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151. Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly

Author

Hartog,Renee, Bolignano,Davide, Sijbrands,Eric, Pucci,Giacomo, Mattace-Raso,Francesco, Hartog,Renee, Bolignano,Davide, Sijbrands,Eric, Pucci,Giacomo, and Mattace-Raso,Francesco

Abstract

Renee Hartog,1,* Davide Bolignano,1,2,* Eric Sijbrands,1 Giacomo Pucci,3,4 Francesco Mattace-Raso1 1Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; 2Institute of Clinical Physiology, Italian National Council of Research, Reggio Calabria, Italy; 3Department of Medicine, University of Perugia, Perugia, Italy; 4Unit of Internal Medicine, Terni University Hospital, Terni, Italy *These authors contributed equally to this work Background: Vascular aging is known to induce progressive stiffening of the large elastic arteries, altering vascular hemodynamics under both rest and stress conditions. In this study, we aimed to investigate changes in vascular hemodynamics in response to isometric handgrip exercise across ages.Participants and methods: We included 62 participants, who were divided into three age categories: 20–40 (n=22), 41–60 (n=20), and 61–80 (n=20) years. Vascular hemodynamics were measured using the Mobil-o-Graph® based on the pulsatile pressure changes in the brachial artery. One-way ANOVA test was performed to analyze the changes induced by isometric handgrip exercise.Results: After isometric handgrip exercise, aortic pulse wave velocity (PWV) increased by 0.10 m/s in the youngest, 0.06 m/s in the middle-age, and 0.02 m/s in the oldest age category. Changes in PWV strongly correlated with those in central systolic blood pressure (cSBP) (r=0.878, P<0.01). After isometric exercise, the mean change of systolic blood pressure (SBP) was -1.9% in the youngest, 0.6% in the middle-aged, and 8.2% in the oldest subjects. Increasing handgrip strength was associated with an increase in SBP and cSBP (1.08 and 1.37 mmHg per 1 kg increase in handgrip strength, respectively, P=0.01). Finally, PWV was significantly associated with increasing handgrip strength with an increase of 0.05 m/s per 1 kg higher handgrip

Published
2018

152. Diagnostic and Therapeutic Approach to Sleep Disorders, High Blood Pressure and Cardiovascular Diseases: A Consensus Document by the Italian Society of Hypertension (SIIA).

Author

Del Pinto, Rita, Grassi, Guido, Ferri, Claudio, Pengo, Martino F., Lombardi, Carolina, Pucci, Giacomo, Salvetti, Massimo, Parati, Gianfranco, SIIA Young Researchers Study Group, Del Pinto, Rita, President of SIIA, Past President of SIIA, Italian Society of Hypertension (SIIA), Muiesan, Maria Lorenza, Sechi, Leonardo, Cicero, Arrigo F. G., Iaccarino, Guido, Minuz, Pietro, Mulatero, Paolo, and Mulè, Giuseppe

Subjects
SLEEP disorder diagnosis, SLEEP disorders treatment, HYPERTENSION, CARDIOVASCULAR diseases risk factors, MEDICAL protocols
Abstract

Hypertension is a major contributor to fatal/nonfatal cardiovascular diseases, and timely identification and appropriate management of factors affecting hypertension and its control are mandatory public health issues. By inducing neurohormonal alterations and metabolic impairment, sleep disorders have an impact on a variety of cardiovascular risk factors, including hypertension, and ultimately increase the risk of cardiovascular events. There is evidence that qualitative and quantitative sleep disorders are associated with resistant hypertension and with impaired circadian blood pressure variations. However, sleep disturbances are often unrecognized, or heterogeneity exists in their management by non-specialists in the field. This document by the Italian Society of Hypertension summarizes the updated evidence linking sleep disorders to hypertension and cardiovascular diseases, the major underlying mechanisms, and the possible management strategies. A simplified, evidence-based diagnostic and therapeutic algorithm for comorbid hypertension and common sleep disorders, namely obstructive sleep apnoea and insomnia, is proposed. [ABSTRACT FROM AUTHOR]

Published
2021
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153. Determinants of healing among patients with coronavirus disease 2019: the results of the SARS-RAS study of the Italian Society of Hypertension.

Author

Mancusi, Costantino, Grassi, Guido, Borghi, Claudio, Carugo, Stefano, Fallo, Francesco, Ferri, Claudio, Giannattasio, Cristina, Grassi, Davide, Letizia, Claudio, Minuz, Pietro, Muiesan, Maria Lorenza, Perlini, Stefano, Pucci, Giacomo, Rizzoni, Damiano, Salvetti, Massimo, Sarzani, Riccardo, Sechi, Leonardo, Veglio, Franco, Volpe, Massimo, and Iaccarino, Guido

Published
2021
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154. Accuracy of Cuff-Measured Blood Pressure: Systematic Reviews and Meta-Analyses

Author

Picone, Dean S., Schultz, Martin G., Otahal, Petr, Aakhus, Svend, Al-Jumaily, Ahmed M., Black, J. Andrew, Bos, Willem J., Chambers, John B., Chen, Chen-Huan, Cheng, Hao-Min, Cremer, Antoine, Davies, Justin E., Dwyer, Nathan, Gould, Brian A., Hughes, Alun D., Lacy, Peter S., Laugesen, Esben, Liang, Fuyou, Melamed, Roman, Muecke, Sandy, Ohte, Nobuyuki, Okada, Sho, Omboni, Stefano, Ott, Christian, Peng, Xiaoqing, Pereira, Telmo, Pucci, Giacomo, Rajani, Ronak, Roberts-Thomson, Philip, Rossen, Niklas B., Sueta, Daisuke, Sinha, Manish D., Schmieder, Roland E., Smulyan, Harold, Srikanth, Velandai K., Stewart, Ralph, Stouffer, George A., Takazawa, Kenji, Wang, Jiguang, Westerhof, Berend E., Weber, Franz, Weber, Thomas, Williams, Bryan, Yamada, Hirotsugu, Yamamoto, Eiichiro, Sharman, James E., Pulmonary medicine, ACS - Pulmonary hypertension & thrombosis, ACS - Atherosclerosis & ischemic syndromes, and ACS - Heart failure & arrhythmias

Subjects
blood pressure determination, Medizin, sphygmomanometers, Reproducibility of Results, Blood Pressure Determination, Blood Pressure, Review, Equipment Design, hemodynamics, Cardiovascular Diseases, Cardiology and Cardiovascular Medicine, Journal Article, Meta-Analysis
Abstract

Background Hypertension (HTN) is the single greatest cardiovascular risk factor worldwide. HTN management is usually guided by brachial cuff blood pressure (BP), but questions have been raised regarding accuracy. Objectives This comprehensive analysis determined the accuracy of cuff BP and the consequent effect on BP classification compared with intra-arterial BP reference standards. Methods Three individual participant data meta-analyses were conducted among studies (from the 1950s to 2016) that measured intra-arterial aortic BP, intra-arterial brachial BP, and cuff BP. Results A total of 74 studies with 3,073 participants were included. Intra-arterial brachial systolic blood pressure (SBP) was higher than aortic values (8.0 mm Hg; 95% confidence interval [CI]: 5.9 to 10.1 mm Hg; p < 0.0001) and intra-arterial brachial diastolic BP was lower than aortic values (−1.0 mm Hg; 95% CI: −2.0 to −0.1 mm Hg; p = 0.038). Cuff BP underestimated intra-arterial brachial SBP (−5.7 mm Hg; 95% CI: −8.0 to −3.5 mm Hg; p < 0.0001) but overestimated intra-arterial diastolic BP (5.5 mm Hg; 95% CI: 3.5 to 7.5 mm Hg; p < 0.0001). Cuff and intra-arterial aortic SBP showed a small mean difference (0.3 mm Hg; 95% CI: −1.5 to 2.1 mm Hg; p = 0.77) but poor agreement (mean absolute difference 8.0 mm Hg; 95% CI: 7.1 to 8.9 mm Hg). Concordance between BP classification using the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure cuff BP (normal, pre-HTN, and HTN stages 1 and 2) compared with intra-arterial brachial BP was 60%, 50%, 53%, and 80%, and using intra-arterial aortic BP was 79%, 57%, 52%, and 76%, respectively. Using revised intra-arterial thresholds based on cuff BP percentile rank, concordance between BP classification using cuff BP compared with intra-arterial brachial BP was 71%, 66%, 52%, and 76%, and using intra-arterial aortic BP was 74%, 61%, 56%, and 65%, respectively. Conclusions Cuff BP has variable accuracy for measuring either brachial or aortic intra-arterial BP, and this adversely influences correct BP classification. These findings indicate that stronger accuracy standards for BP devices may improve cardiovascular risk management.

Published
2017
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155. Frequency of Left Ventricular Hypertrophy in Non-Valvular Atrial Fibrillation

Author

Proietti M, Marra AM, Tassone EJ, De Vuono S, Corrao S, Gobbi P, Perticone F, Corazza GR, Basili S, Lip GY, Violi F, Raparelli V, ARAPACIS Study Investigators, GIS Group, Alessandri Cesare, Serviddio Gaetano, Fascetti Stefano, Serra Pietro, Palange Paolo, Greco Eleonora, Bruno Graziella, Averna Maurizio, Giammanco Antonina, Sposito Pietro, De Cristofaro Raimondo, De Gennaro Leonardo, Loria Paola, Pellegrini Elisa, Cominacini Luciano, Mozzini Chiara, Sprovieri Mario, Spagnuolo Vitaliano, Cerqua Giannantonio, Cerasola Giovanni, Mulé Giuseppe, Barbagallo Mario, Lo Sciuto Salvatore, Monteverde Alfredo, Saitta Antonino, Lo Gullo Alberto, Malatino Lorenzo, Cilia Chiara, Licata Giuseppe, Tuttolomondo Antonino, Conigliaro Roberta, Pinto Antonio, Di Raimondo Domenico, Signorelli Santo, Anzaldi Massimiliano, De Palma Daniela, Galderisi Maurizio, Cudemo Giuseppe, Galletti Ferruccio, Fazio Valeria, De Luca Nicola, Meccariello Alfonso, Caputo Dario, De Donato Maria Teresa, Iannuzi Arcangelo, Bresciani Alessandro, Giunta Riccardo, Cimini Claudia, Durante Mangoni Emanuele, Agrusta Federica, Iorio Federica, Adinolfi Luigi E, Sellitto Ausilia, Restivo Luciano, Bellis Paolo, Tirelli Paolo, Sacerdoti David, Pesce Paola, Vanni Dino, Iuliano Luigi, Ciacciarelli Marco, Pacelli Antonio, Palazzuoli Alberto, Cacciafesta Mauro, Gueli Nicola, Capeci William, Tarquinio Nicola, Pellegrini Francesco, Vincentelli Giovanni Maria, Ravallese Ferdinando, Santini Claudio, Letizia Claudio, Petramala Luigi, Zinnamosca Laura, Cilli Mirella, Savoriti Claudio, Falaschi Paolo, Martocchia Antonio, Stefanelli Manuela, Marigliano Vincenzo, Lo Iacono Cristina, Brusco Simona, Bertazzoni Giuliano, Attalla El Halabieh Elias, Paradiso Michele, Lizzi Eugenio Maria, Timmi Stefano, Battisti Paola, Cerci Sabina, Ciavolella Massimo, Di Veroli Claudio, Malci Francesco, De Ciocchis Anita, Abate Damiano, Castellino Pietro, Curto Irene, Vecchio Claudia, Mannarino Elmo, Pasqualini Leonella, Fattori Chiara, Pende Aldo, Denegri Andrea, Artom Nathan, Ricchio Roberto, Fimognari Filippo Luca, Alletto Maurizio, Messina Simona, Sesti Giorgio, Arturi Franco, Grembiale Alessandro, Perticone Francesco, Maio Raffaele, Scarpino Paola Elisa, Carullo Giuseppe, Sciacqua Angela, Frugiuele Pierluigi, Battaglia Giuseppe, Vidili Gianpaolo, Atzori Sebastiana, Delitala Giuseppe, Davì Giovanni, Angelucci Ermanno, Sestili Simona, Traisci Giancarlo, De Feudis Lucrezia, Di Michele Dario, Fava Alessandra, Balsano Clara, De Ciantis Pierpaolo, Desideri Giovambattista, Camerota Antonio, Migliacci Rino, Porciello Giovanni, Mezzetti Matteo, Gresele Paolo, Vedovati Cristina, Fierro Tiziana, Puccetti Luca, Scarpini Francesca, Bertolotti Marco, Mussi Chiara, Boddi Maria, Savino Andrea, Contri Silvia, Saller Alois, Fabris Fabrizio, Pesavento Raffaele, Filippi Lucia, Vedovetto Valentina, Puato Massimo, Treleani Martina, De Luca Elisabetta, De Zaiacomo Francesca, Giantin Valter, Semplicini Andrea, Minuz Pietro, Calabria Stefano, Romano Simone, Fantin Francesco, Manica Angela, Stockner Ingrid, Pattis Peter, Gutmann Bernhard, Catena Cristiana, Colussi GianLuca, Annoni Giorgio, Bruni Adriana Antonella, Castagna Alberto, Spinelli Diana, Corazza Gino Roberto, Miceli Emanuela, Padula, Schinco Giuseppina, Spreafico Sibilla, Secchi Beatrice, Vanoli Massimo, Casella Gianluca, Serra Maria Grazia, Longo Stefania, Antonaci Salvatore, Belfiore Anna, Ricci Lara, Ventrella Francesco, Iamele Luigi, Bianco Cesare, Santovito Donato, Cipollone Francesco, Nicolai Salvatore, Salvati Filippo, Rini Giovan Battista, Scozzari Francesca, Muiesan Maria Lorenza, Salvetti Massimo, Bazza Abramo, Picardi Antonio, De Vincentis Antonio, Cosio Paolo, Terzolo Massimo, Madaffari Bruno, Parasporo Bruno, Fenoglio Luigi, Bracco Christian, Melchio Remo, Gentili Tamira, Salvi Aldo, Nitti Cinzia, Falsetti L, Gabrielli Armando, Paglione Ivano, Capucci Alessandro, Brambatti Michela, Sparagna Armando, Tirotta Daniela, Andreozzi Paola, Ettorre Evaristo, Viscogliosi Giovanni, Rossi Fanelli Fillippo, Delfino Massimo, Glorioso Nicola, Melis Giada, Marras Gianfranca, Matta Michela, Sacco Andrea, Stellitano Elio, Scordo Anna, Russo Franco, Caruso Assunta Antonietta, Porreca Ettore, Santilli Francesca, Tana Marco, Ferri Claudio, Grassi Davide, Cheli Paola, Portincasa Piero, Muscianisi Giuseppe, Giordani Sara, Stanghellini Vincenzo, Sabbà Carlo, Suppressa Patrizia, Mancuso Gerardo, Bartone Mosè, Calipari Daniela, Arcidiacono Giuseppe, Bellanuova Ignazio, Ferraro Maria, Scalzo Antonio, Marigliano Giampietro, Cozzolino Domenico, Lampitella Antonio, Acri Vera, Galasso Domenico, Mazzei Francesca, Galasso Salvatore, Buratti Alberto, Porta Massimo, Brizzi Maria Felice, Fattorini Annalisa, Sampietro Francesca, D’Angelo Armando, Pala Marco, Fabbian Fabio, Manfredini Roberto, Moroni Carlo, Valente Lucia, Lopreiato Francesco, Parente Fernando, Moia Marco, Braham Simon, Rossi Marco, Pesce Margherita, Gentile Adelina, Catozzo Vania, Di Napoli Mariarosaria, Baciarello Giacinto, Rancan Elena, Ageno Walter, Guasti Luigina, Ciccaglioni Antonio, Negri Silvia, Polselli Marco, Abbate Rosanna, Marcucci Rossella, Cangemi Roberto, Pignataro Francesca Serena, Marco Proietti, Pastori Daniele, Ferro Domenico, Loffredo Lorenzo, Perri Ludovica, Catasca Elisa, Raparelli Valeria, Napoleone Laura, Talerico Giovanni, Calvieri Camilla, Vicario Tommasa, Russo Roberta, Saliola Mirella, Del Ben Maria, Angelico Francesco, Bucci Tommaso, Baratta Francesco, DATA AND SAFETY MONITORING BOARD (DSMB): Vestri Anna Rita, Farcomeni Alessio, Di Tanna Gianluca, STUDY COORDINATORS: Basili Stefania, Davi’ Giovanni, STEERING COMMITTEE OF ARAPACIS STUDY: Violi Francesco, Lip Gregory YH, Hiatt William R, Vestri Anna Rita, Mannucci Pier Mannuccio, Proietti Marco, Bazzini Cristina, Bianchi Paola Ilaria, Boari Benedetta, Buonauro Agostino, Buttà Carmelo, Buzzetti Elena, Carleo Pietro, Carrabba Maria Domenica, Castorani Luigi, Cecchetto Lara, Colombo Barbara Maria, De Giorgi Alfredo, De Vuono Stefano, Del Corso Lisette, Di Giosia Paolo, Falsetti Lorenzo, Forgione Alessandra, Hijazi Daniel, Lorusso Giusi, Marra Alberto Maria, Masala Maristella, Montebianco Abenavoli Ludovico, Murgia Giuseppe, Naccarato Paola, Pattoneri Paolo, Perego Francesca, Pinto Daniela, Pinna Miriam Pretti Vincenzo, Pucci Giacomo, Salinaro Francesco, Sirico Domenico, Tassone Eliezer Joseph, Torres Daniele, Vazzana Natale, Vecchio Claudia Rita, Vitale Francesco, Proietti M, Marra AM, Tassone EJ, De Vuono S, Corrao S, Gobbi P, Perticone F, Corazza GR, Basili S, Lip GY, Violi F, Raparelli V, ARAPACIS Study Investigators, GIS Group, Alessandri Cesare, Serviddio Gaetano, Fascetti Stefano, Serra Pietro, Palange Paolo, Greco Eleonora, Bruno Graziella, Averna Maurizio, Giammanco Antonina, Sposito Pietro, De Cristofaro Raimondo, De Gennaro Leonardo, Loria Paola, Pellegrini Elisa, Cominacini Luciano, Mozzini Chiara, Sprovieri Mario, Spagnuolo Vitaliano, Cerqua Giannantonio, Cerasola Giovanni, Mulé Giuseppe, Barbagallo Mario, Lo Sciuto Salvatore, Monteverde Alfredo, Saitta Antonino, Lo Gullo Alberto, Malatino Lorenzo, Cilia Chiara, Licata Giuseppe, Tuttolomondo Antonino, Conigliaro Roberta, Pinto Antonio, Di Raimondo Domenico, Signorelli Santo, Anzaldi Massimiliano, De Palma Daniela, Galderisi Maurizio, Cudemo Giuseppe, Galletti Ferruccio, Fazio Valeria, De Luca Nicola, Meccariello Alfonso, Caputo Dario, De Donato Maria Teresa, Iannuzi Arcangelo, Bresciani Alessandro, Giunta Riccardo, Cimini Claudia, Durante Mangoni Emanuele, Agrusta Federica, Iorio Federica, Adinolfi Luigi E, Sellitto Ausilia, Restivo Luciano, Bellis Paolo, Tirelli Paolo, Sacerdoti David, Pesce Paola, Vanni Dino, Iuliano Luigi, Ciacciarelli Marco, Pacelli Antonio, Palazzuoli Alberto, Cacciafesta Mauro, Gueli Nicola, Capeci William, Tarquinio Nicola, Pellegrini Francesco, Vincentelli Giovanni Maria, Ravallese Ferdinando, Santini Claudio, Letizia Claudio, Petramala Luigi, Zinnamosca Laura, Cilli Mirella, Savoriti Claudio, Falaschi Paolo, Martocchia Antonio, Stefanelli Manuela, Marigliano Vincenzo, Lo Iacono Cristina, Brusco Simona, Bertazzoni Giuliano, Attalla El Halabieh Elias, Paradiso Michele, Lizzi Eugenio Maria, Timmi Stefano, Battisti Paola, Cerci Sabina, Ciavolella Massimo, Di Veroli Claudio, Malci Francesco, De Ciocchis Anita, Abate Damiano, Castellino Pietro, Curto Irene, Vecchio Claudia, Mannarino Elmo, Pasqualini Leonella, Fattori Chiara, Pende Aldo, Denegri Andrea, Artom Nathan, Ricchio Roberto, Fimognari Filippo Luca, Alletto Maurizio, Messina Simona, Sesti Giorgio, Arturi Franco, Grembiale Alessandro, Perticone Francesco, Maio Raffaele, Scarpino Paola Elisa, Carullo Giuseppe, Sciacqua Angela, Frugiuele Pierluigi, Spagnuolo Vitaliano, Battaglia Giuseppe, Vidili Gianpaolo, Atzori Sebastiana, Delitala Giuseppe, Davì Giovanni, Angelucci Ermanno, Sestili Simona, Traisci Giancarlo, De Feudis Lucrezia, Di Michele Dario, Fava Alessandra, Balsano Clara, De Ciantis Pierpaolo, Desideri Giovambattista, Camerota Antonio, Migliacci Rino, Porciello Giovanni, Mezzetti Matteo, Gresele Paolo, Vedovati Cristina, Fierro Tiziana, Puccetti Luca, Scarpini Francesca, Bertolotti Marco, Mussi Chiara, Boddi Maria, Savino Andrea, Contri Silvia, Saller Alois, Fabris Fabrizio, Pesavento Raffaele, Filippi Lucia, Vedovetto Valentina, Puato Massimo, Fabris Fabrizio, Treleani Martina, De Luca Elisabetta, De Zaiacomo Francesca, Giantin Valter, Semplicini Andrea, Minuz Pietro, Calabria Stefano, Romano Simone, Fantin Francesco, Manica Angela, Stockner Ingrid, Pattis Peter, Gutmann Bernhard, Catena Cristiana, Colussi GianLuca, Annoni Giorgio, Bruni Adriana Antonella, Castagna Alberto, Spinelli Diana, Corazza Gino Roberto, Miceli Emanuela, Padula, Schinco Giuseppina, Spreafico Sibilla, Secchi Beatrice, Vanoli Massimo, Casella Gianluca, Serra Maria Grazia, Longo Stefania, Antonaci Salvatore, Belfiore Anna, Ricci Lara, Ventrella Francesco, Iamele Luigi, Bianco Cesare, Santovito Donato, Cipollone Francesco, Nicolai Salvatore, Salvati Filippo, Rini Giovan Battista, Scozzari Francesca, Muiesan Maria Lorenza, Salvetti Massimo, Bazza Abramo, Picardi Antonio, De Vincentis Antonio, Cosio Paolo, Terzolo Massimo, Madaffari Bruno, Parasporo Bruno, Fenoglio Luigi, Bracco Christian, Melchio Remo, Gentili Tamira, Salvi Aldo, Nitti Cinzia, Falsetti L, Gabrielli Armando, Paglione Ivano, Capucci Alessandro, Brambatti Michela, Sparagna Armando, Tirotta Daniela, Andreozzi Paola, Ettorre Evaristo, Viscogliosi Giovanni, Rossi Fanelli Fillippo, Delfino Massimo, Glorioso Nicola, Melis Giada, Marras Gianfranca, Matta Michela, Sacco Andrea, Stellitano Elio, Scordo Anna, Russo Franco, Caruso Assunta Antonietta, Porreca Ettore, Santilli Francesca, Tana Marco, Ferri Claudio, Grassi Davide, Cheli Paola, Portincasa Piero, Muscianisi Giuseppe, Giordani Sara, Stanghellini Vincenzo, Sabbà Carlo, Suppressa Patrizia, Mancuso Gerardo, Bartone Mosè, Calipari Daniela, Arcidiacono Giuseppe, Bellanuova Ignazio, Ferraro Maria, Scalzo Antonio, Marigliano Giampietro, Cozzolino Domenico, Lampitella Antonio, Acri Vera, Galasso Domenico, Mazzei Francesca, Galasso Salvatore, Buratti Alberto, Porta Massimo, Brizzi Maria Felice, Fattorini Annalisa, Sampietro Francesca, D’Angelo Armando, Pala Marco, Fabbian Fabio, Manfredini Roberto, Moroni Carlo, Valente Lucia, Lopreiato Francesco, Parente Fernando, Moia Marco, Braham Simon, Rossi Marco, Pesce Margherita, Gentile Adelina, Catozzo Vania, Di Napoli Mariarosaria, Baciarello Giacinto, Rancan Elena, Ageno Walter, Guasti Luigina, Ciccaglioni Antonio, Negri Silvia, Polselli Marco, Abbate Rosanna, Marcucci Rossella, Cangemi Roberto, Pignataro Francesca Serena, Marco Proietti, Pastori Daniele, Ferro Domenico, Loffredo Lorenzo, Perri Ludovica, Catasca Elisa, Raparelli Valeria, Napoleone Laura, Talerico Giovanni, Calvieri Camilla, Vicario Tommasa, Russo Roberta, Saliola Mirella, Del Ben Maria, Angelico Francesco, Bucci Tommaso, Baratta Francesco, DATA AND SAFETY MONITORING BOARD (DSMB): Vestri Anna Rita, Farcomeni Alessio, Di Tanna Gianluca, STUDY COORDINATORS: Basili Stefania, Davi’ Giovanni, STEERING COMMITTEE OF ARAPACIS STUDY: Violi Francesco, Perticone Francesco, Lip Gregory YH, Hiatt William R, Vestri Anna Rita, Corazza Gino Roberto, Mannucci Pier Mannuccio, Licata Giuseppe, Moroni Carlo, Proietti Marco, Anzaldi Massimiliano, Bazzini Cristina, Bianchi Paola Ilaria, Boari Benedetta, Bracco Christian, Buonauro Agostino, Buttà Carmelo, Buzzetti Elena, Calabria Stefano, Capeci William, Carleo Pietro, Carrabba Maria Domenica, Castorani Luigi, Cecchetto Lara, Cimini Claudia, Colombo Barbara Maria, De Giorgi Alfredo, De Vuono Stefano, Denegri Andrea, Del Corso Lisette, Di Giosia Paolo, Durante Mangoni Emanuele, Falsetti Lorenzo, Forgione Alessandra, Grassi Davide, Grembiale Alessandro, Hijazi Daniel, Iamele Luigi, Lorusso Giusi, Marra Alberto Maria, Masala Maristella, Montebianco Abenavoli Ludovico, Murgia Giuseppe, Naccarato Paola, Pattoneri Paolo, Perego Francesca, Pesce Paola, Petramala Luigi, Pinto Daniela, Pinna Miriam Pretti Vincenzo, Pucci Giacomo, Raparelli Valeria, Salinaro Francesco, Santilli Francesca, Scarpini Francesca, Sirico Domenico, Suppressa Patrizia, Tassone Eliezer Joseph, Torres Daniele, Vazzana Natale, Vecchio Claudia Rita, Vidili Gianpaolo, Vitale Francesco, Proietti, M., Marra, A., Tassone, E., De Vuono, S., Corrao, S., Gobbi, P., Perticone, F., Corazza, G., Basili, S., Lip, G., Violi, F., Raparelli, V., Marra, A. M., Tassone, E. J., Corazza, G. R., and Lip, G. Y. H.

Subjects
Registrie, Male, Cross-sectional study, Myocardial Infarction, Longitudinal Studie, Left ventricular hypertrophy, Cohort Studies, non-valvular atrial fibrillation, Atrial Fibrillation, 80 and over, Prevalence, echocardiography, Myocardial infarction, Longitudinal Studies, Prospective Studies, Registries, Prospective cohort study, Ultrasonography, Aged, 80 and over, education.field_of_study, Medicine (all), Atrial fibrillation, Diabetes Mellitu, Middle Aged, Left Ventricular, left ventricular hypertrophy, Italy, Hypertension, Cardiology, Age Distribution, Aged, Ankle Brachial Index, Cross-Sectional Studies, Diabetes Mellitus, Female, Humans, Hypertrophy, Left Ventricular, Logistic Models, Peripheral Arterial Disease, Cardiology and Cardiovascular Medicine, Human, medicine.medical_specialty, Logistic Model, Population, Concentric hypertrophy, Socio-culturale, non-valvular atrial fibrillation, left ventricular hypertrophy, echocardiography, cardiovascular diseases, Internal medicine, medicine, cardiovascular diseases, education, Cross-Sectional Studie, business.industry, Odds ratio, Hypertrophy, medicine.disease, Prospective Studie, Cohort Studie, business
Abstract

Left ventricular hypertrophy (LVH) is significantly related to adverse clinical outcomes in patients at high risk of cardiovascular events. In patients with atrial fibrillation (AF), data on LVH, that is, prevalence and determinants, are inconsistent mainly because of different definitions and heterogeneity of study populations. We determined echocardiographic-based LVH prevalence and clinical factors independently associated with its development in a prospective cohort of patients with non-valvular (NV) AF. From the "Atrial Fibrillation Registry for Ankle-brachial Index Prevalence Assessment: Collaborative Italian Study" (ARAPACIS) population, 1,184 patients with NVAF (mean age 72 ± 11 years; 56% men) with complete data to define LVH were selected. ARAPACIS is a multicenter, observational, prospective, longitudinal on-going study designed to estimate prevalence of peripheral artery disease in patients with NVAF. We found a high prevalence of LVH (52%) in patients with NVAF. Compared to those without LVH, patients with AF with LVH were older and had a higher prevalence of hypertension, diabetes, and previous myocardial infarction (MI). A higher prevalence of ankle-brachial index ≤0.90 was seen in patients with LVH (22 vs 17%, p = 0.0392). Patients with LVH were at significantly higher thromboembolic risk, with CHA2DS2-VASc ≥2 seen in 93% of LVH and in 73% of patients without LVH (p

Published
2015
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156. How to check whether a blood pressure monitor has been properly validated for accuracy.

Author

Picone, Dean S., Padwal, Raj, Campbell, Norm R. C., Boutouyrie, Pierre, Brady, Tammy M., Olsen, Michael Hecht, Delles, Christian, Lombardi, Cintia, Mahmud, Azra, Meng, Yaxing, Mokwatsi, Gontse G., Ordunez, Pedro, Phan, Hoang T., Pucci, Giacomo, Schutte, Aletta E., Sung, Ki‐Chul, Zhang, Xin‐Hua, and Sharman, James E.

Abstract

Hypertension guidelines recommend that blood pressure (BP) should be measured using a monitor that has passed validation testing for accuracy. BP monitors that have not undergone rigorous validation testing can still be cleared by regulatory authorities for marketing and sale. This is the situation for most BP monitors worldwide. Thus, consumers (patients, health professionals, procurement officers, and general public) may unwittingly purchase BP monitors that are non‐validated and more likely to be inaccurate. Without prior knowledge of these issues, it is extremely difficult for consumers to distinguish validated from non‐validated BP monitors. For the above reasons, the aim of this paper is to provide consumers guidance on how to check whether a BP monitor has been properly validated for accuracy. The process involves making an online search of listings of BP monitors that have been assessed for validation status. Only those monitors that have been properly validated are recommended for BP measurement. There are numerous different online listings of BP monitors, several are country‐specific and two are general (international) listings. Because monitors can be marketed using alternative model names in different countries, if a monitor is not found on one listing, it may be worthwhile cross‐checking with a different listing. This information is widely relevant to anyone seeking to purchase a home, clinic, or ambulatory BP monitor, including individual consumers for use personally or policy makers and those procuring monitors for use in healthcare systems, and retailers looking to stock only validated BP monitors. [ABSTRACT FROM AUTHOR]

Published
2020
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157. Gender differences in predictors of intensive care units admission among COVID-19 patients: The results of the SARS-RAS study of the Italian Society of Hypertension.

Author

Iaccarino, Guido, Grassi, Guido, Borghi, Claudio, Carugo, Stefano, Fallo, Francesco, Ferri, Claudio, Giannattasio, Cristina, Grassi, Davide, Letizia, Claudio, Mancusi, Costantino, Minuz, Pietro, Perlini, Stefano, Pucci, Giacomo, Rizzoni, Damiano, Salvetti, Massimo, Sarzani, Riccardo, Sechi, Leonardo, Veglio, Franco, Volpe, Massimo, and Muiesan, Maria Lorenza

Subjects
INTENSIVE care units, COVID-19, COVID-19 pandemic, COMORBIDITY, CHRONIC kidney failure
Abstract

Background: The global rate of intensive care unit (ICU) admission during the COVID-19 pandemic varies within countries and is among the main challenges for health care systems worldwide. Conflicting results have been reported about the response to coronavirus infection and COVID-19 outcomes in men and women. Understanding predictors of intensive care unit admission might be of help for future planning and management of the disease. Methods and findings: We designed a cross-sectional observational multicenter nationwide survey in Italy to understand gender-related clinical predictors of ICU admission in patients with COVID-19. We analyzed information from 2378 charts of Italian patients certified for COVID-19 admitted in 26 hospitals. Three hundred ninety-five patients (16.6%) required ICU admission due to COVID19 infection, more frequently men (74%), with a higher prevalence of comorbidities (1,78±0,06 vs 1,54±0,03 p<0.05). In multivariable regression model main predictors of admission to ICU are male gender (OR 1,74 95% CI 1,36–2,22 p<0.0001) and presence of obesity (OR 2,88 95% CI 2,03–4,07 p<0.0001), chronic kidney disease (OR: 1,588; 95%, 1,036–2,434 p<0,05) and hypertension (OR: 1,314; 95% 1,039–1,662; p<0,05). In gender specific analysis, obesity, chronic kidney disease and hypertension are associated with higher rate of admission to ICU among men, whereas in women, obesity (OR: 2,564; 95% CI 1,336–4.920 p<0.0001) and heart failure (OR: 1,775 95% CI: 1,030–3,057) are associated with higher rate of ICU admission. Conclusions: Our study demonstrates that gender is the primary determinant of the disease's severity among COVID-19. Obesity is the condition more often observed among those admitted to ICU within both genders. Trial registration: Clinicaltrials.gov: NCT04331574. [ABSTRACT FROM AUTHOR]

Published
2020
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158. MASked-unconTrolled hypERtension management based on office BP or on ambulatory blood pressure measurement (MASTER) Study: a randomised controlled trial protocol

Author

Parati, Gianfranco, primary, Agabiti-Rosei, Enrico, additional, Bakris, George L, additional, Bilo, Grzegorz, additional, Branzi, Giovanna, additional, Cecchi, Franco, additional, Chrostowska, Marzena, additional, De la Sierra, Alejandro, additional, Domenech, Monica, additional, Dorobantu, Maria, additional, Faria, Thays, additional, Huo, Yong, additional, Jelaković, Bojan, additional, Kahan, Thomas, additional, Konradi, Alexandra, additional, Laurent, Stéphane, additional, Li, Nanfang, additional, Madan, Kushal, additional, Mancia, Giuseppe, additional, McManus, Richard J, additional, Modesti, Pietro Amedeo, additional, Ochoa, Juan Eugenio, additional, Octavio, José Andrés, additional, Omboni, Stefano, additional, Palatini, Paolo, additional, Park, Jeong Bae, additional, Pellegrini, Dario, additional, Perl, Sabine, additional, Podoleanu, Cristian, additional, Pucci, Giacomo, additional, Redon, Josep, additional, Renna, Nicolas, additional, Rhee, Moo Yong, additional, Rodilla Sala, Enrique, additional, Sanchez, Ramiro, additional, Schmieder, Roland, additional, Soranna, Davide, additional, Stergiou, George, additional, Stojanovic, Milos, additional, Tsioufis, Konstantinos, additional, Valsecchi, Maria Grazia, additional, Veglio, Franco, additional, Waisman, Gabriel Dario, additional, Wang, Ji Guang, additional, Wijnmaalen, Paulina, additional, Zambon, Antonella, additional, Zanchetti, Alberto, additional, and Zhang, Yuqing, additional

Published
2018
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159. A17826 Cuff blood pressure is progressively more biased with increasing age

Author

Picone, Dean, primary, Schultz, Martin, additional, Otahal, Petr, additional, Al-Jumaily, Ahmed, additional, Bos, Willem, additional, Chen, Chen-Huan, additional, Cheng, Hao-Min, additional, Cremer, Antoine, additional, Fonseca-Diaz, Ricardo, additional, Gould, Brian, additional, Hughes, Alun, additional, Lacy, Peter, additional, Laugesen, Esben, additional, Muecke, Sandy, additional, Ohte, Nobuyuki, additional, Omboni, Stefano, additional, Ott, Christian, additional, Peng, Xiaoqing, additional, Pereira, Telmo, additional, Pucci, Giacomo, additional, Rossen, Niklas, additional, Schmieder, Roland, additional, Srikanth, Velandai, additional, Stewart, Ralph, additional, Stouffer, George, additional, Sueta, Daisuke, additional, Takazawa, Kenji, additional, Wang, Ji-Guang, additional, Weber, Thomas, additional, Westerhof, Berend, additional, Williams, Bryan, additional, Yamada, Hirotsugu, additional, Yamamoto, Eiichiro, additional, and Sharman, James, additional

Published
2018
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161. Isolated systolic hypertension in the young

Author

Palatini, Paolo, primary, Rosei, Enrico Agabiti, additional, Avolio, Alberto, additional, Bilo, Gregorz, additional, Casiglia, Edoardo, additional, Ghiadoni, Lorenzo, additional, Giannattasio, Cristina, additional, Grassi, Guido, additional, Jelakovich, Bojan, additional, Julius, Stevo, additional, Mancia, Giuseppe, additional, McEniery, Carmel M., additional, O’Rourke, Michael F., additional, Parati, Gianfranco, additional, Pauletto, Paolo, additional, Pucci, Giacomo, additional, Saladini, Francesca, additional, Strazzullo, Pasquale, additional, Tsioufis, Konstantinos, additional, Wilkinson, Ian B., additional, and Zanchetti, Alberto, additional

Published
2018
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163. Correction: Heritability of the dimensions, compliance and distensibility of the human internal jugular vein wall

Author

Tarnoki, Adam Domonkos, primary, Molnar, Andrea Agnes, additional, Tarnoki, David Laszlo, additional, Littvay, Levente, additional, Medda, Emanuela, additional, Fagnani, Corrado, additional, Arnofi, Antonio, additional, Farina, Filippo, additional, Baracchini, Claudio, additional, Meneghetti, Giorgio, additional, Pucci, Giacomo, additional, Schillaci, Giuseppe, additional, Stazi, Maria Antonietta, additional, and Nadasy, György L., additional

Published
2018
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165. Heritability of the dimensions, compliance and distensibility of the human internal jugular vein wall

Author

Tarnoki, Adam Domonkos, primary, Molnar, Andrea Agnes, additional, Tarnoki, David Laszlo, additional, Littvay, Levente, additional, Medda, Emanuela, additional, Fagnani, Corrado, additional, Arnolfi, Antonio, additional, Farina, Filippo, additional, Baracchini, Claudio, additional, Meneghetti, Giorgio, additional, Pucci, Giacomo, additional, Schillaci, Giuseppe, additional, Stazi, Maria Antonietta, additional, and Nadasy, György L., additional

Published
2018
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166. Femoral Artery Ultrasound Examination

Author

Lucatelli, Pierleone, Fagnani, Corrado, Tarnoki, Adam Domonkos, Tarnoki, David Laszlo, Stazi, Maria Antonietta, Salemi, Miriam, Cirelli, Carlo, Sacconi, Beatrice, D'Adamo, Alessandro, Fanelli, Fabrizio, Catalano, Carlo, Pucci, Giacomo, Schillaci, Giuseppe, Baracchini, Claudio, and Medda, Emanuela

Subjects
cardiovascular risk, Adult, Carotid Artery Diseases, Male, Carotid Artery, Common, Middle Aged, Prognosis, common carotid artery plaque, Carotid Intima-Media Thickness, Risk Assessment, common femoral artery plaque, Plaque, Atherosclerotic, Femoral Artery, Peripheral Arterial Disease, Young Adult, Italy, Predictive Value of Tests, Risk Factors, intima–media thickness, Prevalence, Humans, Female, Ultrasonography, Doppler, Color, Aged
Abstract

We compared intima-media thickness (IMT) and the prevalence of plaques in the common carotid artery (CCA) and common femoral artery (CFA) in apparently healthy participants. This multicenter study included 322 participants (59.9% female; age 20-78 years, mean 52.1 ± 15.3 years) who underwent Echo-color Doppler examination of the CCA and CFA bilaterally. Prevalence and composition of plaque were recorded. A significant ( P.01) difference between mean CCA-IMT and mean CFA-IMT was detected (0.70 vs 0.73 mm). Plaque prevalence was significantly higher in the CFA compared to the CCA (40.7% vs 30.4%). Atherosclerotic plaques were found in both CFA and CCA in 46% of the cases, solely in CFA in 38%, and in CCA alone in 17%. The observed difference in plaque prevalence was even greater when only fibrolipid isolated plaques were considered (CFA 39.4% vs CCA 22.1%). In a healthy general population, atherosclerotic plaques were present in the CFA but not in the CCA in over one-third of the cases. Further studies must confirm whether ultrasonography of the CFA might be introduced in the screening protocols for cardiovascular risk assessment.

Published
2016

167. Genetic influence on femoral plaque and its relationship with carotid plaque: an international twin study

Author

Lucatelli, Pierleone, primary, Fagnani, Corrado, additional, Tarnoki, Adam Domonkos, additional, Tarnoki, David Laszlo, additional, Sacconi, Beatrice, additional, Fejer, Bence, additional, Stazi, Maria Antonietta, additional, Salemi, Miriam, additional, Cirelli, Carlo, additional, d’Adamo, Alessandro, additional, Fanelli, Fabrizio, additional, Catalano, Carlo, additional, Maurovich-Horvat, Pal, additional, Jermendy, Adam L., additional, Jermendy, Gyorgy, additional, Merkely, Bela, additional, Molnar, Andrea A., additional, Pucci, Giacomo, additional, Schillaci, Giuseppe, additional, Farina, Filippo, additional, Meneghetti, Giorgio, additional, Baracchini, Claudio, additional, and Medda, Emanuela, additional

Published
2017
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173. Evaluation of Unattended Automated Office, Conventional Office and Ambulatory Blood Pressure Measurements and Their Correlation with Target Organ Damage in an Outpatient Population of Hypertensives: Study Design and Methodological Aspects.

Author

Mancusi, Costantino, Saladini, Francesca, Pucci, Giacomo, Bertacchini, Fabio, Bisogni, Valeria, Bruno, Rosa Maria, Rivasi, Giulia, Maloberti, Alessandro, Manzi, Maria Virginia, Rosticci, Martina, Monticone, Silvia, de Feo, Martina, Del Pinto, Rita, Geraci, Giulio, Canciello, Grazia, Pengo, Martino, and Parati, Gianfranco

Subjects
ACADEMIC medical centers, AMBULATORY blood pressure monitoring, ATHEROSCLEROSIS, BLOOD pressure measurement, CARDIOVASCULAR diseases risk factors, ECHOCARDIOGRAPHY, HYPERTENSION, RISK assessment, ANKLE brachial index, LEFT ventricular hypertrophy, DISEASE complications
Abstract

Accurate measurement of blood pressure (BP) has a pivotal role in the management of patients with arterial hypertension. Recently, introduction of unattended office BP measurement has been proposed as a method allowing more accurate management of hypertensive patients and prediction of hypertension-mediated target organ damage (HMOD). This approach to BP measurement has been in particular proposed to avoid the white coat effect (WCE), which can be easily assessed once both attended and unattended BP measurements are obtained. In spite of its interest, the role of WCE in predicting HMOD remains largely unexplored. To fill this gap the Young Investigator Group of the Italian Hypertension Society (SIIA) conceived the study "Evaluation of unattended automated office, conventional office and ambulatory blood pressure measurements and their correlation with target organ damage in an outpatient population of hypertensives". This is a no-profit multicenter observational study aiming to correlate attended and unattended BP measurements for quantification of WCE and to correlate WCE with markers of HMOD, such us left ventricular hypertrophy, left atrial dilatation, and peripheral atherosclerosis. The Ethical committee of the Federico II University hospital has approved the study. [ABSTRACT FROM AUTHOR]

Published
2019
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174. Prevalence of proximal ascending aorta and target organ damage in hypertensive patients: the multicentric ARGO-SIIA project (Aortic RemodellinG in hypertensiOn of the Italian Society of Hypertension).

Author

Milan, Alberto, Degli Esposti, Daniela, Salvetti, Massimo, Izzo, Raffaele, Moreo, Antonella, Pucci, Giacomo, Bruno, Giulia, Pareo, Ilenia, Parini, Angelo, Paini, Anna, Laurino, Flora I., Sormani, Paola, Sgariglia, Raffaella, Avenatti, Eleonora, De Luca, Nicola, and Working Group on Heart and Hypertension of the Italian Society of Hypertension

Published
2019
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175. Decreasing cardiovascular risk in HIV infection between 2005 and 2011

Author

De Socio GV, Parruti, G, Ricci, E, Maggi, P, Celesia, Bm, Penco, G, Martinelli, C, Franzetti, M, Di Biagio, A, Bonfanti, P, Pucci, Giacomo, Schillaci, Giuseppe, CISAI study group, De Socio, Gv, Parruti, G, Ricci, E, Maggi, P, Celesia, Bm, Penco, G, Martinelli, C, Franzetti, M, Di Biagio, A, Bonfanti, P, Pucci, G, Schillaci, G, (for the CISAI study, group. )., De Socio, G, and Celesia, B

Subjects
Adult, Male, medicine.medical_specialty, Immunology, Human immunodeficiency virus (HIV), HIV Infections, medicine.disease_cause, Risk profile, Risk Assessment, Internal medicine, Cardiovascular Disease, medicine, Immunology and Allergy, Humans, HIV Infection, Aged, Framingham Risk Score, business.industry, Middle Aged, medicine.disease, Infectious Diseases, Italy, Cardiovascular Diseases, Female, Metabolic syndrome, Lipodystrophy, Risk assessment, business, Human
Abstract

Cardiovascular risk profile was compared in 765 Italian HIV-infected outpatients enrolled in 2005 and in 765 individually age-matched and sex-matched patients enrolled in 2011. Median Framingham risk score was 8.6% in 2005 vs. 7.9% in 2011 (P = 0.04); metabolic syndrome was present in 40.3% vs. 33.4% (P = 0.006). Blood glucose, triglycerides, prevalence of smokers, and lipodystrophy were all significantly lower in 2011 (all P < 0.0001). Cardiovascular risk improved over a 6-year period in Italian HIV-infected patients.

Published
2014

176. Relationship between aortic and carotid stiffness with measures of adiposity in adolescents. The maciste study.

Author

Pucci, Giacomo, Martina, Mariella, Bianchini, Elisabetta, Gemignani, Vincenzo, D'Abbondanza, Marco, Curcio, Rosa, Battista, Francesca, Anastasio, Fabio, and Vaudo, Gaetano

Subjects
OBESITY, TONOMETRY
Abstract

Background: We evaluated the differential association between arterial stiffness, taken at different arterial segments (aortic and carotid), with global and local measures of adiposity, accounting for BP as a mediator of the relationship between fat accumulation and increased arterial stiffness. Methods: 322 healthy Italian adolescents from the MACISTE Study (Metabolic and Cardiovascular Investigation at School, TErni), were evaluated. BMI, waist, hip and neck circumferences (NC) were taken as measures of adiposity. Laboratory measures of adiposity were also collected. Arterial stiffness was measured through carotid-femoral pulse wave velocity (applanation tonometry, SphygmoCor), and at the carotid level (Cardiovascular suite, Quipu, Italy). Results: Mean age 17 ± 1.4 years, 56% boys, 40 (12%) with overweight. All central and peripheral measures of BP were higher in overweight vs normoweight (all p < 0.01) excluding peripheral and central DBPs, which were lower in overweight. The aortic-to-brachial pulse pressure amplification was reduced in overweight vs normoweight (1.51 ± 0.13 vs 1.58 ± 0,13, p < 0.01). Carotid and aortic stiffness were positively correlated with anthropometric and laboratory measures of adiposity. After adjustment for MAP, only NC remained associated with carotid (β = 0.24, p < 0.01) and aortic stiffness (β = 0.16, p = 0.02). After adjustment for central PP, only carotid (β = 0.15, p = 0.04), but not aortic stiffness (β = 0.12, p = 0.07) was associated with NC. Conclusions: Arterial stiffness, when assessed at different levels of central arteries, showed site-specific associations with measures of body fat adiposity. NC was the only measure of adiposity to show a BP-independent association with carotid stiffness. Carotid stiffness is a promising marker of pressure-independent vascular damage promoted by overweight status. [ABSTRACT FROM AUTHOR]

Published
2023
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182. Association Between Lifestyle and Systemic Arterial Hypertension in Young Adults: A National, Survey-Based, Cross-Sectional Study

Author

Bruno, Rosa Maria, primary, Pucci, Giacomo, additional, Rosticci, Martina, additional, Guarino, Laura, additional, Guglielmo, Chiara, additional, Agabiti Rosei, Claudia, additional, Monticone, Silvia, additional, Giavarini, Alessandra, additional, Lonati, Chiara, additional, Torlasco, Camilla, additional, Fedecostante, Massimiliano, additional, Manzi, Maria Virginia, additional, Pezzutto, Francesca, additional, Di Pilla, Marina, additional, Artom, Nathan, additional, Battistoni, Allegra, additional, Pignatelli, Giulia, additional, Sanga, Viola, additional, and Pengo, Martino Francesco, additional

Published
2016
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186. Cuff blood pressure is progressively more biased with increasing age: individual participant level analysis from the inspect consortium

Author

Picone, Dean, Schultz, Martin, Otahal, Petr, Al-Jumaily, Ahmed, Black, J. Andrew, Bos, Willem, Chen, Chen-Huan, Chen, Hao-Min, Cremer, Antoine, Dwyer, Nathan, Fonseca Diaz, Ricardo, Gould, Brian, Hughes, Alun, Kim, Hack-Lyoung, Lacy, Peter, Laugesen, Esben, Muecke, Sandy, Ohte, Nobuyuki, Omboni, Stefano, Ott, Christian, Peng, Xiaoqing, Pereira, Telmo, Pucci, Giacomo, Roberts-Thomson, Philip, Rossen, Niklas, Schmieder, Roland, Srikanth, Velandai, Stewart, Ralph, Stouffer, George, Sueta, Daisuke, Takazawa, Kenji, Wang, Ji-Guang, Weber, Thomas, Westerhof, Berend, Williams, Bryan, Yamada, Hirotsugu, Yamamoto, Eiichiro, and Sharman, James

Published
2018
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187. Genetic and environmental determinants of longitudinal stability of arterial stiffness and wave reflection: a twin study.

Author

Pucci, Giacomo, Tarnoki, Adam D., Medda, Emanuela, Tarnoki, David L., Littvay, Levente, Maurovich-Horvat, Pal, Jermendy, Adam L., Godor, Erika, Fejer, Bence, Hernyes, Anita, Lucatelli, Pierleone, Fanelli, Fabrizio, Farina, Filippo, Baracchini, Claudio, Meneghetti, Giorgio, Jermendy, Gyorgy, Merkely, Bela, Schillaci, Giuseppe, Fagnani, Corrado, and Stazi, Maria A.

Published
2018
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188. Genetic influence on femoral plaque and its relationship with carotid plaque: an international twin study.

Author

Lucatelli, Pierleone, Fagnani, Corrado, Tarnoki, Adam Domonkos, Tarnoki, David Laszlo, Sacconi, Beatrice, Fejer, Bence, Stazi, Maria Antonietta, Salemi, Miriam, Cirelli, Carlo, d’Adamo, Alessandro, Fanelli, Fabrizio, Catalano, Carlo, Maurovich-Horvat, Pal, Jermendy, Adam L., Jermendy, Gyorgy, Merkely, Bela, Molnar, Andrea A., Pucci, Giacomo, Schillaci, Giuseppe, and Farina, Filippo

Abstract

To disentangle genetic and environmental influences on the development of femoral plaques using a population of adult twins. To evaluate the potential role of shared genetic and environmental factors in the co-occurrence of femoral and carotid plaques. The sample included 566 twins belonging to 164 monozygotic (MZ) and 119 dizygotic (DZ) twin pairs, who underwent peripheral arterial assessment by B-mode ultrasound in different centers. The variance in femoral plaques onset was due to genetic factors and the remaining 50% was explained by common (15%) and unique (35%) environmental factors. Findings on sidedness and number of femoral plaques indicated that also these traits were mainly under genetic control. No effect of common environment was found on plaques composition, and variability of this trait was explained by genetics (64%) and unique environment (36%). Covariation between the liabilities to carotid and femoral plaques was mainly attributed to shared genes (77%), with the remaining 23% explained by individual-specific environmental factors shared by the two districts. Inter-individual differences in plaque onset as well as in their number, sidedness and composition are mainly genetic in origin. The results on the cooccurrence of carotid and femoral plaque underline the genetic role in atherogenesis. [ABSTRACT FROM AUTHOR]

Published
2018
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189. Exploring the Spectrum of Blood Pressure Associations with CKD: The International 24-Hour Aortic Blood Pressure Consortium (i24ABC)

Author

Bahous, Sola Aoun, Weber, Thomas, Haddad, Chadia S., Salameh, Pascale, De La Sierra, Alejandro, Argyris, Antonios A., Hametner, Bernhard, Mayer, Christopher C., Piskorz, Daniel L., Terentes-Printzios, Dimitrios, Rodilla, Enrique, Gkaliagkousi, Eugenia, Pierce, Gary L., Stergiou, George, Pucci, Giacomo, Blacher, Jacques, Kario, Kazuomi, Muiesan, Maria Lorenza, Agharazii, Mohsen, Jankowski, Piotr, Perl, Sabine, Wassertheurer, Siegfried, Zhang, Yi, Orter, Stefan, and Protogerou, Athanase

Published
2023
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194. Road Accident due to a Pancreatic Insulinoma

Author

Parisi, Amilcare, primary, Desiderio, Jacopo, additional, Cirocchi, Roberto, additional, Grassi, Veronica, additional, Trastulli, Stefano, additional, Barberini, Francesco, additional, Corsi, Alessia, additional, Cacurri, Alban, additional, Renzi, Claudio, additional, Anastasio, Fabio, additional, Battista, Francesca, additional, Pucci, Giacomo, additional, Noya, Giuseppe, additional, and Schillaci, Giuseppe, additional

Published
2015
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