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1,259 results on '"Ruijter, Hester M."'

151. Sex-Stratified Gene Regulatory Networks Reveal Female Key Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching

Author

Experimentele Afd. Cardiologie 1, Circulatory Health, CDL Onderzoek Pasterkamp, Onderzoek Precision medicine, Child Health, Onderzoek Vrouw Hart & Vaatziekten, Hartman, Robin J G, Owsiany, Katie, Ma, Lijiang, Koplev, Simon, Hao, Ke, Slenders, Lotte, Civelek, Mete, Mokry, Michal, Kovacic, Jason C, Pasterkamp, Gerard, Owens, Gary, Björkegren, Johan L M, den Ruijter, Hester M, Experimentele Afd. Cardiologie 1, Circulatory Health, CDL Onderzoek Pasterkamp, Onderzoek Precision medicine, Child Health, Onderzoek Vrouw Hart & Vaatziekten, Hartman, Robin J G, Owsiany, Katie, Ma, Lijiang, Koplev, Simon, Hao, Ke, Slenders, Lotte, Civelek, Mete, Mokry, Michal, Kovacic, Jason C, Pasterkamp, Gerard, Owens, Gary, Björkegren, Johan L M, and den Ruijter, Hester M

Published
2021

152. The association of the Mediterranean diet with heart failure risk in a Dutch population

Author

Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, Team Medisch, Public Health Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 1, Strengers, Julia G, den Ruijter, Hester M, Boer, Jolanda M A, Asselbergs, Folkert W, Verschuren, W M Monique, van der Schouw, Yvonne T, Sluijs, Ivonne, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, Team Medisch, Public Health Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 1, Strengers, Julia G, den Ruijter, Hester M, Boer, Jolanda M A, Asselbergs, Folkert W, Verschuren, W M Monique, van der Schouw, Yvonne T, and Sluijs, Ivonne

Published
2021

153. Heart Size Corrected Electrical Dyssynchrony and Its Impact on Sex-specific Response to Cardiac Resynchronization Therapy

Author

Arts Assistenten Cardiologie, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, Team Medisch, Salden, Odette A E, van Stipdonk, Antonius M W, den Ruijter, Hester M, Cramer, Maarten Jan, Kloosterman, Mariëlle, Rienstra, Michiel, Maass, Alexander H, Prinzen, Frits W, Vernooy, Kevin, Meine, Mathias, Arts Assistenten Cardiologie, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, Team Medisch, Salden, Odette A E, van Stipdonk, Antonius M W, den Ruijter, Hester M, Cramer, Maarten Jan, Kloosterman, Mariëlle, Rienstra, Michiel, Maass, Alexander H, Prinzen, Frits W, Vernooy, Kevin, and Meine, Mathias

Published
2021

156. Additional file 4 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts

Author

Jiayi Pei, Harakalova, Magdalena, Treibel, Thomas A., R Thomas Lumbers, Boukens, Bastiaan J., Efimov, Igor R., Dinter, Jip T. Van, González, Arantxa, López, Begoña, Azzouzi, Hamid El, Dungen, Noortje Van Den, Dijk, Christian G. M. Van, Krebber, Merle M., Ruijter, Hester M. Den, Pasterkamp, Gerard, Duncker, Dirk J., Nieuwenhuis, Edward E. S., Weger, Roel De, Huibers, Manon M., Vink, Aryan, Moore, Jason H., Moon, James C., Verhaar, Marianne C., Kararigas, Georgios, Mokry, Michal, Asselbergs, Folkert W., and Cheng, Caroline

Abstract

Additional file 4 Supplementary Figure 4. The mRNA expression level of cell-type-specific markers. Genes labeled red and blue were significantly up- and downregulated in patients versus controls (p < 0.05).

Published
2020
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157. Additional file 13 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts

Author

Jiayi Pei, Harakalova, Magdalena, Treibel, Thomas A., R Thomas Lumbers, Boukens, Bastiaan J., Efimov, Igor R., Dinter, Jip T. Van, González, Arantxa, López, Begoña, Azzouzi, Hamid El, Dungen, Noortje Van Den, Dijk, Christian G. M. Van, Krebber, Merle M., Ruijter, Hester M. Den, Pasterkamp, Gerard, Duncker, Dirk J., Nieuwenhuis, Edward E. S., Weger, Roel De, Huibers, Manon M., Vink, Aryan, Moore, Jason H., Moon, James C., Verhaar, Marianne C., Kararigas, Georgios, Mokry, Michal, Asselbergs, Folkert W., and Cheng, Caroline

Abstract

Additional file 13. Supplementary Table 7. Overview of included samples in H3K27ac ChIP-seq, RNAPII ChIP-seq, and RNA-seq experiments.

Published
2020
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158. Additional file 5 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts

Author

Jiayi Pei, Harakalova, Magdalena, Treibel, Thomas A., R Thomas Lumbers, Boukens, Bastiaan J., Efimov, Igor R., Dinter, Jip T. Van, González, Arantxa, López, Begoña, Azzouzi, Hamid El, Dungen, Noortje Van Den, Dijk, Christian G. M. Van, Krebber, Merle M., Ruijter, Hester M. Den, Pasterkamp, Gerard, Duncker, Dirk J., Nieuwenhuis, Edward E. S., Weger, Roel De, Huibers, Manon M., Vink, Aryan, Moore, Jason H., Moon, James C., Verhaar, Marianne C., Kararigas, Georgios, Mokry, Michal, Asselbergs, Folkert W., and Cheng, Caroline

Abstract

Additional file 5. Supplementary Figure 5. Gene Ontology (GO) analysis of genes annotated to DARs using ToppFun. a Molecular function enrichment for hyperacetylated regions, b Biological process for hyperacetylated regions, c Cellular component for hyperacetylated regions, d Molecular function for hypoacetylated regions, e Biological process for hypoacetylated regions, f Cellular component for hypoacetylated regions.

Published
2020
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160. Circulating Neutrophils Do Not Predict Subclinical Coronary Artery Disease in Women with Former Preeclampsia

Author

Meeuwsen, John A.L., Vries, J. de, Zoet, Gerbrand A., Franx, Arie, Fauser, Bart C.J.M., Maas, A.H.E.M., Ruijter, Hester M. den, Jager, Saskia C.A. de, Meeuwsen, John A.L., Vries, J. de, Zoet, Gerbrand A., Franx, Arie, Fauser, Bart C.J.M., Maas, A.H.E.M., Ruijter, Hester M. den, and Jager, Saskia C.A. de

Abstract

Contains fulltext : 218086.pdf (publisher's version ) (Open Access)

Published
2020

161. Circulating Neutrophils Do Not Predict Subclinical Coronary Artery Disease in Women with Former Preeclampsia

Author

Meeuwsen, J.A.L., Vries, J. de, Zoet, Gerbrand A., Franx, Arie, Fauser, Bart C.J.M., Maas, A.H.E.M., Ruijter, Hester M. den, Jager, Saskia C.A. de, Meeuwsen, J.A.L., Vries, J. de, Zoet, Gerbrand A., Franx, Arie, Fauser, Bart C.J.M., Maas, A.H.E.M., Ruijter, Hester M. den, and Jager, Saskia C.A. de

Abstract

Contains fulltext : 218086.pdf (publisher's version ) (Open Access)

Published
2020

162. Sex-Specific Aspects in the Pathophysiology and Imaging of Coronary Macro- and Microvascular Disease

Author

CDL Onderzoek Pasterkamp, Onderzoek Vrouw Hart & Vaatziekten, Experimentele Afd. Cardiologie 1, Circulatory Health, Researchgr. Cardiovasculaire Radiologie, Groepenhoff, Floor, Bots, Sophie H, Kessler, Elise L, Sickinghe, Ariane A, Eikendal, Anouk L M, Leiner, Tim, den Ruijter, Hester M, CDL Onderzoek Pasterkamp, Onderzoek Vrouw Hart & Vaatziekten, Experimentele Afd. Cardiologie 1, Circulatory Health, Researchgr. Cardiovasculaire Radiologie, Groepenhoff, Floor, Bots, Sophie H, Kessler, Elise L, Sickinghe, Ariane A, Eikendal, Anouk L M, Leiner, Tim, and den Ruijter, Hester M

Published
2020

163. Sex-specific thoracic aortic dimensions and clinical implications

Author

CDL Onderzoek Pasterkamp, Experimentele Afd. Cardiologie 1, Circulatory Health, Groepenhoff, Floor, den Ruijter, Hester M, CDL Onderzoek Pasterkamp, Experimentele Afd. Cardiologie 1, Circulatory Health, Groepenhoff, Floor, and den Ruijter, Hester M

Published
2020

164. Cardiovascular imaging of women and men visiting the outpatient clinic with chest pain or discomfort: design and rationale of the ARGUS Study

Author

CDL Onderzoek Pasterkamp, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, Experimentele Afd. Cardiologie 1, CDL Upod, Cardiovasculaire Epi Team 3, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Arcadia, Researchgr. Cardiovasculaire Radiologie, Groepenhoff, Floor, Eikendal, Anouk L M, Bots, Sophie Heleen, van Ommen, Anne-Mar, Overmars, L M, Kapteijn, Daniek, Pasterkamp, Gerard, Reiber, Johan H C, Hautemann, David, Menken, Roxana, Wittekoek, Marianne E, Hofstra, Leonard, Onland-Moret, N Charlotte, Haitjema, Saskia, Hoefer, Imo, Leiner, Tim, den Ruijter, Hester M, CDL Onderzoek Pasterkamp, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, Experimentele Afd. Cardiologie 1, CDL Upod, Cardiovasculaire Epi Team 3, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Arcadia, Researchgr. Cardiovasculaire Radiologie, Groepenhoff, Floor, Eikendal, Anouk L M, Bots, Sophie Heleen, van Ommen, Anne-Mar, Overmars, L M, Kapteijn, Daniek, Pasterkamp, Gerard, Reiber, Johan H C, Hautemann, David, Menken, Roxana, Wittekoek, Marianne E, Hofstra, Leonard, Onland-Moret, N Charlotte, Haitjema, Saskia, Hoefer, Imo, Leiner, Tim, and den Ruijter, Hester M

Published
2020

165. The age- and sex-specific composition of atherosclerotic plaques in vascular surgery patients

Author

Zorgeenheid Vaatchirurgie Medisch, Experimentele Afd. Cardiologie 1, Circulatory Health, Infection & Immunity, Brain, Regenerative Medicine and Stem Cells, CDL Onderzoek Pasterkamp, Onderzoek Vrouw Hart & Vaatziekten, de Bakker, Marie, Timmerman, Nathalie, van Koeverden, Ian D, de Kleijn, Dominique P V, de Borst, Gert J, Pasterkamp, Gerard, Boersma, Eric, den Ruijter, Hester M, Zorgeenheid Vaatchirurgie Medisch, Experimentele Afd. Cardiologie 1, Circulatory Health, Infection & Immunity, Brain, Regenerative Medicine and Stem Cells, CDL Onderzoek Pasterkamp, Onderzoek Vrouw Hart & Vaatziekten, de Bakker, Marie, Timmerman, Nathalie, van Koeverden, Ian D, de Kleijn, Dominique P V, de Borst, Gert J, Pasterkamp, Gerard, Boersma, Eric, and den Ruijter, Hester M

Published
2020

166. Preemptive Stenting of the Vulnerable Plaque: Fixing a Dogma?

Author

CDL Onderzoek Pasterkamp, Circulatory Health, Utrecht Palliatie Centrum, Team Medisch, Onderzoek Vrouw Hart & Vaatziekten, Pasterkamp, Gerard, van der Harst, Pim, den Ruijter, Hester M, CDL Onderzoek Pasterkamp, Circulatory Health, Utrecht Palliatie Centrum, Team Medisch, Onderzoek Vrouw Hart & Vaatziekten, Pasterkamp, Gerard, van der Harst, Pim, and den Ruijter, Hester M

Published
2020

167. Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

Author

CDL Onderzoek Pasterkamp, Child Health, Infection & Immunity, Experimentele Afd. Cardiologie 1, Experimentele Afd. Cardiologie 2, Circulatory Health, Onderzoek Molecular Cardiology, Team Medisch, Zorgeenheid Vaatchirurgie Medisch, Brain, Regenerative Medicine and Stem Cells, Onderzoek Vrouw Hart & Vaatziekten, Wetensch. Onderwijs Kindergeneeskunde, Onderzoek Precision medicine, Depuydt, Marie Ac, Prange, Koen Hm, Slenders, Lotte, Örd, Tiit, Elbersen, Danny, Boltjes, Arjan, de Jager, Saskia Ca, Asselbergs, Folkert W, de Borst, Gert J, Aavik, Einari, Lönnberg, Tapio, Lutgens, Esther, Glass, Christopher K, den Ruijter, Hester M, Kaikkonen, Minna U, Bot, Ilze, Slütter, Bram, van der Laan, Sander W, Yla-Herttuala, Seppo, Mokry, Michal, Kuiper, Johan, de Winther, Menno Pj, Pasterkamp, Gerard, CDL Onderzoek Pasterkamp, Child Health, Infection & Immunity, Experimentele Afd. Cardiologie 1, Experimentele Afd. Cardiologie 2, Circulatory Health, Onderzoek Molecular Cardiology, Team Medisch, Zorgeenheid Vaatchirurgie Medisch, Brain, Regenerative Medicine and Stem Cells, Onderzoek Vrouw Hart & Vaatziekten, Wetensch. Onderwijs Kindergeneeskunde, Onderzoek Precision medicine, Depuydt, Marie Ac, Prange, Koen Hm, Slenders, Lotte, Örd, Tiit, Elbersen, Danny, Boltjes, Arjan, de Jager, Saskia Ca, Asselbergs, Folkert W, de Borst, Gert J, Aavik, Einari, Lönnberg, Tapio, Lutgens, Esther, Glass, Christopher K, den Ruijter, Hester M, Kaikkonen, Minna U, Bot, Ilze, Slütter, Bram, van der Laan, Sander W, Yla-Herttuala, Seppo, Mokry, Michal, Kuiper, Johan, de Winther, Menno Pj, and Pasterkamp, Gerard

Published
2020

168. Sex-specific microRNAs in women with diabetes and left ventricular diastolic dysfunction or HFpEF associate with microvascular injury

Author

Onderzoek Vrouw Hart & Vaatziekten, Team Medisch, Circulatory Health, HAG Hart- Vaatziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Florijn, Barend W., Valstar, Gideon B., Duijs, Jacques M.G.J., Menken, Roxana, Cramer, Maarten J., Teske, Arco J., Ghossein-Doha, Chahinda, Rutten, Frans H., Spaanderman, Marc E.A., den Ruijter, Hester M., Bijkerk, Roel, van Zonneveld, Anton Jan, Onderzoek Vrouw Hart & Vaatziekten, Team Medisch, Circulatory Health, HAG Hart- Vaatziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Florijn, Barend W., Valstar, Gideon B., Duijs, Jacques M.G.J., Menken, Roxana, Cramer, Maarten J., Teske, Arco J., Ghossein-Doha, Chahinda, Rutten, Frans H., Spaanderman, Marc E.A., den Ruijter, Hester M., Bijkerk, Roel, and van Zonneveld, Anton Jan

Published
2020

169. H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts

Author

Onderzoek Precision medicine, Other research (not in main researchprogram), Cardiologie Arts-onderzoekers, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, CDL Onderzoek Pasterkamp, UMC Utrecht, Onderzoek, MDL onderzoek 1, Infection & Immunity, Child Health, Pathologie Laboratorium diagnostiek, Genetica Sectie Genoomdiagnostiek, Pathologie Pathologen staf, Team Medisch, Pei, Jiayi, Harakalova, Magdalena, Treibel, Thomas A, Lumbers, R Thomas, Boukens, Bastiaan J, Efimov, Igor R, van Dinter, Jip T, González, Arantxa, López, Begoña, El Azzouzi, Hamid, van den Dungen, Noortje, van Dijk, Christian G M, Krebber, Merle M, den Ruijter, Hester M, Pasterkamp, Gerard, Duncker, Dirk J, Nieuwenhuis, Edward E S, de Weger, Roel, Huibers, Manon M, Vink, Aryan, Moore, Jason H, Moon, James C, Verhaar, Marianne C, Kararigas, Georgios, Mokry, Michal, Asselbergs, Folkert W, Cheng, Caroline, Onderzoek Precision medicine, Other research (not in main researchprogram), Cardiologie Arts-onderzoekers, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, CDL Onderzoek Pasterkamp, UMC Utrecht, Onderzoek, MDL onderzoek 1, Infection & Immunity, Child Health, Pathologie Laboratorium diagnostiek, Genetica Sectie Genoomdiagnostiek, Pathologie Pathologen staf, Team Medisch, Pei, Jiayi, Harakalova, Magdalena, Treibel, Thomas A, Lumbers, R Thomas, Boukens, Bastiaan J, Efimov, Igor R, van Dinter, Jip T, González, Arantxa, López, Begoña, El Azzouzi, Hamid, van den Dungen, Noortje, van Dijk, Christian G M, Krebber, Merle M, den Ruijter, Hester M, Pasterkamp, Gerard, Duncker, Dirk J, Nieuwenhuis, Edward E S, de Weger, Roel, Huibers, Manon M, Vink, Aryan, Moore, Jason H, Moon, James C, Verhaar, Marianne C, Kararigas, Georgios, Mokry, Michal, Asselbergs, Folkert W, and Cheng, Caroline

Published
2020

170. Intrinsic transcriptomic sex differences in human endothelial cells at birth and in adults are associated with coronary artery disease targets

Author

Experimentele Afd. Cardiologie 1, Circulatory Health, CDL Arcadia, MS Verloskunde, Child Health, Onderzoek Precision medicine, CDL Onderzoek Pasterkamp, Onderzoek Vrouw Hart & Vaatziekten, Hartman, Robin J G, Kapteijn, Daniek M C, Haitjema, Saskia, Bekker, Mireille N, Mokry, Michal, Pasterkamp, Gerard, Civelek, Mete, den Ruijter, Hester M, Experimentele Afd. Cardiologie 1, Circulatory Health, CDL Arcadia, MS Verloskunde, Child Health, Onderzoek Precision medicine, CDL Onderzoek Pasterkamp, Onderzoek Vrouw Hart & Vaatziekten, Hartman, Robin J G, Kapteijn, Daniek M C, Haitjema, Saskia, Bekker, Mireille N, Mokry, Michal, Pasterkamp, Gerard, Civelek, Mete, and den Ruijter, Hester M

Published
2020

171. Cerebral Small Vessel Disease in Standard Pre-operative Imaging Reports Is Independently Associated with Increased Risk of Cardiovascular Death Following Carotid Endarterectomy

Author

Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, CDL Arcadia, Onderzoek Vrouw Hart & Vaatziekten, CDL Onderzoek Pasterkamp, ZL Cerebrovasculaire Ziekten Medisch, Brain, Infection & Immunity, Regenerative Medicine and Stem Cells, Timmerman, Nathalie, Rots, Marjolijn L, van Koeverden, Ian D, Haitjema, Saskia, van Laarhoven, Constance J H C M, Vuurens, Annemiek M, den Ruijter, Hester M, Pasterkamp, Gerard, Kappelle, L Jaap, de Kleijn, Dominique P V, de Borst, Gert J, Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, CDL Arcadia, Onderzoek Vrouw Hart & Vaatziekten, CDL Onderzoek Pasterkamp, ZL Cerebrovasculaire Ziekten Medisch, Brain, Infection & Immunity, Regenerative Medicine and Stem Cells, Timmerman, Nathalie, Rots, Marjolijn L, van Koeverden, Ian D, Haitjema, Saskia, van Laarhoven, Constance J H C M, Vuurens, Annemiek M, den Ruijter, Hester M, Pasterkamp, Gerard, Kappelle, L Jaap, de Kleijn, Dominique P V, and de Borst, Gert J

Published
2020

172. Family history and polygenic risk of cardiovascular disease: Independent factors associated with secondary cardiovascular events in patients undergoing carotid endarterectomy

Author

Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, Infection & Immunity, Brain, Regenerative Medicine and Stem Cells, Experimentele Afd. Cardiologie 1, Team Medisch, CDL Onderzoek Pasterkamp, dLAB Afdelingen, CDL Arcadia, Timmerman, Nathalie, de Kleijn, Dominique P.V., de Borst, Gert J., den Ruijter, Hester M., Asselbergs, Folkert W., Pasterkamp, Gerard, Haitjema, Saskia, van der Laan, Sander W., Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, Infection & Immunity, Brain, Regenerative Medicine and Stem Cells, Experimentele Afd. Cardiologie 1, Team Medisch, CDL Onderzoek Pasterkamp, dLAB Afdelingen, CDL Arcadia, Timmerman, Nathalie, de Kleijn, Dominique P.V., de Borst, Gert J., den Ruijter, Hester M., Asselbergs, Folkert W., Pasterkamp, Gerard, Haitjema, Saskia, and van der Laan, Sander W.

Published
2020

173. Circulating Neutrophils Do Not Predict Subclinical Coronary Artery Disease in Women with Former Preeclampsia

Author

BMW Algemeen, Circulatory Health, Arts-assistenten DV&B, MS Verloskunde, Brain, MS VPG/Gynaecologie, Researchgr. Hart-brein as., Interne Geneeskunde Vasculaire, CDL Onderzoek Pasterkamp, dLAB Afdelingen, CDL Arcadia, Experimentele Afd. Cardiologie 1, Experimentele Afd. Cardiologie 2, Meeuwsen, John A.L., de Vries, Judith, Zoet, Gerbrand A., Franx, Arie, Fauser, Bart C.J.M., Maas, Angela H.E.M., Velthuis, Birgitta K., Appelman, Yolande E., Visseren, Frank L., Pasterkamp, Gerard, Hoefer, Imo E., van Rijn, Bas B., den Ruijter, Hester M., de Jager, Saskia C.A., BMW Algemeen, Circulatory Health, Arts-assistenten DV&B, MS Verloskunde, Brain, MS VPG/Gynaecologie, Researchgr. Hart-brein as., Interne Geneeskunde Vasculaire, CDL Onderzoek Pasterkamp, dLAB Afdelingen, CDL Arcadia, Experimentele Afd. Cardiologie 1, Experimentele Afd. Cardiologie 2, Meeuwsen, John A.L., de Vries, Judith, Zoet, Gerbrand A., Franx, Arie, Fauser, Bart C.J.M., Maas, Angela H.E.M., Velthuis, Birgitta K., Appelman, Yolande E., Visseren, Frank L., Pasterkamp, Gerard, Hoefer, Imo E., van Rijn, Bas B., den Ruijter, Hester M., and de Jager, Saskia C.A.

Published
2020

175. Sex-dependent gene regulation of human atherosclerotic plaques by DNA methylation and transcriptome integration points to smooth muscle cell involvement in women

Author

Hartman, Robin J. G., primary, Siemelink, Marten A., additional, Haitjema, Saskia, additional, Dekkers, Koen F., additional, Slenders, Lotte, additional, Boltjes, Arjan, additional, Mokry, Michal, additional, Timmerman, Nathalie, additional, de Borst, Gert J., additional, Heijmans, Bastiaan T., additional, Asselbergs, Folkert W., additional, Pasterkamp, Gerard, additional, van der Laan, Sander W., additional, and den Ruijter, Hester M., additional

Published
2021
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178. Transcriptional regulation profiling reveals disrupted lipid metabolism in failing hearts with a pathogenic phospholamban mutation

Author

Pei, Jiayi, primary, Maas, Renee G.C., additional, Nagyova, Ema, additional, Gho, Johannes M.I.H., additional, Blok, Christian Snijders, additional, van Adrichem, Iris, additional, Calis, Jorg J.A., additional, van Es, René, additional, Sepehrkhouy, Shahrzad, additional, Feyen, Dries, additional, van den Dungen, Noortje, additional, Lansu, Nico, additional, de Jonge, Nicolaas, additional, den Ruijter, Hester M., additional, Huibers, Manon M.H., additional, de Weger, Roel A., additional, van Laake, Linda W., additional, Verhaar, Marianne C., additional, van Tintelen, Peter, additional, van Steenbeek, Frank G., additional, van Mil, Alain, additional, Buikema, Jan W., additional, Burgering, Boudewijn, additional, Kararikes, Ioannis, additional, Mercola, Mark, additional, Doevendans, Pieter A., additional, Sluijter, Joost, additional, Vink, Aryan, additional, Cheng, Caroline, additional, Mokry, Michal, additional, Asselbergs, Folkert W., additional, and Harakalova, Magdalena, additional

Published
2020
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179. Cardiovascular imaging of women and men visiting the outpatient clinic with chest pain or discomfort: design and rationale of the ARGUS Study

Author

Groepenhoff, Floor, primary, Eikendal, Anouk L M, additional, Bots, Sophie Heleen, additional, van Ommen, Anne-Mar, additional, Overmars, L M, additional, Kapteijn, Daniek, additional, Pasterkamp, Gerard, additional, Reiber, Johan H C, additional, Hautemann, David, additional, Menken, Roxana, additional, Wittekoek, Marianne E, additional, Hofstra, Leonard, additional, Onland-Moret, N Charlotte, additional, Haitjema, Saskia, additional, Hoefer, Imo, additional, Leiner, Tim, additional, and den Ruijter, Hester M, additional

Published
2020
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184. Heart failure with preserved, mid‐range, and reduced ejection fraction across health care settings: an observational study.

Author

de Boer, Annemarijn R., Vaartjes, Ilonca, Gohar, Aisha, Valk, Mark J.M., Brugts, Jasper J., Boonman‐de Winter, Leandra J.M., van Riet, Evelien E., van Mourik, Yvonne, Brunner‐La Rocca, Hans‐Peter, Linssen, Gerard C.M., Hoes, Arno W., Bots, Michiel L., den Ruijter, Hester M., and Rutten, Frans H.

Subjects
HEART failure patients, MEDICAL care
Abstract

Aims: This study aimed to assess the sex‐specific distribution of heart failure (HF) with preserved, mid‐range, and reduced ejection fraction across three health care settings. Methods and results: In this descriptive observational study, we retrieved the distribution of HF types [with reduced ejection fraction (HFrEF), mid‐range ejection fraction (HFmrEF), and preserved ejection fraction (HFpEF)] for men and women between 65 and 79 years of age in three health care settings from a single country: (i) patients with screening‐detected HF in the high‐risk community (i.e. those with shortness of breath, frailty, diabetes mellitus, and chronic obstructive pulmonary disease) from four screening studies, (ii) patients with confirmed HF from primary care derived from a single observational study, and (iii) patients with confirmed HF from outpatient cardiology clinics participating in a registry. Among 1407 patients from the high‐risk community, 288 had screen‐detected HF (15% HFrEF, 12% HFmrEF, 74% HFpEF), and 51% of the screen‐detected HF patients were women. In both women (82%) and men (65%), HFpEF was the most prevalent HF type. In the routine general practice population (30 practices, 70 000 individuals), among the 160 confirmed HF cases, 35% had HFrEF, 23% HFmrEF, and 43% HFpEF, and in total, 43% were women. In women, HFpEF was the most prevalent HF type (52%), while in men, this was HFrEF (41%). In outpatient cardiology clinics (n = 34), of the 4742 HF patients (66% HFrEF, 15% HFmrEF, 20% HFpEF), 36% were women. In both women (56%) and men (71%), HFrEF was the most prevalent HF type. Conclusions: Both HF types and sex distribution vary considerably in HF patients of 65–79 years of age among health care settings. From the high‐risk community through to general practice to the cardiology outpatient setting, there is a shift in HF type from HFpEF to HFrEF and a decrease in the proportion of HF patients that are women. [ABSTRACT FROM AUTHOR]

Published
2022
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187. Common Carotid Intima-Media Thickness Measurements in Cardiovascular Risk Prediction: A Meta-analysis

Author

Den Ruijter, Hester M., Peters, Sanne A., Anderson, Todd J., Britton, Annie R., Dekker, Jacqueline M., Eijkemans, Marinus J., Engström, Gunnar, Evans, Gregory W., de Graaf, Jacqueline, Grobbee, Diederick E., Hedblad, Bo, Hofman, Albert, Holewijn, Suzanne, Ikeda, Ai, Kavousi, Maryam, Kitagawa, Kazuo, Kitamura, Akihiko, Koffijberg, Hendrik, Lonn, Eva M., Lorenz, Matthias W., Mathiesen, Ellisiv B., Nijpels, Giel, Okazaki, Shuhei, O’Leary, Daniel H., Polak, Joseph F., Price, Jackie F., Robertson, Christine, Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Sitzer, Matthias, Stehouwer, Coen D., Witteman, Jacqueline C., Moons, Karel G., and Bots, Michiel L.

Published
2012
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191. Risk of bias in studies investigating novel diagnostic biomarkers for heart failure with preserved ejection fraction. A systematic review

Author

Henkens, Michiel T.H.M., primary, Remmelzwaal, Sharon, additional, Robinson, Emma L., additional, Ballegooijen, Adriana J., additional, Barandiarán Aizpurua, Arantxa, additional, Verdonschot, Job A.J., additional, Raafs, Anne G., additional, Weerts, Jerremy, additional, Hazebroek, Mark R., additional, Sanders‐van Wijk, Sandra, additional, Handoko, M. Louis, additional, Ruijter, Hester M., additional, Lam, Carolyn S.P., additional, Boer, Rudolf A., additional, Paulus, Walter J., additional, Empel, Vanessa P.M., additional, Vos, Rein, additional, Brunner‐La Rocca, Hans‐Peter, additional, Beulens, Joline W.J., additional, and Heymans, Stephane R.B., additional

Published
2020
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192. Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart

Author

Perrino, Cinzia, primary, Ferdinandy, Péter, additional, Bøtker, Hans E, additional, Brundel, Bianca J J M, additional, Collins, Peter, additional, Davidson, Sean M, additional, den Ruijter, Hester M, additional, Engel, Felix B, additional, Gerdts, Eva, additional, Girao, Henrique, additional, Gyöngyösi, Mariann, additional, Hausenloy, Derek J, additional, Lecour, Sandrine, additional, Madonna, Rosalinda, additional, Marber, Michael, additional, Murphy, Elizabeth, additional, Pesce, Maurizio, additional, Regitz-Zagrosek, Vera, additional, Sluijter, Joost P G, additional, Steffens, Sabine, additional, Gollmann-Tepeköylü, Can, additional, Van Laake, Linda W, additional, Van Linthout, Sophie, additional, Schulz, Rainer, additional, and Ytrehus, Kirsti, additional

Published
2020
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195. Circulating Neutrophils Do Not Predict Subclinical Coronary Artery Disease in Women with Former Preeclampsia

Author

Meeuwsen, John A.L., primary, de Vries, Judith, additional, Zoet, Gerbrand A., additional, Franx, Arie, additional, Fauser, Bart C. J. M., additional, Maas, Angela H. E. M., additional, Velthuis, Birgitta K., additional, Appelman, Yolande E., additional, Visseren, Frank L., additional, Pasterkamp, Gerard, additional, Hoefer, Imo E., additional, van Rijn, Bas B., additional, den Ruijter, Hester M., additional, and de Jager, Saskia C.A., additional

Published
2020
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199. Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe:Results From the BiomarCaRE Consortium

Author

Magnussen, Christina, Niiranen, Teemu J., Ojeda, Francisco M., Gianfagna, Francesco, Blankenberg, Stefan, Vartiainen, Erkki, Sans, Susana, Pasterkamp, Gerard, Hughes, Maria, Costanzo, Simona, Donati, Maria Benedetta, Jousilahti, Pekka, Linneberg, Allan, Palosaari, Tarja, de Gaetano, Giovanni, Bobak, Martin, den Ruijter, Hester M., Jørgensen, Torben, Söderberg, Stefan, Kuulasmaa, Kari, Zeller, Tanja, Iacoviello, Licia, Salomaa, Veikko, and Schnabel, Renate B.

Subjects
biomarkers, cohort, epidemiology, heart failure, mortality, sex, Cardiology and Cardiovascular Medicine
Abstract

Objectives: This study investigates differences between women and men in heart failure (HF) risk and mortality. Background: Sex differences in HF epidemiology are insufficiently understood. Methods: In 78,657 individuals (median 49.5 years of age; age range 24.1 to 98.7 years; 51.7% women) from community-based European studies (FINRISK, DanMONICA, Moli-sani, Northern Sweden) of the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium, the association between incident HF and mortality, the relationship of cardiovascular risk factors, prevalent cardiovascular diseases, biomarkers (C-reactive protein [CRP]; N-terminal pro–B-type natriuretic peptide [NT-proBNP]) with incident HF, and their attributable risks were tested in women vs. men. Results: Over a median follow-up of 12.7 years, fewer HF cases were observed in women (n = 2,399 [5.9%]) than in men (n = 2,771 [7.3%]). HF incidence increased markedly after 60 years of age, initially with a more rapid increase in men, whereas incidence in women exceeded that of men after 85 years of age. HF onset substantially increased mortality risk in both sexes. Multivariable-adjusted Cox models showed the following sex differences for the association with incident HF: systolic blood pressure hazard ratio (HR) according to SD in women of 1.09 (95% confidence interval [CI]: 1.05 to 1.14) versus HR of 1.19 (95% CI: 1.14 to 1.24) in men; heart rate HR of 0.98 (95% CI: 0.93 to 1.03) in women versus HR of 1.09 (95% CI: 1.04 to 1.13) in men; CRP HR of 1.10 (95% CI: 1.00 to 1.20) in women versus HR of 1.32 (95% CI: 1.24 to 1.41) in men; and NT-proBNP HR of 1.54 (95% CI: 1.37 to 1.74) in women versus HR of 1.89 (95% CI: 1.75 to 2.05) in men. Population-attributable risk of all risk factors combined was 59.0% in women and 62.9% in men. Conclusions: Women had a lower risk for HF than men. Sex differences were seen for systolic blood pressure, heart rate, CRP, and NT-proBNP, with a lower HF risk in women.

Published
2019

200. Adverse Drug Reactions to Guideline-Recommended Heart Failure Drugs in Women : A Systematic Review of the Literature

Author

Bots, Sophie H, Groepenhoff, Floor, Eikendal, Anouk L M, Tannenbaum, Cara, Rochon, Paula A, Regitz-Zagrosek, Vera, Miller, Virginia M, Day, Danielle, Asselbergs, Folkert W, and den Ruijter, Hester M

Subjects
sex differences, adverse drug reactions, Journal Article, heart failure, sex-specific reporting, women
Abstract

OBJECTIVES: This study sought to summarize all available evidence on sex differences in adverse drug reactions (ADRs) to heart failure (HF) medication. BACKGROUND: Women are more likely to experience ADRs than men, and these reactions may negatively affect women's immediate and long-term health. HF in particular is associated with increased ADR risk because of the high number of comorbidities and older age. However, little is known about ADRs in women with HF who are treated with guideline-recommended drugs. METHODS: A systematic search of PubMed and EMBASE was performed to collect all available information on ADRs to angiotensin-converting enzyme inhibitors, β-blockers, angiotensin II receptor blockers, mineralocorticoid receptor antagonists, ivabradine, and digoxin in both women and men with HF. RESULTS: The search identified 155 eligible records, of which only 11 (7%) reported ADR data for women and men separately. Sex-stratified reporting of ADRs did not increase over the last decades. Six of the 11 studies did not report sex differences. Three studies reported a higher risk of angiotensin-converting enzyme inhibitor-related ADRs in women, 1 study showed higher digoxin-related mortality risk for women, and 1 study reported a higher risk of mineralocorticoid receptor antagonist-related ADRs in men. No sex differences in ADRs were reported for angiotensin II receptor blockers and β-blockers. Sex-stratified data were not available for ivabradine. CONCLUSIONS: These results underline the scarcity of ADR data stratified by sex. The study investigators call for a change in standard scientific practice toward reporting of ADR data for women and men separately.

Published
2019

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