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170. Dall'iperglicemia occasionale al MODY

Author

D'Annunzio, G, Alibrandi, A, Vitali, L, Avanzini, Ma, Martinetti, M, Barbetti, F, Lorini, RENATA GIUSEPPINA, and Severi, F.

Published
1999

174. Hypothalamic-pituitary vascularization in pituitary stalk transection syndrome: is the pituitary stalk really transected? The role of gadolinium-DTPA with spin-echo T1 imaging and turbo-FLASH technique

Author

Genovese, E, Maghnie, Mohamad, Beluffi, G, Villa, A, Sammarchi, L, Severi, F, and Campani, R.

Subjects
Adult, Gadolinium DTPA, Male, Adolescent, Hypothalamus, Contrast Media, Hypothalamus, Middle, Gadolinium, diagnosis/etiology, Pentetic Acid, Middle, Magnetic Resonance Imaging, Hypopituitarism, blood supply/pathology, Adolescent, Adult, Child, Contrast Media, Female, Gadolinium DTPA, Gadolinium, diagnostic use, Humans, Hypopituitarism, diagnosis/etiology, Hypothalamus, blood supply/pathology, Magnetic Resonance Imaging, Male, Organometallic Compounds, diagnostic use, Pentetic Acid, analogs /&/ derivatives/diagnostic use, Pituitary Gland, abnormalities/blood supply/pathology, Pituitary Gland, analogs /&/ derivatives/diagnostic use, Organometallic Compounds, Humans, Female, diagnostic use, Child
Abstract

We examined 14 patients, aged 10-25 years, with idiopathic hypopituitarism. All presented an ectopic posterior pituitary at the median eminence with a hypoplastic anterior pituitary on magnetic resonance imaging (MRI). Eight patients had isolated growth hormone deficit (IGHD) and six had multiple hormone deficits (MPHD). Unenhanced MRI showed the pituitary stalk, which was extremely thin, in only three patients, while T1-weighted images obtained after intravenous injection of gadopentetate dimeglumine (Gd-DTPA) showed a thin pituitary stalk in seven patients (six with IGHD and one with MPHD), demonstrating a preserved vascular component of the stalk. MRI with Gd-DTPA was more sensitive than unenhanced MRI in detecting the pituitary stalk in patients with hypopituitarism with an ectopic posterior pituitary: the stalk was demonstrated in 50 % of the cases (seven patients), versus 21.4 % (three patients) by unenhanced MRI. The dynamic study of the hypothalamo-hypophyseal axis performed with turbo-FLASH sequences after bolus injection of Gd-DTPA showed the residual anterior pituitary to have arterial enhancement times, which suggests that an arterial system compensates for the absent or diminished blood supply from the portal system, independent of stalk detection.

Published
1997

179. Myelodysplastic syndromes: the pediatric point of view

Author

Locatelli, F., Marco Zecca, Pession, A., Maserati, E., Stefano, P., and Severi, F.

Subjects
bone marrow transplantation, juvenile chronic myelogenous leukemia, monosomy 7, myelodysplastic syndromes, oncogenes
Published
1995

190. RD19: status report on 1993 development of hybrid and monolithic silicon micropattern detectors

Author

Anghinolfi, Francis, Antinori, Federico, Beker, H, Barberis, D, Bass, K, Batignani, G, Beutsch, W, Bonvicini, V, Bonzom, V, Bosisio, L, Boutonnet, C, Burger, P, Campbell, M, Cantoni, P, Catanesi, M G, Chesi, Enrico Guido, Claeys, C, Clemens, J C, Cohen-Solal, N, Darbo, G, Da Silva, J C, Da Vià, C, Debusschere, I, Delpierre, P A, Di Bari, D, Di Liberto, S, Dierickx, B, Elia, D, Enz, C C, Focardi, E, Forti, F, Gally, Y, Glaser, M, Gys, Thierry, Habrard, M C, Hallewell, G D, Heijne, Erik H M, Hermans, L, Heuser, J M, Inzani, P, Jacholkowski, A, Jaeger, J J, Jakubek, J, Jarron, P, Jirousek, P, Kersten, S, Krummenacher, F, Leitner, R, Lemeilleur, F, Lenti, V, Letheren, M F, Lokajícek, M, López, L, Loukas, D, Lo Vetere, M, MacDermott, M, Maggi, G, Manzari, V, Martinengo, P, Meddeler, G, Meddi, F, Mekkaoui, A, Middelkamp, P, Morando, M, Munns, A, Musico, P, Nava, P, Navach, F, Pallavicini, M, Pellegrini, F, Pengg, F X, Pindo, M, Pospísil, S, Potheau, R, Quercigh, Emanuele, Redaelli, N G, Rídky, J, Rossi, L, Safarík, K, Sauvage, D, Segato, G F, Severi, F, Simone, S, Smith, K, Sopko, B, Stefanini, G, Tempesta, P, Tonelli, G, Vegni, G, Verweij, H, Viertel, Gert M, Vrba, V, Waisbard, J, Damoiseaux, Magali, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and RD19

Subjects
[PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques
Published
1994

195. MR of the hypothalamic-pituitary axis in Langerhans cell histiocytosis

Author

Maghnie M, Maurizio Arico', Villa A, Genovese E, Beluffi G, and Severi F

Subjects
Gadolinium DTPA, Male, Hypothalamo-Hypophyseal System, endocrine system diseases, Adolescent, etiology, Contrast Media, urologic and male genital diseases, Adolescent, Child, Child, Preschool, Contrast Media, Diabetes Insipidus, etiology, Female, Gadolinium DTPA, Histiocytosis, Langerhans-Cell, complications/diagnosis, Humans, Hypothalamo-Hypophyseal System, pathology, Infant, Magnetic Resonance Imaging, Male, Organometallic Compounds, diagnostic use, Pentetic Acid, diagnostic use, Pituitary Gland, pathology, Journal Article, Organometallic Compounds, Humans, Child, Preschool, digestive, oral, and skin physiology, Infant, complications/diagnosis, Pentetic Acid, Magnetic Resonance Imaging, female genital diseases and pregnancy complications, Histiocytosis, Langerhans-Cell, Child, Preschool, Pituitary Gland, Female, diagnostic use, Histiocytosis, hormones, hormone substitutes, and hormone antagonists, Diabetes Insipidus
Abstract

PURPOSE: To describe the MR findings in the hypothalamic pituitary area in children with Langerhans cell histiocytosis and to define those MR alterations especially associated with the risk of developing diabetes insipidus. METHODS: The hypothalamic-neurohypophyseal axis was studied by sagittal and coronal 1.5 T1-weighted MR imaging in 14 children with Langerhans cell histiocytosis (five with diabetes insipidus) and in 28 low-stature controls, ages 6-14 years. RESULTS: The pituitary stalk was thicker in seven/14 patients (three with diabetes insipidus) than in controls (P less than .05). Bright posterior pituitary signal was undetectable in children with diabetes insipidus and in one/9 without diabetes insipidus. CONCLUSIONS: Thickening of the hypothalamus and/or the pituitary stalk in the absence of the posterior pituitary bright signal is seen in children with Langerhans cell histiocytosis with overt diabetes insipidus. Those Langerhans cell histiocytosis patients without diabetes insipidus but showing thickened stalk with or without posterior pituitary bright signal could be at high risk to develop diabetes insipidus.

Published
1992

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