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154. Role of tissue factor in embryonic blood vessel development

Author

Carmeliet, Peter, Mackman, Nigel, Moons, Lieve, Luther, Thomas, Gressens, Pierre, Vlaederen, Ilse Van, Demunck, Hilde, Kasper, Michael, Breier, Georg, Evrard, Philippe, Muller, Martin, Risau, Werner, Edgington, Thomas, and Collen, Desire

Published
1996

156. Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System

Author

Bollaerts, Ilse, Van houcke, Jessie, Andries, Lien, De Groef, Lies, and Moons, Lieve

Subjects
Article Subject
Abstract

Damage to the central nervous system (CNS) is one of the leading causes of morbidity and mortality in elderly, as repair after lesions or neurodegenerative disease usually fails because of the limited capacity of CNS regeneration. The causes underlying this limited regenerative potential are multifactorial, but one critical aspect is neuroinflammation. Although classically considered as harmful, it is now becoming increasingly clear that inflammation can also promote regeneration, if the appropriate context is provided. Here, we review the current knowledge on how acute inflammation is intertwined with axonal regeneration, an important component of CNS repair. After optic nerve or spinal cord injury, inflammatory stimulation and/or modification greatly improve the regenerative outcome in rodents. Moreover, the hypothesis of a beneficial role of inflammation is further supported by evidence from adult zebrafish, which possess the remarkable capability to repair CNS lesions and even restore functionality. Lastly, we shed light on the impact of aging processes on the regenerative capacity in the CNS of mammals and zebrafish. As aging not only affects the CNS, but also the immune system, the regeneration potential is expected to further decline in aged individuals, an element that should definitely be considered in the search for novel therapeutic strategies.

Published
2017
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157. Neuroinflammation and Optic Nerve Regeneration: Where Do We Stand in Elucidating Underlying Cellular and Molecular Players?

Author

Andries, Lien, De Groef, Lies, and Moons, Lieve

Subjects
NERVOUS system regeneration, OPTIC nerve, INFLAMMATION, CENTRAL nervous system diseases, CELLULAR control mechanisms
Abstract

Neurodegenerative diseases and central nervous system (CNS) trauma are highly irreversible, in part because adult mammals lack a robust regenerative capacity. A multifactorial problem underlies the limited axonal regeneration potential. Strikingly, neuroinflammation seems able to induce axonal regrowth in the adult mammalian CNS. It is increasingly clear that both blood-borne and resident inflammatory cells as well as reactivated glial cells affect axonal regeneration. The scope of this review is to give a comprehensive overview of the knowledge that links inflammation (with a focus on the innate immune system) to axonal regeneration and to critically reflect on the controversy that still prevails about the cells, molecules and pathways that are dominating the scene. Also, a brief overview is given of what is already known about the crosstalk between and the heterogeneity of cell types that might play a role in axonal regeneration. Recent research indicates that inflammation-induced axonal regrowth is not solely driven by a single-cell population but probably relies on the crosstalk between multiple cell types and the strong regulation of these cell populations in time and space. Moreover, there is growing evidence that the different cell populations are highly heterogeneous and as such can react differently upon injury. This could explain the controversial results that have been obtained over the past years. The primary focus of this manuscript is the retinofugal system of adult mammals, however, when relevant, insights or examples of the spontaneous regenerating zebrafish model and spinal cord research are added. [ABSTRACT FROM AUTHOR]

Published
2020
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166. Genetic specification of left–right asymmetry in the diaphragm muscles and their motor innervation

Author

Charoy, Camille, primary, Dinvaut, Sarah, additional, Chaix, Yohan, additional, Morlé, Laurette, additional, Sanyas, Isabelle, additional, Bozon, Muriel, additional, Kindbeiter, Karine, additional, Durand, Bénédicte, additional, Skidmore, Jennifer M, additional, De Groef, Lies, additional, Seki, Motoaki, additional, Moons, Lieve, additional, Ruhrberg, Christiana, additional, Martin, James F, additional, Martin, Donna M, additional, Falk, Julien, additional, and Castellani, Valerie, additional

Published
2017
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172. The role of fatty acid β-oxidation in lymphangiogenesis

Author

Wong, Brian W., primary, Wang, Xingwu, additional, Zecchin, Annalisa, additional, Thienpont, Bernard, additional, Cornelissen, Ivo, additional, Kalucka, Joanna, additional, García-Caballero, Melissa, additional, Missiaen, Rindert, additional, Huang, Hongling, additional, Brüning, Ulrike, additional, Blacher, Silvia, additional, Vinckier, Stefan, additional, Goveia, Jermaine, additional, Knobloch, Marlen, additional, Zhao, Hui, additional, Dierkes, Cathrin, additional, Shi, Chenyan, additional, Hägerling, René, additional, Moral-Dardé, Veronica, additional, Wyns, Sabine, additional, Lippens, Martin, additional, Jessberger, Sebastian, additional, Fendt, Sarah-Maria, additional, Luttun, Aernout, additional, Noel, Agnès, additional, Kiefer, Friedemann, additional, Ghesquière, Bart, additional, Moons, Lieve, additional, Schoonjans, Luc, additional, Dewerchin, Mieke, additional, Eelen, Guy, additional, Lambrechts, Diether, additional, and Carmeliet, Peter, additional

Published
2016
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173. Potent and selective antisense oligonucleotides targeting the transforming growth factor beta (TGF-β) isoforms in advanced glaucoma: a preclinical evaluation

Author

Hasenbach, Kathy, primary, Van Bergen, Tine, additional, Vandewalle, Evelien, additional, De Groef, Lies, additional, Van Hove, Inge, additional, Moons, Lieve, additional, Stalmans, Ingeborg, additional, Fettes, Petra, additional, Leo, Eugen, additional, Wosikowski, Katja, additional, and Janicot, Michel, additional

Published
2016
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175. Author response: Genetic specification of left–right asymmetry in the diaphragm muscles and their motor innervation

Author

Charoy, Camille, primary, Dinvaut, Sarah, additional, Chaix, Yohan, additional, Morlé, Laurette, additional, Sanyas, Isabelle, additional, Bozon, Muriel, additional, Kindbeiter, Karine, additional, Durand, Bénédicte, additional, Skidmore, Jennifer M, additional, De Groef, Lies, additional, Seki, Motoaki, additional, Moons, Lieve, additional, Ruhrberg, Christiana, additional, Martin, James F, additional, Martin, Donna M, additional, Falk, Julien, additional, and Castellani, Valerie, additional

Published
2016
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176. Aberrant Collagen Composition of the Trabecular Meshwork Results in Reduced Aqueous Humor Drainage and Elevated IOP in MMP-9 Null Mice

Author

De Groef, Lies, primary, Andries, Lien, additional, Siwakoti, Anuja, additional, Geeraerts, Emiel, additional, Bollaerts, Ilse, additional, Noterdaeme, Lut, additional, Etienne, Isabelle, additional, Papageorgiou, Anna-Pia, additional, Stalmans, Ingeborg, additional, Billen, Johan, additional, West-Mays, Judith A., additional, and Moons, Lieve, additional

Published
2016
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178. A proteomic approach to understand MMP?3?driven developmental processes in the postnatal cerebellum: Chaperonin CCT6A and MAP kinase as contributing factors

Author

Van Hove, Ingrid, Verslegers, Mieke, Hu, Tjing-Tjing, Carden, Martin J., Arckens, Lutgarde, and Moons, Lieve

Subjects
RC0321, QP506
Abstract

Matrix metalloproteinase?3 (MMP?3) deficiency in mice was previously reported to result in a transiently retarded granule cell migration at postnatal day 8 (P8) and a sustained disturbed arborization of Purkinje cell dendrites from P8 on, concomitant with a delayed synapse formation between granule cells and Purkinje cells and resulting in mild deficits in motor performance in adult animals. However, the molecular mechanisms by which MMP?3 contributes to proper development of the cerebellar cortex during the first postnatal weeks remains unknown. In this study, we used a functional proteomics approach to investigate alterations in protein expression in postnatal cerebella of wild?type versus MMP?3 deficient mice, and to further elucidate MMP?3?dependent pathways and downstream targets in vivo. At P8, two?dimensional difference gel electrophoresis and mass spectrometry identified 20 unique proteins with a different expression between the two genotypes. Subsequent “Ingenuity Pathway Analysis” and Western blotting indicate that the chaperonin containing T?complex polypeptide 1, subunit 6A and the MAP kinase signaling pathway play a key role in the MMP?3?dependent regulation of neurite outgrowth and neuronal migration in the developing brain.

Published
2015

184. Altered neuronal architecture and plasticity in the visual cortex of MMP-3 deficient mice

Author

Aerts, Jeroen, Nys, Julie, Smolders, Katrien, Claes, L, Hu, Tjing, Moons, Lieve, and Arckens, Lut

Subjects
Male, Cerebellum, Histology, genetic structures, Biology, Eye Enucleation, Neurofilament Proteins, Apical dendrite, Cortex (anatomy), Neuroplasticity, medicine, Animals, Visual Cortex, Mice, Knockout, Neuronal Plasticity, Neocortex, Pyramidal Cells, General Neuroscience, Long-term potentiation, Visual cortex, medicine.anatomical_structure, Synaptic plasticity, Matrix Metalloproteinase 3, Sensory Deprivation, Anatomy, Neuroscience, Photic Stimulation
Abstract

Matrix metalloproteinases (MMPs) are Zn(2+)-dependent endopeptidases considered to be essential for normal brain development and neuroplasticity by modulating extracellular matrix proteins, receptors, adhesion molecules, growth factors and cytoskeletal proteins. Specifically, MMP-3 has recently been implicated in synaptic plasticity, hippocampus-dependent learning and neuronal development and migration in the cerebellum. However, the function(s) of this enzyme in the neocortex is understudied. Therefore, we explored the phenotypical characteristics of the neuronal architecture and the capacity for experience-dependent cortical plasticity in the visual cortex of adult MMP-3-deficient (MMP-3(-/-)) mice. Golgi-Cox stainings revealed a significant reduction in apical dendritic length and an increased number of apical obliques for layer V pyramidal neurons in the visual cortex of adult MMP-3(-/-) mice compared to wild-type (WT) animals. In addition, a significant upregulation of both phosphorylated and non-phosphorylated neurofilament protein (NF)-high, phosphorylated NF-medium, NF-low and α-internexin was detected in the visual cortex of MMP-3(-/-) mice. To assess the effect of MMP-3 deficiency on cortical plasticity, we monocularly enucleated adult MMP-3(-/-) mice and analyzed the reactivation of the contralateral visual cortex 7 weeks post-enucleation. In contrast to previous results in C57Bl/6J adult mice, activity remained confined to the binocular zone and did not expand into the monocular regions indicative for an aberrant open-eye potentiation. Permanent hypoactivity in the monocular cortex lateral and medial to V1 also indicated a lack of cross-modal plasticity. These observations demonstrate that genetic inactivation of MMP-3 has profound effects on the structural integrity and plasticity response of the visual cortex of adult mice. ispartof: BRAIN STRUCTURE & FUNCTION vol:220 issue:5 pages:2675-2689 ispartof: location:San Diego, CA, USA status: published

Published
2013

187. Persistent Impact of In utero Irradiation on Mouse Brain Structure and Function Characterized by MR Imaging and Behavioral Analysis

Author

Verreet, Tine, primary, Rangarajan, Janaki Raman, additional, Quintens, Roel, additional, Verslegers, Mieke, additional, Lo, Adrian C., additional, Govaerts, Kristof, additional, Neefs, Mieke, additional, Leysen, Liselotte, additional, Baatout, Sarah, additional, Maes, Frederik, additional, Himmelreich, Uwe, additional, D'Hooge, Rudi, additional, Moons, Lieve, additional, and Benotmane, Mohammed A., additional

Published
2016
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191. Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity

Author

Mastenbroek, Tom G., primary, Feijge, Marion A.H., additional, Kremers, Romy M.W., additional, van den Bosch, Marion T.J., additional, Swieringa, Frauke, additional, De Groef, Lies, additional, Moons, Lieve, additional, Bennett, Cavan, additional, Ghevaert, Cedric, additional, Johnson, Jason L., additional, van der Meijden, Paola E.J., additional, and Cosemans, Judith M.E.M., additional

Published
2015
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195. Serotype-dependent transduction efficiencies of recombinant adeno-associated viral vectors in monkey neocortex

Author

Gerits, Annelies, primary, Vancraeyenest, Pascaline, additional, Vreysen, Samme, additional, Laramée, Marie-Eve, additional, Michiels, Annelies, additional, Gijsbers, Rik, additional, Van den Haute, Chris, additional, Moons, Lieve, additional, Debyser, Zeger, additional, Baekelandt, Veerle, additional, Arckens, Lutgarde, additional, and Vanduffel, Wim, additional

Published
2015
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196. A detailed characterization of congenital defects and mortality following moderate X-ray doses during neurulation.

Author

Craenen, Kai, Verslegers, Mieke, Buset, Jasmine, Baatout, Sarah, Moons, Lieve, and Benotmane, Mohammed Abderrafi

Abstract

Background: Both epidemiological and animal studies have previously indicated a link between in utero radiation exposure and birth defects such as microphthalmos, anophthalmos, and exencephaly. However, detailed knowledge on embryonic radiosensitivity during different stages of neurulation is limited, especially in terms of neural tube defect and eye defect development. Methods: To assess the most radiosensitive stage during neurulation, pregnant C57BL6/J mice were X-irradiated (0.5 Gy or 1.0 Gy) at embryonic days (E)7, E7.5, E8, E8.5, or E9. Next, the fetuses were scored macroscopically for various defects and prenatal resorptions/deaths were counted. In addition, cranial skeletal development was ascertained using the alcian-alizarin method. Furthermore, postnatal/young adult survival was followed until 5 weeks (W5) of age, after X-irradiation at E7.5 (0.1 Gy, 0.5 Gy, or 1.0 Gy). In addition, body and brain weights were registered at adult age (W10) following X-ray exposure at E7.5 (0.1 Gy, 0.5 Gy). Results: Several malformations, including microphthalmos and exencephaly, were most evident after irradiation at E7.5, with significance starting respectively at 0.5 Gy and 1.0 Gy. Prenatal mortality and weight were significantly affected in all irradiated groups. Long-term follow-up of E7.5 irradiated animals revealed a reduction in survival at 5 weeks of age after high dose exposure (1.0 Gy), while lower doses (0.5 Gy, 0.1 Gy) did not affect brain and body weight at postnatal week 10. Conclusions: With this study, we gained more insight in radiosensitivity throughout neurulation, and offered a better defined model to further study radiation-induced malformations and the underlying mechanisms. [ABSTRACT FROM AUTHOR]

Published
2018
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197. Amyloid β Oligomers Disrupt Blood–CSF Barrier Integrity by Activating Matrix Metalloproteinases

Author

Brkic, Marjana, primary, Balusu, Sriram, additional, Van Wonterghem, Elien, additional, Gorlé, Nina, additional, Benilova, Iryna, additional, Kremer, Anna, additional, Van Hove, Inge, additional, Moons, Lieve, additional, De Strooper, Bart, additional, Kanazir, Selma, additional, Libert, Claude, additional, and Vandenbroucke, Roosmarijn E., additional

Published
2015
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