151. Clostridium perfringens type A–E toxin plasmids
- Author
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Freedman, John C, Theoret, James R, Wisniewski, Jessica A, Uzal, Francisco A, Rood, Julian I, and McClane, Bruce A
- Subjects
Microbiology ,Biological Sciences ,Foodborne Illness ,Genetics ,Infectious Diseases ,Digestive Diseases ,Emerging Infectious Diseases ,Infection ,Adaptation ,Biological ,Bacterial Toxins ,Clostridium perfringens ,Conjugation ,Genetic ,DNA Transposable Elements ,Gene Transfer ,Horizontal ,Plasmids ,Virulence Factors ,Plasmid-encoded toxin ,Clostridia ,Gastrointestinal disease ,Conjugation ,Plasmid evolution ,Medical Microbiology - Abstract
Clostridium perfringens relies upon plasmid-encoded toxin genes to cause intestinal infections. These toxin genes are associated with insertion sequences that may facilitate their mobilization and transfer, giving rise to new toxin plasmids with common backbones. Most toxin plasmids carry a transfer of clostridial plasmids locus mediating conjugation, which likely explains the presence of similar toxin plasmids in otherwise unrelated C. perfringens strains. The association of many toxin genes with insertion sequences and conjugative plasmids provides virulence flexibility when causing intestinal infections. However, incompatibility issues apparently limit the number of toxin plasmids maintained by a single cell.
- Published
- 2015