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151. Impact of early treatment of MS with interferon beta-1b: cognitive outcomes at the 11-year follow-up of BENEFIT (BENEFIT 11)

Author

Foley, F., Penner, I. -K., Edan, Gilles, Freedman, M. S., Montalban, X., Hartung, H. -P., Hemmer, B., Fox, E. J., Barkhof, F., Schippling, S., Koelbach, R., Pleimes, D., Pohl, C., Sandbrink, R., Suarez, G., Wicklein, E. -M., Kappos, L., Jonchère, Laurent, Yeshiva University, Service de Neurologie [Rennes] = Neurology [Rennes], CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Vrije Universiteit Amsterdam [Amsterdam] (VU), Hôpital universitaire de Zurich, University Hospital Basel [Basel], and Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience; no abstract

Published
2015

152. Optical coherence tomography and ophthalmological findings in patients with CIS treated with interferon beta-1b: 11-year follow-up in BENEFIT (BENEFIT 11)

Author

Lukas, S., Hanson, J. V. M., Edan, Gilles, Freedman, M. S., Montalban, X., Hartung, H. -P., Hemmer, B., Fox, E. J., Barkhof, F., Koelbach, R., Pleimes, D., Pohl, C., Sandbrink, R., Suarez, G., Wicklein, E. -M., Kappos, L., Schippling, S., Jonchère, Laurent, Hôpital universitaire de Zurich, Service de Neurologie [Rennes] = Neurology [Rennes], CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Vrije Universiteit Amsterdam [Amsterdam] (VU), University Hospital Basel [Basel], Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience; no abstract

Published
2015

153. 250 mu g or 500 mu g interferon beta-1b versus 20 mg glatiramer acetate in relapsing-remitting multiple sclerosis: a prospective, randomised, multicentre study

Author

O'Connor, P., Filippi, M., Arnason, B., Comi, G., Cook, S., Goodin, D., Hartung, H., Jeffery, D., Kappos, L., Boateng, F., Filippov, V., Groth, M., Knappertz, V., Kraus, C., Sandbrink, R., Pohl, C., BogumilAbramsky O, T., Achiron, A, Agius, M, Aichner, F, Altenkirch, H, Amato, Mp, Anten, B, Arbizu, T, Ash, P, Ballario, C, Bashir, K, Baum, K, Baumhackl, U, Beaver, G, Belova, A, Berger, J, Berger, T, Berlit, P, Beuche, W, Bhan, V, Bigley, K, Bissay, V, Blake, C, Bö, L, Boyko, A, Brochet, B, Brown, M, Callegaro, D, Carra, A, Carroll, W, Cascione, M, Christie, S, Clanet, M, Clavelou, P, Clementino, Vi, Confavreux, C, Cooper, J, Cross, A, Csanyi, A, Czlonkowska, A, D'Hooghe, M, Damier, P, Debouverie, M, Defer, G, Demina, T, Deri, N, Diem, R, Dressel, A, Dubois, B, Dunne, P, Duquette, P, Durelli, L, Edan, G, Elias, S, Elovaara, I, Esfahani, F, Evtushenko, S, Fabijan, Th, Fernández, O, Ferreira, Ml, Fink, A, Flechter, S, Ford, C, Francesconi, C, Freedman, M, Fryze, W, Gabbai, A, Gács, G, Gallo, Paolo, Gazda, S, Gerloff, C, Glyman, S, Goodman, A, Gottesman, M, Grand'Maison, F, Guarnaccia, J, Gutierrez, A, Haas, J, Hansen, Hj, Hardiman, O, Heard, R, Heidenreich, F, Herbert, J, Herminia Scola, R, Hodgkinson, S, Hoffmann, F, Holub, R, Huddlestone, J, Hughes, B, Hughes, M, Hunter, S, Hurwitz, B, Izquierdo, G, Jacobasch, E, Jacques, F, Jakab, G, Jongen, P, Karageorgiou, C, Karni, A, Kasper, L, Kaufman, M, Keidel, M, Khatri, B, Kiefer, R, Kirzinger, S, Kita, M, Komoly, S, Kotov, S, Kozubski, W, Kumlien, E, Kwiecinski, H, Labouge, P, Laganke, C, Lapierre, Y, Lebrun Frenay, C, Leist, T, Leon, Sa, Luetic, G, Lynch, S, Lynch, T, Malkova, N, Maltezou, M, Markowitz, C, Martin, C, Mattle, H, Mattson, D, Metra, M, Meyding Lamadé, U, Milo, R, Milonas, I, Miller, A, Miller, T, Minagar, A, Mitchell, G, Moreau, T, Mosberg, R, Murphy, R, Nehrych, T, Nikl, J, Odinak, M, Oschmann, P, Owen King, J, Pagani, L, Pereira Damasceno, B, Podemski, R, Pöhlau, D, Pozzilli, C, Rammohan, K, Reunanen, M, Rice, G, Richardson, P, Rivera, V, Rizvi, S, Rogozhyn, V, Rolak, L, Rosenkranz, T, Rotta, R, Sanders, E, Sater, R, Satgur Gupta, A, Schwartz, R, Sedal, L, Sega Jazbec, S, Selchen, D, Selmaj, K, Sheremata, W, Shvets, T, Silver, D, Simsarian, J, Skoromets, A, Smiroldo, J, Sokolova, L, Solovyova, Y, Sommer, N, Spirin, N, Stangel, M, Stark, E, Steinbrecher, A, Stemper, B, Stolyarov, I, Strasser Fuchs, S, Sweeney, B, Tettenborn, B, Thrower, B, Tilbery, Cp, Traboulsee, A, Trojano, M, Tubridy, N, Tyor, W, Valikovics, A, Vermersch, P, Vollmer, T, Voloshyna, N, Vrech, C, Wajgt, A, Weller, B, Wendt, J, Yakhno, N, Yeung, M, Zavalishin, I., O'Connor, P, Filippi, Massimo, Arnason, B, Comi, G, Cook, S, Goodin, D, Hartung, Hp, Jeffery, D, Kappos, L, Boateng, F, Filippov, V, Groth, M, Knappertz, V, Kraus, C, Sandbrink, R, Pohl, C, Bogumil, T., and Dubois, Bénédicte

Subjects
Adult, Male, medicine.medical_specialty, interferon beta-1b, Adolescent, Pharmacology, relapsing-remitting multiple sclerosis, law.invention, Young Adult, Multiple Sclerosis, Relapsing-Remitting, Randomized controlled trial, Double-Blind Method, law, Internal medicine, medicine, Humans, Immunologic Factors, Glatiramer acetate, Adverse effect, Expanded Disability Status Scale, Dose-Response Relationship, Drug, business.industry, Multiple sclerosis, Interferon beta-1b, Brain, Glatiramer Acetate, Interferon-beta, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Clinical trial, Tolerability, glatiramer acetate, Female, Neurology (clinical), business, Peptides, medicine.drug
Abstract

BACKGROUND: The aim of the Betaferon Efficacy Yielding Outcomes of a New Dose (BEYOND) trial was to compare the efficacy, safety, and tolerability of 250 microg or 500 microg interferon beta-1b with glatiramer acetate for treating relapsing-remitting multiple sclerosis. METHODS: Between November, 2003, and June, 2005, 2447 patients with relapsing-remitting multiple sclerosis were screened and 2244 patients were enrolled in this prospective, multicentre, randomised trial. Patients were randomly assigned 2:2:1 by block randomisation with regional stratification to receive one of two doses of interferon beta-1b (250 microg or 500 microg) subcutaneously every other day or 20 mg glatiramer acetate subcutaneously every day. The primary outcome was relapse risk, defined as new or recurrent neurological symptoms separated by at least 30 days from the preceding event and that lasted at least 24 h. Secondary outcomes were progression on the expanded disability status scale (EDSS) and change in T1-hypointense lesion volume. Clinical outcomes were assessed quarterly for 2.0-3.5 years; MRI was done at screening and annually thereafter. Analysis was by per protocol. This study is registered, number NCT00099502. FINDINGS: We found no differences in relapse risk, EDSS progression, T1-hypointense lesion volume, or normalised brain volume among treatment groups. Flu-like symptoms were more common in patients treated with interferon beta-1b (p

Published
2009

154. Erste klinische Ergebnisse nach Implantation einer trifokalen torischen Multifokallinse (tMIOL)

Author

Breyer, Detlev, Kaymak, H., Klabe, K., and Pohl, C.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Nachteile der bisherigen tMIOL sind nur 2 nutzbare Entfernungen, photopische Phänomene und die Notwendigkeit einer hellen Lichtquelle zum Lesen. Wir vergleichen unsere ersten klinischen Erfahrungen mit einer neuen trifokalen tMIOL mit einer bifokalen tMIOL. Methodik: Es wurden[for full text, please go to the a.m. URL], 28. Kongress der Deutschsprachigen Gesellschaft für Intraokularlinsen-Implantation, Interventionelle und Refraktive Chirurgie (DGII)

Published
2014

155. Kapazität von rotationsassymmetrischen MIOL - Vergleich von Visusergebnissen mit Defokuskurven zweier refraktiver MIOL

Author

Kaymak, Hakan, Breyer, D., Klabe, K., and Pohl, C.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Aufgrund der unterschiedlichen optischen Architektur aktueller MIOL weichen Parameter wie Kontrastsehen, Intermediärdistanzoptima sowie Photopsien z.T. erheblich voneinander ab. Die vorliegende Untersuchung befasst sich mit einem Vergleich von zwei refraktiven MIOL (Oculentis), die[for full text, please go to the a.m. URL], 28. Kongress der Deutschsprachigen Gesellschaft für Intraokularlinsen-Implantation, Interventionelle und Refraktive Chirurgie (DGII)

Published
2014
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157. Gas bubble formation in fermenting and non-fermenting yeasts

Author

Kgotle, Evodia Yolander, Swart, C. W., Van Wyk, P. W. J., Pohl, C. H., Kgotle, Evodia Yolander, Swart, C. W., Van Wyk, P. W. J., and Pohl, C. H.

Abstract

English: Literature previously suggested that intracellular gas bubble formation cannot occur in microorganisms even under high gas supersaturation. This observation was disproved with the discovery of gas bubbles in the yeasts Saccharomyces cerevisiae (baking industry) and Saccharomyces pastorianus (Brewing industry). As a result the missing link between the excessive production of carbon dioxide (CO2) by alcoholic fermentation inside the yeast cells and the vigorous release of this CO2 into the surrounding environment was uncovered. Further investigations proved that CO2 was indeed the gas contained inside these gas bubbles yet additional analysis of this gas composition was still needed. Here we investigate the occurrence of gas bubbles in yeasts that are fermenting and non-fermenting to identify any occurring differences and conserved status of gas bubbles formation in yeasts. Gas bubbles occurring in Crabtree-positive fermenting yeasts were observed to be more than those formed in the other yeasts (Crabtree-negative and strictly respiring yeasts). Although this was observed only on fermentable media, while on non-fermentable media less or no gas bubbles were formed. Furthermore, the Crabtree-negative fermenting and strictly respiring yeasts revealed similar results on both fermentable and non-fermentable media, with little to no gas bubble formation. Gas composition analysis was also carried out on three Crabtree-positive yeasts and it indicated the occurrence of five elements that were expected to be present in our samples. Moreover detection of sulphur compounds was observed in the same three samples with varying intensities. Nonetheless further research is still needed to confirm the point of production for these compounds, using more specific and sensitive techniques. From these findings it can be concluded that gas bubble formation is conserved in yeasts, with the amount of bubbles formed depending on the mode of CO2 production. In addition, it is possible, Afrikaans: Literatuur tot dusver het voorgestel dat intrasellulêre gasborrels nie in mikroörganismes kan voorkom nie, selfs nie onder toestande van hoë gas- superversadiging nie. Hierdie waarneming is egter verkeerd bewys met die ontdekking van gasborrels in die giste Saccharomyces cerevisiae (bakkersbedryf) en Saccharomyces pastorianus (brouersbedryf). Die ontbrekende skakel tussen die uitermatige vorming van koolstofdioksied (CO2) tydens alkoholiese fermentasie binne die gisselle en die hoë tempo van CO2 vrystelling na die omliggende omgewing is ontdek. Verdere ondersoek het bewys dat CO2 inderdaad die gas is wat die borrels vul, alhoewel die gassamestelling verder ondersoek moes word. Hier vergelyk ons die teenwoordigheid van gasborrels in gis wat fermenteer met die teenwoordigheid van gasborrels in gis wat nie fermenteer nie om die status van borrelvorming in hierdie giste te bepaal. Meer gasborrels het in Crabtree-positiewe fermenterende gis gevorm wanneer hierdie gis met ander gis vergelyk is (Crabtree-negatiewe fermenterende gis en slegs-respirerende gis). Hierdie verskynsel geld egter net wanneer fermenterende gis op fermenteerbare medium gegroei is, groei op nie-fermenteerbare medium het minder of geen borrels tot gevolg gehad. Verder het die groei van Crabtree-negatiewe fermenterende gis en slegs-respirerende gis op fermenteerbare medium soortgelyke resultate as met groei op nie-fermenteerbare medium gelewer, met geen of min borrelvorming. Die samestelling van die gas in borrels van drie Crabtree-positiewe fermenterende giste is bepaal en die teenwoordigheid van vyf elemente is vasgestel, soos wat verwag is. Verder is die teenwoordigheid van swaelverbindings in dieselfde drie monsters waargeneem maar het egter in hoeveelheid gewissel. Verdere ondersoek met meer spesifieke en sensitiewe toerusting is egter nodig om die hoeveelheid wat gevorm word te kan bevestig. Vanuit hierdie waarnemings kan daar afgelei word dat gasborrel-vorming gekonserveerd is in gis

Published
2016

158. The role of cryptococcal 3-hydroxy fatty acids in mediating interspecies interactions

Author

Mochochoko, Bonang Michael, Sebolai, O. M., Pohl, C. H., Mochochoko, Bonang Michael, Sebolai, O. M., and Pohl, C. H.

Abstract

English: Cryptococcus neoformans is today recognised as an important human pathogen that has arisen from a non-pathogenic terrestrial fungus. Its interactions (specifically antagonistic interactions with other microbes (such as amoeba) in its natural habitat, soil, has led to cryptococcal cells evolving elegant offensive and defensive strategies to survive in nature. Importantly, these qualities seem to be maintained and activated whenever cryptococcal cells engage in antagonistic interactions with other cell types i.e. when in competition with Pseudomonas cells, which is the subject of chapter two, as well as when engaging in parasitism with macrophages, which is the subject of chapter three. Towards this end, in this dissertation, special attention was given to the role of the secondary metabolite, cryptococcal 3-hydroxy C9:0, in mediating the fate of C. neoformans when in contact with these other cell types. In chapter two, it was sought to explore the interactive outcome between cryptoccocal cells and Pseudomonas cells. Both cell types can, in their individual capacity, lead to the development of pneumonia. While the host body has optimal conditions (temperature, ambient air, etc.) to promote the growth of these two pathogens, their growth may be limited by the available nutrients within the confined space of the host lung. It is therefore reasonable to conclude that these microbes would engage in competition in order to exert territorial dominance over the other. To demonstrate this point in vitro, Pseudomonas cells were co-cultured with cryptococcal cells over a period of time. It was subsequently determined that cryptococcal cells dominated Pseudomonas cells. This domination manifested in a significant reduction (p = 0.05) in the number of Pseudomonas cells over a 24-h period. In order to determine if the observed domination could be as a result of the cryptococcal 3-hydroxy fatty acid, 3-OH-C9:0, negatively affecting the growth of Pseudomonas cells, Pseudomo, Afrikaans: Cryptococcus neoformans word tans erken as ‘n belnagrike menslike patogeen wat onstaan het vanaf ‘n nie-patogeniese terrestriële fungus. Sy interaksies (veral antagonistiese interaksies) met ander mikrobe (soos amoeba) in sy natuurlike habitat, grond, het daartoe gelei dat Cryptococcus selle elegante aanvals- en verdedigingstrategieë ontwikkel het om in die natuur te oorleef. Dit is van belang dat hierdie eienskaape blyk behou en geaktiveer te word wanneer Cryptococcus selle deelneem aan antagonistiese interaksies met ander tipes selle d.i. wanneer hulle kompeteer met Pseudomonas selle, die onderwerp van hoofstuk twee, asook wanneer hulle deelneem aan parasitisme met makrofage, die onderwerp van hoofstuk drie. Ter nastrewe van hierdie doel, word in hierdie verhandeling veral aandag gegee aan die rol van die sekondêre metaboliet, 3-hidroksie C9:0 (3-OH-C9:0) vanaf Cryptococcus, in bepaling van die lot van C. neoformans wanner dit in kontak is met hierdie ander seltipes. In hoofstuk twee is gepoog om die interaktiewe uitkoms tussen Cryptococcus selle en Pseudomonas selle te ondersoek. Beide seltipes kan individueel lei tot ontstaan van longontsteking. Alhoewel die gasheerliggaam optimale toestande (temperatuur, lug ens.) bevat om die groei van hierdie twee patogene te promoveer, mag hulle groei beperk word deur die beskikbare voedingstowwe binne die beperkte spasie van die gasheerlong. Dit kan dus redelikerwys afgelei word dat hierdie mikrobes sal deelneem aan kompetisie om territorial domanansie oor die ander uit te oefen. Om hierdie punt in vitro te demonstreer is Pseudomonas selle saam met Cryptococcus selle gekweek oor ‘n seker periode. Gevolglik is gevind dat Cryptococcus selle Pseudomonas selle domineer. Hierdie domineering het gemanifesteer as ‘n beduidende afname (p = 0.05) in die getal Pseudomonas selle oor ‘n tydperk van 24-h. Ten einde te bepaal of die waargeneemde dominering kan wees as gevolg van negatiewe invloed van die Cryptococcus 3-hidroks, National Research Foundation (NRF), NMDS

Published
2016

159. Incidence and course of depression in multiple sclerosis in the multinational BEYOND trial

Author

Schippling, S, O'Connor, P, Knappertz, V, Pohl, C, Bogumil, T, Suarez, G, Cook, S, Filippi, M, Hartung, H P, Comi, G, Jeffery, D R, Kappos, L, Goodin, D S, Arnason, B, Schippling, S, O'Connor, P, Knappertz, V, Pohl, C, Bogumil, T, Suarez, G, Cook, S, Filippi, M, Hartung, H P, Comi, G, Jeffery, D R, Kappos, L, Goodin, D S, and Arnason, B

Abstract

Early experience in MS generated concerns that interferon beta treatment might provoke onset or worsening of depression. The objective of the study was to compare depression incidence in relapsing-remitting MS patients receiving interferon beta-1b (IFNB-1b) or glatiramer acetate (GA) in the BEYOND trial. 891/897 (99 %) of English, French, Spanish and Italian speakers among 2244 patients randomized (2:2:1) to receive either IFNB-1b 500 µg, 250 µg, or GA 20 mg QD for 2-3.5 years submitted Beck Depression Inventory Second Edition (BDI-II) scores at screening and serially thereafter, in which scores ≥14 indicated depression. Baseline BDI-II scores ≥14 were reported in 232/891 patients (26.3 %), with no meaningful difference among the three treatment arms noted at this or at any other time during the study including trial end. Percentages of patients depressed by BDI-II scores deviated little in any arm at any time (IFNB-1b 500 µg: 24.7 %, IFNB-1b 250 µg: 24.4 %, GA: 32.4 %). Antidepressant usage was likewise similar among the three treatment arms (IFNB-1b 500 µg: 33.7 %, IFNB-1b 250 µg: 31.8 %, GA: 28.8 %) as was depression severity and the frequency with which non-blinded treating physicians recorded depression as an adverse event (IFNB-1b 500 µg: 17.2 %, IFNB-1b 250 µg: 17.0 %, GA: 14.4 %). Treating physicians attributed depression to IFNB-1b 250 µg therapy in 53.6 % and to GA in 21.9 % of instances. This large, prospective, randomized-controlled MS dataset showed no increased risk of depression above baseline values with standard or double-dose IFNB-1b or GA QD treatment.

Published
2016

161. FRI0142 High Prevalence of Depression in Patients with Rheumatoid Arthritis - Data from The Large Cross-Sectional Vadera II Study

Author

Englbrecht, M., primary, Alten, R., additional, Aringer, M., additional, Baerwald, C.G., additional, Burkhardt, H., additional, Eby, N., additional, Flacke, J.-P., additional, Fliedner, G., additional, Gauger, B., additional, Henkemeier, U., additional, Hofmann, M.W., additional, Kleinert, S., additional, Kneitz, C., additional, Krüger, K., additional, Lüthje, R., additional, Pohl, C., additional, Schett, G., additional, Schmalzing, M., additional, Tausche, A.-K., additional, Tony, H.P., additional, and Wendler, J., additional

Published
2016
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166. Chronische Chorioretinopathie centralis serosa (CCS): qualitative Analyse der Makularegeneration nach einer Kombination aus photodynamischer Therapie (PDT) und vascular endothelial growth factor (VEGF-) Inhibitoren - Langzeitergebnisse und Rezidivarate

Author

Schnorrenberger, Nora, Kaymak, H., Breyer, D., Klabe, K., and Pohl, C.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: CCS tritt eher selten auf und kommt meist bei jüngeren Männern zwischen 20 und 50 Jahren vor. Die Ursache dafür ist bisher nicht bekannt, erfolgreiche dauerhafte Therapien sind eher dürftig in der Literatur dokumentiert. Die bei einer CCS auftetenden Symptome wie seröse[for full text, please go to the a.m. URL], 176. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte

Published
2014

167. Erste klinische Ergebnisse nach Implantation einer trifokalen torischen Multifokallinse

Author

Breyer, Detlev, Kaymak, H., Klabe, K., and Pohl, C.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Presbyopie und Refraktionsdefizite werden mit Hilfe der Implantation MIOL behandelt. Nachteile der bisherigen Generation von diffraktiven bifokalen MIOL sind nur zwei effektiv nutzbare Entfernungen (Ferne und Nähe oder Intermediärvisus) und mögliche photopische Phänomene[for full text, please go to the a.m. URL], 176. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte

Published
2014

168. Sonderlinsen für den Hinterabschnittschirurgen?

Author

Kaymak, Hakan, Breyer, D., Klabe, K., and Pohl, C.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Verkippung und Dezentrierung von asphärischen Intraokularlinsen (AIOL), Rotation torischer IOL (TIOL) und die performance einer multifokalen IOL (MIOL) sind in Kombination mit Vitrektomien bisher nicht untersucht worden. Hier präsentieren wir unsere ersten Ergebnisse nach Implantation[for full text, please go to the a.m. URL], 28. Kongress der Deutschsprachigen Gesellschaft für Intraokularlinsen-Implantation, Interventionelle und Refraktive Chirurgie (DGII)

Published
2014
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169. Multifokalität durch IOL-Kombination: Vergleich von verschiedenen Intraokularlinsen (IOL)-Kombinationen bezüglich Refraktion, Sehschärfe und Defokuskapazität

Author

Pohl, C, Breyer, D, Kaymak, H, and Klabe, K

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Aufgrund der unterschiedlichen optischen Architektur aktueller MIOL weichen Parameter wie Kontrastsehen, Intermediärdistanzoptima sowie Photopsien z.T. erheblich voneinander ab. Die vorliegende Untersuchung befasst sich mit einem Vergleich von zwei multifokalen IOL (MIOL-) Kombinationen,[for full text, please go to the a.m. URL], 27. Internationaler Kongress der Deutschen Ophthalmochirurgen

Published
2014
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170. Rotationsstabilität torischer Intraokularlinsen nach pars plana Vitrektomie

Author

Kaymak, H, Breyer, D, Klabe, K, and Pohl, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Pars plana Vitrektomien werden häufig zeitlich nah mit Katarakt-Operationen durchgeführt. Dabei kann es theoretisch zur Verkippung, Dezentrierung bzw. Rotation der implantierten Linse kommen. Diese Veränderung ist besonders heikel bei torischen Linsen, deren exakte Positionierung[for full text, please go to the a.m. URL], 176. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte

Published
2014
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171. Vitreomakuläre Traktion (VMT): Erste klinische Ergebnisse nach Ocriplasmin-Injektion

Author

Klabe, K, Kaymak, H, Breyer, D, and Pohl, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Zielsetzung: Auf die Diagnose einer VMT folgte in der Vergangenheit meist eine Glaskörperentfernung. Seit Beginn 2013 steht mit einem rekombinant hergestelltem Derivat von Plasmin (Ocriplasmin) ein Medikament zur Lösung der Traktion als Alternativtherapie zur Verfügung. Wir präsentieren[for full text, please go to the a.m. URL], 27. Jahrestagung der Retinologischen Gesellschaft

Published
2014
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172. Vergleich von Femto-LASIK und small incision lenticule extraction (SMILE, mit 2 verschiedenen Ablationsmustern)

Author

Breyer, D, Kaymak, H, Klabe, K, Dillner, F, and Pohl, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Bisher trat eine verzögerte Visuserholung bei der SMILE-Methode im Vergleich zur Femto-LASIK auf. Sicherheit, Effizienz & Sehschärfe zeigten keine Nachteile im Vergleich zur Femto-LASIK. Wie fallen die Ergebnisse mit einem neuen Ablationsmuster bei der SMILE-Methode im [for full text, please go to the a.m. URL], 28. Kongress der Deutschsprachigen Gesellschaft für Intraokularlinsen-Implantation, Interventionelle und Refraktive Chirurgie (DGII)

Published
2014
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173. Vitreomakuläre Traktion (VMT): Erste klinische Ergebnisse nach Ocriplasmin-Injektion

Author

Fulga, R, Kaymak, H, Breyer, D, Klabe, K, and Pohl, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Zielsetzung: Auf die Diagnose einer VMT folgte in der Vergangenheit meist eine Glaskörperentfernung. Seit Beginn 2013 steht mit einem rekombinant hergestelltem Derivat von Plasmin (Ocriplasmin) ein Medikament zur Lösung der Traktion als Alternativtherapie zur Verfügung. Wir präsentieren[for full text, please go to the a.m. URL], 27. Internationaler Kongress der Deutschen Ophthalmochirurgen

Published
2014
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174. Funktionelle Ergebnisse nach Implantation von Multifokallinsen (MIOL) der neuesten Generation: Alcon IQ Restor und CZM LISA

Author

Bhakdi-Gerl, V, Kaymak, H, Breyer, D, Klabe, K, and Pohl, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Das schnell wachsende Spektrum der multifokalen Intraokularlinsen (MIOL) ermöglicht eine bessere Anpassung in die individuellen Patientenbedürfnisse. Die aktuelle MIOL Generation verspricht erhöhte Lichttransmission bei verschiedenen Pupillenweiten sowie Visusverbesserung[for full text, please go to the a.m. URL], 176. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte

Published
2014
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175. Kapazität von rotationsassymmetrischen Multifokallinsen (MIOL) – Vergleich von Visusergebnissen mit Defokuskurven zweier refraktiver MIOL mit verschiedenen Additionen (P1)

Author

Pohl, C, Breyer, D, Kaymak, H, and Klabe, K

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Aufgrund der unterschiedlichen optischen Architektur aktueller MIOL weichen Parameter wie Kontrastsehen, Intermediärdistanzoptima sowie Photopsien z.T. erheblich voneinander ab. Die vorliegende Untersuchung befasst sich mit einem Vergleich von zwei refraktiven MIOL (Oculentis), die[for full text, please go to the a.m. URL], 27. Internationaler Kongress der Deutschen Ophthalmochirurgen

Published
2014
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176. Vergleich von optischer Abbildungsqualität, Effektivität und Sicherheit bei Femto-LASIK und small incision lenticule extraction (SMILE, mit 2 verschiedenen Ablationsmustern)

Author

Pohl, C, Breyer, D, Kaymak, H, and Klabe, K

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Bisherige Analysen ergaben eine etwas verzögerte Visuserholung bei der SMILE-Methode im Vergleich zur traditionallen Femto-LASIK.Parameter wie Sicherheit, Effizienz und Sehschärfe zeigten keinerlei Nachteile im Vergleich zur Femto-LASIK. Wie fallen die Ergebnisse mit einem neuen[for full text, please go to the a.m. URL], 176. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte

Published
2014
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180. Funktionelle Ergebnisse nach Implantation von Multifokallinsen der neuesten Generation: Alcon IQ Restor 2.5 vs. CZM Lisatri 839

Author

Kaymak, Hakan, Breyer, D., Klabe, K., Dillner, F., and Pohl, C.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Aufgrund verstärkter Nachfrage entwickeln Hersteller Multifokallinsen (MIOL), die das Lesen im Intermediärbereich, z.B. am PC, ermöglichen. Methodik: Retrospektiv wurden je 20 Augen postoperativ nach Implantation einer MIOL ausgewertet. Untersucht wurden prä-[for full text, please go to the a.m. URL], 27. Kongress der Deutschsprachigen Gesellschaft für Intraokularlinsen-Implantation, Interventionelle und Refraktive Chirurgie (DGII)

Published
2013

181. Rotationsstabilität torischer Linsen bei Pars plana Vitrektomien

Author

Dillner, Franziska, Kaymak, H., Breyer, D., Klabe, K., and Pohl, C.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: In der modernen Augenchirurgie ist die Implantation von Astigmatismus korrgierenden Linsen ein Standardverfahren. Besonders wichtig ist die Aufrechterhaltung der Position dieser torischen Linsen nach erfolgter Implantation. Bisher ist unbekannt, wie sich die Rotation torischer Linsen nach[for full text, please go to the a.m. URL], 175. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte

Published
2013
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182. Optimierung der MIOL-Wahl: Kann die Defokuskurve als geeignetes Auswahlkriterium dienen? (P1)

Author

Breyer, D, Kaymak, H, Klabe, K, and Pohl, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Zielsetzung: Die neueste Generation von MIOL erweitert das aktuelle IOL-Spektrum erheblich. Jede dieser neuen MIOL divergiert in optischen Eigenschaften und Lichtverteilungen, die eine bedachte Auswahl seitens des Chirurgen erfordert. Ist die Defokuskurve ein geeignetes Auswahlkriterium? Methode:[for full text, please go to the a.m. URL], 26. Internationaler Kongress der Deutschen Ophthalmochirurgen

Published
2013
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183. Chorioretinopathia centralis serosa: Ergebnisse nach Behandlung mit einer Kombination aus photodynamischer Therapie (PDT) und VGEF-Inhibitoren

Author

Kaymak, H, Breyer, D, Klabe, K, and Pohl, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Chorioretinopathia centralis serosa kann enorme Visuseinschränkungen auslösen. Oft treten Begleiterscheinungen wie ein Makulaödem auf. Wir berichten von Patienten (männlich und weiblich) die eine Kombination aus photodynamischer Therapie und VGEF-Inhibitoren erhalten[for full text, please go to the a.m. URL], 175. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte

Published
2013
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184. Chronische Chorioretinopathie centralis serosa (CCS): Qualitative Analyse der Makularegeneration nach einer Kombination aus photodynamischer Therapie (PDT) und vascular endothelial growth factor (VEGF-) Inhibitoren (K)

Author

Dillner, F, Kaymak, H, Breyer, D, Klabe, K, and Pohl, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Zielsetzung: CCS tritt eher selten auf und kommt meist bei jüngeren Männern zwischen 20 und 50 Jahren vor. Die Ursache dafür ist bisher nicht bekannt, erfolgreiche dauerhafte Therapien sind eher dürftig in der Literatur dokumentiert. Die bei einer CCS auftetenden Symptome wie seröse[for full text, please go to the a.m. URL], 26. Internationaler Kongress der Deutschen Ophthalmochirurgen

Published
2013
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185. Vergleich von optischer Abbildungsqualität bei intraokular Linsen (IOL) nach entweder manueller oder Femtosekundenlaser (Fs)-basierter (FLACS) Kapsulorhexis (CCC) (P1)

Author

Breyer, D, Kaymak, H, Klabe, K, and Pohl, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Zielsetzung: Die Einführung von Fs-basierter Kapsulorhexis repräsentiert einen Fortschritt bezüglich Präzision und Wiederholbarkeit in der Kataraktchirurgie. Wichtige Parameter, wie z.B. effektive Linsenpositionierung könnten durch die neue Technik eine Verbesserung zeigen. [for full text, please go to the a.m. URL], 26. Internationaler Kongress der Deutschen Ophthalmochirurgen

Published
2013
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186. Rotationsstabilität torischer Intraokularlinsen nach 23 gauge pars plana Vitrektomie (K)

Author

Kaymak, H, Breyer, D, Klabe, K, and Pohl, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Zielsetzung: Pars plana Vitrektomien werden häufig zeitlich nah mit Katarakt-Operationen durchgeführt. Dabei kann es theoretisch zur Verkippung, Dezentrierung bzw. Rotation der implantierten Linse kommen. Diese Veränderung ist besonders heikel bei torischen Linsen, deren exakte Positionierung[for full text, please go to the a.m. URL], 26. Internationaler Kongress der Deutschen Ophthalmochirurgen

Published
2013
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187. Implantation einer intracornealen Mikrolinse – erste Ergebnisse (P1)

Author

Dillner, F, Breyer, D, Kaymak, H, Klabe, K, and Pohl, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Zielsetzung: Presbyopie kann mit mehreren Corneaimplantaten behandelt werden. Wir repräsentieren erste Ergebnisse nach Implantation einer nicht-refraktiven, transparenten Microlinse. Methode: Anhand von drei Fallbeispielen präsentieren wir Auswertungen von Aberrometrie (iTrace und TOPCON),[for full text, please go to the a.m. URL], 26. Internationaler Kongress der Deutschen Ophthalmochirurgen

Published
2013
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188. Rotational stability of toric lenses with 23-gauge pars plana vitrectomy (PPV)

Author

Kaymak, H, Breyer, D, Klabe, K, and Pohl, C

Subjects
ddc: 610, genetic structures, 610 Medical sciences, Medicine, eye diseases
Abstract

PPV surgeries are often combined with cataract surgery. Since the exact positioning of toric lenses is a delicate matter to good visual outcome, simultaneous as well as temporal closely adjacent PPV surgery represents an additional factor to be considered in functional outcome of toric lens implantation.[for full text, please go to the a.m. URL], 26. Jahrestagung der Retinologischen Gesellschaft

Published
2013
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189. Erste klinische Ergebnisse nach Implantation einer trifokalen IOL

Author

Hennen, M, Breyer, D, Kaymak, H, Pohl, C, and Dillner, F

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Presbyopie und Refraktionsdefizite werden bereits erfolgreich mit Hilfe der Implantation multifokaler IOLs (MIOL) in der Katarakt-Chirurgie behandelt. Nachteile dieser „bifokalen“ IOLs sind nur zwei effektiv nutzbare Entfernungen (Ferne und Nähe oder Intermediärvisus)[for full text, please go to the a.m. URL], 175. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte

Published
2013
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190. Balanced Leave-One-Subject-Out Cross- Validation for Microsleep Classification

Author

Pauli Martin Patrick, Pohl Constantin, and Golz Martin

Subjects
electroencephalogram, microsleep, machine learning, cross validation, gradient boosting machine, Medicine
Abstract

Inter-individual differences in the feature distribution of electroencephalograms (EEG) during microsleep (MS) raise questions about the generalizability of the methodology, because methodology should have the same validity for subjects to be included in the analysis in the future as for subjects included so far. We address this question using leave-one-subject- out cross-validation (LOSO CV) to simulate inclusion of test data from future subjects. Investigations are based on EEG of 70 subjects across four studies conducted in our driving simulation lab. 9,297 MS and 10,264 counter-examples of sustained attention (SA) were included in the analysis. Three variants of sample balancing are compared: (1) none, (2) overall balancing, and (3) between-subjects balancing. Resulting classification accuracies range from 80% to 100% for 67 subjects, but for 3 subjects they are at 66.5%, 73.1%, 78.3%. Averaged across subjects, accuracies were (1) 90.2%, (2) 90.2% and (3) 89.1%. Thus, balancing might not be essential if LOSO CV is performed over a sufficiently large number of subjects. Results of standard CV must be regarded as optimistically biased.

Published
2021
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193. Computer Code System V. S. O. P. (99/11) Update 2011 of V.S.O.P(99)-Version 2009 CODE MANUAL

Author

Rütten, H. J., Haas, K. A., and Pohl, C.

Subjects
Physics::Chemical Physics, Physics::Geophysics
Abstract

V.S.O.P. is a computer code system for the comprehensive numerical simulation of the physics of thermal reactors. The application of the code implies processing of cross sections, the set-up of the reactor and of the fuel element, neutron spectrum evaluation, neutron diffusion calculation, fuel burnup, fuel shuffling, reactor control, and thermal hydraulics of steady states and transients. The neutronics calculations can be performed in up to three dimensions. Thermal hydraulics is restricted to gas-cooled reactors in two spatial dimensions. Evaluation of fuel cycle costs over the reactor life time is made using the present worth method. A broad description of the features of the code has been published in Ref. /1/.

Published
2012

198. New MAbPac Phases for Monoclonal Antibody (MAb) Variant Analysis

Author

Rao, S., Hou, Y.X., Liu, X., Agroskin, Y., Pohl, C., and Gendeh, G.

Subjects
Poster Session Abstracts
Abstract

MAbs generally exhibit complex heterogeneity including glycosylation, oxidation, phosphorylation, amino-terminal modifications, incomplete processing of the C-terminus, and asparagine deamidation. These variations in composition could impact their efficacy, stability, and safety. Monitoring and reporting such variations in therapeutic proteins is required by the FDA and other regulatory agencies. Two new MAbPac™ phases were developed to meet these needs. The MAbPac SCX-10 is a newly designed strong cation-exchange column for the characterization of heterogeneity of MAbs. This is a complementary addition to the existing ProPac® WCX-10 column that provides high resolution and orthogonal selectivity for MAb charge variant analysis. The MAbPac SCX stationary phase is based on nonporous, highly cross-linked styrenic type polymeric media with a proprietary hydrophilic coating. Sulfonic acid functionality is added through controlled radical polymerization grafting. These particles exhibit a wide range of pH stability with high selectivity and minimal band spreading. The MAbPac SEC-1 is a new size-exclusion chromatography (SEC) column specifically developed for characterization of monoclonal antibody (MAb) aggregates, enzyme digested fragments, and other size-based separation applications. The MAbPac SEC column is based on high-purity, spherical, porous (300 A), 5 μm silica covalently modified with a proprietary diol hydrophilic layer. This stationary phase can handle both high- and low- salt eluents as well as mass spectrometry compatible eluents. The MAbPac column is packed into a nonmetallic, biocompatible PEEKTM column housing to eliminate metal contamination from the column hardware that can compromise MAb separations. The stationary phase is designed to minimize undesired nonspecific interactions between proteins and the stationary phase. Various applications with relevant comparisons along with a demonstration of the ruggedness of these new phases are shown in this poster.

Published
2011

199. Prognostic implications of a carefully performed neurological assessment in patients with a first event suggestive of multiple sclerosis (vol 9, pg 19, 2009)

Author

Nielsen, J.M., Pohl, C., Polman, C.H., Barkhof, F., Freedman, M.S., Edan, G., Miller, D. H., Bauer, L., Sandbrink, R., Kappos, L., Uitdehaag, B.M.J., Neurology, Radiology and nuclear medicine, Epidemiology and Data Science, and NCA - Multiple Sclerosis and Other Neuroinflammatory Diseases

Published
2011
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200. Aminoacyl-tRNA-charged eukaryotic elongation factor 1A is the bona fide substrate for Legionella pneumophila effector glucosyltransferases

Author

Tzivelekidis, T., Jank, T., Pohl, C., Schlosser, A., Rospert, S., Knudsen, C., Rodnina, M., Belyi, Y., and Aktories, K.

Subjects
Models, Molecular, Bacterial Diseases, Glycosylation, Gene Expression, Legionella, lcsh:Medicine, Protein Synthesis, RNA, Transfer, Amino Acyl, Biochemistry, Microbiology, Cell Line, Legionella pneumophila, Substrate Specificity, Mice, Adenosine Triphosphate, Peptide Elongation Factor 1, Tandem Mass Spectrometry, Molecular Cell Biology, Animals, Amino Acid Sequence, Cloning, Molecular, lcsh:Science, Biology, Microbial Pathogens, Enzyme Classes, Macrophages, lcsh:R, Proteins, Enzymes, Bacterial Pathogens, carbohydrates (lipids), Host-Pathogen Interaction, Infectious Diseases, Glucosyltransferases, Biocatalysis, Medicine, Protein Translation, lcsh:Q, Chromatography, Liquid, Research Article
Abstract

Legionella pneumophila, which is the causative organism of Legionnaireś disease, translocates numerous effector proteins into the host cell cytosol by a type IV secretion system during infection. Among the most potent effector proteins of Legionella are glucosyltransferases (lgt's), which selectively modify eukaryotic elongation factor (eEF) 1A at Ser-53 in the GTP binding domain. Glucosylation results in inhibition of protein synthesis. Here we show that in vitro glucosylation of yeast and mouse eEF1A by Lgt3 in the presence of the factors Phe-tRNA(Phe) and GTP was enhanced 150 and 590-fold, respectively. The glucosylation of eEF1A catalyzed by Lgt1 and 2 was increased about 70-fold. By comparison of uncharged tRNA with two distinct aminoacyl-tRNAs (His-tRNA(His) and Phe-tRNA(Phe)) we could show that aminoacylation is crucial for Lgt-catalyzed glucosylation. Aminoacyl-tRNA had no effect on the enzymatic properties of lgt's and did not enhance the glucosylation rate of eEF1A truncation mutants, consisting of the GTPase domain only or of a 5 kDa peptide covering Ser-53 of eEF1A. Furthermore, binding of aminoacyl-tRNA to eEF1A was not altered by glucosylation. Taken together, our data suggest that the ternary complex, consisting of eEF1A, aminoacyl-tRNA and GTP, is the bona fide substrate for lgt's.

Published
2011

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