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151. Case-Control Genome-Wide Association Study of Attention-Deficit/Hyperactivity Disorder

Author

Neale, Benjamin M., Medland, Sarah, Ripke, Stephan, Anney, Richard J.L., Asherson, Philip, Buitelaar, Jan, Franke, Barbara, Gill, Michael, Kent, Lindsey, Holmans, Peter, Middleton, Frank, Thapar, Anita, Lesch, Klaus-Peter, Faraone, Stephen V., Daly, Mark, Nguyen, Thuy Trang, Schäfer, Helmut, Steinhausen, Hans-Christoph, Reif, Andreas, Renner, Tobias J., Romanos, Marcel, Romanos, Jasmin, Warnke, Andreas, Walitza, Susanne, Freitag, Christine, Meyer, Jobst, Palmason, Haukur, Rothenberger, Aribert, Hawi, Ziarih, Sergeant, Joseph, Roeyers, Herbert, Mick, Eric, and Biederman, Joseph

Published
2010
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152. Identifying Loci for the Overlap Between Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Using a Genome-wide QTL Linkage Approach

Author

Nijmeijer, Judith S., Arias-Vásquez, Alejandro, Rommelse, Nanda N.J., Altink, Marieke E., Anney, Richard J.L., Asherson, Philip, Banaschewski, Tobias, Buschgens, Cathelijne J.M., Fliers, Ellen A., Gill, Michael, Minderaa, Ruud B., Poustka, Luise, Sergeant, Joseph A., Buitelaar, Jan K., Franke, Barbara, Ebstein, Richard P., Miranda, Ana, Mulas, Fernando, Oades, Robert D., Roeyers, Herbert, Rothenberger, Aribert, Sonuga-Barke, Edmund J.S., Steinhausen, Hans-Christoph, Faraone, Stephen V., Hartman, Catharina A., and Hoekstra, Pieter J.

Published
2010
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153. A Peer-Mediated Proximity Intervention to Facilitate the Social Interactions of Children with a Pervasive Developmental Disorder.

Author

Roeyers, Herbert

Abstract

A peer-mediated intervention was used to improve the social skills of 3 children with autism (ages 5 to 13). The intervention paired each child with a nondisabled peer who initiated interaction persistently within the autistic children's usual school setting. The autistic children demonstrated more frequent interactions and more positive and appropriate behaviors following the intervention. (DB)

Published
1995

159. Author Correction: Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder (Nature Communications, (2021), 12, 1, (576), 10.1038/s41467-020-20443-2)

Author

Demontis, Ditte, Walters, Raymond K., Rajagopal, Veera M., Waldman, Irwin D., Grove, Jakob, Als, Thomas D., Dalsgaard, Søren, Ribasés, Marta, Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Maria, Werge, Thomas, Nordentoft, Merete, Mors, Ole, Mortensen, Preben Bo, Andreassen, Ole A., Arranz, Maria Jesús, Banaschewski, Tobias, Bau, Claiton, Bellgrove, Mark, Biederman, Joseph, Brikell, Isabell, Buitelaar, Jan K., Burton, Christie L., Casas, Miguel, Crosbie, Jennifer, Doyle, Alysa E., Ebstein, Richard P., Elia, Josephine, Elizabeth, Corfield C., Grevet, Eugenio, Grizenko, Natalie, Havdahl, Alexandra, Hawi, Ziarih, Hebebrand, Johannes, Hervas, Amaia, Hohmann, Sarah, Haavik, Jan, Joober, Ridha, Kent, Lindsey, Kuntsi, Jonna, Langley, Kate, Larsson, Henrik, Lesch, Klaus-Peter, Leung, Patrick W. L., Liao, Calwing, Loo, Sandra K., Martin, Joanna, Martin, Nicholas G., Medland, Sarah E., Miranda, Ana, Mota, Nina Roth, Oades, Robert D., Ramos-Quiroga, Josep Antoni, Reif, Andreas, Rietschel, Marcella, Roeyers, Herbert, Rohde, Luis Augusto, Rothenberger, Aribert, Rovira, Paula, Sánchez-Mora, Cristina, Schachar, Russell James, Sengupta, Sarojini, Artigas, Maria Soler, Steinhausen, Hans-Christoph, Thapar, Anita, Witt, Stephanie H., Yang, Li, Zayats, Tetyana, Zhang-James, Yanli, Cormand, Bru, Hougaard, David M., Neale, Benjamin M., Franke, Barbara, Faraone, Stephen V., and Børglum, Anders D.

Subjects
Medizin
Abstract

The original version of this Article contained an error in the spelling of the author Marta Ribasés, which was incorrectly given as Marta Ribasas. This has now been corrected in both the PDF and HTML versions of the Article. CA extern, Korrektur zu: 10.1038/s41467-020-20443-2

Published
2021

160. Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

Author

Demontis, Ditte, Walters, Raymond K., Rajagopal, Veera M., Waldman, Irwin D., Grove, Jakob, Als, Thomas D., Dalsgaard, Søren, Ribasas, Marta, Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Maria, Werge, Thomas, Nordentoft, Merete, Mors, Ole, Mortensen, Preben Bo, (PGC), ADHD Working Group of the Psychiatric Genomics Consortium, Andreassen, Ole A., Arranz, Maria Jesús, Banaschewski, Tobias, Bau, Claiton, Bellgrove, Mark, Biederman, Joseph, Brikell, Isabell, Buitelaar, Jan K., Burton, Christie L., Casas, Miguel, Crosbie, Jennifer, Doyle, Alysa E., Ebstein, Richard P., Elia, Josephine, Elizabeth, Corfield C., Grevet, Eugenio, Grizenko, Natalie, Havdahl, Alexandra, Hawi, Ziarih, Hebebrand, Johannes, Hervas, Amaia, Hohmann, Sarah, Haavik, Jan, Joober, Ridha, Kent, Lindsey, Kuntsi, Jonna, Langley, Kate, Larsson, Henrik, Lesch, Klaus-Peter, Leung, Patrick W. L., Liao, Calwing, Loo, Sandra K., Martin, Joanna, Martin, Nicholas G., Medland, Sarah E., Miranda, Ana, Mota, Nina Roth, Oades, Robert D., Ramos-Quiroga, Josep Antoni, Reif, Andreas, Rietschel, Marcella, Roeyers, Herbert, Rohde, Luis Augusto, Rothenberger, Aribert, Rovira, Paula, Sánchez-Mora, Cristina, Schachar, Russell James, Sengupta, Sarojini, Artigas, Maria Soler, Steinhausen, Hans-Christoph, Thapar, Anita, Witt, Stephanie H., Yang, Li, Zayats, Tetyana, Zhang-James, Yanli, Cormand, Bru, Hougaard, David M., Neale, Benjamin M., Franke, Barbara, Faraone, Stephen V., Børglum, Anders D., University of St Andrews. School of Medicine, University of St Andrews. Institute of Behavioural and Neural Sciences, University of St Andrews. Cellular Medicine Division, Institut Català de la Salut, [Demontis D, Rajagopal VM, Als TD] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark. Center for Genomics and Personalized Medicine, Aarhus, Denmark. Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark. [Walters RK] Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [Waldman ID] Department of Psychology, Emory University, Atlanta, GA, USA. [Grove J] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark. Center for Genomics and Personalized Medicine, Aarhus, Denmark. Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark. [Ribasés M] Unitat de Psiquiatria Genètica, Grup de recerca en Psiquiatria, salut mental i addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Biomedical Network Research Center on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Catalonia, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Male, 0301 basic medicine, Multifactorial Inheritance, Trastorns per dèficit d'atenció amb hiperactivitat en els infants, Medizin, General Physics and Astronomy, Genome-wide association study, Comorbidity, Genome-wide association studies, Attention deficit disorder with hyperactivity in children, conducta y mecanismos de la conducta::conducta::conducta y mecanismos de la conducta::conducta::conducta infantil::conducta problemática [PSIQUIATRÍA Y PSICOLOGÍA], Cohort Studies, 0302 clinical medicine, Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity [PSYCHIATRY AND PSYCHOLOGY], Risk Factors, 2.1 Biological and endogenous factors, Medicine, Attention Deficit Disorder with Hyperactivity/epidemiology, Aetiology, Child, China/epidemiology, Violence Research, Pediatric, Multidisciplinary, Genetic Predisposition to Disease/genetics, Attention Deficit and Disruptive Behavior Disorders/epidemiology, Single Nucleotide, 3. Good health, Europe, Mental Health, Attention Deficit and Disruptive Behavior Disorders, Cohort, Genome-Wide Association Study/methods, Attention Deficit Disorder (ADD), Female, medicine.symptom, RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry, Clinical psychology, China, Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Genome-Wide Association Study [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Science, Context (language use), Locus (genetics), QH426 Genetics, Polymorphism, Single Nucleotide, behavioral disciplines and activities, Article, General Biochemistry, Genetics and Molecular Biology, Europe/epidemiology, 03 medical and health sciences, Aggressiveness in children, Behavioral and Social Science, mental disorders, Genetics, ADHD, Humans, SNP, Attention deficit hyperactivity disorder, Genetic Predisposition to Disease, Polymorphism, Author Correction, QH426, Multifactorial Inheritance/genetics, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], business.industry, Aggression, Prevention, Human Genome, DAS, General Chemistry, Agressivitat en els infants, Heritability, medicine.disease, Attention Deficit Hyperactivity Disorder (ADHD), Behavior and Behavior Mechanisms::Behavior::Behavior and Behavior Mechanisms::Behavior::Child Behavior::Problem Behavior [PSYCHIATRY AND PSYCHOLOGY], Brain Disorders, Genòmica, ADHD Working Group of the Psychiatric Genomics Consortium, Trastorn per dèficit d'atenció amb hiperactivitat, 030104 developmental biology, Attention Deficit Disorder with Hyperactivity, técnicas de investigación::métodos epidemiológicos::diseño de la investigación epidemiológica::estudio de asociación genómica completa [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], RC0321, trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad [PSIQUIATRÍA Y PSICOLOGÍA], business, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10−10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h2SNP = 0.34) when compared to ADHD without DBDs (h2SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (rg = 0.81) and anti-social behaviors (rg = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior., ADHD is often found to be comorbid with disruptive behavior disorders, but the genetic loci underlying this comorbidity are unknown. Here, the authors have performed a GWAS meta-analysis of ADHD with disruptive behavior disorders, finding three genome-wide significant loci in Europeans, and replicating one in a Chinese cohort.

Published
2021

167. Separation of cognitive impairments in attention-deficit/hyperactivity disorder into 2 familial factors

Author

Kuntsi, Joanna, Wood, Alexis C., Rijsdijk, Fruhling, Johnson, Katherine A., Andreou, Penelope, Albrecht, Bjorn, Arias-Vasquez, Alejandro, Buitelaar, Jan K., McLoughlin, Grainne, Rommelse, Nanda N.J., Sergeant, Joseph A., Sonuga-Barke, Edmund J., Uebel, Henrik, van der Meere, Jaap J., Banaschewski, Tobias, Gill, Michael, Manor, Iris, Miranda, Ana, Mulas, Fernando, Oades, Robert D., Roeyers, Herbert, Rothenberger, Aribert, Steinhausen, Hans-Christoph, Faraone, Stephen V., and Asherson, Philip

Subjects
Attention-deficit hyperactivity disorder -- Development and progression, Attention-deficit hyperactivity disorder -- Genetic aspects, Attention-deficit hyperactivity disorder -- Research, Cognition disorders -- Development and progression, Cognition disorders -- Genetic aspects, Cognition disorders -- Research, Health, Psychology and mental health
Published
2010

170. Stimulant treatment for ADHD

Author

Groenman, Annabeth P., Oosterlaan, Jaap, Rommelse, Nanda N. J., Franke, Barbara, Greven, Corina U., Hoekstra, Pieter J., Hartman, Catharina A., Luman, Marjolein, Roeyers, Herbert, Oades, Robert D., Sergeant, Joseph A., Buitelaar, Jan K., and Faraone, Stephen V.

Published
2014

172. Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders

Author

Mulligan, Aisling, Anney, Richard J. L., O’Regan, Myra, Chen, Wai, Butler, Louise, Fitzgerald, Michael, Buitelaar, Jan, Steinhausen, Hans-Christoph, Rothenberger, Aribert, Minderaa, Ruud, Nijmeijer, Judith, Hoekstra, Pieter J., Oades, Robert D., Roeyers, Herbert, Buschgens, Cathelijne, Christiansen, Hanna, Franke, Barbara, Gabriels, Isabel, Hartman, Catharina, Kuntsi, Jonna, Marco, Rafaela, Meidad, Sheera, Mueller, Ueli, Psychogiou, Lamprini, Rommelse, Nanda, Thompson, Margaret, Uebel, Henrik, Banaschewski, Tobias, Ebstein, Richard, Eisenberg, Jacques, Manor, Iris, Miranda, Ana, Mulas, Fernando, Sergeant, Joseph, Sonuga-Barke, Edmund, Asherson, Phil, Faraone, Stephen V., and Gill, Michael

Published
2009
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180. Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments

Author

Vainieri, Isabella, primary, Martin, Joanna, additional, Rommel, Anna-Sophie, additional, Asherson, Philip, additional, Banaschewski, Tobias, additional, Buitelaar, Jan, additional, Cormand, Bru, additional, Crosbie, Jennifer, additional, Faraone, Stephen V., additional, Franke, Barbara, additional, Loo, Sandra K., additional, Miranda, Ana, additional, Manor, Iris, additional, Oades, Robert D., additional, Purves, Kirstin L., additional, Ramos-Quiroga, J. Antoni, additional, Ribasés, Marta, additional, Roeyers, Herbert, additional, Rothenberger, Aribert, additional, Schachar, Russell, additional, Sergeant, Joseph, additional, Steinhausen, Hans-Christoph, additional, Vuijk, Pieter J., additional, Doyle, Alysa E., additional, and Kuntsi, Jonna, additional

Published
2021
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184. Association between DRD2/DRD4 interaction and conduct disorder: A potential developmental pathway to alcohol dependence

Author

Mota, Nina R., Bau, Claiton H. D., Banaschewski, Tobias, Buitelaar, Jan K., Ebstein, Richard P., Franke, Barbara, Gill, Michael, Kuntsi, Jonna, Manor, Iris, Miranda, Ana, Mulas, Fernando, Oades, Robert D., Roeyers, Herbert, Rothenberger, Aribert, Sergeant, Joseph A., Sonuga-Barke, Edmund J., Steinhausen, Hans-Christoph, Faraone, Stephen V., and Asherson, Philip

Published
2013
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192. Perceptions of parents of the impact of autism spectrum disorder on their quality of life and correlates: comparison between mothers and fathers.

Author

Vernhet, Christelle, Michelon, Cécile, Dellapiazza, Florine, Rattaz, Cécile, Geoffray, Marie-Maude, Roeyers, Herbert, Picot, Marie-Christine, Baghdadli, Amaria, ELENA study group, Chabaux, Catherine, Chatel, Clarisse, Cohen, David, Damville, Emmanuel, Gicquel, Ludovic, Jardri, Renaud, Maffre, Thierry, Novo, Alexandre, Roxane, Roxane, Oreve, Marie-Joëlle, and Périsse, Didier

Abstract

Purpose: To compare mothers and fathers perceptions of the impact of autism spectrum disorder on their Quality of Life (QoL), we used the Parental-Developmental Disorders-Quality of Life scale (Par-DD-QoL). Method: The perception of QoL of mothers and fathers was compared for 130 pairs of parents of children with ASD and the associated variables were investigated. Results: Mothers perceived a significantly greater impact of ASD on their QoL than fathers. Parents perceived a higher impact of ASD on global QoL when their child's adaptive skills were low and when the level of aberrant behaviors was high. More precisely, the perception of QoL by the mothers was negatively associated with their child's internalized disorders, whereas the perception of QoL by the fathers was negatively associated with their child's externalized disorders. Neither the mothers' nor the fathers' perception of the impact on QoL was associated with their children's age or the severity of their autistic symptoms. Some parental factors, such as being members of a family association, having benefited from training in ASD and having experienced a disruption in professional activity were associated with a greater impact on their QoL. Conclusion: Our finding that the perceived impact of ASD on QoL differed between mothers and fathers argues for individualized psychosocial support. Moreover, the strong correlation between the child's clinical characteristics and the perception by parents of a higher impact of ASD on QoL should be seen as red flag concerning the needs of the parents in terms of social and educational support. Trial registration number: NCT02625116 (October 2015). [ABSTRACT FROM AUTHOR]

Published
2022
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194. Stimulation seeking and hyperactive behavior in children with ADHD: a re-analysis

Author

Antrop, Inge, Buysse, Ann, Roeyers, Herbert, and Van Oost, Paulette

Subjects
Attention-deficit hyperactivity disorder -- Case studies, Hyperactive children -- Behavior, Hyperactive children -- Case studies, Health, Psychology and mental health
Abstract

To examine the stimulation-seeking function of hyperactivity in children with ADHD, Antrop and colleagues analyzed the behavior of 30 hyperactive and 30 nonhyperactive children during a waiting situation, either with or without extra stimulation. The behavior was assessed by frequency measures. In their study it was hypothesized that children with ADHD would show a greater decrease in activity in the presence of stimulation than control children. Since confirmation for this hypothesis was only found for 2 of 25 target behaviors, the present re-analysis included other behavioral measures to assess two relationships: first, how hyperactivity varies under fixed time conditions, using measures of duration and intensity of behavior instead of frequency measures, and second, how the perceived duration of waiting time affects behavior. Analysis indicated that children with ADHD showed a greater decrease in behavior in the presence of stimulation for touching objects and movements of trunk, as reported. Further, children who underestimated the waiting period were more apt to seek additional stimulation in its absence than those who overestimated the waiting period.

Published
2002

195. EPA2000: assessing off-line metacognition in mathematical problem solving

Author

Desoete, Annemie, Roeyers, Herbert, and Clercq, Armand De

Subjects
Mathematics -- Study and teaching, Problem solving in children -- Psychological aspects, Metacognition -- Research
Abstract

Introduction Research from different theoretical approaches has provided information regarding processes that are important for young children to solve mathematical problems adequately (Donlan, 1998; Koriat, 1995; Lucangeli & Cornoldi, 1997; […]

Published
2002

196. Off-line metacognition--a domain-specific retardation in young children with learning disabilities?

Author

Desoete, Annemie and Roeyers, Herbert

Subjects
Metacognition -- Research -- Social aspects -- Study and teaching, Learning disabilities -- Research, Mathematics -- Study and teaching -- Research -- Social aspects, Education -- Social aspects -- United States, Education, Social aspects, Research, Study and teaching
Abstract

Abstract. Off-line metacognition (prediction and evaluation) was assessed in 437 normally intelligent children with or without learning disabilities in grades 2 and 3. Children with specific mathematics learning disabilities were [...]

Published
2002

197. Neuropsychological correlates of emotional lability in children with ADHD

Author

Banaschewski, Tobias, Jennen-Steinmetz, Christine, Brandeis, Daniel, Buitelaar, Jan K., Kuntsi, Jonna, Poustka, Luise, Sergeant, Joseph A., Sonuga-Barke, Edmund J., Frazier-Wood, Alexis C., Albrecht, Björn, Chen, Wai, Uebel, Henrik, Schlotz, Wolff, van der Meere, Jaap J., Gill, Michael, Manor, Iris, Miranda, Ana, Mulas, Fernando, Oades, Robert D., Roeyers, Herbert, Rothenberger, Aribert, Steinhausen, Hans-Christoph, Faraone, Stephen V., and Asherson, Philip

Published
2012
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199. Advancing advanced mind-reading tests: empathic accuracy in adults with a pervasive developmental disorder

Author

Roeyers, Herbert, Buysse, Ann, Ponnet, Koen, and Pichal, Bert

Subjects
Adults -- Testing, Autism -- Research, Empathy -- Research, Psychology and mental health
Abstract

A study of high-functioning adults with a pervasive developmental disorder is presented with emphasis on their empathic accuracy. Advanced mind-reading tests were used and the results of normal adults compared to this group.

Published
2001

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