651 results on '"Naccarato, P."'
Search Results
152. Sympathovagal balance and 1-h postload plasma glucose in normoglucose tolerant hypertensive patients
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Perticone, Maria, Tassone, Eliezer J., Scarpino, Paola E., Naccarato, Paola, Addesi, Desirée, di Cello, Serena, Sciacqua, Angela, Maio, Raffaele, Andreucci, Michele, Carrao, Salvatore, Licata, Anna, Sesti, Giorgio, and Perticone, Francesco
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- 2016
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153. Whole brain radiotherapy with hippocampal avoidance and simultaneous integrated boost for brain metastases: a dosimetric volumetric-modulated arc therapy study
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Giaj Levra, Niccolò, Sicignano, Gianluisa, Fiorentino, Alba, Fersino, Sergio, Ricchetti, Francesco, Mazzola, Rosario, Naccarato, Stefania, Ruggieri, Ruggero, and Alongi, Filippo
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- 2016
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154. Association between RAD 51 rs1801320 and susceptibility to glioblastoma
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Franceschi, S., Tomei, S., Mazzanti, C. M., Lessi, F., Aretini, P., La Ferla, M., De Gregorio, V., Pasqualetti, F., Zavaglia, K., Bevilacqua, G., and Naccarato, A. G.
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- 2016
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155. Least Orthogonal Distance Estimator and Total Least Square for Simultaneous Equation Models
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Alessia Naccarato, Davide Zurlo, and Luciano Pieraccini
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Statistics ,HA1-4737 - Abstract
Least Orthogonal Distance Estimator (LODE) of Simultaneous Equation Models’ structural parameters is based on minimizing the orthogonal distance between Reduced Form (RF) and the Structural Form (SF) parameters. In this work we propose a new version – with respect to Pieraccini and Naccarato (2008) – of Full Information (FI) LODE based on decomposition of a new structure of the variance-covariance matrix using Singular Value Decomposition (SVD) instead of Spectral Decomposition (SD). In this context Total Least Square is applied. A simulation experiment to compare the performances of the new version of FI LODE with respect to Three Stage Least Square (3SLS) and Full Information Maximum Likelihood (FIML) is presented. Finally a comparison between the FI LODE new and old version together with few words of conclusion conclude the paper.
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- 2014
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156. Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B
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Simone Pippa, Cecilia Mannironi, Valerio Licursi, Luca Bombardi, Gianni Colotti, Enrico Cundari, Adriano Mollica, Antonio Coluccia, Valentina Naccarato, Giuseppe La Regina, Romano Silvestri, and Rodolfo Negri
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histone demethylase inhibitors ,DNA damage ,epigenetic drugs ,breast cancer ,Organic chemistry ,QD241-441 - Abstract
Background: KDM5 enzymes are H3K4 specific histone demethylases involved in transcriptional regulation and DNA repair. These proteins are overexpressed in different kinds of cancer, including breast, prostate and bladder carcinomas, with positive effects on cancer proliferation and chemoresistance. For these reasons, these enzymes are potential therapeutic targets. Methods: In the present study, we analyzed the effects of three different inhibitors of KDM5 enzymes in MCF-7 breast cancer cells over-expressing one of them, namely KDM5B/JARID1B. In particular we tested H3K4 demethylation (western blot); radio-sensitivity (cytoxicity and clonogenic assays) and damage accumulation (COMET assay and kinetics of H2AX phosphorylation). Results: we show that all three compounds with completely different chemical structures can selectively inhibit KDM5 enzymes and are capable of increasing sensitivity of breast cancer cells to ionizing radiation and radiation-induced damage. Conclusions: These findings confirm the involvement of H3K4 specific demethylases in the response to DNA damage, show a requirement of the catalytic function and suggest new strategies for the therapeutic use of their inhibitors.
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- 2019
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157. On the Meaning and Measurement of Engagement in Youth Residential Treatment Centers
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Cunningham, Wm. Scott, Duffee, David E., Huang, Yufan, Steinke, Camela M., and Naccarato, Toni
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Objective: This study describes the development of an engagement scale for use with youth in residential treatment centers. Engagement includes attitude about treatment, bond with providers, and participation in treatment activities. Method: Interview data were collected at the midpoint in residence of 130 youth in two centers. Items were selected to capture practitioners' description of three related concepts in a logic model. The authors conducted confirmatory factor analysis and examined interitem reliability. Results: Results indicate a single underlying factor, which the authors label engagement, an acceptable level of reliability, and strong content validity. Conclusion: The scale integrates several concepts in the treatment process literature and might serve to assess youth engagement in residential settings. Additional study should examine construct and construct validity. (Contains 6 tables and 2 figures.)
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- 2009
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158. Thunderstorm incidence in southeastern Brazil estimated from different data sources
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O. Pinto Jr., K. P. Naccarato, and I. R. C. A. Pinto
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Science ,Physics ,QC1-999 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
This paper describes a comparative analysis of the thunderstorm incidence in southeastern Brazil obtained from thunderstorm days observed at two different epochs (from 1910 to 1951 and from 1971 to 1984) and from lightning data provided by the Brazilian lightning location system RINDAT (from 1999 to 2006) and the Lightning Imaging Sensor (LIS) on board the Tropical Rainfall Measuring Mission (TRMM) satellite (from 1998 to 2010). The results are interpreted in terms of the main synoptic patterns associated with thunderstorm activity in this region, indicating that the prevailing synoptic pattern associated with thunderstorm activity is the occurrence of frontal systems and their modulation by the South Atlantic Convergence Zone (SACZ) and topography. Evidence of urban effects is also found. The results are also discussed in the context of practical applications involving their use in the Brazilian lightning protection standards, suggesting that the present version of the Brazilian standards should be revised incorporating RINDAT and LIS data. Finally, the results are important to improve our knowledge about the limitations of the different techniques used to record the thunderstorm activity and support future climatic studies.
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- 2013
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159. Avaliação do ventrículo direito pelo ecocardiograma com doppler tecidual na embolia pulmonar aguda
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Ana Clara Tude Rodrigues, Adriana Cordovil, Claudia Monaco, Laise Guimarães, Alexandre Cury, Gustavo A F Naccarato, Edgar Lira-Filho, Claudio Henrique Fischer, Marcelo Luiz Campos Vieira, and Samira Morhy
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Função Ventricular Direita ,Ecocardiografia Doppler ,Embolia Pulmonar ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
FUNDAMENTO: A avaliação da função Ventricular Direita (VD) pelo ecocardiograma em pacientes com Tromboembolismo Pulmonar (TEP) é complexa, frequentemente qualitativa; o Doppler tecidual tem sido utilizado para avaliação semiquantitativa dessa câmara, com algumas limitações. OBJETIVO: Avaliar a função do VD no TEP pelo ecocardiograma com Doppler tecidual, complementando com o peptídeo atrial natriurético (BNP). MÉTODOS: Foram estudados pacientes com TEP pelo ecocardiograma com Doppler tecidual e BNP até 24 horas do diagnóstico, obtendo-se as velocidades miocárdicas (s'), strain, strain rate e índice de performance miocárdica do VD; disfunção do VD foi iagnosticada por hipocinesia da câmara, movimento anormal septal e relação VD/VE >1. De acordo com o BNP os pacientes foram divididos em Grupo I, BNP < 50 pg/mL e Grupo II, BNP > 50 pg/mL. RESULTADOS: De 118 pacientes, 100 (60 homens, idade = 55 ± 17 anos) foram analisados; observou-se disfunção do VD em 28%, mais frequentemente no grupo II (19 vs. 9 pacientes, p < 0,001). O grupo II era mais idoso (64 ± 19 vs. 50 ± 15 anos), apresentava menor velocidade de s' (10,5 ± 3,5 vs. 13,2 ± 3,1 cm/s) e maior pressão pulmonar (48 ± 11 vs. 35 ± 11 mmHg), p < 0,001 para todos. O ponto de corte de s' para disfunção do VD foi de 10,8 cm/s (especificidade = 85%, sensibilidade = 54%), com moderada correlação entre o BNP e a onda s'(r = -0,39). CONCLUSÃO: No TEP, a disfunção do VD pelo ecocardiograma se acompanha de elevação do BNP; apesar confirmar adequadamente a presença de disfunção do VD, o Doppler tecidual apresenta sensibilidade limitada para este diagnóstico.
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- 2013
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160. Least orthogonal distance estimator of structural parameters in simultaneous equation models
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Luciano Pieraccini and Alessia Naccarato
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Statistics ,HA1-4737 - Abstract
The aim of this paper is to present a consistent estimator of parameters in simultaneous equation model, based on characteristic roots and vectors of a matrix derived from the so called over-identifying restrictions. The Least Orthogonal Distance Estimator presented here is a more recent development of its original limited information version. The occasion, for reviewing it, has been given by its extension to a full information context which is here completely formalized and by the very encouraging results of recent simulation experiments.
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- 2013
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161. Immunohistochemical markers of neural progenitor cells in the early embryonic human cerebral cortex
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L. Vinci, A. Ravarino, V. Fanos, A.G. Naccarato, G. Senes, C. Gerosa, G. Bevilacqua, G. Faa, and R. Ambu
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Cerebral cortex ,human embryo ,human development ,immunohistochemistry ,fetal stem cells. ,Biology (General) ,QH301-705.5 - Abstract
The development of the human central nervous system represents a delicate moment of embryogenesis. The purpose of this study was to analyze the expression of multiple immunohistochemical markers in the stem/progenitor cells in the human cerebral cortex during the early phases of development. To this end, samples from cerebral cortex were obtained from 4 human embryos of 11 weeks of gestation. Each sample was formalin-fixed, paraffin embedded and immunostained with several markers including GFAP, WT1, Nestin, Vimentin, CD117, S100B, Sox2, PAX2, PAX5, Tβ4, Neurofilament, CD44, CD133, Synaptophysin and Cyclin D1. Our study shows the ability of the different immunohistochemical markers to evidence different zones of the developing human cerebral cortex, allowing the identification of the multiple stages of differentiation of neuronal and glial precursors. Three important markers of radial glial cells are evidenced in this early gestational age: Vimentin, Nestin and WT1. Sox2 was expressed by the stem/progenitor cells of the ventricular zone, whereas the postmitotic neurons of the cortical plate were immunostained by PAX2 and NSE. Future studies are needed to test other important stem/progenitor cells markers and to better analyze differences in the immunohistochemical expression of these markers during gestation.
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- 2016
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162. Metronomic Ceramide Analogs Inhibit Angiogenesis in Pancreatic Cancer through Up-regulation of Caveolin-1 and Thrombospondin-1 and Down-regulation of Cyclin D1
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Guido Bocci, Anna Fioravanti, Paola Orlandi, Teresa Di Desidero, Gianfranco Natale, Giovanni Fanelli, Paolo Viacava, Antonio Giuseppe^Naccarato, Giulio Francia, and Romano Danesi
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
AIMS: To evaluate the antitumor and antiangiogenic activity of metronomic ceramide analogs and their relevant molecular mechanisms. METHODS: Human endothelial cells [human dermal microvascular endothelial cells and human umbilical vascular endothelial cell (HUVEC)] and pancreatic cancer cells (Capan-1 and MIA PaCa-2) were treated with the ceramide analogs (C2, AL6, C6, and C8), at low concentrations for 144 hours to evaluate any antiproliferative and proapoptotic effects and inhibition of migration and to measure the expression of caveolin-1 (CAV-1) and thrombospondin-1 (TSP-1) mRNAs by real-time reverse transcription-polymerase chain reaction. Assessment of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and Akt phosphorylation and of CAV-1 and cyclin D1 protein expression was performed by ELISA. Maximum tolerated dose (MTD) gemcitabine was compared against metronomic doses of the ceramide analogs by evaluating the inhibition of MIA PaCa-2 subcutaneous tumor growth in nude mice. RESULTS: Metronomic ceramide analogs preferentially inhibited cell proliferation and enhanced apoptosis in endothelial cells. Low concentrations of AL6 and C2 caused a significant inhibition of HUVEC migration. ERK1/2 and Akt phosphorylation were significantly decreased after metronomic ceramide analog treatment. Such treatment caused the overexpression of CAV-1 and TSP-1 mRNAs and proteins in endothelial cells, whereas cyclin D1 protein levels were reduced. The antiangiogenic and antitumor impact in vivo of metronomic C2 and AL6 regimens was similar to that caused by MTD gemcitabine. CONCLUSIONS: Metronomic C2 and AL6 analogs have antitumor and antiangiogenic activity, determining the up-regulation of CAV-1 and TSP-1 and the suppression of cyclin D1.
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- 2012
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163. Lightning risk warnings based on atmospheric electric field measurements in Brazil
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Marco Antonio da Silva Ferro, Jorge Yamasaki, Douglas Roberto M. Pimentel, Kleber Pinheiro Naccarato, and Marcelo Magalhães Fares Saba
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Atmospheric electric field ,Electric field-mill ,Lightning ,Technology ,Motor vehicles. Aeronautics. Astronautics ,TL1-4050 - Abstract
This paper presents a methodology that employs the electrostatic field variations caused by thundercloud formation or displacement to generate lightning warnings over a region of interest in Southeastern Brazil. These warnings can be used to prevent accidents during hazardous operations, such as the manufacturing, loading, and test of motor-rockets. In these cases, certain equipment may be moved into covered facilities and personnel are required to take shelter. It is also possible to avoid the threat of natural and triggered lightning to launches. The atmospheric electric field database, including the summer seasons of 2007/2008 and 2008/2009 (from November to February), and, for the same period and region, the cloud-to-ground lightning data provided by the Brazilian lightning detection network – BrasilDAT – were used in order to perform a comparative analysis between the lightning warnings and the cloud-to- ground lightning strikes that effectively occurred inside the area of concern. The analysis was done for three areas surrounding the sensor installation defined as circles with 5, 10 and 15 km of radius to determine the most effective detection range. For each area it was done using several critical electric field thresholds: +/- 0.5; +/- 0.8; +/- 0.9; +/- 1.0; +/- 1.2; and +/- 1.5 kV/m. As a result of the reduction of atmospheric electric field data provided by the sensor installed in area of concern and lightning provided by BrasilDAT, it was possible, for each of the areas of alert proposals, to obtain the following parameters: the number of effective alarms; the number of false alarms; and the number of failure to warning. From the analysis of these parameters, it was possible to conclude that, apparently, the most interesting critical electric field threshold to be used is the level of 0.9 kV/m in association with a distance range of 10 km around the point where the sensor is installed.
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- 2011
164. I Diretriz da Sociedade Brasileira de Cardiologia sobre processos e competências para a formação em cardiologia no Brasil
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MR de Sousa, GS Feitosa, AAV de Paola, JC Schneider, GS Feitosa-Filho, JC Nicolau, JFM Ferreira, RCM de Carvalho, WA Chalela, MVB Malachias, JLB Pena, F Somaio-Neto, MW Montera, GV Barbosa, F Bacal, IB Jatene, RD Santos, RD Miranda, JM Peixoto, MR Barbosa, G Fenelon, AH Assef, AFP Naccarato, CRM Rodrigues Sobrinho, I Kohler, JNG de Vasconcelos, MJG Magalhães, NS de Morais, RM Rocha, RRCV Giraldez, and GC da Silva
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2011
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165. Relation between three-dimensional and two-dimensional echocardiography and biochemical analysis in patients with ST-segment elevation myocardial infarction percutaneously treated
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Marcelo Luiz Campos Vieira, Wercules Antônio Oliveira, Alexandre Ferreira Cury, Adriana Cordovil, Ana Clara Tude Rodrigues, Gustavo Alberto Frazatto Naccarato, Claudia Gianini Monaco, Lea Paula Ravani Beneti Costa, Renata Barbara Romano, João Roberto Calatroia, Tania Regina Afonso, Glaucia Maria Penha Tavares, Laise Antônia Bonfim Guimarães, Edgar Bezerra Lira Filho, Marco Antonio Perin, Claudio Henrique Fischer, and Samira Saady Morhy
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Infarction ,Myocardial infarction ,Myocardial infarction/metabolism ,Myocardial infarction/ultrasonography ,Biochemistry/instrumentation ,Biochemical reactions ,Echocardiography ,Echocardiography/instrumentation ,Echocardiography, three-dimensional/methods ,Biological markers ,Administration, cutaneous ,Coronary disease/therapy ,Medicine - Abstract
ABSTRACT Objective: The prognosis of patients with acute myocardial infarction depends on multiple features that can demonstrate myocardial injury degree (such as serum markers of cardiac necrosis), and also on adaptive mechanisms relative to the acute event. The aim of the study was to assess the relation between biochemical and echocardiographic findings from three-dimensional echocardiographic (3D Echo) analysis and echocardiographic two-dimensional (2D Echo) left ventricular ejection fraction in patients with ST-segment elevation acute myocardial infarction, submitted to primary percutaneous treatment. Methods: A prospective study with 2D Echo and 3D Echo of 23 patients (17 males, mean age of 57 ± 13 years) with ST-segment elevation acute myocardial infarction, primarily percutaneously treated (stent). Serum cardiac markers (creatine kinase MB, Troponin I and Myoglobin) and serum brain natriuretic peptide were compared to echocardiographic parameters (volumes, left ventricular ejection fraction and ventricular dyssynchrony index). The statistical analysis was performed using Pearson's correlation coefficient, 95% CI, p < 0.05, linear regression equation and Bland & Altman test. Results: Pearson's correlation coefficient (r)relative to 3D left ventricular ejection fraction: 1- brain natriuretic peptide: r: - 0.7427, p < 0.0001; 2- creatine kinase MB: r: - 0.660, p = 0.001. Left ventricular ejection fraction 2D (r) : 1- brain natriuretic peptide: r: - 0.5478, p = 0.001; 2- creatine kinase MB: r: - 0.4800, p < 0.0277. Other associations were not significant. Conclusions: In this series, it was observed better correlation in regard to serum creatine kinase MB, brain natriuretic peptide and 3D Echo left ventricular ejection fraction, when compared to 2D Echo left ventricular ejection fraction.
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- 2010
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166. Uterine fundus indocyanine green injection for sentinel lymph node biopsy in endometrial cancer patients with limited access to cervical injection.
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Bizzarri, Nicolò, Parisi, Giuseppe, Di Berardino, Stefano, Naccarato, Laura, Scambia, Giovanni, and Fanfani, Francesco
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- 2024
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167. Inter-Comparison of Carbon Content in PM2.5 and PM10 Collected at Five Measurement Sites in Southern Italy
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Adelaide Dinoi, Daniela Cesari, Angela Marinoni, Paolo Bonasoni, Angelo Riccio, Elena Chianese, Giuseppina Tirimberio, Attilio Naccarato, Francesca Sprovieri, Virginia Andreoli, Sacha Moretti, Daniel Gullì, Claudia R. Calidonna, Ivano Ammoscato, and Daniele Contini
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particulate matter ,carbonaceous fraction ,organic carbon ,elemental carbon ,SOC ,Meteorology. Climatology ,QC851-999 - Abstract
A field campaign was performed simultaneously at five measurement sites, having different characteristics, to characterize the spatial distribution of the carbonaceous content in atmospheric aerosol in Southern Italy during the winter season. Organic carbon (OC) and elemental carbon (EC) were measured at urban (Naples), suburban (Lecce), coastal/marine (Lamezia Terme and Capo Granitola), and remote (Monte Curcio) locations. OC and EC mass concentrations were quantified by the thermal-optical transmission (TOT) method, in 24-h PM10 and PM2.5 samples collected on quartz fiber filters, from 25 November 2015 to 1 January 2016. The different sites showed marked differences in the average concentrations of both carbonaceous species. Typically, OC average levels (±standard deviation) were higher at the sites of Naples (12.8 ± 5.1 and 11.8 ± 4.6 μg/m3) and Lecce (10.7 ± 5.8 and 9.0 ± 4.7 μg/m3), followed by Lamezia Terme (4.3 ± 2.0 and 4.0 ± 1.9 μg/m3), Capo Granitola (2.3 ± 1.2 and 1.7 ± 1.1 μg/m3), and Monte Curcio (0.9 ± 0.3 and 0.9 ± 0.3 μg/m3) in PM10 and PM2.5, respectively. Similarly, EC average levels (±standard deviation) were higher at the urban sites of Naples (2.3 ± 1.1 and 1.8 ± 0.5 μg/m3) and Lecce (1.5 ± 0.8 and 1.4 ± 0.7 μg/m3), followed by Lamezia Terme (0.6 ± 0.3 and 0.6 ± 0.3 μg/m3), Capo Granitola (0.3 ± 0.3 and 0.3 ± 0.2 μg/m3), and Monte Curcio (0.06 ± 0.04 and 0.05 ± 0.03 μg/m3) in PM10 and PM2.5, respectively. An opposite trend was observed for the OC/EC ratios ranging from 6.4 to 15.9 in PM10 and from 6.4 to 15.5 in PM2.5 with lower values in urban sites compared to remote sites. Different OC-EC correlations, 0.36 < R2 < 0.90, were found in four observation sites. This behavior suggests the contributions of similar sources and common atmospheric processes in both fractions. No correlations were observed between OC and EC at the site of Naples. The average secondary organic carbon (SOC) concentrations, quantified using the minimum OC/EC ratio method, ranged from 0.4 to 7.6 μg/m3 in PM10 and from 0.4 to 7.2 μg/m3 in PM2.5, accounting from 37 to 59% of total OC in PM10 and from 40 to 57% in PM2.5 with higher percentages in the urban and suburban sites of Naples and Lecce.
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- 2017
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168. Segurança da ecocardiografia transesofágica em adultos: estudo em um hospital multidisciplinar Seguridad de la ecocardiografía transesofágica en adultos: estudio en un hospital multidisciplinario Safety of transesophageal echocardiography in adults: study in a multidisciplinary hospital
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Alexandre Ferreira Cury, Marcelo Luiz Campos Vieira, Claudio Henrique Fischer, Ana Clara Tude Rodrigues, Adriana Cordovil, Claudia Monaco, Gustavo Alberto Naccarato, Glaucia Tavares, Edgar Bezerra Lira Filho, Laise Antonia Guimarães, and Samira Saady Morhy
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Ecocardiografía transesofágica ,seguridad ,midazolam ,flumazenil ,Ecocardiografia Transesofágica ,Segurança ,Midazolam ,Flumazenil ,Echocardiography, Transesophageal ,Safety ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
FUNDAMENTO: A ecocardiografia transesofágica (ETE) é um exame semi-invasivo amplamente utilizado e seu uso associado a sedativos poderá influenciar a segurança do procedimento. OBJETIVO: analisar aspectos da segurança da ETE associada ao uso de midazolam (MZ) e flumazenil (FL) e a influência de variáveis clínicas na taxa de eventos. MÉTODO: estudo prospectivo com 137 pacientes que realizaram ETE com MZ associado à sedação moderada. Analisamos as seguintes ocorrências: complicações com anestesia tópica, ao uso do MZ e complicações relacionadas ao procedimento. Análises uni e multivariada foram usadas para testar a influência das variáveis clínicas: idade, sexo, acidente vascular cerebral (AVC), miocardiopatia (MP), duração do exame, insuficiência mitral (IM) e dose de MZ. RESULTADOS: todos pacientes (65±16 anos; 58% masculino) completaram o exame. As doses médias de MZ e FL foram de 4,3±1,9 mg e 0,28±0,2 mg, respectivamente. A duração do exame e a fração de ejeção (FE) média foram de 16.4±6.1 minutos e 60±9%, respectivamente. O evento mais comum foi a hipóxia leve (SO25mg) tiveram associação com tais eventos (pFUNDAMENTO: La ecocardiografía transesofágica (ETE) es un examen semiinvasivo ampliamente utilizado y su uso asociado a sedantes puede influir sobre la seguridad del procedimiento. OBJETIVO: Analizar aspectos de la seguridad de la ETE asociada al uso de midazolam (MZ) y flumazenil (FL) y la influencia de variables clínicas en la tasa de complicaciones. MÉTODO: Estudio prospectivo con 137 pacientes, a quienes se realizó ETE con MZ asociado a la sedación moderada. Analizamos los siguientes eventos: complicaciones con anestesia local, relacionadas al uso de MZ y complicaciones relacionadas con el procedimiento. Se utilizaron análisis uni y multivariados para evaluar la influencia de las variables clínicas: edad, sexo, accidente cerebrovascular (ACV), miocardiopatía (MP), duración del estudio, insuficiencia mitral (IM) y dosis de MZ. RESULTADOS: Todos los pacientes (65±16 años; 58% masculino) completaron el estudio. Las dosis promedio de MZ y FL fueron de 4,3±1,9 mg y 0,28±0,2 mg, respectivamente. La duración del estudio y la fracción de eyección (FE) promedio fueron de 16.4±6.1 minutos y 60±9%, respectivamente. El evento más común fue la hipoxia leve (SO25mg) se asociaron a tales complicaciones (pBACKGROUND: TEE is a semi-invasive tool broadly used and its utilization associated to sedatives drugs might to affect the procedure safety. OBJECTIVE: to analyze aspects of TEE safety associated to the use of Midazolan (MZ) and Flumazenil (FL) and the influence of the clinical variables on the event rate. METHOD: prospective study with 137 patients that underwent TEE with MZ associated to moderate sedation. We analyzed the following events: complications related with the topical anesthesia, with MZ use and with the procedure. Uni- and multivariate analyses were used to test the influence of the clinical variables: age, sex, stroke, myocardiopathy (MP), duration of the test, mitral regurgitation (MR) and the MZ dose. RESULTS: All patients (65±16 yrs; 58% males) finished the examination. The mean doses of MZ and FL were 4.3±1.9 mg and 0.28±0.2 mg, respectively. The duration of the examination and the mean ejection fraction (EF) were 16.4±6.1 minutes and 60±9%, respectively. Mild hypoxia (SO25mg) were associated with events (p
- Published
- 2009
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169. Fração de ejeção e volumes do ventrículo esquerdo medidos com eco 3D e com tomografia ultra-rápida Fracción de eyección y volúmenes del ventrículo izquierdo medidos con eco- 3DTR y con tomografía ultrarrápida Left ventricular ejection fraction and volumes as measured by 3d echocardiography and ultrafast computed tomography
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Marcelo Luiz Campos Vieira, César H. Nomura, Bernardino Tranchesi Junior, Wercules A. de Oliveira, Gustavo Naccarato, Bruna S. Serpa, Rodrigo B. D. Passos, Marcelo B. G. Funari, Cláudio H. Fischer, and Samira S. Morhy
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Ecocardiografía tridimensional ,tomografía computarizada por emisión ,corazón ,volumen sistólico ,Ecocardiografia tridimensional ,tomografia computadorizada por emissão ,coração ,volume sistólico ,Echocardiography ,three-dimensional ,tomography ,emission-computed ,heart ,stroke volume ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
FUNDAMENTO: O ecocardiograma tridimensional em tempo real (ECO 3D) e a tomografia computadorizada ultra-rápida (CT) são dois novos métodos de análise da fração de ejeção e dos volumes do VE. OBJETIVO: Comparar as medidas da FEVE e dos volumes do VE aferidos pelo ECO 3D e pela CT ultra-rápida. MÉTODOS: Foram estudados pelo ECO 3D e pela CT ultra-rápida de 64 cortes, 39 pacientes consecutivos (27 homens, média etária de 57±12 anos). Foram analisados: FEVE e volumes do VE. Análise estatística: coeficiente de correlação (r: Pearson), teste de Bland & Altman, teste de regressão linear, 95 % IC, pFUNDAMENTO: La ecocardiografía tridimensional en tiempo real (Eco-3DTR) y la tomografía computarizada ultrarrápida (TC ultrarrápida) son dos nuevos métodos de análisis de la fracción de eyección (FE) y de los volúmenes del ventrículo izquierdo (VI). OBJETIVO: Comparar las mediciones de la fracción de eyección del ventrículo izquierdo (FEVI) y de los volúmenes del VI apurados por la Eco-3DTR y por la TC ultrarrápida. MÉTODOS: Se estudiaron, mediante la Eco-3DTR y la TC ultrarrápida de 64 cortes, a 39 pacientes consecutivos (27 varones, promedio de edad de 57±12 años). Se analizaron: FEVI y volúmenes del VI. Análisis estadístico: coeficiente de correlación (r: Pearson), prueba de Bland & Altman, prueba de regresión lineal, 95 % IC, pBACKGROUND: Real-time three-dimensional echocargiography (RT-3D-Echo) and ultrafast computed tomography (CT) are two novel methods for the analysis of LV ejection fraction and volumes. OBJECTIVE: To compare LVEF and volume measurements as obtained using RT-3D-Echo and ultrafast CT. METHODS: Thirty nine consecutive patients (27 men, mean age of 57±12 years) were studied using RT-3D-Echo and 64-slice ultrafast CT. LVEF and LV volumes were analyzed. Statistical analysis: coefficient of correlation (r: Pearson), Bland-Altman analysis, linear regression analysis, 95% CI, p
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- 2009
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170. Student Ratings Halo Effect Reduction by Alteration of Standard Instructions. 76-18. Educational Assessment Center Project: 554.
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Washington Univ., Seattle. Educational Assessment Center. and Naccarato, Richard W.
- Abstract
The purpose of this study was to determine if correlations among student ratings items designed to be diagnostic could be lowered through use of special instructions to raters. The authors argue that the lowering of inter-item correlations is indicative of a reduction of the halo effect which leads to greater item diagnosticity. The experimental group first ranked items in terms of importance, then rated the course with the diagnostic items, then rated the course with the general items. This order was reversed for the control group. The correlations among items were significantly lower for the experimental group. (Author)
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- 1976
171. The Effect of Factors Outside the Instructor's Control on Student Ratings of Instruction.
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Washington Univ., Seattle. Educational Assessment Center., Gillmore, Gerald M., and Naccarato, Richard W.
- Abstract
This study assessed the effect of factors outside the instructor's control on student ratings of instruction. Seven special items along with the standard Student Ratings forms were administered to 28 classes in the Anthropology Department. Results indicated that the impact of outside factors, as perceived by students, was not correlated with global evaluative ratings. (Author/RC)
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- 1975
172. The Application of Generalizability Theory to a College-Level French Placement Exam.
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Washington Univ., Seattle. Educational Assessment Center., Naccarato, Richard W., and Gillmore, Gerald M.
- Abstract
This paper involves an application of generalizability theory in assessing the dependability of a foreign language placement exam. The French Cloze test was administered to students within five levels of French classes and the results were scored by four different raters. Three specific generalizability coefficients are discussed along with implications of imposing three additional restrictions on the method by which future data are collected. The results show a very high item and student by item variance component and little variance due to the rater component. For this study adequate generalizability of students' scores was obtained for all generalizability coefficients using half of the total number of items on the exam and only one rater. Results indicate that in future decision studies involving tests of this nature each student should repond to the same set of items. Also, sufficient reliability may be obtained using only one rater per student but not all students need be rated by the same rater. (Author)
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- 1976
173. A Guide to Item Banking in Education. (Third Edition).
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Northwest Regional Educational Lab., Portland, OR. Center for Performance Assessment. and Naccarato, Richard W.
- Abstract
The current status of banks of test items existing across the United States was determined through a survey conducted between September and December 1987. Item "bank" in this context does not imply that the test items are available in computerized form, but simply that "deposited" test items can be withdrawn for use. Emphasis was on documenting the sources of test items in the various subject areas that respondents considered to measure higher order thinking skills. Complete copies of the 41 Item Bank Data Sheets that were returned are included to describe item banks maintained by state or regional agencies (46% of the respondents), commercial ventures (33%), and school districts (20%). Most item collections contain basic skills items for reading, language arts, and math, but many are branching into science and the social sciences. Progress made in item banking in the last few years appears likely to increase with the development of better hardware and software. (SLD)
- Published
- 1988
174. Assessing Learning Motivation: A Consumer's Guide.
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Northwest Regional Educational Lab., Portland, OR. and Naccarato, Richard W.
- Abstract
Guidelines for use by school practitioners in assessing students' motivation to learn are presented. Most of the instruments reviewed and literature discussed pertain primarily to the academic motivation and achievement of students in kindergarten through grade 12. Most are paper-and-pencil, self-report, group-administered measures that can be given within an hour. Definitions of basic concepts, current issues for assessing motivation, and thoughts on the future of assessment of motivation are presented. Lengthy reviews of certain selected instruments are presented, along with shorter reviews of related instruments and criteria for selecting appropriate measures of motivation. The guide is designed to provide users with enough of a conceptual overview of motivation and an awareness of existing instruments to proceed in their own review and selection more efficiently and systematically. Appendices include reviews of motivation measures, multidimensional measures, and motivation-related measures; a checklist for selecting a motivation instrument; and lists of testing resources and pertinent bibliographies. (TJH)
- Published
- 1988
175. Three-dimensional echocardiographic analysis of electromechanical synchrony: comparison with three-dimensional and two-dimensional ejection fraction for evaluation of left ventricular systolic performance
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Marcelo Luiz Campos Vieira, Alexandre Ferreira Cury, Gustavo Alberto Frazatto Naccarato, Wercules Antonio Alves de Oliveira, Adriana Cordovil, Ana Clara Tude Rodrigues, Claudia Gianini Monaco, Edgar Bezerra Lira Filho, Glaucia Maria Penha Tavares, Abraham Pfeferman, Marcia Regina Pinho Makdisse, Claudio Henrique Fischer, and Samira Saady Morhy
- Subjects
Echocardiography ,three-dimensional ,Ventricular function ,Systole ,Medicine - Abstract
Objective: To compare the three-dimensional echocardiographic analysisof left ventricular (LV) synchrony to LV ejection fraction (LVEF) as measuredby two-dimensional (2D) and three-dimensional (3D) echocardiography(ECHO). Methods: This is a prospective study of 71 patients (41 males,aged 49 ± 11 years), 40 of whom with normal cardiac anatomy (ECHO) andelectrocardiography (ECG) (Group N), and 31 with dilated cardiomyopathy(Group DCM). LVEF, volumes and 16-segment dyssynchrony index % (DI)were measured using 3D-ECHO. LVEF (Simpson’s rule) and volumes weremeasured using 2D-ECHO. Data were compared using Pearson correlationcoefficient (r), 95% CI, linear regression equation and Bland-Altman analysis,p < 0.05. Results: DI% ranged from 0.32 to 21.7% (5.94 ± 6.46), 3D LVEFfrom 0.16 to 0.73 (0.51 ± 0.15); and 2D LVEF from 0.2 to 0.7 (0.47 ± 0.17).The correlation coefficient (r) for DI and 3D LVEF was (r): -0.8203, p
- Published
- 2008
176. Índice de dissincronia ventricular: comparação com a fração de ejeção bidimensional e tridimensional Ventricular dyssynchrony index: comparison with two-dimensional and three-dimensional ejection fraction
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Marcelo L. C. Vieira, Alexandre F. Cury, Naccarato Gustavo, Wercules A. Oliveira, Cláudia G. Monaco, Adriana Cordovil, Ana C. T. Rodrigues, Edgar B. Lira Filho, Cláudio H. Fischer, and Samira S. Morhy
- Subjects
Função ventricular esquerda ,sístole ,ecocardiografia ,volume sistólico ,Ventricular function ,left ,systole ,echocardiography ,stroke volume ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
FUNDAMENTO: O acoplamento eletromecânico (sincronia) do ventrículo esquerdo (VE) tem importância na análise da performance sistólica, especialmente para a indicação da terapia de ressincronização cardíaca em pacientes com ICC avançada. OBJETIVO: Comparar a sincronia do VE analisada com ecocardiograma (eco) tridimensional (3D) em tempo real com medidas de FEVE obtidas com ECO 2D e 3D. MÉTODOS: Estudo prospectivo de 92 indivíduos (56 homens, 47±10 anos), 60 com anatomia cardíaca (eco) e ECG normais (Grupo N), 32 com cardiomiopatia dilatada (Grupo CMD). Com o emprego do ECO 3D foram aferidos FEVE, volumes e índice de dissincronia (ID)% para 16 segmentos do VE; com o ECO 2D foram medidos FEVE (método de Simpson) e volumes sistólico e diastólico do VE. Análise estatística: coeficiente de correlação (Pearson), 95% IC, teste de regressão linear, teste de Bland & Altman, pBACKGORUND: Left ventricular (LV) electromechanical coupling (synchrony) is important in the analysis of the systolic performance, especially for the indication of cardiac resynchronization therapy in patients with advanced CHF. OBJECTIVE: To compare LV synchrony as analyzed by real-time three-dimensional (3D) echocardiography (ECHO) with LVEF measurements as obtained with 2D and 3D ECHO. METHODS: Prospective study of 92 individuals (56 men, 47 ± 10 years of age), of which 60 had normal heart structure (ECHO) and ECG (N group), and 32 had dilated cardiomyopathy (DCM group). Using 3D ECHO, LVEF, volumes and dyssynchrony index (%DI) for 16 LV segments were measured. Using 2D ECHO, LVEF (Simpson's method), and LV systolic and diastolic volumes were measured. Statistical analysis: Pearson's correlation coefficient, 95% CI, linear regression model, Bland & Altman analysis, p
- Published
- 2008
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177. Left ventricular synchrony assessment: a comparative analysis using real time three-dimensional echocardiography and tissue Doppler imaging
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Marcelo Luiz Campos Vieira, Alexandre Ferreira Cury, Gláucia Maria Penha Tavares, Edgar Bezerra Lira Filho, Adriana Cordovil, Ana Clara Tude Rodrigues, Cláudia Gianini Mônaco, Gustavo Naccarato, Cláudio Henrique Fischer, and Samira Saady Morhy
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Ventricular function ,Echocardiography ,three-dimensional ,doppler/methods ,Medicine - Abstract
Objective: Left ventricular regional synchrony can be analyzed bythree-dimensional echocardiography (3D Echo) as well as by tissueDoppler imaging (TDI). The aim of the study was to compare leftventricular synchrony assessment by both methods. Methods: Aprospective study of 59 patients (36 males, mean age of 50 years ±11 years), 39 with normal cardiac anatomy and eletrocardiography(group 1), and 20 with dilated cardiomyopathy and wide QRS (group 2).Patients underwent 3D echocardiographic – quantification of ejectionfraction (LVEF), volumes and percentage dyssynchrony index (DI)of left ventricular 6, 12 and 16 segments. By TDI we measured leftventricular QS electromechanical interval in the basal segment of themitral valve annulus of the septum, lateral, anterior and inferior walls,as well as tissue dyssynchrony index (%). The statistical analysis wasperformed using Pearson’s correlation coefficient, 95% CI, p < 0.05,linear regression equation and Bland and Altman test. Results: In thenormal group, the correlation coefficient (r) for TDI DI and 3D 6 DIwas 0.5142, p = 0.001; for 3D 12 DI, r = 0.4110, p = 0.009, and for3D 16 DI, r = 0.3761, p = 0.018. In the dilated group, the correlationcoefficient (r) for TDI DI and 3D 6 DI was 0.3920, p = 0.047; for 3D 12DI, r = 0.1344, p = 0.572; and for 3D 16 DI, r = 0.1105, p = 0.643.Conclusion: In both groups, a poor correlation was observed in leftventricular synchrony assessment by 3D Echo and Tissue Doppler.
- Published
- 2007
178. An in vitro comparison of the force decay generated by different commercially available elastomeric chains and NiTi closed coil springs Comparação in vitro da degradação da força gerada por cadeias elastoméricas e por molas fechadas de NiTi de diferentes marcas comerciais
- Author
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Ana Cristina Soares Santos, André Tortamano, Sandra Regina Frazatto Naccarato, Gladys Cristina Dominguez-Rodriguez, and Julio Wilson Vigorito
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Ortodontia corretiva ,Desenho de aparelho ortodôntico ,Orthodontics, corrective ,Orthodontic appliance design ,Dentistry ,RK1-715 - Abstract
This in vitro study was designed to compare the forces generated by commercially available elastomeric chains and NiTi closed coil springs, and to determine their force decay pattern. Forty elastomeric chains and forty NiTi closed coil springs were divided into 4 groups according to the following manufacturers: (1) Morelli®, (2) Abzil®, (3) TP Orthodontics® and (4) American Orthodontics®. The specimens were extended to twice their original length and stored in artificial saliva at 37°C. Initial force was measured by means of an Instron universal testing machine and then at 1, 4, 7, 14, 21, and 28 days. The results revealed that the elastomeric chains delivered a mean initial force of 347 g for Morelli®, 351 g for American Orthodontics®, 402 g for Abzil®, and 404 g for TP Orthodontics®. The NiTi closed coil springs generated a mean initial force of 196 g for American Orthodontics®, 208 g for TP Orthodontics®, 216 g for Abzil®, and 223 g for Morelli®. The mean percentage of force decay observed after 28 days for the elastomeric chains was 37.4% for TP Orthodontics®, 48.1% for American Orthodontics®, 65.4% for Morelli®, and 71.6% for Abzil®. After 28 days, the NiTi closed coil springs presented a mean percentage of force decay of 22.6% for American Orthodontics®, 29.8% for Abzil®, 30.6% for Morelli®, and 45.8% for TP Orthodontics®. At the end of the study, significant differences were observed between the elastomeric chains and the NiTi closed coil springs. The results indicated that the studied NiTi closed coil springs are more adequate for dental movement than the elastomeric chains.Este estudo in vitro foi delineado para comparar a força gerada por cadeias elastoméricas e por molas fechadas de NiTi comercialmente disponíveis e para determinar seu padrão de degradação de forças. Para tal, 40 segmentos de cadeia elastomérica e 40 molas fechadas de NiTi foram divididas em 4 grupos de acordo com a marca comercial: (1) Morelli®, (2) Abzil®, (3) TP Orthodontics® e (4) American Orthodontics®. As amostras foram distendidas ao dobro de seu comprimento original e imersas em solução de saliva artificial a 37°C. Uma máquina de ensaio (Instron) foi utilizada para aferir a força inicial e em 1, 4, 7, 14, 21 e 28 dias. Os resultados mostraram que as cadeias elastoméricas liberaram uma força média inicial de 404 g para a marca TP Orthodontics®, 402 g para Abzil®, 351 g para American Orthodontics® e 347 g para Morelli®. As molas fechadas de NiTi geraram uma força média inicial de 223 g para a marca Morelli®, 216 g para Abzil®, 208 g para TP Orthodontics® e 196 g para American Orthodontics®. A percentagem média de degradação da força após 28 dias para as cadeias elastoméricas foi de 37,4% para TP Orthodontics®, 48,1% para American Orthodontics®, 65,4% para Morelli® e 71,6% para Abzil®. A percentagem média de degradação da força após 28 dias para as molas fechadas de NiTi foi de 22,6% para American Orthodontics®, 29,8% para Abzil®, 30,6% para Morelli® e 45,8% para TP Orthodontics®. Ao final do experimento, observaram-se diferenças significantes entre as cadeias elastoméricas e as molas fechadas de NiTi. Os resultados permitem recomendar as molas fechadas de NiTi estudadas como dispositivos mais adequados para movimentação dentária do que as cadeias elastoméricas.
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- 2007
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179. Entre madres-adolescentes y adolescentes-madres: un análisis de su trayectoria de vida y los factores que influyen en su configuración
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Irene Del Mastro Naccarato
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adolescencia ,maternidad ,trayectorias ,Social Sciences - Abstract
Analizar las consecuencias de la maternidad adolescente en los ámbitos educativo, laboral y familiar, así como los factores que influyen en la reconfiguración de la trayectoria de vida de la madre adoles- cente tras el embarazo, son los principales objetivos de esta investigación realizada entre los años 2012 y 2013. A partir de trece entrevistas en profundidad a madres adolescentes con hijos entre 2 y 5 años de edad y provenientes de distintos estatus socioeconómicos de Lima, encontramos dos trayectorias tipo: la trayectoria madre adolescente y adolescente-madre. Los hallazgos de este estudio sugieren la importancia del estatus socioeconómico, los roles de género, las concepciones en torno a la adolescencia y al ejercicio de la maternidad, así como las vivencias, características y aspiraciones propias de cada mujer como factores que intervienen en la configuración de la trayectoria de vida de las madres adolescentes.
- Published
- 2015
180. Fibrinogen Depletion Coagulopathy Predicts Major Bleeding After Thrombolysis for Ischemic Stroke: A Multicenter Study.
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Romoli, Michele, Vandelli, Laura, Bigliardi, Guido, Naccarato, Marcello, Moller, Jessica, Balestrino, Maurizio, Giammello, Fabrizio, Gentile, Mauro, Dell'Acqua, Maria Luisa, Manganotti, Paolo, Forlivesi, Stefano, Melis, Maurizio, Picchetto, Livio, Rosafio, Francesca, Furlanis, Giovanni, Testoni, Stefania, Piras, Valeria, Malfatto, Laura, Musolino, Rosa Fortunata, and Scali, Ilario
- Published
- 2022
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181. Summer Engagement for At-Risk Youth: Preliminary Outcomes from the New York State Workforce Development Study
- Author
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Naccarato, Toni, Brophy, Megan, and LaClair, Kirsten
- Published
- 2013
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182. Identification and assay of underivatized urinary acylcarnitines by paper spray tandem mass spectrometry
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Naccarato, Attilio, Moretti, Sacha, Sindona, Giovanni, and Tagarelli, Antonio
- Published
- 2013
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183. Troponin levels in transient ischemic attack and ischemic stroke: does "transient" in your brain mean "better" for your heart?
- Author
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Prandin, G., Caruso, P., Furlanis, G., Rossi, L., Cegalin, M., Scali, I., Mancinelli, L., Palacino, F., Vincis, E., Naccarato, M., and Manganotti, P.
- Abstract
Transient ischemic attack (TIA) is defined as a transient episode of neurological dysfunction caused by focal brain, spinal cord, or retinal ischemia, with clinical symptoms typically lasting less than one hour, and without evidence of acute infarction. In this type of ischemic event, there are no data about a possible cardiac injury tested with troponin. After a stroke, it is well established the cardiac involvement due to a neuro-inflammatory response (recently defined as Stroke Heart Syndrome). The aim of this study is to compare the troponin elevation after a stroke with the troponin elevation after a TIA. This is a retrospective, single center study on 565 patients (73 TIAs, 492 stroke). We collected demographic characteristics, cardiovascular risk factors, cardiac data such as troponin, NT-proBNP, left atrial dilatation, etiology of the ischemic event (TOAST classification). We compare IS and TIA for each TOAST subtype. In all groups no substantial differences were found in demographic and past medical history (p > 0.05). However, the maximum troponin level reached were significantly lower in TIAs than IS (p < 0.05), except in lacunar etiology were troponin elevation was low also in IS group. We found a trend in favor to IS in the rise and fall troponin elevation over 30% in all the TOAST subgroups, but only in the cryptogenic etiology the difference was significant. About the others cardiac markers of injury, a significant higher rate of elevated NT-proBNP was found in the IS cohort. Troponin level after TIAs is significantly lower than after IS. Troponin elevation after an ischemic event may be more relevant in patients with higher NT-proBNP levels and older age. More studies are needed to better understand the pathophysiology of this phenomenon after an ischemic event. [ABSTRACT FROM AUTHOR]
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- 2024
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184. HIPAA Compliant Text Messenger App For Reduction Of Phone Call Interruptions On The Cardiac Ct Service.
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Naccarato, L., Randhawa, M., Badreldin, B., Suero Abreu, G., Ghoshhajra, B., and Hedgire, S.
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- 2024
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185. Characteristics of Respondents to Web-Based or Traditional Interviews in Mixed-Mode Surveys. Evidence from the Italian Permanent Population Census
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Grimaccia, Elena, Naccarato, Alessia, Gallo, Gerardo, Cecconi, Novella, and Fratoni, Alessandro
- Abstract
In order to provide useful tools for researchers in the design of actions to promote participation in web surveys, it is key to study the characteristics that define the profile of a “web respondent”, so that specific interventions can be planned. In this contribution, which draws on data collected during the 2019 housing population census in Italy, we define the set of familial and geographical characteristics that correspond to a greater probability that the interviewed household will choose to respond online, by estimating a multilevel model. The profile of a “computer-assisted web interview household” (CAWI-H) is then defined, on the basis of the structural characteristics of this population. Moreover, the geographical distribution of households is studied according to their distance from the CAWI-H profile. The results show that households that are more distant from the CAWI-H profile have characteristics that correspond to segments of the population generally affected by economic and social fragility; they are mainly elderly, foreigners, residents in small towns, and people with a low level of education. It is to these households in particular that survey designers can address specific actions that can enhance their willingness to participate in web surveys.
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- 2023
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186. Thrombolysis after dabigatran reversal: A nation-wide Italian multicentre study, systematic review and meta-analysis
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Romoli, Michele, Matteo, Eleonora, Migliaccio, Ludovica, Gentile, Mauro, Mosconi, Maria Giulia, Scura, Giuseppe Maria, Naccarato, Marcello, Colangeli, Enrico, Candelaresi, Paolo, Andreone, Vincenzo, Giammello, Fabrizio, Fortunata Musolino, Rosa, Dell’Aera, Cristina, Sepe, Federica Nicoletta, Pronello, Edoardo, Barbarini, Leonardo, Caggiula, Marcella, Rizzo, Federica, Petruzzellis, Marco, Giorli, Elisa, Zedde, Maria Luisa, Anticoli, Sabrina, Mangiardi, Marilena, Muto, Mario, Diana, Francesco, De Angelis, Maria Vittoria, Digiovanni, Anna, Concari, Letizia, La Gioia, Sara, Sessa, Maria, Biguzzi, Sara, Cordici, Francesco, Longoni, Marco, Ruggiero, Maria, Cenciarelli, Silvia, Eusebi, Paolo, Sacco, Simona, Caso, Valeria, Paciaroni, Maurizio, Ricci, Stefano, Zini, Andrea, Toni, Danilo, and Giannandrea, David
- Abstract
Introduction: Recent anticoagulant intake represents a contraindication for thrombolysis in acute ischemic stroke. Idarucizumab reverses the anticoagulant effect of dabigatran, potentially allowing for thrombolysis. This nation-wide observational cohort study, systematic review, and meta-analysis evaluated the efficacy and safety of thrombolysis preceded by dabigatran-reversal in people with acute ischemic stroke.Patients and methods: We recruited people undergoing thrombolysis following dabigatran-reversal at 17 stroke centers in Italy (reversal-group), people on dabigatran treated with thrombolysis without reversal (no-reversal group), and age, sex, hypertension, stroke severity, and reperfusion treatment-matched controls in 1:7 ratio (control-group). We compared groups for symptomatic intracranial hemorrhage (sICH, main outcome), any brain hemorrhage, good functional outcome (mRS 0–2 at 3 months), and death. The systematic review followed a predefined protocol (CRD42017060274), and odds ratio (OR) meta-analysis was implemented to compare groups.Results: Thirty-nine patients in dabigatran-reversal group and 300 matched controls were included. Reversal was associated with a non-significant increase in sICH (10.3% vs 6%, aOR = 1.32, 95% CI = 0.39–4.52), death (17.9% vs 10%, aOR = 0.77, 95% CI = 0.12–4.93) and good functional outcome (64.1% vs 52.8%, aOR = 1.41, 95% CI = 0.63–3.19). No hemorrhagic events or deaths were registered in no-reversal group (n = 12). Pooling data from 3 studies after systematic review (n = 1879), reversal carried a non-significant trend for sICH (OR = 1.53, 95% CI = 0.67–3.50), death (OR = 1.53, 95% CI = 0.73–3.24) and good functional outcome (OR = 2.46, 95% CI = 0.85–7.16).Discussion and conclusion: People treated with reperfusion strategies after dabigatran reversal with idarucizumab seem to have a marginal increase in the risk of sICH but comparable functional recovery to matched patients with stroke. Further studies are needed to define treatment cost-effectiveness and potential thresholds in plasma dabigatran concentration for reversal.
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- 2023
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187. Cost analysis of archives in the pathology laboratories: from safety to management
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Eccher, Albino, Dei Tos, Angelo Paolo, Scarpa, Aldo, L'Imperio, Vincenzo, Munari, Enrico, Troncone, Giancarlo, Naccarato, Antonio Giuseppe, Seminati, Davide, and Pagni, Fabio
- Abstract
ContextDespite the reluctance to invest and the challenging estimation of necessary supporting costs, optimising the archives seems to be one of the hottest topics in the future management of the pathology laboratories. Historically, archives were only partially designed to securely store and organise tissue specimens, and tracking systems were often flawed, posing significant risks to patients’ health and legal ramifications for pathologists.ObjectiveThe current review explores the available data from the literature on archives’ management in pathology, including comprehensive business plans, structure setup, outfit, inventories, ongoing conservation and functional charges.Data sourcesElectronic searches in PubMed-MEDLINE and Embase were made to extract pertinent articles from the literature. Works about the archiving process and storage were included and analysed to extract information. Prepublication servers were ignored. Italian Institutional Regional databases for public competitive bidding processes were queried too.ConclusionsA new emergent feeling in the pathology laboratory is growing for archives management; the digital pathology era is a great opportunity to apply innovation to tracking systems and samples preservation. The main aim is a critical evaluation of the return of investment in developing automatic and tracked archiving processes for improving not only quality, efficacy and efficiency of the labs but also patients’ healthcare.
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- 2023
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188. Erratum to: Elaboration of a nomogram to predict nonsentinel node status in breast cancer patients with positive sentinel node, intraoperatively assessed with one step nucleic amplification: Retrospective and validation phase
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Franco Di Filippo, Simona Di Filippo, Anna Maria Ferrari, Raffaele Antonetti, Alessandro Battaglia, Francesca Becherini, Laia Bernet, Renzo Boldorini, Catherine Bouteille, Simonetta Buglioni, Paolo Burelli, Rafael Cano, Vincenzo Canzonieri, Pierluigi Chiodera, Alfredo Cirilli, Luigi Coppola, Stefano Drago, Luca Di Tommaso, Privato Fenaroli, Roberto Franchini, Andrea Gianatti, Diana Giannarelli, Carmela Giardina, Florence Godey, Massimo M. Grassi, Giuseppe B. Grassi, Siobhan Laws, Samuele Massarut, Giuseppe Naccarato, Maria Iole Natalicchio, Sergio Orefice, Fabrizio Palmieri, Tiziana Perin, Manuela Roncella, Massimo G. Roncalli, Antonio Rulli, Angelo Sidoni, Corrado Tinterri, Maria C. Truglia, and Isabella Sperduti
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2017
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189. Element-by-element estimation of a volatility matrix. An Italian portfolio simulation
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Alessia Naccarato and Andrea Pierini
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Finance ,HG1-9999 - Published
- 2014
190. Heart rate affects endothelial function in essential hypertension
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Maio, Raffaele, Miceli, Sofia, Sciacqua, Angela, Leone, Giulia Galiano, Bruni, Rosamaria, Naccarato, Paola, Martino, Francesco, Sesti, Giorgio, and Perticone, Francesco
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- 2013
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191. Functional MRI during the execution of a motor task in patients with multiple sclerosis and fatigue
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Specogna, I., Casagrande, F., Lorusso, A., Catalan, M., Gorian, A., Zugna, L., Longo, R., Zorzon, M., Naccarato, M., Pizzolato, G., Ukmar, M., and Cova, M. A.
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- 2012
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192. Defensive Secretions of the Carabid Beetle Chlaenius cordicollis: Chemical Components and their Geographic Patterns of Variation
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Holliday, A. E., Holliday, N. J., Mattingly, T. M., and Naccarato, K. M.
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- 2012
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193. Sarcosine as a marker in prostate cancer progression: a rapid and simple method for its quantification in human urine by solid-phase microextraction–gas chromatography–triple quadrupole mass spectrometry
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Cavaliere, Brunella, Macchione, Barbara, Monteleone, Marcello, Naccarato, Attilio, Sindona, Giovanni, and Tagarelli, Antonio
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- 2011
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194. Right hemisphere dysfunction and emotional processing in ALS: an fMRI study
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Palmieri, A., Naccarato, M., Abrahams, S., Bonato, M., D’Ascenzo, C., Balestreri, S., Cima, V., Querin, G., Dal Borgo, R., Barachino, L., Volpato, C., Semenza, C., Pegoraro, E., Angelini, C., and Sorarù, G.
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- 2010
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195. Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease: the ARAPACIS study
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Raparelli, Valeria, Pastori, Daniele, Pignataro, Serena Francesca, Vestri, Anna Rita, Pignatelli, Pasquale, Cangemi, Roberto, Proietti, Marco, Davì, Giovanni, Hiatt, William Robert, Lip, Gregory Yoke Hong, Corazza, Gino Roberto, Perticone, Francesco, Violi, Francesco, Basili, Stefania, Alessandri, C., Serviddio, G., Palange, P., Greco, E., Bruno, G., Averna, M., Giammanco, A., Sposito, P., de Cristofaro, R., Carulli, L., de Gennaro, L., Pellegrini, E., Cominacini, L., Mozzini, C., Pasini, A. F., Sprovieri, M., Spagnuolo, V., Cerqua, G., Cerasola, G., Mulé, G., Barbagallo, M., Lo Sciuto, S., Monteverde, A., Saitta, A., Lo Gullo, A., Malatino, L., Cilia, C., Terranova, V., Pisano, M., Pinto, A., Di Raimondo, D., Tuttolomondo, A., Conigliaro, R., Signorelli, S., de Palma, D., Galderisi, M., Cudemo, G., Galletti, F., Fazio, V., de Luca, N., Meccariello, A., Caputo, D., de Donato, M. T., Iannuzi, A., Bresciani, A., Giunta, R., Utili, R., Iorio, V., Adinolfi, L. E., Sellitto, C., Iuliano, N., Bellis, P., Tirelli, P., Sacerdoti, D., Vanni, D., Iuliano, L., Ciacciarelli, M., Pacelli, A., Palazzuoli, A., Cacciafesta, M., Gueli, N., Lo Iacono, C., Brusco, S., Verrusio, W., Nobili, L., Tarquinio, N., Pellegrini, F., Vincentelli, G. M., Ravallese, F., Santini, C., Letizia, C., Petramala, L., Zinnamosca, L., Minisola, S., Cilli, M., Colangelo, L., Falaschi, P., Martocchia, A., Pastore, F., Bertazzoni, G., Attalla El Halabieh, E., Paradiso, M., Lizzi, E. M., Timmi, S., Battisti, P., Cerci, S., Ciavolella, M., Di Veroli, C., Malci, F., de Ciocchis, A., Abate, D., Castellino, P., Zanoli, L., Fidone, F., Mannarino, E., Pasqualini, L., Oliverio, G., Pende, A., Artom, N., Ricchio, R., Fimognari, F. L., Alletto, M., Messina, S., Sesti, G., Arturi, F., Succurro, E., Fiorentino, T. V., Pedace, E., Scarpino, P. E., Carullo, G., Maio, R., Sciacqua, A., Frugiuele, P., Battaglia, G., Atzori, S., Delitala, G., Angelucci, E., Sestili, S., Traisci, G., de Feudis, L., Di Michele, D., Fava, A., Balsano, C., de Ciantis, P., Desideri, G., Camerota, A., Mezzetti, M., Gresele, P., Vedovati, C., Fierro, T., Puccetti, L., Bertolotti, M., Mussi, C., Boddi, M., Savino, A., Contri, S., Degl’Innocenti, G., Saller, A., Fabris, F., Pesavento, R., Filippi, L., Vedovetto, V., Puato, M., Treleani, M., de Luca, E., de Zaiacomo, F., Giantin, V., Semplicini, A., Minuz, P., Romano, S., Fantin, F., Manica, A., Stockner, I., Pattis, P., Gutmann, B., Catena, C., Colussi, G., Sechi, L. A., Annoni, G., Bruni, A. A., Castagna, A., Spinelli, D., Miceli, E., Padula, D., Schinco, G., Spreafico, S., Secchi, B., Vanoli, M., Casella, G., Pulixi, E. A., Sansone, L., Serra, M. G., Longo, S., Antonaci, S., Belfiore, A., Frualdo, M., Palasciano, G., Ricci, L., Ventrella, F., Bianco, C., Santovito, D., Cipollone, F., Nicolai, S., Salvati, F., Rini, G. B., Scozzari, F., Muiesan, M. L., Salvetti, M., Bazza, A., Picardi, A., Vespasiani-Gentilucci, U., de Vincentis, A., Cosio, P., Terzolo, M., Madaffari, B., Parasporo, B., Fenoglio, L., Bracco, C., Melchio, R., Gentili, T., Salvi, A., Nitti, C., Gabrielli, A., Martino, G. P., Capucci, A., Brambatti, M., Sparagna, A., Tirotta, D., Andreozzi, P., Ettorre, E., Viscogliosi, G., Servello, A., Musumeci, M., Delfino, M., Giorgi, A., Glorioso, N., Melis, G., Marras, G., Matta, M., Sacco, A., Stellitano, E., Scordo, A., Russo, F., Caruso, A. A., Porreca, E., Tana, M., Ferri, C., Cheli, P., Portincasa, P., Muscianisi, G., Giordani, S., Stanghellini, V., Sabbà, C., Mancuso, G., Bartone, M., Calipari, D., Arcidiacono, G., Bellanuova, I., Ferraro, M., Marigliano, G., Cozzolino, D., Lampitella, A., Acri, V., Galasso, D., Mazzei, F., Buratti, A., Galasso, S., Porta, M., Brizzi, M. F., Fattorini, A., Sampietro, F., D’Angelo, A., Manfredini, R., Pala, M., Fabbian, F., Moroni, C., Valente, L., Lopreiato, F., Parente, F., Granata, M., Moia, M., Braham, S., Rossi, M., Pesce, M., Gentile, A., Catozzo, V., Baciarello, G., Cosimati, A., Ageno, W., Rancan, E., Guasti, L., Ciccaglioni, A., Negri, S., Polselli, M., Prisco, D., Marcucci, R., Ferro, D., Perri, L., Cangemi, R., Saliola, M., Del Ben, M., Angelico, F., Baratta, F., Migliacci, R., Porciello, G., Corrao, S., Proietti, M., Raparelli, V., Napoleone, L., Talerico, G., Amoroso, D., Romiti, G. F., Ruscio, E., Toriello, F., Sperduti, N., Todisco, T., Di Tanna, G., Sacchetti, M. L., Puddu, P. E., Farcomeni, A., Anzaldi, M., Bazzini, C., Bianchi, P. I., Boari, B., Buonauro, A., Buttà, C., Buzzetti, E., Calabria, S., Capeci, W., Caradio, F., Carleo, P., Carrabba, M. D., Castorani, L., Cecchetto, L., Cicco, S., Cimini, C., Colombo, B. M., de Giorgi, A., de Vuono, S., Del Corso, L., Denegri, A., Di Giosia, P., Durante Mangoni, E., Falsetti, L., Forgione, A., Giorgini, P., Grassi, D., Grembiale, A., Hijazi, D., Iamele, L., Lorusso, G., Marchese, A., Marra, A. M., Masala, M., Miceli, G., Montebianco Abenavoli, L., Murgia, G., Naccarato, P., Pattoneri, P., Perego, F., Pesce, P., Piano, S., Pinna, M., Pinto, D., Pretti, V., Pucci, G., Salinaro, F., Salzano, A., Santilli, F., Scarpini, F., Scicali, R., Sirico, D., Suppressa, P., Talia, M., Tassone, E. J., Torres, D., Vazzana, N., Vecchio, C. R., Vidili, G., Vitale, F., Zaccone, V., ARAPACIS Study Collaborators, Raparelli, V, Pastori, D, Pignataro, S, Vestri, A, Pignatelli, P, Cangemi, R, Proietti, M, Davi, G, Hiatt, W, Lip, G, Corazza, G, Perticone, F, Violi, F, Basili, S, Alessandri, C, Serviddio, G, Palange, P, Greco, E, Bruno, G, Averna, M, Giammanco, A, Sposito, P, Decristofaro, R, Carulli, L, Degennaro, L, Pellegrini, E, Cominacini, L, Mozzini, C, Pasini, A, Sprovieri, M, Spagnuolo, V, Cerqua, G, Cerasola, G, Mule, G, Barbagallo, M, Lo Sciuto, S, Monteverde, A, Saitta, A, Lo Gullo, A, Malatino, L, Cilia, C, Terranova, V, Pisano, M, Pinto, A, Diraimondo, D, Tuttolomondo, A, Conigliaro, R, Signorelli, S, Depalma, D, Galderisi, M, Cudemo, G, Galletti, F, Fazio, V, Deluca, N, Meccariello, A, Caputo, D, Dedonato, M, Iannuzi, A, Bresciani, A, Giunta, R, Utili, R, Iorio, V, Adinolfi, L, Sellitto, C, Iuliano, N, Bellis, P, Tirelli, P, Sacerdoti, D, Vanni, D, Iuliano, L, Ciacciarelli, M, Pacelli, A, Palazzuoli, A, Cacciafesta, M, Gueli, N, Lo Iacono, C, Brusco, S, Verrusio, W, Nobili, L, Tarquinio, N, Pellegrini, F, Vincentelli, G, Ravallese, F, Santini, C, Letizia, C, Petramala, L, Zinnamosca, L, Minisola, S, Cilli, M, Colangelo, L, Falaschi, P, Martocchia, A, Pastore, F, Bertazzoni, G, Attalla El Halabieh, E, Paradiso, M, Lizzi, E, Timmi, S, Battisti, P, Cerci, S, Ciavolella, M, Diveroli, C, Malci, F, Deciocchis, A, Abate, D, Castellino, P, Zanoli, L, Fidone, F, Mannarino, E, Pasqualini, L, Oliverio, G, Pende, A, Artom, N, Ricchio, R, Fimognari, F, Alletto, M, Messina, S, Sesti, G, Arturi, F, Succurro, E, Fiorentino, T, Pedace, E, Scarpino, P, Carullo, G, Maio, R, Sciacqua, A, Frugiuele, P, Battaglia, G, Atzori, S, Delitala, G, Angelucci, E, Sestili, S, Traisci, G, Defeudis, L, Dimichele, D, Fava, A, Balsano, C, Deciantis, P, Desideri, G, Camerota, A, Mezzetti, M, Gresele, P, Vedovati, C, Fierro, T, Puccetti, L, Bertolotti, M, Mussi, C, Boddi, M, Savino, A, Contri, S, Degl'Innocenti, G, Saller, A, Fabris, F, Pesavento, R, Filippi, L, Vedovetto, V, Puato, M, Treleani, M, Deluca, E, Dezaiacomo, F, Giantin, V, Semplicini, A, Minuz, P, Romano, S, Fantin, F, Manica, A, Stockner, I, Pattis, P, Gutmann, B, Catena, C, Colussi, G, Sechi, L, Annoni, G, Bruni, A, Castagna, A, Spinelli, D, Miceli, E, Padula, D, Schinco, G, Spreafico, S, Secchi, B, Vanoli, M, Casella, G, Pulixi, E, Sansone, L, Serra, M, Longo, S, Antonaci, S, Belfiore, A, Frualdo, M, Palasciano, G, Ricci, L, Ventrella, F, Bianco, C, Santovito, D, Cipollone, F, Nicolai, S, Salvati, F, Rini, G, Scozzari, F, Muiesan, M, Salvetti, M, Bazza, A, Picardi, A, Vespasiani-Gentilucci, U, Devincentis, A, Cosio, P, Terzolo, M, Madaffari, B, Parasporo, B, Fenoglio, L, Bracco, C, Melchio, R, Gentili, T, Salvi, A, Nitti, C, Gabrielli, A, Martino, G, Capucci, A, Brambatti, M, Sparagna, A, Tirotta, D, Andreozzi, P, Ettorre, E, Viscogliosi, G, Servello, A, Musumeci, M, Delfino, M, Giorgi, A, Glorioso, N, Melis, G, Marras, G, Matta, M, Sacco, A, Stellitano, E, Scordo, A, Russo, F, Caruso, A, Porreca, E, Tana, M, Ferri, C, Cheli, P, Portincasa, P, Muscianisi, G, Giordani, S, Stanghellini, V, Sabba, C, Mancuso, G, Bartone, M, Calipari, D, Arcidiacono, G, Bellanuova, I, Ferraro, M, Marigliano, G, Cozzolino, D, Lampitella, A, Acri, V, Galasso, D, Mazzei, F, Buratti, A, Galasso, S, Porta, M, Brizzi, M, Fattorini, A, Sampietro, F, D'Angelo, A, Manfredini, R, Pala, M, Fabbian, F, Moroni, C, Valente, L, Lopreiato, F, Parente, F, Granata, M, Moia, M, Braham, S, Rossi, M, Pesce, M, Gentile, A, Catozzo, V, Baciarello, G, Cosimati, A, Ageno, W, Rancan, E, Guasti, L, Ciccaglioni, A, Negri, S, Polselli, M, Prisco, D, Marcucci, R, Ferro, D, Perri, L, Saliola, M, Delben, M, Angelico, F, Baratta, F, Migliacci, R, Porciello, G, Corrao, S, Napoleone, L, Talerico, G, Amoroso, D, Romiti, G, Ruscio, E, Toriello, F, Sperduti, N, Todisco, T, Ditanna, G, Sacchetti, M, Puddu, P, Farcomeni, A, Anzaldi, M, Bazzini, C, Bianchi, P, Boari, B, Buonauro, A, Butta, C, Buzzetti, E, Calabria, S, Capeci, W, Caradio, F, Carleo, P, Carrabba, M, Castorani, L, Cecchetto, L, Cicco, S, Cimini, C, Colombo, B, De Giorgi, A, Devuono, S, Delcorso, L, Denegri, A, Digiosia, P, Durante Mangoni, E, Falsetti, L, Forgione, A, Giorgini, P, Grassi, D, Grembiale, A, Hijazi, D, Iamele, L, Lorusso, G, Marchese, A, Marra, A, Masala, M, Miceli, G, Montebianco Abenavoli, L, Murgia, G, Naccarato, P, Pattoneri, P, Perego, F, Pesce, P, Piano, S, Pinna, M, Pinto, D, Pretti, V, Pucci, G, Salinaro, F, Salzano, A, Santilli, F, Scarpini, F, Scicali, R, Sirico, D, Suppressa, P, Talia, M, Tassone, E, Torres, D, Vazzana, N, Vecchio, C, Vidili, G, Vitale, F, Zaccone, V, Raparelli, V1, Pastori, D1, Pignataro, Sf1, Vestri, Ar2, Pignatelli, P1, Cangemi, R1, Proietti, M3, Davì, G4, Hiatt, Wr5, Lip, Gyh3, Corazza, Gr6, Perticone, F7, Violi, F8, Basili, S1, De Cristofaro, R, De Gennaro, L, Pasini, Af, Mulé, G, Di Raimondo, D, De Palma, D, De Luca, N, De Donato, Mt, Adinolfi, Le, Vincentelli, Gm, Lizzi, Em, Di Veroli, C, De Ciocchis, A, Fimognari, Fl, Fiorentino, Tv, Scarpino, Pe, De Feudis, L, Di Michele, D, De Ciantis, P, De Luca, E, De Zaiacomo, F, Sechi, La, Bruni, Aa, Pulixi, Ea, Serra, Mg, Rini, Gb, Muiesan, Ml, De Vincentis, A, Martino, Gp, Caruso, Aa, Sabbà, C, Brizzi, Mf, Del Ben, M, Romiti, Gf, Di Tanna, G, Sacchetti, Ml, Puddu, Pe, Bianchi, Pi, Buttà, C, Carrabba, Md, Colombo, Bm, De Vuono, S, Del Corso, L, Di Giosia, P, Marra, Am, Tassone, Ej, Vecchio, Cr, Zaccone, V., Pignataro, Sf, Vestri, Ar, Davì, G, Hiatt, Wr, Lip, Gyh, Corazza, Gr, Raparelli, Valeria, Pastori, Daniele, Pignataro, Serena Francesca, Vestri, Anna Rita, Pignatelli, Pasquale, Cangemi, Roberto, Proietti, Marco, Davì, Giovanni, Hiatt, William Robert, Lip, Gregory Yoke Hong, Corazza, Gino Roberto, Perticone, Francesco, Violi, Francesco, Basili, Stefania, Alessandri C., Serviddio G., Palange P., Greco E., Bruno G., Averna M., Giammanco A., Sposito P., De Cristofaro R., Carulli L., De Gennaro L., Pellegrini E. Cominacini L., Mozzini C., Pasini A.F., Sprovieri M., Spagnuolo V., Cerqua G., Cerasola G., Mulé G., Barbagallo M., Lo Sciuto S., Monteverde A., Saitta A., Lo Gullo A., Malatino L., Cilia C., Terranova V., Pisano M., Pinto A., Di Raimondo D., Tuttolomondo A., Conigliaro R., Signorelli S., De Palma D., Galderisi M., Cudemo G., Galletti F., Fazio V., De Luca N., Meccariello A., Caputo D., De Donato M. T., Iannuzi A., Bresciani A., Giunta R., Utili R., Iorio V., Adinolfi L.E., Sellitto C., Iuliano N., Bellis P., Tirelli P., Sacerdoti D., Vanni D., Iuliano L., Ciacciarelli M., Pacelli A., Palazzuoli A., Cacciafesta M., Gueli N., Lo Iacono C., Brusco S., Verrusio W., Nobili L., Tarquinio N., Pellegrini F., Vincentelli G.M., Ravallese F., Santini C., Letizia C., Petramala L., Zinnamosca L., Minisola S., Cilli M., Colangelo L., Falaschi P., Martocchia A., Pastore F., Bertazzoni G., Attalla El Halabieh E., Paradiso M., Lizzi E.M., Timmi S., Battisti P., Cerci S., Ciavolella M., Di Veroli C., Malci F., De Ciocchis A., Abate D., Castellino P., Zanoli L., Fidone F., Mannarino E., Pasqualini L., Oliverio G., Pende A., Artom N., Ricchio R., Fimognari F.L., Alletto M., Messina S., Sesti G., Arturi F., Succurro E, Fiorentino T.V., Pedace E., Scarpino P.E., Carullo G., Maio R., Sciacqua A., Frugiuele P., Spagnuolo V., Battaglia G., Atzori S., Delitala G., Angelucci E., Sestili S., Traisci G., De Feudis L., Di Michele D., Fava A., Balsano C., De Ciantis P., Desideri G., Camerota A., Mezzetti M., Gresele P., Vedovati C., Fierro T., Puccetti L., Bertolotti M., Mussi C., Boddi M., Savino A., Contri S., Degl’Innocenti G., Saller A., Fabris F., Pesavento R., Filippi L., Vedovetto V., Puato M., Fabris F., Treleani M., De Luca E., De Zaiacomo F., Giantin V., Semplicini A., Minuz P., Romano S., Fantin F., Manica A., Stockner I., Pattis P., Gutmann B., Catena C., Colussi G., Sechi L.A., Annoni G., Bruni A.A., Castagna A., Spinelli D., Miceli E., Padula D., Schinco G., Spreafico S., Secchi B., Vanoli M., Casella G., Pulixi E.A., Sansone L., Serra M.G., Longo S., Antonaci S., Belfiore A., Frualdo M., Palasciano G., Ricci L., Ventrella F., Bianco C., Santovito D., Cipollone F., Nicolai S., Salvati F., Rini G. B., Scozzari F., Muiesan M.L., Salvetti M., Bazza A., Picardi A., Vespasiani-Gentilucci U., De Vincentis A., Cosio P., Terzolo M., Madaffari B., Parasporo B., Fenoglio L., Bracco C., Melchio R., Gentili T., Salvi A., Nitti C., Gabrielli A., Martino G.P., Capucci A., Brambatti M., Sparagna A., Tirotta D., Andreozzi P., Ettorre E., Viscogliosi G., Servello A., Musumeci M., Delfino M., Giorgi A., Glorioso N., Melis G., Marras G., Matta M., Sacco A., Stellitano E., Scordo A., Russo F., Caruso A.A., Porreca E., Tana M., Ferri C., Cheli P., Portincasa P., Muscianisi G., Giordani S., Stanghellini V., Sabbà C., Mancuso G., Bartone M., Calipari D., Arcidiacono G., Bellanuova I., Ferraro M., Marigliano G., Cozzolino D., Lampitella A., Acri V., Galasso D., Mazzei F., Buratti A., Galasso S., Porta M., Brizzi M.F., Fattorini A., Sampietro F., D’Angelo A., Manfredini R., Pala M., Fabbian F., Moroni C., Valente L., Lopreiato F., Parente F., Granata M., Moia M., Braham S., Rossi M., Pesce M., Gentile A., Catozzo V., Baciarello G., Cosimati A., Ageno W., Rancan E., Guasti L., Ciccaglioni A., Negri S., Polselli M., Prisco D., Marcucci R., Ferro D., Perri L., Cangemi R., Saliola M., Del Ben M., Angelico F., Baratta F., Migliacci R., Porciello G., Corrao S. Data entry and Safety Monitoring Board: Proietti M., Raparelli V., Napoleone L., Talerico G., Amoroso D., Romiti G.F., Ruscio E., Toriello F., Sperduti N., Todisco T., Di Tanna G., Sacchetti M.L., Puddu P.E., Farcomeni A. Simi Young Internists Group: Anzaldi M., Bazzini C., Bianchi P.I., Boari B., Bracco C., Buonauro A., Buttà C., Buzzetti E., Calabria S., Capeci W., Caradio F., Carleo P., Carrabba M.D., Castorani L., Cecchetto L., Cicco S., Cimini C., Colombo B.M., De Giorgi A., De Vuono S., Del Corso L., Denegri A., Di Giosia P., Durante Mangoni E., Falsetti L., Forgione A., Giorgini P., Grassi D., Grembiale A., Hijazi D., Iamele L., Lorusso G., Marchese A., Marra A.M., Masala M., Miceli G., Montebianco Abenavoli L., Murgia G., Naccarato P., Padula D., Pattoneri P., Perego F., Pesce P., Piano S., Pinna M., Pinto D., Pretti V., Pucci G., Salinaro F., Salzano A., Santilli F., Scarpini F., Scicali R., Sirico D., Suppressa P., Talia M., Tassone E.J., Torres D., Vazzana N., Vecchio C.R., Vidili G., Vitale F., Zaccone V., Raparelli Valeria, Pastori Daniele, Pignataro Serena Francesca, Vestri Anna Rita, Pignatelli Pasquale, Cangemi Roberto, Proietti Marco, Davì Giovanni, Hiatt William Robert, Lip Gregory Yoke Hong, Corazza Gino Roberto, Perticone Francesco, Violi Francesco, Basili Stefania, Alessandri C, Serviddio G, Palange P, Greco E, Bruno G, Averna M, Giammanco A, Sposito P, De Cristofaro R, Carulli L, De Gennaro L, Pellegrini E, Cominacini L, Mozzini C, Pasini AF, Sprovieri M, Spagnuolo V, Cerqua G, Cerasola G, Mulé G, Barbagallo M, Lo Sciuto S, Monteverde A, Saitta A, Lo Gullo A, Malatino L, Cilia C, Terranova V, Pisano M, Pinto A, Di Raimondo D, Tuttolomondo A, Conigliaro R, Signorelli S, De Palma D, Galderisi M, Cudemo G, Galletti F, Fazio V, De Luca N, Meccariello A, Caputo D, De Donato MT, Iannuzi A, Bresciani A, Giunta R, Utili R, Iorio V, Adinolfi LE, Sellitto C, Iuliano N, Bellis P, Tirelli P, Sacerdoti D, Vanni D, Iuliano L, Ciacciarelli M, Pacelli A, Palazzuoli A, Cacciafesta M, Gueli N, Lo Iacono C, Brusco S, Verrusio W, Nobili L, Tarquinio N, Pellegrini F, Vincentelli GM, Ravallese F, Santini C, Letizia C, Petramala L, Zinnamosca L, Minisola S, Cilli M, Colangelo L, Falaschi P, Martocchia A, Pastore F, Bertazzoni G, Attalla El Halabieh E, Paradiso M, Lizzi EM, Timmi S, Battisti P, Cerci S, Ciavolella M, Di Veroli C, Malci F, De Ciocchis A, Abate D, Castellino P, Zanoli L, Fidone F, Mannarino E, Pasqualini L, Oliverio G, Pende A, Artom N, Ricchio R, Fimognari FL, Alletto M, Messina S, Sesti G, Arturi F, Succurro E, Fiorentino TV, Pedace E, Scarpino PE, Carullo G, Maio R, Sciacqua A, Frugiuele P, Battaglia G, Atzori S, Delitala G, Angelucci E, Sestili S, Traisci G, De Feudis L, Di Michele D, Fava A, Balsano C, De Ciantis P, Desideri G, Camerota A, Mezzetti M, Gresele P, Vedovati C, Fierro T, Puccetti L, Bertolotti M, Mussi C, Boddi M, Savino A, Contri S, Degl’Innocenti G, Saller A, Fabris F, Pesavento R, Filippi L, Vedovetto V, Puato M, Treleani M, De Luca E, De Zaiacomo F, Giantin V, Semplicini A, Minuz P, Romano S, Fantin F, Manica A, Stockner I, Pattis P, Gutmann B, Catena C, Colussi G, Sechi LA, Annoni G, Bruni AA, Castagna A, Spinelli D, Miceli E, Padula D, Schinco G, Spreafico S, Secchi B, Vanoli M, Casella G, Pulixi EA, Sansone L, Serra MG, Longo S, Antonaci S, Belfiore A, Frualdo M, Palasciano G, Ricci L, Ventrella F, Bianco C, Santovito D, Cipollone F, Nicolai S, Salvati F, Rini GB, Scozzari F, Muiesan ML, Salvetti M, Bazza A, Picardi A, Vespasiani-Gentilucci U, De Vincentis A, Cosio P, Terzolo M, Madaffari B, Parasporo B, Fenoglio L, Bracco C, Melchio R, Gentili T, Salvi A, Nitti C, Gabrielli A, Martino GP, Capucci A, Brambatti M, Sparagna A, Tirotta D, Andreozzi P, Ettorre E, Viscogliosi G, Servello A, Musumeci M, Delfino M, Giorgi A, Glorioso N, Melis G, Marras G, Matta M, Sacco A, Stellitano E, Scordo A, Russo F, Caruso AA, Porreca E, Tana M, Ferri C, Cheli P, Portincasa P, Muscianisi G, Giordani S, Stanghellini V, Sabbà C, Mancuso G, Bartone M, Calipari D, Arcidiacono G, Bellanuova I, Ferraro M, Marigliano G, Cozzolino D, Lampitella A, Acri V, Galasso D, Mazzei F, Buratti A, Galasso S, Porta M, Brizzi MF, Fattorini A, Sampietro F, D’Angelo A, Manfredini R, Pala M, Fabbian F, Moroni C, Valente L, Lopreiato F, Parente F, Granata M, Moia M, Braham S, Rossi M, Pesce M, Gentile A, Catozzo V, Baciarello G, Cosimati A, Ageno W, Rancan E, Guasti L, Ciccaglioni A, Negri S, Polselli M, Prisco D, Marcucci R, Ferro D, Perri L, Cangemi R, Saliola M, Del Ben M, Angelico F, Baratta F, Migliacci R, Porciello G, Corrao S, Proietti M, Raparelli V, Napoleone L, Talerico G, Amoroso D, Romiti GF, Ruscio E, Toriello F, Sperduti N, Todisco T, Di Tanna G, Sacchetti ML, Puddu PE, Farcomeni A, Anzaldi M, Bazzini C, Bianchi PI, Boari B, Buonauro A, Buttà C, Buzzetti E, Calabria S, Capeci W, Caradio F, Carleo P, Carrabba MD, Castorani L, Cecchetto L, Cicco S, Cimini C, Colombo BM, De Giorgi A, De Vuono S, Del Corso L, Denegri A, Di Giosia P, Durante Mangoni E, Falsetti L, Forgione A, Giorgini P, Grassi D, Grembiale A, Hijazi D, Iamele L, Lorusso G, Marchese A, Marra AM, Masala M, Miceli G, Montebianco Abenavoli L, Murgia G, Naccarato P, Pattoneri P, Perego F, Pesce P, Piano S, Pinna M, Pinto D, Pretti V, Pucci G, Salinaro F, Salzano A, Santilli F, Scarpini F, Scicali R, Sirico D, Suppressa P, Talia M, Tassone EJ, Torres D, Vazzana N, Vecchio CR, Vidili G, Vitale F, and Zaccone V
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Male ,Settore MED/09 - Medicina Interna ,030204 cardiovascular system & hematology ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Risk Factors ,Major cardiovascular event ,Cause of Death ,Risk of mortality ,Prevalence ,Medicine ,030212 general & internal medicine ,Prospective Studies ,Registries ,Prospective cohort study ,Stroke ,Cause of death ,COPD ,Chronic obstructive pulmonary disease ,Incidence ,Hazard ratio ,Atrial fibrillation ,Cardiovascular mortality ,Major cardiovascular events ,Aged ,Atrial Fibrillation ,Cardiovascular Diseases ,Endpoint Determination ,Female ,Follow-Up Studies ,Humans ,Italy ,Predictive Value of Tests ,Internal Medicine ,Emergency Medicine ,Atrial fibrillation, Cardiovascular mortality, Chronic obstructive pulmonary disease, Major cardiovascular events ,Cardiology ,Settore SECS-S/01 - Statistica ,medicine.medical_specialty ,Chronic Obstructive ,Socio-culturale ,Pulmonary Disease ,03 medical and health sciences ,Internal medicine ,cardiovascular diseases ,business.industry ,medicine.disease ,business ,Mace - Abstract
Chronic obstructive pulmonary disease (COPD) increases the risk of mortality in non-valvular atrial fibrillation (NVAF) patients. Data on the relationship of COPD to major cardiovascular events (MACE) in AF have not been defined. The aim of the study is to assess the predictive value of COPD on incident MACE in NVAF patients over a 3-year follow-up. In the Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study (ARAPACIS) cohort, we evaluate the impact of COPD on the following clinical endpoints: MACE (including vascular death, fatal/non-fatal MI and stroke/TIA), cardiovascular (CV) death and all-cause mortality. Among 2027 NVAF patients, patients with COPD (9%) are more commonly male, elderly and at higher thromboembolic risk. During a median 36.0months follow-up, 186 patients experienced MACE: vascular death (n = 72), MI (n = 57), stroke/TIA (n = 57). All major outcomes (including stroke/TIA, MI, vascular death, and all-cause death) are centrally adjudicated. Kaplan–Meier curves show that NVAF patients with COPD are at higher risk for MACE (p < 0.001), CV death (p < 0.001) and all-cause death (p < 0.001). On Cox proportional hazard analysis, COPD is an independent predictor of MACE (Hazard ratio [HR] 1.77, 95% Confidence Intervals [CI] 1.20–2.61; p = 0.004), CV death (HR 2.73, 95% CI 1.76–4.23; p < 0.0001) and all-cause death (HR 2.16, 95% CI 1.48–3.16; p < 0.0001). COPD is an independent predictor of MACE, CV death and all-cause death during a long-term follow-up of NVAF patients.
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- 2018
196. Erythema annulare centrifugum-like eruption associated with pegylated interferon treatment for hepatitis C
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Mark Naccarato, Deborah Yoong, Robert Solomon, and Mario Ostrowski
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interferon, ribavirin, hepatitis C, erythema annulare centrifugum, drug eruption ,Dermatology ,RL1-803 - Abstract
Current standard of treatment for chronic hepatitis C virus infection requires the use of pegylated interferon plus ribavirin. Treatment with these two agents has been associated with numerous side effects, which frequently include dermatologic eruptions. We report a cutaneous eruption associated with interferon having clinical presentation of erythema annulare centrifugum. The eruption occurred within days of the first interferon injection and repeatedly flared following subsequent injections. Our patient was able to continue therapy without interruption, while managing the reaction with topical corticosteroid and oral antihistamine. We conclude that this is a benign cutaneous eruption associated with interferon which can be managed without dis- continuing treatment for hepatitis C.
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- 2013
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197. Transitional Youth Services: Practice Implications from a Systematic Review
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Naccarato, Toni and DeLorenzo, Emily
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- 2008
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198. SnP2S6: A Promising Infrared Nonlinear Optical Crystal with Strong Nonresonant Second Harmonic Generation and Phase-Matchability.
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He, Jingyang, Lee, Seng Huat, Naccarato, Francesco, Brunin, Guillaume, Zu, Rui, Wang, Yuanxi, Miao, Leixin, Wang, Huaiyu, Alem, Nasim, Hautier, Geoffroy, Rignanese, Gian-Marco, Mao, Zhiqiang, and Gopalan, Venkatraman
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- 2022
- Full Text
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199. Contrast-enhanced MR imaging in patients with BI-RADS 3-5 microcalcifications
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Cilotti, A., Iacconi, C., Marini, C., Moretti, M., Mazzotta, D., Traino, C., Naccarato, A. G., Piagneri, V., Giaconi, C., Bevilacqua, G., and Bartolozzi, C.
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- 2007
- Full Text
- View/download PDF
200. LIGHTNING RISK WARNINGS BASED ON ATMOSPHERIC ELECTRIC FIELD MEASUREMENTS IN BRAZIL. DOI: 10.5028/jatm.2011.03032511
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Marco Antonio da Silva Ferro, Jorge Yamasaki, Douglas Roberto M. Pimentel, Kleber Pinheiro Naccarato, and Marcelo Magalhães Fares Saba
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Atmospheric electric field ,Electric field-mill ,Lightning. ,Technology ,Motor vehicles. Aeronautics. Astronautics ,TL1-4050 - Abstract
This paper presents a methodology that employs the electrostatic field variations caused by thundercloud formation or displacement to generate lightning warnings over a region of interest in Southeastern Brazil. These warnings can be used to prevent accidents during hazardous operations, such as the manufacturing, loading, and test of motor-rockets. In these cases, certain equipment may be moved into covered facilities and personnel are required to take shelter. It is also possible to avoid the threat of natural and triggered lightning to launches. The atmospheric electric field database, including the summer seasons of 2007/2008 and 2008/2009 (from November to February), and, for the same period and region, the cloud-to-ground lightning data provided by the Brazilian lightning detection network – BrasilDAT – were used in order to perform a comparative analysis between the lightning warnings and the cloud-to- ground lightning strikes that effectively occurred inside the area of concern. The analysis was done for three areas surrounding the sensor installation defined as circles with 5, 10 and 15 km of radius to determine the most effective detection range. For each area it was done using several critical electric field thresholds: +/- 0.5; +/- 0.8; +/- 0.9; +/- 1.0; +/- 1.2; and +/- 1.5 kV/m. As a result of the reduction of atmospheric electric field data provided by the sensor installed in area of concern and lightning provided by BrasilDAT, it was possible, for each of the areas of alert proposals, to obtain the following parameters: the number of effective alarms; the number of false alarms; and the number of failure to warning. From the analysis of these parameters, it was possible to conclude that, apparently, the most interesting critical electric field threshold to be used is the level of 0.9 kV/m in association with a distance range of 10 km around the point where the sensor is installed.
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- 2012
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