Search

Your search keyword '"SHIBATA, TOMOYUKI"' showing total 1,275 results
Start Over Author "SHIBATA, TOMOYUKI"
1,275 results on '"SHIBATA, TOMOYUKI"'

153. Sa1927 CHANGES IN FECAL MICROBIOTA, SHORT CHAIN FATTY ACIDS, AND BILE ACIDS AFTER FECAL MICROBIOTA TRANSPLANTATION FOR RECURRENT CLOSTRIDIOIDES DIFFICILE INFECTION, ULCERATIVE COLITIS, AND CROHN'S DISEASE

Author

Ohmiya, Naoki, primary, Osaki, Hayato, additional, Jodai, Yasutaka, additional, Koyama, Keishi, additional, Maeda, Kohei, additional, Omori, Takafumi, additional, Komura, Naruomi, additional, Kamano, Toshiaki, additional, Funasaka, Kohei, additional, Nagasaka, Mitsuo, additional, Nakagawa, Yoshihito, additional, and Shibata, Tomoyuki, additional

Published
2020
Full Text
View/download PDF

156. Understanding Barriers and Facilitators of Maternal Health Care Utilization in Central Myanmar

Author

Milkowska-Shibata, Maja Aleksandra, primary, Aye, Thin Thin, additional, Yi, San Myint, additional, Oo, Khin Thein, additional, Khaing, Kyi, additional, Than, Marlar, additional, Win, Thinzar, additional, Myo, Su Yi, additional, Toe, Su Yi, additional, West, Heidi Sierra, additional, Ringstad, Kristin Melissa, additional, Galarza, Lizeth, additional, Meng, Can, additional, and Shibata, Tomoyuki, additional

Published
2020
Full Text
View/download PDF

163. The BEACHES Study: health effects and exposures from non-point source microbial contaminants in subtropical recreational marine waters

Author

Fleisher, Jay M, Fleming, Lora E, Solo-Gabriele, Helena M, Kish, Jonathan K, Sinigalliano, Christopher D, Plano, Lisa, Elmir, Samir M, Wang, John D, Withum, Kelly, Shibata, Tomoyuki, Gidley, Maribeth L, Abdelzaher, Amir, He, Guoqing, Ortega, Cristina, Zhu, Xiaofang, Wright, Mary, Hollenbeck, Julie, and Backer, Lorraine C

Published
2010
Full Text
View/download PDF

166. Endoscopic ultrasound‐guided needle‐based confocal laser endomicroscopy in gastrointestinal subepithelial lesions: Feasibility study

Author

Terada, Tsuyoshi, primary, Tahara, Tomomitsu, additional, Hashimoto, Senju, additional, Horiguchi, Noriyuki, additional, Funasaka, Kohei, additional, Nagasaka, Mitsuo, additional, Nakagawa, Yoshihito, additional, Shibata, Tomoyuki, additional, Yoshioka, Kentaro, additional, Tsukamoto, Tetsuya, additional, Kuroda, Makoto, additional, and Ohmiya, Naoki, additional

Published
2019
Full Text
View/download PDF

167. Lower LINE-1 methylation is associated with promoter hypermethylation and distinct molecular features in gastric cancer

Author

Tahara, Sayumi, primary, Tahara, Tomomitsu, additional, Horiguchi, Noriyuki, additional, Okubo, Masaaki, additional, Terada, Tsuyoshi, additional, Yoshida, Dai, additional, Funasaka, Kohei, additional, Nakagawa, Yoshihito, additional, Shibata, Tomoyuki, additional, Tsukamoto, Tetsuya, additional, and Ohmiya, Naoki, additional

Published
2019
Full Text
View/download PDF

168. Diagnostic utility of probe-based confocal laser endomicroscopy in superficial non-ampullary duodenal epithelial tumors

Author

Tahara, Tomomitsu, additional, Horiguchi, Noriyuki, additional, Terada, Tsuyoshi, additional, Yamada, Hyuga, additional, Yoshida, Dai, additional, Okubo, Masaaki, additional, Funasaka, Kohei, additional, Nagasaka, Mitsuo, additional, Nakagawa, Yoshihito, additional, Tsukamoto, Tetsuya, additional, Shibata, Tomoyuki, additional, Kuroda, Makoto, additional, and Ohmiya, Naoki, additional

Published
2019
Full Text
View/download PDF

172. In vivo characterization of abnormalities in small-bowel diseases using probe-based confocal laser endomicroscopy 1

Author

Ohmiya, Naoki, Horiguchi, Noriyuki, Tahara, Tomomitsu, Nagasaka, Mitsuo, Nakagawa, Yoshihito, Shibata, Tomoyuki, Tsukamoto, Tetsuya, and Kuroda, Makoto

Subjects
Original article
Abstract

Background and study aims Probe-based confocal laser endomicroscopy (pCLE) enables real-time optical biopsy. Little is known about pCLE imaging deep inside the small bowel, therefore the aim of this study was to determine its usefulness. Patients and methods Between April 2014 and January 2016, we performed 38 pCLE examinations during double-balloon enteroscopy with intravenous fluorescein in 37 patients with: tumors (n = 10), vascular disorders (n = 6), inflammatory diseases and drug injuries (n = 13), other disorders (n = 4), and normal findings (n = 4). We measured the calibers of capillary and lymphatic vessels at 15 different sites and compared the calibers between pCLE images and histopathology. We also compared pCLE findings with pathologic diagnosis. Results The inner diameters of capillary vessels beneath the epithelium and in the middle of villi were 16.2 ± 3.0 µm and 14.5 ± 3.1 µm, respectively, in the pCLE images, but these were not consistent with formalin-fixed paraffin-embedded histology. In tumors, larger capillary vessels were observed in aggressive malignant lymphoma and metastasis, and a “soccer ball-like pattern” constituting homogenous dark cells packed with polygonal, narrower capillary vessels was characteristic in pCLE images of a malignant lymphoma follicle. Hereditary hemorrhagic telangiectasia and angiodysplasia contained anastomosis of capillary vessels of different calibers. In IgA vasculitis, segmental capillary strictures were observed. Intestinal lymphangiectasia with protein-losing enteropathy contained a reticular network of lymphatic vessels and dilated lymphatic ducts accompanied by numerous cell gaps. pCLE findings corresponded to pathologic diagnosis in 32 examinations (91 %). Conclusions pCLE is useful for in vivo analysis of abnormalities of the capillary and lymphatic vessels and epithelium, and for diagnosis in various small-bowel diseases.

Published
2017

176. 島根県津和野地域の舞鶴帯から古原生代18.5億年花崗岩質岩体の発見とその意義

Author

Kimura, Kosuke, Hayasaka, Yasutaka, Shibata, Tomoyuki, Kawaguchi, Kenta, and Fujiwara, Hiroshi

Subjects
Zircon U-Pb age, Paleoproterozoic granitoid, Tsuwano area, Southwest Japan, orthogneiss, Northern zone of Maizuru Terrane, North China Craton
Abstract

島根県津和野地域の舞鶴帯北縁部から古原生代の花崗岩類と正片麻岩を見出した．この岩体は苦鉄質岩類を伴い，ペルム系の堆積岩類に挟まれた幅数百mの狭長な地帯にブロックの集合体として産する．ジルコンのU-Pb年代は，正片麻岩が1836±17Ma，トーナル岩-石英閃緑岩が1853±14Ma，花崗閃緑岩が415.2±2.5Maであった．古原生代のジルコンは2.8-2.1Gaの古いコアを持ち，北中国地塊由来と考えられる．デボン紀のものは年代から舞鶴-大江地域の舞鶴帯北帯西部岩体に対比され，岩相構成と産状から古原生代岩体も舞鶴帯北帯構成要素と考えられる．本岩体は，古い地質体ほど構造的上位に位置するという西南日本内帯のパイルナップ構造の一般則から外れ，ジュラ紀の付加体・変成岩と接する舞鶴帯北縁部に産することから，舞鶴帯北縁に沿う横ずれ断層によって異地性ブロックとして定置した可能性がある．, We report a newly discovered Paleoproterozoic granitoid at the northern margin of the Maizuru Terrane (Tsuwano area, southwestern Shimane Prefecture, SW Japan). The granitoid is associated with metadolerite and metagabbro, and appears as lenticular blocks within a narrow (150-300 m wide) zone. Orthogneiss and tonalite-quartz diorite from the granitoid yield zircon U‒Pb ages of 1836±17 Ma and 1853 ± 14 Ma, respectively. Younger U‒Pb ages of 415.2±2.5 Ma were obtained from a granodioritic lithology. The Paleoproterozoic zircon grains commonly contain inherited older (2800‒2100 Ma) cores. The Paleoproterozoic age of the granitoid body supports the suggestion that this part of the Maizuru Terrane includes exotic blocks that originated from the North China Craton. The younger (Early Devonian) granodiorite is possibly related to igneous rocks of similar age from the Maizuru‒Oe area (Northern Zone of the Maizuru Terrane). Based on the lithology and structural position of the Paleoproterozoic rocks, it is suggested that they are part of the Northern Zone. The recognition of a narrow zone of Paleoproterozoic rocks embedded in Permian strata is in contrast to the nappe structure in SW Japan, which typically contains older units at higher structural positions. We therefore suggest that the Paleoproterozoic blocks were displaced by strike-slip faulting along the northern boundary of the Maizuru Terrane., 本研究には，文部科学省の2013-～2015年度科学研究費補助金（課題番号 : 25400486）を使用した．

Published
2019

185. Syntheses and crystal structures of the cinchona alkaloid derivatives used as ligands in the osmium-catalyzed asymmetric dihydroxylation of olefins

Author

Amberg, Willi, Bennani, Youssef L., Chadha, Raj K., Crispino, Gerard A., Davis, William D., Hartung, Jens, Kyu-Sung Jeong, Ogino, Yasukazu, Shibata, Tomoyuki, and Sharpless, K. Barry

Subjects
Organic compounds -- Synthesis, Ligands -- Research, Quinine -- Usage, Quinidine -- Usage, Phthalates -- Usage, Diazo compounds -- Usage, Coal-tar products -- Usage, Olefins -- Research, Alcohols -- Research, Hydroxylation -- Methods, Chirality -- Methods, Biological sciences, Chemistry
Abstract

An improved wayof preparing asymmetric dihydroxylation (AD) ligands involves the reaction of dihydroquinine (DHQ) or dihydroquinidine (DHQD) with 1,4-dichlorophthalazine ((PHAL)Cl2) in the presence of potassium carbonate and hydroxide. (DHQ)2-PHAL and (DHQD)2-PHAL are thus produced in 68-88% yields and >98% purity. The phenanthrene analogues, DHQ-PHN and DHQD-PHN, are obtained in 70-73% yields viaan Ullman-type coupling between sodium alkoxide and 9-iodophenanthrene. The four phthalazines are so far the most effective ligands in the osmium-catalyzedAD of four of the six olefin types.

Published
1993

186. Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1 in the gastric epithelium

Author

Nomura Tomoe, Tahara Tomomitsu, Shiroeda Hisakazu, Minato Takahiro, Matsue Yasuhiro, Hayashi Ranji, Matsunaga Kazuhiro, Otsuka Toshimi, Nakamura Masakatsu, Toshikuni Nobuyuki, Shibata Tomoyuki, and Arisawa Tomiyasu

Subjects
HRH2, Genetic polymorphism, Aberrant DNA methylation, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Background Aberrant methylation patterns in CpG island are known to be influential in gene silencing. Histamine plays important physiological roles in the upper gastrointestinal tract and acts via the H2 receptor. We report an investigation into the effect of HRH2 promoter polymorphism (rs2607474 G > A) on the methylation of DAPK and CDH1. Methods Non cancerous gastric mucosa samples were obtained from 115 subjects with gastric cancer (GC) and 412 non-cancer subjects (non-GC). Methylation status of genes was determined by MSP. The genotyping of rs2607474 was performed by PCR-SSCP. Results Methylation of DAPK and CDH1 was observed in 296 and 246 subjects, respectively. The frequency of CDH1 methylation in the subjects with GC was significantly lower in cancer lesion than in non cancerous mucosa, whereas that of DAPK methylation was not different. The allelic distribution of rs2607474 was 401GG, 119GA and 7AA. The GG homozygote was associated with a significantly increased risk for methylation of both DAPK and CDH1 (p DAPK and CDH1 methylation. However, this genotype did not show an increased risk for the development of methylation of both genes in patients with GC. In H. pylori negative subjects, GG homozygote showed an increased risk for the methylation of both DAPK and CDH1 (p = 0.0074 and p = 0.0016, respectively), whereas this genotype was associated with an increased risk for the development of DAPK methylation in H. pylori positive subjects (p = 0.0018). In addition, in subjects older than 60 years of age, atrophy and metaplasia scores were significantly higher in the GG homozygote (p = 0.011 and p = 0.039, respectively) and a significant correlation was observed between age and atrophy or metaplasia. Conclusions Our results suggest that rs2607474 GG homozygote confers a significantly increased risk for age- and inflammation-related DAPK and CDH1 methylation.

Published
2013
Full Text
View/download PDF

187. Influence of IL17A polymorphisms on the aberrant methylation of DAPK and CDH1 in non-cancerous gastric mucosa

Author

Arisawa Tomiyasu, Tahara Tomomitsu, Tsutsumi Mikihiro, and Shibata Tomoyuki

Subjects
IL17A, Aberrant DNA methylation, DAPK, CDH1, Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background CpG island aberrant methylation is shown to be an important mechanism in gene silencing. The important role of IL-17 in inflammatory response to H. pylori colonization has been indicated. We investigated the influence of IL17A polymorphisms, -197 G > A (rs2275913) and *1249 C > T (rs3748067), on the methylation of DAPK and CDH1. Methods Gastric mucosal samples were obtained from 401 subjects without malignancies. Methylation status of gene was determined by MSP. The genotyping of IL17A was performed by PCR-SSCP. Results Methylations of DAPK and CDH1 were seen in 196 and 149 of all 401 subjects, respectively. Overall, *1249 T carrier was associated with a decreased risk for DAPK methylation, whereas -197 G > A was not. In the subjects older than 60 years old, *1249 T carrier was more strongly associated with gene methylation and -197 A carrier tended to be associated with an increased risk for CDH1 methylation. When evaluating by inflammation promoting haplotype (-197 mutant carrier with *1249 homozygote), this haplotype had a more strongly increased risk for both DAPK and CDH1 methylations in comparatively older subjects. Both atrophy and metaplasia scores were significantly increased with age in -197 A carrier or *1249 CC homozygote, whereas were not in -197 GG homozygote or *1249 T carrier. PG I/II ratio was more significantly decreased in -197 A carrier than in GG homozygote under influence of H. pylori infection. Conclusions In -197 A allele carrier with *1249 CC homozygote, the methylations of both DAPK and CDH1 may be increased gradually, but more rapidly than the other genotypes, with age and altered gastric mucosal structure induced by H. pylori infection.

Published
2012
Full Text
View/download PDF

188. Correlation between magnifying narrow band imaging and histopathology in gastric protruding/or polypoid lesions: a pilot feasibility trial

Author

Omori Takafumi, Kamiya Yoshio, Tahara Tomomitsu, Shibata Tomoyuki, Nakamura Masakatsu, Yonemura Joh, Okubo Masaaki, Yoshioka Daisuke, Ishizuka Takamitsu, Maruyama Naoko, Kamano Toshiaki, Fujita Hiroshi, Nakagawa Yoshihito, Nagasaka Mitsuo, Iwata Masami, Arisawa Tomiyasu, and Hirata Ichiro

Subjects
NBI, Stomach, Magnifying endoscopy, Polypoid lesions, Gastric cancer, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Background Several study showed usefulness of microscopic capillaries, seen by magnifying narrow band imaging (NBI) endoscopy for predicting histopathology among superficial depressed or flat elevated gastric neoplasia (GN). Here we assessed the diagnostic efficacy of magnifying NBI for predicting histopathology among gastric protruding/or polypoid lesions. Methods Using endoscopic pictures of magnifying NBI from 95 protruding/or polypoid lesions (19 fundic gland polyps: FGP, 47 hyperplastic polyps: HP, and 29 GN), fine mucosal patterns were classified into four categories: small round, prolonged, villous or ridge, and unclear patterns, and micro vascular patterns were classified into five categories: honey comb, dense vascular, fine net work, core vascular, and unclear patterns. Results Most suggestive micro vascular patterns for predicting FGP, and HP were honeycomb (sensitivity 94.7%, specificity 97.4%), and dense vascular patterns (sensitivity 93.6%, specificity 91.6%), respectively. Fine net work, core vascular, and unclear patterns presented higher specificity (97%, 100%, and 100%) for predicting GN, and diagnostic efficacy of combined of those patterns was favorable (sensitivity 86.2%, specificity 97.0%). Conclusion Micro vascular patterns by using magnifying NBI provides meaningful information for predicting the histopathology of gastric protruding/or polypoid lesions.

Published
2012
Full Text
View/download PDF

189. Gastric Mucosal Microarchitectures Associated with Irreversibility with Helicobacter pylori Eradication and Downregulation of Micro RNA (miR)-124a

Author

Tahara, Tomomitsu, primary, Tahara, Sayumi, additional, Horiguchi, Noriyuki, additional, Kawamura, Tomohiko, additional, Okubo, Masaaki, additional, Nagasaka, Mitsuo, additional, Nakagawa, Yoshihito, additional, Shibata, Tomoyuki, additional, Urano, Makoto, additional, Tsukamoto, Tetsuya, additional, Kuroda, Makoto, additional, and Ohmiya, Naoki, additional

Published
2019
Full Text
View/download PDF

190. Prostate Stem Cell Antigen Gene Polymorphism Is Associated with H. pylori–related Promoter DNA Methylation in Nonneoplastic Gastric Epithelium

Author

Tahara, Tomomitsu, primary, Tahara, Sayumi, additional, Horiguchi, Noriyuki, additional, Kato, Takema, additional, Shinkai, Yasuko, additional, Okubo, Masaaki, additional, Terada, Tsuyoshi, additional, Yoshida, Dai, additional, Funasaka, Kohei, additional, Nagasaka, Mitsuo, additional, Nakagawa, Yoshihito, additional, Kurahashi, Hiroki, additional, Shibata, Tomoyuki, additional, Tsukamoto, Tetsuya, additional, and Ohmiya, Naoki, additional

Published
2019
Full Text
View/download PDF

194. Real-time diagnostic yield of white light endoscopy, chromoendoscopy and magnifying endoscopy with narrow band imaging in the undiagnosed gastric lesions after Helicobacter pylori eradication

Author

Tahara, Tomomitsu, primary, Horiguchi, Noriyuki, additional, Terada, Tsuyoshi, additional, Yoshida, Dai, additional, Okubo, Masaaki, additional, Funasaka, Kohei, additional, Nakagawa, Yoshihito, additional, Shibata, Tomoyuki, additional, and Ohmiya, Naoki, additional

Published
2019
Full Text
View/download PDF

198. Mo1324 REAL-TIME DIAGNOSTIC YIELD OF WHITE LIGHT ENDOSCOPY, CHROMOENDOSCOPY AND MAGNIFYING ENDOSCOPY WITH NARROW BAND IMAGING IN THE UNDIAGNOSED GASTRIC LESIONS AFTER HELICOBACTER PYLORI ERADICATION

Author

Tahara, Tomomitsu, primary, Horiguchi, Noriyuki, additional, Terada, Tsuyoshi, additional, Yoshida, Dai, additional, Okubo, Masaaki, additional, Funasaka, Kohei, additional, Nakagawa, Yoshihito, additional, Shibata, Tomoyuki, additional, and Ohmiya, Naoki, additional

Published
2019
Full Text
View/download PDF

199. Su1072 – Helicobacter Pylori-Related Dna Methylation in Primary Gastric Cancer Significantly Correlates with Cancerspecific Dna Methylation and Distinct Clinicopathological Features

Author

Tahara, Sayumi, primary, Tahara, Tomomitsu, additional, Horiguchi, Noriyuki, additional, Okubo, Masaaki, additional, Terada, Tsuyoshi, additional, Yoshida, Dai, additional, Funasaka, Kohei, additional, Nakagawa, Yoshihito, additional, Shibata, Tomoyuki, additional, Tsukamoto, Tetsuya, additional, and Ohmiya, Naoki, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results