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156. Electrotunable Nanoplasmonics for Amplified Surface Enhanced Raman Spectroscopy

Author

Ma, Ye, Sikdar, Debabrata, Fedosyuk, Aleksandra, Velleman, Leonora, Klemme, Daniel J., Oh, Sang-Hyun, Kucernak, Anthony R. J., Kornyshev, Alexei A., and Edel, Joshua B.

Abstract

Tuning the properties of optical metamaterials in real time is one of the grand challenges of photonics. Being able to do so will enable a class of adaptive photonic materials for use in applications such as surface enhanced Raman spectroscopy and reflectors/absorbers. One strategy to achieving this goal is based on the electrovariable self-assembly and disassembly of two-dimensional nanoparticle arrays at a metal | liquid interface. As expected, the structure results in plasmonic coupling between NPs in the array but perhaps as importantly between the array and the metal surface. In such a system, the density of the nanoparticle array can be reversibly controlled by the variation of electrode potential. Theory suggests that due to a collective plasmon-coupling effect  less than 1 V variation of electrode potential can give rise to a dramatic simultaneous change in optical reflectivity from ∼93% to ∼1% and the amplification of the SERS signal by up to 5 orders of magnitude. This is experimentally demonstrated using a platform based on the voltage-controlled assembly of 40 nm Au-nanoparticle arrays at a TiN/Ag electrode in contact with an aqueous electrolyte. We show that all the physics underpinning the behavior of this platform works precisely as suggested by the proposed theory, setting the electrochemical nanoplasmonics as a promising direction in photonics research.

Published
2020
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164. Recent Advances in Monoclonal Antibody Therapies for Multiple Sclerosis

Author

Wootla, Bharath, primary, Watzlawik, Jens O., additional, Stavropoulos, Nikolaos, additional, Wittenberg, Nathan J., additional, Dasari, Harika, additional, Abdelrahim, Murtada A., additional, Henley, John R., additional, Oh, Sang-Hyun, additional, Warrington, Arthur E., additional, and Rodriguez, Moses, additional

Published
2016
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177. Nanohole-based SPR Instruments with Improved Spectral Resolution Quantify a Broad Range of Antibody-Ligand Binding Kinetics

Author

Im, Hyungsoon, Sutherland, Jamie N., Maynard, Jennifer A., and Oh, Sang-Hyun

Subjects
Kinetics, Biosensing Techniques, Gold, Antigens, Signal-To-Noise Ratio, Surface Plasmon Resonance, Microarray Analysis, Article, Nanostructures, Single-Chain Antibodies
Abstract

We demonstrate an affordable low-noise surface plasmon resonance (SPR) instrument based on extraordinary optical transmission (EOT) in metallic nanohole arrays and quantify a broad range of antibody-ligand binding kinetics with equilibrium dissociation constants ranging from 200 pM to 40 nM. This nanohole-based SPR instrument is straightforward to construct, align, and operate, since it is built around a standard microscope and a portable fiber-optic spectrometer. The measured refractive index resolution of this platform is 3.1 × 10(-6) without on-chip cooling, which is among the lowest reported for SPR sensors based on EOT. This is accomplished via rapid full-spectrum acquisition in 10 ms followed by frame averaging of the EOT spectra, which is made possible by the production of template-stripped gold nanohole arrays with homogeneous optical properties over centimeter-sized areas. Sequential SPR measurements are performed using a 12-channel microfluidic flow cell after optimizing surface modification protocols and antibody injection conditions to minimize mass-transport artifacts. The immobilization of a model ligand, the protective antigen of anthrax on the gold surface, is monitored in real-time with a signal-to-noise ratio of ~860. Subsequently, real-time binding kinetic curves were measured quantitatively between the antigen and a panel of small, 25 kDa single-chain antibodies at concentrations down to 1 nM. These results indicate that nanohole-based SPR instruments have potential for quantitative antibody screening and as a general-purpose platform for integrating SPR sensors with other bioanalytical tools.

Published
2012

182. Bee venom inhibits growth of human cervical tumors in mice

Author

Lee, Hye Lim, primary, Park, Sang Ho, additional, Kim, Tae Myoung, additional, Jung, Yu Yeon, additional, Park, Mi Hee, additional, Oh, Sang Hyun, additional, Yun, Hye Seok, additional, Jun, Hyung Ok, additional, Yoo, Hwan Soo, additional, Han, Sang-Bae, additional, Lee, Ung Soo, additional, Yoon, Joo Hee, additional, Song, Min Jong, additional, and Hong, Jin Tae, additional

Published
2015
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186. Surface plasmon enhanced spectroscopies and time and space resolved methods: general discussion

Author

Baumberg, Jeremy, primary, Nielsen, Michael, additional, Bozhevolnyi, Sergey, additional, Podolskiy, Viktor, additional, Ebbesen, Thomas, additional, Lin, Kaiqiang, additional, Kornyshev, Alexei A., additional, Khurgin, Jacob, additional, Hutchison, James, additional, Matczyszyn, Katarzyna, additional, George, Jino, additional, Cortes, Emiliano, additional, Hugall, James T., additional, Salomon, Adi, additional, Dawson, Paul, additional, Martin, Olivier, additional, Kotni, Santhosh, additional, García de Abajo, F. Javier, additional, Flatté, Michael, additional, Moskovits, Martin, additional, Graham, Duncan, additional, Maier, Stefan, additional, Futamata, Masayuki, additional, Oh, Sang-Hyun, additional, Aizpurua, Javier, additional, Schultz, Zachary, additional, and Sapienza, Riccardo, additional

Published
2015
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189. Applications of plasmonics: general discussion

Author

Bochenkov, Vladimir, primary, Baumberg, Jeremy, additional, Noginov, Mikhail, additional, Benz, Felix, additional, Aldewachi, Hasan, additional, Schmid, Silvan, additional, Podolskiy, Viktor, additional, Aizpurua, Javier, additional, Lin, Kaiqiang, additional, Ebbesen, Thomas, additional, Kornyshev, Alexei A, additional, Hutchison, James, additional, Matczyszyn, Katarzyna, additional, Kumar, Samir, additional, de Nijs, Bart, additional, Rodríguez Fortuño, Francisco, additional, Hugall, James T., additional, de Roque, Pablo, additional, van Hulst, Niek, additional, Kotni, Santhosh, additional, Martin, Olivier, additional, García de Abajo, F. Javier, additional, Flatté, Michael, additional, Mount, Andrew, additional, Moskovits, Martin, additional, Ginzburg, Pavel, additional, Zueco, David, additional, Zayats, Anatoly, additional, Oh, Sang-Hyun, additional, Chen, Yu, additional, Richards, David, additional, Belardini, Alessandro, additional, and Narang, Prineha, additional

Published
2015
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190. A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis

Author

Xu, Xiaohua, primary, Denic, Aleksandar, additional, Jordan, Luke R., additional, Wittenberg, Nathan J., additional, Warrington, Arthur E., additional, Wootla, Bharath, additional, Papke, Louisa M., additional, Zoecklein, Laurie J., additional, Yoo, Daehan, additional, Shaver, Jonah, additional, Oh, Sang-Hyun, additional, Pease, Larry R., additional, and Rodriguez, Moses, additional

Published
2015
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