dihydrogen phosphate (KDP) second-harmonic generator (SHG) crystal. Second-harmonic energies of up to 17.9 kJ were measured at the final optics focal plane with a conversion efficiency of 82%. For a similarly configured 192-beam NIF, this scales to a total 2w energy of 3.4 MJ full NIF equivalent (FNE). OCIS codes: 140.0140, 140.3070, 140.3515, 140.3530.

Published
2008

199. Coronary Artery Calcification in Pre-Atrial Fibrillation Ablation Scans: A Missed Opportunity?

Author

Harmon, E, Allam, S, Kutinsky, I, Villines, T, and Mehta, N

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Atrial fibrillation, medicine.disease, Ablation, Internal medicine, Coronary artery calcification, medicine, Cardiology, Cardiology and Cardiovascular Medicine, Missed opportunity, business, Letter To Editor
Published
2020

200. Liver transplantation outcomes after transarterial chemotherapy for hepatocellular carcinoma

Author

Wallace, D, Cowling, TE, Walker, K, Suddle, A, Gimson, A, Rowe, I, Callaghan, C, Sapisochin, G, Mehta, N, Heaton, N, and van der Meulen, J

Abstract

BACKGROUND: Transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) awaiting liver transplantation is widespread, although evidence that it improves outcomes is lacking and there exist concerns about morbidity. The impact of TACE on outcomes after transplantation was evaluated in this study. METHODS: Patients with HCC who had liver transplantation in the UK were identified, and stratified according to whether they received TACE between 2006 and 2016. Cox regression methods were used to estimate hazard ratios (HRs) for death and graft failure after transplantation adjusted for donor and recipient characteristics. RESULTS: In total, 385 of 968 patients (39·8 per cent) received TACE. Five-year patient survival after transplantation was similar in those who had or had not received TACE: 75·2 (95 per cent c.i. 68·8 to 80·5) and 75·0 (70·5 to 78·8) per cent respectively. After adjustment for donor and recipient characteristics, there were no differences in mortality (HR 0·96, 95 per cent c.i. 0·67 to 1·38; P = 0·821) or graft failure (HR 1·01, 0·73 to 1·40; P = 0·964). The number of TACE treatments (2 or more versus 1: HR 0·97, 0·61 to 1·55; P = 0·903) or the time of death after transplantation (within or after 90 days; P = 0·291) did not alter the outcome. The incidence of hepatic artery thrombosis was low in those who had or had not received TACE (1·3 and 2·4 per cent respectively; P = 0·235). CONCLUSION: TACE delivered to patients with HCC before liver transplant did not affect complications, patient death or graft failure after transplantation.

Published
2020

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