151. In vitro and sensory tests to design easy-to-swallow multi-particulate formulations
- Author
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Marco Marconati, Catherine Tuleu, Mine Orlu, Marco Ramaioli, and Felipe L. Lopez
- Subjects
Flexible dosing ,Adult ,Male ,Drug Compounding ,Pharmaceutical Science ,02 engineering and technology ,In Vitro Techniques ,030226 pharmacology & pharmacy ,Models, Biological ,Dosage form ,In vitro model ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Drug Delivery Systems ,Swallowing ,Sensory tests ,Humans ,Colloids ,Particle Size ,Tissues and Organs (q-bio.TO) ,Cellulose ,Drug Implants ,Chemistry ,Viscosity ,digestive, oral, and skin physiology ,Water ,Quantitative Biology - Tissues and Organs ,021001 nanoscience & nanotechnology ,Healthy Volunteers ,Deglutition ,Key factors ,FOS: Biological sciences ,Drug Design ,Taste ,SUSPENDING VEHICLE ,Female ,0210 nano-technology ,Rheology ,Oral retinoid ,Biomedical engineering - Abstract
Flexible dosing and ease of swallowing are key factors when designing oral drug delivery systems for paediatric and geriatric populations. Multi-particulate oral dosage forms can offer significant benefits over conventional capsules and tablets. This study proposes the use of an in vitro model to quantitatively investigate the swallowing dynamics in presence of multi-particulates. In vitro results were compared against sensory tests that considered the attributes of ease of swallowing and post-swallow residues. Water and hydrocolloids were considered as suspending vehicles, while the suspended phase consisted of cellulose pellets of two different average sizes. Both in vivo and in vitro tests reported easier swallow for smaller multi-particulates. Besides, water thin liquids appeared not optimal for complete oral clearance of the solids. The sensory study did not highlight significant differences between the levels of thickness of the hydrocolloids. Conversely, more discriminant results were obtained from in vitro tests, suggesting that a minimum critical viscosity is necessary to enable a smooth swallow, but increasing too much the carrier concentration affects swallowing negatively. These results highlight the important interplay of particle size and suspending vehicle rheology and the meaningful contribution that in vitro methods can provide to pre-screening multi-particulate oral drug delivery systems before sensory evaluation.
- Published
- 2018