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1,016 results on '"Park, J.-G."'

154. Tumour volume changes assessed with high-quality KVCT in lung cancer patients undergoing concurrent chemoradiotherapy

Author

Lee, Y H, primary, Kim, Y S, additional, Lee, H C, additional, Lee, S W, additional, Kang, Y N, additional, Kang, J H, additional, Hong, S H, additional, Kim, Y K, additional, Kim, S J, additional, Ahn, M I, additional, Han, D H, additional, Yoo, I R, additional, Park, J G, additional, Sung, S W, additional, and Lee, K Y, additional

Published
2015
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155. Predictive Value of Pharmacokinetics-Adjusted Phenotypic Susceptibility on Response to Ritonavir-Enhanced Protease Inhibitors (PIs) in Human Immunodeficiency Virus-Infected Subjects Failing Prior PI Therapy

Author

Park, J.-G., Pakes, G. E., Eron, J. J., Aweeka, F., Bastow, B., Wu, H., Richman, D. D., Yu, S., and Haubrich, R.

Abstract

The activities of protease inhibitors in vivo may depend on plasma concentrations and viral susceptibility. This nonrandomized, open-label study evaluated the relationship of the inhibitory quotient (IQ [the ratio of drug exposure to viral phenotypic susceptibility]) to the human immunodeficiency virus type 1 (HIV-1) viral load (VL) change for ritonavir-enhanced protease inhibitors (PIs). Subjects on PI-based regimens replaced their PIs with ritonavir-enhanced indinavir (IDV/r) 800/200 mg, fosamprenavir (FPV/r) 700/100 mg, or lopinavir (LPV/r) 400/200 mg twice daily. Pharmacokinetics were assessed at day 14; follow-up lasted 24 weeks. Associations between IQ and VL changes were examined. Fifty-three subjects enrolled, 12 on IDV/r, 33 on FPV/r, and 8 on LPV/r. Median changes (n-fold) (FC) of 50% inhibitory concentrations (IC50s) to the study PI were high. Median 2-week VL changes were −0.7, −0.1, and −1.0 log10 for IDV/r, FPV/r, and LPV/r. With FPV/r, correlations between the IQ and the 2-week change in VL were significant (Spearman's r range, −0.39 to −0.50; P ≤ 0.029). The strongest correlation with response to FPV/r was the IC50 FC (r = 0.57; P = 0.001), which improved when only adherent subjects were included (r = 0.68; P = 0.001). In multivariable analyses of the FPV/r arm that included FC, one measure of the drug concentration, corresponding IQ, baseline VL, and CD4, the FC to FPV was the only significant predictor of VL decline (P < 0.001). In exploratory analyses of all arms, the area under the concentration-time curve IQ was correlated with the week 2 VL change (r = −0.72; P < 0.001). In conclusion, in PI-experienced subjects with highly resistant HIV-1, short-term VL responses to RTV-enhanced FPV/r correlated best with baseline susceptibility. The IQ improved correlation in analyses of all arms where a greater range of virologic responses was observed.

Published
2009
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157. Effect of Low-Dose Ritonavir on the Pharmacokinetics of the CXCR4 Antagonist AMD070 in Healthy Volunteers

Author

Cao, Y. J., Radebaugh, C., Park, J.-G., Wiggins, I., Klingman, K., MacFarland, R., Conley, J., Dunaway, S., Flexner, C. W., Hendrix, C. W., Becker, S., and Kashuba, A. D.

Abstract

AMD070, a CXCR4 antagonist, has demonstrated antiretroviral activity in human immunodeficiency virus-infected patients. Since AMD070 is a substrate of cytochrome P450 3A4 and P-glycoprotein, both of which may be affected by ritonavir, we tested for a ritonavir effect on AMD070 pharmacokinetics. Subjects were given a single 200-mg dose of AMD070 on days 1, 3, and 17. Ritonavir (100 mg every 12 h) was dosed from day 3 to day 18. Blood samples to test for AMD070 concentrations were collected over 48 h after each administration of AMD070. Twenty-three male subjects were recruited. Among them, 21 completed the study, and 2 were discontinued for reasons other than safety. All adverse events were grade 2 or lower. AMD070 alone had the following pharmacokinetic features, given as medians (ranges): 3 h (0.5 to 4 h) for the time to peak blood concentration, 256 ng/ml (41 to 845 ng/ml) for the peak concentration (Cmax), 934 h·ng/ml (313 to 2,127 h·ng/ml) for the area under the concentration-time curve from 0 h to infinity (AUC0-∞), 214 liters/h (94 to 639 liters/h) for apparent body clearance, and 4,201 liters (1,996 to 9,991 liters) for the apparent volume of distribution based on the terminal phase. The initial doses of ritonavir increased the Cmax of AMD070 [geometric mean (90% confidence interval)] by 39% (3 to 89%) and the AUC0-∞ by 60% (29 to 100%). After 14 days of ritonavir dosing, the pharmacokinetic changes in AMD070 persisted. The plasma pharmacokinetics of ritonavir were consistent with previous reports. It is concluded that AMD070 concentrations were increased with concomitant ritonavir dosing for 14 days in healthy volunteers.

Published
2008
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163. Spin-glass state of (Nd,La)0.5Sr1.5MnO4

Author

Park, Junghwan, Lee, Seongsu, Park, J-G, Swainson, Ian, Moritomo, Y., and Ri, H-C

Subjects
equipment and supplies, human activities
Abstract

We studied the low-temperature magnetic properties of single-crystal (Nd1-xLax)0.5Sr1.5MnO4 using ac and dc susceptibility, and magnetization measurements. From this study, we found that Nd-doped samples showed the sign of a different magnetic state below 20 K. A peak in the ac susceptibility signaling the state shows a strong frequency dependence, indicative of the metastable nature of the transition. This metastable nature of the transition is also borne out by the nonzero isothermal remnant magnetization and the difference in the peak temperatures determined from ac and dc susceptibility. A further evidence for this conclusion comes from the absence of magnetic peaks at low temperature in our neutron-diffraction pattern.

Published
2000
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165. Technical report on the Korea-Japan software collaboration

Author

稲村 泰弘, Inamura, Yasuhiro, So, J.-Y., 中島 健次, Nakajima, Kenji, 鈴木 次郎, Suzuki, Jiro, 中谷 健, Nakatani, Takeshi, 梶本 亮一, Kajimoto, Ryoichi, 大友 季哉, Otomo, Toshiya, Moon, M.-K., Lee, C.-H., 安 芳次, Yasu, Yoshiji, 仲吉 一男, Nakayoshi, Kazuo, 千代 浩司, Sendai, Hiroshi, Nam, U.-W., Park, J.-G., 新井 正敏, Arai, Masatoshi, 稲村 泰弘, Inamura, Yasuhiro, So, J.-Y., 中島 健次, Nakajima, Kenji, 鈴木 次郎, Suzuki, Jiro, 中谷 健, Nakatani, Takeshi, 梶本 亮一, Kajimoto, Ryoichi, 大友 季哉, Otomo, Toshiya, Moon, M.-K., Lee, C.-H., 安 芳次, Yasu, Yoshiji, 仲吉 一男, Nakayoshi, Kazuo, 千代 浩司, Sendai, Hiroshi, Nam, U.-W., Park, J.-G., 新井 正敏, and Arai, Masatoshi

Abstract

This report summarizes the two-year (2007-2009) activities of Korea-Japan collaboration of chopper software development. Here we have described the background of the collaboration and the main part of our work. We also discussed briefly a future plan of our collaboration starting in 2010. Some of detailed description on the management of the collaboration as well as related information is given in appendix., 著者所属: 日本原子力研究開発機構(JAEA), JAEA-Technology 2010-047

Published
2011

169. Prognostic implication of mucinous histology in colorectal cancer patients treated with adjuvant FOLFOX chemotherapy

Author

Lee, D-W, primary, Han, S-W, additional, Lee, H J, additional, Rhee, Y-Y, additional, Bae, J M, additional, Cho, N-Y, additional, Lee, K-H, additional, Kim, T-Y, additional, Oh, D-Y, additional, Im, S-A, additional, Bang, Y-J, additional, Jeong, S-Y, additional, Park, K J, additional, Park, J-G, additional, and Kang, G H, additional

Published
2013
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175. Basic Concepts of Polarisation Analysis for Neutron Chopper Spectrometer POLANO at J-PARC

Author

Ohoyama, K., primary, Yokoo, T., additional, Itoh, S., additional, Suzuki, J., additional, Iwasa, K., additional, Sato, T. J., additional, Kira, H., additional, Sakaguchi, Y., additional, Ino, T., additional, Oku, T., additional, Tomiyasu, K., additional, Matsuura, M., additional, Hiraka, H., additional, Fujita, M., additional, Kimura, H., additional, Sato, T., additional, Shimizu, H. M., additional, Arima, T., additional, Takeda, M., additional, Kaneko, K., additional, Hino, M., additional, Muto, S., additional, Nojiri, H., additional, Lee, C. H., additional, Park, J. G., additional, and Choi, S., additional

Published
2013
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196. TbxEr1−xNi5compounds: An ideal model system for competing Ising-XYanisotropy energies

Author

Pirogov, A. N., primary, Park, J.-G., additional, Ermolenko, A. S., additional, Korolev, A. V., additional, Kuchin, A. G., additional, Lee, Seongsu, additional, Choi, Y. N., additional, Park, Junghwan, additional, Ranot, Mahipal, additional, Yi, Junghwan, additional, Gerasimov, E. G., additional, Dorofeev, Yu. A., additional, Vokhmyanin, A. P., additional, Podlesnyak, A. A., additional, and Swainson, I. P., additional

Published
2009
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