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Background: Micro-RNAs could provide great insights about the neuropathological mechanisms associated with osteoarthritis (OA) pain processing. Using the validated Montreal Induction of Rat Arthritis Testing (MIRAT) model, this study aimed to characterize neuroepigenetic markers susceptible to correlate with innovative pain functional phenotype and targeted neuropeptide alterations. Methods: Functional biomechanical, somatosensory sensitization (peripheral--via tactile paw withdrawal threshold; central--via response to mechanical temporal summation), and diffuse noxious inhibitory control (via conditioned pain modulation) alterations were assessed sequentially in OA (n = 12) and Naïve (n = 12) rats. Joint structural, targeted spinal neuropeptides and differential expression of spinal cord micro-RNAs analyses were conducted at the sacrifice (day (D) 56). Results: The MI-RAT model caused important structural damages (reaching 35.77% of cartilage surface) compared to the Naïve group (P < 0.001). This was concomitantly associated with nociceptive sensitization: ipsilateral weight shift to the contralateral hind limb (asymmetry index) from -55.61% ± 8.50% (D7) to -26.29% ± 8.50% (D35) (P < 0.0001); mechanical pain hypersensitivity was present as soon as D7 and persisting until D56 (P < 0.008); central sensitization was evident at D21 (P = 0.038); pain endogenous inhibitory control was distinguished with higher conditioned pain modulation rate (P < 0.05) at D7, D21, and D35 as a reflect of filtrated pain perception. Somatosensory profile alterations of OA rats were translated in a persistent elevation of pro-nociceptive neuropeptides substance P and bradykinin, along with an increased expression of spinal miR-181b (P = 0.029) at D56. Conclusion: The MI-RAT OA model is associated, not only with structural lesions and static weight-bearing alterations, but also with a somatosensory profile that encompasses pain centralized sensitization, associated to active endogenous inhibitory/facilitatory controls, and corresponding neuropeptidomic and neuroepigenetic alterations. This preliminary neuroepigenetic research confirms the crucial role of pain endogenous inhibitory control in the development of OA chronic pain (not only hypersensitivity) and validates the MI-RAT model for its study. [ABSTRACT FROM AUTHOR]

The phenomenon of "the more targets, the higher probability" often occurs when people perform nonsymbolic probability judgment tasks. However, it remains unclear whether inhibitory control is needed to overcome this intuitive bias and whether the distance between the two probabilities moderates this process. We designed a probability judgment task with large and small distances and conducted two experiments. In Experiment 1 (n = 31), participants judged which box was more likely to get the target ball in the congruent task (more targets, higher probability) or the incongruent task (fewer targets, higher probability). Participants demonstrated an intuitive bias that was affected by numerical distance. In Experiment 2 (n = 33), we adopted the negative priming paradigm and found that participants required inhibitory control to overcome intuitive bias only in small-distance tasks. These results show that inhibitory control plays an essential role in overcoming intuitive bias in nonsymbolic probability judgment and that numerical distance has a moderating effect. [ABSTRACT FROM AUTHOR]

In the current study, it was aimed to evaluate neurotrophic factor levels and their relationship with executive functions in high-risk children and adolescents (high-risk group) whose parents were diagnosed with bipolar disorder (BD) but not affected by any psychiatric disease,and in order to determine possible vulnerability factors related to the disease. The study sample consisted of 32 high-risk group and 34 healthy controls. The Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version-Turkish Adaptation (KSADS-PL-T), Stroop Test, Serial Digit Learning Test (SDLT) and Cancellation Test to evaluate executive functions were administered to all participants by the clinician.Serum levels of neurotrophic factors were measured using commercial enzyme linked immunosorbent assay kits. Serum BDNF, NT-3, NT-4 levels and SDLT scores were significantly lower in the high-risk group for BD compared to the healthy control group. A moderate negative correlation was found between BDNF levels and the Cancellation Test scores in the high-risk group. In addition to these results, the odds ratios of age, NT-4, SDLT scores for being in the risky group in terms of BD diagnosis were 1.26, 0.99 and 0.86 respectively. This was a cross-sectional study. Causality between study results is therefore difficult to establish. The relatively small sample size of the study is another limitation. The results of the present study suggest that BDNF, NT-3, NT-4 may play a role in the physiopathology of BD and may be associated with impaired executive function areas such as attention and response inhibition in the high-risk group. • Neurotrophic factors may play a role in the pathophysiology of bipolar disorder. • Neurotrophic factors may be associated with impaired executive functions. • Examination of the offspring of bipolar parents provides an opportunity to investigate early changes. [ABSTRACT FROM AUTHOR]

The receptor–receptor interaction (RRI) of G protein-coupled receptors (GPCRs) leads to new functional entities that are conceptually distinct from the simple addition of signals mediated by the activation of the receptors that form the heteromers. Focusing on astrocytes, there is evidence for the existence of inhibitory and facilitatory RRIs, including the heteromers formed by the adenosine A2A and the dopamine D2 receptors, by A2A and the oxytocin receptor (OTR), and the D2-OTR heteromers. The possible involvement of these receptors in mosaicism has never been investigated in striatal astrocytes. By biophysical and functional approaches, we focused our attention on the existence of an A2A-D2-OTR high-order receptor complex and its role in modulating cytosolic calcium levels and endogenous glutamate release, when striatal astrocyte processes were stimulated with 4-aminopyridine. Functional data indicate a permissive role of OTR on dopamine signaling in the regulation of the glutamatergic transmission, and an inhibitory control mediated by A2A on both the D2-mediated signaling and on the OTR-facilitating effect on D2. Imaging biochemical and bioinformatic evidence confirmed the existence of the A2A-D2-OTR complex and its ternary structure in the membrane. In conclusion, the D2 receptor appears to be a hotspot in the control of the glutamate release from the astrocytic processes and may contribute to the regulation and integration of different neurotransmitter-mediated signaling in the striatum by the A2A-D2-OTR heterotrimers. Considering the possible selectivity of allosteric interventions on GPCRs organized as receptor mosaics, A2A-D2-OTR heterotrimers may offer selective pharmacological targets in neuropsychiatric disorders and neurodegenerative diseases. [ABSTRACT FROM AUTHOR]

The present study investigates how heritage speakers conduct good-enough processing at the interface of home-language proficiency, cognitive skills (inhibitory control; working memory), and task types (acceptability judgement; self-paced reading). For this purpose, we employ two word-order patterns (verb-final vs. verb-initial) of two clausal constructions in Korean--suffixal passive and morphological causative--which contrast pertaining to the mapping between thematic roles and case-marking and the interpretive procedures driven by verbal morphology. We find that, while Korean heritage speakers demonstrate the same kind of acceptability-rating behaviour as monolingual Korean speakers do, their reading-time patterns are notably modulated by construction-specific properties, cognitive skills, and proficiency. This suggests a heritage speaker's ability and willingness to conduct both parsing routes, induced by linguistic cues in a non-dominant language, which are proportional to the computational complexity involving these cues. Implications of this study are expected to advance our understanding of a learner's mind for underrepresented languages and populations in the field. [ABSTRACT FROM AUTHOR]

Background: The evolution of the primate brain has been characterized by the reorganization of key structures and circuits underlying derived specializations in sensory systems, as well as social behavior and cognition. Among these, expansion and elaboration of the prefrontal cortex has been accompanied by alterations to the connectivity and organization of subcortical structures, including the striatum and amygdala, underlying advanced aspects of executive function, inhibitory behavioral control, and socioemotional cognition seen in our lineages. At the cellular level, the primate brain has further seen an increase in the diversity and number of inhibitory GABAergic interneurons. A prevailing hypothesis holds that disruptions in the balance of excitatory to inhibitory activity in the brain underlies the pathophysiology of many neurodevelopmental and psychiatric disorders. Summary: This review highlights the evolution of inhibitory brain systems and circuits and suggests that recent evolutionary modifications to GABAergic circuitry may provide the substrate for vulnerability to aberrant neurodevelopment. We further discuss how modifications to primate and human social organization and life history may shape brain development in ways that contribute to neurodivergence and the origins of neurodevelopmental disorders. Key Messages: Many brain systems have seen functional reorganization in the mammalian, primate, and human brain. Alterations to inhibitory circuitry in frontostriatal and frontoamygdalar systems support changes in social behavior and cognition. Increased complexity of inhibitory systems may underlie vulnerabilities to neurodevelopmental and psychiatric disorders, including autism and schizophrenia. Changes observed in Williams syndrome may further elucidate the mechanisms by which alterations in inhibitory systems lead to changes in behavior and cognition. Developmental processes, including altered neuroimmune function and age-related vulnerability of inhibitory cells and synapses, may lead to worsening symptomatology in neurodevelopmental and psychiatric disorders. [ABSTRACT FROM AUTHOR]

Under total sleep deprivation, both inhibitory and motor control are impaired. However, how circadian rhythm sleep loss caused by irregular sleep pattern affects motor inhibition and execution in continuous actions remains unknown. This study utilized a pointing task to investigate the question over 30 days. During regular trials, participants were instructed to tap on a specified location, while in countermanding trials, they were required to countermand their current action. Additionally, there was a control group performed the same task following a normal 24-h rhythm. The results indicated that the decrease in accuracy and the increase in movement time in countermanding trials were more prominent in the shift work group. In contrast, there was no significant difference in reaction time between the two groups. Notably, the shift work group outperformed the control group in terms of movement time in regular trials and radial displacement in countermanding trials. Overall, these results show that circadian rhythm sleep loss predominantly affects inhibitory control, rather than motor control, underscoring the nuanced impacts of sleep disruption on differential aspects of cognitive and motor functions. [ABSTRACT FROM AUTHOR]

Recent research suggests that socio-ecological factors such as dietary specialization and social complexity may be drivers of advanced cognitive skills among primates. Therefore, we assessed the ability of 12 black-handed spider monkeys (Ateles geoffroyi), a highly frugivorous platyrrhine primate with strong fission-fusion dynamics, to succeed in a serial visual reversal learning task. Using a two-alternative choice paradigm we first trained the animals to reliably choose a rewarded visual stimulus over a non-rewarded one. Upon reaching a pre-set learning criterion we then switched the reward values of the two stimuli and assessed if and how quickly the animals learned to reverse their choices, again to a pre-set learning criterion. This stimulus reversal procedure was then continued for a total of 80 sessions of 10 trials each. We found that the spider monkeys quickly learned to reliably discriminate between two simultaneously presented visual stimuli, that they succeeded in a visual reversal learning task, and that they displayed an increase in learning speed across consecutive reversals, suggesting that they are capable of serial reversal learning-set formation with visual cues. The fastest-learning individual completed five reversals within the 80 sessions. The spider monkeys outperformed most other primate and nonprimate mammal species tested so far on this type of cognitive task, including chimpanzees, with regard to their learning speed in both the initial learning task and in the first reversal task, suggesting a high degree of behavioral flexibility and inhibitory control. Our findings support the notion that socio-ecological factors such as dietary specialization and social complexity foster advanced cognitive skills in primates. [ABSTRACT FROM AUTHOR]

The role of serotonin in human behaviour is informed by approaches which allow in vivo modification of synaptic serotonin. However, characterising the effects of increased serotonin signalling in human models of behaviour is challenging given the limitations of available experimental probes, notably selective serotonin reuptake inhibitors. Here we use a now-accessible approach to directly increase synaptic serotonin in humans (a selective serotonin releasing agent) and examine its influence on domains of behaviour historically considered core functions of serotonin. Computational techniques, including reinforcement learning and drift diffusion modelling, explain participant behaviour at baseline and after week-long intervention. Reinforcement learning models reveal that increasing synaptic serotonin reduces sensitivity for outcomes in aversive contexts. Furthermore, increasing synaptic serotonin enhances behavioural inhibition, and shifts bias towards impulse control during exposure to aversive emotional probes. These effects are seen in the context of overall improvements in memory for neutral verbal information. Our findings highlight the direct effects of increasing synaptic serotonin on human behaviour, underlining its role in guiding decision-making within aversive and more neutral contexts, and offering implications for longstanding theories of central serotonin function. Serotonin is involved in aversive processing, but how serotonin shapes behavior remains unclear. Here, the authors show that directly enhancing synaptic serotonin in humans reduces outcome sensitivity and increases behavioral inhibition in aversive contexts. [ABSTRACT FROM AUTHOR]

The aim of this study was to determine the role of duration of preschool attendance and the quality of teacher-child interactions in the executive functions development of preschoolers. The study involved 947 children (51% girls) age 4-7 years (M = 70.3 months; SD = 4.3). The number of children attending kindergarten for less than 1 year was 144; 268 children (28.3%) had attended for 1 to 2 years; and 535 children (56.5%) had attended for more than 2 years. The results showed that the children who attended a group with a high quality of teacher-child interaction for one or more years had better results on verbal work memory, and cognitive and physical inhibitory control than those who attended the same group over a shorter period. [ABSTRACT FROM AUTHOR]

Recent advances in AI and intelligent vehicle technology hold the promise of revolutionizing mobility and transportation through advanced driver assistance systems (ADAS). Certain cognitive factors, such as impulsivity and inhibitory control have been shown to relate to risky driving behavior and on-road risk-taking. However, existing systems fail to leverage such factors in assistive driving technologies adequately. Varying the levels of these cognitive factors could influence the effectiveness and acceptance of ADAS interfaces. We demonstrate an approach for personalizing driver interaction via driver safety interfaces that are are triggered based on the inference of the driver's latent cognitive states from their driving behavior. To accomplish this, we adopt a data-driven approach and train a recurrent neural network to infer impulsivity and inhibitory control from recent driving behavior. The network is trained on a population of human drivers to infer impulsivity and inhibitory control from recent driving behavior. Using data collected from a high-fidelity vehicle motion simulator experiment, we demonstrate the ability to deduce these factors from driver behavior. We then use these inferred factors to determine instantly whether or not to engage a driver safety interface. This approach was evaluated using leave-one-out cross validation using actual human data. Our evaluations reveal that our personalized driver safety interface that captures the cognitive profile of the driver is more effective in influencing driver behavior in yellow light zones by reducing their inclination to run through them. [ABSTRACT FROM AUTHOR]

Background and Objectives: With the expansion of the use of internet technology, teenagers, as a group of society that use cyber space more, are exposed to its abuse. The aim of the present study was to determine the structural equation model of cyberbullying based on the brain/behavioral system with the mediating role of cognitive emotion regulation in students. Materials and Methods: In the current descriptive study, the statistical population was all students of secondary school (second period) in Gotvand City in 2022-2023. Three-hundred and eighty people were selected by multi-stage cluster random sampling method and responded to the Behavioral Inhibition/Activation, Cyberbullying-Victim Experience, and Emotional Eegulation Scales. Data analysis was performed by structural equations modeling method. Results: Direct effects of behavioral inhibition system on cyberbullying (β=-0.460, p=0.001), behavioral activation on cyberbullying (β=0.299, p=0.001), and cognitive regulation of excitement on cyberbullying (β=-0.376, p=0.001), and also inhibition of behavior on cognitive regulation of emotion (β=0.235, p=0.001), activation of behavior on cognitive regulation of emotion (β=-0.239, p=0.001) were significant. Moreover, the indirect effects of inhibiting behavior on cyberbullying through cognitive regulation of emotion (β=- 0.122, p=0.001) and activating behavior on cyberbullying through cognitive regulation of emotion (β=-0.200, p=0.001) were significant. Conclusion: The results of the present study showed that the behavior inhibition/behavior activation system is effective directly and through the cognitive regulation of emotion on cyberbullying, and the cognitive regulation of emotion also has a direct effect on cyberbullying. The results of the present research will help education experts and psychotherapists in identifying variables related to behavioral and emotional control conditions in order to increase the mental health and quality of life of adolescents with the optimal use of cyber technology. [ABSTRACT FROM AUTHOR]

Background and Objectives: In addition to physical fitness, the achievement of sports success for athletes depends on other items such as favorable mental and emotional conditions; hence the purpose of this research was to test the causal model of sports success based on brain-behavioral systems with the mediation of dimensions of the nature and character of the athletes of Ahvaz City. Materials and Methods: The present study was a descriptive study using structural equation modeling. The statistical population of this research included all the athletes of Ahvaz City in 2023, out of which 254 people were purposefully selected as a sample group from among the athletes present in the sports clubs of Ahvaz City. The measurement tools of the present study were the Sports Success Scale (Mousavi and Vaezmousavi, 2015), the Brain/Behavioral Systems Questionnaire (Carver and White, 1994), and the Nature and Character Questionnaire (Cloninger et al., 1994). The data was analyzed using structural equation analysis method. Results: The results showed that the final model fits the data. The relationship between the behavioral activation system and personality dimensions with sports success was positive (p<0.05) and the relationship between the behavioral inhibition system and sports success was negative and significant (p<0.05). Also, the indirect relationship between the behavioral inhibition system and sports success with the mediation of temperament dimensions was not significant (p>0.05). On the other hand, the indirect relationship between behavioral activation system and sports success with the mediation of personality dimension was significant (p<0.05). Conclusion: Behavioral activator and inhibitory system and dimensions of character and personality can be effective in sports growth and success of athletes, and sports psychologists can pay attention to this. [ABSTRACT FROM AUTHOR]

Impulsivity-characterized executive function impairments have been hypothesized to represent mechanisms underlying the symptomology associated with gambling disorder (GD). Despite this, a clear profile of executive function within GD has yet to be established. Furthermore, it remains unclear whether executive function deficits represent a vulnerability marker for the disorder. This study assessed executive function performance within a GD sample compared to a sample of familial relatives and community controls. Using a family study methodology, a broad assessment of executive function was administered to analyze performance differences and their potential characterization by impulsivity between a sample of individuals meeting criteria for GD, their first-degree familial relatives, and a community control sample. Performance differences emerged regarding the capacity to delay gratification and inhibit automatic task-irrelevant responses between the GD and control samples. Results support the presence of impulsive choice and impulsive cognitive bias as components of the GD executive functioning profile. Similar difficulties inhibiting automatic attentional shifting were observed within the first-degree relative sample. Executive functioning within GD appears to be characterized by an impulsive pattern of behaviours/decisions but impacts processes differently. Evidence suggests that individuals diagnosed with GD demonstrate a statistically different capacity to delay gratification (e.g. a propensity towards smaller, more immediate rewards as opposed to larger delayed rewards) and inhibit cognitive biases (e.g. difficulty shifting attention away from task-irrelevant stimuli). This latter difference may represent a vulnerability marker of GD as preliminary evidence was provided for similar difficulties in a first-degree relative sample. Further research must replicate these findings and assess the impact of task modality, symptom severity, and comorbidity on the observation of executive functioning impairment. [ABSTRACT FROM AUTHOR]

Background: The frontal cortex, relevant to global cognition and motor function, is recruited to compensate for mobility dysfunction in older adults. However, the in vivo neurophysiological (e.g., neurometabolites) underpinnings of the frontal cortex compensation for mobility dysfunction remain poorly understood. The purpose of this study was to investigate the relationships among frontal cortex neurophysiology, mobility, and cognition in healthy older adults. Methods: Magnetic Resonance Spectroscopy (MRS) quantified N-acetylasparate (tNAA) and total choline (tCho) concentrations and ratios in the frontal cortex in 21 older adults. Four inertial sensors recorded the Timed Up & Go (TUG) test. Cognition was assessed using the Flanker Inhibitory Control and Attention Test which requires conflict resolution because of response interference from flanking distractors during incongruent trials. Congruent trials require no conflict resolution. Results: tNAA concentration significantly related to the standing (p = 0.04) and sitting (p = 0.03) lean angles. tCho concentration (p = 0.04) and tCho ratio (p = 0.02) significantly related to TUG duration. tCho concentration significantly related to incongruent response time (p = 0.01). tCho ratio significantly related to both congruent (p = 0.009) and incongruent (p < 0.001) response times. Congruent (p = 0.02) and incongruent (p = 0.02) Flanker response times significantly related to TUG duration. Conclusions: Altered levels of frontal cortex neurometabolites are associated with both mobility and cognitive abilities in healthy older adults. Identifying neurometabolites associated with frontal cortex compensation of mobility dysfunction could improve targeted therapies aimed at improving mobility in older adults. [ABSTRACT FROM AUTHOR]

Increased aggression due to gaming addiction is a widespread and highly publicized problem. The underlying processes by which verbal aggression, a more harmful and persistent subcategory of aggression, is affected by gaming addiction may differ from other types of aggression. In this study, data came from 252 randomly recruited current university students (50.79% male, mean age 19.60 years, SD: 1.44 years, range 17 to 29 years). Participants reported gaming addiction and different types of aggression through questionnaires. In addition, two important explanatory processes, inhibitory control, and risk preference, were measured through behavioral experiments. A Bayesian hierarchical drift-diffusion model was employed to interpret the data from the risk preference task. In contrast to previous work, the study found that inhibitory control did not significantly correlate with either gaming addiction or any form of aggression However, the drift rate, a measure of decision-making inclination under risk, partially mediates the relationship between gaming addiction and verbal aggression (but not other forms of aggression). The findings illuminate risk preference under adverse conditions as a key predictor of verbal aggression, offering avenues for early intervention and suggesting game design modifications to mitigate verbal aggression by adjusting reward mechanisms. [ABSTRACT FROM AUTHOR]

Recent theory suggests that both the orienting response and arousal inhibition play roles in the effect of the concealed information test (CIT). However, the neural signatures associated with these two processes remain unclear. To address this issue, participants were motivated to either conceal or reveal crime-related stimulus during CIT while EEG was recorded. By using a temporal principal component analysis, we found that crime-related stimuli produced a larger early P3 than crime-irrelevant stimuli in both the conceal condition and reveal condition. This result suggests that this early P3 reflects an orienting response. In addition, we found that crime-related stimuli elicited a larger frontal negative slow wave than crime-irrelevant stimuli in the conceal condition but not the reveal condition, which suggests that the frontal negative slow wave reflects the arousal inhibition process. These results provide crucial evidence for understanding the neural basis underlying CIT. [ABSTRACT FROM AUTHOR]

This document provides a summary of articles and presentations from the International Journal of Psychology. The topics covered include neuropsychological assessment in the early stages of Alzheimer's disease, the classification of mild cognitive impairment, dyadic discrepancies in symptom reporting, relational memory binding tests for Alzheimer's disease, neuropsychological functioning and substance use in adolescent patients with first episode psychosis, neurocognitive interventions for children and adolescents with psychosis, affective speech prosody and its impact on instruction, the impact of long-term meditation practice on emotional responses, the association between the APOE4 gene variant and cognitive decline in older adults, a digital diagnostic tool for mild cognitive impairment, and the effects of dance training on cerebellar connectivity and cognitive performance in schizophrenia patients. These studies provide valuable insights into various aspects of cognitive function and mental health, highlighting the importance of early detection, intervention, and understanding of these conditions. [Extracted from the article]

Temporomandibular disorders (TMDs) are the most common cause of non-dental chronic pain in the orofacial region and can chronically increase the activity of the allostatic systems. The allostatic overload related to these conditions causes an autonomic dysregulation, reflected by a reduction in heart rate variability (HRV). Nevertheless, chronic pain in these patients could cause more severe health consequences, such as those related to cognitive functioning. Deficits in executive control have been associated with allostatic overload and could negatively affect pain management strategies. This study aimed to investigate the effects of chronic pain on HRV and both motor and cognitive inhibition (assessed with the Go/No-Go and Stroop tasks, respectively) in a sample of 14 patients with TMD and 15 healthy controls. Consistent with our hypothesis and the previous literature, the group with TMD had a lower resting HRV, but no differences were found between the groups in inhibition. Furthermore, the results showed that the effects of HRV on cognitive inhibition can be mediated by pain intensity. Finally, a correlation between age and HRV emerged in patients with TMD but not in healthy controls. [ABSTRACT FROM AUTHOR]

Aim: The primary aim of this study was to conduct an open pilot clinical trial of a brief mindfulness‐based intervention for persistent postconcussion symptoms that occur after mild traumatic brain injury in military service members. For many service members, operational tempo and other time constraints may prevent them from completing a standard mindfulness‐based stress reduction course. Thus, this study sought to examine the effectiveness of a five‐session intervention called mindfulness‐based stress, pain, emotion, and attention regulation (MSPEAR). Methods: Participants were active duty service members with a history of mild traumatic brain injury (TBI) and persisting postconcussion symptoms, all of whom were recruited from an outpatient TBI rehabilitation program at a military treatment facility. Of the 38 service members that were initially enrolled, 25 completed the 5‐session MSPEAR intervention, and 20 returned for a 5‐week follow‐up evaluation. Questionnaires assessing perceived stress, positive affect, pain interference and catastrophizing, sleep disturbances, perceived behavioral and attention regulation, self‐efficacy and satisfaction with life were administered at preintervention, postintervention, and at 5‐week follow‐up intervals. Neuropsychological testing at preintervention and 5‐week follow‐up included performance validity measures, attention, working memory, and executive function measures. T‐tests were run to compare for questionnaire measures at preintervention (Time 1) to postintervention (Time 2). Repeated analysis of variances were conducted to compare questionnaire and neuropsychological measures at Time 1, Time 2, and at Time 3 which is the 5‐week follow‐up. Results: Improvements in perceived stress, positive affect, behavioral regulation, metacognition, sleep disturbance, self‐efficacy, and satisfaction with life were found immediately after the MSPEAR intervention and were maintained at the 5‐week follow‐up. Magnification and helplessness aspects of pain catastrophizing improved when comparing preintervention to the 5‐week follow‐up. Pain interference was not significantly different across study assessment times. Neuropsychological testing revealed improvements in sustained attention, working memory, cognitive flexibility, and inhibitory control when comparing preintervention to the 5‐week follow‐up assessment. Conclusions: The MSPEAR intervention appears to show promise as a brief and effective therapy for specific postconcussion symptoms after mild traumatic brain injury in military service members. Each of the components of MSPEAR including stress, pain catastrophizing, emotion and attention regulation showed improvements in this study, and bears further investigation in a larger scale, preferably randomized controlled trial in those active duty military service members who experience persisting symptoms after a mild traumatic brain injury. [ABSTRACT FROM AUTHOR]

"Pavlovian" or "motivational" biases describe the phenomenon that the valence of prospective outcomes modulates action invigoration: Reward prospect invigorates action, whereas punishment prospect suppresses it. The adaptive role of these biases in decision-making is still unclear. One idea is that they constitute a fast-and-frugal decision strategy in situations characterized by high arousal, e.g., in presence of a predator, which demand a quick response. In this pre-registered study (N = 35), we tested whether such a situation—induced via subliminally presented angry versus neutral faces—leads to increased reliance on Pavlovian biases. We measured trial-by-trial arousal by tracking pupil diameter while participants performed an orthogonalized Motivational Go/NoGo Task. Pavlovian biases were present in responses, reaction times, and even gaze, with lower gaze dispersion under aversive cues reflecting "freezing of gaze." The subliminally presented faces did not affect responses, reaction times, or pupil diameter, suggesting that the arousal manipulation was ineffective. However, pupil dilations reflected facets of bias suppression, specifically the physical (but not cognitive) effort needed to overcome aversive inhibition: Particularly strong and sustained dilations occurred when participants managed to perform Go responses to aversive cues. Conversely, no such dilations occurred when they managed to inhibit responses to Win cues. These results suggest that pupil diameter does not reflect response conflict per se nor the inhibition of prepotent responses, but specifically effortful action invigoration as needed to overcome aversive inhibition. We discuss our results in the context of the "value of work" theory of striatal dopamine. [ABSTRACT FROM AUTHOR]

The Reinforcement Sensitivity Theory, first proposed by Gray and later revised, describes three motivational systems: Behavioral Inhibition System (BIS), Behavioral Activation System (BAS), and Fight-Flight-Freeze System (FFFS). Studies have shown that high BIS and FFFS activation are positively related to anxiety symptoms, yet the relationship between BAS and anxiety remains unclear. Research data have also suggested that anxiety symptoms occur with the loss of perceived control. Thus, although studies on the direct effect of locus of control (LOC) on trait anxiety have accumulated for many years, the issue of how LOC may mediate the relationship between BIS/BAS/FFFS sensitivity and anxiety has not been addressed. This study aimed to explore the mediating role of LOC orientation on trait anxiety among young adults in association with these three motivational systems. Cross-sectional data were obtained from 422 volunteers. The BIS/BAS Scale, Trait Anxiety Inventory, and Rotter's Internal-External LOC Scale were applied. A series of mediation analyses were performed to estimate total, indirect, and direct effects. The results showed that BIS and FFFS positively predicted trait anxiety. In addition, LOC positively predicted trait anxiety and BIS. The results of the mediation analyses indicated that LOC functioned as a partial mediator between BIS and trait anxiety. This finding revealed that a high BIS level, one of the motivational systems, was associated with external LOC, which in turn contributed to reporting high trait anxiety in young adults. Hence, BIS and external LOC orientation could be suggested as risk factors for trait anxiety. As the external LOC orientation of individuals with high punishment sensitivity increased, their trait anxiety levels also increased. Therefore, it was suggested that it might be useful to be aware that LOC orientations of individuals with BIS sensitivity may pose a risk for trait anxiety. [ABSTRACT FROM AUTHOR]

Previous work has indicated that individual differences in cognitive performance can be predicted by characteristics of resting state oscillations, such as individual peak alpha frequency (IAF). Although IAF has previously been correlated with cognitive functions, such as memory, attention, or mental speed, its link to cognitive conflict processing remains unexplored. The current work investigated the relationship between IAF and inhibitory cognitive control in two well‐established conflict tasks, Stroop and Navon task, while also controlling for alpha power, theta power, and the 1/f offset of aperiodic broadband activity. In Bayesian analyses on a large sample of 127 healthy participants, we found substantial evidence against the assumption that IAF predicts individual abilities to spontaneously exert cognitive control. Similarly, our findings yielded substantial evidence against links between cognitive control and resting state power in the alpha and theta bands or between cognitive control and aperiodic 1/f offset. In sum, our results challenge frameworks suggesting that an individual's ability to spontaneously engage attentional control networks may be mirrored in resting state EEG characteristics. In the first work investigating the relationship between individual peak alpha frequency (IAF) and two classical conflict tasks (Stroop and Navon task), we demonstrate that individual differences in cognitive control are not related to IAF nor to other oscillatory or aperiodic aspects of the resting state EEG signal. We complement and challenge previous findings suggesting IAF as a neurophysiological indicator of general human performance functions and cognitive control specifically. [ABSTRACT FROM AUTHOR]

The revised reinforcement sensitivity theory (RST) proposes that neurobiological systems control behavior: the fight‐flight‐freeze (FFFS) for avoidance of threat; behavioral approach/activation (BAS) for approach to rewards; and behavioral inhibition (BIS) for conflict resolution when avoidance and approach are possible. Neuroimaging studies have confirmed some theoretical associations between brain structures and the BAS and BIS; however, little representative population data are available for the FFFS. We investigated the neural correlates of the revised RST in a sample of 404 middle‐aged adults (Mage = 47.18 (SD = 1.38); 54.5% female). Participants underwent structural magnetic resonance imaging and completed health questionnaires and the BIS/BAS/FFFS scales. We used multiple regression analyses to investigate the association between scale scores and volumes of a priori theoretically linked regions of interest while controlling for sex, age, intracranial volume, and cardio‐metabolic variables; and conducted exploratory analyses on cortical thickness. The BIS was negatively associated with hippocampus laterality. At standard significance levels, the fear component of the FFFS was positively associated with anterior cingulate cortex; the BAS was positively associated with bilateral caudate; and the BIS was positively associated with posterior cingulate cortex volume. Furthermore, these neurobiological systems showed distinct patterns of association with cortical thickness though future work is needed. Our results showed that the neurobiological systems of the revised RST characterized in rodents can also be identified in the human brain. The revised Reinforcement Sensitivity Theory provides a comprehensive integration of neurobiology and behavior to help understand individual differences in physical and mental health, yet efforts to study the link between brain and behavior have been hampered due to inadequate measures. Using a revised and validated questionnaire, we showed that brain structure volume and cortical thickness differences are associated with each of the proposed neurobiological systems of the revised Reinforcement Sensitivity Theory. [ABSTRACT FROM AUTHOR]

We investigated the association between persistence and change in behavioral difficulties during early to middle childhood and several cognitive outcomes. We observed 3904 8-year-olds enrolled in the longitudinal study Growing Up in New Zealand (50% male/female; 23% Māori, 9% Pacific Peoples, 13% Asian, 2% Middle Eastern/Latin American/African, 9% Other, 43% European). The NIH Toolbox Cognition Battery was used to assess cognitive functioning at 8 years and the Strengths and Difficulties Questionnaire for behavioral difficulties at 4.5 and 8 years. Multivariate logistic regression analyses were conducted, controlling for well-known sociodemographic confounders. Children with persistent or later onset of behavioral difficulties were at higher risk for poorer vocabulary, reading, inhibitory control/attention, episodic memory, working memory and processing speed at age 8 compared to children with no or improved difficulties. Our study supports the importance of addressing both cognitive and behavioral aspects when planning educational programmes and interventions in early and middle childhood. [ABSTRACT FROM AUTHOR]

Behavioural lateralization is widespread across animal taxa. Consistent with the idea that lateralization indicates advantageous specialization of the brain hemispheres, individuals with more lateralized behaviour are often found to have better cognition. Among-individual differences in behavioural lateralization nevertheless exist, sometimes associated with differences in other phenotypic traits. Knowing which phenotypes are associated with behavioural lateralization gives cues as to why differences in lateralization exist within populations, but past research has often focused on one or a few phenotypes, and found different, sometimes opposed, correlations with lateralization. Here, we assayed behavioural lateralization of common waxbills, Estrilda astrild , in a feeding task, to test for associations with phenotypic differences, using a broad set of traits that might influence or be influenced by lateralization: a cognitive trait (inhibitory control), size, personality, social dominance, cues of stress and sex. Most individuals consistently fed with the right side towards the food, resulting in a population level right-side lateralization. However, evaluating photographs from waxbills feeding in the wild worldwide, we found no evidence of a preferred feeding side, contrasting with results in our population. There were also differences between individuals in our population in the direction and strength of lateralization. Females were, on average, more right-side lateralized than males, and there were larger among-individual differences in lateralization among males. None of the phenotypes studied predicted differences in the strength of lateralization. However, individual differences in the direction of lateralization were related to inhibitory control, an aspect of cognition, more strongly so in males than in females. These are among the few results indicating that the direction of behavioural lateralization, rather than its strength, is associated with cognitive differences among individuals. It is also the first time that a sex-dependent association between behavioural lateralization and cognitive performance has been found, suggesting that sex-specific functions are implicated in maintaining differences in behavioural lateralization. • It is still not clear why individuals differ in behavioural lateralization. • We studied the direction and strength of common waxbill behavioural lateralization. • Most individuals fed preferentially with their right side from a feeder. • We found sex differences in lateralization and, in males, associations with cognition. • Sex-specific functions may thus help maintain differences in lateralization. [ABSTRACT FROM AUTHOR]

Reactive inhibitory control plays an important role in phenotype of different diseases/different phases of a disease. One candidate electrophysiological marker of inhibitory control is frontal alpha asymmetry (FAA). FAA reflects the relative difference in contralateral frontal brain activity. However, the relationship between FAA and potential behavioral/brain activity indices of reactive inhibitory control is not yet clear. We assessed the relationship between resting-state FAA and indicators of reactive inhibitory control. Additionally, we investigated the effect of modulation of FAA via transcranial direct current stimulation (tDCS). We implemented a randomized sham-controlled design with 65 healthy humans (Mage = 23.93, SDage = 6.08; 46 female). Before and after 2-mA anodal tDCS of the right frontal site (with the cathode at the contralateral site) for 20 min, we collected EEG data and reactive inhibitory performance in neutral and food-reward conditions, using the stop signal task (SST). There was no support for the effect of tDCS on FAA or any indices of reactive inhibitory control. Our correlation analysis revealed an association between inhibitory brain activity in the food-reward condition and (pre-tDCS) asymmetry. Higher right relative to left frontal brain activity was correlated with reduced early-onset inhibitory activity and, in contrast, linked with higher late-onset inhibitory control in the food-reward condition. Similarly, event-related potential analyses showed reduced early-onset and enhanced late-onset inhibitory brain activity over time, particularly in the food-reward condition. These results suggest that there can be a dissociation regarding the lateralization of frontal brain activity and early- and late-onset inhibitory brain activity. NEW & NOTEWORTHY: This research reveals dissociation between baseline frontal alpha asymmetry and the timing of reactive inhibitory brain activities in food-reward contexts. Whereas inhibitory control performance decreases over time in a stop signal task, electrophysiological indices show reduced early- and heightened late-onset inhibitory brain activity, especially in the reward condition. Additionally, greater right frontal activity correlates with reduced early-onset and increased late-onset inhibitory brain activity. [ABSTRACT FROM AUTHOR]

The neural network mediating successful response inhibition mainly includes right hemisphere activation of the pre‐supplementary motor area, inferior frontal gyrus (IFG), subthalamic nucleus (STN), and caudate nucleus. However, the causal role of these regions in the inhibitory network is undefined. Five patients with Parkinson's disease were assessed prior to and after therapeutic thermal ablation of the right STN in two separate functional magnetic resonance imaging (fMRI) sessions while performing a stop‐signal task. Initiation times were faster but motor inhibition with the left hand (contralateral to the lesion) was significantly impaired as evident in prolonged stop‐signal reaction times. Reduced inhibition after right subthalamotomy was associated (during successful inhibition) with the recruitment of basal ganglia regions outside the established inhibitory network. They included the putamen and caudate together with the anterior cingulate cortex and IFG of the left hemisphere. Subsequent network connectivity analysis (with the seed over the nonlesioned left STN) revealed a new inhibitory network after right subthalamotomies. Our results highlight the causal role of the right STN in the neural network for motor inhibition and the possible basal ganglia mechanisms for compensation upon losing a key node of the inhibition network. [ABSTRACT FROM AUTHOR]

This article describes primary data and resources available from the Boston Adolescent Neuroimaging of Depression and Anxiety (BANDA) study, a novel arm of the Human Connectome Project (HCP). Data were collected from 215 adolescents (14–17 years old), 152 of whom had current diagnoses of anxiety and/or depressive disorders at study intake. Data include cross-sectional structural (T1- and T2-weighted), functional (resting state and three tasks), and diffusion-weighted magnetic resonance images. Both unprocessed and HCP minimally-preprocessed imaging data are available within the data release packages. Adolescent and parent clinical interview data, as well as cognitive and neuropsychological data are also included within these packages. Release packages additionally provide data collected from self-report measures assessing key features of adolescent psychopathology, including: anxious and depressive symptom dimensions, behavioral inhibition/activation, exposure to stressful life events, and risk behaviors. Finally, the release packages include 6- and 12-month longitudinal data acquired from clinical measures. Data are publicly accessible through the National Institute of Mental Health Data Archive (ID: #2505). [ABSTRACT FROM AUTHOR]

Artificial intelligence (AI) in business coaching, as in other human resource development professional service roles, opens up the possibility of multiple chances, such as cost- and time-effective gains. However, as AI can act autonomously and may surpass human performance, it can both lead to unforeseen risks as well as create a threat for professional service workers, including business coaches. Using a within-subject threat manipulation design, the present research investigated whether business coaches (N = 436; from over 50 different countries) respond to the topic of AI in coaching with heightened threat-related affective states and how this change affects their attitude towards the topic. Expectedly, the topic evoked higher behavioral inhibition and lower behavioral activation threat-related affective states, leading to lower curiosity in and a more negative opinion of AI in coaching. Theoretical and practical implications are addressed to lower the coaches' threat-related affective states towards AI application in professional services. A hybrid approach between responsible AI and an ethically skilled and professionally trained coach is recommended. [ABSTRACT FROM AUTHOR]

Research Findings: There are sparse data on children's use of executive function (EF) and spatial skills in block play. However, there are important implications for studying EF and spatial skills with blocks across cultures, especially regarding best practices for supporting social-cognitive development in under-resourced populations and consideration of culturally unique customs and practices. Therefore, the current study compared EF-based skills and spatial block building behaviors in Canadian and Tzotzil Maya children. Participants included 82 preschoolers (55% Canadian) ages 48–59 months (M age = 54.37 months, SD = 3.37) observed and coded during a group block play session with peers. Controlling for demographic covariates, a composite EF-based variable including six behaviors (intentional selection of blocks, taking time, response inhibition, replacing/moving blocks, stabilizing, aligning) was significantly and positively associated with spatial configurations in block structures (symmetry, β =.34; tiered orientation, β =.37) The associations did not vary by culture. Practice or Policy: Results provide new knowledge about use of EF-based skills and spatial skills in an ecologically valid context and implications for cross-cultural measurement and practice. [ABSTRACT FROM AUTHOR]

Objective: We sought to describe fluid cognition and its correlates among individuals with systemic lupus erythematosus (SLE). Methods: Participants (n = 199) were recruited from a population‐based cohort for a single study visit (October 2019 to May 2022). Fluid cognition was measured via the National Institutes of Health Toolbox Fluid Cognition Battery (including episodic memory, working memory, attention and inhibitory control, processing speed, and cognitive flexibility domains) and expressed as age‐corrected standard scores (mean 100, SD 15). Potential impairment was defined as a standard score >1.5 SD below the mean. Descriptive statistics were calculated and associations of various participant characteristics with the potential fluid cognition impairment were assessed with multivariable logistic regression. Results: Participants' mean age was 46.1 years; most were female (87.4%), Black (86.4%), and non‐Hispanic (95.0%). The mean overall fluid cognition score was 87.2; of the individual domains, the participants' mean score was lowest on attention and inhibitory control (82.0). Working status (odds ratio [OR] 0.30, 95% confidence interval [CI] 0.14–0.64) and higher self‐reported physical functioning (OR 0.46, 95% CI 0.28–0.75) and physical performance (OR 0.72, 95% CI 0.59–0.87) were associated with lower odds of fluid cognition impairment; lower educational attainment was associated with higher odds (OR 3.82, 95% CI 1.67–8.75). Self‐reported forgetfulness, neuropsychiatric damage, and depressive symptoms were not statistically significantly associated with potential impairment. Conclusion: Fluid cognition and, particularly, attention and inhibitory control were low in those with SLE relative to the general US population. Working status, higher physical functioning and performance, and higher educational attainment were associated with lower prevalence of potential impairment. Future work is needed to develop and implement interventions to help support cognition in individuals with SLE. [ABSTRACT FROM AUTHOR]

This study explores the effects of the two‐generation program CareerAdvance—which combines education and training for parents in healthcare with Head Start for children—on children's academic, language, mathematics, and inhibitory control followed for 3 years. The sample (collected in Tulsa, Oklahoma from 2011 to 2018) includes 147 children in the CareerAdvance group and 139 children in a matched comparison group (n = 286; 40% Black, 17%, White, 10% Hispanic, 33% Mixed Race, or Other Race; M = 3.6 years old; 47% female). Overall, the effect of CareerAdvance on child outcomes is neither greater nor less than Head Start alone. These findings suggest that children's developmental outcomes do not worsen or improve in the short term when their parents return to school. [ABSTRACT FROM AUTHOR]

Background: Poor self-control is a strong correlate of criminal propensity. It is conceptualized and operationalized differently in criminology than in other scientific traditions. Aims: (1) To verify the dimensionality of the criminological Grasmick selfcontrol items, other self-regulation items and morality ones. (2) To re-interpret the dimensions using a clinical perspective, a taxonomic/diagnostic model and references to possible "biological underpinnings." (3) Validate the dimensions by associations with crime. Method: Population: all persons born 1995 in Malmö and living there at age 12. A random sample (N = 525) filled in a comprehensive self-report questionnaire on themes like personality, crime/abuse and social aspects at age 15, 16 and 18. Age 18 data were analysed: 191 men and 220 women. Results: Self-regulation items were 4-dimensional: ADHD problems (Behavior control and Executive skills) and two Aggression factors. Morality items formed a fifth dimension. Negative Affect and Social interaction factors covered the rest of the variance. The validity of these factors was backed up by correlations with similar items/factors. Self-regulation subscales predicted crimes better than the Grasmick scale; an interaction with morality improved prediction still further. Sex differences were over-all small with three exceptions: Aggression, Morality and Negative affect. Conclusion: We identified four dimensions of the 20-item Grasmick instrument: Cognitive action control (impulsiveness/sensation seeking, response inhibition), Executive skills/future orientation, Affective/aggression reactivity and Aggression control. All should be possible to link to brain functional modules. Much can be gained if we are able to formulate an integrated model of self-regulation including distinct brain functional modules, process-and trait-oriented models, relevant diagnoses and clinical experiences of individual cases. [ABSTRACT FROM AUTHOR]

The Continuous Visual Attention Test (CVAT) is a test that detects visuomotor reaction time (RT, alertness), variability of reaction time (VRT, sustained attention), omission errors (OE, focused attention), and commission errors (CE, response inhibition). The standard test takes 15 min, while the ultrafast version only 90 s. Besides overall task length, the two versions differ by target probability (20% and 80% in the 15-min vs. only 80% in the 90-s test) and stimulus-onset asynchrony (SOA) (1, 2, and 4 s in the 15-min vs. only 1 s in the 90-s test. We aimed to analyze the effect of target probability, SOA, and time length on the CVAT variables across the 15-min task and to verify correlations and agreements between the 15-min and the 90-s CVATs. 205 healthy participants performed the two CVATs on the same day. Considering the 15-min task, RT and CE were strongly affected by target probability. Conversely, VRT was not affected. When the 15-min task was compared to the 90-s task, we found no significant difference in the VRT variable. Additionally, a significant agreement between the two tasks was found for the VRT variable. We concluded that sustained attention can be measured with the 90-s CVAT. [ABSTRACT FROM AUTHOR]

Cognitive skills, such as innovative problem-solving, are hypothesized to aid animals in urban environments. However, the significance of innovation in wild populations, and its expression across individuals and socio-ecological conditions, is poorly understood. To identify how and when innovation arises in urban-dwelling species, we used advanced technologies and new testing and analytical methods to evaluate innovative problem-solving abilities of wild raccoons (Procyon lotor). We deployed multi-compartment puzzle boxes with either one or multiple solution types and identified raccoons using radio frequency identification. Raccoons solved these novel extractive foraging tasks, and their success was influenced by age and exploratory diversity. Successful raccoons always discovered multiple different solution types, highlighting flexible problem-solving. Using a unique, comparative sequence analysis approach, we found that variation in raccoon solving techniques was greater between individuals than within individuals, and this self-similarity intensified during times of competition. Finally, the inclusion of an easier solution in the multi-solution trials enabled previously unsuccessful raccoons to bootstrap their learning and successfully open multiple difficult solutions. Our study suggests that innovative problem-solving is probably influenced by many factors and has provided novel field and analytical methods, as well as new insights on the socio-ecological dynamics of urban populations. [ABSTRACT FROM AUTHOR]

The MAPK signaling pathway with BRAF mutations has been shown to drive the pathogenesis of 40–60% of melanomas. Inhibitors of this pathway's BRAF and MEK components are currently used to treat these malignancies. However, responses to these treatments are not always successful. Therefore, identifying noninvasive biomarkers to predict treatment responses is essential for personalized medicine in melanoma. Using noninvasive 1H magnetic resonance spectroscopy (1H MRS), we previously showed that BRAF inhibition reduces lactate and alanine tumor levels in the early stages of effective therapy and could be considered as metabolic imaging biomarkers for drug response. The present work demonstrates that these metabolic changes observed by 1H MRS and those assessed by 31P MRS are also found in preclinical human melanoma models treated with MEK inhibitors. Apart from 1H and 31P MRS, additional supporting in vitro biochemical analyses are described. Our results indicate significant early metabolic correlations with response levels to MEK inhibition in the melanoma models and are consistent with our previous study of BRAF inhibition. Given these results, our study supports the potential clinical utility of noninvasive MRS to objectively image metabolic biomarkers for the early prediction of melanoma's response to MEK inhibition. [ABSTRACT FROM AUTHOR]

Introduction: Transcranial direct current stimulation (tDCS) administers lowintensity direct current electrical stimulation to brain regions via electrodes arranged on the surface of the scalp. The core promise of tDCS is its ability to modulate brain activity and affect performance on diverse cognitive functions (affording causal inferences regarding regional brain activity and behavior), but the optimal methodological parameters for maximizing behavioral effects remain to be elucidated. Here we sought to examine the effects of 10 stimulation and experimental design factors across a series of five cognitive domains: motor performance, visual search, working memory, vigilance, and response inhibition. The objective was to identify a set of optimal parameter settings that consistently and reliably maximized the behavioral effects of tDCS within each cognitive domain. Methods: We surveyed tDCS effects on these various cognitive functions in healthy young adults, ultimately resulting in 721 effects across 106 published reports. Hierarchical Bayesian meta-regression models were fit to characterize how (and to what extent) these design parameters differentially predict the likelihood of positive/negative behavioral outcomes. Results: Consistent with many previous meta-analyses of tDCS effects, extensive variability was observed across tasks and measured outcomes. Consequently, most design parameters did not confer consistent advantages or disadvantages to behavioral effects--a domain-general model suggested an advantage to using within-subjects designs (versus between-subjects) and the tendency for cathodal stimulation (relative to anodal stimulation) to produce reduced behavioral effects, but these associations were scarcely-evident in domainspecific models. Discussion: These findings highlight the urgent need for tDCS studies to more systematically probe the effects of these parameters on behavior to fulfill the promise of identifying causal links between brain function and cognition. [ABSTRACT FROM AUTHOR]

Background: Telmisartan, a potent angiotensin II type-1 receptor blocker as well as partial PPAR–gamma agonist, has emerged as a versatile therapeutic agent with diverse pharmacological actions beyond its primary indication for essential hypertension. This review explores the complex mechanisms of action of telmisartan and clarifies its effectiveness in an inflammation, cancer, metabolic, and CNS disorders. Main body: Telmisartan inhibits many biochemical processes involved in the control of the cardiovascular system, such as vascular smooth muscle contraction, aldosterone production, and sympathetic tone modulation, by specifically targeting the angiotensin II type-1 receptor. Its distinct partial agonist action toward peroxisome proliferator-activated receptor gamma also imparts anti-inflammatory, antiproliferative, and antioxidant activities, making it a viable treatment for various diabetic patients who have atherosclerosis and myocardial infarction. Conclusion: Telmisartan's diverse pharmacological actions, encompassing anti-inflammatory, neuroprotective, nephroprotective, anticancer, and anti-anxiety properties, position it as a promising treatment option for a broad spectrum of medical conditions. [ABSTRACT FROM AUTHOR]

T-even bacteriophages are known to employ lysis inhibition (LIN), where the lysis of an infected host is delayed in response to secondary adsorptions. Upon the eventual burst of the host, significantly more phage progenies are released. Here, we analysed the competitive advantage of LIN using a mathematical model. In batch culture, LIN provides a bigger phage yield at the end of the growth where all the hosts are infected due to an exceeding number of phage particles and, in addition, gives a competitive advantage against LIN mutants with rapid lysis by letting them adsorb to already infected hosts in the LIN state. By simulating plaque formation in a spatially structured environment, we show that, while LIN phages will produce a smaller zone of clearance, the area over which the phages spread is actually comparable to those without LIN. The analysis suggests that LIN induced by secondary adsorption is favourable in terms of competition, both in spatially homogeneous and inhomogeneous environments. Author summary: T-even bacteriophages can delay the lysis of their hosts when they detect more phages are adsorbing to the hosts. This behaviour is called lysis inhibition. While the delay slows down the rate at which phage progeny comes out from an infected host, it allows the phage to increase the progeny production per host. Using a mathematical model, we provide a quantitative analysis of this strategy's competitive advantages and disadvantages in different environments. The model predicts that phage adsorption to lysis-inhibited cells provides a significant competitive advantage to lysis-inhibiting phage against phages that quickly lyse the cells. We also find that secondary infection-triggered delay does not hinder the spreading of the phage in a lawn of uninfected cells, even though the apparent plaque size, i.e., a zone that appears clear because cells have been lysed, is small. The analysis suggests that lysis inhibition provides a robust competitive advantage for a virulent phage. [ABSTRACT FROM AUTHOR]

Objective: To explore the relationship among boredom proneness, the behavioral inhibition system, and anxiety among college students based on variable-centered and person-centered analytic approaches. Methods: A questionnaire survey was conducted on 1,102 college students from a university in Hebei Province using the Boredom Proneness Questionnaire (BPQ) for College Students, the Behavioral Inhibition System Scale (BIS), and the General Anxiety Disorder-7 scale (GAD-7). Results: The results reveal that boredom proneness was negatively correlated with scores on the behavioral inhibition system (r=-0.100, p<0.01), and positively correlated with anxiety (r = 0.457, p< 0.001), while the behavioral inhibition system was positively correlated with anxiety (r= 0.086, p<0.01). In the variable-centered analyses study, it was found that the behavioral inhibition system partially mediated the association between boredom proneness and anxiety. In the person-centered analyses study, three subtypes were identified: the high boredom-low inhibition group (9.35%), the moderate boredom-inhibition group (66.70%), and the low boredom-high inhibition group (23.95%). Individuals in these subtypes showed significant differences in anxiety scores (F= 4.538, p<0.05), with the low boredom-high inhibition group scoring the highest. Conclusion: The results showed that the behavioral inhibition system partially mediates the relationship between boredom proneness and anxiety in college students; boredom proneness and the behavioral inhibition system exhibit group heterogeneity, with distinct classification features closely related to anxiety. [ABSTRACT FROM AUTHOR]

Background and aims: Anorexia nervosa (AN) is a complex neuropsychiatric disorder. This systematic review synthesizes evidence from diverse studies to assess and investigate the association between gene polymorphisms and psychological and neurobiological factors in patients with AN. Methods: A systematic search across PubMed, PsycINFO, Scopus, and Web of Science databases, along with manual searching, was conducted. The review protocol was approved by PROSPERO (CRD42023452548). Out of 1,250 articles, 11 met the inclusion criteria. The quality of eligible articles was assessed using the Newcastle-Ottawa Scale (NOS) tool. The systematic review followed the PRISMA guidelines. Results: The serotoninergic system, particularly the 5-HTTLPR polymorphism, is consistently linked to altered connectivity in the ventral attention network, impaired inhibitory control, and increased susceptibility to AN. The 5-HTTLPR polymorphism affects reward processing, motivation, reasoning, working memory, inhibition, and outcome prediction in patients with AN. The dopaminergic system, involving genes like COMT, DRD2, DRD3, and DAT1, regulates reward, motivation, and decision-making. Genetic variations in these dopaminergic genes are associated with psychological manifestations and clinical severity in patients with AN. Across populations, the Val66Met polymorphism in the BDNF gene influences personality traits, eating behaviors, and emotional responses. Genes like OXTR, TFAP2B, and KCTD15 are linked to social cognition, emotional processing, body image concerns, and personality dimensions in patients with AN. Conclusion: There was an association linking multiple genes to the susceptibly and/or severity of AN. This genetic factor contributes to the complexity of AN and leads to higher diversity of its clinical presentation. Therefore, conducting more extensive research to elucidate the underlying mechanisms of anorexia nervosa pathology is imperative for advancing our understanding and potentially developing targeted therapeutic interventions for the disorder. [ABSTRACT FROM AUTHOR]

Reward processing dysfunction and inhibition control deficiency have been observed in Internet gaming disorder (IGD). However, it is still unclear whether the previous reinforcement learning depends on reward/punishment feedback influences on the cognitive inhibitory control of IGD. This study compared the differences between an IGD group and healthy people without game experiences in the probability selection task and the subsequent stop signal task by the method of behavioral experiments, in order to explore whether the reward learning ability is impaired in the IGD group. We also discuss the influence of previous reward learning on subsequent inhibition control. The results showed that (1) during the reward learning phase, the IGD group's accuracy was significantly lower than that of the control group; (2) compared with the control group, the IGD group's reaction times were longer in the transfer phase; (3) for no‐go trials of the inhibitory control phase after reward learning, the accuracy of the reward‐related stimulation in the IGD group was lower than that of punishment‐related or neutral stimulation, but there was no significant difference among the three conditions in the control group. These findings indicated that the reinforcement learning ability of the IGD group was impaired, which further caused the abnormal response to reinforcement stimuli. [ABSTRACT FROM AUTHOR]

Neuromodulation was utilized here to investigate the distinct involvement of two recognized cortical hubs for semantic integration (the left anterior temporal lobe, lATL) and inhibitory control (the right dorsolateral prefrontal cortex, rDLPFC) in creative problem-solving. Participants were presented with a list of category-exemplar words, selectively recalled some of them, and then solved a set of RAT problems. Selective retrieval was introduced to trigger inhibitory control over competitors. Critically, some RAT problems could be solved with words from the previous phases of the experiment, including words that might be less accessible due to inhibition. Other problems, however, could only be solved with unpresented words. Experiment 1 showed that anodal tDCS over the lATL had a negative effect on the production of correct responses to baseline RAT problems, but not on those that required inhibited solutions. Experiment 2 produced the reverse pattern with cathodal tDCS over the rDLPFC. Resting-state EEG recordings were obtained before and after delivering tDCS, which also revealed specific tDCS-induced changes in frequency bands depending on the site of stimulation. Overall, these findings provide support for the involvement of semantic and control processes in creative problem solving that are linked to different brain networks. [ABSTRACT FROM AUTHOR]

Research reveals that while uncontaminated eyewitness recall can be reliable, delayed trials make memory contamination inevitable. This study assessed the authenticity of eyewitness recall using neuro signature profiling. It examined the effects of negative feedback and leading questions on Experiential Knowledge (EK). Sixty participants with matched cognitive flexibility and response inhibition underwent two BEOS profiling sessions, fifteen days apart, after a real-life simulation. The findings showed no discernible change in EK for any of the three groups between the pre-and post-test conditions. Thus, affirming Neuro Signature Profiling as an effective technique for determining the veracity of eyewitness recall. [ABSTRACT FROM AUTHOR]

Background Aim Methods Results Conclusion Cognitive impairment is one of the most common symptoms of Parkinson's disease (PD). In recent years, the effect of transcranial direct current stimulation (tDCS) have been investigated on various disabilities related to PD, including sensory and motor deficits and fatigue.To investigate effects of transcranial direct current stimulation (tDCS) along with cognitive training on attention, working memory, reaction time (RTI), response inhibition, and activities of daily living performance.This pilot randomized, single‐blinded, and sham‐controlled trial was performed on 32 people with PD who were blocked randomized equally into intervention and control groups. Intervention group received ten 20‐min sessions of tDCS during ten 45‐min sessions of cognitive training, while control group received ten 20‐min sessions of sham‐tDCS during ten 45‐min sessions of cognitive training. Anodal electrode of tDCS (2 mA) was placed over left dorsolateral prefrontal cortex (DLPFC), while cathode was over right supraorbital region. A blinded assessor performed pretest, posttest, and follow‐up assessments using the Unified Parkinson's Disease Rating Scale and four subtests of the CANTAB computer test including Match to Sample Visual Search, spatial span task, stop signal task, and RTI.The results showed significant differences within groups over time in the mean scores of attention (F = 24.73, p = 0.00), working memory (F = 19.06, p = 0.000), RTI (F = 8.63, p = 0.005), response inhibition (F = 15.75, p = 0.000), and activity of daily living performance (F = 6.73, p = 0.013).tDCS (anodal electrode over the left DLPFC and cathodal electrode over the right supraorbital region) along with cognitive training could facilitate improvement of cognitive functions and activities of daily living performance compared to routine cognitive exercises in people with PD. [ABSTRACT FROM AUTHOR]

Introduction: Response inhibition is an impaired cognitive function in attention-deficit/ hyperactivity disorder (ADHD) individuals. This primary deficit during the cancelation of an intended movement is observed even in the minimal demanding cognitive tasks. Studies have shown that transcranial magnetic stimulation (TMS), especially on the dorsolateral prefrontal cortex (DLPFC), can improve response inhibition. Nevertheless, TMS has a low spatial resolution, and its effect may not be observed in a single-session intervention. Studies show that low-intensity TMS has higher spatial resolution. Therefore, in this study, we aimed to evaluate the effectiveness of this method for intervention of response inhibition in ADHD individuals. Methods: In a double-blind paradigm, the performance of the adults with ADHD while executing a Stroop color and word test (SCWT) was measured during a sham or a real stimulation of the DLPFC. Subsequently, the response inhibitions of the participants were measured before and after the stimulation. The number of correct, wrong, and missed answers to 96 computerized trials and the response times of the answers were measured. In addition, changes in electrocortical activities during the rest phase before and after the stimulation were also evaluated. Results: After checking for data normality, the paired t-test between behavioral data showed that low-intensity magnetic stimulation of the DLPFC can improve response inhibition (reduce errors) even in a single-session intervention of ADHD individuals. The answering times did not change significantly. The behavioral changes were associated with significant changes in the power of EEG in delta and beta frequency bands at the frontal areas. Conclusion: The proposed stimulation protocol with low-intensity TMS had a fair effect on the response inhibition in adults with ADHD. Therefore, it could be suggested as a treatment protocol for response inhibition in ADHD individuals. [ABSTRACT FROM AUTHOR]

Background: Research utilizing experimental tasks usually does not report estimates of internal reliability of measurement. However, modern measurement theories conceptualize reliability as sample dependent indicating that reliability should be empirically demonstrated in the samples used to make inferences. Objectives: Test whether confirmatory factor analytic (CFA) estimates of reliability can be applied to a commonly used task measuring response inhibition (the Stop Signal Task) to predict substance use (alcohol and cannabis) and mental health symptoms. Methods: Thirty-seven participants between the ages of 18–20 (72% female; 16% Asian, 3% Native American, 11% Black or African American, 59% White; 32% Latino/a/x) were recruited via social media advertisement and attended a laboratory visit. The Stop Signal Reaction Time (SSRT) was calculated as the outcome for three experimental blocks and used as indicators in a CFA. Results: CFA suggests the task yields reliable scores; factor loadings were statistically significant (p <.05) and substantial (standardized loadings ranged from.74 to.94). However, reliability increased across experimental blocks and error was non-trivial (ranging from 50% to 12% of the variance). The inhibition factor predicted higher maximum number of drinks consumed (β =.37, p <.05), higher frequency of cannabis use (β =.39, p <.05), and more cannabis use occasions within using days (β =.40, p <.05), as well as facets of mental health (anxious/depression, attention, and anxiety problems; all p's <.05). Conclusion: Results support the utility of CFA to test for reliability of measurement, with the ability to inhibit dominant responses serving as a transdiagnostic correlate of substance use and mental health problems. [ABSTRACT FROM AUTHOR]