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151. Optimal multifrequency weighting for CMB lensing

Author: Sailer, Noah, Schaan, Emmanuel, Ferraro, Simone, Darwish, Omar, and Sherwin, Blake
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Extragalactic foregrounds in Cosmic Microwave Background (CMB) temperature maps lead to significant biases in CMB lensing reconstruction if not properly accounted for. Combinations of multi-frequency data have been used to minimize the overall map variance (internal linear combination, or ILC), or specifically null a given foreground, but these are not tailored to CMB lensing. In this paper, we derive an optimal multi-frequency combination to jointly minimize CMB lensing noise and bias. We focus on the standard lensing quadratic estimator, as well as the "shear-only" and source-hardened estimators, whose responses to foregrounds differ. We show that an optimal multi-frequency combination is a compromise between the ILC and joint deprojection, which nulls the thermal Sunyaev-Zel'dovich (tSZ) and Cosmic Infrared Background (CIB) contributions. In particular, for a Simons Observatory-like experiment with $\ell_{\text{max},T}=3000$, we find that profile hardening alone (with the standard ILC) reduces the bias to the lensing power amplitude by $40\%$, at a $20\%$ cost in noise, while the bias to the cross-correlation with a LSST-like sample is reduced by nearly an order of magnitude at a $10\%$ noise cost, relative to the standard quadratic estimator. With a small amount of joint deprojection the bias to the profile hardened estimator can be further reduced to less than half the statistical uncertainty on the respective amplitudes, at a $20\%$ and $5\%$ noise cost for the auto- and cross-correlation respectively, relative to the profile hardened estimator with the standard ILC weights. Finally, we explore possible improvements with more aggressive masking and varying $\ell_{\text{max,}T}$., Comment: published in PRD
Published: 2021
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152. LEGEND-1000 Preconceptual Design Report

Author: LEGEND Collaboration, Abgrall, N., Abt, I., Agostini, M., Alexander, A., Andreoiu, C., Araujo, G. R., Avignone III, F. T., Bae, W., Bakalyarov, A., Balata, M., Bantel, M., Barabanov, I., Barabash, A. S., Barbeau, P. S., Barton, C. J., Barton, P. J., Baudis, L., Bauer, C., Bernieri, E., Bezrukov, L., Bhimani, K. H., Biancacci, V., Blalock, E., Bolozdynya, A., Borden, S., Bos, B., Bossio, E., Boston, A., Bothe, V., Bouabid, R., Boyd, S., Brugnera, R., Burlac, N., Busch, M., Caldwell, A., Caldwell, T. S., Carney, R., Cattadori, C., Chan, Y. -D., Chernogorov, A., Christofferson, C. D., Chu, P. -H., Clark, M., Cohen, T., Combs, D., Comellato, T., Cooper, R. J., Costa, I. A., D'Andrea, V., Detwiler, J. A., Di Giacinto, A., Di Marco, N., Dobson, J., Drobizhev, A., Durand, M. R., Edzards, F., Efremenko, Yu., Elliott, S. R., Engelhardt, A., Fajt, L., Faud, N., Febbraro, M. T., Ferella, F., Fields, D. E., Fischer, F., Fomina, M., Fox, H., Franchi, J., Gala, R., Galindo-Uribarri, A., Gangapshev, A., Garfagnini, A., Geraci, A., Gilbert, C., Gold, M., Gooch, C., Gradwohl, K. P., Green, M. P., Grinyer, G. F., Grobov, A., Gruszko, J., Guinn, I., Guiseppe, V. E., Gurentsov, V., Gurov, Y., Gusev, K., Hacket, B., Hagemann, F., Hakenmüeller, J., Haranczyk, M., Hauertmann, L., Haufe, C. R., Hayward, C., Heffron, B., Henkes, F., Henning, R., Aguilar, D. Hervas, Hinton, J., Hodak, R., Hoffmann, H., Hofmann, W., Hostiuc, A., Huang, J., Hult, M., Mirza, M. Ibrahim, Jochum, J., Jones, R., Judson, D., Junker, M., Kaizer, J., Kazalov, V., Kermaïdic, Y., Khushbakht, H., Kidd, M., Kihm, T., Kilgus, K., Kim, I., Klimenko, A., Knöpfle, K. T., Kochetov, O., Konovalov, S. I., Kontul, I., Kool, K., Kormos, L. L., Kornoukhov, V. N., Korosec, M., Krause, P., Kuzminov, V. V., López-Castaño, J. M., Lang, K., Laubenstein, M., León, E., Lehnert, B., Leonhardt, A., Li, A., Lindner, M., Lippi, I., Liu, X., Liu, J., Loomba, D., Lubashevskiy, A., Lubsandorzhiev, B., Lusardi, N., Müller, Y., Macko, M., Macolino, C., Majorovits, B., Mamedov, F., Maneschg, W., Manzanillas, L., Marshall, G., Martin, R. D., Martin, E. L., Massarczyk, R., Mei, D., Meijer, S. J., Mertens, S., Misiaszek, M., Mondragon, E., Morella, M., Morgan, B., Mroz, T., Muenstermann, D., Nave, C. J., Nemchenok, I., Neuberger, M., Oli, T. K., Gann, G. Orebi, Othman, G., Palušova, V., Panth, R., Papp, L., Paudel, L. S., Pelczar, K., Perez, J. Perez, Pertoldi, L., Pettus, W., Piseri, P., Poon, A. W. P., Povinec, P., Pullia, A., Radford, D. C., Ramachers, Y. A., Ransom, C., Rauscher, L., Redchuk, M., Reine, A. L., Riboldi, S., Rielage, K., Rozov, S., Rukhadze, E., Rumyantseva, N., Runge, J., Ruof, N. W., Saakyan, R., Sailer, S., Salamanna, G., Salamida, F., Salvat, D. J., Sandukovsky, V., Schönert, S., Schültz, A., Schütt, M., Schaper, D. C., Schreiner, J., Schulz, O., Schuster, M., Schwarz, M., Schwingenheuer, B., Selivanenko, O., Shafiee, M., Shevchik, E., Shirchenko, M., Shitov, Y., Simgen, H., Simkovic, F., Skorokhvatov, M., Slavickova, M., Smolek, K., Smolnikov, A., Solomon, J. A., Song, G., Starosta, K., Stekl, I., Stommel, M., Stukov, D., Sumathi, R. R., Sweigart, D. A., Szczepaniec, K., Taffarello, L., Tagnani, D., Tayloe, R., Tedeschi, D., Turqueti, M., Varner, R. L., Vasilyev, S., Veresnikova, A., Vetter, K., Vignoli, C., Vogl, C., von Sturm, K., Waters, D., Waters, J. C., Wei, W., Wiesinger, C., Wilkerson, J. F., Willers, M., Wiseman, C., Wojcik, M., Wu, V. H. -S., Xu, W., Yakushev, E., Ye, T., Yu, C. -H., Yumatov, V., Zaretski, N., Zeman, J., Zhitnikov, I., Zinatulina, D., Zschocke, A. -K., Zsigmond, A. J., Zuber, K., and Zuzel, G.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: We propose the construction of LEGEND-1000, the ton-scale Large Enriched Germanium Experiment for Neutrinoless $\beta \beta$ Decay. This international experiment is designed to answer one of the highest priority questions in fundamental physics. It consists of 1000 kg of Ge detectors enriched to more than 90% in the $^{76}$Ge isotope operated in a liquid argon active shield at a deep underground laboratory. By combining the lowest background levels with the best energy resolution in the field, LEGEND-1000 will perform a quasi-background-free search and can make an unambiguous discovery of neutrinoless double-beta decay with just a handful of counts at the decay $Q$ value. The experiment is designed to probe this decay with a 99.7%-CL discovery sensitivity in the $^{76}$Ge half-life of $1.3\times10^{28}$ years, corresponding to an effective Majorana mass upper limit in the range of 9-21 meV, to cover the inverted-ordering neutrino mass scale with 10 yr of live time.
Published: 2021

153. A Security Cost Modelling Framework for Cyber-Physical Systems

Author: Ivkic, Igor, Sailer, Patrizia, Gouglidis, Antonios, Mauthe, Andreas, and Tauber, Markus
Subjects: Computer Science - Cryptography and Security, Computer Science - Performance
Abstract: Cyber-Physical Systems (CPS) are formed through interconnected components capable of computation, communication, sensing and changing the physical world. The development of these systems poses a significant challenge since they have to be designed in a way to ensure cyber-security without impacting their performance. This article presents the Security Cost Modelling Framework (SCMF) and shows supported by an experimental study how it can be used to measure, normalise and aggregate the overall performance of a CPS. Unlike previous studies, our approach uses different metrics to measure the overall performance of a CPS and provides a methodology for normalising the measurement results of different units to a common Cost Unit. Moreover, we show how the Security Costs can be extracted from the overall performance measurements which allows to quantify the overhead imposed by performing security-related tasks. Furthermore, we describe the architecture of our experimental testbed and demonstrate the applicability of SCMF in an experimental study. Our results show that measuring the overall performance and extracting the security costs using SCMF can serve as basis to redesign interactions to achieve the same overall goal at less costs.
Published: 2021
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154. Analysing Design Approaches for the Power Consumption in Cyber-Physical Systems

Author: Sailer, Patrizia, Ivkic, Igor, Tauber, Markus, Mauthe, Andreas, and Gouglidis, Antonios
Subjects: Computer Science - Other Computer Science
Abstract: The importance of Cyber Physical Systems (CPS) and Internet of Things (IoT) applications is constantly increasing, especially in the context of Industry 4.0. Architectural decisions are crucial not just for performance, security and resilience reasons but also regarding costs and resource usage. In this paper we analyse two of the fundamental approaches to design control loops (i.e. time-driven and event-driven), show how they can be realised and evaluate their power requirements. Through this the design criteria can be extended also considering the optimization of energy related aspects., Comment: IEEE Link: https://ieeexplore.ieee.org/document/9464065
Published: 2021

155. TeV emission of Galactic plane sources with HAWC and H.E.S.S

Author: Abdalla, H., Aharonian, F., Benkhali, F. Ait, Angüner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Martins, V. Barbosa, Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., de Lavergne, M. de Bony, Breuhaus, M., Brose, R., Brun, F., Brun, P., Bryan, M., Büchele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Chand, T., Chandra, S., Chen, A., Cotter, G., Curyło, M., Mbarubucyeye, J. Damascene, Davids, I. D., Davies, J., Deil, C., Devin, J., Dirson, L., Djannati-Ataï, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dreyer, L., Duffy, C., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J. -P., Feijen, K., Fegan, S., Fiasson, A., de Clairfontaine, G. Fichet, Fontaine, G., Funk, S., Füßling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Hörbe, M., Horns, D., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jung-Richardt, I., Kasai, E., Kastendieck, M. A., Katarzyński, K., Katz, U., Khangulyan, D., Khélifi, B., Klepser, S., Kluźniak, W., Komin, Nu., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Leuschner, F., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Martí-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A. M. W., Moderski, R., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., de Naurois, M., Ndiyavala, H., Niemiec, J., Oakes, L., Brien, P. O, Odaka, H., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Panter, M., Parsons, R. D., Peron, G., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Noel, A. Priyana, Prokhorov, D. A., Prokoph, H., Pühlhofer, G., Punch, M., Quirrenbach, A., Raab, S., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Sahakian, V., Sailer, S., Salzmann, H., Sanchez, D. A., Santangelo, A., Sasaki, M., Schäfer, J., Schüssler, F., Schutte, H. M., Schwanke, U., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shapopi, J. N. S., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, Ł., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Thiersen, J. H. E., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Völk, H. J., Wadiasingh, Z., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Yu Wun, Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zmija, A., Zorn, J., Zouari, S., Żywucka, N., Albert, A., Alfaro, R., Alvarez, C., Arteaga-Velázquez, J. C., Arunbabu, K. P., Rojas, D. Avila, Belmont-Moreno, E., BenZvi, S. Y., Brisbois, C., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Cotti, U., Cotzomi, J., de León, S. Coutiño, De la Fuente, E., de León, C., Hernandez, R. Diaz, Díaz-Vélez, J. C., Dingus, B. L., DuVernois, M. A., Durocher, M., Ellsworth, R. W., Engel, K., Espinoza, C., Fan, K. L., Alonso, M. Fernández, Fraija, N., Galván-Gámez, A., Garcia, D., García-González, J. A., Garfias, F., Giacinti, G., González, M. M., Goodman, J. A., Harding, J. P., Hernandez, S., Hona, B., Huang, D., Hueyotl-Zahuantitla, F., Hüntemeyer, P., Iriarte, A., Jardin-Blicq, A., Joshi, V., Kieda, D., Lee, W. H., Vargas, H. León, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., López-Coto, R., Malone, K., Martinez, O., Martinez-Castellanos, I., Martínez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Morales-Soto, J. A., Moreno, E., Mostafá, M., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Omodei, N., Peisker, A., Araujo, Y. Pérez, Pérez-Pérez, E. G., Rho, C. D., Rosa-González, D., Ruiz-Velasco, E., Greus, F. Salesa, Sandoval, A., Schneider, M., Schoorlemmer, H., Serna-Franco, J., Smith, A. J., Springer, R. W., Surajbali, P., Tollefson, K., Torres, I., Torres-Escobedo, R., Turner, R., Ureña-Mena, F., Villaseñor, L., Weisgarber, T., Willox, E., and Zhou, H.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The High Altitude Water Cherenkov (HAWC) observatory and the High Energy Stereoscopic System (H.E.S.S.) are two leading instruments in the ground-based very-high-energy gamma-ray domain. HAWC employs the water Cherenkov detection (WCD) technique, while H.E.S.S. is an array of Imaging Atmospheric Cherenkov Telescopes (IACTs). The two facilities therefore differ in multiple aspects, including their observation strategy, the size of their field of view and their angular resolution, leading to different analysis approaches. Until now, it has been unclear if the results of observations by both types of instruments are consistent: several of the recently discovered HAWC sources have been followed up by IACTs, resulting in a confirmed detection only in a minority of cases. With this paper, we go further and try to resolve the tensions between previous results by performing a new analysis of the H.E.S.S. Galactic plane survey data, applying an analysis technique comparable between H.E.S.S. and HAWC. Events above 1 TeV are selected for both datasets, the point spread function of H.E.S.S. is broadened to approach that of HAWC, and a similar background estimation method is used. This is the first detailed comparison of the Galactic plane observed by both instruments. H.E.S.S. can confirm the gamma-ray emission of four HAWC sources among seven previously undetected by IACTs, while the three others have measured fluxes below the sensitivity of the H.E.S.S. dataset. Remaining differences in the overall gamma-ray flux can be explained by the systematic uncertainties. Therefore, we confirm a consistent view of the gamma-ray sky between WCD and IACT techniques.
Published: 2021
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156. Pulmonary artery pseudoaneurysms: a single-center experience of endovascular occlusion

Author: Adam Fish, Anne Sailer, Jeffrey Pollak, and Todd Schlachter
Subjects: Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Abstract The technique and outcomes of pulmonary artery pseudoaneurysm (PAP) embolization was retrospectively evaluated in 13 patients undergoing 14 PAP embolizations between January 2014 and September 2023. The etiology of the PAP was iatrogenic (4/13), tumor (3/13), chronic lung (2/13), idiopathic (2/13) and mycotic (2/13). Clinical presentation was massive hemorrhage (6/13), incidental (4/13), and non-massive hemoptysis (3/13). The average PAP size was 13.5 mm. Coil embolization of the PAP sac was performed in all but two extenuating cases (11/13). Follow-up of 12 patients over an average 5.3-months showed persistent occlusion in all cases. There were no major adverse events attributed to the embolization. Five out of ten patients with procedures performed at least one year before this study were noted to be deceased after an average seven-month time. PAPs of various etiologies may be safely and effectively treated by occluding the aneurysm inflow, outflow, and sac.
Published: 2023
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157. Use of professional home care in persons with spinal cord injury in Switzerland: a cross-sectional study

Author: Aylin Wagner, Mirjam Brach, Anke Scheel-Sailer, Manuela Friedli, Margret Hund-Georgiadis, Xavier Jordan, Martin Schubert, and Armin Gemperli
Subjects: Home care, Spinal cord injury, Informal care, Cross-sectional survey, Public aspects of medicine, RA1-1270
Abstract: Abstract Background Persons with spinal cord injury (SCI) living in the community often require care. The boundaries between professional home care and informal care are blurred, and it is unclear who the typical user of home care is. The objective of this study was to describe the characteristics of persons with SCI using professional home care in Switzerland, determine the frequency of home care visits, and investigate the association of sociodemographic factors, SCI-specific characteristics, secondary health conditions, and functional independence with the use of home care. Methods We used cross-sectional data from the 2017 community survey of the Swiss Spinal Cord Injury Cohort Study (SwiSCI). Out of 3,959 eligible individuals 1294 completed the questionnaire and were included in the analysis (response rate 33%). Using descriptive statistics, differences between home care users and non-users as well as the frequency of home care visits were investigated. The association between sociodemographic factors, SCI-specific characteristics, secondary health conditions, functional independence and the use of home care was analyzed using multivariable logistic regression. Multiple imputation was used to account for missing data. Results Of 1,294 participants, 280 (22%) used professional home care. The median weekly professional home care duration was 6 h (Q1 = 2, Q3 = 12). More home care was used in persons with lower functional independence (Odds ratio (OR) 0.30 per 10 unit decrease in the Spinal Cord Independence Measure, 95%-Confidence interval (CI) 0.24–0.37), fewer secondary health conditions (OR 0.96 per unit Spinal Cord Injury Secondary Conditions Scale, 95%-CI 0.94–0.99), tetraplegia (OR 2.77, 95%-CI 1.92–4.00), women (OR 2.42, 95%-CI 1.70–3.43), higher age (OR 1.22 per 10 years increase, 95%-CI 1.06–1.39), living alone (OR 2.48, 95%-CI 1.53–4.03), and those receiving support from an informal caregiver (OR 1.88, 95%-CI 1.27–2.77). Conclusions This is the first study to examine the use of professional home care from the perspective of persons with SCI in Switzerland. Lower functional independence strongly predicts increased home care use. The findings showed that professional home care complements informal care and is more likely to be used by individuals with SCI who live alone, have tetraplegia, and are female.
Published: 2023
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158. Pharmacometrics enhanced Bayesian borrowing approach to improve clinical trial efficiency: Case of empagliflozin in type 2 diabetes

Author: Lucie Fayette, Martin Oliver Sailer, and Alejandro Perez‐Pitarch
Subjects: Therapeutics. Pharmacology, RM1-950
Abstract: Abstract We report use of a pharmacometrics enhanced Bayesian borrowing (PEBB) approach to leverage historical clinical trial data on a drug product to build models, project the outcome of future clinical trials, and borrow information from these projections to improve the efficiency of future target trials. This design takes a two‐stage approach. First, a design phase is performed before target trial data are available to determine the operating characteristics and an appropriate tuning parameter that will be used in the subsequent analysis phase of a chosen target trial. Second, once the target trial data are available, the analysis phase is performed with the determined tuning parameter. This step is where borrowing is applied from these projections to inform the results for the target trial. To illustrate how a PEBB could improve the efficiency of clinical trials, we apply our design to trials with empagliflozin for treating patients with type 2 diabetes. We performed a retrospective evaluation applying the method to a phase III target trial and a hypothetical smaller trial. The type I error could be kept below 10% while increasing the trial power and effective sample size. Our findings suggest that a PEBB has the potential to increase the power of clinical trials, while controlling for type I error, by leveraging the information from previous trials through population pharmacokinetic/pharmacodynamic modeling and simulation.
Published: 2023
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159. Universal DNA methylation age across mammalian tissues

Author: Lu, A. T., Fei, Z., Haghani, A., Robeck, T. R., Zoller, J. A., Li, C. Z., Lowe, R., Yan, Q., Zhang, J., Vu, H., Ablaeva, J., Acosta-Rodriguez, V. A., Adams, D. M., Almunia, J., Aloysius, A., Ardehali, R., Arneson, A., Baker, C. S., Banks, G., Belov, K., Bennett, N. C., Black, P., Blumstein, D. T., Bors, E. K., Breeze, C. E., Brooke, R. T., Brown, J. L., Carter, G. G., Caulton, A., Cavin, J. M., Chakrabarti, L., Chatzistamou, I., Chen, H., Cheng, K., Chiavellini, P., Choi, O. W., Clarke, S. M., Cooper, L. N., Cossette, M. L., Day, J., DeYoung, J., DiRocco, S., Dold, C., Ehmke, E. E., Emmons, C. K., Emmrich, S., Erbay, E., Erlacher-Reid, C., Faulkes, C. G., Ferguson, S. H., Finno, C. J., Flower, J. E., Gaillard, J. M., Garde, E., Gerber, L., Gladyshev, V. N., Gorbunova, V., Goya, R. G., Grant, M. J., Green, C. B., Hales, E. N., Hanson, M. B., Hart, D. W., Haulena, M., Herrick, K., Hogan, A. N., Hogg, C. J., Hore, T. A., Huang, T., Izpisua Belmonte, J. C., Jasinska, A. J., Jones, G., Jourdain, E., Kashpur, O., Katcher, H., Katsumata, E., Kaza, V., Kiaris, H., Kobor, M. S., Kordowitzki, P., Koski, W. R., Krützen, M., Kwon, S. B., Larison, B., Lee, S. G., Lehmann, M., Lemaitre, J. F., Levine, A. J., Li, C., Li, X., Lim, A. R., Lin, D. T. S., Lindemann, D. M., Little, T. J., Macoretta, N., Maddox, D., Matkin, C. O., Mattison, J. A., McClure, M., Mergl, J., Meudt, J. J., Montano, G. A., Mozhui, K., Munshi-South, J., Naderi, A., Nagy, M., Narayan, P., Nathanielsz, P. W., Nguyen, N. B., Niehrs, C., O’Brien, J. K., O’Tierney Ginn, P., Odom, D. T., Ophir, A. G., Osborn, S., Ostrander, E. A., Parsons, K. M., Paul, K. C., Pellegrini, M., Peters, K. J., Pedersen, A. B., Petersen, J. L., Pietersen, D. W., Pinho, G. M., Plassais, J., Poganik, J. R., Prado, N. A., Reddy, P., Rey, B., Ritz, B. R., Robbins, J., Rodriguez, M., Russell, J., Rydkina, E., Sailer, L. L., Salmon, A. B., Sanghavi, A., Schachtschneider, K. M., Schmitt, D., Schmitt, T., Schomacher, L., Schook, L. B., Sears, K. E., Seifert, A. W., Seluanov, A., Shafer, A. B. A., Shanmuganayagam, D., Shindyapina, A. V., Simmons, M., Singh, K., Sinha, I., Slone, J., Snell, R. G., Soltanmaohammadi, E., Spangler, M. L., Spriggs, M. C., Staggs, L., Stedman, N., Steinman, K. J., Stewart, D. T., Sugrue, V. J., Szladovits, B., Takahashi, J. S., Takasugi, M., Teeling, E. C., Thompson, M. J., Van Bonn, B., Vernes, S. C., Villar, D., Vinters, H. V., Wallingford, M. C., Wang, N., Wayne, R. K., Wilkinson, G. S., Williams, C. K., Williams, R. W., Yang, X. W., Yao, M., Young, B. G., Zhang, B., Zhang, Z., Zhao, P., Zhao, Y., Zhou, W., Zimmermann, J., Ernst, J., Raj, K., and Horvath, S.
Published: 2023
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160. Is analytical tax research alive and kicking? Insights from 2000 until 2022

Author: Niemann, Rainer and Sailer, Mariana
Published: 2023
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161. Do taxes explain why firms rarely use performance-based malus contracts?

Author: Niemann, Rainer and Sailer, Mariana
Published: 2024
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162. Learning activities in technology-enhanced learning: A systematic review of meta-analyses and second-order meta-analysis in higher education

Author: Sailer, Michael, Maier, Rebecca, Berger, Sonja, Kastorff, Tamara, and Stegmann, Karsten
Published: 2024
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163. Routine action networks: An architectural study of spatial layouts and performativity in outpatient clinics

Author: Sailer, Kerstin
Published: 2024
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164. NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo

Author: Namoto, Kenji, Baader, Clara, Orsini, Vanessa, Landshammer, Alexandro, Breuer, Eva, Dinh, Kieu Trinh, Ungricht, Rosemarie, Pikiolek, Monika, Laurent, Stephane, Lu, Bo, Aebi, Alexandra, Schönberger, Katharina, Vangrevelinghe, Eric, Evrova, Olivera, Sun, Tianliang, Annunziato, Stefano, Lachal, Julie, Redmond, Emily, Wang, Louis, Wetzel, Kristie, Capodieci, Paola, Turner, Jonathan, Schutzius, Gabi, Unterreiner, Vincent, Trunzer, Markus, Buschmann, Nicole, Behnke, Dirk, Machauer, Rainer, Scheufler, Clemens, Parker, Christian N., Ferro, Magali, Grevot, Armelle, Beyerbach, Armin, Lu, Wei-Yu, Forbes, Stuart J., Wagner, Jürgen, Bouwmeester, Tewis, Liu, Jun, Sohal, Bindi, Sahambi, Sukhdeep, Greenbaum, Linda E., Lohmann, Felix, Hoppe, Philipp, Cong, Feng, Sailer, Andreas W., Ruffner, Heinz, Glatthar, Ralf, Humar, Bostjan, Clavien, Pierre-Alain, Dill, Michael T., George, Elizabeth, Maibaum, Jürgen, Liberali, Prisca, and Tchorz, Jan S.
Published: 2024
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165. Cosmology at high redshift -- a probe of fundamental physics

Author: Sailer, Noah, Castorina, Emanuele, Ferraro, Simone, and White, Martin
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: An observational program focused on the high redshift ($2
Published: 2021
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166. Evidence of 100 TeV $\gamma$-ray emission from HESS J1702-420: A new PeVatron candidate

Author: Abdalla, H., Aharonian, F., Benkhali, F. Ait, Angüner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Martins, V. Barbosa, Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., de Lavergne, M. de Bony, Breuhaus, M., Brun, F., Brun, P., Bryan, M., Büchele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Casanova, S., Chand, T., Chandra, S., Chen, A., Cotter, G., Curyło, M., Mbarubucyeye, J. Damascene, Davids, I. D., Davies, J., Deil, C., Devin, J., Dirson, L., Djannati-Atai, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dreyer, L., Duffy, C., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J. -P., Feijen, K., Fegan, S., Fiasson, A., de Clairfontaine, G. Fichet, Fontaine, G., Funk, S., Füßling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Grondin, M. -H., Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Hörbe, M., Horns, D., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kasai, E., Kastendieck, M. A., Katarzynski, K., Katz, U., Khangulyan, D., Khélifi, B., Klepser, S., Kluźniak, W., Komin, Nu., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Leuschner, F., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Martí-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., de Naurois, M., Ndiyavala, H., Niemiec, J., Oakes, L., O'Brien, P., Odaka, H., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Panter, M., Parsons, R. D., Peron, G., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Noel, A. Priyana, Prokhorov, D. A., Prokoph, H., Pühlhofer, G., Punch, M., Quirrenbach, A., Raab, S., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Salzmann, H., Sanchez, D. A., Santangelo, A., Sasaki, M., Scalici, M., Schäfer, J., Schüssler, F., Schutte, H. M., Schwanke, U., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shapopi, J. N. S., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, L., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Thiersen, J. H. E., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Völk, H. J., Wadiasingh, Z., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Yu Wun, Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zorn, J., Zouari, S., Żywucka, N., and Acero, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The identification of PeVatrons, hadronic particle accelerators reaching the knee of the cosmic ray spectrum (few $10^{15}$ eV), is crucial to understand the origin of cosmic rays in the Galaxy. We provide an update on the unidentified source HESS J1702-420, a promising PeVatron candidate. We present new observations of HESS J1702-420 made with the High Energy Stereoscopic System (H.E.S.S.), and processed using improved analysis techniques. The analysis configuration was optimized to enhance the collection area at the highest energies. We applied a three-dimensional (3D) likelihood analysis to model the source region and adjust non thermal radiative spectral models to the $\gamma$-ray data. We also analyzed archival data from the Fermi Large Area Telescope (LAT) to constrain the source spectrum at $\gamma$-ray energies >10 GeV. We report the detection of a new source component called HESS J1702-420A, that was separated from the bulk of TeV emission at a $5.4\sigma$ confidence level. The power law $\gamma$-ray spectrum of HESS J1702-420A extends with an index of $\Gamma=1.53\pm0.19_\text{stat}\pm0.20_\text{sys}$ and without curvature up to the energy band 64-113 TeV, in which it was detected by H.E.S.S. at a $4.0\sigma$ confidence level. This brings evidence for the source emission up to $100\,\text{TeV}$, which makes HESS J1702-420A a compelling candidate site for the presence of extremely high energy cosmic rays. Remarkably, in a hadronic scenario, the cut-off energy of the proton distribution powering HESS J1702-420A is found to be higher than 0.5 PeV at a 95% confidence level. HESS J1702-420A becomes therefore one of the most solid PeVatron candidates detected so far in H.E.S.S. data, altough a leptonic origin of its emission could not be ruled out either., Comment: Accepted for publication in the 2. Astrophysical processes section of Astronomy & Astrophysics
Published: 2021
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167. Search for dark matter annihilation signals from unidentified Fermi-LAT objects with H.E.S.S

Author: Collaboration, H. E. S. S., Abdallah, H., Aharonian, F., Benkhali, F. Ait, Angüner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Martins, V. Barbosa, Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., de Lavergne, M. de Bony, Breuhaus, M., Brose, R., Brun, F., Bulik, T., Bylund, T., Cangemi, F., Caroff, S., Casanova, S., Chambery, P., Chand, J. Catalano T., Chen, A., Cotter, G., Curylo, M., Dalgleish, H., Mbarubucyeye, J. Damascene, Davids, I. D., Davies, J., Devin, J., Djannati-Ataï, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dreyer, L., Plessis, L. Du, Duffy, C., Egberts, K., Einecke, S., Emery, G., Ernenwein, J. -P., Feijen, K., Fegan, S., Fiasson, A., de Clairfontaine, G. Fichet, Fontaine, G., Funk, S., Füßling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Grondin, M. -H., Hattingh, S., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Hörbe, M., Horns, D., Huang, Z., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzyński, K., Katz, U., Khangulyan, D., Khèlifi, B., Klepser, S., Kluzniak, W., Komin, Nu., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Mezek, G. Kukec, Kundu, A., Lamanna, G., Stum, S. Le, Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Leuschner, F., Levy, C., Lohse, T., Luashvili, A., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Martì-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., de Naurois, M., Ndiyavala, H., Niemiec, J., Noel, A., Oberholzer, L., O'Brien, P., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panter, M., Panny, S., Parsons, R. D., Peron, G., Pita, S., Poireau, V., Prokhorov, D. A., Prokoph, H., Pühlhofer, G., Punch, M., Quirrenbach, A., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Romoli, C., Rowell, G., Rudak, B., Ricarte, H. Rueda, Ruiz-Velasco, E., Sahakian, V., Sailer, S., Salzmann, H., Sanchez, D. A., Santangelo, A., Sasaki, M., Schüssler, F., Schutte, H. M., Schwanke, U., Senniappan, M., Seyffert, A. S., Shapopi, J. N. S., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Spackman, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, L., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tanaka, T., Tavernier, T., Taylor, A. M., Terrier, R., Morgan, C. Thorpe, Thiersen, J. H. E., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tsuji, M., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Viana, A., Vincent, P., Vink, J., Völk, H. J., Wagner, S. J., Werner, F., White, R., Wierzcholska, A., Wong, Yu Wun, Yassin, H., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S., Zmija, A., Zorn, J., Zouari, S., and Zywucka, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Cosmological $N$-body simulations show that Milky Way-sized galaxies harbor a population of unmerged dark matter subhalos. These subhalos could shine in gamma-rays and be eventually detected in gamma-ray surveys as unidentified sources. We performed a thorough selection among unidentified Fermi-LAT Objects (UFOs) to identify them as possible TeV-scale dark matter subhalo candidates. We search for very-high-energy (E $\gtrsim$ 100 GeV) gamma-ray emissions using H.E.S.S. observations towards four selected UFOs. Since no significant very-high-energy gamma-ray emission is detected in any dataset of the four observed UFOs nor in the combined UFO dataset, strong constraints are derived on the product of the velocity-weighted annihilation cross section $\langle \sigma v \rangle$ by the $J$-factor for the dark matter models. The 95% C.L. observed upper limits derived from combined H.E.S.S. observations reach $\langle \sigma v \rangle J$ values of 3.7$\times$10$^{-5}$ and 8.1$\times$10$^{-6}$ GeV$^2$cm$^{-2}$s$^{-1}$ in the $W^+W^-$ and $\tau^+\tau^-$ channels, respectively, for a 1 TeV dark matter mass. Focusing on thermal WIMPs, the H.E.S.S. constraints restrict the $J$-factors to lie in the range 6.1$\times$10$^{19}$ - 2.0$\times$10$^{21}$ GeV$^2$cm$^{-5}$, and the masses to lie between 0.2 and 6 TeV in the $W^+W^-$ channel. For the $\tau^+\tau^-$ channel, the $J$-factors lie in the range 7.0$\times$10$^{19}$ - 7.1$\times$10$^{20}$ GeV$^2$cm$^{-5}$ and the masses lie between 0.2 and 0.5 TeV. Assuming model-dependent predictions from cosmological N-body simulations on the $J$-factor distribution for Milky Way-sized galaxies, the dark matter models with masses greater than 0.3 TeV for the UFO emissions can be ruled out at high confidence level., Comment: 11 pages, 7 figures, matches accepted version in The Astrophysical Journal
Published: 2021
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168. Search for dark matter annihilation in the dwarf irregular galaxy WLM with H.E.S.S

Author: Collaboration, H. E. S. S., Abdallah, H., Adam, R., Aharonian, F., Benkhali, F. Ait, Angüner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Martins, V. Barbosa, Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., de Lavergne, M. de Bony, Breuhaus, M., Brun, F., Brun, P., Bryan, M., Büchele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Casanova, S., Chand, T., Chandra, S., Chen, A., Cotter, G., Curylo, M., Mbarubucyeye, J. Damascene, Davids, I. D., Davies, J., Deil, C., Devin, J., deWilt, P., Dirson, L., Djannati-Ataï, A., Dmytriiev, A., Donath, A., Doroshenko, V., Duffy, C., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J. -P., Feijen, K., Fegan, S., Fiasson, A., de Clairfontaine, G. Fichet, Fontaine, G., Funk, S., Füßling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Hörbe, M., Horns, D., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kasai, E., Kastendieck, M. A., Katarzyński, K., Katz, U., Khangulyan, D., Khèlifi, B., Klepser, S., Kluzniak, W., Komin, Nu., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Martì-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Moderski, R., Mohamed, M., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., de Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O'Brien, P., Odaka, H., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panter, M., Panny, S., Parsons, R. D., Peron, G., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Noel, A. Priyana, Prokhorov, D. A., Prokoph, H., Pühlhofer, G., Punch, M., Quirrenbach, A., Raab, S., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Scalici, M., Schüssler, F., Schutte, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, L., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Völk, H. J., Vuillaume, T., Wadiasingh, Z., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Yu Wun, Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S., Zorn, J., Zouari, S., and Zywucka, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract: We search for an indirect signal of dark matter through very high-energy gamma rays from the Wolf-Lundmark-Melotte (WLM) dwarf irregular galaxy. The pair annihilation of dark matter particles would produce Standard Model particles in the final state such as gamma rays, which might be detected by ground-based Cherenkov telescopes. Dwarf irregular galaxies represent promising targets as they are dark matter dominated objects with well measured kinematics and small uncertainties on their dark matter distribution profiles. In 2018, the H.E.S.S. five-telescope array observed the dwarf irregular galaxy WLM for 18 hours. We present the first analysis based on data obtained from an imaging atmospheric Cherenkov telescope for this subclass of dwarf galaxy. As we do not observe any significant excess in the direction of WLM, we interpret the result in terms of constraints on the velocity-weighted cross section for dark matter pair annihilation as a function of the dark matter particle mass for various continuum channels as well as the prompt gamma-gamma emission. For the $\tau^+\tau^-$ channel the limits reach a $\langle \sigma v \rangle$ value of about $4\times 10^{-22}$ cm3s-1 for a dark matter particle mass of 1 TeV. For the prompt gamma-gamma channel, the upper limit reaches a $\langle \sigma v \rangle$ value of about $5 \times10^{-24}$ cm3s-1 for a mass of 370 GeV. These limits represent an improvement of up to a factor 200 with respect to previous results for the dwarf irregular galaxies for TeV dark matter search., Comment: 13 pages, 5 figures
Published: 2021
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169. Tank-Circuit Assisted Coupling Method for Sympathetic Laser Cooling

Author: Tu, Bingsheng, Hahne, Felix, Arapoglou, Ioanna, Egl, Alexander, Heiße, Fabian, Höcker, Martin, König, Charlotte, Morgner, Jonathan, Sailer, Tim, Weigel, Andreas, Wolf, Robert, and Sturm, Sven
Subjects: Quantum Physics, Physics - Atomic Physics
Abstract: We discuss the coupling of the motion of two ion species in separate Penning traps via a common tank circuit. The enhancement of the coupling assisted by the tank circuit is demonstrated by an avoided crossing behavior measurement of the motional modes of two coupled ions. We propose an intermittent laser cooling method for sympathetic cooling and provide a theoretical description. The technique enables tuning of the coupling strength between two ion species in separate traps and thus allows for efficient sympathetic cooling of an arbitrary type of single ion for high-precision Penning-trap experiments.
Published: 2021
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170. Physics performance for Dark Matter searches at $\sqrt{s}=$ 3 TeV at CLIC using mono-photons and polarised beams

Author: Blaising, J-J., Roloff, P., Sailer, A., and Schnoor, U.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: The potential for detecting DM at the Compact Linear Collider (CLIC) is investigated at \mbox{$\sqrt{s}=$ 3 TeV}. The sensitivity of the search is estimated by computing the 95\% confidence level upper limit cross section as a function of the dark matter mass. Left-handed (right-handed) polarised \Pem beams increase (decrease) respectively the Standard Model backgrounds and are essential to characterize the WIMPs properties and control the systematic errors. Using right-handed polarised \Pem beams is decreasing significantly the 95\% confidence level cross section. Using the ratio of the energy distributions for left-handed and right-handed polarised \Pem beams, systematic errors cancel out. Computing the 95\% confidence level upper limit cross section using the ratio requires a model assumption to compute the expected number of signal events. Exclusion limits for dark matter are derived using dark matter Simplified Models for two values of the e-e-mediator vertex coupling, a mediator width of 10 GeV and for a fixed value of the mediator-DM-DM coupling. For a mediator mass of 3.5 TeV, the measurement of the differential distribution of the significance as a function of the photon energy for the process \mbox{\Pem \Pep $\to$ X X \PGg} allows the discrimination between different dark matter mediators and the measurement of the WIMP mass to nearly half the centre-of-mass energy. For a \mbox{1 TeV} WIMP, the mass is determined with a 1\% accuracy.
Published: 2021

171. Effects of Harvest Date and Ensiling Additives on the Optimized Ensiling of Silphium Perfoliatum to Prevent Faulty Fermentation

Author: Marian Baumgart, Benedikt Hülsemann, Gregor Sailer, Hans Oechsner, and Joachim Müller
Subjects: cup plant, ensilage, fermentation issues, energy crops, bioeconomy, butyric acid, Agriculture (General), S1-972
Abstract: Silphium perfoliatum, an energy crop with a high fiber content but low concentrations of fermentable carbohydrates, presents challenges for complete fermentation in biogas production. To overcome this, a bioeconomic approach proposes the use of the fibers for paper and board production, which requires high-quality silage with minimal butyric acid, which affects the marketability of the fibers. This study aims to optimize the silaging process of Silphium perfoliatum by investigating the effects of harvest date, bacterial cultures and additives on fermentation results. Laboratory experiments were conducted to evaluate the effect of three harvest dates on fermentation acid composition, with a focus on increasing lactic acid production to inhibit butyric acid formation. Results indicate that an early harvest date (early September) is critical for achieving stable fermentation and minimizing ensiling losses. The addition of sugar-rich additives, such as syrup, was found to be essential, especially for later harvest dates. Despite these interventions, a late harvest (early November) consistently resulted in suboptimal fermentation. The results suggest that optimizing harvest timing and incorporating appropriate additives are key strategies for producing high quality silage and ensuring the suitability of Silphium perfoliatum fibers for industrial applications.
Published: 2024
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172. Aggregatibacter actinomycetemcomitans Dispersin B: The Quintessential Antibiofilm Enzyme

Author: Jeffrey B. Kaplan, Svetlana A. Sukhishvili, Miloslav Sailer, Khalaf Kridin, and Narayanan Ramasubbu
Subjects: biofilm matrix, biomaterial coating, DspB, EPS, exopolysaccharide, extracellular DNA, Medicine
Abstract: The extracellular matrix of most bacterial biofilms contains polysaccharides, proteins, and nucleic acids. These biopolymers have been shown to mediate fundamental biofilm-related phenotypes including surface attachment, intercellular adhesion, and biocide resistance. Enzymes that degrade polymeric biofilm matrix components, including glycoside hydrolases, proteases, and nucleases, are useful tools for studying the structure and function of biofilm matrix components and are also being investigated as potential antibiofilm agents for clinical use. Dispersin B is a well-studied, broad-spectrum antibiofilm glycoside hydrolase produced by Aggregatibacter actinomycetemcomitans. Dispersin B degrades poly-N-acetylglucosamine, a biofilm matrix polysaccharide that mediates biofilm formation, stress tolerance, and biocide resistance in numerous Gram-negative and Gram-positive pathogens. Dispersin B has been shown to inhibit biofilm and pellicle formation; detach preformed biofilms; disaggregate bacterial flocs; sensitize preformed biofilms to detachment by enzymes, detergents, and metal chelators; and sensitize preformed biofilms to killing by antiseptics, antibiotics, bacteriophages, macrophages, and predatory bacteria. This review summarizes the results of nearly 100 in vitro and in vivo studies that have been carried out on dispersin B since its discovery 20 years ago. These include investigations into the biological function of the enzyme, its structure and mechanism of action, and its in vitro and in vivo antibiofilm activities against numerous bacterial species. Also discussed are potential clinical applications of dispersin B.
Published: 2024
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173. Dynamic Demand Management for Parcel Lockers.

Author: Daniela Sailer, Robert Klein, and Claudius Steinhardt
Published: 2024
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174. AutoChemplete - Making Chemical Structural Formulas Accessible.

Author: Merlin Knaeble, Gabriel Sailer, Zihan Chen, Thorsten Schwarz, Kailun Yang 0001, Mario Nadj, Rainer Stiefelhagen, and Alexander Maedche
Published: 2023
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175. GIS-Kompetenz als Future Skill für geographiespezifische Berufsfelder : Fünf Good-Practice-Beispiele und ihre didaktische Konzeption

Author: Sailer, Christian, Engel, Marcel, Otto, Jonathan, Wilkening, Jan, Pettig, Fabian, editor, and Gryl, Inga, editor
Published: 2023
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176. Molekulare Mechanismen der Resistenzentstehung und pathologische Aspekte der Therapieplanung beim Prostatakarzinom

Author: Sailer, Verena, Perner, Sven, Merseburger, Axel S., editor, and Roesch, Marie C., editor
Published: 2023
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177. The Compact Catalytical Heater (CCH): Thermal Management for HD EU-VII/EPA-27 with Low Impact on Existing EATS Architectures

Author: Presti, Manuel, Holz, Oswald, Keck, Mathias, Sailer, Dennis, and Heintzel, Alexander, editor
Published: 2023
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178. Digitales Niemandsland? Eine Bestandsaufnahme der digitalen Bildung an deutschen Kindertageseinrichtungen

Author: Wirth, Astrid, Lohr, Anne, Sailer, Michael, Niklas, Frank, Gogolin, Ingrid, Series Editor, and Scheiter, Katharina, editor
Published: 2023
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179. Cholesterol and Phosphoinositides in Cilia Biology

Author: Sailer, Steffen-Alexander, Burkhalter, Martin D., Philipp, Melanie, and Dantsker, Avia Rosenhouse-, editor
Published: 2023
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180. Non-drug Treatment Approaches and Neurorehabilitation

Author: Sailer, M., Sweeney-Reed, C. M., Lamprecht, J., and Penner, Iris-Katharina, editor
Published: 2023
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181. Cosmology at high redshift - A probe of fundamental physics

Author: Sailer, N, Castorina, E, Ferraro, S, and White, M
Subjects: Particle and High Energy Physics, Astronomical Sciences, Physical Sciences, cosmological parameters from LSS, cosmological perturbation theory, gravitational lensing, redshift surveys, astro-ph.CO, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Nuclear & Particles Physics, Astronomical sciences, Particle and high energy physics
Abstract: An observational program focused on the high redshift (2
Published: 2021

182. DNA methylation episignature, extension of the clinical features, and comparative epigenomic profiling of Hao-Fountain syndrome caused by variants in USP7

Author: van der Laan, Liselot, Karimi, Karim, Rooney, Kathleen, Lauffer, Peter, McConkey, Haley, Caro, Pilar, Relator, Raissa, Levy, Michael A., Bhai, Pratibha, Mignot, Cyril, Keren, Boris, Briuglia, Silvana, Sobering, Andrew K., Li, Dong, Vissers, Lisenka E.L.M., Dingemans, Alexander J.M., Valenzuela, Irene, Verberne, Eline A., Misra-Isrie, Mala, Zwijnenburg, Petra J.G., Waisfisz, Quinten, Alders, Mariëlle, Sailer, Sebastian, Schaaf, Christian P., Mannens, Marcel M.A.M., Sadikovic, Bekim, van Haelst, Mieke M., and Henneman, Peter
Published: 2024
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183. Effect of dulaglutide in promoting abstinence during smoking cessation: 12-month follow-up of a single-centre, randomised, double-blind, placebo-controlled, parallel group trial

Author: Lüthi, Hualin, Lengsfeld, Sophia, Burkard, Thilo, Meienberg, Andrea, Jeanloz, Nica, Vukajlovic, Tanja, Bologna, Katja, Steinmetz, Michelle, Bathelt, Cemile, Sailer, Clara O., Laager, Mirjam, Vogt, Deborah R., Hemkens, Lars G., Speich, Benjamin, Urwyler, Sandrine A., Kühne, Jill, Baur, Fabienne, Lutz, Linda N., Erlanger, Tobias E., Christ-Crain, Mirjam, and Winzeler, Bettina
Published: 2024
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184. Research Priorities of the Pediatric Spinal Cord Injury Population: An International Insight for Rehabilitation Care

Author: Arango Lasprilla, Juan Carlos, Augutis, Marika, Graham, Allison, Kontaxakis, Antonis, López Dolado, Elisa, Onal, Bashak, Ríos León, Marta, Scheel-Sailer, Anke, Taylor, Julian, Valiullina, Svetlana, Rapidi, Christina Anastasia, Pyrgeli, Maria, Dalivigka, Zoi, Armakola, Filomeni, Civicos Sánchez, Nora, Köhler, Jutta, Vogel, Lawrence C., Zebracki, Kathy, Stavrianou, Aggeliki, Kelly, Erin, Ertzgaard, Per, Eriks Hoogland, Inge, Mecci, Munawar, Salvati, Jessica, Viala, Carey, Aung, Wunna, Alekseeva, Angelina, Gaymanova, Maya, Novoselova, Irina, Popova, Olga, Wright, Karina, Osman, Aheed E., Chowdhury, Joy Roy, Kumar, Naveen, Fosbrook, Emma, Edwards, Jayne, Hakova, Renata, Kriz, Jiri, Thumbikat, Pradeep, Yin, Han, Hariharan, Ram, Mathew, Kidangalil, Gall, Angela, Wallace, Natasha, Wahman, Kerstin, Bendt, Martina, Hart, Kirsten, Jones, Kevin, Mokri, Vida, Whicher, Emily, van Middendorp, Joost, Mattacola, Emily, Corroto, Ana María Escobar, Ceruelo-Abajo, Silvia, Figueres, Ana Onate, Ríos-León, Marta, Arango-Lasprilla, Juan Carlos, Kelly, Erin Hayes, and López-Dolado, Elisa
Published: 2024
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185. Common femoral arterial access and arteriography in infants: Principles, pearls, and pitfalls

Author: Sailer, A., Fitzgerald, K., Chick, J.F.B., Shin, D.S., and Monroe, E.J.
Published: 2024
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186. ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors

Author: Hong, Yeonsun, Walling, Brandon L., Kim, Hye-Ran, Serratelli, William S., Lozada, John R., Sailer, Cooper J., Amitrano, Andrea M., Lim, Kihong, Mongre, Raj Kumar, Kim, Kyun-Do, Capece, Tara, Lomakina, Elena B., Reilly, Nicholas S., Vo, Kevin, Gerber, Scott A., Fan, Tan-Chi, Yu, Alice Lin-Tsing, Oakes, Patrick W., Waugh, Richard E., Jun, Chang-Duk, Reagan, Patrick M., and Kim, Minsoo
Published: 2023
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187. Search for tri-nucleon decays of $$^{76}$$ 76 Ge in GERDA

Author: M. Agostini, A. Alexander, G. Araujo, A. M. Bakalyarov, M. Balata, I. Barabanov, L. Baudis, C. Bauer, S. Belogurov, A. Bettini, L. Bezrukov, V. Biancacci, E. Bossio, V. Bothe, R. Brugnera, A. Caldwell, S. Calgaro, C. Cattadori, A. Chernogorov, P.-J. Chiu, T. Comellato, V. D’Andrea, E. V. Demidova, A. Di Giacinto, N. Di Marco, E. Doroshkevich, F. Fischer, M. Fomina, A. Gangapshev, A. Garfagnini, C. Gooch, P. Grabmayr, V. Gurentsov, K. Gusev, J. Hakenmüller, S. Hemmer, W. Hofmann, M. Hult, L. V. Inzhechik, J. Janicskó Csáthy, J. Jochum, M. Junker, V. Kazalov, Y. Kermaïdic, H. Khushbakht, T. Kihm, K. Kilgus, I. V. Kirpichnikov, A. Klimenko, K. T. Knöpfle, O. Kochetov, V. N. Kornoukhov, P. Krause, V. V. Kuzminov, M. Laubenstein, M. Lindner, I. Lippi, A. Lubashevskiy, B. Lubsandorzhiev, G. Lutter, C. Macolino, B. Majorovits, W. Maneschg, L. Manzanillas, G. Marshall, M. Misiaszek, M. Morella, Y. Müller, I. Nemchenok, M. Neuberger, L. Pandola, K. Pelczar, L. Pertoldi, P. Piseri, A. Pullia, L. Rauscher, M. Redchuk, S. Riboldi, N. Rumyantseva, C. Sada, S. Sailer, F. Salamida, S. Schönert, J. Schreiner, M. Schütt, A.-K. Schütz, O. Schulz, M. Schwarz, B. Schwingenheuer, O. Selivanenko, E. Shevchik, M. Shirchenko, L. Shtembari, H. Simgen, A. Smolnikov, D. Stukov, S. Sullivan, A. A. Vasenko, A. Veresnikova, C. Vignoli, K. von Sturm, T. Wester, C. Wiesinger, M. Wojcik, E. Yanovich, B. Zatschler, I. Zhitnikov, S. V. Zhukov, D. Zinatulina, A. Zschocke, A. J. Zsigmond, K. Zuber, G. Zuzel, and GERDA collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract We search for tri-nucleon decays of $$^{76}$$ 76 Ge in the dataset from the GERmanium Detector Array (GERDA) experiment. Decays that populate excited levels of the daughter nucleus above the threshold for particle emission lead to disintegration and are not considered. The ppp-, ppn-, and pnn-decays lead to $$^{73}$$ 73 Cu, $$^{73}$$ 73 Zn, and $$^{73}$$ 73 Ga nuclei, respectively. These nuclei are unstable and eventually proceed by the beta decay of $$^{73}$$ 73 Ga to $$^{73}$$ 73 Ge (stable). We search for the $$^{73}$$ 73 Ga decay exploiting the fact that it dominantly populates the 66.7 keV $$^{73m}$$ 73 m Ga state with half-life of 0.5 s. The nnn-decays of $$^{76}$$ 76 Ge that proceed via $$^{73m}$$ 73 m Ge are also included in our analysis. We find no signal candidate and place a limit on the sum of the decay widths of the inclusive tri-nucleon decays that corresponds to a lower lifetime limit of 1.2 $$\times $$ × 10 $$^{26}$$ 26 yr (90% credible interval). This result improves previous limits for tri-nucleon decays by one to three orders of magnitude.
Published: 2023
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188. Gesellschaftlicher Zusammenhalt und Zufriedenheit mit staatlichen Institutionen in Zeiten von Corona

Author: Sailer, Marie Lisa, primary
Published: 2023
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189. Messung instrumenteller und kritisch-reflexiver Medienkompetenzen sowie medienbezogener Lehrkompetenzen von (angehenden) Lehrkräften

Author: Johanna Vejvoda, Matthias Stadler, Florian Schultz-Pernice, Julia Glas, Frank Fischer, and Michael Sailer
Subjects: Medienkompetenz, Messung, Szenarien-basierte Messung, Selbsteinschätzung, Medienbezogene Lehrkompetenz, Lehrkräfte, Special aspects of education, LC8-6691
Abstract: Medienbezogene Kompetenzen von Lehrkräften sind unabdingbar, um Schüler:innen auf Teilhabe, Partizipation und eine verantwortliche Mitgestaltung in einer Kultur der Digitalität vorzubereiten. Konkret benötigen Lehrkräfte hierzu medienbezogene Basis- und Lehrkompetenzen. Für die zielgerichtete und erfolgreiche Förderung dieser Kompetenzen im Rahmen der Lehrkräftebildung sind Instrumente zur Messung dieser Medienkompetenzen hilfreich. Bestehende Instrumente greifen allerdings zumeist auf einfache, nicht selten sehr allgemein formulierte Selbsteinschätzungen zurück. Dies erschwert eine valide Messung von Kompetenzen. In diesem Beitrag wird ein alternativer Messansatz vorgestellt, der Selbsteinschätzungen von Medienkompetenzen mittels Szenarien kontextualisiert und damit präzisiert. Die Szenarien-Basierung führt zu einem validen Messergebnis, hat aber für den Einsatz im Feld den Nachteil, dass die Messung deutlich umfangreicher ausfällt. Dem begegnen wir im vorliegenden Beitrag durch die Entwicklung einer Kurzskala in einem mehrstufigen Verfahren. Auf Basis eines Datensatzes von N = 552 (angehenden) Lehrkräften wird eine szenarienbasierte Kurzskala zur Messung instrumenteller und kritisch-reflexiver Medienkompetenzen sowie medienbezogener Lehrkompetenzen entwickelt. Diese Kurzskala wird in einer weiteren Studie mit N = 204 Lehrkräften nochmals validiert. Die Ergebnisse beider Studien unterstützen die Validität der Kurzskala. Für die Lehrkräftebildung und Forschung wird somit ein akzeptanzförderndes und ressourcenschonendes Instrument bereitgestellt, das eine reliable und valide Messung instrumenteller und kritisch-reflexiver Medienkompetenzen sowie medienbezogener Lehrkompetenzen erlaubt.
Published: 2024
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190. Assessments and interventions on body functions, structures and activity to prepare adults with acute spinal cord injury or disease for participation: a scoping review

Author: Sophie Irrgang, Sandra Himmelhaus, Kirstin Allek, Isabelle Debecker, Armin Gemperli, Karen Kynast, Anne von Reumont, and Anke Scheel-Sailer
Subjects: spinal cord injury, acute phase, physiotherapy, occupational therapy, functioning, Other systems of medicine, RZ201-999, Medical technology, R855-855.5
Abstract: IntroductionIn the acute phase after a spinal cord injury or disease (SCI/D), various therapeutic assessments and interventions are applied with the goal of restoring structures, preventing complications and preparing the patient as best as possible for further activity and finally participation. The goal was to identify and evaluate the available evidence on assessments and interventions for body functions and structures to prepare adults with acute spinal cord SCI/D for activity and participation during the first 14 days.MethodsA scoping review was conducted. The search was performed on June 19, 2023 using the databases PubMed, PEDro, Cochrane library and Embase. These were screened for studies including patients with acute SCI/D and physiotherapeutic or occupational therapy assessments and interventions. Only studies in English or German published between 2012 and 2023 were included.ResultsTwelve publications met the inclusion criteria, namely three systematic reviews, two randomized controlled trials, two observational studies and five clinical practice guidelines. Assessments as the Spinal Cord Independence Measure, as well as exercises such as daily passive mobilization of body structures against contractures were used in the entire population, while others were only applied in subgroups of SCI/D such as the Graded Redefined Assessment of Strength, Sensation and Prehension or functional electrical stimulation with and without additional movements. The methodological quality of the studies found varied greatly from good to very poor.DiscussionHeterogeneity in research design and study population as well as lack of high-quality studies do not cover the standard of clinical management in the acute phase and further comprehensive research is needed.
Published: 2024
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191. Dorsal CA1 lesions of the hippocampus impact mating tactics in prairie voles by shifting non-monogamous males’ use of space to resemble monogamous males

Author: Lindsay L. Sailer, Caitlyn J. Finton, Pooja P. Patel, Steven M. Bogdanowicz, and Alexander G. Ophir
Subjects: dCA1, mating tactics, prairie vole, reproductive success, space use, spatial cognition, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Alternative mating tactics within mating systems are characterized by discrete patterns of spatio-temporal overlap with same-and opposite-sex conspecifics and mating-relevant outcomes. Socially monogamous “residents” maintain relatively small home range sizes, have territories that almost exclusively overlap with their mating partners, and are more likely to produce offspring than non-bonded “wandering” conspecifics. Because mating tactics appear to be so closely tied to patterns of space use, differences in spatial cognitive abilities might differentially impact individual males’ decisions to adopt a particular mating tactic and/or how efficient they are within their chosen mating tactic. Yet few studies have considered how the hippocampus, a brain region important for encoding cognitive maps and for processing contextual information, might impact how individuals adopt mating tactics or the spatio-temporal behaviors closely associated with them. We assessed the impact of lesions to the dorsal CA1 (dCA1) region of the hippocampus on male prairie vole space use, reproductive success, and mating tactics in semi-natural outdoor field conditions. Interestingly, dCA1 lesions did not impact the proportion of males that adopted resident or wandering mating tactics, and dCA1 lesions did not impact a male’s ability to form a pair bond in the lab. In contrast, we found that lesioning the dCA1 shifted the home range size of reproductively successful and unsuccessful males. Furthermore, we found that patterns of space use among residents were unaffected by dCA1 lesions, whereas wanderers with dCA1 lesions showed pronounced reductions of their space use habits and resembled non-lesioned residents. Collectively, our study supports the hypothesis that wanderer male prairie voles rely on dCA1-mediated spatial cognition to navigate their world in a way that resident males do not. Such differences might have implications for how individuals efficiently attract and defend mates, obtain resources, defend territories, and outcompete rivals.
Published: 2024
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192. Effect of dulaglutide in promoting abstinence during smoking cessation: 12-month follow-up of a single-centre, randomised, double-blind, placebo-controlled, parallel group trialResearch in context

Author: Hualin Lüthi, Sophia Lengsfeld, Thilo Burkard, Andrea Meienberg, Nica Jeanloz, Tanja Vukajlovic, Katja Bologna, Michelle Steinmetz, Cemile Bathelt, Clara O. Sailer, Mirjam Laager, Deborah R. Vogt, Lars G. Hemkens, Benjamin Speich, Sandrine A. Urwyler, Jill Kühne, Fabienne Baur, Linda N. Lutz, Tobias E. Erlanger, Mirjam Christ-Crain, and Bettina Winzeler
Subjects: Glucagon-like peptide-1 (GLP-1) analogues, Quitting smoking, Long-term abstinence, Post-cessation weight gain, Medicine (General), R5-920
Abstract: Summary: Background: Smoking cessation is challenging, despite making use of established smoking cessation therapies. Preclinical studies and one clinical pilot study suggest the antidiabetic drug glucagon-like peptide-1 (GLP-1) analogue to modulate addictive behaviours and nicotine craving. Previously, we reported the short-term results of a randomised, double-blind, placebo-controlled trial. Herein we report long-term abstinence rates and weight developments after 24 and 52 weeks. Methods: This single-centre, randomised, double-blind, placebo-controlled, parallel group trial was done at the University Hospital Basel in Switzerland. We randomly assigned (1:1) individuals with at least a moderate nicotine dependence willing to quit smoking to either a 12-week treatment with dulaglutide 1.5 mg or placebo subcutaneously once weekly in addition to standard of care smoking cessation therapy (varenicline 2 mg/day and behavioural counselling). After 12 weeks, dulaglutide or placebo injections were discontinued and the participants were followed up at week 24 and 52. The primary outcome of self-reported and biochemically confirmed point prevalence abstinence rate, and secondary outcome of secondary outcome of weight change were assessed at weeks 24 and 52. All participants who received one dose of the study drug were included in the intention to treat set and participants who received at least 10/12 doses of the study drug formed the per protocol set. The trial was registered at ClinicalTrials.gov, NCT03204396. Findings: Of the 255 participants who were randomly assigned between June 22, 2017 and December 3, 2020, 63% (80/127) (dulaglutide group) and 65% (83/128) (placebo group) were abstinent after 12 weeks. These abstinence rates declined to 43% (54/127) and 41% (52/128), respectively, after 24 weeks and to 32% (41/127) and 32% (41/128), respectively, after 52 weeks. Post-cessation weight gain was prevented in the dulaglutide group (−1.0 kg, standard deviation [SD] 2.7) as opposed to the placebo group (+1.9 kg, SD 2.4) after 12 weeks. However, at week 24, increases in weight from baseline were observed in both groups (median, interquartile range [IQR]: dulaglutide: +1.5 kg, [−0.4, 4.1], placebo: +3.0 kg, [0.6, 4.6], baseline-adjusted difference in weight change −1.0 kg (97.5% CI [−2.16, 0.16])), and at week 52 the groups showed similar weight gain (median, IQR: dulaglutide: +2.8 kg [−0.4, 4.7], placebo: +3.1 kg [−0.4, 6.0], baseline-adjusted difference in weight change: −0.35 kg (95% CI [−1.72, 1.01])). In the follow-up period (week 12 to week 52) 51 (51%) and 48 (48%) treatment-unrelated adverse events were recorded in the dulaglutide and the placebo group, respectively. No treatment-related serious adverse events or deaths occurred. Interpretation: Dulaglutide does not improve long-term smoking abstinence, but has potential to counteract weight gain after quitting. However, 3 months of treatment did not have a sustained beneficial effect on weight at 1 year. As post-cessation weight gain is highest in the first year after quitting smoking, future studies should consider a longer treatment duration with a GLP-1 analogue in abstinent individuals. Funding: Swiss National Science Foundation, the Gottfried and Julia Bangerter-Rhyner Foundation, the Goldschmidt-Jacobson Foundation, the Hemmi-Foundation, the University of Basel, the Swiss Academy of Medical Sciences.
Published: 2024
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193. Comprehensive transcriptomic analysis of prostate cancer lung metastases.

Author: Alireza Saraji, Katharina Wulf, Janine Stegmann-Frehse, Duan Kang, Anne Offermann, Danny Jonigk, Mark Philipp Kuehnel, Jutta Kirfel, Sven Perner, and Verena Wilbeth Sailer
Subjects: Medicine, Science
Abstract: Metastatic prostate cancer (mPCa) is a widespread disease with high mortality. Unraveling molecular mechanisms of disease progression is of utmost importance. The microenvironment in visceral organs and the skeletal system is of particular interest as a harbinger of metastatic spread. Therefore, we performed a comprehensive transcriptomic analysis of prostate cancer lung metastases with a special focus on differentially expressed genes attributable to the microenvironment. Digital gene expression analysis using the NanoString nCounter analysis system was performed on formalin-fixed, paraffin-embedded (FFPE) tissue from prostate cancer (PCa) lung metastases (n = 24). Data were compared to gene expression data from primary PCa and PCa bone metastases. Bioinformatic analysis was performed using several publicly available tools. In comparison to prostate cancer bone metastases, 209 genes were significantly upregulated, and 100 genes were significantly downregulated in prostate cancer lung metastases. Among the up-regulated genes, the top 10 genes with the most significant P-value were HLA-DPB1, PTPRC, ITGB7, C3, CCL21, CCL5, ITGAM, SERPINA1, MFAP4, ARAP2 and among the down-regulated genes, the top 10 genes with the most significant P-value were FOXC2, TWIST1, CDK14, CHAD, IBSP, EPN3, VIT, HAPLN1, SLC44A4, TBX1. In PCa lung metastases genes associated with immunogenic responses were upregulated while genes associated with epithelial-mesenchymal transition were down-regulated. We also showed that CXCR3/CXCL10 axis plays a significant role in prostate cancer lung metastases in comparison to bone metastases. In this study, we comprehensively explored transcriptomic alterations in PCa lung metastases in comparison to primary PCa and PCa bone metastases. In PCa lung metastases genes associated with immunogenic responses are upregulated while genes associated with epithelial-mesenchymal transition are down-regulated. This points to a more immunogenic phenotype of PCa lung metastases thus potentially making patients more susceptible to immunotherapeutic approaches.
Published: 2024
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194. Revisiting functioning recovery in persons with spinal cord injury undergoing first rehabilitation: Trajectory and network analysis of a Swiss cohort study.

Author: Jsabel Hodel, Carla Sabariego, Mayra Galvis Aparicio, Anke Scheel-Sailer, Vanessa Seijas, and Cristina Ehrmann
Subjects: Medicine, Science
Abstract: Information about an individual's functioning and its longitudinal development is key to informing clinical rehabilitation. However, the description and understanding of the detailed longitudinal course of functioning, i.e., functioning trajectories, is rare in the current SCI literature. The aim of this study was to re-estimate previously identified functioning trajectories of individuals with spinal cord injury (SCI) undergoing initial rehabilitation in Switzerland using trajectory analysis, and to identify highly influential functioning domains that could become trajectory-specific targets for clinical interventions using network analysis. The study was based on data from the Swiss SCI Cohort Study and included individuals with SCI (N = 1099) who completed their rehabilitation in one of four collaborating centers between May 2013 and March 2022. For the trajectory analysis, functioning was operationalized using the total sum score of the Spinal Cord Independence Measure version III (SICM III), which was assessed at up to four time points (T1-T4) during rehabilitation. For the network analysis, individual SCIM III items were used to operationalize relevant functioning problems at T1 (admission) and T4 (discharge). The re-estimation of trajectory analysis confirmed the previously identified mean functioning trajectory classes of stable high functioning (N = 239; 21.75%), early (N = 33; 3.00%), moderate (N = 753; 68.52%), and slow (N = 74; 6.73%) functioning improvement. The network analysis revealed highly connected functioning problems at T1 for the moderate functioning improvement class, including "Feeding", "Dressing upper body", and "Dressing lower body", "Mobility in bed", and "Use of toilet". These functioning domains might indicate potential trajectory-specific targets for clinical interventions. This study has increased our knowledge about functioning trajectories of individuals with SCI undergoing initial rehabilitation in Switzerland and its findings may inform discussions about the application and use of functioning trajectories in clinical practice. Due to the exploratory nature of this study, further research is needed to confirm the findings presented.
Published: 2024
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195. Observation of a sudden cessation of a very-high-energy gamma-ray flare in PKS 1510-089 with H.E.S.S. and MAGIC in May 2016

Author: Collaboration, H. E. S. S., Abdalla, H., Adam, R., Aharonian, F., Benkhali, F. Ait, Angüner, E. O., Arcaro, C., Arm, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Martins, V. Barbosa, Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., Bonnefoy, S., de Lavergne, M. de Bony, Bregeon, J., Breuhaus, M., Brun, F., Brun, P., Bryan, M., Büchele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Casanova, S., Ch, T., Ch, S., Chen, A., Cotter, G., Curyło, M., Mbarubucyeye, J. Damascene, Davids, I. D., Davies, J., Deil, C., Devin, J., deWilt, P., Dirson, L., Djannati-Ataï, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J. -P., Feijen, K., Fegan, S., Fiasson, A., de Clairfontaine, G. Fichet, Filipovic, M., Fontaine, G., Funk, S., Füßling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Hörbe, M., Horns, D., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kastendieck, M. A., Katarzyński, K., Katz, U., Khangulyan, D., Khélifi, B., Klepser, S., Kluźniak, W., Komin, Nu., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Mar, V., Marchegiani, P., Marcowith, A., Mares, A., Martí-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A. M. W., Moderski, R., Mohamed, M., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., de Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O'Brien, P., Odaka, H., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panter, M., Panny, S., Parsons, R. D., Peron, G., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Noel, A. Priyana, Prokhorov, D. A., Prokoph, H., Pühlhofer, G., Punch, M., Quirrenbach, A., Raab, S., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Scalici, M., Schüssler, F., Schutte, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, Ł., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Völk, H. J., Vuillaume, T., Wadiasingh, Z., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Yu Wun, Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zorn, J., Zouari, S., Żywucka, N., Collaboration, MAGIC, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Asano, K., Baack, D., Babić, A., Baquero, A., de Almeida, U. Barres, Barrio, J. A., González, J. Becerra, Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Bil, A., Blanch, O., Bonnoli, G., Bošnjak, Ž., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., neira, E. Do Souto Espi\, Prester, D. Dominis, Donini, A., Dorner, D., Doro, M., Elsaesser, D., Ramazani, V. Fallah, Fattorini, A., Ferrara, G., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., López, R. J. García, Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López, M., López-Coto, R., López-Oramas, A., Loporchio, S., Fraga, B. Machado de Oliveira, Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Mender, S., Mićanović, S., Miceli, D., Miener, T., Minev, M., Mir, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., nil, P. Pe\, Perennes, C., Persic, M., Moroni, P. G. Prada, Pr, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tosti, L., Truzzi, S., van Scherpenberg, J., Vanzo, G., Acosta, M. Vazquez, Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zarić, D., Jorstad, S. G., Marscher, A. P., Boccardi, B., Casadio, C., Hodgson, J., Kim, J. -Y., Krichbaum, T. P., Lähteenmäki, A., Tornikoski, M., Traianou, E., and Weaver, Z. R.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies
Abstract: The flat spectrum radio quasar (FSRQ) PKS 1510-089 is known for its complex multiwavelength behavior, and is one of only a few FSRQs detected at very high energy (VHE, $E>100\,$GeV) $\gamma$-rays. VHE $\gamma$-ray observations with H.E.S.S. and MAGIC during late May and early June 2016 resulted in the detection of an unprecedented flare, which reveals for the first time VHE $\gamma$-ray intranight variability in this source. While a common variability timescale of $1.5\,$hr is found, there is a significant deviation near the end of the flare with a timescale of $\sim 20\,$min marking the cessation of the event. The peak flux is nearly two orders of magnitude above the low-level emission. For the first time, curvature is detected in the VHE $\gamma$-ray spectrum of PKS 1510-089, which is fully explained through absorption by the extragalactic background light. Optical R-band observations with ATOM reveal a counterpart of the $\gamma$-ray flare, even though the detailed flux evolution differs from the VHE ightcurve. Interestingly, a steep flux decrease is observed at the same time as the cessation of the VHE flare. In the high energy (HE, $E>100\,$MeV) $\gamma$-ray band only a moderate flux increase is observed with Fermi-LAT, while the HE $\gamma$-ray spectrum significantly hardens up to a photon index of 1.6. A search for broad-line region (BLR) absorption features in the $\gamma$-ray spectrum indicates that the emission region is located outside of the BLR. Radio VLBI observations reveal a fast moving knot interacting with a standing jet feature around the time of the flare. As the standing feature is located $\sim 50\,$pc from the black hole, the emission region of the flare may have been located at a significant distance from the black hole. If this correlation is indeed true, VHE $\gamma$ rays have been produced far down the jet where turbulent plasma crosses a standing shock., Comment: 25 pages, 17 figures. Accepted for publication by Astronomy & Astrophysics. Corresponding authors: M. Zacharias, J. Sitarek, D. Sanchez, T. Terzic
Published: 2020
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196. Structured light for ultrafast laser micro- and nanoprocessing

Author: Flamm, Daniel, Grossmann, Daniel Günther, Sailer, Marc, Kaiser, Myriam, Zimmermann, Felix, Chen, Keyou, Jenne, Michael, Kleiner, Jonas, Hellstern, Julian, Tillkorn, Christoph, Sutter, Dirk H, and Kumkar, Malte
Subjects: Physics - Optics, Physics - Applied Physics
Abstract: The industrial maturity of ultrashort pulsed lasers has triggered the development of a plethora of material processing strategies. Recently, the combination of these remarkable temporal pulse properties with advanced structured light concepts has led to breakthroughs in the development of novel laser application methods, which will now gradually reach industrial environments. We review the efficient generation of customized focus distributions from the near infrared down to the deep ultraviolet, e.g., based on non-diffracting beams and 3D-beam splitters, and demonstrate their impact for micro- and nanomachining of a wide range of materials. In the beam shaping concepts presented, special attention was paid to suitability for both high energies and high powers., Comment: Accepted manuscript, 19 pages, 20 figures and 111 references
Published: 2020
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197. An extreme particle accelerator in the Galactic plane: HESS J1826$-$130

Author: Collaboration, H. E. S. S., Abdalla, H., Adam, R., Aharonian, F., Benkhali, F. Ait, Angüner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Martins, V. Barbosa, Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., de Lavergne, M. de Bony, Bordas, P., Breuhaus, M., Brun, F., Brun, P., Bryan, M., Büchele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Casanova, S., Chand, T., Chandra, S., Chen, A., Cotter, G., Curyło, M., Mbarubucyeye, J. Damascene, Davids, I. D., Davies, J., Deil, C., Devin, J., deWilt, P., Dirson, L., Djannati-Ataï, A., Dmytriiev, A., Donath, A., Doroshenko, V., Duffy, C., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J. -P., Feijen, K., Fegan, S., Fiasson, A., de Clairfontaine, G. Fichet, Fontaine, G., Funk, S., Füßling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Hörbe, M., Horns, D., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kasai, E., Kastendieck, M. A., Katarzyński, K., Katz, U., Khangulyan, D., Khélifi, B., Klepser, S., Kluźniak, W., Komin, Nu., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Martí-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A., Moderski, R., Mohamed, M., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., de Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O'Brien, P., Odaka, H., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Oya, I., Panter, M., Panny, S., Parsons, R. D., Peron, G., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Noel, A. Priyana, Prokhorov, D. A., Prokoph, H., Pühlhofer, G., Punch, M., Quirrenbach, A., Raab, S., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Scalici, M., Schüssler, F., Schutte, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, Ł., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Völk, H. J., Vuillaume, T., Wadiasingh, Z., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Yu Wun, Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Ziegler, A., Zorn, J., Zouari, S., and Żywucka, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The unidentified very-high-energy (VHE; E $>$ 0.1 TeV) $\gamma$-ray source, HESS J1826$-$130, was discovered with the High Energy Stereoscopic System (HESS) in the Galactic plane. The analysis of 215 h of HESS data has revealed a steady $\gamma$-ray flux from HESS J1826$-$130, which appears extended with a half-width of 0.21$^{\circ}$ $\pm$ 0.02$^{\circ}_{\text{stat}}$ $\pm$ 0.05$^{\circ}_{\text{sys}}$. The source spectrum is best fit with either a power-law function with a spectral index $\Gamma$ = 1.78 $\pm$ 0.10$_{\text{stat}}$ $\pm$ 0.20$_{\text{sys}}$ and an exponential cut-off at 15.2$^{+5.5}_{-3.2}$ TeV, or a broken power-law with $\Gamma_{1}$ = 1.96 $\pm$ 0.06$_{\text{stat}}$ $\pm$ 0.20$_{\text{sys}}$, $\Gamma_{2}$ = 3.59 $\pm$ 0.69$_{\text{stat}}$ $\pm$ 0.20$_{\text{sys}}$ for energies below and above $E_{\rm{br}}$ = 11.2 $\pm$ 2.7 TeV, respectively. The VHE flux from HESS J1826$-$130 is contaminated by the extended emission of the bright, nearby pulsar wind nebula (PWN), HESS J1825$-$137, particularly at the low end of the energy spectrum. Leptonic scenarios for the origin of HESS J1826$-$130 VHE emission related to PSR J1826$-$1256 are confronted by our spectral and morphological analysis. In a hadronic framework, taking into account the properties of dense gas regions surrounding HESS J1826$-$130, the source spectrum would imply an astrophysical object capable of accelerating the parent particle population up to $\gtrsim$200 TeV. Our results are also discussed in a multiwavelength context, accounting for both the presence of nearby supernova remnants (SNRs), molecular clouds, and counterparts detected in radio, X-rays, and TeV energies., Comment: 9 Pages, 5 Figures
Published: 2020
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198. On port-Hamiltonian approximation of a nonlinear flow problem on networks

Author: Liljegren-Sailer, Björn and Marheineke, Nicole
Subjects: Mathematics - Numerical Analysis
Abstract: This paper deals with the systematic development of structure-preserving approximations for a class of nonlinear partial differential equations on networks. The class includes, for example, gas pipe network systems described by barotropic Euler equations. Our approach is guided throughout by energy-based modeling concepts (port-Hamiltonian formalism, theory of Legendre transformation), which provide a convenient and general line of reasoning. Under mild assumptions on the approximation, local conservation of mass, an energy bound, and the inheritance of the port-Hamiltonian structure can be shown. Our approach is not limited to conventional space discretization but also covers complexity reduction of the nonlinearities by inexact integration. Thus, it can serve as a basis for structure-preserving model reduction. Combined with an energy stable time integration, we numerically demonstrate the applicability and good stability properties of the approach using the Euler equations as an example.
Published: 2020

199. An Adaptive Flow-Aware Packet Scheduling Algorithm for Multipath Tunnelling

Author: Sailer, Richard and Hähner, Jörg
Subjects: Computer Science - Networking and Internet Architecture
Abstract: This paper proposes AFMT, a packet scheduling algorithm to achieve adaptive flow-aware multipath tunnelling. AFMT has two unique properties. Firstly, it implements robust adaptive traffic splitting for the subtunnels. Secondly, it detects and schedules bursts of packets cohesively, a scheme that already enabled traffic splitting for load balancing with little to no packet reordering. Several NS-3 experiments over different network topologies show that AFMT successfully deals with changing path characteristics due to background traffic while increasing throughput and reliability., Comment: submitted and accepted on IEEE LCN 2019, 4 pages, 5 figures
Published: 2020
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200. Search for dark matter signals towards a selection of recently-detected DES dwarf galaxy satellites of the Milky Way with H.E.S.S

Author: Collaboration, H. E. S. S., Abdallah, H., Adam, R., Aharonian, F., Benkhali, F. Ait, Angüner, E. O., Arakawa, M., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Martins, V. Barbosa, Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernlöhr, K., Böttcher, M., Boisson, C., Bolmont, J., Bonnefoy, S., Breuhaus, M., Bregeon, J., Brun, F., Brun, P., Bryan, M., Büchele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Casanova, S., Chand, T., Chandra, S., Chen, A., Cotter, G., Curyło, M., Davids, I. D., Davies, J., Deil, C., Devin, J., deWilt, P., Dirson, L., Djannati-Ataï, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dyks, J., Egberts, K., Eichhorn, F., Emery, G., Ernenwein, J. -P., Eschbach, S., Feijen, K., Fegan, S., Fiasson, A., Fontaine, G., Funk, S., Füßling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Hörbe, M., Horns, D., Huber, D., Iwasaki, H., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kastendieck, M. A., Katarzyński, K., Katsuragawa, M., Katz, U., Khangulyan, D., Khélifi, B., Klepser, S., Kluźniak, W., Komin, Nu., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Leser, E., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Martì-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Moderski, R., Mohamed, M., Mohrmann, L., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nakashima, S., de Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O'Brien, P., Odaka, H., Ohm, S., Wilhelmi, E. de Ona, Ostrowski, M., Panter, M., Parsons, R. D., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Noel, A. Priyana, Prokhorov, D. A., Prokoph, H., Pühlhofer, G., Punch, M., Quirrenbach, A., Raab, S., Rauth, R., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Saito, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Scalici, M., Schüssler, F., Schutter, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, Ł., Steenkamp, R., Stegmann, C., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tsuji, N., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Viana, A., Vincent, P., Vink, J., Völk, H. J., Vuillaume, T., Wadiasingh, Z., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Yang, R., Yoneda, H., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S., Zorn, J., and Żywucka, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Dwarf spheroidal galaxy satellites of the Milky Way are prime targets for indirect detection of dark matter with gamma rays due to their proximity, high dark matter content and absence of non-thermal emission processes. Recently, the Dark Energy Survey (DES) revealed the existence of new ultra-faint dwarf spheroidal galaxies in the southern-hemisphere sky, therefore ideally located for ground-based observations with the imaging atmospheric Cherenkov telescope array H.E.S.S. We present a search for very-high-energy ($E\gtrsim100$ GeV) gamma-ray emission using H.E.S.S. observations carried out recently towards Reticulum II, Tucana II, Tucana III, Tucana IV and Grus II satellites. No significant very-high-energy gamma-ray excess is found from the observations on any individual object nor in the combined analysis of all the datasets. Using the most recent modeling of the dark matter distribution in the dwarf galaxy halo, we compute for the first time on DES satellites individual and combined constraints from Cherenkov telescope observations on the annihilation cross section of dark matter particles in the form of Weakly Interacting Massive Particles. The combined 95% C.L. observed upper limits reach $\langle \sigma v \rangle \simeq 1 \times 10^{-23}$ cm$^3$s$^{-1}$ in the $W^+W^-$ channel and $4 \times 10^{-26}$ cm$^3$s$^{-1}$ in the $\gamma\gamma$ channels for a dark matter mass of 1.5 TeV. The H.E.S.S. constraints well complement the results from Fermi-LAT, HAWC, MAGIC and VERITAS and are currently the most stringent in the $\gamma\gamma$ channels in the multi-GeV/multi-TeV mass range., Comment: 20 pages, 12 figures
Published: 2020
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