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155. Thyroiditis

Author

Pearce, Elizabeth N., Farwell, Alan P., and Braverman, Lewis E.

Subjects
Thyroiditis -- Physiological aspects, Thyroiditis -- Diagnosis, Thyroiditis -- Care and treatment
Abstract

The diagnosis and treatment of thyroiditis are reviewed. Thyroiditis is an inflammation of the thyroid gland. Topics include autoimmune, clinical, and biochemical changes in thyroiditis, terminology, Hashimoto's thyroiditis, painless postpartum thyroiditis, painless sporadic thyroiditis, painful subacute thyroiditis, suppurative thyroiditis, drug-induced thyroiditis, and Reidel's thyroiditis.

Published
2003

157. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study

Author

Pearce Elizabeth N, Meigs James B, Yang Qiong, Hwang Shih-Jen, and Fox Caroline S

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Glomerular filtration rate (GFR) and urinary albumin excretion (UAE) are markers of kidney function that are known to be heritable. Many endocrine conditions have strong familial components. We tested for association between the Affymetrix GeneChip Human Mapping 100K single nucleotide polymorphism (SNP) set and measures of kidney function and endocrine traits. Methods Genotype information on the Affymetrix GeneChip Human Mapping 100K SNP set was available on 1345 participants. Serum creatinine and cystatin-C (cysC; n = 981) were measured at the seventh examination cycle (1998–2001); GFR (n = 1010) was estimated via the Modification of Diet in Renal Disease (MDRD) equation; UAE was measured on spot urine samples during the sixth examination cycle (1995–1998) and was indexed to urinary creatinine (n = 822). Thyroid stimulating hormone (TSH) was measured at the third and fourth examination cycles (1981–1984; 1984–1987) and mean value of the measurements were used (n = 810). Age-sex-adjusted and multivariable-adjusted residuals for these measurements were used in association with genotype data using generalized estimating equations (GEE) and family-based association tests (FBAT) models. We presented the results for association tests using additive allele model. We evaluated associations with 70,987 SNPs on autosomes with minor allele frequencies of at least 0.10, Hardy-Weinberg Equilibrium p-value ≥ 0.001, and call rates of at least 80%. Results The top SNPs associated with these traits using the GEE method were rs2839235 with GFR (p-value 1.6*10-05), rs1158167 with cysC (p-value 8.5*10-09), rs1712790 with UAE (p-value 1.9*10-06), and rs6977660 with TSH (p-value 3.7*10-06), respectively. The top SNPs associated with these traits using the FBAT method were rs6434804 with GFR(p-value 2.4*10-5), rs563754 with cysC (p-value 4.7*10-5), rs1243400 with UAE (p-value 4.8*10-6), and rs4128956 with TSH (p-value 3.6*10-5), respectively. Detailed association test results can be found at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007. Four SNPs in or near the CST3 gene were highly associated with cysC levels (p-value 8.5*10-09 to 0.007). Conclusion Kidney function traits and TSH are associated with SNPs on the Affymetrix GeneChip Human Mapping 100K SNP set. These data will serve as a valuable resource for replication as more SNPs associated with kidney function and endocrine traits are identified.

Published
2007
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163. Contributors

Author

Abu Dayyeh, Barham K., Agostini, Maura, Aiello, Lloyd Paul, Alicic, Radica Z., Anawalt, Bradley D., Ang, Lynn, Angelidi, Angeliki M., Antonio, Leen, Armstrong, David G., Arner, Peter, Assié, Guillaume, Athonvarangkul, Diana, Auchus, Richard J., Avery, Michael B., Avram, Anca M., Baloch, Zubair W., Bancos, Irina, Barb, Diana, Barkhoudarian, Garni, Basaria, Shehzad, Basham, Kaitlin J., Bashari, Waiel, Bastepe, Murat, Batterham, Rachel L., Bauer, Elizabeth M., Bellin, Melena D., Bertherat, Jérôme, Berthon, Annabel, Bhasin, Shalender, Bilezikian, John P., Billington, Emma O., Boelen, Anita, Bouillon, Roger, Brada, Michael, Brent, Gregory A., Broekmans, Frank J., Bronstein, Marcello D., Brown, Edward M., Bulun, Serdar E., Burch, Henry B., Burghard, Anne Claire, Burney, Richard O., Pop-Busui, Rodica, Cagliero, Enrico, Cameron, Sharon, Caoili, Elaine M., Carmeliet, Geert, Cavallerano, Jerry D., Chatterjee, Krishna, Chen, Zi-Jiang, Cheung, N. Wah, Christian, Helen C., Cidlowski, John A., Clavijo, Leonardo C., Clifton-Bligh, Roderick J., Considine, Robert V., Conti, Marco, Copps, Kyle D., Corcuff, Jean- Benoît, D’Alessio, David, Dattani, Mehul T., Davey, Rachel A., Davis, Stephen N., De Felice, Mario, de Kretser, David, DeFranco, Donald B., Demay, Marie B., DeMayo, Francesco J., De Santis, Pascual, Deutsch, Madeline B., Dhatariya, Ketan, Dhillon, Vaninder K., Di Lauro, Roberto, Dillon, Joseph S., Dinneen, Sean F., Doherty, Gerard M., Donahoo, William Troy, Econs, Michael J., Egan, Aoife M., Ehrhardt, Nicole, Ehrmann, David A., Eisenhofer, Graeme, El-Khairi, Ranna, Elisei, Rossella, Else, Tobias, Erickson, Lori A., Erinjeri, Neeta J., Eszlinger, Markus, Eugster, Erica A., Evert, Alison B., Faix, James D., Farooqi, I. Sadaf, Fassnacht, Martin, Fauser, Bart C.J.M., Findlay, David M., Fliers, Eric, Freeman, Mason W., Frydenberg, Mark, Fuller, Peter J., Gagliano-Jucá, Thiago, Gardella, Thomas J., Garrahy, Aoife, Garvey, W. Timothy, German, Michael S., Gershengorn, Marvin C., Gild, Matti, Gilliam, Lisa K., Giudice, Linda C., Glezer, Andrea, Glorieux, Francis H., Goodpaster, Bret H., Grinman, Diego Y., Guasti, Leonardo, Gurnell, Mark, Habra, Mouhammed Amir, Haddad, Nadine G., Halperin, Daniel M., Hammes, Stephen R., Hardman, Sarah, Harmon, Jamie S., Haugen, Bryan R., Hebrok, Matthias, Hedger, Mark P., Heindel, Jerrold J., Hirsch, Irl B., Hobbs, Robin M., Hollenberg, Anthony N., Hruska, Keith A., Husebye, Eystein, Iacovazzo, Donato, Ilie, Mirela Diana, Imel, Erik A., Isaac, Adam L., Jameson, J. Larry, Jasuja, Ravi, Jayasena, Channa N., Johannsson, Gudmundur, Jones, Glenville, Jonklaas, Jacqueline, Jørgensen, Niels, Jüppner, Harald, Juul, Anders, Kahaly, George J., Karavitaki, Niki, Katugampola, Harshini, Keevil, Brian, Kelley, David E., Kellogg, Todd Andrew, Kelly, David F., Klein, Ronald, Kleinau, Gunnar, Koniares, Katherine, Kopp, Peter, Korbonits, Márta, Korevaar, Tim I.M., Koulouri, Olympia, Krausz, Csilla, Kronenberg, Henry M., La Greca, Amanda, Lamos, Elizabeth M., Lebovitz, Harold E., Hong Lee, Alan Chun, Legro, Richard S., Lenders, Jacques W.M., Lerario, Antonio M., Lernmark, Åke, Lightman, Stafford L., Lin, David S., Liu, Eva S., Lo, Janet, Loomba, Lindsey A., Loveland, Kate L., Lue, Tom F., Lundgren, Markus, MacFarlane, James Robert, Magee, Gregory A., Maes, Christa, Maharaj, Avinaash, Main, Katharina M., Makaronidis, Janine M., Malina, Robert, Mannstadt, Michael, Manohar, Paul, Mantzoros, Christos S., Marazuela, Mónica, Matrone, Antonio, Maxwell, Jessica E., McCartney, Christopher R., McGee, Elizabeth A., Melanson, Edward L., Melmed, Shlomo, Mendelson, Carole R., Merke, Deborah P., Mesiano, Sam, Metherell, Louise A., Miller, Barbra S., Mizokami-Stout, Kara, Mohan, Dipika R., Molitch, Mark E., Moran, Carla, Moravek, Molly B., Neumann, Susanne, Neumiller, Joshua J., Newell-Price, John D.C., Newey, Paul J., Norwitz, Errol R., O’Donnell, Liza, O’Rahilly, Stephen, Oakley, Robert H., Oberfield, Sharon E., Orellana, Minerva, Mete, Ozgur, Pacak, Karel, Pace-Asciak, Pia, Page, Stephanie T., Paschke, Ralf, Pasquel, Francisco J., Pearce, Elizabeth N., Peters, Anne L., Pook, David W., Potts, Callum A., Potts, John T., Jr, Purcell, Sarah A., Raff, Hershel, Ragnarsson, Oskar, Rajpert-De Meyts, Ewa, Ramos-Levi, Ana M., Rao, Sarika N., Rastrelli, Giulia, Raverot, Gérald, Ray, David W., Razavi, Christopher R., Reed-Maldonado, Amanda B., Reid, Ian R., Retnakaran, Ravi, Rickels, Michael R., Riddell, Michael Charles, Rinaudo, Paolo, Risbridger, Gail P., Robertson, R. Paul, Robinson, Bruce G., Rogol, Alan D., Romei, Cristina, Rosenfelder, Nicola, Rowen, Tami S., Ruderman, Neil B., Rushing, John, Russell, Jonathon O., Russo, Jose, Rydén, Mikael, Santoro, Nanette, Schlegel, Peter N., Schoenmakers, Erik, Schoenmakers, Nadia, Senanayake, Russell Martin, Shaear, Mohammad, Shalev, Anath, Shields, James, Shimy, Kim, Shindel, Alan W., Shulman, Gerald I., Silva, Paolo S., Simmons, David, Simon, James A., Singer, Frederick R., Sipos, Jennifer A., Skaznik-Wikiel, Malgorzata E., Smallridge, Robert C., Smith, Christopher J., Smith, Roger, Smith, Ulf, Snyder, Peter J., Solda, Francesca, Speiser, Phyllis W., St-Arnaud, René, Stewart, Elizabeth A., Stowasser, Michael, Straseski, Joely, Strauss, Jerome F., III, Styne, Dennis M., Swerdloff, Ronald S., Tabarin, Antoine, Tanavde, Ved, Taïeb, David, Thakker, Rajesh V., Thompson, Christopher J., Timmers, Henri J.L.M., Toppari, Jorma, Torpy, David J., Tsang, Venessa, Tsoukas, Michael A., Tufano, Ralph P., Tuttle, Katherine R., Udelsman, Robert, Umpierrez, Guillermo, Upton, Thomas J., Vaidya, Anand, Val, Pierre, Vasiljevic, Alexandre, Vaughan, Denis A., Vella, Adrian, Verlinden, Lieve, Vietor, Nicole O., Viglianti, Benjamin L., Vilain, Eric, Barisson Villares Fragoso, Maria Candida, Visser, W. Edward, Walford, Geoffrey, Walker, Marcella D., Wang, Christina, Weetman, Anthony P., Wei, Daimin, White, Kenneth E., White, Morris F., White, Perrin C., Whyte, Michael P., Williams, Matthew James, Witchel, Selma Feldman, Wong, Ka Kit, Wu, Frederick C.W., Wysolmerski, John J., Young, Morag J., Zennaro, Maria-Christina, Zimmerman, Michael B., and Zoeller, R. Thomas

Published
2023
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164. A Hidden Solution

Author

Pramyothin, Pornpoj, Leung, Angela M., Pearce, Elizabeth N., Malabanan, Alan O., and Braverman, Lewis E.

Published
2011
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174. Salivary and lacrimal dysfunction after radioactive iodine for differentiated thyroid cancer: American Head and Neck Society Endocrine Surgery Section and Salivary Gland Section joint multidisciplinary clinical consensus statement of otolaryngology, ophthalmology, nuclear medicine and endocrinology

Author

Singer, Michael C., primary, Marchal, Francis, additional, Angelos, Peter, additional, Bernet, Vic, additional, Boucai, Laura, additional, Buchholzer, Samanta, additional, Burkey, Brian, additional, Eisele, David, additional, Erkul, Evren, additional, Faure, Frederic, additional, Freitag, Suzanne K., additional, Gillespie, Marion Boyd, additional, Harrell, Richard Mack, additional, Hartl, Dana, additional, Haymart, Megan, additional, Leffert, Jonathan, additional, Mandel, Susan, additional, Miller, Barbra S., additional, Morris, John, additional, Pearce, Elizabeth N., additional, Rahmati, Rahmatullah, additional, Ryan, William R., additional, Schaitkin, Barry, additional, Schlumberger, Martin, additional, Stack, Brendan C., additional, Van Nostrand, Doug, additional, Wong, Ka Kit, additional, and Randolph, Gregory, additional

Published
2020
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198. Polybrominated diphenyl ether exposure and thyroid function tests in North American adults

Author

Makey, Colleen M., McClean, Michael D., Braverman, Lewis E., Pearce, Elizabeth N., He, Xue-Mei, Sjodin, Andreas, Weinberg, Janice M., and Webster, Thomas F.

Subjects
Thyroid gland -- Physiological aspects -- Research, Environmental issues, Health
Abstract

BACKGROUND: Polybrominated diphenyl ethers (PBDEs) are flame-retardant chemicals that are added to many consumer products. Multiple animal studies have shown PBDEs to be thyroid hormone (TH) disruptors. Epidemiologic evidence of PBDE exposure associated with TH disruption has been inconclusive. OBJECTIVES: We used repeated measures to estimate associations between serum PBDE concentrations and THs in a North American adult cohort. METHODS: From 2010 to 2011, we collected ≤ 3 serum samples at approximately 6-month intervals from 52 healthy adult office workers from Boston, Massachusetts, for analysis of PBDE congeners and THs. RESULTS: The geometric mean sum concentrations of the most prevalent PBDE congeners (BDE-28, BDE-47, BDE-99, BDE-100, and BDE-153) were 22 ng/g lipid in winter 2010, 23 ng/g lipid in summer 2010, and 19 ng/g lipid in winter 2011. BDE-47 was the predominant congener. Based on a multivariable mixed regression model, we estimated that on average, a 1-ng/g serum increase in BDE-47 was associated with a 2.6-µg/dL decrease in total thyroxine ([T.sub.4]) (95% CI: -4.7, -0.35). Total [T.sub.4] was inversely associated with each PBDE congener. Serum concentrations of PBDEs were not strongly associated with total triiodothyronine ([T.sub.3]), free [T.sub.4], or thyroid-stimulating hormone (TSH). CONCLUSION: These results are consistent with those from animal studies showing that exposure to PBDEs is associated with a decrease in serum [T.sub.4]. Because the other TH concentrations did not appear to be associated with BDE exposures, our findings do not indicate effects on the pituitary-thyroid axis. Taken together, our findings suggest that PBDE exposure might decrease the binding of [T.sub.4] to serum [T.sub.4] binding proteins. http://dx.doi.org/10.1289/ehp.1509755, Introduction Polybrominated diphenyl ethers (PBDEs) have been used since the 1970s as additive flame retardants. The technical formulation pentabromodiphenyl ether (pentaBDE), composed of PBDE congeners containing three to six bromines, [...]

Published
2016
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