425 results on '"Romano, Gaetano"'
Search Results
152. Overexpression of protectin (CD59) down-modulates the susceptibility of human melanoma cells to homologous complement
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Coral, Sandra, primary, Fonsatti, Ester, additional, Sigalotti, Luca, additional, De Nardo, Chiara, additional, Visintin, Alberto, additional, Nardi, Gianpaolo, additional, Colizzi, Francesca, additional, Colombo, Mario P., additional, Romano, Gaetano, additional, Altomonte, Maresa, additional, and Maio, Michele, additional
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- 2000
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153. Robotic lobectomy for lung cancer: evolution in technique and technology†.
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Melfi, Franca M.A., Fanucchi, Olivia, Davini, Federico, Romano, Gaetano, Lucchi, Marco, Dini, Paolo, Ambrogi, Marcello C., and Mussi, Alfredo
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MEDICAL robotics ,LUNG cancer ,SURGICAL robots ,SQUAMOUS cell carcinoma ,CARCINOID - Abstract
OBJECTIVES The aim of this study was to analyse the results of robotic lobectomy for lung cancer. The evolution of technique and technology was evaluated. METHODS During the period 2004–12, all patients who underwent robotic lobectomy for clinical early-stage lung cancer were retrospectively reviewed. The patients were divided into two groups. Group 1 included 69 patients operated by the first generation of surgical robotic system. Group 2 included 160 patients treated with the latest generation of surgical robotic system. Age, gender, comorbidities, operative time, docking time, conversion rate, morbidity, mortality and length of postoperative stay were compared in both groups. RESULTS The two groups were homogeneous in terms of age, gender and comorbidities. Histopathological analysis showed 41 and 107 adenocarcinomas, 27 and 37 squamous cell carcinomas, 1 and 7 large cell carcinomas, in Groups 1 and 2, respectively, and 5 sarcomatoid carcinomas and 4 carcinoids in Group 2. The pathological stage for Group 1 was Stage I (48 cases), Stage II (17 cases) and Stage III (4 cases). For Group 2, Stage I was found in 115 cases, Stage II in 30 cases and Stage III in 15 cases. The mean operative time was 237 (standard deviation (SD) + 66.9) and 172 (SD ± 39.6) min for Groups 1 and 2 (P = 0.002), respectively. The conversion rates were, respectively, 10.1 and 5.6% (P = 0.21), mortality rates 1.4 and 0% (P = 0.30) and morbidity rates 22 and 15% (P = 0.12). The mean length of postoperative stay was 4.4 (SD ± 3.1) and 3.8 days (SD ± 2.2) (P = 0.26), respectively. CONCLUSIONS This study suggests a positive trend in the outcomes for patients who underwent the upgraded robotic system surgery compared with those treated by the standard system. [ABSTRACT FROM AUTHOR]
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- 2014
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154. A Commentary on iPS Cells: Potential Applications in Autologous Transplantation, Study of Illnesses and Drug Screening.
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Romano, Gaetano, Morales, Fátima, Marino, Ignazio R., and Giordano, Antonio
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INDUCED pluripotent stem cells , *AUTOTRANSPLANTATION , *DRUG use testing , *STEM cell research , *PLANT epigenetics , *PLURIPOTENT stem cells - Abstract
Undoubtedly, the focus of the field of stem cell research is predominantly aimed at the artificial reprogramming of human somatic cells for the production of induced pluripotent stem (iPS) cells. This relatively new technology may circumvent the ethical issues of using human embryonic stem (hES) cells for the potential applications in cell replacement therapy. Besides such ethical issues, iPS cell technology offers the advantage of obtaining patient-derived tissues and/or cells, which may be utilized for autologous transplantation and tissue regeneration, investigation of a variety of human illnesses and for the screening of new drugs. The field of stem cell research has placed a major emphasis in understanding the genetic and epigenetic codes for pluripotency, in order to control and optimize autologous transplantation techniques and avoid teratoma formation. J. Cell. Physiol. 229: 148-152, 2014. © 2013 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
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- 2014
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155. Regulatory functions of Cdk9 and of cyclin T1 in HIV Tat transactivation pathway gene expression
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Romano, Gaetano, primary, Kasten, Margaret, additional, De Falco, Giulia, additional, Micheli, Pietro, additional, Khalili, Kamel, additional, and Giordano, Antonio, additional
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- 1999
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156. Multiple Signaling Pathways of the Insulin-Like Growth Factor 1 Receptor in Protection from Apoptosis
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Peruzzi, Francesca, primary, Prisco, Marco, additional, Dews, Michael, additional, Salomoni, Paolo, additional, Grassilli, Emanuela, additional, Romano, Gaetano, additional, Calabretta, Bruno, additional, and Baserga, Renato, additional
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- 1999
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157. Gene Transfer Technology in Therapy: Current Applications and Future Goals
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Romano, Gaetano, primary, Pacilio, Carmen, additional, and Giordano, Antonio, additional
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- 1999
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158. Growth and Differentiation Signals by the Insulin-like Growth Factor 1 Receptor in Hemopoietic Cells Are Mediated through Different Pathways
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Valentinis, Barbara, primary, Romano, Gaetano, additional, Peruzzi, Francesca, additional, Morrione, Andrea, additional, Prisco, Marco, additional, Soddu, Silvia, additional, Cristofanelli, Barbara, additional, Sacchi, Ada, additional, and Baserga, Renato, additional
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- 1999
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159. Konkordanz und Kalter Krieg. Analyse von Medienereignissen in der Schweiz der Zwischen: Und Nachkriegszeit
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Sick, Klaus-Peter, primary, Schmidt-Gernig, Alexander, additional, Imhof, Kurt, additional, Kleger, Heinz, additional, and Romano, Gaetano, additional
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- 1999
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160. Dissociation between resistance to apoptosis and the transformed phenotype in IGF-I receptor signaling
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Romano, Gaetano, primary, Prisco, Marco, additional, Zanocco-Marani, Tommaso, additional, Peruzzi, Francesca, additional, Valentinis, Barbara, additional, and Baserga, Renato, additional
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- 1999
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161. Lernen von Aussen? Oder: Die Betrachtung des Irrationalen als Voraussetzung für Vernunft. Programmatische Mutationen in der Krise der 30er Jahre
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Imhof, Kurt, Kleger, Heinz, Romano, Gaetano, Imhof, K ( Kurt ), Kleger, H ( Heinz ), Romano, G ( Gaetano ), Imhof, Kurt, Kleger, Heinz, Romano, Gaetano, Imhof, K ( Kurt ), Kleger, H ( Heinz ), and Romano, G ( Gaetano )
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- 1993
162. Vermessene Öffentlichkeit – vermessene Forschung? Vorstellung eines Projekts
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Imhof, Kurt, Kleger, Heinz, Romano, Gaetano, Imhof, K ( Kurt ), Kleger, H ( Heinz ), Romano, G ( Gaetano ), Imhof, Kurt, Kleger, Heinz, Romano, Gaetano, Imhof, K ( Kurt ), Kleger, H ( Heinz ), and Romano, G ( Gaetano )
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- 1993
163. Gene Transfer Technology in Therapy: Current Applications and Future Goals
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Romano, Gaetano, primary, Pacilio, Carmen, additional, and Giordano, Antonio, additional
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- 1998
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164. Mythos und Moderne. Zur Fragilität der posttraditionalen Gesellschaft
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Bornschier, Volker, Eisner, Manuel, Imhof, Kurt, Romano, Gaetano, Suter, Christian, Bornschier, V ( Volker ), Eisner, M ( Manuel ), Imhof, K ( Kurt ), Romano, G ( Gaetano ), Suter, C ( Christian ), Bornschier, Volker, Eisner, Manuel, Imhof, Kurt, Romano, Gaetano, Suter, Christian, Bornschier, V ( Volker ), Eisner, M ( Manuel ), Imhof, K ( Kurt ), Romano, G ( Gaetano ), and Suter, C ( Christian )
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- 1990
165. Differential Effects on HIV-1 Gene Regulation by EBV in T Lymphocytic and Promonocytic Cells Transduced to Express Recombinant Human CR2 (CD21)
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Romano, Gaetano, primary, Guan, Mingxu, additional, Long, Walter K., additional, and Henderson, Earl E., additional
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- 1997
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166. Cell Cycle Control and Dysregulation Protocols : Cyclins, Cyclin-dependent Kinases, and Other Factors
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Giordano, Antonio, Romano, Gaetano, Giordano, Antonio, and Romano, Gaetano
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- Phosphotransferases, Transferases, Medical laboratory technology, Histology--Technique, Diagnosis, Enzymes, Cyclin-dependent kinases, Fluorescent antibody technique, DNA, Gene expression, Physical sciences, Biology, Immunohistochemistry, Cyclins--Laboratory manuals, Cell cycle--Laboratory manuals, Cyclin-dependent kinases--Laboratory manuals, Immunocytochemistry, Life sciences, Protein kinases, Immunodiagnosis, Nucleic acids, Proteins
- Abstract
The dysregulation of the normal cell cycle underlies an enormous number of pathological conditions, including the neurodegenerative disorders, all cancers, and diabetes. In Cell Cycle Control and Dysregulation Protocols: Cyclins, Cyclin-Dependent Kinases, and Other Factors, expert laboratorians detail emerging methodologies for studying the cell cycle, its kinases, and kinase inhibitors. The authors focus on issues of gene expression in vivo and in vitro, the analysis of cyclin-dependent kinase inhibitors, protein degradation mediated by the proteosome, the analysis of the transformed cell phenotype, and innovative techniques to detect apoptosis. Many of the protocols are new, such as electron microsocopy to detect apoptosis and proteosome-mediated degradation, whereas others study the interactions between protein-protein, protein-DNA, and protein-RNA. The protocols follow the successful Methods in Molecular Biology™ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. State-of-the-art and highly practical, Cell Cycle Control and Dysregulation Protocols: Cyclins, Cyclin-Dependent Kinases, and Other Factors offers pathbreaking researchers powerful tools for probing the cell cycle regulation across a wide variety of pathologies.
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- 2004
167. A transient three-plasmid expression system for the production of high titer retroviral vectors
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Soneoka, Yuko, primary, Cannon, Paula M., additional, Ramsdale, Emma E., additional, Griffiths, Joanne C., additional, Romano, Gaetano, additional, Kingsman, Susan M., additional, and Kingsman, Alan J., additional
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- 1995
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168. Expandable intramedullary nailing and platelet rich plasma to treat long bone non-unions.
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Olimpio Galasso, Bruno Iannò, Galasso, Olimpio, Mariconda, Massimo, Romano, Gaetano, Capuano, Nicola, Romano, Luigi, Iannò, Bruno, and Milano, Carlo
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INTRAMEDULLARY fracture fixation ,BLOOD plasma ,BLOOD platelets ,PSEUDARTHROSIS ,ORTHOPEDIC surgery ,BONE diseases - Abstract
Background: Roentgenographic and functional outcomes of expandable self locking intramedullary nailing and platelet rich plasma (PRP) gel in the treatment of long bone non-unions are reported.Materials and Methods: Twenty-two patients suffering from atrophic diaphyseal long bone non-unions were enrolled in the study. Patients were treated with removal of pre-existing hardware, decortication of non-union fragments, and fixation of pseudoarthrosis with expandable intramedullary nailing (Fixion, Disc'O Tech, Tel Aviv, Israel). At surgery, PRP was placed in the pseudoarthrosis rim.Results: The thirteen-month follow-up showed 91% (20/22 patients) of patients attaining bony union. The average time to union was 21.5 weeks. No infection, neurovascular complication, rotational malalignment, or limb shortening >4 mm were observed. The healing rate of non-unions was comparable to that observed in previous studies but with a lower complication frequency.Conclusions: The combined use of self locking intramedullary nailing and PRP in the management of atrophic diaphyseal long bone non-unions seems to produce comparable results with less complications than previously reported. Further data are warranted to investigate the single contribution of PRP gel and Fixion nail. [ABSTRACT FROM AUTHOR]- Published
- 2008
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169. «Die Gesellschaft der Gesellschaft»: Über Rezeptionsprobleme der Kommunikationswissenschaft.
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Romano, Gaetano
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- 2007
170. Tyrosine hydroxylase gene regulation in human neuronal progenitor cells does not depend on Nurr1 as in the murine and rat systems<FNR></FNR><FN>Hao Jin and Gaetano Romano equally contributed to this work. </FN>.
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Hao Jin, Romano, Gaetano, Marshall, Cheryl, Donaldson, Angela E., Suon, Sokreine, and Iacovitti, Lorraine
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TYROSINE , *GENETIC regulation , *GENE expression , *GENE silencing , *HOMOLOGY (Biology) , *ANIMAL models in research - Abstract
A previous study on the human tyrosine hydroxylase (TH) promoter revealed remarkable differences in the mechanism of TH gene regulation between the human and murine models. Indeed, a low degree of homology was observed in the sequence of TH promoters among human, mouse, and rat systems. Only five short conserved regions (CRs) could be identified among the three species. A human TH minimal promoter was engineered and assembled into a self-inactivating lentiviral vector system. This human TH minimal promoter contained the five CRs plus the first -194 bp from the transcription start of the human TH promoter and the first 35 bp of the untranslated messenger RNA leader of the human TH gene. A significant degree of specificity for this human TH minimal promoter was observed only for human neuronal progenitor cells (hNPCs), but not for TH-positive differentiated mouse primary striatal and substantia nigra cells, indicating a significant difference in TH gene regulation between the human and mouse systems. Not only is the degree of homology between the human and mouse promoters in the range of only 46%, but also those few elements that share a high degree of homology display totally different functions in human and mouse brain-derived cells. In the rodent system, NR4A2 (Nurr1) is required for the transactivation of TH minimal promoters. Intriguingly, neither the dimeric nor the heterodimeric binding sites for Nurr1 are present in the 13 kb DNA sequence that contains the human TH promoter. Instead, the CRs termed one and four of the human TH promoter encode only for a half palindromic binding site sequence for Nurr1, which failed to bind Nurr1 in an in vitro electrophoretic mobility shift assay (EMSA). Additionally, of the three monomeric NGFI-B response element (NBRE) core sites (AGGTCA) and two NBRE-related sites present in the human TH promoter, only one core and two NBRE-related sites formed protein binding complexes. Interestingly, there was no increase of protein binding complex formation upon TH induction and in no case could antibodies supershift Nurr1 from the complex. These findings, taken together, demonstrate that NBRE-related binding sites for Nurr1 do not play a direct role in mediating an interaction between Nurr1 and the human TH promoter. Likewise, immunohistochemical and Western blot analysis have also confirmed that both endogenous and exogenous Nurr1 expression does not positively correlate with TH gene expression in hNPCs, in contrast to the mouse model. In addition, real-time PCR analysis revealed that the downregulation of human Nurr1 gene expression mediated by silencing RNA molecules did not affect human TH gene expression in differentiated hNPCs. A better understanding of human TH gene regulation may have important implications both for the development of novel therapeutic approaches and the study of the pathogenesis of a variety of neurological illnesses, including Parkinson's disease, bipolar disorder, and schizophrenia. J. Cell. Physiol. 207: 49–57, 2006. © 2005 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
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- 2006
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171. Retroviral and Lentiviral Vector Titration by the Analysis of the Activity of Viral Reverse Transcriptase.
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Walker, John M., Tonini, Tiziana, Claudio, Pier Paolo, Giordano, Antonio, and Romano, Gaetano
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The assessment of the viral titer is an important step in optimizing and reproducing working conditions for the gene transduction for various mammalian cell types. The assessment of the viral titer is an important parameter to determine the maximum number of target cells that can be infected for a given volume of viral stock (1). [ABSTRACT FROM AUTHOR]
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- 2004
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172. SOZIALER WANDEL UND RECHTSPRODUKTION.
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Imhof, Kurt and Romano, Gaetano
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SOCIAL change ,SOCIAL history ,SOCIAL processes ,SOCIOECONOMICS ,SOCIOECONOMIC factors - Abstract
Copyright of Swiss Journal of Sociology / Schweizerische Zeitschrift für Soziologie is the property of Sciendo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 1988
173. Preliminary clinical and radiographic results with the Fixion intramedullary nail: an inflatable self-locking system for long bone fractures
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Lepore, Stefano, Capuano, Nicola, Lepore, Luciano, and Romano, Gaetano
- Abstract
Abstract: We present a new inflatable self-locking intramedullary nailing system for the treatment of long bone fractures. The features of this system and the advantages of the technique include: fixation along the entire length of the nail, lack of proximal or distal interlocking screws, optional reaming, reduced exposure of the surgeon to X-ray and reduced operating room time. First preliminary clinical and radiographic results are reported. Out of 41 patients who received implants for closed fractures, 29 were available for follow-up. We observed fracture consolidation in all 29 cases (100%), with absence of nonunions, infections or rotational malalignments. Only in 2 (6.9%) cases were complication reported, consisting in the opening of the fracture after inflation of the nail. Good stability of the nail, however, assured a complete callus formation. We conclude that the use of this intramedullary nail is an innovative, effective, simple and minimally invasive treatment for long bone shaft fractures.
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- 2000
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174. Novel methods for efficient changepoint detection
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Romano, Gaetano
- Abstract
This thesis introduces several novel computationally efficient methods for offline and online changepoint detection. The first part of the thesis considers the challenge of detecting abrupt changes in scenarios where there is some autocorrelated noise or where the mean fluctuates locally between the changes. In such situations, existing implementations can lead to substantial overestimation of the number of changes. In response to this challenge, we introduce DeCAFS, an efficient dynamic programming algorithm to deal with such scenarios. DeCAFS models local fluctuations as a random walk process and autocorrelated noise as an AR(1) process. Through theory and empirical studies we demonstrate that this approach has greater power at detecting abrupt changes than existing approaches. The second part of the thesis considers a practical, computational challenge that can arise with online changepoint detection within the real-time domain. We introduce a new procedure, called FOCuS, a fast online changepoint detection algorithm based on the simple Page-CUSUM sequential likelihood ratio test. FOCuS enables the online changepoint detection problem to be solved sequentially in time, through an efficient dynamic programming recursion. In particular, we establish that FOCuS outperforms current state-of-the-art algorithms both in terms of efficiency and statistical power, and can be readily extended to more general scenarios. The final part of the thesis extends ideas from the nonparametric changepoint detection literature to the online setting. Specifically, a novel algorithm, NUNC, is introduced to perform an online detection for changes in the distribution of real-time data. We explore the properties of two variants of this algorithm using both simulated and real data examples.
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- 2021
175. Einwanderungspopulationen: soziodemographische Daten als Indikatoren im internationalen und interethnischen Kulturvergleich
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Hoffmann-Nowotny, Hans-Joachim, Imhof, Kurt, Romano, Gaetano, Haller, Max, Hoffmann-Nowotny, Hans-Joachim, Zapf, Wolfgang, and Deutsche Gesellschaft für Soziologie (DGS)
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ethnische Gruppe ,amtliche Statistik ,migration ,Sociology & anthropology ,ethnic group ,sozialer Wandel ,basic research ,Datengewinnung ,wissenschaftstheoretisch ,Cultural Sociology, Sociology of Art, Sociology of Literature ,assimilation ,minority ,epistemological ,social change ,social integration ,Daten ,Europe ,data capture ,official statistics ,development of methods ,data ,Soziologie, Anthropologie ,Methodenentwicklung ,Minderheit ,soziale Integration ,ddc:301 ,Europa ,Kultursoziologie, Kunstsoziologie, Literatursoziologie ,Grundlagenforschung - Abstract
Dieser Beitrag resultiert aus methodologischen Problemen, die im Rahmen eines laufenden Forschungsprojekts auftraten. Ziel dieser Studie ist, die mutmaßlich differenzielle Integration und Assimilation (als abhängige Variable) eingewanderter Minderheiten verschiedener Ethnien in sieben europäischen Ländern zunächst deskriptiv zu erfassen, dies mittels demographischer Daten der in die Untersuchung einbezogenen Länder zu tun, und über einen theoriengeleiteten internationalen und interethnischen Vergleich zu Modellen zu kommen, welche die vermuteten Unterschiede von Integrations- und Assimilationsprozessen erklären können. Es werden die erheblichen Probleme in der Phase der Datenerfassung dargestellt, die vor allem die Schwierigkeit betreffen, einen vergleichbaren Datensatz zu erstellen. Die Probleme, die sich beim Vergleich nationaler Datensätze stellen, verweisen auf die Einbettung von Migrationsbewegungen in zwei übergreifende Zusammenhänge: Migrationsbewegungen vollziehen sich vor dem Hintergrund eines globalen Weltsystems und sind zugleich eingebettet in Prozesse sozialen Wandels. (GF)
- Published
- 1988
176. Retroviral and lentiviral vector titration by the analysis of the activity of viral reverse transcriptase
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Tonini, Tiziana, Claudio, Pier Paolo, Antonio Giordano, and Romano, Gaetano
177. Detecting Abrupt Changes in the Presence of Local Fluctuations and Autocorrelated Noise
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Romano, Gaetano, Rigaill, Guillem, Runge, Vincent, and Fearnhead, Paul
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13. Climate action - Abstract
While there are a plethora of algorithms for detecting changes in mean in univariate time-series, almost all struggle in real applications where there is autocorrelated noise or where the mean fluctuates locally between the abrupt changes that one wishes to detect. In these cases, default implementations, which are often based on assumptions of a constant mean between changes and independent noise, can lead to substantial over-estimation of the number of changes. We propose a principled approach to detect such abrupt changes that models local fluctuations as a random walk process and autocorrelated noise via an AR(1) process. We then estimate the number and location of changepoints by minimizing a penalized cost based on this model. We develop a novel and efficient dynamic programming algorithm, DeCAFS, that can solve this minimization problem; despite the additional challenge of dependence across segments, due to the autocorrelated noise, which makes existing algorithms inapplicable. Theory and empirical results show that our approach has greater power at detecting abrupt changes than existing approaches. We apply our method to measuring gene expression levels in bacteria. Supplementary materials for this article are available online.
178. Mutagenic and DNA repair activity in traffic policemen: a case-crossover study.
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Ledda, Caterina, Loreto, Carla, Bracci, Massimo, Lombardo, Claudia, Romano, Gaetano, Cinà, Diana, Mucci, Nicola, Castorina, Sergio, and Rapisarda, Venerando
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AUTOMOBILE emissions ,CROSSOVER trials ,LIQUID chromatography ,MASS spectrometry ,METROPOLITAN areas ,MUTAGENICITY testing ,POLICE ,POLYCYCLIC aromatic hydrocarbons ,SALMONELLA ,SHIFT systems ,TRAFFIC accidents ,URINALYSIS ,OCCUPATIONAL hazards ,ENVIRONMENTAL exposure - Abstract
Background: Emissions from vehicles are composed of heterogeneous mixtures of hazardous substances; several pollutants such as Polycyclic Aromatic Hydrocarbons (PAHs) are amongst the most dangerous substances detected in urban monitoring. A cohort of traffic policemen usually occupationally exposed to PAHs present in the urban environment were examined in order to assess the mutagenicity and DNA capacity repair. Methods: Seventy-two urban traffic policemen working in Catania’s metropolitan area were enrolled in the study. Two spot urine samples were collected from each subject during the whole working cycle as follows: sample 1 (S1), pre-shift on day 1; sample 2 (S2) post-shift on day 6. 1-hydroxypyrene (1-OHP) was measured to serve as an indirect exposure indicator. Urinary mutagenic activity was assessed through the plate incorporation pre-incubation technique with S9, using YG1024 Salmonella typhimurium strain over-sensitive to PAH metabolite. Concentrations of urinary 8-oxodG were measured using liquid chromatography tandem mass spectrometry. Results: As regards the exposure to PAHs, results highlighted a statistically significant difference (p < 0.001) between pre-shift on day 1 and post-shift on day 6 levels. Mutagenic activity was detected in 38 (66%) workers on S1 and in 47 (81%) on S2. Also 8-oxodG analysis showed a statistically significant difference between S1 and S2 sampling. Conclusions: This study demonstrated that occupational exposure to pollutants from traffic emission, assessed via 1-OHP measurements in urine, may lead to DNA repair and mutagenic activity, in line with other studies. [ABSTRACT FROM AUTHOR]
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- 2018
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179. Editorial.
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Eppler, Martin J., Rigotti, Eddo, Romano, Gaetano, and Viallon, Philippe
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PREFACES & forewords ,MASS media & culture - Abstract
A preface for the November 2008 issue of the periodical "Studies in Communication Sciences" is presented.
- Published
- 2008
180. Editorial.
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Eppler, Martin J., Rigotti, Eddo, Romano, Gaetano, and Viallon, Philippe
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PREFACES & forewords ,VISUAL communication - Abstract
The article discusses various papers published within the November 2007 issue of "Studies in Communication Sciences"
- Published
- 2007
181. The Role of Lymphadenectomy in Early-Stage NSCLC.
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Manfredini, Beatrice, Zirafa, Carmelina Cristina, Filosso, Pier Luigi, Stefani, Alessandro, Romano, Gaetano, Davini, Federico, and Melfi, Franca
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LUNG cancer , *ADJUVANT chemotherapy , *LYMPHADENECTOMY , *EARLY detection of cancer , *METASTASIS , *CANCER relapse , *PROGRESSION-free survival - Abstract
Simple Summary: The extension of lymph node dissection in the treatment of early-stage non-small cell lung cancer (NSCLC) is currently a controversial argument in the scientific community. There are few studies that look at the role of lymphadenectomy in exclusively stage I NSCLC, and in them the lymph node evaluation method is not standardized, avoiding the comparison between different studies. The future perspectives on this issue will need to focus on the necessity of carrying out more precise investigations into the propagation of micrometastases in lung cancer and the application of the latest available techniques for their detection, resulting in a reduction in both local and distant recurrence. Lung cancer remains the leading cause of cancer-related death worldwide. The involvement of lymph nodes by the tumor has a strong impact on survival of patients. For this reason, lymphadenectomy plays a crucial role in the staging and prognosis of NSCLC, to define the most appropriate therapeutic strategies concerning the stage of the disease. To date, the benefit, in terms of survival, of the different extents of lymphadenectomy remains controversial in the scientific community. It is recognized that metastatic involvement of mediastinal lymph nodes in lung cancer is one of the most significant prognostic factors, in terms of survival, and it is therefore mandatory to identify patients with lymph node metastases who may benefit from adjuvant therapies, to prevent distant disease and local recurrences. The purpose of this review is to evaluate the role of lymphadenectomy in early-stage NSCLC in terms of efficacy and accuracy, comparing systematic, sampling, and lobe-specific lymph node dissection and analyzing the existing critical issue, through a search of the most relevant articles published in the last decades. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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182. Machine Learning and Regression Analysis to Model the Length of Hospital Stay in Patients with Femur Fracture.
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Ricciardi, Carlo, Ponsiglione, Alfonso Maria, Scala, Arianna, Borrelli, Anna, Misasi, Mario, Romano, Gaetano, Russo, Giuseppe, Triassi, Maria, and Improta, Giovanni
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FEMORAL fractures , *LENGTH of stay in hospitals , *MACHINE learning , *REGRESSION analysis , *RADIAL basis functions , *FEMUR , *FEMUR neck - Abstract
Fractures of the femur are a frequent problem in elderly people, and it has been demonstrated that treating them with a diagnostic–therapeutic–assistance path within 48 h of admission to the hospital reduces complications and shortens the length of the hospital stay (LOS). In this paper, the preoperative data of 1082 patients were used to further extend the previous research and to generate several models that are capable of predicting the overall LOS: First, the LOS, measured in days, was predicted through a regression analysis; then, it was grouped by weeks and was predicted with a classification analysis. The KNIME analytics platform was applied to divide the dataset for a hold-out cross-validation, perform a multiple linear regression and implement machine learning algorithms. The best coefficient of determination (R2) was achieved by the support vector machine (R2 = 0.617), while the mean absolute error was similar for all the algorithms, ranging between 2.00 and 2.11 days. With regard to the classification analysis, all the algorithms surpassed 80% accuracy, and the most accurate algorithm was the radial basis function network, at 83.5%. The use of these techniques could be a valuable support tool for doctors to better manage orthopaedic departments and all their resources, which would reduce both waste and costs in the context of healthcare. [ABSTRACT FROM AUTHOR]
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- 2022
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183. Changes in microbial utilization and fate of soil carbon following the addition of different fractions of anaerobic digestate to soils.
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Cattin, Marta, Semple, Kirk T., Stutter, Marc, Romano, Gaetano, Lag‐Brotons, Alfonso J., Parry, Chris, and Surridge, Ben W. J.
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GRASSLAND soils , *CARBON in soils , *DISSOLVED organic matter , *SOILS , *ANAEROBIC digestion , *CARBON dioxide - Abstract
Applying digestate, the residue from anaerobic digestion, to soil as a replacement for inorganic fertiliser is of growing interest in agriculture. However, the impacts of different fractions of digestate on the soil carbon (C) cycle remain unclear and provide the focus for the research reported here. We examined the effects of applying whole digestate (WD) and solid digestate (SD) on carbon dioxide (CO2C) efflux, the concentrations of dissolved organic carbon (DOC), microbial biomass C (Cmicro) and phospholipid fatty acids, alongside carbon use efficiency (CUE). A 21‐day laboratory microcosm incubation was used to investigate the impacts of digestate when applied to two grassland soils of high versus low initial nutrient content. Application rates for SD and WD were based on recommended nitrogen (N) inputs to grassland soils for these organic materials. Compared to control treatments, cumulative CO2C efflux and the concentration of DOC increased significantly after WD and SD application, although only within the low nutrient soil. Both Cmicro and the fungal‐to‐bacterial ratio increased significantly following SD application, regardless of the initial soil nutrient content. These observations are likely to reflect the larger input of C, alongside the dominance of more strongly lignified compounds, associated with SD compared to WD to achieve a constant N application rate. Our results also indicate that the two digestate fractions generated significantly different CUE. The application of SD led to increases in Cmicro and positive values of CUE, whereas decreases in Cmicro and negative values of CUE were observed following WD application. These findings emphasize the need to carefully plan the management of digestate in agricultural production systems, to minimize negative impacts on C storage within soils whilst maximizing the agronomic value derived from digestate. Highlights: Past research has not fully elucidated the impacts of digestate fractions on the soil C cycle.Soil nutrient status + digestate fraction shown to impact microbial community and CO2C efflux.Solid digestate fraction has positive impacts on microbial biomass and carbon use efficiency. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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184. The role of the insulin receptor substrate-1 in the differentiation of rat hippocampal neuronal cells.
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Morrione, Andrea, Navarro, Magali, Romano, Gaetano, Dews, Michael, Reiss, Krzysztof, Valentinis, Barbara, Belletti, Barbara, and Baserga, Renato
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SOMATOMEDIN , *HIPPOCAMPUS (Brain) , *PHOSPHOINOSITIDES , *MYOBLASTS - Abstract
H19-7/IGF-IR cells are rat hippocampal cells expressing a human IGF-I receptor, which differentiate to a neuronal phenotype when stimulated by IGF-I at 39°C. H19-7/IGF-IR cells have low levels of expression of insulin receptor substrate-l (IRS-1), a major substrate of the IGF-IR. IGF-I induces serine-phosphorylation and down-regulation of the endogenous IRS-1 upon differentiation of H19-7/IGF-IR cells. The profound influence of IRS-1 on differentiation of H19-7/IGF-IR cells was confirmed by transfecting these cells with a plasmid expressing mouse IRS-1. Over-expression of wild type IRS-1 in H19-7/IGF-IR cells abolishes IGF-I-induced differentiation at 39°C. A mutant of IRS-1 lacking the PTB domain loses the ability to inhibit the differentiation program. H19-7/IGF-IR/IRS-1 cells at 39°C show a stronger and prolonged activation of Akt, when compared to H19-7/IGF-IR cells. The role of Akt in the inhibition of the differentiation program was confirmed by using the inhibitor of Class I PI3 kinases LY29400, which restores IGF-I-induced differentiation of H19-7/IGF-IR/IRS-1 cells. H19-7/IGF-IR/IRS-1 cells show a strong reduction in MAP kinases signaling, which is related to the superactivation of Akt. This was confirmed by expressing in H19-7/IGF-IR cells a constitutively active Akt, which inhibited MAP kinases activation in these cells. These experiments confirm the importance of MAPK in the mechanism of IGF-I-mediated differentiation of H19-7/IGF-IR cells Oncogene (2001) 20, 4842–4852. [ABSTRACT FROM AUTHOR]
- Published
- 2001
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185. Mechanisms of regulation of cell adhesion and motility by insulin receptor substrate-1 in prostate cancer cells.
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Reiss, Krzysztof, Wang, Jin-Ying, Romano, Gaetano, Tu, Xiao, Peruzzi, Francesca, and Baserga, Renato
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- *
PROSTATE cancer , *CANCER cells , *TUMOR suppressor genes , *CELL adhesion - Abstract
LNCaP cells are human prostatic cancer cells that have a frame-shift mutation of the tumor suppressor gene PTEN and do not express the insulin receptor substrate-1 (IRS-1), a major substrate of the type 1 insulin-like growth factor receptor (IGF-IR). Ectopic expression of IRS-1 in LNCaP cells increases cell adhesion and decreases cell motility by an IGF-I-independent mechanism. We show now that these effects of IRS-1 are accompanied by serine phosphorylation of IRS-1 and are inhibited by inhibitors of phosphatidylinositol 3-kinase (PI3K). We have confirmed the requirement for PI3K activity and serine phosphorylation by the use of IRS-1 mutants, expressed in LNCaP cells. Serine phosphorylation inhibits IGF-I-induced tyrosyl phosphorylation of IRS-1, which is restored by the expression of wild-type PTEN or by inhibition of PI3K activity. Finally, IRS-1 in LNCaP cells co-immunoprecipitates with integrin α 5 β 1, and the association is again IGF-I-independent. We conclude that in LNCaP cells, IRS-1 is serine phosphorylated by PI3K, generating effects that are different, and even opposite, from those generated by IGF-I. Oncogene (2001) 20, 490–500. [ABSTRACT FROM AUTHOR]
- Published
- 2001
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186. IGF-I receptor signaling in a prostatic cancer cell line with a PTEN mutation.
- Author
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Reiss, Krzysztof, Wang, Jin-Ying, Romano, Gaetano, Furnari, Frank B, Cavenee, Webster K, Morrione, Andrea, Tu, Xiao, and Baserga, Renato
- Subjects
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CANCER cells , *SOMATOMEDIN , *PROSTATE cancer - Abstract
LNCaP prostatic cancer cells are characterized by having a PTEN mutation, low levels of type 1 insulin-like growth factor receptor (IGF-IR) and no IRS-1, one of the major substrates of the IGF-IR. The absence of IRS-1, an activator of PI3-kinase, is compensated in these cells by the mutation in PTEN, an inhibitor of PI3-kinase. However, IGF-IR signaling in the absence of IRS-1 can cause cell differentiation and growth arrest. We hypothesized that these three characteristics may not be unrelated, specifically that, together, they may favor the metastatic spread of prostatic cancer cells without decreasing their growth potential. In support of this hypothesis, we report here that: (1) IRS-1 expression increases cell adhesion and decreases cell motility; (2) over-expression of the IGF-IR, in the absence of IRS-1, causes growth arrest and (3) a combination of IGF-IR and IRS-1 restores the transformed phenotype of LNCaP cells. These findings suggest a mechanism by which prostatic cancer cells can achieve metastatic potential without interfering with their growth potential. Oncogene (2000) 19, 2687–2694 [ABSTRACT FROM AUTHOR]
- Published
- 2000
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187. Lung metastasectomy after colorectal cancer: prognostic impact of resection margin on long term survival, a retrospective cohort study.
- Author
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Davini, Federico, Ricciardi, Sara, Zirafa, Carmelina C., Romano, Gaetano, Alì, Greta, Fontanini, Gabriella, and Melfi, Franca M.A.
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COLORECTAL cancer , *COHORT analysis , *LUNGS , *METASTASIS - Abstract
Background: Pulmonary metastasectomy is considered a potentially curative treatment for selected patients with metastatic colorectal cancer (CRC). Several prognostic factors have been analysed, but to date, it is still not well defined which is the optimal resection margin during lung metastasectomy (LM). This study analyses the long-term results and prognostic factors after LM in CRC patients with particular attention to the resection margins. Primary endpoint of this study is to assess the correlation between resection margins and long-term outcomes. Methods: Observational cohort study on all proven cases of CRC lung metastases (2000–2016) resected with curative intent in a single centre. Results: The series included 210 consecutive patients (M/F 133/77) with a mean age of 65.4 (± 9.96) years, 75% (159/210) of them with a solitary metastasis. Mean size of metastasis was 2.57 cm (± 1.45). One hundred sixty-eight patients underwent wedge resections (80%) and lymphadenectomy was carried out in 90 cases (42.9%). With a mean follow-up of 56 months (range 5–192), we observed a 1-, 3- and 5-year overall survival (OS) of 95%, 74% and 54%, respectively. The patients were divided into three groups according to the resection margin distance from the tumour: (a) ≥ 2 cm (145 cases); (b) < 2, ≥ 1 cm (37 cases); and (c) < 1 cm (12 cases). The OS was significantly different between the three groups (p = 0,020); univariate and multivariate analyses showed that a narrow resection margin was an independent prognostic factor of worse survival (p = 0.006 and HR 3.4 p = 0.009). Conclusions: Long-term survival of patients after LM is strongly associated with a greater distance between the lesion and the resection margin. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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188. Nodal upstaging evaluation in NSCLC patients treated by robotic lobectomy.
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Zirafa, Carmelina, Aprile, Vittorio, Ricciardi, Sara, Romano, Gaetano, Davini, Federico, Cavaliere, Ilenia, Alì, Greta, Fontanini, Gabriella, and Melfi, Franca
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NON-small-cell lung carcinoma , *LOBECTOMY (Lung surgery) , *SURGICAL robots , *VIDEO-assisted thoracic surgery , *LYMPH nodes , *LYMPHADENECTOMY , *THORACIC surgery , *LUNG cancer , *LUNG tumors , *PNEUMONECTOMY , *TUMOR classification , *RETROSPECTIVE studies - Abstract
Background: Open pulmonary resection is considered the gold standard treatment of early-stage non-small cell lung cancer (NSCLC). However, in the last decades, the use of minimal-invasive techniques has given promising results. Survival in lung cancer, after surgery, depends on the number of pathological nodes (pN), thus lymph nodal upstaging can be considered a surrogate for surgical quality of the procedure. Several studies have demonstrated a lower rate of upstaging in video-assisted thoracic surgery than in open surgery, suggesting an approach-related difference in lymphadenectomy. Features of robotic technique could consent a lymph nodal dissection similar to open surgery. The aim of the study is to compare nodal upstaging between thoracotomy and robotic approaches to evaluate the oncologic radicality.Methods: Between January 2013 and December 2016, 212 consecutive cN0 NSCLC patients underwent lobectomy and lymphadenectomy (N1 + N2 stations) by either thoracotomy (Open Group) or robotic surgery (Robotic Group).Results: Lobectomy and lymphadenectomy were performed in 106 cN0-cN1 NSCLC patients by robotic surgery and in 106 cN0-cN1 NSCLC patients by open surgery. A mean of 14.42 ± 6.99 lymph nodes was removed in the Robotic Group (RG) and a mean of 14.32 ± 7.34 nodes in the Open Group (OG). Nodal upstaging was observed in 22 (20.75%) RG patients and in 19 OG (17.92%) patients.Conclusions: Robotic lobectomy for clinical N0-N1 NSCLC appears to be equivalent to thoracotomy in terms of efficacy of lymph node dissection and nodal upstaging. Given that the nodal upstaging is a surrogate of quality of surgery, we can consider robotic lobectomy an appropriate procedure which ensures similar result to the open approach. [ABSTRACT FROM AUTHOR]- Published
- 2019
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189. Thyroid malignant neoplasm-associated biomarkers as targets for oncolytic virotherapy.
- Author
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Mingxu Guan, Yanping Ma, Shah, Sahil Rajesh, and Romano, Gaetano
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- 2016
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190. EuroSCORE II Versus Additive and Logistic EuroSCORE in Patients Undergoing Percutaneous Coronary Intervention.
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Capodanno, Davide, Dipasqua, Fabio, Marcantoni, Carmelita, Ministeri, Margherita, Zanoli, Luca, Rastelli, Stefania, Romano, Gaetano, Sanfilippo, Maria, and Tamburino, Corrado
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CORONARY disease , *RISK assessment , *CALIBRATION , *MORTALITY , *ACCURACY , *PATIENTS - Abstract
The aim of the present study was to externally validate the European System for Cardiac Operative Risk Evaluation (EuroSCORE) II (ESII) in patients undergoing percutaneous coronary intervention (PCI) and to compare its performance with that of its previously released versions, named additive (addES) and logistic EuroSCORE (logES). A total of 537 patients undergoing PCI were analyzed by different measurements of discrimination, calibration, and global accuracy. A significant gradient in all-cause mortality was seen with all the models at 30 days, 1 year, and 5 years, with the exception of the ESII at 30 days. The ESII had the lowest area under the receiver operating characteristic curve at all time points compared with its previous version, being 0.83 (vs 0.90 for both addES and logES) at 30 days, 0.75 (vs 0.82 for both addES and logES) at 1 year, and 0.69 (vs 0.77 for addES and 0.76 for logES) at 5 years. However, the ESII displayed a better calibration than the logES at 30 days, whereas both scores were miscalibrated at 1 and 5 years. The Brier score displayed similar global accuracy between the ESII and logES. In conclusion, the ESII is better calibrated than the logES at 30 days but does not represent a step forward in discrimination and global accuracy compared with its previous versions for predicting early- and long-term mortality of patients undergoing PCI. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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191. The Fixion expandable stem hemiarthroplasty for displaced femoral neck fracture: technical features and pilot study.
- Author
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Folman, Yoram, Ron, Nimrod, Shabat, Shay, Romano, Gaetano, and Galasso, Olimpio
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- *
ARTHROPLASTY , *JOINT surgery , *FEMUR neck , *BONE fractures , *PATIENTS , *BONE injuries , *SURGERY - Abstract
Management of displaced femoral neck fracture in elderly patients is challenging due to the patient’s high risk profile, poor quality bone stock and muscle weakness. Fifty-one patients with displaced (Garden 3–4) intracapsular femoral neck fractures were treated with a newly designed Fixion expandable stem hemiarthroplasty implant and followed thereafter for a minimum of 6 months. Thirty patients (58.8%) had concomitant diseases graded 3–4 by the ASA scoring system. Two patients (4.8%) incurred deep wound infections that necessitated hardware removal. One case (2.6%) of dislocation was treated by closed reduction. Forty-two patients (82.4%) survived >6 months and cooperated with the study protocol. Mild groin/thigh pain was reported by 11 patients (26.2%). Twenty-six (61.9%) had lost 1–2 out of 4 grades of mobility. Fixion implant may be considered a further step in the evolution of femoral joint hemiarthroplasty. In the short term, it has proven to be as effective as cemented implant and to be user-friendly for the surgeon. It is also anticipated to be feasible whenever revision is required. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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192. Correction to: Lung metastasectomy after colorectal cancer: prognostic impact of resection margin on long term survival, a retrospective cohort study.
- Author
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Davini, Federico, Ricciardi, Sara, Zirafa, Carmelina C., Romano, Gaetano, Alì, Greta, Fontanini, Gabriella, and Melfi, Franca M.A.
- Subjects
- *
COLORECTAL cancer , *COHORT analysis , *LUNGS , *RETROSPECTIVE studies - Abstract
The original version of this article, unfortunately, contained an error. In Fig. 2 - panel d, incorrect image was published and this is now presented correctly in this article. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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193. Activation of the IGF-IR system contributes to malignant growth of human and mouse medulloblastomas.
- Author
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Wang, Jin Ying, Del Valle, Luis, Gordon, Jennifer, Rubini, Michele, Romano, Gaetano, Croul, Sidney, Peruzzi, Francesca, Khalili, Kamel, and Reiss, Krzysztof
- Subjects
- *
SOMATOMEDIN , *MEDULLOBLASTOMA , *CELL proliferation , *TYROSINE , *PHOSPHORYLATION - Abstract
Insulin-like growth factor I receptor (IGF-IR) has been implicated in the normal and malignant growth of many cell types including cells from the central nervous system. In the cerebellar cortex IGF-IR mRNA is found in granular cells and IGF-I stimulation is mitogenic and protects cells from low-potassium-induced apoptosis. Since primitive neuroectodermal tumors/medulloblastomas (PNETs/medulloblastomas) are suspected to originate from the external cerebellar granular layer, it is reasonable to postulate that IGF-IR and/or its signaling molecules may contribute to the transformation of these poorly differentiated cells. To study activation of the IGF-IR system in medulloblastomas, we have utilized an antibody (anti-pY1316) that specifically recognizes the phosphorylated (active) form of the IGF-IR. Medulloblastoma biopsy specimens were positive when examined immunohistochemically with anti-Y1316 antibody. Further analysis of the IGF-IR system was performed in three human (Daoy, TE-671, D283 Med) and four mouse (BsB8, BsB13, Bs-1b, Bs-1c) medulloblastoma cell lines. All the murine cell lines examined express IGF-IR and PI3-kinase at relatively normal levels, and grossly overexpress IRS-1, when compared with normal mouse cerebellum. Within 15 min following IGF-I stimulation both mouse and human cell lines phosphorylate the β subunit of the IGF-IR, IRS-1, Akt, and MAP kinases. They respond with cell proliferation when stimulated solely with IGF-I and are strongly inhibited when challenged with a dominant negative mutant of the IGF-IR (486/STOP), or with antisense oligonucleotides against the IGF-IR mRNA. Oncogene (2001) 20, 3857–3868. [ABSTRACT FROM AUTHOR]
- Published
- 2001
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194. Protest und Selbstbeschreibung
- Author
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Luca Tratschin, Romano, Gaetano, and Heintz, Bettina
- Subjects
political sociology ,communication theory ,soziales Netzwerk ,politics ,political science ,Politikwissenschaft ,conflict ,soziale Bewegung ,interaction ,Sociology & anthropology ,Selbstbeschreibung ,Self-description ,social movements ,motivation ,Allgemeine Soziologie, Makrosoziologie, spezielle Theorien und Schulen, Entwicklung und Geschichte der Soziologie ,Kommunikationstheorie ,General Sociology, Basic Research, General Concepts and History of Sociology, Sociological Theories ,social system ,Political Process, Elections, Political Sociology, Political Culture ,civil society ,Political science ,politische Willensbildung, politische Soziologie, politische Kultur ,self-description ,Protest ,Konflikt ,Interaktion ,world society ,soziales System ,social movement ,protest ,Soziologie, Anthropologie ,ddc:320 ,öffentliche Meinung ,public opinion ,social systems ,social network ,ddc:301 - Abstract
Wie entstehen und reproduzieren sich soziale Bewegungen? Was ist das Verhältnis sozialer Bewegungen zu anderen Typen sozialer Systeme wie z.B. Organisationen, dem Wirtschaftssystem oder der Gesellschaft? Der Autor präsentiert eine kommunikationstheoretische Antwort auf diese Fragen und zeigt, wie soziale Bewegungen durch die kontingente Entdeckung von Gemeinsamkeiten vieler raum-zeitlich verankerter Protestkommunikationen entstehen können. This volume shows how social movements develop through the extremely selective interpretation and recontextualisation of individual protests.
- Published
- 2016
195. Recombinant mitochondrial manganese containing superoxide dismutase protects against Ochratoxin A-induced nephrotoxicity
- Author
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Giovambattista Capasso, Antonella Borrelli, Aldo Mancini, Lorella Severino, Nicola Mirabella, Silvia Boffo, Salvatore Florio, Roberto Ciarcia, Gaetano Romano, Ugo Pagnini, Caterina Squillacioti, Alessia Florio, Antonio Giordano, Sara Damiano, Ciarcia, Roberto, Damiano, Sara, Squillacioti, Caterina, Mirabella, Nicola, Pagnini, Ugo, Florio, Alessia, Severino, Lorella, Capasso, Giovambattista, Borrelli, Antonella, Mancini, Aldo, Boffo, Silvia, Romano, Gaetano, Giordano, Antonio, and Florio, Salvatore
- Subjects
0301 basic medicine ,Male ,Renal function ,Blood Pressure ,Pharmacology ,medicine.disease_cause ,Biochemistry ,rMnSOD ,Nephrotoxicity ,Lipid peroxidation ,Superoxide dismutase ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,medicine ,Animals ,NEPHROTOXICITY ,OCHRATOXIN A ,OXIDATIVE STRESS ,Molecular Biology ,Cell Biology ,chemistry.chemical_classification ,Reactive oxygen species ,Kidney ,Manganese ,biology ,Superoxide Dismutase ,Ochratoxin A ,Ochratoxins ,Recombinant Proteins ,Rats ,Oxidative Stress ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Catalase ,030220 oncology & carcinogenesis ,biology.protein ,Oxidative stre ,Kidney Diseases ,Lipid Peroxidation ,Reactive Oxygen Species ,Oxidative stress ,Glomerular Filtration Rate - Abstract
Ochratoxin A (OTA) is a natural mycotoxin, involved in the development of important human and animal diseases. In this work we have studied the role of oxidative stress in the development of OTA nephrotoxicity and the effect of a new recombinant mitochondrial manganese containing superoxide dismutase (rMnSOD) to prevent kidney damage induced by OTA. Blood pressure, glomerular filtration rate and renal histology were analyzed in control rats and in OTA treated rats. In addition, lipid peroxidation, catalase and superoxide dismutase productions were measured. Our data showed that animals treated with OTA presented hypertension and reduction of glomerular filtration rate (GFR). These effects are most probably related to an increase in the reactive oxygen species (ROS) productions. In fact, we have shown that treatment with rMnSOD restored the levels of blood pressure and GFR simultaneously. Moreover, we have noted that OTA induced alteration on glomerular and tubular degeneration and interstitial infiltrates and that use of rMnSOD combined with OTA prevent this renal histological damage confirming the potential therapeutic role in the treatment of rMnSOD OTA nephrotoxicity. Ochratoxin A (OTA) is a natural mycotoxin, involved in the development of important human and animal diseases. In this work we have studied the role of oxidative stress in the development of OTA nephrotoxicity and the effect of a new recombinant mitochondrial manganese containing superoxide dismutase (rMnSOD) to prevent kidney damage induced by OTA. Blood pressure, glomerular filtration rate and renal histology were analyzed in control rats and in OTA treated rats. In addition, lipid peroxidation, catalase and superoxide dismutase productions were measured. Our data showed that animals treated with OTA presented hypertension and reduction of glomerular filtration rate (GFR). These effects are most probably related to an increase in the reactive oxygen species (ROS) productions. In fact, we have shown that treatment with rMnSOD restored the levels of blood pressure and GFR simultaneously. Moreover, we have noted that OTA induced alteration on glomerular and tubular degeneration and interstitial infiltrates and that use of rMnSOD combined with OTA prevent this renal histological damage confirming the potential therapeutic role in the treatment of rMnSOD OTA nephrotoxicity.
- Published
- 2016
196. Alte und neue Einflussmöglichkeiten sozialer Bewegungen. Das Beispiel Jura-Konflikt
- Author
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Mark Eisenegger, University of Zurich, König, Mario, Kreis, Georg, Meister, Franziska, Romano, Gaetano, and Eisenegger, Mark
- Subjects
11211 Institute for Research on the Public Sphere and Society ,10240 Department of Communication and Media Research ,300 Social sciences, sociology & anthropology ,10095 Institute of Sociology - Published
- 1998
197. Mythos und Moderne. Zur Fragilität der posttraditionalen Gesellschaft
- Author
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Imhof, Kurt, University of Zurich, Bornschier, Volker, Eisner, Manuel, Imhof, Kurt, Romano, Gaetano, and Suter, Christian
- Subjects
11211 Institute for Research on the Public Sphere and Society ,10240 Department of Communication and Media Research ,300 Social sciences, sociology & anthropology ,070 News media, journalism & publishing ,10095 Institute of Sociology - Published
- 1990
198. Das Framing des Jura-Konflikts in der Deutschschweizer Presseöffentlichkeit 1947 bis 1968
- Author
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Mark Eisenegger, University of Zurich, Imhof, Kurt, Kleger, Heinz, Romano, Gaetano, and Eisenegger, Mark
- Subjects
11211 Institute for Research on the Public Sphere and Society ,10240 Department of Communication and Media Research ,300 Social sciences, sociology & anthropology ,10095 Institute of Sociology
199. Access of migrant women to sexual and reproductive health services: A systematic review.
- Author
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Pérez-Sánchez M, Immordino P, Romano G, Giordano A, García-Gil C, and Morales F
- Abstract
Background: The number of people living in a different place from their place of birth is increasing year by year. Although women have always been involved in migratory movements, today they are increasingly doing so independently. Women are migrating from the Global South to higher-income countries. One of the challenges they face is access to sexual and reproductive health (SRH) services., Aim: To identify the policy-level barriers that limit the access of migrant women to SRH services, their consequences, and strategies implemented to overcome these barriers., Methods: A systematic review of the literature was undertaken in accordance with the PRISMA statement. A search was undertaken for articles published between 2018 and 2023 focusing on migrant women's experiences of SRH services. In total, 462 articles were retrieved from PubMed (n = 135), Scopus (n = 94) and Web of Science (n = 233); of these, 28 articles were included in this review., Findings: The most common barrier to SRH services identified in the reviewed articles was lack of information (57 %), followed by language issues (43 %), cultural differences (39 %), economic status (25 %), administrative barriers (25 %) and discrimination (14 %). These barriers led to under-utilisation of maternity services and contraceptive methods. Strategies used by migrant women to overcome these barriers were primarily based on seeking help within their own community or family settings., Conclusion: Strategies at institutional level to improve the access of migrant women to SRH services need to reduce existing barriers, promote health literacy, and train health workers to be culturally sensitive and responsive to the needs of migrant women., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
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200. Robotic surgery for thymic cysts: clinical features, management, and results of a multicentric study.
- Author
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Cusumano G, Meacci E, Romano G, Cavaleri M, Congedo MT, Davini F, Margaritora S, Terminella A, and Melfi F
- Abstract
Thymic cysts are rare, radiological diagnosis is often incidental, and cysts seldom assume clinical relevance for symptoms of compression. Thymoma were occasionally found inside both complex and simple thymic cysts. Given the challenges in accurately clinical diagnosing and since the occasionally discovering of thymoma inside both complex and simple thymic cysts, the management of thymic cysts remains controversial. Advancements in surgical tools such as robotics, applied to thymic conditions, could potentially transform the approach to thymic cysts. We report one the largest multicentric series of thymic cysts surgically treated with robotic approach, focusing on preoperative findings and surgical results. Cases were gathered from three Italian thoracic surgery centers with homogeneous clinical practice, significant experience in thymic neoplasms, and thoracic robotic skilled. Surgical intervention was indicated for patients with radiological diagnosis of thymic cysts under the following circumstances: the presence of symptoms, concurrent myasthenia gravis, cysts growing in follow-up, and the complexity of the cyst with suspicion of neoplasm. Data were collected and matched according to postoperative and pathological features to identify potential prognostic factors. Population include 57 patients, 29/28 male/female ratio with mean age of 59.46 ± 11.67 years. The average size of the thymic cysts was 29.14 ± 24.53 ranged between 3 and 150 mm. All patients undergone CT scan and mean of values of density was 25.82 ± 11-82 Hounsfield. Surgical procedures were robotic approach in all case including total/extended thymectomy 35 (61.4%) and cyst resection/partial thymectomy 22 (38.6%). There were no mortality or recurrence. Major complications rate was 5.3%. No correlations were observed between preoperative features and complication. Pathological examination revealed microfoci of thymic tumor in four cases. Robot-assisted surgery for thymic cysts showed excellent early clinical outcomes with low rate of postoperative complications also in case of large lesion. Thymic cysts should not be underestimated due to the risk of coexistent thymic neoplasm., (© 2024. The Author(s).)
- Published
- 2024
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- View/download PDF
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