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156. Preliminary Data on Safety, Cellular Kinetics and Anti-Leukemic Activity of UCART19, an Allogeneic Anti-CD19 CAR T-Cell Product, in a Pool of Adult and Pediatric Patients with High-Risk CD19+ Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia

Author

Benjamin, Reuben, primary, Graham, Charlotte, additional, Yallop, Deborah, additional, Jozwik, Agnieszka, additional, Ciocarlie, Oana, additional, Jain, Nitin, additional, Jabbour, Elias J., additional, Maus, Marcela V., additional, Frigault, Matthiew, additional, Boissel, Nicolas, additional, Larghero, Jerome, additional, Baruchel, Andre, additional, Mohty, Mohamad, additional, De Moerloose, Barbara, additional, Bloor, Adrian, additional, Frey, Noelle V., additional, Zinaï, Amina, additional, Balandraud, Svetlana, additional, Philippe, Anne, additional, Fouliard, Sylvain, additional, Gauthier, Ludiane, additional, Pauly, Jeanne, additional, Konto, Cyril, additional, Bermingham, Candy, additional, Veys, Paul, additional, and Qasim, Waseem, additional

Published
2018
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158. L'ARCHIPEL D'ESTANN OU L'EXPERIENCE DE LA TRAVERSEE : Emergence de lieux « cinétopiques » à la croisée du cinéma et de l'architecture

Author

Philippe, Anne, Architecture, Territoire, Environnement Normandie (ATE Normandie), École nationale supérieure d'architecture de Normandie (ENSA Normandie), Normandie Université (NU)-Normandie Université (NU), and PHILIPPE, Anne

Subjects
[SHS.ARCHI]Humanities and Social Sciences/Architecture, space management, [SHS.ART] Humanities and Social Sciences/Art and art history, [SHS.ARCHI] Humanities and Social Sciences/Architecture, space management, [SHS.ART]Humanities and Social Sciences/Art and art history
Abstract

Our communication concerns the analysis of the space archipelique peculiar to the collective Estann, (www.annephilippe.fr) whose interdisciplinary works are situated between architecture, arts and between cinema. This space archipelique artistic widely echos the archipelique thought deployed by Edouard Glissant, as one invites to approach the cinema and the architecture when they communicate by " their edge ". In doing so, their aims are transformed: it is not any more a question of building worlds, but of committing the spectator-user to build its own relationship to the world from the experience always renewed by the crossing. A spectator, an actor invents of this fact. His) crossings update a new film space, in perpetual future, at the same time as it generates other spaces somewhere else contained in places. Its crossings update a new film space, in perpetual future, at the same time as it generates other spaces, somewhere else contained in places. So, something of the peculiarities of the "environment" appears, at the same time as suggest the " noise of the world ". (Glissant, 1977)., Notre communication porte sur l'analyse de l'espace archipélique propre au collectif de recherche artistique Estann, (www.annephilippe.fr) dont les oeuvres transdisciplinaires se situent à la croisée de l'architecture, de l'art et du cinéma. Cet espace archipélique fait largement écho à la pensée archipélique déployée par Edouard Glissant, comme une invite à aborder le cinéma et l'architecture lorsqu'ils communiquent par « leur bord ». Ce faisant, leurs visées se transforment : il ne s'agit plus de construire des mondes, mais d'engager le spectateur-usager à construire son propre rapport au monde à partir de l'expérience toujours renouvelée de la traversée. S'invente de ce fait un spectateur actif, acteur. Ces traversées mettent à jour un espace cinématographique nouveau, en perpétuel devenir, en même temps qu'elles génèrent des espaces autres, des ailleurs contenus dans les lieux. Ainsi, quelque chose des singularités du « milieu » se fait jour, en même temps que se donne à entendre le « bruit du monde ». (Glissant, 1977). Mots-clés Archipel, architecture, art, cinéma, traversée.

Published
2016

159. Difference between plasma N- and C-terminally directed beta-endorphin immunoreactivity in infantile autism

Author

Leboyer, Marion, Bouvard, Manuel P., Recasens, Christophe, Philippe, Anne, Guilloud-Bataille, Michel, Bondoux, Dominique, Tabuteau, Francois, Dugas, Michel, Panksepp, Jaak, and Launay, Jean-Marie

Subjects
Beta-endorphin -- Research, Autism -- Research, Health, Psychology and mental health
Abstract

Objective: The authors investigated whether there is excessive opioid activity in infantile autism by measuring plasma [Beta]-endorphin in patients with autism compared with patients who had Rett's syndrome and normal comparison subjects. Method: Radioimmunoassays for [Beta]-endorphin using C-terminally and N-terminally directed antisera were applied to plasma samples from 67 children who met both DSM-III-R and ICD-10 diagnostic criteria for infantile autism, 22 girls with Rett's syndrome, and 67 normal children matched in age and sex with the children with autism. Results: Median N-terminally directed [Beta]-endorphin immunoreactivity appeared to be slightly lower in subjects with autism (7 pg/ml) and clearly higher in the girls with Rett's syndrome (40 pg/ml) than in the comparison subjects (9 pg/ml). Median C-terminally directed [Beta]-endorphin immunoreactivity was higher in the girls with Rett's syndrome (35 pg/ml) and much higher in patients with autism (70 pg/ml) than in comparison subjects (8 pg/ml). Conclusions: These findings demonstrate the existence of a wide discrepancy between C- and N-terminally directed [Beta]-endorphin immunoreactivity among children with autism. Despite the fact that the nature of the antigen recognized in the plasma of autistic children by the C-terminally directed anti-[Beta]-endorphin serum remains to be characterized, the difference between C- and N-terminally directed [Beta]-endorphin immunoreactivity might suggest an abnormal processing of the pro-opiomelanocortin gene in infantile autism.

Published
1994

160. Spatio-Temporal dMRI Acquisition Design: Reducing the Number of $q\tau$ Samples Through a Relaxed Probabilistic Model

Author

Filipiak, Patryk, Fick, Rutger, Petiet, Alexandra, Santin, Mathieu, Philippe, Anne-Charlotte, Lehéricy, Stéphane, Deriche, Rachid, Wassermann, Demian, Computational Imaging of the Central Nervous System (ATHENA), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Centre de Neuro-Imagerie de Recherche (CENIR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Filipiak, Patryk, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] (CENIR), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
diffusion mri, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, acquisition design, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [MATH.MATH-OC] Mathematics [math]/Optimization and Control [math.OC], [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], probabilistic modeling
Abstract

International audience; Acquisition time is a major limitation in recovering brain white matter microstructure with diffusion Magnetic Resonance Imaging. Finding a sampling scheme that maximizes signal quality and satisfies given time constraints is NP-hard. We alleviate that by introducing a relaxed probabilistic model of the problem, for which sub-optimal solutions can be found effectively. Our model is defined in the $q\tau$ space, so that it captures both spacial and temporal phenomena. The experiments on synthetic data and in-vivo diffusion images of the C57Bl6 wild-type mice reveal superiority of our technique over random sampling and even distribution in the $q\tau$ space.

Published
2017

161. Multi-Spherical Diffusion MRI: An in-vivo Test- Retest Study of Time-Dependent q-space Indices

Author

Fick, Rutger, Petiet, Alexandra, Santin, Mathieu, Philippe, Anne-Charlotte, Lehéricy, Stéphane, Deriche, Rachid, Wassermann, Demian, Computational Imaging of the Central Nervous System (ATHENA), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Centre de Neuro-Imagerie de Recherche (CENIR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), ANR-13-MONU-0009,MOSIFAH,Modélisation et simulation multimodales et multiéchelles de l'architecture des fibres myocardiques du cœur humain(2013), European Project: 694665,H2020 ERC,ERC-2015-AdG,CoBCoM(2016), Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] (CENIR), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Fick, Rutger, Modèles Numériques - Modélisation et simulation multimodales et multiéchelles de l'architecture des fibres myocardiques du cœur humain - - MOSIFAH2013 - ANR-13-MONU-0009 - MN - VALID, and Computational Brain Connectivity Mapping - CoBCoM - - H2020 ERC2016-09-01 - 2021-08-31 - 694665 - VALID

Subjects
Multi-Spherical MRI, Diffusion time dependence, Diffusion MRI reconstruction, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, Corpus callosum, Laplacian Regularization, Test-Retest, Signal Sparsity
Abstract

International audience; We assess the test-retest reproducibility of time-dependent q-space indices (qτ-indices) in three C57Bl6 wild-type mice. To estimate qτ-indices from the four-dimensional qτ diffusion signal - varying over 3D q-space and diffusion time - we use our recent Multi-Spherical Diffusion MRI (MS-dMRI) method. Using MS-dMRI we could reliably estimate qτ-indices for two out of three subjects, where acquisition artifacts caused the offsets of the last subject.

Published
2017

162. Brain correlates of apathy in Kleine Levin syndrome: a mean apparent propagator study

Author

Philippe, Anne-Charlotte, Lavault, Sophie, Fick, Rutger, Wassermann, Demian, Valabregue, Romain, Deriche, Rachid, Levy, Richard, Arnulf, Isabelle, Lehéricy, Stéphane, Wassermann, Demian, Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] (CENIR), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Computational Imaging of the Central Nervous System (ATHENA), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Neuro-Imagerie de Recherche (CENIR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Service des Pathologies du sommeil [CHU Pitié-Salpêtrière]

Subjects
[SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Abstract

International audience; Synopsis Kleine-Levin syndrome (KLS) is a rare neurological disorder characterized by episodes of severe hypersomnia, apathy, cognitive impairment, derealization and behavioral disturbances. Between episodes, patients have normal sleep, mood and behavior. Apathy is a prominent clinical feature of KLS but its pathophysiology is not known. Here we used mean apparent propagator to investigate white matter changes in KLS and correlated diffusion changes with apathy scores. Results showed that the corpus callosum was involved in KLS during episodes and mean RTAP measures in the corpus callosum correlated with apathy scores. Results were in accordance with known motivation-based circuits involving the orbitomedial frontal cortex. Purpose Kleine-Levin syndrome (KLS) is a rare neurological disorder that mainly affects adolescents. KLS is characterized by relapsing-remitting episodes of severe hypersomnia, apathy, cognitive impairment, derealization and behavioral disturbances. Between episodes, patients have normal sleep, mood and behavior [1]. Each episode is of brief duration varying from a week to 1-2 months. No definite cause has been identified [1]. Anatomical MRI scan is normal, but brain scintigraphy can be abnormal during and between episodes [2]. Apathy is a prominent clinical feature of KLS [3] but its pathophysiology in the disease remains to be established. The mechanisms responsible for apathy may involve several circuits connecting the frontal lobes to the basal ganglia [4]. Here, we performed TBSS analyses on the return-to-the-axis probability (RTAP) measures that may be linked to apparent axonal diameter and inflammation [5] to analyze the integrity of white matter (WM) microstructure of healthy volunteers (HV) compared to symptomatic (KLS-S) and asymptomatic (KLS-AS) patients. Methods We prospectively included 20 KLS-AS (mean age: 22.2 ± 8.9 years, 9 males) and 20 HV age and sex-matched one by one. Twelve of these 20 patients were also scanned during episodes (KLS-S). Apathy was assessed using the Starkstein Apathy score [6]. Diffusion-weighted images were acquired using a Siemens Verio 3T with a 12-channel head coil (GRAPPA=2; TR/TE=7.7s/92ms; voxel size: 2.5mm isotropic; 64, 32 and 8 gradient directions for b-values of 1800, 700, and 300 s/mm² respectively) and 8 images without diffusion weighting were also acquired. We preprocessed the images using FSL (fsl.fmrib.ox.ac.uk/fsl/fslwiki/) and included correction for susceptibility (topup) and for eddy current distortions (eddycor) and creation of a binary mask of the brain (bet). Then, we generated RTAP maps of all subjects [7]. Voxelwise statistical analyses were carried out using TBSS, part of the FSL comparing RTAP maps of HV versus KLS-AS, HV versus KLS-S and KLS-AS versus KLS-S (paired t-test). Finally, in the TBSS-based ROI, we computed correlations between clinical scores (disease duration and apathy scores) and mean RTAP measures in this ROI and performed tractography on one healthy subject to determine its projection fibers. Results were considered significant at p

Published
2017

164. Hierarchical Bayesian modeling for combining dates in archaeological context

Author

Lanos, Philippe, Philippe, Anne, Géosciences Rennes (GR), Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), IRAMAT-Centre de recherche en physique appliquée à l’archéologie (IRAMAT-CRP2A), Institut de Recherches sur les Archéomatériaux (IRAMAT), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Technologie de Belfort-Montbeliard (UTBM), Université de Nantes (UN), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Centre National de la Recherche Scientifique (CNRS), Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS), ANJA (ANJA), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Laboratoire de Mathématiques Jean Leray (LMJL), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS), ANR-11-MONU-0007,CHRONOMODEL,Modélisation chronologique et développement de logiciel pour le traitement des données de datation en archéométrie, archéologie et sciences de la terre(2011), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne (UBM)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne (UBM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), and Dubigeon, Isabelle

Subjects
individual errors, [SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory, Chronomodel software, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, archéologie, [SDU.STU.GP]Sciences of the Universe [physics]/Earth Sciences/Geophysics [physics.geo-ph], statistique, Bayesian statistics, modelisation, Event model, MCMC methods, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], [SDU.STU.GP] Sciences of the Universe [physics]/Earth Sciences/Geophysics [physics.geo-ph], outlier penalization
Abstract

http://www.numdam.org/item/JSFS_2017__158_2_72_0.pdf; International audience; A Bayesian approach is proposed for combining dates from different dating methods used in archeology. This modeling provides an automatic way to penalize outlying data. Examples are provided from different archeological contexts and involving radiocarbon, luminescence and archaeomagnetic results. This new combination procedure is also applied to the wiggle-matching process in dendrochronological dating. Calculations are based on MCMC numerical techniques and can be performed using the cross-platform ChronoModel application which is free, open source software (FOSS).

Published
2017

166. Interactions spatio-temporelles entre oiseaux limicoles et macrofaune benthique : une approche multi-échelles

Author

Philippe, Anne, LIttoral ENvironnement et Sociétés - UMRi 7266 (LIENSs), Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS), Université de La Rochelle, and Pierrick Bocher

Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences, Macrofaune benthique, Shorebirds, Intertidal mudflats, Benthic macrofauna, Oiseaux limicoles, Vasières intertidales, Predator-prey interactions, Relations proie-prédateur
Abstract

Intertidal mudflats are complex ecosystems undergoing constant changes, home to infaunal invertebrates (benthic macrofauna), and migratory sites for particular birds : shorebirds. This research focuses on predator-prey interactions between shorebirds and their macrobenthic prey. The present thesis is composed of 8 chapters which illustrate different spatio-temporal scales : from seasons to the decade, and from the bay to the migratory flyway. These studies are based on regular benthic sampling of intertidal flats along the Bay of Biscay (France), as well as sampling data from the Dutch Wadden Sea and the Mauritanian Banc d’Arguin. Macrobenthic data (quality, sizes, densities, biomass) are linked with shorebird counts and data about their feeding behaviour (diet reconstruction from isotopes, faeces, modeling and video observations). These eight studies shed light on particular relationships between some prey and their predators, and the ecology of these interactions (including environmental variables such as inundation time, grain size, temperature, primary production, or even latitude). Particular attention is given to the variability of prey and predator behaviour in time and space. Inserts are included in between chapters to illustrate for instance different diet reconstruction techniques, anti-predation traits in marine molluscs, or relation between energy available and site selection in shorebirds.; Les vasières intertidales sont des environnements complexes et changeants, qui abritent des invertébrés enfouis dans le sédiment (la macrofaune benthique) et sont visités de manière saisonnière par de grands migrateurs : les oiseaux limicoles. Ce travail de recherche s’intéresse aux relations proie-prédateur entre les oiseaux limicoles et leur ressource alimentaire : la macrofaune benthique. La thèse est articulée en 8 chapitres qui présentent des études à différentes échelles spatio-temporelles : des saisons à la décennie, et de la baie à la route migratoire. Ces études sont basées sur un échantillonnage régulier des vasières intertidales du Golfe de Gascogne (France) ainsi que d’échantillonnages en mer des Wadden (Pays-Bas) et au Banc d’Arguin (Mauritanie). Les données de macrofaune (qualité, taille, densité, biomasse) sont couplées aux données de comptages de leurs prédateurs ainsi qu’à leur comportement alimentaire (reconstruction du régime alimentaire d’après les isotopes, les fécès, la modélisation ou l’observation de vidéos). Ces huit études apportent un éclairage sur l’écologie de leurs interactions (en intégrant des variables environnementales telles que le temps d’inondation, la granulométrie, la température, la production primaire, ou encore la latitude). Une attention particulière est portée à la variabilité des proies et du comportement alimentaire de leurs prédateurs, dans l’espace et le temps. Des encarts viennent illustrer pour l’un les techniques de reconstruction du régime alimentaire, pour l’autre les défenses développées par les mollusques marins, ou encore la relation entre énergie à disposition et sélection du site pour les limicoles.

Published
2016

167. Early Holocene Indian summer monsoon and its impact on vegetation in the Central Himalaya: Insight from δD and δ 13 C values of leaf wax lipid.

Author

Ghosh, Sambit, Sanyal, Prasanta, Roy, Sohom, Bhushan, Ravi, Sati, SP, Philippe, Anne, and Juyal, Navin

Subjects
LAKE sediments, MONSOONS, WOODY plants, WAXES, RAINFALL, LIPIDS, RIPARIAN plants
Abstract

Increase in rainfall during the early Holocene has been reported from different regions of Indian subcontinent, although the magnitude shows spatial variability with lower change in higher rainfall regions and vice versa. While the early-Holocene rainfall records are available from lowland areas of the Indian sub-continent, the record is poorly documented from the high-altitude Central Himalayan region where orography plays an important role in the spatial variability in the rainfall pattern. For the first time, δDC29, δ13CC29 values of alkane and δ13C values of organic matter from a relict lake of Benital area in the Central Himalaya have been used to reconstruct monsoonal rainfall and contemporary vegetation for last 10.5 ka with an emphasis on the early Holocene. The δDC29 values suggest that the early Holocene was characterized by a wet phase at ca. 9 ka with 25% higher rainfall compared to present while the middle-late-Holocene was relatively arid. The estimated increase in monsoonal rainfall for the early Holocene is the highest compared to the previous report from elsewhere. The magnitude of early-Holocene rainfall estimated in this study suggests that in addition to erosion of the bed-rocks at the head-water region, increased stream power reworked the older floodplain and resulted in 2.3 times higher sediment discharged into the Ganges-Brahmaputra (GB) delta compared to the present discharge. The δ13CC29 values of the lake sediments suggest a transition from woody to non-woody plant assemblages occurred at 7 ka. The poor correlation between δDC29 and δ13CC29 values suggests at higher rainfall, the δ13CC29 values of catchment vegetation were less responsive. [ABSTRACT FROM AUTHOR]

Published
2020
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171. Prise en charge des plaies en structure d’urgence

Author

Lefort, Hugues, primary, Zanker, Caroline, additional, Fromantin, Isabelle, additional, Claret, Pierre-Géraud, additional, Douay, Bénédicte, additional, Ganansia, Olivier, additional, Le Conte, Philippe, additional, Martinez, Mikaël, additional, Rothman, Christophe, additional, Revol, Marc, additional, Valdenaire, Guillaume, additional, Cesareo, Éric, additional, Dahan, Benjamin, additional, Desclefs, Jean-Philippe, additional, Duchenne, Jonathan, additional, Gloaguen, Aurélie, additional, Rerbal, Djamila, additional, Vaux, Julien, additional, Hugenschmitt, Delphine, additional, Picot, Olivier, additional, Landie, Aurélien, additional, Potel, Gilles, additional, Philippe, Anne, additional, Teot, Luc, additional, Meaume, Sylvie, additional, Bodin, Frédéric, additional, Perrot, Pierre, additional, Poitrenaud, Delphine, additional, Bru, Jean-Pierre, additional, Tattevin, Pierre, additional, Bonnet, Eric, additional, Salanne, Sophie, additional, de Jorna, Claire, additional, Lagrée, Marion, additional, and Dubos, François, additional

Published
2018
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172. Preliminary Results of UCART19, an Allogeneic Anti-CD19 CAR T-Cell Product, in a First-in-Human Trial (CALM) in Adult Patients with CD19+ Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia

Author

Graham, Charlotte, primary, Yallop, Deborah, additional, Jozwik, Agnieszka, additional, Patten, Piers, additional, Dunlop, Alan, additional, Ellard, Rose, additional, Stewart, Orla, additional, Potter, Victoria, additional, Metaxa, Victoria, additional, Kassam, Shireen, additional, Farzaneh, Farzin, additional, Devereux, Stephen, additional, Pagliuca, Antonio, additional, Zinai, Amina, additional, Binlich, Florence, additional, Dupouy, Sandra, additional, Philippe, Anne, additional, Balandraud, Svetlana, additional, Dubois, Frédéric, additional, Konto, Cyril, additional, Patel, Premal, additional, Mufti, Ghulam, additional, and Benjamin, Reuben, additional

Published
2017
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174. Multi-Spherical MRI: Breaking the Boundaries of Diffusion Time

Author

Fick, Rutger, Petiet, Alexandra, Santin, Mathieu, Philippe, Anne-Charlotte, Lehéricy, Stéphane, Deriche, Rachid, Wassermann, Demian, Computational Imaging of the Central Nervous System (ATHENA), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] (CENIR), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), ANR-13-MONU-0009,MOSIFAH,Modélisation et simulation multimodales et multiéchelles de l'architecture des fibres myocardiques du cœur humain(2013), European Project: 694665,H2020 ERC,ERC-2015-AdG,CoBCoM(2016), Centre de Neuro-Imagerie de Recherche (CENIR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Fick, Rutger, Modèles Numériques - Modélisation et simulation multimodales et multiéchelles de l'architecture des fibres myocardiques du cœur humain - - MOSIFAH2013 - ANR-13-MONU-0009 - MN - VALID, and Computational Brain Connectivity Mapping - CoBCoM - - H2020 ERC2016-09-01 - 2021-08-31 - 694665 - VALID

Subjects
[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging
Abstract

International audience; Effective representation of the diffusion signal’s dependence on diffusion time is a sought-after, yet still unsolved challenge in diffusion MRI (dMRI). We propose a functional basis approach that is specifically designed to represent the dMRI signal in this four-dimensional space – varying over gradient strength, direction and diffusion time – that we call the multi-spherical space. In particular, we provide regularization tools imposing signal sparsity and signal smoothness to drastically reduce the number of measurements we need to probe the properties of this multi-spherical space.

Published
2016

175. Le corps à l’œuvre dans les cinétopies : corps liquide, Corps sans Organes

Author

Philippe, Anne, Laboratoire Architecture, Ville, Urbanisme, Environnement (LAVUE), École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Ministère de la Culture (MC)-Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS), Nicolas Rémy (dir.), Nicolas Tixier (dir.), Centre National de la Recherche Scientifique (CNRS)-Université Paris Nanterre (UPN)-Ministère de la Culture (MC)-Université Paris 8 Vincennes-Saint-Denis (UP8)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV), Université Paris 8 Vincennes-Saint-Denis (UP8)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Nanterre (UPN)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), and Acquier, Françoise

Subjects
[SHS.ARCHI]Humanities and Social Sciences/Architecture, space management, intime, cinétopie, Corps sans Organes, archipel, collectif, [SHS.ARCHI] Humanities and Social Sciences/Architecture, space management, extime
Abstract

Part of topic : Traces, notations and representations of ambiances; International audience; The author proposes to approach the atmosphere through the prism of cinétopies and basing especially on a musical work of Nicolas Frize. If the work of the artist refers mainly to the notion of soundscape, what happens if we grasp it in terms of ambiance? In return, how do the revealed ambiances enlighten on the nature of the operating ambiance in the cinétopies? This intervention is the opportunity to test these very general questions from a specific example and from the dialectic of intensity it implements.

Published
2016

176. A Bayesian model for the OSL dating of poorly bleached sediment samples

Author

Christophe, Claire, Guérin, Guillaume, Medialdea, Alicia, Mercier, Norbert, Philippe, Anne, IRAMAT-Centre de recherche en physique appliquée à l’archéologie (IRAMAT-CRP2A), Institut de Recherches sur les Archéomatériaux (IRAMAT), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Technologie de Belfort-Montbeliard (UTBM), City College [International Faculty of the University of Sheffield], Laboratoire de Mathématiques Jean Leray (LMJL), Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN), Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), and Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

177. Received dose, equivalent dose, measured dose rates, and implications for OSL age estimates: introducing the Mean Dose Model

Author

Guérin, Guillaume, Christophe, Claire, Philippe, Anne, Lahaye, Christelle, Thomsen, Kristina J., Tribolo, Chantal, Urbanová, Petra, Murray, Andrew S., Jain, Mayank, Guibert, Pierre, Mercier, Norbert, Kreutzer, Sebastian, IRAMAT-Centre de recherche en physique appliquée à l’archéologie (IRAMAT-CRP2A), Institut de Recherches sur les Archéomatériaux (IRAMAT), Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Mathématiques Jean Leray (LMJL), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS), Danmarks Tekniske Universitet (DTU), Aarhus University [Aarhus], Technical University of Denmark [Lyngby] (DTU), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Technologie de Belfort-Montbeliard (UTBM), Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), and Université de Nantes (UN)-Université de Nantes (UN)

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

178. Genetic variation in aggregation behavior in Drosophila and interacting phenotypes

Author

Philippe, Anne-Sophie, Jeanson, Raphael, Pasquaretta, Cristian, Rebaudo, Francois, Sueur, Cedric, Mery, Frederic, Évolution, génomes, comportement et écologie (EGCE), Université Paris-Sud - Paris 11 (UP11)-IRD-Centre National de la Recherche Scientifique (CNRS), Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Département Ecologie, Physiologie et Ethologie (DEPE-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDE]Environmental Sciences
Abstract

International audience; Aggregation behaviour is the tendency for animals to group together, which may have important consequences on individual fitness. We used a combination of experimental and simulation approaches to study how genetic variation and social environment interact to influence aggregation dynamics in Drosophila. To do this, we used two different natural lines of Drosophila that arise from a polymorphism in the foraging gene (rovers and sitters). We placed groups of flies in a heated arena. Flies could freely move towards one of two small, cooler refuge areas. In groups of the same strain, sitters had a greater tendency to aggregate. The observed behavioural variation was based on only two parameters: the probability of entering a refuge and the likelihood of choosing a refuge based on the number of individuals present. We then directly addressed how different strains interact by mixing rovers and sitters within a group. Aggregation behaviour of each line was strongly affected by the presence of the other strain, without changing the decision rules used by each. Individuals obeying local rules shaped complex group dynamics via a constant feedback loop between the individual and the group. This study could help to identify the circumstances under which particular group compositions may improve individual fitness through underlying aggregation mechanisms under specific environmental conditions.

Published
2016

179. Additional file 1: of Profiling olfactory stem cells from living patients identifies miRNAs relevant for autism pathophysiology

Author

Nguyen, Lam, Lepleux, Marylin, MÊlanie Makhlouf, Martin, Christelle, Fregeac, Julien, Siquier-Pernet, Karine, Philippe, Anne, FrançOis Feron, Gepner, Bruno, Rougeulle, Claire, Humeau, Yann, and Colleaux, Laurence

Abstract

Profiling olfactory stem cells from living patients identifies miRNAs relevant for Autism pathophysiology. Figure S1. Relative expression of miRNAs in OMSC in validation round. Figure S2. Expression of reference miRNAs in fibroblasts. Figure S3. Expression of miRNA signature in PBMC. Figure S4. Long term potentiation pathway is predicted to be specifically targeted by miR-146a and miR-221. Table S1. Clinical descriptions of ASD patients whose OMSCs were used for miRNA screening. Table S2. Variants identified by whole exome analysis. Table S3. Genetic etiology of patients included in this analysis. Table S4. Primers used in this study. Table S5. Brief clinical descriptions of ASD patients whose primary skin fibroblasts and/or PBMC were used in follow up study. Table S6. Brief clinical descriptions of patients with ID whose primary skin fibroblasts were used in follow up study. Table S7. Selected enriched pathways predicted to be targeted by miR-146a and miR-221. (DOCX 1821 kb)

Published
2016
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180. Quantifying White Matter Microstructure with aUnified Spatio-Temporal Diffusion Weighted MRIContinuous Representation

Author

Wassermann, Demian, Petiet, Alexandra, Santin, Mathieu, Fick, Rutger, Philippe, Anne-Charlotte, Lehericy, Stéphane, Deriche, Rachid, Computational Imaging of the Central Nervous System (ATHENA), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Neuro-Imagerie de Recherche (CENIR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de Neuroradiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] (CENIR), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Wassermann, Demian

Subjects
[SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, Brain tissue microstructure, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, qt-dMRI, Diffusion MRI
Abstract

International audience; A current problem Diffusion MRI (dMRI) based microscopy under the narrow pulse approximation is how to best exploit the 4D (q-space + diffusion time) nature of the signal. Assaf et al. showed that exploring the dMRI attenuation at different diffusion times provides information on the distribution of axonal diameters within a voxel in their seminal work: AxCaliber. However, AxCaliber requires knowing beforehand the predominant orientation of the axons within the analyzed volume to adjust the q-space sampling accordingly. In this work, we show that our novel sparse representation of the 3D+t dMRI signal, enables the recovery of axonal diameter distribution parameters without the need to know the axonal direction at acquisition time.

Published
2016

181. Bayesian statistics in luminescence dating: The ’baSAR’-model and its implementation in the R package ’Luminescence’

Author

Mercier, Norbert, Kreutzer, Sebastian, Christophe, Claire, Guérin, Guillaume, Guibert, Pierre, Lahaye, Christelle, Lanos, Philippe, Philippe, Anne, Tribolo, Chantal, Dubigeon, Isabelle, Using the world in ancient societies : processes and forms of appropriation of space in Long Time - - LaScArBx2010 - ANR-10-LABX-0052 - LABX - VALID, Institut de Recherches sur les Archéomatériaux (IRAMAT), Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Mathématiques Jean Leray (LMJL), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS), IRAMAT-Centre de recherche en physique appliquée à l’archéologie (IRAMAT-CRP2A), Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS), Géosciences Rennes (GR), Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Technologie de Belfort-Montbeliard (UTBM), Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Technologie de Belfort-Montbeliard (UTBM), Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne (UBM)-Centre National de la Recherche Scientifique (CNRS), Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne (UBM)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne (UBM)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), DFG (SCHM 3051/3-1) in the framework of the programme 'Scientific Networks', project title: 'RLum.Network: Ein Wissenschaftsnetzwerk zur Analyse von Lumineszenzdaten mit R', ANR-10-LABX-0052,LaScArBx,Using the world in ancient societies : processes and forms of appropriation of space in Long Time(2010), Université de Nantes - Faculté des Sciences et des Techniques, Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Centre National de la Recherche Scientifique (CNRS)

Subjects
statistic, [SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, archeology, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], archéologie, statistique, [MATH.MATH-ST] Mathematics [math]/Statistics [math.ST]
Abstract

http://ancienttl.org/ATL_34-2_2016/ATL_34-2_Mercier_p14-21.pdf; International audience; A function named analyse baSAR() was writtenusing the statistical programming languageR and its code is now available within the Rpackage ’Luminescence’. The function allowsthe application of the Bayesian hierarchicalmodel ’baSAR’ proposed by Comb`es et al.(2015) and comes with additional features toanalyse luminescence data in a straight forwardway. Example scripts are provided showing thepossible numerical and graphical outputs.

Published
2016

182. ChronoModel version 1.5 User's manual

Author

Vibet, Marie-Anne, Philippe, Anne, Lanos, Philippe, Dufresne, Philippe, Laboratoire de Mathématiques Jean Leray (LMJL), Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN), Géosciences Rennes (GR), Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), IRAMAT-Centre de recherche en physique appliquée à l’archéologie (IRAMAT-CRP2A), Institut de Recherches sur les Archéomatériaux (IRAMAT), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Technologie de Belfort-Montbeliard (UTBM), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Centre National de la Recherche Scientifique (CNRS), Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), and Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne (UBM)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne (UBM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[INFO]Computer Science [cs]
Abstract

http://www.chronomodel.fr.; International audience; ChronoModel is based on the concept of “Event”. An Event is a point in timefor which we can define a hierarchical Bayesian statistical model.An event is determined by its unknown calendar date. In ChronoModel, differenttypes of measurement may be combined in order to estimate the dateof the event of interest. These measurements may be 14C ages in radiocarbon,paleodose measurements in luminescence, inclination, declination or intensityof the geomagnetic field in archeaomagnetism, typo-chronological references orGaussian measurements.

Published
2016

183. EVENT MODEL: A ROBUST BAYESIAN TOOL FOR CHRONOLOGICAL MODELING

Author

Lanos, Philippe, Philippe, Anne, IRAMAT-Centre de recherche en physique appliquée à l’archéologie (IRAMAT-CRP2A), Institut de Recherches sur les Archéomatériaux (IRAMAT), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Technologie de Belfort-Montbeliard (UTBM), Laboratoire de Mathématiques Jean Leray (LMJL), Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN), ANR-11-MONU-0007,CHRONOMODEL,Modélisation chronologique et développement de logiciel pour le traitement des données de datation en archéométrie, archéologie et sciences de la terre(2011), Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS), Université de Nantes - Faculté des Sciences et des Techniques, and Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)

Subjects
individual errors, MCMC methods, Chronomodel software, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], robustness, outlier penalization, Event model, hierarchical Bayesian statistics
Abstract

We propose a new modeling approach for combining dates through the Event model by using hierarchical Bayesian statistics. The Event model aims to estimate the date of a context (unit of stratification) from individual dates assumed to be contemporaneous and which are affected by errors of different types: laboratory and calibration curve errors and also irreducible errors related to contaminations, taphonomic disturbances, etc, hence the possible presence of outliers. The Event model has a hierarchical structure which makes it possible to distinguish between date of an Event and dates of the artifacts involved. Prior information on the individual irreducible errors is introduced using a uniform shrinkage density with minimal assumptions about Bayesian parameters. The model is extended in the case of stratigraphic sequences which involve several Events with temporal order constraints (relative dating). Calculations are based on MCMC numerical techniques and can be performed using the ChronoModel software which is freeware, open source and cross-platform. This modeling provides a very simple way to automatically penalize outlying data without having to remove them from the dataset. This approach is compared to alternative approaches implemented in Oxcal or BCal software: we show that the Event model is more robust but generally yields less precise credibility intervals. Mathematical formulations are explained in detail and comparisons are done thanks to synthetic examples. Three application examples are shown: the radiocarbon dating of the shroud of Turin, the dating of a medieval potter's kiln in Lezoux (Auvergne, France) by using radiocarbon, archaeomagnetism and thermoluminescence, and the OSL dating of the Shi'bat Dihya 1 sequence in Wadi Surdud middle paleolithic complex (western Yemen).

Published
2015

184. Nouvelles dynamiques sociales en Amérique centrale

Author

Chavarochette, Carine and Philippe, Anne

Subjects
Urban Studies, Cultural Studies, lcsh:Latin America. Spanish America, Sociology and Political Science, lcsh:F1201-3799, lcsh:H1-99, lcsh:Social sciences (General), Demography
Abstract

Constitué de sept pays (Belize, Guatemala, Salvador, Honduras, Nicaragua, Costa Rica et Panama), l’isthme centraméricain est composé d’une mosaïque ethnique (populations amérindiennes mayas, kuna, miskito, bribri mais aussi métisses, afrocaribéennes, garifunas, etc.). Entre Amérique du Nord et Amérique latine, ces différents pays ont souvent expérimenté les mêmes événements politiques. Durant la colonisation espagnole, l’Audience du Guatemala a exercé son influence sur les actuels Salvador, H...

Published
2010

190. 2.20 RESTING-STATE CEREBRAL BLOOD FLOW IN THE SUPERIOR TEMPORAL SULCUS CORRELATES WITH SOCIAL PERCEPTION IMPAIRMENTS IN CHILDREN WITH AUTISM SPECTRUM DISORDER

Author

Saitovitch, Ana, primary, Rechtman, Elza, additional, Lemaitre, Hervé, additional, Douard, Elise, additional, Chabane, Nadia, additional, Philippe, Anne, additional, Grevent, David, additional, Calmon, Raphael, additional, Brunelle, Francis, additional, Boddaert, Nathalie, additional, and Zilbovicius, Monica, additional

Published
2016
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191. Etude de la variation génétique et de la plasticité des comportements sociaux chez la drosophile

Author

Philippe, Anne-Sophie, Évolution, génomes, comportement et écologie (EGCE), Université Paris-Sud - Paris 11 (UP11)-IRD-Centre National de la Recherche Scientifique (CNRS), Université Paris Sud - Paris XI, and Frédéric Mery

Subjects
Foraging polymorphism, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Drosophiles, Social behavior variations, Social interactions, Variation des comportements sociaux, personal and social information, Agrégation, Drosophila, Interactions sociales, Aggregation behavior, Informations personnelles et sociales, Polymorphisme foraging, [SDV.EE.IEO]Life Sciences [q-bio]/Ecology, environment/Symbiosis
Abstract

The social behavior variation is a very important issue for understanding evolution of sociality in animal kingdom. By studying genetic and environmental interactions influence on social behavior in Drosophila melanogaster, this thesis fits with this problematic and focus on the parameters which could explain the social behavior variations. In this research work, we studied and highlighted the existence of social behavior in Drosophila like learning and using social information in a spatial learning task, aggregation behavior and numerous social interactions. These behaviors are the first step before more sociality and their study with no-social species is essential to understand the evolution toward more sociality. The use of two lines from genetic polymorphism of the foraging gene (Rover and Sitter phenotypes) reveals differences in behavior between individuals and enable us to study the influence of genetic and environment parameters. Sitter individuals show more social behavior than Rover ones, using more social information and adopting more aggregation behavior. Variation of the genetic composition of the group influence the aggregation level of Rover individuals. They show more gregarious behavior with majority of Sitter individuals. These observations raise the question of the effects of the information source variations on the social behavior and their implication in interactions variations. The last part of this thesis focuses on the interactions between individuals in 12 different populations of Drosophila melanogaster. This approach revealed an important variation in social organization within species and opens new perspectives to study the evolution of sociality.This research bring new elements on factors influencing the change in social behavior and highlight new perspectives for the study of their evolution.; La variation des comportements sociaux est une problématique très importante pour appréhender l’évolution de la socialité dans le règne animal. Par l’étude des interactions entre les paramètres génétiques et environnementaux sur les comportements sociaux de la drosophile (Drosophila melanogaster), cette thèse s’inscrit dans cette problématique et cherche à mettre en évidence les paramètres déterminants pour la expliquer la variation des comportements sociaux des individus. Au cours de ce travail de recherche, on a pu étudier et mettre en évidence l’existence de comportements sociaux chez la drosophile tels que l’apprentissage et l’utilisation des informations sociales dans un contexte de recherche spatiale, le comportement d’agrégation et l’établissement de nombreuses interactions. Ces comportements sont les premiers pas vers plus de socialité et leur étude est indispensable pour comprendre l’évolution vers plus de coopération et de communication entre les individus. L’utilisation de deux lignées issues du polymorphisme génétique du gène foraging (phénotypes Rover et Sitter) a permis de mettre en évidence des différences de comportements entre les individus et d’étudier les interactions entre paramètres génétiques et environnementaux. Les individus de phénotype Sitter témoignent d’un comportement plus social que les individus Rover, utilisant préférentiellement l’information sociale, ils forment aussi des agrégats plus importants semblant attirés par le plus grand nombre. On note aussi que la variation de la composition génétique du groupe entraine une modification du comportement d’agrégation du groupe. Ainsi, les variations interindividuelles influencent le comportement collectif. Le dernier volet de cette thèse s’intéresse aux interactions entre les individus au sein de 12 populations différentes de l’espèce Drosophila melanogaster. Cette approche a permis de révéler une grande variation de l’organisation sociale des individus au sein d’une même espèce et ouvre de nouvelles perspectives pour étudier l’évolution de la socialité.Ce travail de recherche permet d’apporter de nouveaux éléments sur les facteurs influençant la variation des comportements sociaux et de mettre en avant de nouvelles perspectives pour l’étude de leur évolution.

Published
2015

192. Basal ganglia functional parcellation into specific and overlapping territories with resting state F-MRI

Author

Bardinet Eric, Philippe Anne-Charlotte, Vidailhet Marie, Lehericy Stephane, and Berroir Pierre

Subjects
Motor circuit, Pathology, medicine.medical_specialty, Parkinson's disease, Resting state fMRI, Basal ganglia, medicine, medicine.disease, Spatial extent, Neuroscience
Abstract

The basal ganglia (BG) are divided into functional territories being connected to specific cortical areas. Some regions are also connected to more than one cortical area constituting overlapping territories, which may correspond to regions of lower neuronal selectivity. Changes in the spatial extent of overlapping regions could thus indicate reduced selectivity of neuronal representation as reported in BG disorders such as Parkinson's disease (PD). We propose an innovative method to parcellate the BG non-invasively into specific and overlapping functional territories using resting state fMRI data. Parcellation was coherent into groups of subjects. PD was associated with significant differences in the extent of overlap predominating in the motor circuit in line with the expected reduction in neuronal selectivity in the BG of PD patients.

Published
2015

193. Reducing the number of samples in spatiotemporal dMRI acquisition design.

Author

Filipiak, Patryk, Fick, Rutger, Petiet, Alexandra, Santin, Mathieu, Philippe, Anne‐Charlotte, Lehericy, Stephane, Ciuciu, Philippe, Deriche, Rachid, and Wassermann, Demian

Abstract

Purpose: Acquisition time is a major limitation in recovering brain white matter microstructure with diffusion magnetic resonance imaging. The aim of this paper is to bridge the gap between growing demands on spatiotemporal resolution of diffusion signal and the real‐world time limitations. The authors introduce an acquisition scheme that reduces the number of samples under adjustable quality loss. Methods: Finding a sampling scheme that maximizes signal quality and satisfies given time constraints is NP‐hard. Therefore, a heuristic method based on genetic algorithm is proposed in order to find suboptimal solutions in acceptable time. The analyzed diffusion signal representation is defined in the qτ space, so that it captures both spacial and temporal phenomena. Results: The experiments on synthetic data and in vivo diffusion images of the C57Bl6 wild‐type mouse corpus callosum reveal superiority of the proposed approach over random sampling and even distribution in the qτ space. Conclusions: The use of genetic algorithm allows to find acquisition parameters that guarantee high signal reconstruction accuracy under given time constraints. In practice, the proposed approach helps to accelerate the acquisition for the use of qτ‐dMRI signal representation. [ABSTRACT FROM AUTHOR]

Published
2019
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194. Impact d'une sensibilisation des médecins traitants sur la diminution des prescriptions d'antipsychotiques chez les résidents avec démence en Ehpad.

Author

Philippe, Anne-Sophie, Braunstein, David, Clot-Faybesse, Priscilla, Teissier, Sylvie, Roch, Bénédicte, Micallef, Joëlle, and Bonin-Guillaume, Sylvie

Abstract

Copyright of Gériatrie et Psychologie Neuropsychiatrie du Vieillissement is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018
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195. dMRI tractography of WM fibers to recover the anatomical connectivity supporting a MEG epileptic network

Author

Philippe, Anne-Charlotte, Clerc, Maureen, Papadopoulo, Théodore, Deriche, Rachid, Philippe, Anne-Charlotte, Computational Imaging of the Central Nervous System (ATHENA), Inria Sophia Antipolis - Méditerranée (CRISAM), and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)

Subjects
[SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience
Abstract

National audience; Cerebral organization is determined by segregated and integrated regions both functionally and anatomically. These cerebral networks are the foundations of the execution of major part of cognitive processes. Information about the structure of the white matter (WM) and the functionality of networks are both needed to understand these cerebral networks [1,2]. This abstract proposes an efficient method to inform a given functional network on its anatomical support: how many anatomical connections exist between functionally connected regions and what their geometries are. Diffusion MRI being the only non invasive method allowing to have access to the micro-structure of the WM [3], we used diffusion information to underline the degree of connectivity between functionally connected regions while taking advantage of WM fibers reconstruction to determine the way taken by the anatomical network supporting the functional network. Due to the complex dynamical alteration of epilepsy, the study of large-scale functional connectivity is difficult . But diffusion imaging studies have shown alterations of the WM between epileptic zones and connected areas [4,5]. This methodology allows to add qualitative (degree of connectivity) and geometrical (WM fibers reconstruction) information on the anatomical network supporting an epileptic network mostly determined by magneto-encephalography (MEG).

Published
2012

196. Diffusion Magnetic Resonance information as a regularization term for MEG/EEG inverse problem

Author

Belaoucha, Brahim, Philippe, Anne-Charlotte, Clerc, Maureen, Papadopoulo, Théodore, Computational Imaging of the Central Nervous System (ATHENA), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), ANR-13-PRTS-0011,VIBRATIONS,Interprétation des signaux électrophysiologiques en épilepsie basée sur un cerveau virtuel(2013), BELAOUCHA, BRAHIM, and Programme de Recherche Translationnelle en Santé - Interprétation des signaux électrophysiologiques en épilepsie basée sur un cerveau virtuel - - VIBRATIONS2013 - ANR-13-PRTS-0011 - PRTS - VALID

Subjects
[INFO]Computer Science [cs], [INFO] Computer Science [cs]
Abstract

International audience; Several regularization terms are used to constrain the Magnetoencephalography (MEG) and the Electroencephalography (EEG) inverse problem. It has been shown that the brain can be divided into several regions[1] with functional homogeneity inside each one of them. To locate these regions, we use the structural information coming from the diffusion Magnetic Resonance (dMRI) and more specifically, the anatomical connectivity of the distributed sources computed from dMRI. To invistigate the importance of the dMRI in the source reconstruction, we compare the solution based on dMRI-based parcellation to random parcellation.

Published
2014

197. Propagation of epileptic spikes revealed by diffusion-basedconstrained MEG source reconstruction

Author

Philippe, Anne-Charlotte, Papadopoulo, Théodore, Bénar, Christian G., Badier, Jean-Michel, Clerc, Maureen, Deriche, Rachid, Computational Imaging of the Central Nervous System (ATHENA), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epilepsies, Lesions Cerebrales et Systemes Neuraux de la Cognition, Université de la Méditerranée - Aix-Marseille 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Region PACA, BrainConnectivities, ANR-08-BLAN-0250,ViMAGINE,Neuroimagerie Multimodale des Processus Cérébraux Rapides(2008), Deriche, Rachid, and Blanc - Neuroimagerie Multimodale des Processus Cérébraux Rapides - - ViMAGINE2008 - ANR-08-BLAN-0250 - BLANC - VALID

Subjects
[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-DS]Computer Science [cs]/Data Structures and Algorithms [cs.DS], [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [INFO.INFO-DS] Computer Science [cs]/Data Structures and Algorithms [cs.DS]
Abstract

International audience; Goal: Study of the propagation of an epileptic spike.Method: 1- cortex parcellation via structural information coming from diffusion MRI (dMRI)2- MEG inverse problem on a parcellated source space3- study of the propagation of an epileptic spike via the active parcelsResults on real data allowing to study the spatial propagation of an epileptic spike.

Published
2014

198. Statistical estimation of a class of self-regulating processes

Author

Echelard, Antoine, Lévy Véhel, Jacques, Philippe, Anne, Probabilistic modelling of irregularity and application to uncertainties management ( Regularity ), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Mathématiques Appliquées aux Systèmes - EA 4037 (MAS), Ecole Centrale Paris, and Université de Nantes (UN)

Subjects
[MATH.MATH-PR]Mathematics [math]/Probability [math.PR]
Abstract

To appear in Scandinavian Journal of Statistics; Self-regulating processes are stochastic processes whose local regularity, as measured by the pointwise Hölder exponent, is a function of amplitude. They seem to provide relevant miodels for various signals arising e.g. in geophysics and biomedicine. We propose in this work an estimator of the self-regulating function (that is, the function relating amplitude and Hölder regularity) of the self-regulating midpoint displacement process introduced in [4] and study some of its properties. We prove that it is almost surely convergent and obtain a central limit theorem. Numerical simulations show that the estimator behaves well in practice.

Published
2014

199. Construction of an informative hierarchical prior for a small sample with the help of historical data and application to electricity load forecasting

Author

Launay, Tristan, Philippe, Anne, Lamarche, Sophie, Laboratoire de Mathématiques Jean Leray (LMJL), Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN), EDF R&D (EDF R&D), and EDF (EDF)

Subjects
FOS: Computer and information sciences, ComputingMethodologies_PATTERNRECOGNITION, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], mcmc algorithms, electricity load forecasting, FOS: Mathematics, Applications (stat.AP), Mathematics - Statistics Theory, Statistics Theory (math.ST), informative prior, [STAT.TH]Statistics [stat]/Statistics Theory [stat.TH], Statistics - Applications, small dataset
Abstract

We are interested in the estimation and prediction of a parametric model on a short dataset upon which it is expected to overfit and perform badly. To overcome the lack of data (relatively to the dimension of the model) we propose the construction of an informative hierarchical Bayesian prior based upon another longer dataset which is assumed to share some similarities with the original, short dataset. We illustrate the performance of our prior on simulated dataset from three standard models. Then we apply the methodology to a working model for the electricity load forecasting on real datasets, where it leads to a substantial improvement of the quality of the predictions.

Published
2014

200. Using diffusion MRI information in the Maximum Entropy on Mean framework to solve MEG/EEG inverse problem

Author

Belaoucha, Brahim, Lina, Jean-Marc, Clerc, Maureen, Philippe, Anne-Charlotte, Grova, Christophe, Papadopoulo, Théodore, Computational Imaging of the Central Nervous System (ATHENA), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Centre de Recherches Mathématiques [Montréal] (CRM), Université de Montréal (UdeM), Montreal Neurological Institute and Hospital, and McGill University = Université McGill [Montréal, Canada]

Subjects
[INFO]Computer Science [cs]
Abstract

International audience; Magnetoencephalography (MEG) and Electroencephalography (EEG) inverse problem is well-known to require regularization to avoid ill-posedness. Usually, regularization is based on mathematical criteria (minum norm, ...). Physiologically, the brain is organized in functional parcels and imposing a certain homogeneity of the activity within these parcels was proven to be an efficient way to analyze the MEG/EEG data [1][6]. The parcels information can be computed from diffusion Magnetic Resonances Imaging (dMRI) by grouping together source positions shared the same connectivity profile (computed as tractograms from diffusion images). In this work, three parcel-based inverse problem approaches have been tested. The first two approaches are based on minimum norm with added regularization terms to account for the parcel information. They differ by the use of a hard/soft constraint in the way they impose that the activity is constant within each parcel [4]. The third approach is based on the Maximum Entropy on Mean (MEM) framework [2]. The dMRI-base and random cortex parcellation, we test also the use of Multivariate Source Pre-localization (MSP) [5] in the source reconstruction.

Published
2014
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