62,102 results on '"Schaeffer A"'
Search Results
152. Mechanism-centric regulatory network identifies NME2 and MYC programs as markers of Enzalutamide resistance in CRPC
- Author
-
Panja, Sukanya, Truica, Mihai Ioan, Yu, Christina Y., Saggurthi, Vamshi, Craige, Michael W., Whitehead, Katie, Tuiche, Mayra V., Al-Saadi, Aymen, Vyas, Riddhi, Ganesan, Shridar, Gohel, Suril, Coffman, Frederick, Parrott, James S., Quan, Songhua, Jha, Shantenu, Kim, Isaac, Schaeffer, Edward, Kothari, Vishal, Abdulkadir, Sarki A., and Mitrofanova, Antonina
- Published
- 2024
- Full Text
- View/download PDF
153. Scenarios in IPCC assessments: lessons from AR6 and opportunities for AR7
- Author
-
Pirani, Anna, Fuglestvedt, Jan S., Byers, Edward, O’Neill, Brian, Riahi, Keywan, Lee, June-Yi, Marotzke, Jochem, Rose, Steven K., Schaeffer, Roberto, and Tebaldi, Claudia
- Published
- 2024
- Full Text
- View/download PDF
154. Author Correction: Feasibility of peak temperature targets in light of institutional constraints
- Author
-
Bertram, Christoph, Brutschin, Elina, Drouet, Laurent, Luderer, Gunnar, van Ruijven, Bas, Aleluia Reis, Lara, Baptista, Luiz Bernardo, de Boer, Harmen-Sytze, Cui, Ryna, Daioglou, Vassilis, Fosse, Florian, Fragkiadakis, Dimitris, Fricko, Oliver, Fujimori, Shinichiro, Hultman, Nate, Iyer, Gokul, Keramidas, Kimon, Krey, Volker, Kriegler, Elmar, Lamboll, Robin D., Mandaroux, Rahel, Rochedo, Pedro, Rogelj, Joeri, Schaeffer, Roberto, Silva, Diego, Tagomori, Isabela, van Vuuren, Detlef, Vrontisi, Zoi, and Riahi, Keywan
- Published
- 2025
- Full Text
- View/download PDF
155. Proton imaging of high-energy-density laboratory plasmas
- Author
-
Schaeffer, Derek B, Bott, Archie FA, Borghesi, Marco, Flippo, Kirk A, Fox, William, Fuchs, Julien, Li, Chikang, Séguin, Fredrick H, Park, Hye-Sook, Tzeferacos, Petros, and Willingale, Louise
- Subjects
Nuclear and Plasma Physics ,Information and Computing Sciences ,Physical Sciences ,Bioengineering ,Affordable and Clean Energy ,Fluids & Plasmas ,Chemical sciences ,Engineering ,Physical sciences - Abstract
Proton imaging has become a key diagnostic for measuring electromagnetic fields in high-energy-density (HED) laboratory plasmas. Compared to other techniques for diagnosing fields, proton imaging is a measurement that can simultaneously offer high spatial and temporal resolution and the ability to distinguish between electric and magnetic fields without the protons perturbing the plasma of interest. Consequently, proton imaging has been used in a wide range of HED experiments, from inertial-confinement fusion to laboratory astrophysics. An overview is provided on the state of the art of proton imaging, including a discussion of experimental considerations like proton sources and detectors, the theory of proton-imaging analysis, and a survey of experimental results demonstrating the breadth of applications. Topics at the frontiers of proton-imaging development are also described, along with an outlook on the future of the field.
- Published
- 2023
156. Collectively enhanced Ramsey readout by cavity sub- to superradiant transition
- Author
-
Bohr, Eliot, Kristensen, Sofus L., Hotter, Christoph, Schäffer, Stefan Alaric, Robinson-Tait, Julian, Thomsen, Jan W., Zelevinsky, Tanya, Ritsch, Helmut, and Müller, Jörg Helge
- Subjects
Quantum Physics ,Physics - Atomic Physics - Abstract
When an inverted ensemble of atoms is tightly packed on the scale of its emission wavelength or when the atoms are collectively strongly coupled to a single cavity mode, their dipoles will align and decay rapidly via a superradiant burst. However, a spread-out dipole phase distribution theory predicts a required minimum threshold of atomic excitation for superradiance to occur. Here we experimentally confirm this predicted threshold for superradiant emission on a narrow optical transition when exciting the atoms transversely and show how to take advantage of the resulting sub- to superradiant transition. A $\pi/2$-pulse places the atoms in a subradiant state, protected from collective cavity decay, which we exploit during the free evolution period in a corresponding Ramsey pulse sequence. The final excited state population is read out via superradiant emission from the inverted atomic ensemble after a second $\pi/2$-pulse, and with minimal heating this allows for multiple Ramsey sequences within one experimental cycle. Our scheme is a fundamentally new approach to atomic state readout characterized by its speed, simplicity, and high sensitivity. It demonstrates the potential of sensors using collective effects in cavity-coupled quantum emitters., Comment: Removed a duplicate paragraph
- Published
- 2023
157. Hybrid Soft-Rigid Continuum Robot Inspired by Spider Monkey Tail
- Author
-
Doerfler, Mary C., Schäffer, Katalin, and Coad, Margaret M.
- Subjects
Computer Science - Robotics - Abstract
Spider monkeys (genus Ateles) have a prehensile tail that functions as a flexible, multipurpose fifth limb, enabling them to navigate complex terrains, grasp objects of various sizes, and swing between supports. Inspired by the spider monkey tail, we present a life size hybrid soft-rigid continuum robot designed to imitate the function of the tail. Our planar design has a rigid skeleton with soft elements at its joints that achieve decreasing stiffness along its length. Five manually-operated wires along this central structure control the motion of the tail to form a variety of possible shapes in the 2D plane. Our design also includes a skin-like silicone and fabric tail pad that moves with the tail's tip and assists with object grasping. We quantify the force required to pull various objects out of the robot's grasp and demonstrate that this force increases with the object diameter and the number of edges in a polygonal object. We demonstrate the robot's ability to grasp, move, and release objects of various diameters, as well as to navigate around obstacles, and to retrieve an object after passing under a low passageway., Comment: 6 pages, 8 figures. Published in 2023 IEEE International Conference on Soft Robotics (RoboSoft)
- Published
- 2023
- Full Text
- View/download PDF
158. DecodingTrust: A Comprehensive Assessment of Trustworthiness in GPT Models
- Author
-
Wang, Boxin, Chen, Weixin, Pei, Hengzhi, Xie, Chulin, Kang, Mintong, Zhang, Chenhui, Xu, Chejian, Xiong, Zidi, Dutta, Ritik, Schaeffer, Rylan, Truong, Sang T., Arora, Simran, Mazeika, Mantas, Hendrycks, Dan, Lin, Zinan, Cheng, Yu, Koyejo, Sanmi, Song, Dawn, and Li, Bo
- Subjects
Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computer Science - Cryptography and Security - Abstract
Generative Pre-trained Transformer (GPT) models have exhibited exciting progress in their capabilities, capturing the interest of practitioners and the public alike. Yet, while the literature on the trustworthiness of GPT models remains limited, practitioners have proposed employing capable GPT models for sensitive applications such as healthcare and finance -- where mistakes can be costly. To this end, this work proposes a comprehensive trustworthiness evaluation for large language models with a focus on GPT-4 and GPT-3.5, considering diverse perspectives -- including toxicity, stereotype bias, adversarial robustness, out-of-distribution robustness, robustness on adversarial demonstrations, privacy, machine ethics, and fairness. Based on our evaluations, we discover previously unpublished vulnerabilities to trustworthiness threats. For instance, we find that GPT models can be easily misled to generate toxic and biased outputs and leak private information in both training data and conversation history. We also find that although GPT-4 is usually more trustworthy than GPT-3.5 on standard benchmarks, GPT-4 is more vulnerable given jailbreaking system or user prompts, potentially because GPT-4 follows (misleading) instructions more precisely. Our work illustrates a comprehensive trustworthiness evaluation of GPT models and sheds light on the trustworthiness gaps. Our benchmark is publicly available at https://decodingtrust.github.io/ ; our dataset can be previewed at https://huggingface.co/datasets/AI-Secure/DecodingTrust ; a concise version of this work is at https://openreview.net/pdf?id=kaHpo8OZw2 ., Comment: NeurIPS 2023 Outstanding Paper (Datasets and Benchmarks Track)
- Published
- 2023
159. BEoRN: A fast and flexible framework to simulate the epoch of reionisation and cosmic dawn
- Author
-
Schaeffer, Timothée, Giri, Sambit K., and Schneider, Aurel
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
In this study, we introduce BEoRN (Bubbles during the Epoch of Reionisation Numerical Simulator), a publicly available Python code that generates three-dimensional maps of the 21-cm signal from the cosmic dawn and the epoch of reionisation. Built upon N-body simulation outputs, BEoRN populates haloes with stars and galaxies based on a flexible source model. It then computes the evolution of Lyman-$\alpha$ coupling, temperature, and ionisation profiles as a function of source properties, and paints these profiles around each source onto a three-dimensional grid. The code consistently deals with the overlap of ionised bubbles by redistributing photons around the bubble boundaries, thereby ensuring photon conservation. It accounts for the redshifting of photons and the source look-back effect for the temperature and Lyman-$\alpha$ coupling profiles which extend far into the intergalactic medium to scales of order 100 cMpc. We provide a detailed description of the code and compare it to results from the literature. After validation, we run three different benchmark models based on a cosmological N-body simulation. All three models agree with current observations from UV luminosity functions and estimates of the mean ionisation fraction. Due to different assumptions regarding the small-mass stellar-to-halo relation, the X-ray flux emission, and the ionising photon escape fraction, the models produce unique signatures ranging from a cold reionisation with deep absorption trough to an emission-dominated 21-cm signal, broadly encompassing the current uncertainties at cosmic dawn. The code BEoRN is publicly available at https://github.com/cosmic-reionization/BEoRN.
- Published
- 2023
- Full Text
- View/download PDF
160. Two-dimensional Thomson scattering in high-repetition-rate laser-plasma experiments
- Author
-
Zhang, H., Pilgram, J. J., Constantin, C. G., Rovige, L., Heuer, P. V., Ghazaryan, S., Kaloyan, M., Dorst, R. S., Schaeffer, D. B., and Niemann, C.
- Subjects
Physics - Instrumentation and Detectors ,Physics - Plasma Physics - Abstract
We present the first two-dimensional (2D) optical Thomson scattering measurements of electron density and temperature in laser-produced plasmas. The novel instrument directly measures $n_e(x,y)$ and $T_e(x,y)$ in two dimensions over large spatial regions (cm$^2$) with sub-mm spatial resolution, by automatically translating the scattering volume while the plasma is produced repeatedly by irradiating a solid target with a high-repetition-rate laser beam (10 J, $\sim$10$^{12}$ W/cm$^2$, 1 Hz). In this paper, we describe the design and auto-alignment of the instrument, and the computerized fitting algorithm of the spectral distribution function to large data-sets of measured scattering spectra, as they transition from the collective to the non-collective regime with distance from the target. As an example, we present 2D scattering measurements in laser driven shock waves in ambient nitrogen gas at a pressure of 95 mTorr., Comment: 8 pages, 4 figures
- Published
- 2023
- Full Text
- View/download PDF
161. Are Emergent Abilities of Large Language Models a Mirage?
- Author
-
Schaeffer, Rylan, Miranda, Brando, and Koyejo, Sanmi
- Subjects
Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Recent work claims that large language models display emergent abilities, abilities not present in smaller-scale models that are present in larger-scale models. What makes emergent abilities intriguing is two-fold: their sharpness, transitioning seemingly instantaneously from not present to present, and their unpredictability, appearing at seemingly unforeseeable model scales. Here, we present an alternative explanation for emergent abilities: that for a particular task and model family, when analyzing fixed model outputs, emergent abilities appear due to the researcher's choice of metric rather than due to fundamental changes in model behavior with scale. Specifically, nonlinear or discontinuous metrics produce apparent emergent abilities, whereas linear or continuous metrics produce smooth, continuous predictable changes in model performance. We present our alternative explanation in a simple mathematical model, then test it in three complementary ways: we (1) make, test and confirm three predictions on the effect of metric choice using the InstructGPT/GPT-3 family on tasks with claimed emergent abilities; (2) make, test and confirm two predictions about metric choices in a meta-analysis of emergent abilities on BIG-Bench; and (3) show to choose metrics to produce never-before-seen seemingly emergent abilities in multiple vision tasks across diverse deep networks. Via all three analyses, we provide evidence that alleged emergent abilities evaporate with different metrics or with better statistics, and may not be a fundamental property of scaling AI models.
- Published
- 2023
162. Automated robotic intraoperative ultrasound for brain surgery
- Author
-
Dyck, Michael, Weld, Alistair, Klodmann, Julian, Kirst, Alexander, Anichini, Giulio, Dixon, Luke, Camp, Sophie, Giannarou, Stamatia, and Albu-Schäffer, Alin
- Subjects
Computer Science - Robotics - Abstract
During brain tumour resection, localising cancerous tissue and delineating healthy and pathological borders is challenging, even for experienced neurosurgeons and neuroradiologists. Intraoperative imaging is commonly employed for determining and updating surgical plans in the operating room. Ultrasound (US) has presented itself a suitable tool for this task, owing to its ease of integration into the operating room and surgical procedure. However, widespread establishment of this tool has been limited because of the difficulty of anatomy localisation and data interpretation. In this work, we present a robotic framework designed and tested on a soft-tissue-mimicking brain phantom, simulating intraoperative US (iUS) scanning during brain tumour surgery.
- Published
- 2023
163. Einleitung
- Author
-
Schulz-Schaeffer, Ingo, Gajewski, Eltje, Kirschsieper, Dennis, Kleemann, Frank, Schulz-Schaeffer, Ingo, Gajewski, Eltje, Kirschsieper, Dennis, and Kleemann, Frank
- Published
- 2024
- Full Text
- View/download PDF
164. Falldarstellungen
- Author
-
Schulz-Schaeffer, Ingo, Gajewski, Eltje, Kirschsieper, Dennis, Kleemann, Frank, Schulz-Schaeffer, Ingo, Gajewski, Eltje, Kirschsieper, Dennis, and Kleemann, Frank
- Published
- 2024
- Full Text
- View/download PDF
165. Forschungsgegenstand, Forschungsstand und Analyserahmen
- Author
-
Schulz-Schaeffer, Ingo, Gajewski, Eltje, Kirschsieper, Dennis, Kleemann, Frank, Schulz-Schaeffer, Ingo, Gajewski, Eltje, Kirschsieper, Dennis, and Kleemann, Frank
- Published
- 2024
- Full Text
- View/download PDF
166. Vergleichende Auswertung der Fallstudien
- Author
-
Schulz-Schaeffer, Ingo, Gajewski, Eltje, Kirschsieper, Dennis, Kleemann, Frank, Schulz-Schaeffer, Ingo, Gajewski, Eltje, Kirschsieper, Dennis, and Kleemann, Frank
- Published
- 2024
- Full Text
- View/download PDF
167. Anlage der Untersuchung
- Author
-
Schulz-Schaeffer, Ingo, Gajewski, Eltje, Kirschsieper, Dennis, Kleemann, Frank, Schulz-Schaeffer, Ingo, Gajewski, Eltje, Kirschsieper, Dennis, and Kleemann, Frank
- Published
- 2024
- Full Text
- View/download PDF
168. Analyzing Distributed Action in the Making by Comparing Human-Robot Co-Work Scenarios
- Author
-
Schulz-Schaeffer, Ingo, Clausnitzer, Tim, Wiggert, Kevin, Meister, Martin, Pfeiffer, Sabine, editor, Nicklich, Manuel, editor, Henke, Michael, editor, Heßler, Martina, editor, Krzywdzinski, Martin, editor, and Schulz-Schaeffer, Ingo, editor
- Published
- 2024
- Full Text
- View/download PDF
169. Digitalisierung der Arbeitswelten. Eine systemische Transformation?
- Author
-
Pfeiffer, Sabine, Nicklich, Manuel, Michael, Henke, Martina, Heßler, Martin, Krzywdzinski, Ingo, Schulz-Schaeffer, Pfeiffer, Sabine, editor, Nicklich, Manuel, editor, Henke, Michael, editor, Heßler, Martina, editor, Krzywdzinski, Martin, editor, and Schulz-Schaeffer, Ingo, editor
- Published
- 2024
- Full Text
- View/download PDF
170. Prävention durch nicht-medikamentöse Maßnahmen
- Author
-
Knacke, Henrike, Schäffer, Eva, Knacke, Henrike, and Schäffer, Eva
- Published
- 2024
- Full Text
- View/download PDF
171. Die Prodromalphase – Risikofaktoren und Prodromalmarker
- Author
-
Knacke, Henrike, Schäffer, Eva, Knacke, Henrike, and Schäffer, Eva
- Published
- 2024
- Full Text
- View/download PDF
172. Pathophysiologische Grundlagen der Parkinsonkrankheit
- Author
-
Knacke, Henrike, Schäffer, Eva, Knacke, Henrike, and Schäffer, Eva
- Published
- 2024
- Full Text
- View/download PDF
173. Biomarker
- Author
-
Knacke, Henrike, Schäffer, Eva, Knacke, Henrike, and Schäffer, Eva
- Published
- 2024
- Full Text
- View/download PDF
174. Double Descent Demystified: Identifying, Interpreting & Ablating the Sources of a Deep Learning Puzzle
- Author
-
Schaeffer, Rylan, Khona, Mikail, Robertson, Zachary, Boopathy, Akhilan, Pistunova, Kateryna, Rocks, Jason W., Fiete, Ila Rani, and Koyejo, Oluwasanmi
- Subjects
Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
Double descent is a surprising phenomenon in machine learning, in which as the number of model parameters grows relative to the number of data, test error drops as models grow ever larger into the highly overparameterized (data undersampled) regime. This drop in test error flies against classical learning theory on overfitting and has arguably underpinned the success of large models in machine learning. This non-monotonic behavior of test loss depends on the number of data, the dimensionality of the data and the number of model parameters. Here, we briefly describe double descent, then provide an explanation of why double descent occurs in an informal and approachable manner, requiring only familiarity with linear algebra and introductory probability. We provide visual intuition using polynomial regression, then mathematically analyze double descent with ordinary linear regression and identify three interpretable factors that, when simultaneously all present, together create double descent. We demonstrate that double descent occurs on real data when using ordinary linear regression, then demonstrate that double descent does not occur when any of the three factors are ablated. We use this understanding to shed light on recent observations in nonlinear models concerning superposition and double descent. Code is publicly available.
- Published
- 2023
175. EigenMPC: An Eigenmanifold-Inspired Model-Predictive Control Framework for Exciting Efficient Oscillations in Mechanical Systems
- Author
-
Coelho, Andre, Albu-Schaeffer, Alin, Sachtler, Arne, Mishra, Hrishik, Bicego, Davide, Ott, Christian, and Franchi, Antonio
- Subjects
Computer Science - Robotics ,Electrical Engineering and Systems Science - Systems and Control - Abstract
This paper proposes a Nonlinear Model-Predictive Control (NMPC) method capable of finding and converging to energy-efficient regular oscillations, which require no control action to be sustained. The approach builds up on the recently developed Eigenmanifold theory, which defines the sets of line-shaped oscillations of a robot as an invariant two-dimensional submanifold of its state space. By defining the control problem as a nonlinear program (NLP), the controller is able to deal with constraints in the state and control variables and be energy-efficient not only in its final trajectory but also during the convergence phase. An initial implementation of this approach is proposed, analyzed, and tested in simulation.
- Published
- 2023
- Full Text
- View/download PDF
176. Principal blocks with six ordinary irreducible characters
- Author
-
Hung, Nguyen N., Fry, A. A. Schaeffer, and Vallejo, Carolina
- Subjects
Mathematics - Representation Theory ,Mathematics - Group Theory ,Primary 20C20, 20C15, 20C33 - Abstract
We classify Sylow $p$-subgroups of finite groups whose principal $p$-blocks have precisely six ordinary irreducible characters., Comment: 18 pages, 1 table. The second version includes comments from Gunter Malle
- Published
- 2023
177. Cosmological forecast of the 21-cm power spectrum using the halo model of reionization
- Author
-
Schneider, Aurel, Schaeffer, Timothée, and Giri, Sambit K.
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The 21-cm power spectrum of reionization is a promising probe for cosmology and fundamental physics. Exploiting this new observable, however, requires fast predictors capable of efficiently scanning the very large parameter space of cosmological and astrophysical uncertainties. In this paper, we introduce the halo model of reionization (HMreio), a new analytical tool that combines the halo model of the cosmic dawn with the excursion-set bubble model for reionization, assuming an empirical correction factor to deal with overlapping ionization bubbles. First, HMreio is validated against results from the well-known semi-numerical code 21cmFAST, showing a good overall agreement for wave-modes of $k\lesssim 1$ h/Mpc. Based on this result, we perform a Monte-Carlo Markov-Chain (MCMC) forecast analysis assuming mock data from 1000-hour observations with the low-frequency part of the Square Kilometre Array (SKA) observatory. We simultaneously vary the six standard cosmological parameters together with seven astrophysical nuisance parameters quantifying the abundance and spectral properties of sources. Depending on the assumed theory error, we find very competitive constraints on cosmological parameters. In particular, it will be possible to conclusively test current cosmological tensions related to the Hubble parameter ($H_0$-tension) and the matter clustering amplitude ($S_8$-tension). Furthermore, the sum of the neutrino masses can be strongly constrained, making it possible to determine the neutrino mass hierarchy at the $\sim 90$ percent confidence level. However, these goals can only be achieved if the current modelling uncertainties are substantially reduced to below $\sim 3$ percent., Comment: 18 pages, 8 figures, comments welcome
- Published
- 2023
178. Machine Learning Benchmarks for the Classification of Equivalent Circuit Models from Electrochemical Impedance Spectra
- Author
-
Schaeffer, Joachim, Gasper, Paul, Garcia-Tamayo, Esteban, Gasper, Raymond, Adachi, Masaki, Gaviria-Cardona, Juan Pablo, Montoya-Bedoya, Simon, Bhutani, Anoushka, Schiek, Andrew, Goodall, Rhys, Findeisen, Rolf, Braatz, Richard D., and Engelke, Simon
- Subjects
Computer Science - Machine Learning ,Condensed Matter - Materials Science ,68T10 - Abstract
Analysis of Electrochemical Impedance Spectroscopy (EIS) data for electrochemical systems often consists of defining an Equivalent Circuit Model (ECM) using expert knowledge and then optimizing the model parameters to deconvolute various resistance, capacitive, inductive, or diffusion responses. For small data sets, this procedure can be conducted manually; however, it is not feasible to manually define a proper ECM for extensive data sets with a wide range of EIS responses. Automatic identification of an ECM would substantially accelerate the analysis of large sets of EIS data. We showcase machine learning methods to classify the ECMs of 9,300 impedance spectra provided by QuantumScape for the BatteryDEV hackathon. The best-performing approach is a gradient-boosted tree model utilizing a library to automatically generate features, followed by a random forest model using the raw spectral data. A convolutional neural network using boolean images of Nyquist representations is presented as an alternative, although it achieves a lower accuracy. We publish the data and open source the associated code. The approaches described in this article can serve as benchmarks for further studies. A key remaining challenge is the identifiability of the labels, underlined by the model performances and the comparison of misclassified spectra., Comment: Manuscript: 17 pages, 9 figures; Supplementary Information: 9 pages, 6 figures
- Published
- 2023
- Full Text
- View/download PDF
179. Strong collisionless coupling between an unmagnetized driver plasma and a magnetized background plasma
- Author
-
Cruz, Filipe D., Schaeffer, Derek. B., Cruz, Fábio, and Silva, Luis O.
- Subjects
Physics - Plasma Physics - Abstract
Fast-exploding plasmas traveling though magnetized, collisionless plasmas can occur in a variety of physical systems, such as supernova remnants, coronal mass ejections, and laser-driven laboratory experiments. To study these systems, it is important to understand the coupling process between the plasmas. In this work, we develop a semi-analytical model of the parameters that characterize the strong collisionless coupling between an unmagnetized driver plasma and a uniformly and perpendicularly magnetized background plasma. In particular, we derive analytical expressions that describe the characteristic diamagnetic cavity and magnetic compression of these systems, such as their corresponding velocities, the compression ratio, and the maximum size of the cavity. The semi-analytical model is compared with collisionless 1D particle-in-cell simulations and experimental results with laser-driven plasmas, showing good agreement. The model allows us to provide bounds for parameters that are otherwise difficult to diagnose in experiments with similar setups.
- Published
- 2023
- Full Text
- View/download PDF
180. Collaborative Robotic Ultrasound Tissue Scanning for Surgical Resection Guidance in Neurosurgery
- Author
-
Weld, Alistair, Dyck, Michael, Klodmann, Julian, Anichini, Giulio, Dixon, Luke, Camp, Sophie, Albu-Schäffer, Alin, and Giannarou, Stamatia
- Subjects
Computer Science - Robotics ,Computer Science - Computer Vision and Pattern Recognition - Abstract
The aim of this paper is to introduce a robotic platform for autonomous iUS tissue scanning to optimise intraoperative diagnosis and improve surgical resection during robot-assisted operations. To guide anatomy specific robotic scanning and generate a representation of the robot task space, fast and accurate techniques for the recovery of 3D morphological structures of the surgical cavity are developed. The prototypic DLR MIRO surgical robotic arm is used to control the applied force and the in-plane motion of the US transducer. A key application of the proposed platform is the scanning of brain tissue to guide tumour resection.
- Published
- 2023
181. Use of the Decipher genomic classifier among men with prostate cancer in the United States.
- Author
-
Zaorsky, Nicholas, Proudfoot, James, Jia, Angela, Zuhour, Raed, Vince, Randy, Liu, Yang, Zhao, Xin, Hu, Jim, Schussler, Nicola, Stevens, Jennifer, Bentler, Suzanne, Cress, Rosemary, Doherty, Jennifer, Durbin, Eric, Gershman, Susan, Cheng, Iona, Gonsalves, Lou, Hernandez, Brenda, Liu, Lihua, Morawski, Bożena, Schymura, Maria, Schwartz, Stephen, Ward, Kevin, Wiggins, Charles, Wu, Xiao-Cheng, Shoag, Jonathan, Ponsky, Lee, Dal Pra, Alan, Schaeffer, Edward, Ross, Ashley, Sun, Yilun, Davicioni, Elai, Petkov, Valentina, and Spratt, Daniel
- Subjects
Male ,Humans ,United States ,Risk Assessment ,Prostatic Neoplasms ,Prostate-Specific Antigen ,Prostate ,Genomics - Abstract
BACKGROUND: Management of localized or recurrent prostate cancer since the 1990s has been based on risk stratification using clinicopathological variables, including Gleason score, T stage (based on digital rectal exam), and prostate-specific antigen (PSA). In this study a novel prognostic test, the Decipher Prostate Genomic Classifier (GC), was used to stratify risk of prostate cancer progression in a US national database of men with prostate cancer. METHODS: Records of prostate cancer cases from participating SEER (Surveillance, Epidemiology, and End Results) program registries, diagnosed during the period from 2010 through 2018, were linked to records of testing with the GC prognostic test. Multivariable analysis was used to quantify the association between GC scores or risk groups and use of definitive local therapy after diagnosis in the GC biopsy-tested cohort and postoperative radiotherapy in the GC-tested cohort as well as adverse pathological findings after prostatectomy. RESULTS: A total of 572 545 patients were included in the analysis, of whom 8927 patients underwent GC testing. GC biopsy-tested patients were more likely to undergo active active surveillance or watchful waiting than untested patients (odds ratio [OR] =2.21, 95% confidence interval [CI] = 2.04 to 2.38, P
- Published
- 2023
182. Prevalence of Symptoms ≤12 Months After Acute Illness, by COVID-19 Testing Status Among Adults - United States, December 2020-March 2023.
- Author
-
Ford, James, Yu, Huihui, Gottlieb, Michael, Morse, Dana, Santangelo, Michelle, OLaughlin, Kelli, Schaeffer, Kevin, Logan, Pamela, Rising, Kristin, Hill, Mandy, Wisk, Lauren, Salah, Wafah, Idris, Ahamed, Huebinger, Ryan, Spatz, Erica, Klabbers, Robin, Gatling, Kristyn, Wang, Ralph, Elmore, Joann, McDonald, Samuel, Stephens, Kari, Weinstein, Robert, Venkatesh, Arjun, Saydah, Sharon, Rodriguez, Robert, and Montoy, Juan Carlos
- Subjects
Adult ,Humans ,Acute Disease ,Cohort Studies ,COVID-19 ,COVID-19 Testing ,Post-Acute COVID-19 Syndrome ,Prevalence ,Prospective Studies ,SARS-CoV-2 ,United States - Abstract
To further the understanding of post-COVID conditions, and provide a more nuanced description of symptom progression, resolution, emergence, and reemergence after SARS-CoV-2 infection or COVID-like illness, analysts examined data from the Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE), a prospective multicenter cohort study. This report includes analysis of data on self-reported symptoms collected from 1,296 adults with COVID-like illness who were tested for SARS-CoV-2 using a Food and Drug Administration-approved polymerase chain reaction or antigen test at the time of enrollment and reported symptoms at 3-month intervals for 12 months. Prevalence of any symptom decreased substantially between baseline and the 3-month follow-up, from 98.4% to 48.2% for persons who received a positive SARS-CoV-2 test results (COVID test-positive participants) and from 88.2% to 36.6% for persons who received negative SARS-CoV-2 test results (COVID test-negative participants). Persistent symptoms decreased through 12 months; no difference between the groups was observed at 12 months (prevalence among COVID test-positive and COVID test-negative participants = 18.3% and 16.1%, respectively; p>0.05). Both groups reported symptoms that emerged or reemerged at 6, 9, and 12 months. Thus, these symptoms are not unique to COVID-19 or to post-COVID conditions. Awareness that symptoms might persist for up to 12 months, and that many symptoms might emerge or reemerge in the year after COVID-like illness, can assist health care providers in understanding the clinical signs and symptoms associated with post-COVID-like conditions.
- Published
- 2023
183. Artificial Intelligence Predictive Model for Hormone Therapy Use in Prostate Cancer.
- Author
-
Spratt, Daniel, Tang, Siyi, Sun, Yilun, Huang, Huei-Chung, Chen, Emmalyn, Mohamad, Osama, Armstrong, Andrew, Tward, Jonathan, Nguyen, Paul, Lang, Joshua, Zhang, Jingbin, Mitani, Akinori, Simko, Jeffry, DeVries, Sandy, van der Wal, Douwe, Pinckaers, Hans, Monson, Jedidiah, Campbell, Holly, Wallace, James, Ferguson, Michelle, Bahary, Jean-Paul, Schaeffer, Edward, Sandler, Howard, Tran, Phuoc, Rodgers, Joseph, Esteva, Andre, Yamashita, Rikiya, and Feng, Felix
- Subjects
Male ,Humans ,Prostatic Neoplasms ,Androgen Antagonists ,Prostate-Specific Antigen ,Artificial Intelligence ,Hormones - Abstract
BACKGROUND: Androgen deprivation therapy (ADT) with radiotherapy can benefit patients with localized prostate cancer. However, ADT can negatively impact quality of life, and there remain no validated predictive models to guide its use. METHODS: We used digital pathology images from pretreatment prostate tissue and clinical data from 5727 patients enrolled in five phase 3 randomized trials, in which treatment was radiotherapy with or without ADT, as our data source to develop and validate an artificial intelligence (AI)–derived predictive patient-specific model that would determine which patients would develop the primary end point of distant metastasis. The model used baseline data to provide a binary output that a given patient will likely benefit from ADT or not. After the model was locked, validation was performed using data from NRG Oncology/Radiation Therapy Oncology Group (RTOG) 9408 (n=1594), a trial that randomly assigned men to radiotherapy plus or minus 4 months of ADT. Fine–Gray regression and restricted mean survival times were used to assess the interaction between treatment and the predictive model and within predictive model–positive, i.e., benefited from ADT, and –negative subgroup treatment effects. RESULTS: Overall, in the NRG/RTOG 9408 validation cohort (14.9 years of median follow-up), ADT significantly improved time to distant metastasis. Of these enrolled patients, 543 (34%) were model positive, and ADT significantly reduced the risk of distant metastasis compared with radiotherapy alone. Of 1051 patients who were model negative, ADT did not provide benefit. CONCLUSIONS: Our AI-based predictive model was able to identify patients with a predominantly intermediate risk for prostate cancer likely to benefit from short-term ADT. (Supported by a grant [U10CA180822] from NRG Oncology Statistical and Data Management Center, a grant [UG1CA189867] from NCI Community Oncology Research Program, a grant [U10CA180868] from NRG Oncology Operations, and a grant [U24CA196067] from NRG Specimen Bank from the National Cancer Institute and by Artera, Inc. ClinicalTrials.gov numbers NCT00767286, NCT00002597, NCT00769548, NCT00005044, and NCT00033631.)
- Published
- 2023
184. A novel prostate cancer subtyping classifier based on luminal and basal phenotypes
- Author
-
Weiner, Adam B, Liu, Yang, Hakansson, Alex, Zhao, Xin, Proudfoot, James A, Ho, Julian, Zhang, Jj H, Li, Eric V, Karnes, R Jeffrey, Den, Robert B, Kishan, Amar U, Reiter, Robert E, Hamid, Anis A, Ross, Ashely E, Tran, Phuoc T, Davicioni, Elai, Spratt, Daniel E, Attard, Gerhardt, Lotan, Tamara L, Lee Kiang Chua, Melvin, Sweeney, Christopher J, and Schaeffer, Edward M
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Prostate Cancer ,Aging ,Genetics ,Clinical Research ,Urologic Diseases ,2.1 Biological and endogenous factors ,Aetiology ,Humans ,Male ,Prostatic Neoplasms ,Receptors ,Androgen ,Docetaxel ,Androgen Antagonists ,Gene Expression Profiling ,Phenotype ,Biomarkers ,Tumor ,Prognosis ,biomarkers ,gene expression ,gene expression profiling ,genetics ,humans ,pathology ,prognosis ,prostatic neoplasms ,tumor ,Public Health and Health Services ,Oncology & Carcinogenesis ,Oncology and carcinogenesis ,Public health - Abstract
BackgroundProstate cancer (PCa) is a clinically heterogeneous disease. The creation of an expression-based subtyping model based on prostate-specific biological processes was sought.MethodsUnsupervised machine learning of gene expression profiles from prospectively collected primary prostate tumors (training, n = 32,000; evaluation, n = 68,547) was used to create a prostate subtyping classifier (PSC) based on basal versus luminal cell expression patterns and other gene signatures relevant to PCa biology. Subtype molecular pathways and clinical characteristics were explored in five other clinical cohorts.ResultsClustering derived four subtypes: luminal differentiated (LD), luminal proliferating (LP), basal immune (BI), and basal neuroendocrine (BN). LP and LD tumors both had higher androgen receptor activity. LP tumors also had a higher expression of cell proliferation genes, MYC activity, and characteristics of homologous recombination deficiency. BI tumors possessed significant interferon γactivity and immune infiltration on immunohistochemistry. BN tumors were characterized by lower androgen receptor activity expression, lower immune infiltration, and enrichment with neuroendocrine expression patterns. Patients with LD tumors had less aggressive tumor characteristics and the longest time to metastasis after surgery. Only patients with BI tumors derived benefit from radiotherapy after surgery in terms of time to metastasis (hazard ratio [HR], 0.09; 95% CI, 0.01-0.71; n = 855). In a phase 3 trial that randomized patients with metastatic PCa to androgen deprivation with or without docetaxel (n = 108), only patients with LP tumors derived survival benefit from docetaxel (HR, 0.21; 95% CI, 0.09-0.51).ConclusionsWith the use of expression profiles from over 100,000 tumors, a PSC was developed that identified four subtypes with distinct biological and clinical features.Plain language summaryProstate cancer can behave in an indolent or aggressive manner and vary in how it responds to certain treatments. To differentiate prostate cancer on the basis of biological features, we developed a novel RNA signature by using data from over 100,000 prostate tumors-the largest data set of its kind. This signature can inform patients and physicians on tumor aggressiveness and susceptibilities to treatments to help personalize cancer management.
- Published
- 2023
185. Gesundheitskompetenz fördern
- Author
-
Schaeffer, Doris, Griese, Lennert, and Hurrelmann, Klaus
- Published
- 2024
- Full Text
- View/download PDF
186. International shipping in a world below 2 °C
- Author
-
Müller-Casseres, Eduardo, Leblanc, Florian, van den Berg, Maarten, Fragkos, Panagiotis, Dessens, Olivier, Naghash, Hesam, Draeger, Rebecca, Le Gallic, Thomas, Tagomori, Isabela S., Tsiropoulos, Ioannis, Emmerling, Johannes, Baptista, Luiz Bernardo, van Vuuren, Detlef P., Giannousakis, Anastasis, Drouet, Laurent, Portugal-Pereira, Joana, de Boer, Harmen-Sytze, Tsanakas, Nikolaos, Rochedo, Pedro R. R., Szklo, Alexandre, and Schaeffer, Roberto
- Published
- 2024
- Full Text
- View/download PDF
187. SRMD: Sparse Random Mode Decomposition
- Author
-
Richardson, Nicholas, Schaeffer, Hayden, and Tran, Giang
- Published
- 2024
- Full Text
- View/download PDF
188. Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers
- Author
-
Ferretti, Stephane, Hamon, Jacques, de Kanter, Ruben, Scheufler, Clemens, Andraos-Rey, Rita, Barbe, Stephanie, Bechter, Elisabeth, Blank, Jutta, Bordas, Vincent, Dammassa, Ernesta, Decker, Andrea, Di Nanni, Noemi, Dourdoigne, Marion, Gavioli, Elena, Hattenberger, Marc, Heuser, Alisa, Hemmerlin, Christelle, Hinrichs, Jürgen, Kerr, Grainne, Laborde, Laurent, Jaco, Isabel, Núñez, Eloísa Jiménez, Martus, Hans-Joerg, Quadt, Cornelia, Reschke, Markus, Romanet, Vincent, Schaeffer, Fanny, Schoepfer, Joseph, Schrapp, Maxime, Strang, Ross, Voshol, Hans, Wartmann, Markus, Welly, Sarah, Zécri, Frédéric, Hofmann, Francesco, Möbitz, Henrik, and Cortés-Cros, Marta
- Published
- 2024
- Full Text
- View/download PDF
189. Study on velocity fields of H2 during water electrolysis with KOH electrolyte comprising ionic liquid
- Author
-
Ferasso, Clauber André, de Oliveira, Jeferson Diehl, and Schaeffer, Lirio
- Published
- 2024
- Full Text
- View/download PDF
190. Assessment of machine learning strategies for simplified detection of autism spectrum disorder based on the gut microbiome composition
- Author
-
Olaguez-Gonzalez, Juan M., Schaeffer, S. Elisa, Breton-Deval, Luz, Alfaro-Ponce, Mariel, and Chairez, Isaac
- Published
- 2024
- Full Text
- View/download PDF
191. Gesundheitskompetenz — mehr als Gesundheitswissen!: 2. Jahrestagung des DNGK am 6. und 7. Juni 2024 an der Hochschule Fulda
- Author
-
Rathmann, Katharina, Bitzer, Eva-Maria, Dierks, Marie-Luise, Jordan, Susanne, Dadaczynski, Kevin, Orkan, Orkan, Schaeffer, Doris, and Schaefer, Corinna
- Published
- 2024
- Full Text
- View/download PDF
192. Utility of dynamic contrast enhancement for clinically significant prostate cancer detection
- Author
-
Eric V. Li, Sai K. Kumar, Jonathan A. Aguiar, Mohammad R. Siddiqui, Clayton Neill, Zequn Sun, Edward M. Schaeffer, Anugayathri Jawahar, Ashley E. Ross, and Hiten D. Patel
- Subjects
diagnosis ,dynamic contrast enhancement ,nomogram ,prostate cancer ,prostate MRI ,risk stratification ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Objective This study aimed to evaluate the association of dynamic contrast enhancement (DCE) with clinically significant prostate cancer (csPCa, Gleason Grade Group ≥2) and compare biparametric magnetic resonance imaging (bpMRI) and multiparametric MRI (mpMRI) nomograms. Subjects/patients and methods We identified a retrospective cohort of biopsy naïve patients who underwent pre‐biopsy MRI separated by individual MRI series from 2018 to 2022. csPCa detection rates were calculated for patients with peripheral zone (PZ) lesions scored 3–5 on diffusion weighted imaging (DWI) with available DCE (annotated as − or +). bpMRI Prostate Imaging Reporting and Data System (PIRADS) (3 = 3−, 3+; 4 = 4−, 4+; 5 = 5−, 5+) and mpMRI PIRADS (3 = 3−; 4 = 3+, 4−, 4+; 5 = 5−, 5+) approaches were compared in multivariable logistic regression models. Nomograms for detection of csPCa and ≥GG3 PCa incorporating all biopsy naïve patients who underwent prostate MRI were generated based on available serum biomarkers [PHI, % free prostate‐specific antigen (PSA), or total PSA] and validated with an independent cohort. Results Patients (n = 1010) with highest PIRADS lesion in PZ were included in initial analysis with 127 (12.6%) classified as PIRADS 3+ (PIRADS 3 on bpMRI but PIRADS 4 on mpMRI). On multivariable analysis, PIRADS 3+ lesions were associated with higher csPCa rates compared to PIRADS 3− (3+ vs. 3−: OR 1.86, p = 0.024), but lower csPCa rates compared to PIRADS DWI 4 lesions (4 vs. 3+: OR 2.39, p
- Published
- 2024
- Full Text
- View/download PDF
193. Evaluation of the efficacy of a live Escherichia coli biotherapeutic product (asymptomatic bacteriuria E. coli 212)
- Author
-
Gilad Segev, Hilla Chen, Jonathan D. Dear, Beatriz Martínez López, Jully Pires, David J. Klumpp, Anthony J. Schaeffer, and Jodi L. Westropp
- Subjects
antimicrobial resistance ,cystitis ,dog ,urinary tract ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Background Recurrent bacterial cystitis, often referred to as recurrent urinary tract infection (UTI), can be difficult to manage and alternative treatments are needed. Hypothesis/Objective Intravesicular administration of asymptomatic bacteriuria (ASB) E. coli 212 will not be inferior to antimicrobial treatment for the management of recurrent UTI in dogs. Animals Thirty‐four dogs with >1 UTI in the 12 months before presentation. Methods All dogs were deemed normal otherwise based on absence of abnormalities on physical examination, CBC, serum biochemical panel, and abdominal ultrasonography. Dogs were randomized to 1 of 2 treatment groups: Group 1 antimicrobials for 7 days or group 2 intravesicular administration of ASB E. coli 212. Owners were provided a voiding questionnaire regarding their dogs' clinical signs, which was completed daily for 14 days to assess clinical cure. Dogs were examined on days 7 and 14 to assess clinical cure, and urine specimens were submitted for urinalysis and bacterial culture. Results Clinical cure rates for ASB E. coli 212–treated dogs were not inferior to 7 days of antimicrobial treatment with a 12% margin of difference to determine non‐inferiority. No significant difference was found between the treatment groups on days 7 and 14 in the proportion of dogs achieving ≥50% or ≥75% reduction in their clinical score compared with baseline. Conclusions and Clinical Importance These data suggest that intravesicular administration of ASB E. coli 212 is not inferior to antimicrobials for the treatment of recurrent UTI in dogs. This biotherapeutic agent could help alleviate the need for antimicrobials for some dogs with recurrent UTI, improving antimicrobial stewardship.
- Published
- 2024
- Full Text
- View/download PDF
194. Transperineal Versus Transrectal Magnetic Resonance Imaging–targeted and Systematic Prostate Biopsy to Prevent Infectious Complications: The PREVENT Randomized Trial
- Author
-
Hu, Jim C., Assel, Melissa, Allaf, Mohamad E., Ehdaie, Behfar, Vickers, Andrew J., Cohen, Andrew J., Ristau, Benjamin T., Green, David A., Han, Misop, Rezaee, Michael E., Pavlovich, Christian P., Montgomery, Jeffrey S., Kowalczyk, Keith J., Ross, Ashley E., Kundu, Shilajit D., Patel, Hiten D., Wang, Gerald J., Graham, John N., Shoag, Jonathan E., Ghazi, Ahmed, Singla, Nirmish, Gorin, Michael A., Schaeffer, Anthony J., and Schaeffer, Edward M.
- Published
- 2024
- Full Text
- View/download PDF
195. Proton Imaging of High-Energy-Density Laboratory Plasmas
- Author
-
Schaeffer, Derek B., Bott, Archie F. A., Borghesi, Marco, Flippo, Kirk A., Fox, William, Fuchs, Julien, Li, Chikang, Park, Hye-Sook, Seguin, Fredrick H., Tzeferacos, Petros, and Willingale, Louise
- Subjects
Physics - Plasma Physics - Abstract
Proton imaging has become a key diagnostic for measuring electromagnetic fields in high-energy-density (HED) laboratory plasmas. Compared to other techniques for diagnosing fields, proton imaging is a non-perturbative measurement that can simultaneously offer high spatial and temporal resolution and the ability to distinguish between electric and magnetic fields. Consequently, proton imaging has been used in a wide range of HED experiments, from inertial confinement fusion to laboratory astrophysics. An overview is provided on the state of the art of proton imaging, including detailed discussion of experimental considerations like proton sources and detectors, the theory of proton-imaging analysis, and a survey of experimental results demonstrating the breadth of applications. Topics at the frontiers of proton imaging development are also described, along with an outlook on the future of the field.
- Published
- 2022
196. BelNet: Basis enhanced learning, a mesh-free neural operator
- Author
-
Zhang, Zecheng, Leung, Wing Tat, and Schaeffer, Hayden
- Subjects
Mathematics - Numerical Analysis - Abstract
Operator learning trains a neural network to map functions to functions. An ideal operator learning framework should be mesh-free in the sense that the training does not require a particular choice of discretization for the input functions, allows for the input and output functions to be on different domains, and is able to have different grids between samples. We propose a mesh-free neural operator for solving parametric partial differential equations. The basis enhanced learning network (BelNet) projects the input function into a latent space and reconstructs the output functions. In particular, we construct part of the network to learn the ``basis'' functions in the training process. This generalized the networks proposed in Chen and Chen's universal approximation theory for the nonlinear operators to account for differences in input and output meshes. Through several challenging high-contrast and multiscale problems, we show that our approach outperforms other operator learning methods for these tasks and allows for more freedom in the sampling and/or discretization process.
- Published
- 2022
197. Random Feature Models for Learning Interacting Dynamical Systems
- Author
-
Liu, Yuxuan, McCalla, Scott G., and Schaeffer, Hayden
- Subjects
Computer Science - Machine Learning ,Mathematics - Numerical Analysis ,Statistics - Machine Learning - Abstract
Particle dynamics and multi-agent systems provide accurate dynamical models for studying and forecasting the behavior of complex interacting systems. They often take the form of a high-dimensional system of differential equations parameterized by an interaction kernel that models the underlying attractive or repulsive forces between agents. We consider the problem of constructing a data-based approximation of the interacting forces directly from noisy observations of the paths of the agents in time. The learned interaction kernels are then used to predict the agents behavior over a longer time interval. The approximation developed in this work uses a randomized feature algorithm and a sparse randomized feature approach. Sparsity-promoting regression provides a mechanism for pruning the randomly generated features which was observed to be beneficial when one has limited data, in particular, leading to less overfitting than other approaches. In addition, imposing sparsity reduces the kernel evaluation cost which significantly lowers the simulation cost for forecasting the multi-agent systems. Our method is applied to various examples, including first-order systems with homogeneous and heterogeneous interactions, second order homogeneous systems, and a new sheep swarming system.
- Published
- 2022
- Full Text
- View/download PDF
198. On some rational extension properties for $GL_n(q)$ and even-degree characters fixed by order-2 Galois automorphisms
- Author
-
Fry, A. A. Schaeffer
- Subjects
Mathematics - Group Theory ,Mathematics - Representation Theory - Abstract
In this note, we prove that if every character of a finite group $G$ fixed by an order-2 Galois automorphism has odd degree, then $G$ has a normal Sylow $2$-subgroup. On the way, we study extensions of characters of $GL_n(q)$, $q$ odd, to the group extended by the transpose-inverse automorphism and prove that unipotent characters of $PSL_n(q)$ extend to rational characters of its automorphism group., Comment: Thm. A, Cor. B, are incorrect as stated and would require additional assumptions on q (a result of a missing assumption in another paper). Withdrawn until I obtain a working solution
- Published
- 2022
199. Navarro's Galois-McKay conjecture for the prime 2
- Author
-
Ruhstorfer, L. and Fry, A. A. Schaeffer
- Subjects
Mathematics - Representation Theory ,Mathematics - Group Theory - Abstract
We complete the proof of the McKay--Navarro conjecture (also known as the Galois--McKay conjecture) for the prime 2, by completing the proof of the inductive McKay--Navarro conditions introduced by Navarro--Sp\"ath--Vallejo in this situation.
- Published
- 2022
200. Sample-optimal classical shadows for pure states
- Author
-
Grier, Daniel, Pashayan, Hakop, and Schaeffer, Luke
- Subjects
Quantum Physics ,Computer Science - Information Theory ,Computer Science - Machine Learning - Abstract
We consider the classical shadows task for pure states in the setting of both joint and independent measurements. The task is to measure few copies of an unknown pure state $\rho$ in order to learn a classical description which suffices to later estimate expectation values of observables. Specifically, the goal is to approximate $\mathrm{Tr}(O \rho)$ for any Hermitian observable $O$ to within additive error $\epsilon$ provided $\mathrm{Tr}(O^2)\leq B$ and $\lVert O \rVert = 1$. Our main result applies to the joint measurement setting, where we show $\tilde{\Theta}(\sqrt{B}\epsilon^{-1} + \epsilon^{-2})$ samples of $\rho$ are necessary and sufficient to succeed with high probability. The upper bound is a quadratic improvement on the previous best sample complexity known for this problem. For the lower bound, we see that the bottleneck is not how fast we can learn the state but rather how much any classical description of $\rho$ can be compressed for observable estimation. In the independent measurement setting, we show that $\mathcal O(\sqrt{Bd} \epsilon^{-1} + \epsilon^{-2})$ samples suffice. Notably, this implies that the random Clifford measurements algorithm of Huang, Kueng, and Preskill, which is sample-optimal for mixed states, is not optimal for pure states. Interestingly, our result also uses the same random Clifford measurements but employs a different estimator., Comment: 34 pages; v2 - journal version
- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.