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152. Association between loop diuretic dose changes and outcomes in chronic heart failure: observations from the ESC-EORP Heart Failure Long-Term Registry

Author

Kapelios, C.J. Laroche, C. Crespo-Leiro, M.G. Anker, S.D. Coats, A.J.S. Díaz-Molina, B. Filippatos, G. Lainscak, M. Maggioni, A.P. McDonagh, T. Mebazaa, A. Metra, M. Moura, B. Mullens, W. Piepoli, M.F. Rosano, G.M.C. Ruschitzka, F. Seferovic, P.M. Lund, L.H. Gale, C.P. Beleslin, B. Budaj, A. Chioncel, O. Dagres, N. Danchin, N. Erlinge, D. Emberson, J. Glikson, M. Gray, A. Kayikcioglu, M. Maggioni, A. Nagy, K.V. Nedoshivin, A. Petronio, A.-S. Roos-Hesselink, J. Wallentin, L. Zeymer, U. Anker, S. Mebazaa, A. Coats, A. Filippatos, G. Ferrari, R. Maggioni, A.P. Goda, A. Diez, M. Fernandez, A. Fruhwald, F. Gatzov, P. Kurlianskaya, A. Hullin, R. Christodoulides, T. Hradec, J. Nielsen, O.W. Nedjar, R. Uuetoa, T. Jimenez, J.F.D. Harjola, V.-P. Logeart, D. Tousoulis, D. Milicic, D. Merkely, B. Amir, O. Shotan, A. Shafie, D. Mirrakhimov, E. Kavoliuniene, A. Erglis, A. Otljanska, M. Kostovska, E.S. DeMarco, D.C. Drozdz, J. Fonseca, C. Chioncel, O. Dekleva, M. Dahlstrom, U. Lainscak, M. Goncalvesova, E. Estrago, V. Bajraktari, G. Auer, J. Ablasser, K. Fruhwald, F. Dolze, T. Brandner, K. Gstrein, S. Poelzl, G. Moertl, D. Reiter, S. Muslibegovic, A. Vasilj, M. Fazlibegovic, E. Cesko, M. Zelenika, D. Palic, B. Pravdic, D. Cuk, D. Vitlianova, K. Katova, T. Kurteva, T. Gatzov, P. Kamenova, D. Antova, M. Krejci, J. Spinar, J. Krupicka, J. Malek, F. Hegarova, M. Lazarova, M. Monhart, Z. Hassanein, M. El Messiry, F. El Shazly, A.H. Elrakshy, Y. Youssef, A. Moneim, A.A. Noamany, M. Dayem, T.K.A. Farag, N. Halawa, S.I. Hamid, M.A. Saleh, A. Ebeid, H. Hanna, R. Louis, O. Enen, M.A. Ibrahim, B.S. Nasr, G. Elbahry, A. Sobhy, H. Ashmawy, M. Gouda, M. Aboleineen, W. Bernard, Y. Meneveau, N. Pillot, M. Morel, M. Seronde, M.-F. Schiele, F. Briand, F. Delahaye, F. Damy, T. Eicher, J.-C. de Groote, P. Fertin, M. Lamblin, N. Isnard, R. Thevenin, S. Hagege, A. Logeart, D. Le Marcis, V. Ly, J.-F. Coisne, D. Lequeux, B. Le Moal, V. Mascle, S. Lotton, P. Behar, N. Donal, E. Ridard, C. Reynaud, A. Basquin, A. Bauer, F. Codjia, R. Galinier, M. Tourikis, P. Stavroula, M. Stefanadis, C. Chrysohoou, C. Kotrogiannis, I. Matzaraki, V. Karavidas, A. Tsitsinakis, G. Kapelios, C. Nanas, J. Kampouri, H. Nana, E. Kaldara, E. Eugenidou, A. Vardas, P. Saloustros, I. Tsaknakis, T. Evangelou, S. Tziourganou, H. Tsaroucha, A. Papadopoulou, A. Douras, A. Polgar, L. Kosztin, A. Nyolczas, N. Nagy, A.C. Halmosi, R. Elber, J. Shotan, A. Fuhrmann, A.V. Amir, O. Romano, S. Marcon, S. Penco, M. Di Mauro, M. Lemme, E. Carubelli, V. Rovetta, R. Bulgari, M. Quinzani, F. Bosi, S. Schiavina, G. Squeri, A. Di Tano, G. Pirelli, S. Ferrari, R. Fucili, A. Passero, T. Musio, S. Di Biase, M. Correale, M. Salvemini, G. Brognoli, S. Zanelli, E. Giordano, A. Agostoni, P. Salvioni, E. Copelli, S. Modena, M.G. Valenti, C. Olaru, A. Bandino, S. Deidda, M. Mercuro, G. Marino, P.N. Di Ruocco, M.V. Piccinino, C. Parrinello, G. Licata, G. Torres, D. Giambanco, S. Busalacchi, S. Arrotti, S. Novo, S. Inciardi, R.M. Pieri, P. Galifi, M.A. Teresi, G. Buccheri, D. Minacapelli, A. Veniani, M. Frisinghelli, A. Priori, S.G. Cattaneo, S. Opasich, C. Gualco, A. Pagliaro, M. Mancone, M. Fedele, F. Cinque, A. Vellini, M. Scarfo, I. Romeo, F. Ferraiuolo, F. Sergi, D. Anselmi, M. Melandri, F. Leci, E. Iori, E. Bovolo, V. Frea, S. Bergerone, S. Botta, M. Canavosio, F.G. Gaita, F. Merlo, M. Cinquetti, M. Sinagra, G. Ramani, F. Fabris, E. Artico, J. Miani, D. Fresco, C. Daneluzzi, C. Proclemer, A. Cicoira, M. Zanolla, L. Marchese, G. Torelli, F. Vassanelli, C. Voronina, N. Tamakauskas, V. Smalinskas, V. Karaliute, R. Petraskiene, I. Rumbinaite, E. Kavoliuniene, A. Brazyte-Ramanauskiene, R. Petraskiene, D. Sinkiewicz, W. Gilewski, W. Pietrzak, J. Orzel, T. Kardaszewicz, P. Lazorko-Piega, M. Mosakowska, K. Bellwon, J. Rynkiewicz, A. Raczak, G. Lewicka, E. Dabrowska-Kugacka, A. Bartkowiak, R. Wozakowska-Kaplon, B. Krzeminski, A. Zabojszcz, M. Grzegorzko, A. Bury, K. Nessler, J. Zalewski, J. Furman, A. Poliwczak, A. Bala, A. Zycinski, P. Rudzinska, M. Jankowski, L. Kasprzak, J.D. Michalak, L. Soska, K.W. Drozdz, J. Huziuk, I. Flis, P. Weglarz, J. Bodys, A. Grajek, S. Straburzynska-Migaj, E. Dankowski, R. Szymanowska, K. Szyszka, A. Nowicka, A. Samcik, M. Wolniewicz, L. Komorowska, K. Poprawa, I. Komorowska, E. Sajnaga, D. Zolbach, A. Abdulkarim, A.-F. Lauko-Rachocka, A. Kaminski, L. Kostka, A. Cichy, A. Ruszkowski, P. Splawski, M. Fitas, G. Szymczyk, A. Serwicka, A. Fiega, A. Zysko, D. Krysiak, W. Szabowski, S. Skorek, E. Pruszczyk, P. Bienias, P. Ciurzynski, M. Welnicki, M. Mamcarz, A. Folga, A. Zielinski, T. Rywik, T. Leszek, P. Sobieszczanska-Malek, M. Kozar-Kaminska, K. Komuda, K. Wisniewska, J. Tarnowska, A. Marchel, M. Opolski, G. Kaplon-Cieslicka, A. Gil, R.J. Mozenska, O. Gil, K. Pawlak, A. Michalek, A. Krzesinski, P. Piotrowicz, K. Stanczyk, A. Skrobowski, A. Ponikowski, P. Jankowska, E. Rozentryt, P. Polonski, L. Nowalany-Kozielska, E. Kuczaj, A. Kalarus, Z. Szulik, M. Klys, J. Prokop-Lewicka, G. Kleinrok, A. TavaresAguiar, C. Ventosa, A. Pereira, S. Faria, R. Chin, J. DeJesus, I. Santos, R. Silva, P. Moreno, N. Lourenço, C. Pereira, A. Castro, A. Andrade, A. OliveiraGuimaraes, T. Martins, S. Placido, R. Lima, G. Brito, D. Francisco, A.R. Proenca, M. Araujo, I. Marques, F. Fonseca, C. Moura, B. Campelo, M. Silva-Cardoso, J. Rodrigues, J. Rangel, I. Martins, E. Peres, M. Marta, L. Severino, D. Durao, D. Leao, S. Magalhaes, P. Moreira, I. Ferreira, C. Araujo, C. Ferreira, A. Baptista, A. Radoi, M. Bicescu, G. Vinereanu, D. Sinescu, C.-J. Macarie, C. Popescu, R. Daha, I. Dan, G.-A. Stanescu, C. Dan, A. Craiu, E. Nechita, E. Christodorescu, R. Otasevic, P. Seferovic, P.M. Simeunovic, D. Ristic, A.D. Celic, V. Pavlovic-Kleut, M. Stojcevski, B. Pencic, B. Stevanovic, A. Andric, A. Simić, D. Ašanin, M. Iric-Cupic, V. Jovic, M. Milanov, S. Mitic, V. Atanaskovic, V. Antic, S. Pavlovic, M. Stanojevic, D. Stoickov, V. Ilic, S. DeljaninIlic, M. Petrovic, D. Stojsic, S. Kecojevic, S. Dodic, S. Adic, N.C. Cankovic, M. Stojiljkovic, J. Mihajlovic, B. Radin, A. Radovanovic, S. Krotin, M. Klabnik, A. Pernicky, M. Murin, J. Kovar, F. Kmec, J. Strasek, M. Iskra, M.S. Ravnikar, T. Suligoj, N.C. Fras, Z. Jug, B. Glavic, T. Losic, R. Bombek, M. Krunic, B. Horvat, S. Kovac, D. Rajtman, D. Letonja, M. Winkler, R. Melihen-Bartolic, C. Bartolic, A. Kladnik, M. Pusnik, C.S. Marolt, A. Klen, J. Drnovsek, B. Leskovar, B. Anguita, M.J.F. GallegoPage, J.C. Martinez, F.M.S. Andres, J. Bayes-Genis, A. Mirabet, S. Mendez, A. Garcia-Cosio, L. Leon, V. Gonzalez-Costello, J. Muntane, G. Garay, A. Alcade-Martinez, V. Fernandez, S.L. Rivera-Lopez, R. Fernandez-Alvarez, M. Serrano-Martinez, J.L. Grille-Cancela, Z. Marzoa-Rivas, R. Paniagua-Martin, M.J. Barge-Caballero, E. Gonzalez-Gallarza, R.D. SalvadorMontanes, O. Manjavacas, A.M.I. Conde, A.C. Araujo, A. Soria, T. Gomez-Bueno, M. Cobo-Marcos, M. Alonso-Pulpon, L. SegoviaCubero, J. Sayago, I. Gonzalez-Segovia, A. Briceno, A. Subias, P.E. Cano, M.J.R. Sanchez, M.A.G. Jimenez, J.F.D. Pinilla, J.M.G. de la Villa, B.G. Sahuquillo, A. Marques, R.B. Calvo, F.T. Perez-Martinez, M.T. Garrido-Bravo, I.P. Pastor-Perez, F. Pascual-Figal, D.A. Molina, B.D. Orus, J. Gonzalo, F.E. Bertomeu, V. Valero, R. Martinez-Abellan, R. Quiles, J. Mateo, I. ElAmrani, A. Fernandez-Vivancos, C. Valero, D.B. Almenar-Bonet, L. Sanchez-Lazaro, I.J. Marques-Sule, E. Facila-Rubio, L. Perez-Silvestre, J. Garcia-Gonzalez, P. Garcia-Escriva, D. Pellicer-Cabo, A. de laFuente Galan, L. Diaz, J.L. Platero, A.R. Arias, J.C. Blasco-Peiro, T. Julve, M.S. Sanchez-Insa, E. Portoles-Ocampo, A. Melin, M. Hägglund Lindahl, I.-M. Asserlund, B. Olsson, L. Dahlström, U. Afzelius, M. Karlström, P. Tengvall, L. Olsson, B. Kalayci, S. Cavusoglu, Y. Gencer, E. Yilmaz, M.B. Gunes, H.

Abstract

Aims: Guidelines recommend down-titration of loop diuretics (LD) once euvolaemia is achieved. In outpatients with heart failure (HF), we investigated LD dose changes in daily cardiology practice, agreement with guideline recommendations, predictors of successful LD down-titration and association between dose changes and outcomes. Methods and results: We included 8130 HF patients from the ESC-EORP Heart Failure Long-Term Registry. Among patients who had dose decreased, successful decrease was defined as the decrease not followed by death, HF hospitalization, New York Heart Association class deterioration, or subsequent increase in LD dose. Mean age was 66 ± 13 years, 71% men, 62% HF with reduced ejection fraction, 19% HF with mid-range ejection fraction, 19% HF with preserved ejection fraction. Median [interquartile range (IQR)] LD dose was 40 (25–80) mg. LD dose was increased in 16%, decreased in 8.3% and unchanged in 76%. Median (IQR) follow-up was 372 (363–419) days. Diuretic dose increase (vs. no change) was associated with HF death [hazard ratio (HR) 1.53, 95% confidence interval (CI) 1.12–2.08; P = 0.008] and nominally with cardiovascular death (HR 1.25, 95% CI 0.96–1.63; P = 0.103). Decrease of diuretic dose (vs. no change) was associated with nominally lower HF (HR 0.59, 95% CI 0.33–1.07; P = 0.083) and cardiovascular mortality (HR 0.62,. 95% CI 0.38–1.00; P = 0.052). Among patients who had LD dose decreased, systolic blood pressure [odds ratio (OR) 1.11 per 10 mmHg increase, 95% CI 1.01–1.22; P = 0.032], and absence of (i) sleep apnoea (OR 0.24, 95% CI 0.09–0.69; P = 0.008), (ii) peripheral congestion (OR 0.48, 95% CI 0.29–0.80; P = 0.005), and (iii) moderate/severe mitral regurgitation (OR 0.57, 95% CI 0.37–0.87; P = 0.008) were independently associated with successful decrease. Conclusion: Diuretic dose was unchanged in 76% and decreased in 8.3% of outpatients with chronic HF. LD dose increase was associated with worse outcomes, while the LD dose decrease group showed a trend for better outcomes compared with the no-change group. Higher systolic blood pressure, and absence of (i) sleep apnoea, (ii) peripheral congestion, and (iii) moderate/severe mitral regurgitation were independently associated with successful dose decrease. © 2020 European Society of Cardiology

Published
2020

153. Sex- and age-related differences in the management and outcomes of chronic heart failure: an analysis of patients from the ESC HFA EORP Heart Failure Long-Term Registry

Author

Lainšcak, M. Milinkovic, I. Polovina, M. Crespo-Leiro, M.G. Lund, L.H. Anker, S.D. Laroche, C. Ferrari, R. Coats, A.J.S. McDonagh, T. Filippatos, G. Maggioni, A.P. Piepoli, M.F. Rosano, G.M.C. Ruschitzka, F. Simic, D. Ašanin, M. Eicher, J.-C. Yilmaz, M.B. Seferovic, P.M. Gale, C.P. Chair, G.B. Branko Beleslin, R.S. Andrzej Budaj, P.L. Chioncel, R.O. Nikolaos Dagres, D.E. Nicolas Danchin, F.R. David Erlinge, S.E. Jonathan Emberson, G.B. Michael Glikson, I.L. Alastair Gray, G.B. Meral Kayikcioglu, T.R. Aldo Maggioni, I.T. Klaudia Vivien Nagy, H.U. Aleksandr Nedoshivin, R.U. Anna-Sonia Petronio, I.T. Jolien Roos-Hesselink, N.L. Lars Wallentin, S.E. Uwe Zeymer, D.E. Mebazaa, A. Coats, A. A. Goda, A.L. M. Diez, A.R. A. Fernandez, A.R. F. Fruhwald, A.T. Fazlibegovic, E. P. Gatzov, B.G. A. Kurlianskaya, B.Y. R. Hullin, C.H. T. Christodoulides, C.Y. J. Hradec, C.Z. O. Wendelboe Nielsen, D.K. R. Nedjar, D.Z. T. Uuetoa, E.E. M. Hassanein, E.G. J. F. Delgado Jimenez, E.S. V-P. Harjola, F.I. D. Logeart, F.R. V. Chumburidze, G.E. D. Tousoulis, G.R. D. Milicic, H.R. B. Merkely, H.U. O'Donoghue IE, E. O. Amir, I.L. A. Shotan, I.L. D. Shafie, I.R. M. Metra, I.T. A. Matsumori, J.P. E. Mirrakhimov, K.G. A. Kavoliuniene, L.T. A. Erglis, L.V. Vataman, E. M. Otljanska, M.K. E. Srbinovska Kostovska, M.K. D. Cassar DeMarco, M.T. J. Drozdz, P.L. Fonseca, C. M. Dekleva, R.S. E. Shkolnik, R.U. U. Dahlstrom, S.E. M. Lainscak, S.I. E. Goncalvesova, S.K. A. Temizhan, T.R. V. Estrago, U.Y. G. Bajraktari, X.K. Auer, J. Ablasser, K. Fruhwald, F. Dolze, T. Brandner, K. Gstrein, S. Poelzl, G. Moertl, D. Reiter, S. Podczeck-Schweighofer, A. Muslibegovic, A. Vasilj, M. Cesko, M. Zelenika, D. Palic, B. Pravdic, D. Cuk, D. Vitlianova, K. Katova, T. Velikov, T. Kurteva, T. Gatzov, P. Kamenova, D. Antova, M. Sirakova, V. Krejci, J. Mikolaskova, M. Spinar, J. Krupicka, J. Malek, F. Hegarova, M. Lazarova, M. Monhart, Z. Hassanein, M. Sobhy, M. El Messiry, F. El Shazly, A.H. Elrakshy, Y. Youssef, A. Moneim, A.A. Noamany, M. Reda, A. Dayem, T.K.A. Farag, N. Halawa, S.I. Hamid, M.A. Said, K. Saleh, A. Ebeid, H. Hanna, R. Aziz, R. Louis, O. Enen, M.A. Ibrahim, B.S. Nasr, G. Elbahry, A. Sobhy, H. Ashmawy, M. Gouda, M. Aboleineen, W. Bernard, Y. Luporsi, P. Meneveau, N. Pillot, M. Morel, M. Seronde, M.-F. Schiele, F. Briand, F. Delahaye, F. Damy, T. de Groote, P. Fertin, M. Lamblin, N. Isnard, R. Lefol, C. Thevenin, S. Hagege, A. Jondeau, G. Logeart, D. Le Marcis, V. Ly, J.-F. Coisne, D. Lequeux, B. Le Moal, V. Mascle, S. Lotton, P. Behar, N. Donal, E. Thebault, C. Ridard, C. Reynaud, A. Basquin, A. Bauer, F. Codjia, R. Galinier, M. Tourikis, P. Stavroula, M. Tousoulis, D. Stefanadis, C. Chrysohoou, C. Kotrogiannis, I. Matzaraki, V. Dimitroula, T. Karavidas, A. Tsitsinakis, G. Kapelios, C. Nanas, J. Kampouri, H. Nana, E. Kaldara, E. Eugenidou, A. Vardas, P. Saloustros, I. Patrianakos, A. Tsaknakis, T. Evangelou, S. Nikoloulis, N. Tziourganou, H. Tsaroucha, A. Papadopoulou, A. Douras, A. Polgar, L. Merkely, B. Kosztin, A. Nyolczas, N. Nagy, A.C. Halmosi, R. Elber, J. Alony, I. Shotan, A. Fuhrmann, A.V. Amir, O. Romano, S. Marcon, S. Penco, M. Di Mauro, M. Lemme, E. Carubelli, V. Rovetta, R. Metra, M. Bulgari, M. Quinzani, F. Lombardi, C. Bosi, S. Schiavina, G. Squeri, A. Barbieri, A. Di Tano, G. Pirelli, S. Fucili, A. Passero, T. Musio, S. Di Biase, M. Correale, M. Salvemini, G. Brognoli, S. Zanelli, E. Giordano, A. Agostoni, P. Italiano, G. Salvioni, E. Copelli, S. Modena, M.G. Reggianini, L. Valenti, C. Olaru, A. Bandino, S. Deidda, M. Mercuro, G. Dessalvi, C.C. Marino, P.N. Di Ruocco, M.V. Sartori, C. Piccinino, C. Parrinello, G. Licata, G. Torres, D. Giambanco, S. Busalacchi, S. Arrotti, S. Novo, S. Inciardi, R.M. Pieri, P. Chirco, P.R. Galifi, M.A. Teresi, G. Buccheri, D. Minacapelli, A. Veniani, M. Frisinghelli, A. Priori, S.G. Cattaneo, S. Opasich, C. Gualco, A. Pagliaro, M. Mancone, M. Fedele, F. Cinque, A. Vellini, M. Scarfo, I. Romeo, F. Ferraiuolo, F. Sergi, D. Anselmi, M. Melandri, F. Leci, E. Iori, E. Bovolo, V. Pidello, S. Frea, S. Bergerone, S. Botta, M. Canavosio, F.G. Gaita, F. Merlo, M. Cinquetti, M. Sinagra, G. Ramani, F. Fabris, E. Stolfo, D. Artico, J. Miani, D. Fresco, C. Daneluzzi, C. Proclemer, A. Cicoira, M. Zanolla, L. Marchese, G. Torelli, F. Vassanelli, C. Voronina, N. Erglis, A. Tamakauskas, V. Smalinskas, V. Karaliute, R. Petraskiene, I. Kazakauskaite, E. Rumbinaite, E. Kavoliuniene, A. Vysniauskas, V. Brazyte-Ramanauskiene, R. Petraskiene, D. Stankala, S. Switala, P. Juszczyk, Z. Sinkiewicz, W. Gilewski, W. Pietrzak, J. Orzel, T. Kasztelowicz, P. Kardaszewicz, P. Lazorko-Piega, M. Gabryel, J. Mosakowska, K. Bellwon, J. Rynkiewicz, A. Raczak, G. Lewicka, E. Dabrowska-Kugacka, A. Bartkowiak, R. Sosnowska-Pasiarska, B. Wozakowska-Kaplon, B. Krzeminski, A. Zabojszcz, M. Mirek-Bryniarska, E. Grzegorzko, A. Bury, K. Nessler, J. Zalewski, J. Furman, A. Broncel, M. Poliwczak, A. Bala, A. Zycinski, P. Rudzinska, M. Jankowski, L. Kasprzak, J.D. Michalak, L. Soska, K.W. Drozdz, J. Huziuk, I. Retwinski, A. Flis, P. Weglarz, J. Bodys, A. Grajek, S. Kaluzna-Oleksy, M. Straburzynska-Migaj, E. Dankowski, R. Szymanowska, K. Grabia, J. Szyszka, A. Nowicka, A. Samcik, M. Wolniewicz, L. Baczynska, K. Komorowska, K. Poprawa, I. Komorowska, E. Sajnaga, D. Zolbach, A. Dudzik-Plocica, A. Abdulkarim, A.-F. Lauko-Rachocka, A. Kaminski, L. Kostka, A. Cichy, A. Ruszkowski, P. Splawski, M. Fitas, G. Szymczyk, A. Serwicka, A. Fiega, A. Zysko, D. Krysiak, W. Szabowski, S. Skorek, E. Pruszczyk, P. Bienias, P. Ciurzynski, M. Welnicki, M. Mamcarz, A. Folga, A. Zielinski, T. Rywik, T. Leszek, P. Sobieszczanska-Malek, M. Piotrowska, M. Kozar-Kaminska, K. Komuda, K. Wisniewska, J. Tarnowska, A. Balsam, P. Marchel, M. Opolski, G. Kaplon-Cieslicka, A. Gil, R.J. Mozenska, O. Byczkowska, K. Gil, K. Pawlak, A. Michalek, A. Krzesinski, P. Piotrowicz, K. Uzieblo-Zyczkowska, B. Stanczyk, A. Skrobowski, A. Ponikowski, P. Jankowska, E. Rozentryt, P. Polonski, L. Gadula-Gacek, E. Nowalany-Kozielska, E. Kuczaj, A. Kalarus, Z. Szulik, M. Przybylska, K. Klys, J. Prokop-Lewicka, G. Kleinrok, A. Aguiar, C.T. Ventosa, A. Pereira, S. Faria, R. Chin, J. De Jesus, I. Santos, R. Silva, P. Moreno, N. Queirós, C. Lourenço, C. Pereira, A. Castro, A. Andrade, A. Guimaraes, T.O. Martins, S. Placido, R. Lima, G. Brito, D. Francisco, A.R. Cardiga, R. Proenca, M. Araujo, I. Marques, F. Moura, B. Leite, S. Campelo, M. Silva-Cardoso, J. Rodrigues, J. Rangel, I. Martins, E. Correia, A.S. Peres, M. Marta, L. da Silva, G.F. Severino, D. Durao, D. Leao, S. Magalhaes, P. Moreira, I. Cordeiro, A.F. Ferreira, C. Araujo, C. Ferreira, A. Baptista, A. Radoi, M. Bicescu, G. Vinereanu, D. Sinescu, C.-J. Macarie, C. Popescu, R. Daha, I. Dan, G.-A. Stanescu, C. Dan, A. Craiu, E. Nechita, E. Aursulesei, V. Christodorescu, R. Otasevic, P. Simeunovic, D. Ristic, A.D. Celic, V. Pavlovic-Kleut, M. Lazic, J.S. Stojcevski, B. Pencic, B. Stevanovic, A. Andric, A. Iric-Cupic, V. Jovic, M. Davidovic, G. Milanov, S. Mitic, V. Atanaskovic, V. Antic, S. Pavlovic, M. Stanojevic, D. Stoickov, V. Ilic, S. Ilic, M.D. Petrovic, D. Stojsic, S. Kecojevic, S. Dodic, S. Adic, N.C. Cankovic, M. Stojiljkovic, J. Mihajlovic, B. Radin, A. Radovanovic, S. Krotin, M. Klabnik, A. Goncalvesova, E. Pernicky, M. Murin, J. Kovar, F. Kmec, J. Semjanova, H. Strasek, M. Iskra, M.S. Ravnikar, T. Suligoj, N.C. Komel, J. Fras, Z. Jug, B. Glavic, T. Losic, R. Bombek, M. Krajnc, I. Krunic, B. Horvat, S. Kovac, D. Rajtman, D. Cencic, V. Letonja, M. Winkler, R. Valentincic, M. Melihen-Bartolic, C. Bartolic, A. Vrckovnik, M.P. Kladnik, M. Pusnik, C.S. Marolt, A. Klen, J. Drnovsek, B. Leskovar, B. Anguita, M.J.F. Page, J.C.G. Martinez, F.M.S. Andres, J. Bayes-Genis, A. Mirabet, S. Mendez, A. Garcia-Cosio, L. Roig, E. Leon, V. Gonzalez-Costello, J. Muntane, G. Garay, A. Alcade-Martinez, V. Fernandez, S.L. Rivera-Lopez, R. Puga-Martinez, M. Fernandez-Alvarez, M. Serrano-Martinez, J.L. Grille-Cancela, Z. Marzoa-Rivas, R. Blanco-Canosa, P. Paniagua-Martin, M.J. Barge-Caballero, E. Cerdena, I.L. Baldomero, I.F.H. Padron, A.L. Rosillo, S.O. Gonzalez-Gallarza, R.D. Montanes, O.S. Manjavacas, A.M.I. Conde, A.C. Araujo, A. Soria, T. Garcia-Pavia, P. Gomez-Bueno, M. Cobo-Marcos, M. Alonso-Pulpon, L. Cubero, J.S. Sayago, I. Gonzalez-Segovia, A. Briceno, A. Subias, P.E. Hernandez, M.V. Cano, M.J.R. Sanchez, M.A.G. Jimenez, J.F.D. Garrido-Lestache, E.B. Pinilla, J.M.G. de la Villa, B.G. Sahuquillo, A. Marques, R.B. Calvo, F.T. Perez-Martinez, M.T. Gracia-Rodenas, M.R. Garrido-Bravo, I.P. Pastor-Perez, F. Pascual-Figal, D.A. Molina, B.D. Orus, J. Gonzalo, F.E. Bertomeu, V. Valero, R. Martinez-Abellan, R. Quiles, J. Rodrigez-Ortega, J.A. Mateo, I. ElAmrani, A. Fernandez-Vivancos, C. Valero, D.B. Almenar-Bonet, L. Sanchez-Lazaro, I.J. Marques-Sule, E. Facila-Rubio, L. Perez-Silvestre, J. Garcia-Gonzalez, P. Ridocci-Soriano, F. Garcia-Escriva, D. Pellicer-Cabo, A. de la Fuente Galan, L. Diaz, J.L. Platero, A.R. Arias, J.C. Blasco-Peiro, T. Julve, M.S. Sanchez-Insa, E. Aured-Guallar, C. Portoles-Ocampo, A. Melin, M. Hägglund, E. Stenberg, A. Lindahl, I.-M. Asserlund, B. Olsson, L. Dahlström, U. Afzelius, M. Karlström, P. Tengvall, L. Wiklund, P.-A. Olsson, B. Kalayci, S. Temizhan, A. Cavusoglu, Y. Gencer, E. Gunes, H. the European Society of Cardiology Heart Failure Long-Term Registry Investigators Group

Abstract

Aims: This study aimed to assess age- and sex-related differences in management and 1-year risk for all-cause mortality and hospitalization in chronic heart failure (HF) patients. Methods and results: Of 16 354 patients included in the European Society of Cardiology Heart Failure Long-Term Registry, 9428 chronic HF patients were analysed [median age: 66 years; 28.5% women; mean left ventricular ejection fraction (LVEF) 37%]. Rates of use of guideline-directed medical therapy (GDMT) were high (angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, beta-blockers and mineralocorticoid receptor antagonists: 85.7%, 88.7% and 58.8%, respectively). Crude GDMT utilization rates were lower in women than in men (all differences: P ≤ 0.001), and GDMT use became lower with ageing in both sexes, at baseline and at 1-year follow-up. Sex was not an independent predictor of GDMT prescription; however, age >75 years was a significant predictor of GDMT underutilization. Rates of all-cause mortality were lower in women than in men (7.1% vs. 8.7%; P = 0.015), as were rates of all-cause hospitalization (21.9% vs. 27.3%; P 75 years. Conclusions: There was a decline in GDMT use with advanced age in both sexes. Sex was not an independent predictor of GDMT or adverse outcomes. However, age >75 years independently predicted lower GDMT use and higher all-cause mortality in patients with LVEF ≤45%. © 2019 The Authors. European Journal of Heart Failure © 2019 European Society of Cardiology

Published
2020

154. Unravelling the interplay between hyperkalaemia, renin–angiotensin–aldosterone inhibitor use and clinical outcomes. Data from 9222 chronic heart failure patients of the ESC-HFA-EORP Heart Failure Long-Term Registry

Author

Rossignol, P. Lainscak, M. Crespo-Leiro, M.G. Laroche, C. Piepoli, M.F. Filippatos, G. Rosano, G.M.C. Savarese, G. Anker, S.D. Seferovic, P.M. Ruschitzka, F. Coats, A.J.S. Mebazaa, A. McDonagh, T. Sahuquillo, A. Penco, M. Maggioni, A.P. Lund, L.H. Christopher Peter Gale, G.B. Branko Beleslin, R.S. Andrzej Budaj, P.L. Ovidiu Chioncel, R.O. Nikolaos Dagres, D.E. Nicolas Danchin, F.R. David Erlinge, S.E. Jonathan Emberson, G.B. Michael Glikson, I.L. Alastair Gray, G.B. Meral Kayikcioglu, T.R. Aldo Maggioni, I.T. Klaudia Vivien Nagy, H.U. Aleksandr Nedoshivin, R.U. Anna-Sonia Petronio, I.T. Jolien Roos-Hesselink, N.L. Lars Wallentin, S.E. Uwe Zeymer, D.E. Anker, S. Mebazaa, A. Coats, A. Filippatos, G. Ferrari, R. Maggioni, A.P. Goda, A. Diez, M. Fernandez, A. Fruhwald, F. Fazlibegovic, E. Gatzov, P. Kurlianskaya, A. Hullin, R. Christodoulides, T. Hradec, J. Nielsen, O.W. Nedjar, R. Uuetoa, T. Hassanein, M. Jimenez, J.F.D. Harjola, V.P. Logeart, D. Chumburidze, V. Tousoulis, D. Milicic, D. Merkely, B. O'Donoghue, E. Amir, O. Shotan, A. Shafie, D. Metra, M. Matsumori, A. Mirrakhimov, E. Kavoliuniene, A. Erglis, A. Vataman, E. Otljanska, M. Kostovska, E.S. DeMarco, D.C. Drozdz, J. Fonseca, C. Chioncel, O. Dekleva, M. Shkolnik, E. Dahlstrom, U. Lainscak, M. Goncalvesova, E. Temizhan, A. Estrago, V. Bajraktari, G. Auer, J. Ablasser, K. Fruhwald, F. Dolze, T. Brandner, K. Gstrein, S. Poelzl, G. Moertl, D. Reiter, S. Podczeck-Schweighofer, A. Muslibegovic, A. Vasilj, M. Fazlibegovic, E. Cesko, M. Zelenika, D. Palic, B. Pravdic, D. Cuk, D. Vitlianova, K. Katova, T. Velikov, T. Kurteva, T. Gatzov, P. Kamenova, D. Antova, M. Sirakova, V. Krejci, J. Mikolaskova, M. Spinar, J. Krupicka, J. Malek, F. Hegarova, M. Lazarova, M. Monhart, Z. Hassanein, M. Sobhy, M. El Messiry, F. El Shazly, A.H. Elrakshy, Y. Youssef, A. Moneim, A.A. Noamany, M. Reda, A. Dayem, T.K.A. Farag, N. Halawa, S.I. Hamid, M.A. Said, K. Saleh, A. Ebeid, H. Hanna, R. Aziz, R. Louis, O. Enen, M.A. Ibrahim, B.S. Nasr, G. Elbahry, A. Sobhy, H. Ashmawy, M. Gouda, M. Aboleineen, W. Bernard, Y. Luporsi, P. Meneveau, N. Pillot, M. Morel, M. Seronde, M.-F. Schiele, F. Briand, F. Delahaye, F. Damy, T. Eicher, J.-C. de Groote, P. Fertin, M. Lamblin, N. Isnard, R. Lefol, C. Thevenin, S. Hagege, A. Jondeau, G. Logeart, D. Le Marcis, V. Ly, J.-F. Coisne, D. Lequeux, B. Le Moal, V. Mascle, S. Lotton, P. Behar, N. Donal, E. Thebault, C. Ridard, C. Reynaud, A. Basquin, A. Bauer, F. Codjia, R. Galinier, M. Tourikis, P. Stavroula, M. Tousoulis, D. Stefanadis, C. Chrysohoou, C. Kotrogiannis, I. Matzaraki, V. Dimitroula, T. Karavidas, A. Tsitsinakis, G. Kapelios, C. Nanas, J. Kampouri, H. Nana, E. Kaldara, E. Eugenidou, A. Vardas, P. Saloustros, I. Patrianakos, A. Tsaknakis, T. Evangelou, S. Nikoloulis, N. Tziourganou, H. Tsaroucha, A. Papadopoulou, A. Douras, A. Polgar, L. Kosztin, A. Nyolczas, N. Nagy, A.C. Halmosi, R. Elber, J. Alony, I. Shotan, A. Fuhrmann, A.V. Amir, O. Romano, S. Marcon, S. Penco, M. Di Mauro, M. Lemme, E. Carubelli, V. Rovetta, R. Bulgari, M. Quinzani, F. Lombardi, C. Bosi, S. Schiavina, G. Squeri, A. Barbieri, A. Di Tano, G. Pirelli, S. Ferrari, R. Fucili, A. Passero, T. Musio, S. Di Biase, M. Correale, M. Salvemini, G. Brognoli, S. Zanelli, E. Giordano, A. Agostoni, P. Italiano, G. Salvioni, E. Copelli, S. Modena, M.G. Reggianini, L. Valenti, C. Olaru, A. Bandino, S. Deidda, M. Mercuro, G. Dessalvi, C.C. Marino, P.N. Di Ruocco, M.V. Sartori, C. Piccinino, C. Parrinello, G. Licata, G. Torres, D. Giambanco, S. Busalacchi, S. Arrotti, S. Novo, S. Inciardi, R.M. Pieri, P. Chirco, P.R. Galifi, M.A. Teresi, G. Buccheri, D. Minacapelli, A. Veniani, M. Frisinghelli, A. Priori, S.G. Cattaneo, S. Opasich, C. Gualco, A. Pagliaro, M. Mancone, M. Fedele, F. Cinque, A. Vellini, M. Scarfo, I. Romeo, F. Ferraiuolo, F. Sergi, D. Anselmi, M. Melandri, F. Leci, E. Iori, E. Bovolo, V. Pidello, S. Frea, S. Bergerone, S. Botta, M. Canavosio, F.G. Gaita, F. Merlo, M. Cinquetti, M. Sinagra, G. Ramani, F. Fabris, E. Stolfo, D. Artico, J. Miani, D. Fresco, C. Daneluzzi, C. Proclemer, A. Cicoira, M. Zanolla, L. Marchese, G. Torelli, F. Vassanelli, C. Voronina, N. Tamakauskas, V. Smalinskas, V. Karaliute, R. Petraskiene, I. Kazakauskaite, E. Rumbinaite, E. Kavoliuniene, A. Vysniauskas, V. Brazyte-Ramanauskiene, R. Petraskiene, D. Stankala, S. Switala, P. Juszczyk, Z. Sinkiewicz, W. Gilewski, W. Pietrzak, J. Orzel, T. Kasztelowicz, P. Kardaszewicz, P. Lazorko-Piega, M. Gabryel, J. Mosakowska, K. Bellwon, J. Rynkiewicz, A. Raczak, G. Lewicka, E. Dabrowska-Kugacka, A. Bartkowiak, R. Sosnowska-Pasiarska, B. Wozakowska-Kaplon, B. Krzeminski, A. Zabojszcz, M. Mirek-Bryniarska, E. Grzegorzko, A. Bury, K. Nessler, J. Zalewski, J. Furman, A. Broncel, M. Poliwczak, A. Bala, A. Zycinski, P. Rudzinska, M. Jankowski, L. Kasprzak, J.D. Michalak, L. Soska, K.W. Drozdz, J. Huziuk, I. Retwinski, A. Flis, P. Weglarz, J. Bodys, A. Grajek, S. Kaluzna-Oleksy, M. Straburzynska-Migaj, E. Dankowski, R. Szymanowska, K. Grabia, J. Szyszka, A. Nowicka, A. Samcik, M. Wolniewicz, L. Baczynska, K. Komorowska, K. Poprawa, I. Komorowska, E. Sajnaga, D. Zolbach, A. Dudzik-Plocica, A. Abdulkarim, A.-F. Lauko-Rachocka, A. Kaminski, L. Kostka, A. Cichy, A. Ruszkowski, P. Splawski, M. Fitas, G. Szymczyk, A. Serwicka, A. Fiega, A. Zysko, D. Krysiak, W. Szabowski, S. Skorek, E. Pruszczyk, P. Bienias, P. Ciurzynski, M. Welnicki, M. Mamcarz, A. Folga, A. Zielinski, T. Rywik, T. Leszek, P. Sobieszczanska-Malek, M. Piotrowska, M. Kozar-Kaminska, K. Komuda, K. Wisniewska, J. Tarnowska, A. Balsam, P. Marchel, M. Opolski, G. Kaplon-Cieslicka, A. Gil, R.J. Mozenska, O. Byczkowska, K. Gil, K. Pawlak, A. Michalek, A. Krzesinski, P. Piotrowicz, K. Uzieblo-Zyczkowska, B. Stanczyk, A. Skrobowski, A. Ponikowski, P. Jankowska, E. Rozentryt, P. Polonski, L. Gadula-Gacek, E. Nowalany-Kozielska, E. Kuczaj, A. Kalarus, Z. Szulik, M. Przybylska, K. Klys, J. Prokop-Lewicka, G. Kleinrok, A. Aguiar, C.T. Ventosa, A. Pereira, S. Faria, R. Chin, J. De Jesus, I. Santos, R. Silva, P. Moreno, N. Queirós, C. Lourenço, C. Pereira, A. Castro, A. Andrade, A. Guimaraes, T.O. Martins, S. Placido, R. Lima, G. Brito, D. Francisco, A.R. Cardiga, R. Proenca, M. Araujo, I. Marques, F. Fonseca, C. Moura, B. Leite, S. Campelo, M. Silva-Cardoso, J. Rodrigues, J. Rangel, I. Martins, E. Correia, A.S. Peres, M. Marta, L. da Silva, G.F. Severino, D. Durao, D. Leao, S. Magalhaes, P. Moreira, I. Cordeiro, A.F. Ferreira, C. Araujo, C. Ferreira, A. Baptista, A. Radoi, M. Bicescu, G. Vinereanu, D. Sinescu, C.-J. Macarie, C. Popescu, R. Daha, I. Dan, G.-A. Stanescu, C. Dan, A. Craiu, E. Nechita, E. Aursulesei, V. Christodorescu, R. Otasevic, P. Seferovic, P.M. Simeunovic, D. Ristic, A.D. Celic, V. Pavlovic-Kleut, M. Lazic, J.S. Stojcevski, B. Pencic, B. Stevanovic, A. Andric, A. Simić, D. Ašanin, M. Iric-Cupic, V. Jovic, M. Davidovic, G. Milanov, S. Mitic, V. Atanaskovic, V. Antic, S. Pavlovic, M. Stanojevic, D. Stoickov, V. Ilic, S. Ilic, M.D. Petrovic, D. Stojsic, S. Kecojevic, S. Dodic, S. Adic, N.C. Cankovic, M. Stojiljkovic, J. Mihajlovic, B. Radin, A. Radovanovic, S. Krotin, M. Klabnik, A. Goncalvesova, E. Pernicky, M. Murin, J. Kovar, F. Kmec, J. Semjanova, H. Strasek, M. Iskra, M.S. Ravnikar, T. Suligoj, N.C. Komel, J. Fras, Z. Jug, B. Glavic, T. Losic, R. Bombek, M. Krajnc, I. Krunic, B. Horvat, S. Kovac, D. Rajtman, D. Cencic, V. Letonja, M. Winkler, R. Valentincic, M. Melihen-Bartolic, C. Bartolic, A. Vrckovnik, M.P. Kladnik, M. Pusnik, C.S. Marolt, A. Klen, J. Drnovsek, B. Leskovar, B. Anguita, M.J.F. Page, J.C.G. Martinez, F.M.S. Andres, J. Bayes-Genis, A. Mirabet, S. Mendez, A. Garcia-Cosio, L. Roig, E. Leon, V. Gonzalez-Costello, J. Muntane, G. Garay, A. Alcade-Martinez, V. Fernandez, S.L. Rivera-Lopez, R. Puga-Martinez, M. Fernandez-Alvarez, M. Serrano-Martinez, J.L. Grille-Cancela, Z. Marzoa-Rivas, R. Blanco-Canosa, P. Paniagua-Martin, M.J. Barge-Caballero, E. Cerdena, I.L. Baldomero, I.F.H. Padron, A.L. Rosillo, S.O. Gonzalez-Gallarza, R.D. Montanes, O.S. Manjavacas, A.M.I. Conde, A.C. Araujo, A. Soria, T. Garcia-Pavia, P. Gomez-Bueno, M. Cobo-Marcos, M. Alonso-Pulpon, L. Cubero, J.S. Sayago, I. Gonzalez-Segovia, A. Briceno, A. Subias, P.E. Hernandez, M.V. Cano, M.J.R. Sanchez, M.A.G. Jimenez, J.F.D. Garrido-Lestache, E.B. Pinilla, J.M.G. de la Villa, B.G. Sahuquillo, A. Marques, R.B. Calvo, F.T. Perez-Martinez, M.T. Gracia-Rodenas, M.R. Garrido-Bravo, I.P. Pastor-Perez, F. Pascual-Figal, D.A. Molina, B.D. Orus, J. Gonzalo, F.E. Bertomeu, V. Valero, R. Martinez-Abellan, R. Quiles, J. Rodrigez-Ortega, J.A. Mateo, I. ElAmrani, A. Fernandez-Vivancos, C. Valero, D.B. Almenar-Bonet, L. Sanchez-Lazaro, I.J. Marques-Sule, E. Facila-Rubio, L. Perez-Silvestre, J. Garcia-Gonzalez, P. Ridocci-Soriano, F. Garcia-Escriva, D. Pellicer-Cabo, A. de la Fuente Galan, L. Diaz, J.L. Platero, A.R. Arias, J.C. Blasco-Peiro, T. Julve, M.S. Sanchez-Insa, E. Aured-Guallar, C. Portoles-Ocampo, A. Melin, M. Hägglund, E. Stenberg, A. Lindahl, I.-M. Asserlund, B. Olsson, L. Dahlström, U. Afzelius, M. Karlström, P. Tengvall, L. Olsson, B. Kalayci, S. Temizhan, A. Cavusoglu, Y. Gencer, E. Yilmaz, M.B. Gunes, H.

Subjects
cardiovascular diseases
Abstract

Aims: We assessed the interplay between hyperkalaemia (HK) and renin–angiotensin–aldosterone system inhibitor (RAASi) use, dose and discontinuation, and their association with all-cause or cardiovascular death in patients with chronic heart failure (HF). We hypothesized that HK-associated increased death may be related to RAASi withdrawal. Methods and results: The ESC-HFA-EORP Heart Failure Long-Term Registry was used. Among 9222 outpatients (HF with reduced ejection fraction: 60.6%, HF with mid-range ejection fraction: 22.9%, HF with preserved ejection fraction: 16.5%) from 31 countries, 16.6% had HK (≥5.0 mmol/L) at baseline. Angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) was used in 88.3%, a mineralocorticoid receptor antagonist (MRA) in 58.7%, or a combination in 53.2%; of these, at ≥50% of target dose in ACEi: 61.8%; ARB: 64.7%; and MRA: 90.3%. At a median follow-up of 12.2 months, there were 789 deaths (8.6%). Both hypokalaemia and HK were independently. associated with higher mortality, and ACEi/ARB prescription at baseline with lower mortality. MRA prescription was not retained in the model. In multivariable analyses, HK at baseline was independently associated with MRA non-prescription at baseline and subsequent discontinuation. When considering subsequent discontinuation of RAASi (instead of baseline use), HK was no longer found associated with all-cause deaths. Importantly, all RAASi (ACEi, ARB, or MRA) discontinuations were strongly associated with mortality. Conclusions: In HF, hyper- and hypokalaemia were associated with mortality. However, when adjusting for RAASi discontinuation, HK was no longer associated with mortality, suggesting that HK may be a risk marker for RAASi discontinuation rather than a risk factor for worse outcomes. © 2020 European Society of Cardiology

Published
2020

155. Prospective, study comparing the accuracy of two different stool antigen tests (Premier Platinum HpSA and novel ImmunoCard STATI rapid test) for the diagnosis of Helicobacter pylori infection

Author

McNicholl AG, Garre A, Llorca L, Bujanda L, Molina-Infante J, Barenys M, Perez J, Guerrero-Torres MD, Tamayo E, Montes M, Prados-Manzano R, Sanchez-Garcia A, Ramas M, Valdez Blanco VB, Montoro M, Calvet X, Figuerola A, Lario S, Quilez E, Lanas A, Silva-Pomarino P, Perez-Aisa A, Donday MG, Belloc B, Montserrat-Torres A, Fernandez-Moreno N, Ramírez MJ, Alarcon T, and Gisbert JP

Abstract

Background: At present only monoclonal EIA (enzyme-immunoassay) stool antigen-tests have obtained optimal accuracy in the diagnosis of Helicobacter pylori. Our aim was to evaluate the accuracy of two stool antigen-tests, the validated Premier Platinum HpSA PLUS (EIA test) and the newly available ImmunoCard STATI HpSA HD (rapid test) for the initial diagnosis and the confirmation of eradication of H. pylori infection. Patients and methods: Patients with indication of H. pylori diagnosis, or confirmation after treatment were included. Data were coded to protect personal data and ensure blindness between tests. Accuracy was considered as coincident diagnosis with the gold standard (C-13-urea breath test, UBT). The EIA was used as a bench standard. All stool tests were performed in duplicate. Results: 264 patients completed the protocol (100 naive, 164 post-eradication). Average age was 52 years, 61% women, 11% ulcer. Positive diagnoses by UBT were 41% for naive and 17% for post-eradication. Overall ImmunoCard and EIA accuracies were respectively 91% (95%c.i. =88-94%) and 89% (86-93%), sensitivities 72% (67-78%) and 72% (67-78%), and specificities 98% (96-100%), and 95% (92-97%). Concordance between ImmunoCard and EIA was 95% (93-98%). Discussion: Our results indicate that the newly available ImmunoCard rapid stool antigen-test achieves 90% accuracy, with high specificity but suboptimal sensitivity. The ImmunoCard attained equivalent accuracies as the EIA bench standard, with 95% concordance. (C) 2019 Elsevier Espana, S.L.U. All rights reserved.

Published
2020

162. Texture and terahertz analysis of YBa2Cu3O7 grown onto LaAlO3 by the chemical solution deposition technique.

Author

Sanchez Cornejo, H., De Los Santos Valladares, L., Kamboj, V. S., Bustamante Dominguez, A., González, J. C., Osorio Anaya, A. M., Moreno, N. O., Beere, H. E., Ritchie, D. A., Newton, P. J., and Barnes, C. H. W.

Subjects
CHEMICAL solution deposition, X-ray diffraction, MAGNETIZATION, SUPERCONDUCTORS, ABSORPTION (Physiology)
Abstract

We analyze in-plane and out-of-plane texture and terahertz analysis of a YBa2Cu3O7-δ (YBCO) film deposited by chemical solution deposition technique onto LaAlO3 (100) substrate. X-ray diffraction reveals the presence of (00l) reflections for the YBCO phase. The out-of-plane texture, measured by a rocking curve, shows two sub-layers with Δω = 0.45° and 1.8°. The value of the c-axis fraction of the crystallites is 81%. Also, the in-plane texture was studied by ϕ-scan measurements of the (102) reflection, displaying mostly a colony of c-axis oriented grains, and two colonies of a-axis oriented grains onto the YBCO surface. In addition, the temperature dependence of the magnetization measurement revealed a critical temperature of 90 K, typical for YBCO superconductor material. From the temperature-dependent optical conductivity of YBCO, we observe an absorption feature at ≈1.57 THz, which redshifts with increasing temperature. [ABSTRACT FROM AUTHOR]

Published
2021
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166. Increasing consensus on terminology of Achilles tendon-related disorders.

Author

Opdam, K. T. M., Zwiers, R., Wiegerinck, J. I., van Dijk, C. N., Ankleplatform Study Collaborative –Science of Variation Group, Topliss, C., Gaspar, A. R., Moreno, N., Puttaraju, A., Lau, Y. J., Grauls, A., Nery, C., Mora, A. D., Tsoukas, D., Spanos, I., Koukoulias, N., Lijoi, F., Yasui, Y., Guzenko, D., and van Sterkenburg, M.

Subjects
ACHILLES tendon injury treatment, ACHILLES tendon rupture, FOOT dislocation, HISTOPATHOLOGY, ORTHOPEDICS
Abstract

Purpose: Aims of this study are to evaluate the current terminology and assess the influence of the latest proposals on the terminology used for Achilles tendon-related disorders in both daily practice and literature. Methods: (1) All orthopedic surgeons experienced in the field of foot and ankle surgery of the Ankleplatform Study Group were invited to participate in this survey by email. They were requested to fill out a survey on terminology in six typical cases with Achilles tendon-related disorders. (2) A systematic literature search of Achilles tendon-related disorders was performed in eight foot and ankle journals in Medline, Embase (Classic) from 2000 to 2016. All extracted terms were counted and compared to the terminology proposals, based on anatomic location, symptoms, clinical findings and histopathology. Results: (1) In total, 141 of the 283 (50%) orthopedic surgeons responded to the survey. In five out of six cases with Achilles tendon-related disorders, the majority gave an answer according to latest proposals. (2) An overview of terminology used for Achilles tendon-related disorders from 2000 to 2016 shows an increase in use of terminology according to the latest proposals based on anatomic location, symptoms, clinical findings and histopathology. Conclusion: The revised terminology for Achilles tendon-related disorders based on anatomic location, symptoms, clinical findings and histopathology is used by the majority of orthopedic surgeons and is increasingly used in the literature. However, the indistinct Haglund eponyms are still frequently used in Achilles tendon-related terminology. Level of evidence: Level IV. [ABSTRACT FROM AUTHOR]

Published
2021
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167. Acute heart failure congestion and perfusion status – impact of the clinical classification on in-hospital and long-term outcomes; insights from the ESC-EORP-HFA Heart Failure Long-Term Registry

Author

Chioncel, O. Mebazaa, A. Maggioni, A.P. Harjola, V.-P. Rosano, G. Laroche, C. Piepoli, M.F. Crespo-Leiro, M.G. Lainscak, M. Ponikowski, P. Filippatos, G. Ruschitzka, F. Seferovic, P. Coats, A.J.S. Lund, L.H. Auer, J. Ablasser, K. Fruhwald, F. Dolze, T. Brandner, K. Gstrein, S. Poelzl, G. Moertl, D. Reiter, S. Podczeck-Schweighofer, A. Muslibegovic, A. Vasilj, M. Fazlibegovic, E. Cesko, M. Zelenika, D. Palic, B. Pravdic, D. Cuk, D. Vitlianova, K. Katova, T. Velikov, T. Kurteva, T. Gatzov, P. Kamenova, D. Antova, M. Sirakova, V. Krejci, J. Mikolaskova, M. Spinar, J. Krupicka, J. Malek, F. Hegarova, M. Lazarova, M. Monhart, Z. Hassanein, M. Sobhy, M. El Messiry, F. El Shazly, A.H. Elrakshy, Y. Youssef, A. Moneim, A.A. Noamany, M. Reda, A. Dayem, T.K.A. Farag, N. Halawa, S.I. Hamid, M.A. Said, K. Saleh, A. Ebeid, H. Hanna, R. Aziz, R. Louis, O. Enen, M.A. Ibrahim, B.S. Nasr, G. Elbahry, A. Sobhy, H. Ashmawy, M. Gouda, M. Aboleineen, W. Bernard, Y. Luporsi, P. Meneveau, N. Pillot, M. Morel, M. Seronde, M.-F. Schiele, F. Briand, F. Delahaye, F. Damy, T. Eicher, J.-C. de Groote, P. Fertin, M. Lamblin, N. Isnard, R. Lefol, C. Thevenin, S. Hagege, A. Jondeau, G. Logeart, D. Le Marcis, V. Ly, J.-F. Coisne, D. Lequeux, B. Le Moal, V. Mascle, S. Lotton, P. Behar, N. Donal, E. Thebault, C. Ridard, C. Reynaud, A. Basquin, A. Bauer, F. Codjia, R. Galinier, M. Tourikis, P. Stavroula, M. Tousoulis, D. Stefanadis, C. Chrysohoou, C. Kotrogiannis, I. Matzaraki, V. Dimitroula, T. Karavidas, A. Tsitsinakis, G. Kapelios, C. Nanas, J. Kampouri, H. Nana, E. Kaldara, E. Eugenidou, A. Vardas, P. Saloustros, I. Patrianakos, A. Tsaknakis, T. Evangelou, S. Nikoloulis, N. Tziourganou, H. Tsaroucha, A. Papadopoulou, A. Douras, A. Polgar, L. Merkely, B. Kosztin, A. Nyolczas, N. Nagy, A.C. Halmosi, R. Elber, J. Alony, I. Shotan, A. Fuhrmann, A.V. Amir, O. Romano, S. Marcon, S. Penco, M. Di Mauro, M. Lemme, E. Carubelli, V. Rovetta, R. Metra, M. Bulgari, M. Quinzani, F. Lombardi, C. Bosi, S. Schiavina, G. Squeri, A. Barbieri, A. Di Tano, G. Pirelli, S. Ferrari, R. Fucili, A. Passero, T. Musio, S. Di Biase, M. Correale, M. Salvemini, G. Brognoli, S. Zanelli, E. Giordano, A. Agostoni, P. Italiano, G. Salvioni, E. Copelli, S. Modena, M.G. Reggianini, L. Valenti, C. Olaru, A. Bandino, S. Deidda, M. Mercuro, G. Dessalvi, C.C. Marino, P.N. Di Ruocco, M.V. Sartori, C. Piccinino, C. Parrinello, G. Licata, G. Torres, D. Giambanco, S. Busalacchi, S. Arrotti, S. Novo, S. Inciardi, R.M. Pieri, P. Chirco, P.R. Galifi, M.A. Teresi, G. Buccheri, D. Minacapelli, A. Veniani, M. Frisinghelli, A. Priori, S.G. Cattaneo, S. Opasich, C. Gualco, A. Pagliaro, M. Mancone, M. Fedele, F. Cinque, A. Vellini, M. Scarfo, I. Romeo, F. Ferraiuolo, F. Sergi, D. Anselmi, M. Melandri, F. Leci, E. Iori, E. Bovolo, V. Pidello, S. Frea, S. Bergerone, S. Botta, M. Canavosio, F.G. Gaita, F. Merlo, M. Cinquetti, M. Sinagra, G. Ramani, F. Fabris, E. Stolfo, D. Artico, J. Miani, D. Fresco, C. Daneluzzi, C. Proclemer, A. Cicoira, M. Zanolla, L. Marchese, G. Torelli, F. Vassanelli, C. Voronina, N. Erglis, A. Tamakauskas, V. Smalinskas, V. Karaliute, R. Petraskiene, I. Kazakauskaite, E. Rumbinaite, E. Kavoliuniene, A. Vysniauskas, V. Brazyte-Ramanauskiene, R. Petraskiene, D. Stankala, S. Switala, P. Juszczyk, Z. Sinkiewicz, W. Gilewski, W. Pietrzak, J. Orzel, T. Kasztelowicz, P. Kardaszewicz, P. Lazorko-Piega, M. Gabryel, J. Mosakowska, K. Bellwon, J. Rynkiewicz, A. Raczak, G. Lewicka, E. Dabrowska-Kugacka, A. Bartkowiak, R. Sosnowska-Pasiarska, B. Wozakowska-Kaplon, B. Krzeminski, A. Zabojszcz, M. Mirek-Bryniarska, E. Grzegorzko, A. Bury, K. Nessler, J. Zalewski, J. Furman, A. Broncel, M. Poliwczak, A. Bala, A. Zycinski, P. Rudzinska, M. Jankowski, L. Kasprzak, J.D. Michalak, L. Soska, K.W. Drozdz, J. Huziuk, I. Retwinski, A. Flis, P. Weglarz, J. Bodys, A. Grajek, S. Kaluzna-Oleksy, M. Straburzynska-Migaj, E. Dankowski, R. Szymanowska, K. Grabia, J. Szyszka, A. Nowicka, A. Samcik, M. Wolniewicz, L. Baczynska, K. Komorowska, K. Poprawa, I. Komorowska, E. Sajnaga, D. Zolbach, A. Dudzik-Plocica, A. Abdulkarim, A.-F. Lauko-Rachocka, A. Kaminski, L. Kostka, A. Cichy, A. Ruszkowski, P. Splawski, M. Fitas, G. Szymczyk, A. Serwicka, A. Fiega, A. Zysko, D. Krysiak, W. Szabowski, S. Skorek, E. Pruszczyk, P. Bienias, P. Ciurzynski, M. Welnicki, M. Mamcarz, A. Folga, A. Zielinski, T. Rywik, T. Leszek, P. Sobieszczanska-Malek, M. Piotrowska, M. Kozar-Kaminska, K. Komuda, K. Wisniewska, J. Tarnowska, A. Balsam, P. Marchel, M. Opolski, G. Kaplon-Cieslicka, A. Gil, R.J. Mozenska, O. Byczkowska, K. Gil, K. Pawlak, A. Michalek, A. Krzesinski, P. Piotrowicz, K. Uzieblo-Zyczkowska, B. Stanczyk, A. Skrobowski, A. Jankowska, E. Rozentryt, P. Polonski, L. Gadula-Gacek, E. Nowalany-Kozielska, E. Kuczaj, A. Kalarus, Z. Szulik, M. Przybylska, K. Klys, J. Prokop-Lewicka, G. Kleinrok, A. Aguiar, C.T. Ventosa, A. Pereira, S. Faria, R. Chin, J. De Jesus, I. Santos, R. Silva, P. Moreno, N. Queirós, C. Lourenço, C. Pereira, A. Castro, A. Andrade, A. Guimaraes, T.O. Martins, S. Placido, R. Lima, G. Brito, D. Francisco, A.R. Cardiga, R. Proenca, M. Araujo, I. Marques, F. Fonseca, C. Moura, B. Leite, S. Campelo, M. Silva-Cardoso, J. Rodrigues, J. Rangel, I. Martins, E. Correia, A.S. Peres, M. Marta, L. da Silva, G.F. Severino, D. Durao, D. Leao, S. Magalhaes, P. Moreira, I. Cordeiro, A.F. Ferreira, C. Araujo, C. Ferreira, A. Baptista, A. Radoi, M. Bicescu, G. Vinereanu, D. Sinescu, C.-J. Macarie, C. Popescu, R. Daha, I. Dan, G.-A. Stanescu, C. Dan, A. Craiu, E. Nechita, E. Aursulesei, V. Christodorescu, R. Otasevic, P. Seferovic, P.M. Simeunovic, D. Ristic, A.D. Celic, V. Pavlovic-Kleut, M. Lazic, J.S. Stojcevski, B. Pencic, B. Stevanovic, A. Andric, A. Iric-Cupic, V. Jovic, M. Davidovic, G. Milanov, S. Mitic, V. Atanaskovic, V. Antic, S. Pavlovic, M. Stanojevic, D. Stoickov, V. Ilic, S. Ilic, M.D. Petrovic, D. Stojsic, S. Kecojevic, S. Dodic, S. Adic, N.C. Cankovic, M. Stojiljkovic, J. Mihajlovic, B. Radin, A. Radovanovic, S. Krotin, M. Klabnik, A. Goncalvesova, E. Pernicky, M. Murin, J. Kovar, F. Kmec, J. Semjanova, H. Strasek, M. Iskra, M.S. Ravnikar, T. Suligoj, N.C. Komel, J. Fras, Z. Jug, B. Glavic, T. Losic, R. Bombek, M. Krajnc, I. Krunic, B. Horvat, S. Kovac, D. Rajtman, D. Cencic, V. Letonja, M. Winkler, R. Valentincic, M. Melihen-Bartolic, C. Bartolic, A. Vrckovnik, M.P. Kladnik, M. Pusnik, C.S. Marolt, A. Klen, J. Drnovsek, B. Leskovar, B. Anguita, M.J.F. Page, J.C.G. Martinez, F.M.S. Andres, J. Bayes-Genis, A. Mirabet, S. Mendez, A. Garcia-Cosio, L. Roig, E. Leon, V. Gonzalez-Costello, J. Muntane, G. Garay, A. Alcade-Martinez, V. Fernandez, S.L. Rivera-Lopez, R. Puga-Martinez, M. Fernandez-Alvarez, M. Serrano-Martinez, J.L. Crespo-Leiro, M. Grille-Cancela, Z. Marzoa-Rivas, R. Blanco-Canosa, P. Paniagua-Martin, M.J. Barge-Caballero, E. Cerdena, I.L. Baldomero, I.F.H. Padron, A.L. Rosillo, S.O. Gonzalez-Gallarza, R.D. Montanes, O.S. Manjavacas, A.M.I. Conde, A.C. Araujo, A. Soria, T. Garcia-Pavia, P. Gomez-Bueno, M. Cobo-Marcos, M. Alonso-Pulpon, L. Cubero, J.S. Sayago, I. Gonzalez-Segovia, A. Briceno, A. Subias, P.E. Hernandez, M.V. Cano, M.J.R. Sanchez, M.A.G. Jimenez, J.F.D. Garrido-Lestache, E.B. Pinilla, J.M.G. de la Villa, B.G. Sahuquillo, A. Marques, R.B. Calvo, F.T. Perez-Martinez, M.T. Gracia-Rodenas, M.R. Garrido-Bravo, I.P. Pastor-Perez, F. Pascual-Figal, D.A. Molina, B.D. Orus, J. Gonzalo, F.E. Bertomeu, V. Valero, R. Martinez-Abellan, R. Quiles, J. Rodrigez-Ortega, J.A. Mateo, I. ElAmrani, A. Fernandez-Vivancos, C. Valero, D.B. Almenar-Bonet, L. Sanchez-Lazaro, I.J. Marques-Sule, E. Facila-Rubio, L. Perez-Silvestre, J. Garcia-Gonzalez, P. Ridocci-Soriano, F. Garcia-Escriva, D. Pellicer-Cabo, A. de la Fuente Galan, L. Diaz, J.L. Platero, A.R. Arias, J.C. Blasco-Peiro, T. Julve, M.S. Sanchez-Insa, E. Aured-Guallar, C. Portoles-Ocampo, A. Melin, M. Hägglund, E. Stenberg, A. Lindahl, I.-M. Asserlund, B. Olsson, L. Dahlström, U. Afzelius, M. Karlström, P. Tengvall, L. Wiklund, P.-A. Olsson, B. Kalayci, S. Temizhan, A. Cavusoglu, Y. Gencer, E. Yilmaz, M.B. Gunes, H. on behalf of the ESC-EORP-HFA Heart Failure Long-Term Registry Investigators

Abstract

Aims: Classification of acute heart failure (AHF) patients into four clinical profiles defined by evidence of congestion and perfusion is advocated by the 2016 European Society of Cardiology (ESC)guidelines. Based on the ESC-EORP-HFA Heart Failure Long-Term Registry, we compared differences in baseline characteristics, in-hospital management and outcomes among congestion/perfusion profiles using this classification. Methods and results: We included 7865 AHF patients classified at admission as: ‘dry-warm’ (9.9%), ‘wet-warm’ (69.9%), ‘wet-cold’ (19.8%) and ‘dry-cold’ (0.4%). These groups differed significantly in terms of baseline characteristics, in-hospital management and outcomes. In-hospital mortality was 2.0% in ‘dry-warm’, 3.8% in ‘wet-warm’, 9.1% in ‘dry-cold’ and 12.1% in ‘wet-cold’ patients. Based on clinical classification at admission, the adjusted hazard ratios (95% confidence interval) for 1-year mortality were: ‘wet-warm’ vs. ‘dry-warm’ 1.78 (1.43–2.21) and ‘wet-cold’ vs. ‘wet-warm’ 1.33 (1.19–1.48). For profiles resulting from discharge classification, the adjusted hazard ratios (95% confidence interval) for 1-year mortality were: ‘wet-warm’ vs. ‘dry-warm’ 1.46 (1.31–1.63) and ‘wet-cold’ vs. ‘wet-warm’ 2.20 (1.89–2.56). Among patients discharged alive, 30.9% had residual congestion, and these patients had higher 1-year mortality compared to patients discharged without congestion (28.0 vs. 18.5%). Tricuspid regurgitation, diabetes, anaemia and high New York Heart Association class were independently associated with higher risk of congestion at discharge, while beta-blockers at admission, de novo heart failure, or any cardiovascular procedure during hospitalization were associated with lower risk of residual congestion. Conclusion: Classification based on congestion/perfusion status provides clinically relevant information at hospital admission and discharge. A better understanding of the clinical course of the two entities could play an important role towards the implementation of targeted strategies that may improve outcomes. © 2019 The Authors. European Journal of Heart Failure © 2019 European Society of Cardiology

Published
2019

168. Improving science literacy and education through space life sciences

Author

MacLeish, M. Y, Moreno, N. P, Tharp, B. Z, Denton, J. J, Jessup, G, and Clipper, M. C

Subjects
Life Sciences (General)
Abstract

The National Space Biomedical Research Institute (NSBRI) encourages open involvement by scientists and the public at large in the Institute's activities. Through its Education and Public Outreach Program, the Institute is supporting national efforts to improve Kindergarten through grade twelve (K-12) and undergraduate education and to communicate knowledge generated by space life science research to lay audiences. Three academic institution Baylor College of Medicine, Morehouse School of Medicine and Texas A&M University are designing, producing, field-testing, and disseminating a comprehensive array of programs and products to achieve this goal. The objectives of the NSBRI Education and Public Outreach program are to: promote systemic change in elementary and secondary science education; attract undergraduate students--especially those from underrepresented groups--to careers in space life sciences, engineering and technology-based fields; increase scientific literacy; and to develop public and private sector partnerships that enhance and expand NSBRI efforts to reach students and families. c 2001. Elsevier Science Ltd. All rights reserved.

Published
2001
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172. Autoimmune Diseases and Asthma

Author

Díaz-Campos, RM, primary, Bobolea, I, additional, Girón-Matute, W, additional, Guillén-Vera, D, additional, De las Cuevas-Moreno, N, additional, and Melero-Moreno, C, additional

Published
2019
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173. Tectonic evolution of petroleum systems within the onshore Llanos Basin: Insights on the presence of Orinoco heavy oil analogs in Colombia and a comparison with other heavy oil provinces worldwide

Author

Mora, A., primary, García-Bautista, Diego Fernando, additional, Reyes-Harker, A., additional, Parra, M., additional, Blanco, V., additional, Sánchez, N., additional, de la Parra, F., additional, Caballero, V., additional, Rodriguez, G., additional, Ruiz, C., additional, Naranjo, J., additional, Tesón, E., additional, Niño, F., additional, Quintero, I., additional, Moreno, N., additional, Cardozo, Eduardo, additional, Gamba, Nestor, additional, Horton, Brian K., additional, and Arias-Martinez, Juan Pablo, additional

Published
2019
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174. Disruption of FOXF2 as a Likely Cause of Absent Uvula in an Egyptian Family

Author

Seselgyte, R., primary, Bryant, D., additional, Demetriou, C., additional, Ishida, M., additional, Peskett, E., additional, Moreno, N., additional, Morrogh, D., additional, Sell, D., additional, Lees, M., additional, Farrall, M., additional, Moore, G.E., additional, Sommerlad, B., additional, Pauws, E., additional, and Stanier, P., additional

Published
2019
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179. MESO AND RACEMIC 1,1-BIS (BENZYLSULFINYL)-2-ETHYLBUTANE. A b-DISULFOXIDE PRO-LIGAND WITH STERIC RESTRICTIONS

Author

ZÁRRAGA O, M, MORENO N, Y, and FRANCO O, C

Subjects
General Chemistry
Abstract

Coordination chemistry of disulfoxides is of interest in inorganic chemistry given the well-known metal coordination through oxygen or sulfur atoms.¹ Ethylene and propylene bridged disulfoxide pro-ligands, coordinate to metals, forming coordinated and chelated complexes, demonstrating its flexibility in the formation of such complexes.² Some of these compounds have demonstrated interesting properties in medicinal chemistry³ and asymmetric catalysis4 and their synthesis is of importance for bioorganic studies. The presence of two stereogenic centers allows the existence of the meso and racemic forms in disulfoxides. Previous studies on b-disulfoxides5 in our laboratories have led to the synthesis and spectroscopic study (¹H-NMR, FT-IR) of both diastereomeric forms. In this work we report the synthesis and structural analysis of meso-(2)- and racemic-(3)-1,1-bis(benzylsulfinyl)-2-ethylbutane (Scheme1), with high steric requirement around both sulfinyl groups when a branched aliphatic carbon chain is introduced in the a-carbon. An increase in selectivity for small radius metal ions was achieved by compression of the pro-ligand coordination radius. These kind of compounds have not been previously studied.

Published
2016
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180. Un estudio sobre la comprensión de las nociones físicas de la mecánica newtoniana: el caso del centro de masa

Author

Moreno, N., Font Moll, Vicenç, and Angulo, R.G.

Subjects
Mechanics, Comprehension, Mecànica, Comprensió
Abstract

e describe la comprensión del centro de masa a partir de un estudio de caso. La descripción se apoya en el análisis de la producción de un grupo de estudiantes universitarios cuando resuelven algunas tareas planteadas en una muestra representativa de contextos, un contexto mecánico estático y otro dinámico, en los que el centro de masa es importante para su resolución. En el estudio de las concepciones se utilizan y se adaptan algunas herramientas teóricas del enfoque ontosemiótico tales como el de configuración de objetos matemáticos de tipo epistémico y cognitivo. La comparación entre la configuración epistémica, organizada por un docente, y las configuraciones cognitivas de los discentes, muestra que el contexto estático deberá incluir situaciones en las que se favorezca el proceso de idealización, que el uso competente de dicha noción en una tarea concreta provee al alumno de un conocimiento parcial y, por otro lado, que la transferencia del conocimiento de un contexto a otro no es inmediata, pues los alumnos no consideran la complejidad del contexto dinámico.

Published
2018

181. miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models

Author

Cerro-Herreros E, Sabater-Arcis M, Fernandez-Costa J, Moreno N, Perez-Alonso M, Llamusi B, and Artero R

Subjects
musculoskeletal diseases, congenital, hereditary, and neonatal diseases and abnormalities
Abstract

Functional depletion of the alternative splicing factors Muscleblind-like (MBNL 1 and 2) is at the basis of the neuromuscular disease myotonic dystrophy type 1 (DM1). We previously showed the efficacy of miRNA downregulation in Drosophila DM1 model. Here, we screen for miRNAs that regulate MBNL1 and MBNL2 in HeLa cells. We thus identify miR-23b and miR218, and confirm that they downregulate MBNL proteins in this cell line. Antagonists of miR23b and miR-218 miRNAs enhance MBNL protein levels and rescue pathogenic missplicing events in DM1 myoblasts. Systemic delivery of these "antagomiRs" similarly boost MBNL expression and improve DM1-like phenotypes, including splicing alterations, histopathology, and myotonia in the HSA(LR) DM1 model mice. These mammalian data provide evidence for therapeutic blocking of the miRNAs that control Muscleblind-like protein expression in myotonic dystrophy.

Published
2018

182. Therapeutic applications of rose hips from different Rosa species

Author

Mármol, I., Sánchez-De-Diego, C., Jiménez-Moreno, N., Ancín-Azpilicueta, C., and Rodríguez-Yoldi, M.

Abstract

Rosa species, rose hips, are widespread wild plants that have been traditionally used as medicinal compounds for the treatment of a wide variety of diseases. The therapeutic potential of these plants is based on its antioxidant effects caused by or associated with its phytochemical composition, which includes ascorbic acid, phenolic compounds and healthy fatty acids among others. Over the last few years, medicinal interest in rose hips has increased as a consequence of recent research that has studied its potential application as a treatment for several diseases including skin disorders, hepatotoxicity, renal disturbances, diarrhoea, inflammatory disorders, arthritis, diabetes, hyperlipidaemia, obesity and cancer. In this review, the role of different species of Rosa in the prevention of treatment of various disorders related to oxidative stress, is examined, focusing on new therapeutic approaches from a molecular point of view.

Published
2017

183. Predicción probabilística de la existencia de estrellas Cefeidas en la galaxia

Author

Cabañas Hernández, A., primary, Cárdenas, D. L., additional, Damián de la Cruz, E. E., additional, Fortiz Flores, A., additional, Garduño Puga, L. E., additional, Hernández-Armenta, I., additional, Jiménez Blas, J. R., additional, López Jiménez, J., additional, Nava-Moreno, N. A., additional, Perea López, F., additional, Santos-Castillo, R. R., additional, Torres-Muñoz, A., additional, Velasco, P., additional, Torres Campos, A., additional, and Corona Galindo, Manuel Gerardo, additional

Published
2019
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187. Epidemiology, clinical features and outcome of bacteriemia episodes by carbapenemase-producing and non carbapenemase-producing enterobacteriaceae

Author

Chevel, J., primary, Nievas, J., additional, Torres, D., additional, Rearte, A.N., additional, Moreno, N., additional, Bonvehi, P., additional, Temporiti, E., additional, Nicola, F., additional, Smayevsky, J., additional, Zerboni, S., additional, Poletta, F., additional, and Herrera, F., additional

Published
2018
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190. Performance of Prognostic Risk Scores in Chronic Heart Failure Patients Enrolled in the European Society of Cardiology Heart Failure Long-Term Registry

Author

Canepa, Marco, primary, Fonseca, Candida, additional, Chioncel, Ovidiu, additional, Laroche, Cécile, additional, Crespo-Leiro, Maria G., additional, Coats, Andrew J.S., additional, Mebazaa, Alexandre, additional, Piepoli, Massimo F., additional, Tavazzi, Luigi, additional, Maggioni, Aldo P., additional, Crespo-Leiro, M., additional, Anker, S., additional, Mebazaa, A., additional, Coats, A., additional, Filippatos, G., additional, Ferrari, R., additional, Maggioni, A.P., additional, Piepoli, M.F., additional, Amir, O., additional, Chioncel, O., additional, Dahlström, U., additional, Delgado Jimenez, J.F., additional, Drozdz, J., additional, Erglis, A., additional, Fazlibegovic, E., additional, Fonseca, C., additional, Fruhwald, F., additional, Gatzov, P., additional, Goncalvesova, E., additional, Hassanein, M., additional, Hradec, J., additional, Kavoliuniene, A., additional, Lainscak, M., additional, Logeart, D., additional, Merkely, B., additional, Metra, M., additional, Otljanska, M., additional, Seferovic, P.M., additional, Srbinovska Kostovska, E., additional, Temizhan, A., additional, Tousoulis, D., additional, Ferreira, T., additional, Andarala, M., additional, Fiorucci, E., additional, Folkesson Lefrancq, E., additional, Glémot, M., additional, Gracia, G., additional, Konte, M., additional, Laroche, C., additional, McNeill, P.A., additional, Missiamenou, V., additional, Taylor, C., additional, Auer, J., additional, Ablasser, K., additional, Dolze, T., additional, Brandner, K., additional, Gstrein, S., additional, Poelzl, G., additional, Moertl, D., additional, Reiter, S., additional, Podczeck-Schweighofer, A., additional, Muslibegovic, A., additional, Vasilj, M., additional, Cesko, M., additional, Zelenika, D., additional, Palic, B., additional, Pravdic, D., additional, Cuk, D., additional, Vitlianova, K., additional, Katova, T., additional, Velikov, T., additional, Kurteva, T., additional, Kamenova, D., additional, Antova, M., additional, Sirakova, V., additional, Krejci, J., additional, Mikolaskova, M., additional, Spinar, J., additional, Krupicka, J., additional, Malek, F., additional, Hegarova, M., additional, Lazarova, M., additional, Monhart, Z., additional, Sobhy, M., additional, El Messiry, F., additional, El Shazly, A.H., additional, Elrakshy, Y., additional, Youssef, A., additional, Moneim, A.A., additional, Noamany, M., additional, Reda, A., additional, Abdel Dayem, T.K., additional, Farag, N., additional, Ibrahim Halawa, S., additional, Abdel Hamid, M., additional, Said, K., additional, Saleh, A., additional, Ebeid, H., additional, Hanna, R., additional, Aziz, R., additional, Louis, O., additional, Enen, M.A., additional, Ibrahim, B.S., additional, Nasr, G., additional, Elbahry, A., additional, Sobhy, H., additional, Ashmawy, M., additional, Gouda, M., additional, Aboleineen, W., additional, Bernard, Y., additional, Luporsi, P., additional, Meneveau, N., additional, Pillot, M., additional, Morel, M., additional, Seronde, M.-F., additional, Schiele, F., additional, Briand, F., additional, Delahaye, F., additional, Damy, T., additional, Eicher, J.-C., additional, de Groote, P., additional, Fertin, M., additional, Lamblin, N., additional, Isnard, R., additional, Lefol, C., additional, Thevenin, S., additional, Hagege, A., additional, Jondeau, G., additional, Le Marcis, V., additional, Ly, J.-F., additional, Coisne, D., additional, Lequeux, B., additional, Le Moal, V., additional, Mascle, S., additional, Lotton, P., additional, Behar, N., additional, Donal, E., additional, Thebault, C., additional, Ridard, C., additional, Reynaud, A., additional, Basquin, A., additional, Bauer, F., additional, Codjia, R., additional, Galinier, M., additional, Tourikis, P., additional, Stavroula, M., additional, Stefanadis, C., additional, Chrysohoou, C., additional, Kotrogiannis, I., additional, Matzaraki, V., additional, Dimitroula, T., additional, Karavidas, A., additional, Tsitsinakis, G., additional, Kapelios, C., additional, Nanas, J., additional, Kampouri, H., additional, Nana, E., additional, Kaldara, E., additional, Eugenidou, A., additional, Vardas, P., additional, Saloustros, I., additional, Patrianakos, A., additional, Tsaknakis, T., additional, Evangelou, S., additional, Nikoloulis, N., additional, Tziourganou, H., additional, Tsaroucha, A., additional, Papadopoulou, A., additional, Douras, A., additional, Polgar, L., additional, Kosztin, A., additional, Nyolczas, N., additional, Csaba Nagy, A., additional, Halmosi, R., additional, Elber, J., additional, Alony, I., additional, Shotan, A., additional, Vazan Fuhrmann, A., additional, Romano, S., additional, Marcon, S., additional, Penco, M., additional, Di Mauro, M., additional, Lemme, E., additional, Carubelli, V., additional, Rovetta, R., additional, Bulgari, M., additional, Quinzani, F., additional, Lombardi, C., additional, Bosi, S., additional, Schiavina, G., additional, Squeri, A., additional, Barbieri, A., additional, Di Tano, G., additional, Pirelli, S., additional, Fucili, A., additional, Passero, T., additional, Musio, S., additional, Di Biase, M., additional, Correale, M., additional, Salvemini, G., additional, Brognoli, S., additional, Zanelli, E., additional, Giordano, A., additional, Agostoni, P., additional, Italiano, G., additional, Salvioni, E., additional, Copelli, S., additional, Modena, M.G., additional, Reggianini, L., additional, Valenti, C., additional, Olaru, A., additional, Bandino, S., additional, Deidda, M., additional, Mercuro, G., additional, Cadeddu Dessalvi, C., additional, Marino, P.N., additional, Di Ruocco, M.V., additional, Sartori, C., additional, Piccinino, C., additional, Parrinello, G., additional, Licata, G., additional, Torres, D., additional, Giambanco, S., additional, Busalacchi, S., additional, Arrotti, S., additional, Novo, S., additional, Inciardi, R.M., additional, Pieri, P., additional, Chirco, P.R., additional, Ausilia Galifi, M., additional, Teresi, G., additional, Buccheri, D., additional, Minacapelli, A., additional, Veniani, M., additional, Frisinghelli, A., additional, Priori, S.G., additional, Cattaneo, S., additional, Opasich, C., additional, Gualco, A., additional, Pagliaro, M., additional, Mancone, M., additional, Fedele, F., additional, Cinque, A., additional, Vellini, M., additional, Scarfo, I., additional, Romeo, F., additional, Ferraiuolo, F., additional, Sergi, D., additional, Anselmi, M., additional, Melandri, F., additional, Leci, E., additional, Iori, E., additional, Bovolo, V., additional, Pidello, S., additional, Frea, S., additional, Bergerone, S., additional, Botta, M., additional, Canavosio, F.G., additional, Gaita, F., additional, Merlo, M., additional, Cinquetti, M., additional, Sinagra, G., additional, Ramani, F., additional, Fabris, E., additional, Stolfo, D., additional, Artico, J., additional, Miani, D., additional, Fresco, C., additional, Daneluzzi, C., additional, Proclemer, A., additional, Cicoira, M., additional, Zanolla, L., additional, Marchese, G., additional, Torelli, F., additional, Vassanelli, C., additional, Voronina, N., additional, Tamakauskas, V., additional, Smalinskas, V., additional, Karaliute, R., additional, Petraskiene, I., additional, Kazakauskaite, E., additional, Rumbinaite, E., additional, Vysniauskas, V., additional, Brazyte-Ramanauskiene, R., additional, Petraskiene, D., additional, Stankala, S., additional, Switala, P., additional, Juszczyk, Z., additional, Sinkiewicz, W., additional, Gilewski, W., additional, Pietrzak, J., additional, Orzel, T., additional, Kasztelowicz, P., additional, Kardaszewicz, P., additional, Lazorko-Piega, M., additional, Gabryel, J., additional, Mosakowska, K., additional, Bellwon, J., additional, Rynkiewicz, A., additional, Raczak, G., additional, Lewicka, E., additional, Dabrowska-Kugacka, A., additional, Bartkowiak, R., additional, Sosnowska-Pasiarska, B., additional, Wozakowska-Kaplon, B., additional, Krzeminski, A., additional, Zabojszcz, M., additional, Mirek-Bryniarska, E., additional, Grzegorzko, A., additional, Bury, K., additional, Nessler, J., additional, Zalewski, J., additional, Furman, A., additional, Broncel, M., additional, Poliwczak, A., additional, Bala, A., additional, Zycinski, P., additional, Rudzinska, M., additional, Jankowski, L., additional, Kasprzak, J.D., additional, Michalak, L., additional, Wojtczak Soska, K., additional, Huziuk, I., additional, Retwinski, A., additional, Flis, P., additional, Weglarz, J., additional, Bodys, A., additional, Grajek, S., additional, Kaluzna-Oleksy, M., additional, Straburzynska-Migaj, E., additional, Dankowski, R., additional, Szymanowska, K., additional, Grabia, J., additional, Szyszka, A., additional, Nowicka, A., additional, Samcik, M., additional, Wolniewicz, L., additional, Baczynska, K., additional, Komorowska, K., additional, Poprawa, I., additional, Komorowska, E., additional, Sajnaga, D., additional, Zolbach, A., additional, Dudzik-Plocica, A., additional, Abdulkarim, A.-F., additional, Lauko-Rachocka, A., additional, Kaminski, L., additional, Kostka, A., additional, Cichy, A., additional, Ruszkowski, P., additional, Splawski, M., additional, Fitas, G., additional, Szymczyk, A., additional, Serwicka, A., additional, Fiega, A., additional, Zysko, D., additional, Krysiak, W., additional, Szabowski, S., additional, Skorek, E., additional, Pruszczyk, P., additional, Bienias, P., additional, Ciurzynski, M., additional, Welnicki, M., additional, Mamcarz, A., additional, Folga, A., additional, Zielinski, T., additional, Rywik, T., additional, Leszek, P., additional, Sobieszczanska-Malek, M., additional, Piotrowska, M., additional, Kozar-Kaminska, K., additional, Komuda, K., additional, Wisniewska, J., additional, Tarnowska, A., additional, Balsam, P., additional, Marchel, M., additional, Opolski, G., additional, Kaplon-Cieslicka, A., additional, Gil, R.J., additional, Mozenska, O., additional, Byczkowska, K., additional, Gil, K., additional, Pawlak, A., additional, Michalek, A., additional, Krzesinski, P., additional, Piotrowicz, K., additional, Uzieblo-Zyczkowska, B., additional, Stanczyk, A., additional, Skrobowski, A., additional, Ponikowski, P., additional, Jankowska, E., additional, Rozentryt, P., additional, Polonski, L., additional, Gadula-Gacek, E., additional, Nowalany-Kozielska, E., additional, Kuczaj, A., additional, Kalarus, Z., additional, Szulik, M., additional, Przybylska, K., additional, Klys, J., additional, Prokop-Lewicka, G., additional, Kleinrok, A., additional, Tavares Aguiar, C., additional, Ventosa, A., additional, Pereira, S., additional, Faria, R., additional, Chin, J., additional, De Jesus, I., additional, Santos, R., additional, Silva, P., additional, Moreno, N., additional, Queirós, C., additional, Lourenço, C., additional, Pereira, A., additional, Castro, A., additional, Andrade, A., additional, Oliveira Guimaraes, T., additional, Martins, S., additional, Placido, R., additional, Lima, G., additional, Brito, D., additional, Francisco, A.R., additional, Cardiga, R., additional, Proenca, M., additional, Araujo, I., additional, Marques, F., additional, Moura, B., additional, Leite, S., additional, Campelo, M., additional, Silva-Cardoso, J., additional, Rodrigues, J., additional, Rangel, I., additional, Martins, E., additional, Sofia Correia, A., additional, Peres, M., additional, Marta, L., additional, Ferreira da Silva, G., additional, Severino, D., additional, Durao, D., additional, Leao, S., additional, Magalhaes, P., additional, Moreira, I., additional, Filipa Cordeiro, A., additional, Ferreira, C., additional, Araujo, C., additional, Ferreira, A., additional, Baptista, A., additional, Radoi, M., additional, Bicescu, G., additional, Vinereanu, D., additional, Sinescu, C.-J., additional, Macarie, C., additional, Popescu, R., additional, Daha, I., additional, Dan, G.-A., additional, Stanescu, C., additional, Dan, A., additional, Craiu, E., additional, Nechita, E., additional, Aursulesei, V., additional, Christodorescu, R., additional, Otasevic, P., additional, Simeunovic, D., additional, Ristic, A.D., additional, Celic, V., additional, Pavlovic-Kleut, M., additional, Suzic Lazic, J., additional, Stojcevski, B., additional, Pencic, B., additional, Stevanovic, A., additional, Andric, A., additional, Iric-Cupic, V., additional, Jovic, M., additional, Davidovic, G., additional, Milanov, S., additional, Mitic, V., additional, Atanaskovic, V., additional, Antic, S., additional, Pavlovic, M., additional, Stanojevic, D., additional, Stoickov, V., additional, Ilic, S., additional, Deljanin Ilic, M., additional, Petrovic, D., additional, Stojsic, S., additional, Kecojevic, S., additional, Dodic, S., additional, Cemerlic Adic, N., additional, Cankovic, M., additional, Stojiljkovic, J., additional, Mihajlovic, B., additional, Radin, A., additional, Radovanovic, S., additional, Krotin, M., additional, Klabnik, A., additional, Pernicky, M., additional, Murin, J., additional, Kovar, F., additional, Kmec, J., additional, Semjanova, H., additional, Strasek, M., additional, Savnik Iskra, M., additional, Ravnikar, T., additional, Cernic Suligoj, N., additional, Komel, J., additional, Fras, Z., additional, Jug, B., additional, Glavic, T., additional, Losic, R., additional, Bombek, M., additional, Krajnc, I., additional, Krunic, B., additional, Horvat, S., additional, Kovac, D., additional, Rajtman, D., additional, Cencic, V., additional, Letonja, M., additional, Winkler, R., additional, Valentincic, M., additional, Melihen-Bartolic, C., additional, Bartolic, A., additional, Pusnik Vrckovnik, M., additional, Kladnik, M., additional, Slemenik Pusnik, C., additional, Marolt, A., additional, Klen, J., additional, Drnovsek, B., additional, Leskovar, B., additional, Fernandez Anguita, M.J., additional, Gallego Page, J.C., additional, Salmeron Martinez, F.M., additional, Andres, J., additional, Genis, A.B., additional, Mirabet, S., additional, Mendez, A., additional, Garcia-Cosio, L., additional, Roig, E., additional, Leon, V., additional, Gonzalez-Costello, J., additional, Muntane, G., additional, Garay, A., additional, Alcade-Martinez, V., additional, Lopez Fernandez, S., additional, Rivera-Lopez, R., additional, Puga-Martinez, M., additional, Fernandez-Alvarez, M., additional, Serrano-Martinez, J.L., additional, Grille-Cancela, Z., additional, Marzoa-Rivas, R., additional, Blanco-Canosa, P., additional, Paniagua-Martin, M.J., additional, Barge-Caballero, E., additional, Laynez Cerdena, I., additional, Famara Hernandez Baldomero, I., additional, Lara Padron, A., additional, Ofelia Rosillo, S., additional, Dalmau Gonzalez-Gallarza, R., additional, Salvador Montanes, O., additional, Iniesta Manjavacas, A.M., additional, Castro Conde, A., additional, Araujo, A., additional, Soria, T., additional, Garcia-Pavia, P., additional, Gomez-Bueno, M., additional, Cobo-Marcos, M., additional, Alonso-Pulpon, L., additional, Segovia Cubero, J., additional, Sayago, I., additional, Gonzalez-Segovia, A., additional, Briceno, A., additional, Escribano Subias, P., additional, Vicente Hernandez, M., additional, Ruiz Cano, M.J., additional, Gomez Sanchez, M.A., additional, Barrios Garrido-Lestache, E., additional, Garcia Pinilla, J.M., additional, Garcia de la Villa, B., additional, Sahuquillo, A., additional, Bravo Marques, R., additional, Torres Calvo, F., additional, Perez-Martinez, M.T., additional, Gracia-Rodenas, M.R., additional, Garrido-Bravo, I.P., additional, Pastor-Perez, F., additional, Pascual-Figal, D.A., additional, Diaz Molina, B., additional, Orus, J., additional, Epelde Gonzalo, F., additional, Bertomeu, V., additional, Valero, R., additional, Martinez-Abellan, R., additional, Quiles, J., additional, Rodrigez-Ortega, J.A., additional, Mateo, I., additional, ElAmrani, A., additional, Fernandez-Vivancos, C., additional, Bierge Valero, D., additional, Almenar-Bonet, L., additional, Sanchez-Lazaro, I.J., additional, Marques-Sule, E., additional, Facila-Rubio, L., additional, Perez-Silvestre, J., additional, Garcia-Gonzalez, P., additional, Ridocci-Soriano, F., additional, Garcia-Escriva, D., additional, Pellicer-Cabo, A., additional, de la Fuente Galan, L., additional, Lopez Diaz, J., additional, Recio Platero, A., additional, Arias, J.C., additional, Blasco-Peiro, T., additional, Sanz Julve, M., additional, Sanchez-Insa, E., additional, Aured-Guallar, C., additional, Portoles-Ocampo, A., additional, Melin, M., additional, Hägglund, E., additional, Stenberg, A., additional, Lindahl, I.-M., additional, Asserlund, B., additional, Olsson, L., additional, Afzelius, M., additional, Karlström, P., additional, Tengvall, L., additional, Wiklund, P.-A., additional, Olsson, B., additional, Kalayci, S., additional, Cavusoglu, Y., additional, Gencer, E., additional, Yilmaz, M.B., additional, and Gunes, H., additional

Published
2018
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194. Influence of microstructures and crystalline defects on the superconductivity of MgB[sub 2].

Author

Serquis, A., Liao, X. Z., Zhu, Y. T., Coulter, J. Y., Huang, J. Y., Willis, J. O., Peterson, D. E., Mueller, F. M., Moreno, N. O., Thompson, J. D., Nesterenko, V. F., and Indrakanti, S. S.

Subjects
MAGNESIUM compounds, SUPERCONDUCTIVITY, MICROSTRUCTURE
Abstract

This work studies the influence of microstructures and crystalline defects on the superconductivity of MgB[sub 2], with the objective to improve its flux pinning. A MgB[sub 2] sample pellet that was hot isostatic pressed (HIPed) was found to have significantly increased critical current density (J[sub c]) at higher fields than its un-HIPed counterpart. The HIPed sample had a J[sub c] of 10 000 A/cm² in 50 000 Oe (5 T) at 5 K. This was 20 times higher than that of the un-HIPed sample, and the same as the best J[sub c] reported by other research groups. Microstructures observed in scanning and transmission electron microscopy indicate that the HIP process eliminated porosity present in the MgB[sub 2] pellet resulting in an improved intergrain connectivity. Such improvement in intergrain connectivity was believed to prevent the steep J[sub c] drop with magnetic field H that occurred in the un-HIPed MgB[sub 2] pellet at H >45 000 Oe(4.5 T) and T = 5 K. The HIP process was also found to disperse the MgO that existed at the grain boundaries of the un-HIPed MgB[sub 2] pellet and to generate more dislocations in the pellets. These dispersed MgO particles and dislocations improved flux pinning also at H < 45 000 Oe. The HIPing process was also found to lower the resistivity at room temperature. [ABSTRACT FROM AUTHOR]

Published
2002
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195. Video-assisted thoracic surgery and anatomical lung resections. Where do we stand? National survey by the Spanish Society of Thoracic Surgery

Author

Embun R, Martínez Hernández N, Call S, de Olaiz Navarro B, Zabaleta J, Ramos R, Galbis J, and Moreno N

Subjects
Video-assisted thoracic surgery, Health care surveys, Non-small cell lung carcinoma
Abstract

Introduction: The objective of this survey is to find out the cumulated experience and the current situation of video-assisted thoracic surgery (VATS) for anatomical lung resections in Spain. Methods: This is a descriptive study performed from two independent surveys designed through the Survey Monkey(R)web platform. The first survey was aimed at 53 thoracic surgery departments from the public and state-assisted national health system. The second survey, of a personal nature, was directed at 315 thoracic surgeons in active service, including physicians at their residency program. The surveys were kept operative from 18/11/2014 to 15/01/2015. Results: The first survey was answered by 32 (60%) departments and the second by 167 (53%) professionals. A total of 29 (91%) of the thoracic surgery departments represented recognized having some level of experience in this technique. However, a great proportion of departments, 15 (52%), counted less than 100 procedures and the cumulated time of experience was lower than 5 years in 19 (66%) departments. Among all the individual respondents, 126 (77%) admitted having performed the procedure at some point. Of those without any experience, at least 36 (95%) of them recognized that future training in this technique is one of their future professional objectives. Conclusions: Waiting for future prospective national registries contribute further information about the expansion of this technique in our country, the results of the current survey show, up to now, the best reflection of clinical practice and opinion of the surgeons involved in the development of VATS.(C) 2016 AEC. Published by Elsevier Espana, S.L.U. All rights reserved.

Published
2017

196. Detection of Wolbachia bacteria in multiple organs and feces of the triatomine insect Rhodnius pallescens (Hemiptera, Reduviidae)

Author

Espino, C.I., Gomez, T., Gonzalez, G., do Santos, M. F. Brazil, Solano, J., Sousa, O., Moreno, N., Windsor, D., Ying, A., Vilchez, S., and Osuna, A.

Subjects
Endosymbiosis -- Analysis, Host-bacteria relationships -- Analysis, Trypanosoma -- Genetic aspects, Wolbachia -- Genetic aspects, Biological sciences
Abstract

Many types of Wolbachia bacteria are detected in wild and insectarium-raised Rhodnius pallescens, a natural vector of Trypanosoma cruzi and Trypanosoma rangeli. Wolbachia is detected in all the organs and tissues and in the feces and it has provided a methodological advantage for determining the presence of endosymbiont in this host, thus avoiding the need to kill the specimens.

Published
2009

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