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11,599 results on '"Shen, Yang"'

151. Data-Driven and Effective Teaching Action

Author

Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, Zeng, Haijun, Huang, Ronghuai, Series Editor, Kinshuk, Series Editor, Jemni, Mohamed, Series Editor, Chen, Nian-Shing, Series Editor, Spector, J. Michael, Series Editor, Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, and Zeng, Haijun

Published
2023
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153. All Round Coverage of Big Data Systems

Author

Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, Zeng, Haijun, Huang, Ronghuai, Series Editor, Kinshuk, Series Editor, Jemni, Mohamed, Series Editor, Chen, Nian-Shing, Series Editor, Spector, J. Michael, Series Editor, Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, and Zeng, Haijun

Published
2023
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154. Urban and Rural Assistance, Across the Straits

Author

Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, Zeng, Haijun, Huang, Ronghuai, Series Editor, Kinshuk, Series Editor, Jemni, Mohamed, Series Editor, Chen, Nian-Shing, Series Editor, Spector, J. Michael, Series Editor, Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, and Zeng, Haijun

Published
2023
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155. Thinking About the Digital Innovation Lab

Author

Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, Zeng, Haijun, Huang, Ronghuai, Series Editor, Kinshuk, Series Editor, Jemni, Mohamed, Series Editor, Chen, Nian-Shing, Series Editor, Spector, J. Michael, Series Editor, Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, and Zeng, Haijun

Published
2023
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156. Information Technology: Let Students Discover Their Beauty

Author

Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, Zeng, Haijun, Huang, Ronghuai, Series Editor, Kinshuk, Series Editor, Jemni, Mohamed, Series Editor, Chen, Nian-Shing, Series Editor, Spector, J. Michael, Series Editor, Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, and Zeng, Haijun

Published
2023
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157. Disciplines Are Fully Covered by Mobile Terminals

Author

Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, Zeng, Haijun, Huang, Ronghuai, Series Editor, Kinshuk, Series Editor, Jemni, Mohamed, Series Editor, Chen, Nian-Shing, Series Editor, Spector, J. Michael, Series Editor, Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, and Zeng, Haijun

Published
2023
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158. 'Data' Runs: in Smart Classrooms, Teachers and Teaching

Author

Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, Zeng, Haijun, Huang, Ronghuai, Series Editor, Kinshuk, Series Editor, Jemni, Mohamed, Series Editor, Chen, Nian-Shing, Series Editor, Spector, J. Michael, Series Editor, Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, and Zeng, Haijun

Published
2023
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162. A New Way of Informatization for Poor Schools of Ethnic Minorities

Author

Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, Zeng, Haijun, Huang, Ronghuai, Series Editor, Kinshuk, Series Editor, Jemni, Mohamed, Series Editor, Chen, Nian-Shing, Series Editor, Spector, J. Michael, Series Editor, Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, and Zeng, Haijun

Published
2023
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164. The Four Rules of Normalization of 'Internet +' Teaching

Author

Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, Zeng, Haijun, Huang, Ronghuai, Series Editor, Kinshuk, Series Editor, Jemni, Mohamed, Series Editor, Chen, Nian-Shing, Series Editor, Spector, J. Michael, Series Editor, Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, and Zeng, Haijun

Published
2023
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165. Diverse Star-Rating Online Review

Author

Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, Zeng, Haijun, Huang, Ronghuai, Series Editor, Kinshuk, Series Editor, Jemni, Mohamed, Series Editor, Chen, Nian-Shing, Series Editor, Spector, J. Michael, Series Editor, Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, and Zeng, Haijun

Published
2023
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166. Walk into the 'Internet + Subjects' Classroom

Author

Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, Zeng, Haijun, Huang, Ronghuai, Series Editor, Kinshuk, Series Editor, Jemni, Mohamed, Series Editor, Chen, Nian-Shing, Series Editor, Spector, J. Michael, Series Editor, Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, and Zeng, Haijun

Published
2023
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168. A New Educational Model of 'Classified Classes Online'

Author

Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, Zeng, Haijun, Huang, Ronghuai, Series Editor, Kinshuk, Series Editor, Jemni, Mohamed, Series Editor, Chen, Nian-Shing, Series Editor, Spector, J. Michael, Series Editor, Shen, Yang, Yin, Xin, Jiang, Yu, Kong, Lingkai, Li, Sheng, and Zeng, Haijun

Published
2023
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170. CCR5 closes the temporal window for memory linking

Author

Shen, Yang, Zhou, Miou, Cai, Denise, Filho, Daniel Almeida, Fernandes, Giselle, Cai, Ying, de Sousa, André F, Tian, Min, Kim, Nury, Lee, Jinsu, Necula, Deanna, Zhou, Chengbin, Li, Shuoyi, Salinas, Shelbi, Liu, Andy, Kang, Xiaoman, Kamata, Masakazu, Lavi, Ayal, Huang, Shan, Silva, Tawnie, Do Heo, Won, and Silva, Alcino J

Subjects
Neurosciences, Mental Health, Biotechnology, Neurological, Animals, CA1 Region, Hippocampal, Memory, Mental Recall, Mice, Neurons, Receptors, CCR5, Time Factors, General Science & Technology
Abstract

Real-world memories are formed in a particular context and are often not acquired or recalled in isolation1-5. Time is a key variable in the organization of memories, as events that are experienced close in time are more likely to be meaningfully associated, whereas those that are experienced with a longer interval are not1-4. How the brain segregates events that are temporally distinct is unclear. Here we show that a delayed (12-24 h) increase in the expression of C-C chemokine receptor type 5 (CCR5)-an immune receptor that is well known as a co-receptor for HIV infection6,7-after the formation of a contextual memory determines the duration of the temporal window for associating or linking that memory with subsequent memories. This delayed expression of CCR5 in mouse dorsal CA1 neurons results in a decrease in neuronal excitability, which in turn negatively regulates neuronal memory allocation, thus reducing the overlap between dorsal CA1 memory ensembles. Lowering this overlap affects the ability of one memory to trigger the recall of the other, and therefore closes the temporal window for memory linking. Our findings also show that an age-related increase in the neuronal expression of CCR5 and its ligand CCL5 leads to impairments in memory linking in aged mice, which could be reversed with a Ccr5 knockout and a drug approved by the US Food and Drug Administration (FDA) that inhibits this receptor, a result with clinical implications. Altogether, the findings reported here provide insights into the molecular and cellular mechanisms that shape the temporal window for memory linking.

Published
2022

199. Development of nomograms for predicting the survival of intestinal-type gastric adenocarcinoma patients after surgery

Author

Chu-Yun Liu, Yu-Shen Yang, Kai Ye, and He-fan He

Subjects
Medicine, Science
Abstract

Abstract Intestinal-type gastric adenocarcinoma (IGA) is a common phenotype of gastric cancer. Currently, few studies have constructed nomograms that may predict overall (OS) and cancer-specific survival (CSS) probability after surgery. This study is to establish novel nomograms for predicting the survival of IGA patients who received surgery. A total of 1814 IGA patients who received surgery between 2000 and 2018 were selected from Surveillance, Epidemiology, and End Results database and randomly assigned to the training and validating sets at a ratio of 7:3. Then univariate and multivariate cox regression analyses were performed to screen significant indictors for the construction of nomograms. The calibration curve, the area under the receiver operating characteristic (receiver operating characteristic, ROC) curve (the area under curve, AUC), C-index, net reclassification index (NRI), integrated discrimination improvement (IDI) and decision curve analysis (DCA) curves were applied to assess the performance of the model. The significant outcomes of multivariate analysis revealed that ten variables (age, sex, race, surgery type, summary stage, grade, AJCC TNM stage, radiotherapy, number of regional nodes examined, number of regional nodes positive) were demonstrated to construct the nomogram for OS and ten variables (age, sex, race, surgery type, summary stage, grade, AJCC TNM stage, chemotherapy, number of regional nodes examined, number of regional nodes positive) for CSS. The calibration and AUC uncovered their favorable predictive performance. Subsequently, C-index, NRI, IDI and DCA curves further validated the predicative superiority of nomograms over 7th AJCC Stage System. The validated nomogram provides more reliable OS and CSS predictions for postoperative IGA patients with good accuracy, which can help surgeons in treatment decision-making and prognosis evaluation.

Published
2023
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200. Pediatric adrenocortical carcinoma: clinical features and application of neoadjuvant chemotherapy

Author

Yu Lin, Shen Yang, Wei Yang, Haiyan Cheng, Xiaofeng Chang, Zhiyun Zhu, Jun Feng, Jianyu Han, Qinghua Ren, Saishuo Chang, Shan Liu, Tong Yu, Boren Hou, Pengfei Li, Deguang Meng, Xianwei Zhang, Hong Qin, and Huanmin Wang

Subjects
Children, Adrenal cortical carcinoma, Neoadjuvant chemotherapy, Clinical features, Prognosis, Medicine
Abstract

Abstract Objective To summarize the clinical characteristics of children with adrenocortical carcinoma (ACC) and preliminarily explore the indications for and efficacy of neoadjuvant chemotherapy in certain patients. Methods The data of 49 children with adrenocortical tumors (ACT) in the past 15 years were retrospectively analyzed, and after pathology assessment using Weiss system grading, 40 children diagnosed with ACC were included. Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 and three-dimensional (3D) reconstruction of contrast-enhanced computed tomography data were used to evaluate the response to neoadjuvant chemotherapy. Results Forty patients (17 males, 23 females) with ACC were enrolled. Abnormal hormone levels were common in children with ACC (n = 31), and in terms of clinical presentation, sexual precocity was the most common (n = 14, 35.0%), followed by Cushing’s syndrome (n = 12, 30.0%). Seven of 40 children received neoadjuvant chemotherapy due to a maximum lesion diameter greater than 10 cm (n = 4), invasion of surrounding tissues (n = 2), intravenous tumor thrombus (n = 2), and/or distant metastasis (n = 2); 2 patients achieved partial response, and 5 had stable disease according to the RECIST 1.1 standard. Furthermore, 3D tumor volume reconstruction was performed in 5 children before and after neoadjuvant chemotherapy. Tumor volumes were significantly reduced in all 5 children, with a median volume reduction of 270 (interquartile range, IQR 83, 293) (range: 49–413) ml. After surgery with/without chemotherapy, the 5-year overall survival rate for all children was 90.0% (95% CI-confidence interval 80.0–100.0%), and the 5-year event-free survival rate was 81.5% (95% CI 68.0–97.7%). Conclusion In the diagnosis and treatment of pediatric ACC, a comprehensive endocrine evaluation is necessary to facilitate early diagnosis. Surgery and chemotherapy are important components of ACC treatment, and neoadjuvant chemotherapy should be considered for children with ACC who meet certain criteria, such as a large tumor, distant metastases, or poor general condition.

Published
2023
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