445 results on '"Sherman, Jonathan H."'
Search Results
152. Limiting the Current Density During Localization of the Primary Motor Cortex by Using a Tangential-Radial Cortical Somatosensory Evoked Potentials Model, Direct Electrical Cortical Stimulation, and Electrocorticography
- Author
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Jahangiri, Faisal R, primary, Sherman, Jonathan H, additional, Sheehan, Jason, additional, Shaffrey, Mark, additional, Dumont, Aaron S, additional, Vengrow, Michael, additional, and Vega-Bermudez, Francisco, additional
- Published
- 2011
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153. Impact of temozolomide chemotherapy on seizure frequency in patients with low-grade gliomas
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Sherman, Jonathan H., primary, Moldovan, Krisztina, additional, Yeoh, H. Kwang, additional, Starke, Robert M., additional, Pouratian, Nader, additional, Shaffrey, Mark E., additional, and Schiff, David, additional
- Published
- 2011
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154. Gamma Knife surgery for parasellar meningiomas: long-term results including complications, predictive factors, and progression-free survival
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Williams, Brian J., primary, Yen, Chun Po, additional, Starke, Robert M., additional, Basina, Bhuvaneswara, additional, Nguyen, James, additional, Rainey, Jessica, additional, Sherman, Jonathan H., additional, Schlesinger, David, additional, and Sheehan, Jason P., additional
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- 2011
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155. A novel fixative for immunofluorescence staining of CD133-positive glioblastoma stem cells
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Sherman, Jonathan H., primary, Redpath, Gerard T., additional, Redick, Jan A., additional, Purow, Benjamin W., additional, Laws, Edward R., additional, Jane, John A., additional, Shaffrey, Mark E., additional, and Hussaini, Isa M., additional
- Published
- 2011
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156. Gamma Knife surgery of meningiomas located in the posterior fossa: factors predictive of outcome and remission
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Starke, Robert M., primary, Nguyen, James H., additional, Rainey, Jessica, additional, Williams, Brian J., additional, Sherman, Jonathan H., additional, Savage, Jesse, additional, Yen, Chun Po, additional, and Sheehan, Jason P., additional
- Published
- 2011
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157. Perspectives on key articles in neurosurgery
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Li, Gordon, Zada, Gabriel, Sherman, Jonathan H., Wang, Vincent Yat, Colen, Chaim B., Kim, Chae Yong, Cho, Jin Mo, Lim, Michael, and Yang, Isaac
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Neurosurgery Concepts ,Surgery ,Neurology (clinical) - Published
- 2012
158. Protecting the Genitofemoral Nerve during Direct/Extreme Lateral Interbody Fusion (DLIF/XLIF) Procedures
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Jahangiri, Faisal R., primary, Holmberg, Andrea, additional, Sherman, Jonathan H., additional, Louis, Robert, additional, Elias, Jeff, additional, and Vega-Bermudez, Francisco, additional
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- 2010
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159. Pituitary Stem Cells
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de Almeida, João Paulo C., primary, Sherman, Jonathan H., additional, Salvatori, Roberto, additional, and Quiñones-Hinojosa, Alfredo, additional
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- 2010
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160. Gamma Knife Radiosurgery for Parasellar Meningiomas: Long-term Results Including Complications, Predictive Factors and Progression Free Survival
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Williams, Brian Jeremy, primary, Yen, Chun Po, additional, Starke, Robert M., additional, Basina, Bhuvaneswara, additional, Nguyen, James, additional, Rainey, Jessica, additional, Sherman, Jonathan H., additional, Schlesinger, David, additional, and Sheehan, Jason P., additional
- Published
- 2010
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161. The posterior cervical foraminotomy in the treatment of cervical disc/osteophyte disease: a single-surgeon experience with a minimum of 5 years' clinical and radiographic follow-up
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Jagannathan, Jay, primary, Sherman, Jonathan H., additional, Szabo, Tom, additional, Shaffrey, Christopher I., additional, and Jane, John A., additional
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- 2009
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162. Case of the month: Leukemic nerve infiltration
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Aregawi, Dawit G., primary, Sherman, Jonathan H., additional, Douvas, Michael G., additional, Burns, Ted M., additional, and Schiff, David, additional
- Published
- 2009
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163. INTRAMEDULLARY SPINAL CORD METASTASIS FROM BLADDER CARCINOMA
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Crowley, R. Webster, primary, Sherman, Jonathan H., additional, Le, Brian H., additional, and Jane, John A., additional
- Published
- 2008
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164. Cintredekin besudotox in treatment of malignant glioma
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Mut, Melike, primary, Sherman, Jonathan H, additional, Shaffrey, Mark E, additional, and Schiff, David, additional
- Published
- 2008
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165. Evaluation of the role of Gamma Knife surgery in the treatment of craniopharyngiomas
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Gopalan, Rupa, primary, Dassoulas, Kasandra, additional, Rainey, Jessica, additional, Sherman, Jonathan H., additional, and Sheehan, Jason P., additional
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- 2008
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166. Radiobiology of brain metastasis: applications in stereotactic radiosurgery
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Jagannathan, Jay, primary, Sherman, Jonathan H., additional, Mehta, Gautam U., additional, and Chin, Lawrence S., additional
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- 2007
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167. Neurosurgery concepts: Key perspectives on dendritic cell vaccines, metastatic tumor treatment, and radiosurgery.
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Gordon Li, Sherman, Jonathan H., Jin Mo Cho, Lim, Michael, Khalessi, Alexander A., Colen, Chaim B., Chae Yong Kim, Vincent Yat Wang, Zada, Gabriel, Smith, Zachary A., and Isaac Yang
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NEUROSURGERY ,DENDRITIC cells ,METASTASIS ,CANCER treatment ,RADIOSURGERY ,BRAIN-derived neurotrophic factor ,ETHYLENE glycols - Abstract
Background: This is a laboratory study to investigate the effect of adding brain-derived-neurotrophic factor (BDNF) in a poly (N-isopropylacrylamide-g-poly (ethylene glycol) scaffold and its effect on spinal cord injury in a rat model. Methods: This is a laboratory investigation of a spinal cord injury in a rat model. A dorsolateral funiculotomy was used to disrupt the dorsolateral funiculus and rubrospinal tract. Animals were then injected with either the scaffold polymer or scaffold polymer with BDNF. Postoperatively, motor functions were assessed with single pellet reach to grasp task, stair case reaching task and cylinder task. Histological study was also performed to look at extent of glial scar and axonal growth. Results: Animals received BDNF containing polymer had an increased recovery rate of fine motor function of forelimb, as assessed by stair case reaching task and single pellet reach to grasp task compared with control animals that received the polymer only. There is no significant difference in the glial scar formation. BDNF treated animals also had increased axon growth including increase in the number and length of the rubrospinal tract axons. Conclusion: BDNF delivered via a scaffold polymer results in increased recovery rate in forelimb motor function in an experimental model of spinal cord injury, possibly through a promotion of growth of axons of the rubrospinal tract. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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168. Controlling plasma stimulated media in cancer treatment application.
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Dayun Yan, Sherman, Jonathan H., Xiaoqian Cheng, Ratovitski, Edward, Canady, Jerome, and Keidar, Michael
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CANCER treatment , *LOW temperature plasmas , *CANCER cells , *APOPTOSIS , *ANTINEOPLASTIC agents - Abstract
Cold atmospheric plasma (CAP) constitutes a "cocktail" of various reactive species. Accumulating evidence shows the effectiveness of CAP in killing cancer cells and decreasing the tumor size, which provides a solid basis for its potential use in cancer treatment. Currently, CAP is mainly used to directly treat cancer cells and trigger the death of cancer cells via apoptosis or necrosis. By altering the concentration of fetal bovine serum in Dulbecco's modified Eagle's medium and the temperature to store CAP stimulated media, we demonstrated controllable strategies to harness the stimulated media to kill glioblastoma cells in vitro. This study demonstrated the significant role of media in killing cancer cells via the CAP treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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169. Toxicity and efficacy of protracted low dose temozolomide for the treatment of low grade gliomas
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Pouratian, Nader, primary, Gasco, Jaime, additional, Sherman, Jonathan H., additional, Shaffrey, Mark E., additional, and Schiff, David, additional
- Published
- 2006
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170. Analysis of 445 Patients with Cushing’s Disease Treated by Transsphenoidal Surgery
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Prevedello, Daniel Monte Serrat, primary, Pouratian, Nader, additional, Sherman, Jonathan H., additional, Jane, John Anthony, additional, Lopes, M Beatriz, additional, Vance, Mary Lee, additional, and Laws, Edward R., additional
- Published
- 2006
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171. Lumbar stenosis: a personal record
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Jane, John A., primary, Sherman, Jonathan H., additional, Boulos, Paul T., additional, Luce, Craig, additional, and Dumont, Aaron S., additional
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- 2004
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172. Absence of the left inferior thyroid artery: Clinical implications
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Sherman, Jonathan H., primary and Colborn, Gene L., additional
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- 2003
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173. Neurosurgery concepts: Key perspectives on regulatory proteins, management of ossification of the posterior longitudinal ligament, and radiosurgery for intracranial lesions.
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Sherman, Jonathan H., Smith, Zachary A., Jin Mo Cho, Lim, Michael, Colen, Chaim B., Chae-Yong Kim, Wang, Vincent Yat, Zada, Gabriel, Li, Gordon, and Yang, Isaac
- Published
- 2013
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174. Perspectives on key articles in neurosurgery.
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Lim, Michael, Sherman, Jonathan H., Wang, Vincent Y., Smith, Zachary A., Jin Mo Cho, Colen, Chaim B., Chae Yong Kim, Zada, Gabriel, Li, Gordon, and Yang, Isaac
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RADIOSURGERY ,GLIOBLASTOMA multiforme ,HYPERTONIC solutions ,NEUROSURGERY - Abstract
The article presents abstracts on medical topics which include the effectiveness of repeat radiosurgery, the prognosis of patients with glioblastoma and the delivery of hypertonic saline.
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- 2012
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175. Neurosurgery concepts.
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Yang, Isaac, Jin Mo Cho, Colen, Chaim B., Li, Gordon, Lim, Michael, Sherman, Jonathan H., and Wang, Vincent Yat
- Published
- 2011
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176. Initial Experience with the eXtend System: A Relocatable Frame System for Multiple-Session Gamma Knife Radiosurgery
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Sayer, Faisal T., Sherman, Jonathan H., Yen, Chun-Po, Schlesinger, David J., Kersh, Ronald, and Sheehan, Jason P.
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RADIOSURGERY , *OPERATIVE surgery , *BLOOD-vessel abnormalities , *MAGNETIC resonance imaging , *QUALITY assurance , *TOMOGRAPHY , *SURGICAL instruments - Abstract
Objective: To present our initial experience with the Elekta eXtend System, a relocatable frame system for multiple-fraction or serial multiple-session radiosurgery Methods: The eXtend System comprises a carbon-fiber frame system known as the eXtend Frame, a vacuum cushion, and a vacuum pump/vacuum surveillance system. The eXtend Frame comprises a carbon-fiber frame, a mouthpiece with dental impression, and a configurable front-piece that accepts the mouthpiece and rigidly attaches to the carbon-fiber frame. Treatment preparation involves creating a dental impression, fitting the patient to the frame system at the Gamma Knife, acquiring a stereotactic computed tomography (CT) scan, and co-registering a volumetric magnetic resonance image. Measurements taken at the time of CT imaging using high-precision electronic probes locate the patient''s head within the eXtend frame. These measurements are compared to measurements taken at the time of treatment to ensure the patient is in proper treatment position. Vacuum surveillance interlocks pause the treatment if the patient moves within the eXtend frame. Results: As of June 2010, we have treated four patients at the University of Virginia with the eXtend System. In all cases treated to date, we were able to complete all fractions of the prescribed treatments. In addition, while in some cases repositioning before a given fraction required several attempts, we were able to achieve a radial repositioning error of less than 1 mm without taking new reference measurements and repeating patient setup and imaging. Conclusions: Gamma Knife radiosurgery (GKRS) has traditionally been a single-fraction treatment modality. The eXtend System expands the range of indications for GKRS to those that may benefit from multi-fraction or serial multi-session techniques. The relocatable eXtend frame can provide non-invasive head fixation while maintaining a high accuracy, high dose, and the steep gradients associated with GKRS. [Copyright &y& Elsevier]
- Published
- 2011
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177. MR imaging characteristics of oligodendroglial tumors with assessment of 1p/19q deletion status.
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Sherman, Jonathan H., Prevedello, Daniel M., Shah, Lubdha, Raghavan, Prashant, Pouratian, Nader, Starke, Robert M., Lopes, M. Beatriz S., Shaffrey, Mark E., and Schiff, David
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NERVOUS system tumors , *TUMORS , *DRUG therapy , *MAGNETIC resonance imaging , *GLIOMAS , *PATIENTS - Abstract
Purpose: Patients with oligodendrogliomas with allelic loss of chromosomal arm 1p and 19q have been shown, especially with anaplastic oligodendrogliomas, to have both a better initial and long-term response to chemotherapy as well as an improved overall survival. Effective treatment of patients with brain tumors requires accurate diagnostic techniques. MR imaging can be used to help differentiate between low- and high-grade tumors. We hypothesize that certain MR imaging characteristics can be used to differentiate between patients with and without 1p and 19q deletion. Methods: Using the clinical database at the University of Virginia Neuro-Oncology Center, we identified adult patients with grade II and III oligodendroglial tumors who underwent treatment from 2002 to 2007. Age at diagnosis, gender, tumor grade, chromosomal deletion status, duration of follow-up, and MR imaging characteristics were analyzed; the latter was read by a blinded neuroradiologist. Results: One hundred and four patients met the inclusion criteria. Of these patients, 44 manifested 1p/19q co-deletion and 60 patients lacked this deletion. The greatest cross-sectional area (mean) of the tumor measured 23.4 cm for patients with the co-deletion and 31.7 cm for patients with intact alleles ( p = 0.008). In addition, inner table thinning was noted directly adjacent to seven tumors with intact 1p and 19q alleles and in no tumors with the 1p/19q co-deletion ( p = 0.020). Amongst patients with pure oligodendrogliomas, those with 1p/19q co-deletion had tumors more often confined to a single lobe as compared with those patients without the co-deletion ( p = 0.023). Finally, tumors with intact alleles were more often found in the temporal lobe (45.0%) as compared with co-deleted tumors (22.7%) ( p = 0.011). Conclusion: MR imaging is a valuable imaging modality for differentiating between oligodendrogliomas with or without the 1p/19q deletion. While imaging will never replace definitive tissue diagnosis, imaging characteristics such as tumor size, location, and overlying skull thinning can assist clinicians in assessing patients with oligodendroglial tumors prior to surgical or medical intervention. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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178. Reconstruction of the sellar dura in transsphenoidal surgery using an expanded polytetrafluoroethylene dural substitute
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Sherman, Jonathan H., Pouratian, Nader, Okonkwo, David O., Jane, John A., and Laws, Edward R.
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FOLLICLE-stimulating hormone , *CEREBROSPINAL fluid , *CREUTZFELDT-Jakob disease ,TUMOR surgery - Abstract
Abstract: Background: The transsphenoidal approach for resecting pituitary tumors has classically included reconstruction of the anterior wall of the sella turcica. A variety of materials have been used in this process for the purpose of both recreating the original anatomy and preventing postoperative cerebrospinal fluid (CSF) leaks. We studied the use of an ePTFE dural substitute (GORE Preclude® MVP®, W.L. Gore & Associates, Flagstaff, Arizona, USA), as a method for obtaining reliable reconstruction of the sellar dura. Methods: A prospective alternate case trial was designed to assess this new dural substitute wherein 60 patients who underwent transsphenoidal surgical resection of intrasellar lesions larger than 1 cm were included. Thirty patients had the sellar dura closed with ePTFE dural substitute, whereas 30 patients underwent anterior wall reconstruction as ordinarily performed in our institution. Results: Each patient was reassessed at closure, and the operative site and sphenoid sinus were evaluated with 3-months-postoperative magnetic resonance imaging. Three patients experienced postoperative CSF leaks: 1 with ePTFE dural substitute and 2 without. All 3 patients underwent a second operation to repair the CSF leak, without further complications. No other postoperative complications were noted in the series. Conclusion: Expanded polytetrafluoroethylene dural substitute provides a safe and effective adjunctive method for reconstruction of the sellar dura. [Copyright &y& Elsevier]
- Published
- 2008
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179. Supratentorial dural-based hemangioblastoma not associated with von Hippel Lindau complex.
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Sherman, Jonathan H., Le, B. H., Okonkwo, D. O., and Jane, J. A.
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HEMANGIOMAS , *TUMORS , *RADIOGRAPHY , *NERVOUS system ,CENTRAL nervous system tumors - Abstract
Hemangioblastomas are rarely found in a supratentorial location and are commonly associated with the von Hippel-Lindau complex. Therefore, patients with such tumors must be evaluated for both other hemangioblastomas within the central nervous system as well as for this complex via physical examination, radiographic examination, and genetic testing. We report the seventh case of a patient with an isolated supratentorial dural based hemangioblastoma not associated with the von Hippel-Lindau complex. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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180. In Vitro and In Vivo Enhancement of Temozolomide Effect in Human Glioblastoma by Non-Invasive Application of Cold Atmospheric Plasma.
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Soni, Vikas, Adhikari, Manish, Simonyan, Hayk, Lin, Li, Sherman, Jonathan H., Young, Colin N., and Keidar, Michael
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IN vitro studies ,DRUG approval ,SURVIVAL ,COMBINATION drug therapy ,IN vivo studies ,ANIMAL experimentation ,CANCER chemotherapy ,GLIOMAS ,ATMOSPHERIC pressure ,ANTINEOPLASTIC agents ,CANCER relapse ,TEMOZOLOMIDE ,PLASMA gases ,GENES ,CELL lines ,MICE ,PHARMACODYNAMICS - Abstract
Simple Summary: Glioblastoma (GBM) is an aggressive type of brain cancer, with which only 25% of patients survive for more than one year. Treatment of GBM has remained a challenge due to its resistance to chemotherapy. Here, we aimed to assess the potential for a combination therapy of cold atmospheric plasma (CAP) and Temozolomide (TMZ) to treat GBM. We confirmed the effect of co-treatment on different GBM cell lines in vitro and determined the enhancement of the effect of TMZ and the potential sensitization of GBM to CAP + TMZ in murine models in vivo. We found that co-treatment with CAP + TMZ inhibited GBM significantly compared to single treatment with CAP or TMZ alone. We provided further evidence related to the bone penetration of reactive oxygen and nitrogen species, as well as electromagnetic waves generated by CAP. RNA sequencing further indicated an effect of CAP + TMZ on cell cycle pathways. Collectively, these findings point to potential non-invasive translational approaches to target GBM in the future. Glioblastoma (GBM) is one of the most aggressive forms of adult brain cancers and is highly resistant to treatment, with a median survival of 12–18 months after diagnosis. The poor survival is due to its infiltrative pattern of invasion into the normal brain parenchyma, the diffuse nature of its growth, and its ability to quickly grow, spread, and relapse. Temozolomide is a well-known FDA-approved alkylating chemotherapy agent used for the treatment of high-grade malignant gliomas, and it has been shown to improve overall survival. However, in most cases, the tumor relapses. In recent years, CAP has been used as an emerging technology for cancer therapy. The purpose of this study was to implement a combination therapy of CAP and TMZ to enhance the effect of TMZ and apparently sensitize GBMs. In vitro evaluations in TMZ-sensitive and resistant GBM cell lines established a CAP chemotherapy enhancement and potential sensitization effect across various ranges of CAP jet application. This was further supported with in vivo findings demonstrating that a single CAP jet applied non-invasively through the skull potentially sensitizes GBM to subsequent treatment with TMZ. Gene functional enrichment analysis further demonstrated that co-treatment with CAP and TMZ resulted in a downregulation of cell cycle pathway genes. These observations indicate that CAP can be potentially useful in sensitizing GBM to chemotherapy and for the treatment of glioblastoma as a non-invasive translational therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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181. Multi-Modal Biological Destruction by Cold Atmospheric Plasma: Capability and Mechanism.
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Yan, Dayun, Malyavko, Alisa, Wang, Qihui, Ostrikov, Kostya, Sherman, Jonathan H., and Keidar, Michael
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LOW temperature plasmas ,VIRUS inactivation ,BACTERIAL cells ,IONIZED gases ,CELL death - Abstract
Cold atmospheric plasma (CAP) is a near-room-temperature, partially ionized gas composed of reactive neutral and charged species. CAP also generates physical factors, including ultraviolet (UV) radiation and thermal and electromagnetic (EM) effects. Studies over the past decade demonstrated that CAP could effectively induce death in a wide range of cell types, from mammalian to bacterial cells. Viruses can also be inactivated by a CAP treatment. The CAP-triggered cell-death types mainly include apoptosis, necrosis, and autophagy-associated cell death. Cell death and virus inactivation triggered by CAP are the foundation of the emerging medical applications of CAP, including cancer therapy, sterilization, and wound healing. Here, we systematically analyze the entire picture of multi-modal biological destruction by CAP treatment and their underlying mechanisms based on the latest discoveries particularly the physical effects on cancer cells. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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182. Nanoparticles as a Tool in Neuro-Oncology Theranostics.
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Klein, Andrea L., Nugent, Grant, Cavendish, John, Geldenhuys, Werner J., Sriram, Krishnan, Porter, Dale, Fladeland, Ross, Lockman, Paul R., and Sherman, Jonathan H.
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POSITRON emission tomography ,ACOUSTIC imaging ,COMPANION diagnostics ,NANOPARTICLES ,CARDIAC radionuclide imaging ,METAL nanoparticles - Abstract
The rapid growth of nanotechnology and the development of novel nanomaterials with unique physicochemical characteristics provides potential for the utility of nanomaterials in theranostics, including neuroimaging, for identifying neurodegenerative changes or central nervous system malignancy. Here we present a systematic and thorough review of the current evidence pertaining to the imaging characteristics of various nanomaterials, their associated toxicity profiles, and mechanisms for enhancing tropism in an effort to demonstrate the utility of nanoparticles as an imaging tool in neuro-oncology. Particular attention is given to carbon-based and metal oxide nanoparticles and their theranostic utility in MRI, CT, photoacoustic imaging, PET imaging, fluorescent and NIR fluorescent imaging, and SPECT imaging. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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183. Combination therapy of cold atmospheric plasma (CAP) with temozolomide in the treatment of U87MG glioblastoma cells.
- Author
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Gjika, Eda, Pal-Ghosh, Sonali, Kirschner, Megan E., Lin, Li, Sherman, Jonathan H., Stepp, Mary Ann, and Keidar, Michael
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TEMOZOLOMIDE ,CANCER treatment ,CANCER chemotherapy ,IONIZED gases ,GLIOBLASTOMA multiforme - Abstract
Cold atmospheric plasma (CAP) technology, a relatively novel technique mainly investigated as a stand-alone cancer treatment method in vivo and in vitro, is being proposed for application in conjunction with chemotherapy. In this study, we explore whether CAP, an ionized gas produced in laboratory settings and that operates at near room temperature, can enhance Temozolomide (TMZ) cytotoxicity on a glioblastoma cell line (U87MG). Temozolomide is the first line of treatment for glioblastoma, one of the most aggressive brain tumors that remains incurable despite advancements with treatment modalities. The cellular response to a single CAP treatment followed by three treatments with TMZ was monitored with a cell viability assay. According to the cell viability results, CAP treatment successfully augmented the effect of a cytotoxic TMZ dose (50 μM) and further restored the effect of a non-cytotoxic TMZ dose (10 μM). Application of CAP in conjunction TMZ increased DNA damage measured by the phosphorylation of H2AX and induced G2/M cell cycle arrest. These findings were supported by additional data indicating reduced cell migration and increased αvβ3 and αvβ5 cell surface integrin expression as a result of combined CAP–TMZ treatment. The data presented in this study serve as evidence that CAP technology can be a suitable candidate for combination therapy with existing chemotherapeutic drugs. CAP can also be investigated in future studies for sensitizing glioblastoma cells to TMZ and other drugs available in the market. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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184. The Cell Activation Phenomena in the Cold Atmospheric Plasma Cancer Treatment.
- Author
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Yan, Dayun, Xu, Wenjun, Yao, Xiaoliang, Lin, Li, Sherman, Jonathan H., and Keidar, Michael
- Abstract
Cold Atmospheric Plasma (CAP) is an ionized gas with a near room temperature. CAP is a controllable source for reactive species, neutral particles, electromagnetic field and UV radiation. CAP showed the promising application in cancer treatment through the demonstration in vitro and in vivo. In this study, we first demonstrate the existence of an activation state on the CAP-treated cancer cells, which drastically decreases the threshold of cell vulnerability to the cytotoxicity of the CAP-originated reactive species such as H
2 O2 and NO2 − . The cytotoxicity of CAP treatment is still dependent on the CAP-originated reactive species. The activation state of cancer cells will not cause noticeable cytotoxicity. This activation is an instantaneous process, started even just 2 s after the CAP treatment begins. The noticeable activation on the cancer cells starts 10-20 s during the CAP treatment. In contrast, the de-sensitization of activation takes 5 hours after the CAP treatment. The CAP-based cell activation explains the mechanism by which direct CAP treatment causes a much stronger cytotoxicity over the cancer cells compared with an indirect CAP treatment do, which is a key to understand what the effect of CAP on cancer cells. [ABSTRACT FROM AUTHOR]- Published
- 2018
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185. Impact of Cochlear Dose on Hearing Preservation Following Stereotactic Radiosurgery in Treatment of Vestibular Schwannomas: A Multi-Center Study.
- Author
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Chang, Steven D., Muacevic, Alexander, Klein, Andrea L., Sherman, Jonathan H., Romanelli, Pantaleo, Santa Maria, Peter L., Fuerweger, Christoph, Bossi Zanetti, Isa, Beltramo, Giancarlo, Vaisbush, Yona, Tran, Emma, Feng, Austin, Teng, Hao, Meola, Antonio, Gibbs, Iris, Tolisano, Antony M., Kutz, Joe Walter, Wardak, Zabi, Nedzi, Lucien A., and Hong, Robert
- Subjects
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STEREOTACTIC radiosurgery , *HEARING levels , *RADIATION doses , *WORD recognition , *HEARING disorders , *SCHWANNOMAS , *ACOUSTIC neuroma , *THERAPEUTICS - Abstract
Stereotactic radiosurgery (SRS) is a well-established treatment for vestibular schwannomas (VS). Hearing loss remains a main morbidity of VS and its treatments, including SRS. The effects of radiation parameters of SRS on hearing remain unknown. The goal of this study is to determine the effect of tumor volume, patient demographics, pretreatment hearing status, cochlear radiation dose, total tumor radiation dose, fractionation, and other radiotherapy parameters on hearing deterioration. Multicenter retrospective analysis of 611 patients who underwent SRS for VS from 1990–2020 and had pre- and post-treatment audiograms. Pure tone averages (PTAs) increased and word recognition scores (WRSs) decreased in treated ears at 12–60 months while remaining stable in untreated ears. Higher baseline PTA, higher tumor radiation dose, higher maximum cochlear dose, and usage of single fraction resulted in higher post radiation PTA; WRS was only predicted by baseline WRS and age. Higher baseline PTA, single fraction treatment, higher tumor radiation dose, and higher maximum cochlear dose resulted in a faster deterioration in PTA. Below a maximum cochlear dose of 3 Gy, there were no statistically significant changes in PTA or WRS. Decline of hearing at one year in VS patients after SRS is directly related to maximum cochlear dose, single versus 3-fraction treatment, total tumor radiation dose, and baseline hearing level. The maximum safe cochlear dose for hearingtbrowd preservation at one year is 3 Gy, and the use of 3 fractions instead of one fraction was better at preserving hearing. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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186. Functional connectivity reveals different brain networks underlying the idiopathic foreign accent syndrome.
- Author
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Dadario, Nicholas B., Piper, Keaton, Young, Isabella M, Sherman, Jonathan H., and Sughrue, Michael E.
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LARGE-scale brain networks , *FUNCTIONAL connectivity , *STRESS (Linguistics) , *DIFFUSION tensor imaging , *BRAIN damage - Abstract
Foreign accent syndrome (FAS) is characterized by new onset speech that is perceived as foreign. Available data from acquired cases suggests focal brain damage in language and sensorimotor brain networks, but little remains known about abnormal functional connectivity in idiopathic cases of FAS without structural damage. Here, connectomic analyses were completed on three patients with idiopathic FAS to investigate unique functional connectivity abnormalities underlying accent change for the first time. Machine learning (ML)-based algorithms generated personalized brain connectomes based on a validated parcellation scheme from the Human Connectome Project (HCP). Diffusion tractography was performed on each patient to rule out structural fiber damage to the language system. Resting-state-fMRI was assessed with ML-based software to examine functional connectivity between individual parcellations within language and sensorimotor networks and subcortical structures. Functional connectivity matrices were created and compared against a dataset of 200 healthy subjects to identify abnormally connected parcellations. Three female patients (28–42 years) who presented with accent changes from Australian English to Irish (n = 2) or American English to British English (n = 1) demonstrated fully intact language system structural connectivity. All patients demonstrated functional connectivity anomalies within language and sensorimotor networks in numerous left frontal regions and between subcortical structures in one patient. Few commonalities in functional connectivity anomalies were identified between all three patients, specifically 3 internal-network parcellation pairs. No common inter-network functional connectivity anomalies were identified between all patients. The current study demonstrates specific language, and sensorimotor functional connectivity abnormalities can exist and be quantitatively shown in the absence of structural damage for future study. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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- View/download PDF
187. Theranostic Potential of Adaptive Cold Atmospheric Plasma with Temozolomide to Checkmate Glioblastoma: An In Vitro Study.
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Soni, Vikas, Adhikari, Manish, Lin, Li, Sherman, Jonathan H., and Keidar, Michael
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IN vitro studies , *BLOOD plasma , *GLIOMAS , *TEMOZOLOMIDE , *COMBINED modality therapy , *MOLECULAR structure , *REACTIVE oxygen species , *CELL death - Abstract
Simple Summary: Glioblastoma (GBM) is an aggressive form of brain cancer. Here, we present a combination therapy of cold atmospheric plasma (CAP) and temozolomide (TMZ) to treat GBM in vitro. We analyze the effects of the co-treatment in two GBM (TMZ-resistant and -sensitive) cell lines. The aim of this study is mainly to sensitize these cells using CAP so that they respond well to TMZ. We further found that the removal of cell culture media after CAP treatment does not affect the sensitivity of CAP to cancer cells but enhances the effects of TMZ. However, it was observed in our study that keeping the CAP-treated media for a shorter time did not significantly inhibit T98G cells. Interestingly, keeping the same plasma-treated media for a longer duration resulted in a decrease in cell viability. On the contrary, TMZ-sensitive cell A172 responded well to the co-treatment. This could be a potential reason for the sensitization of the combination therapy. Cold atmospheric plasma (CAP) has been used for the treatment of various cancers. The anti-cancer properties of CAP are mainly due to the reactive species generated from it. Here, we analyze the efficacy of CAP in combination with temozolomide (TMZ) in two different human glioblastoma cell lines, T98G and A172, in vitro using various conditions. We also establish an optimized dose of the co-treatment to study potential sensitization in TMZ-resistant cells. The removal of cell culture media after CAP treatment did not affect the sensitivity of CAP to cancer cells. However, keeping the CAP-treated media for a shorter time helped in the slight proliferation of T98G cells, while keeping the same media for longer durations resulted in a decrease in its survivability. This could be a potential reason for the sensitization of the cells in combination treatment. Co-treatment effectively increased the lactate dehydrogenase (LDH) activity, indicating cytotoxicity. Furthermore, apoptosis and caspase-3 activity also significantly increased in both cell lines, implying the anticancer nature of the combination. The microscopic analysis of the cells post-treatment indicated nuclear fragmentation, and caspase activity demonstrated apoptosis. Therefore, a combination treatment of CAP and TMZ may be a potent therapeutic modality to treat glioblastoma. This could also indicate that a pre-treatment with CAP causes the cells to be more sensitive to chemotherapy treatment. [ABSTRACT FROM AUTHOR]
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- 2022
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188. In Reply to the "Letter to the Editor Regarding: Virtual Reality During Brain Mapping for Awake-Patient Brain Tumor Surgery: Proposed Tasks and Domains to Test".
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Katsevman, Gennadiy A., Greenleaf, Walter, García-García, Ricardo, Perea, Maria Victoria, Ladera, Valentina, Sherman, Jonathan H., and Rodríguez, Gabriel
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BRAIN mapping , *BRAIN tumors , *VIRTUAL reality , *VIRTUAL reality therapy , *BRAIN surgery ,TUMOR surgery - Published
- 2024
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189. Racial Disparities Affecting Postoperative Outcomes After Brain Tumor Resection.
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Thomas, George, Almeida, Neil D., Mast, Grayson, Quigley, Ryan, Almeida, Nyle C., Amdur, Richard L., Moss, Ankita, Mahfuz, Ali, and Sherman, Jonathan H.
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RACIAL inequality , *BRAIN tumors , *URINARY tract infections , *ASIANS , *CRANIOTOMY ,TUMOR surgery - Abstract
To investigate racial disparities in 30-day postoperative outcomes of craniotomy for glioma resection. 2006–2019 American College of Surgeons' National Surgical Quality Improvement Program files were queried for all patients who underwent a craniotomy for a supratentorial glioma resection. Racial disparities in preoperative variables were studied between the demographic cohorts of Asian, African Americans, Hispanics, and Caucasian. Fisher exact tests were used to examine association of preoperative variables with race. Multivariable logistic regression models, adjusted for all preoperative variables associated with race, were used to determine the odds ratios of postoperative outcomes for each demographic cohort in comparison with Caucasian patients. A total of 12,544 patients were identified: 4% Asian, 5% African American, 7% Hispanic, and 85% Caucasian. African American patients had significantly higher adjusted odds than Caucasian patients of major adverse cardiovascular events (adjusted odds ratio [aOR]: 1.827, 95% confidence interval [CI]: 1.155–2.891, P = 0.01), pulmonary events (aOR: 1.683, 95% CI: 1.145–2.473, P = 0.008), and urinary tract infection (aOR: 2.016, 95% CI: 1.221–3.327, P = 0.006). Asian patients had significantly higher odds than Caucasian patients of requiring a transfusion (aOR: 2.094, 95% CI: 1.343–3.266, P = 0.001). All demographic cohorts had higher odds of having an extended length of stay than Caucasian patients. African American patients who undergo a craniotomy for glioma resection have almost twice the odds of Caucasian patients of having a postoperative major cardiovascular complication, pulmonary complication, or urinary tract infection. All minority groups have higher odds of an extended length of stay as compared with Caucasian patients. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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190. Virtual Reality During Brain Mapping for Awake-Patient Brain Tumor Surgery: Proposed Tasks and Domains to Test.
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Katsevman, Gennadiy A., Greenleaf, Walter, García-García, Ricardo, Perea, Maria Victoria, Ladera, Valentina, Sherman, Jonathan H., and Rodríguez, Gabriel
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BRAIN mapping , *BRAIN tumors , *VIRTUAL reality , *BRAIN surgery , *OPERATIVE surgery ,TUMOR surgery - Abstract
Virtual reality (VR) use in health care has increased over the past few decades, with its utility expanding from a teaching tool to a highly reliable neuro-technology adjunct in multiple fields including neurosurgery. Generally, brain tumor surgery with the patient awake has only been performed for mapping of language and motor areas. With the rise of VR and advancing surgical techniques, neurosurgical teams are developing an increased understanding of patients' anatomo-functional connectivity. Consequently, more specific cognitive tasks are being required for the mapping and preservation of deeper layers of cognition. An extensive literature review was conducted with the inclusion criteria of manuscripts that described the use of VR during awake neurosurgery mapping. We identified 3 recent articles that met our inclusion criteria, yet none of them addressed the specific use of VR for cognition mapping. Consequently, a cognitive task phase was performed to search and craft the tasks and domains that better filled the spotted niche of this need inside the operating room. A proposed protocol was developed with 5 potential uses of VR for brain mapping during awake neurosurgery, each of them with a specific proposed example of use. The authors advocate for the use of a VR protocol as a feasible functional tool in awake-patient brain tumor surgery by using it as a complement during cognitive screening in addition to language testing. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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191. Coagulation Profile as a Significant Risk Factor for Short-Term Complications and Mortality after Anterior Cervical Discectomy and Fusion.
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Almeida, Neil D., Lee, Ryan, Wei, Chapman, Lee, Danny, Asif, Usman, Almeida, Nyle C., Klein, Andrea L., Hogan, Elizabeth, Sack, Kenneth, and Sherman, Jonathan H.
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DISCECTOMY , *PREOPERATIVE risk factors , *BLOOD coagulation , *BLOOD coagulation disorders , *INTERNATIONAL normalized ratio , *LENGTH of stay in hospitals , *CERVICAL spondylotic myelopathy , *BLOOD platelet disorders - Abstract
Cervical degenerative disc disease is the most common indication for anterior cervical discectomy and fusion. Given the possible complications, patients are stratified before anterior cervical discectomy and fusion by preoperative risk factors to optimize treatment. One preoperative factor is a patient's coagulation profile. The American College of Surgeons–National Surgical Quality Improvement Database was used to identify patient preoperative coagulation profile and postoperative complications. By generating binary logistic regression models, each of the 4 abnormal coagulation categories (bleeding disorder, low platelet count, high partial thromboplastin time, and high international normalized ratio [INR]) were analyzed for their independent impact on increased risk for complications compared with the control cohort. A total of 61,977 patients were assessed. The most common abnormal coagulation was abnormal platelet count (n = 2149). The most common postoperative outcome was an extended length of hospital stay among patients with an abnormal coagulation profile relative to the control cohort. After multivariate analysis, patients with an abnormal INR (odds ratio, 2.2 [1.3–3.8]; P = 0.003) or abnormal platelet count (odds ratio, 1.5 [1.2–2.1]; P = 0.003) had a higher chance of having an extended length of hospital stay relative to patients having a normal coagulation profile. Having an abnormal INR was found to be associated with an increased risk for having "Any complication." Our results show significant differences in the incidence rates of a multitude of complications among the 5 groups based on univariate analysis. Patients with any abnormal coagulation disorder had increased rates of developing any complication or having an extended length of hospital stay. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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192. The anti-glioblastoma effect of cold atmospheric plasma treatment: physical pathway v.s. chemical pathway.
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Yan, Dayun, Wang, Qihui, Malyavko, Alisa, Zolotukhin, Denis B., Adhikari, Manish, Sherman, Jonathan H., and Keidar, Michael
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GLIOBLASTOMA multiforme , *IONIZED gases , *CANCER treatment , *NECROSIS , *ULTRAVIOLET radiation - Abstract
Cold atmospheric plasma (CAP), a near room temperature ionized gas, has shown potential application in many branches of medicine, particularly in cancer treatment. In previous studies, the biological effect of CAP on cancer cells and other mammalian cells has been based solely on the chemical factors in CAP, particularly the reactive species. Therefore, plasma medicine has been regarded as a reactive species-based medicine, and the physical factors in CAP such as the thermal effect, ultraviolet irradiation, and electromagnetic effect have been regarded as ignorable factors. In this study, we investigated the effect of a physical CAP treatment on glioblastoma cells. For the first time, we demonstrated that the physical factors in CAP could reinstate the positive selectivity on CAP-treated astrocytes. The positive selectivity was a result of necrosis, a new cell death in glioblastoma cells characterized by the leak of bulk water from the cell membrane. The physically-based CAP treatment overcomed a large limitation of the traditional chemically based CAP treatment, which had complete dependence on the sensitivity of cells to reactive species. The physically-based CAP treatment is a potential non-invasive anti-tumor tool, which may have wide application for tumors located in deeper tissues. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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193. Perioperative Complications Associated with Severity of Anemia in Geriatric Patients Undergoing Spinal Procedures.
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Almeida, Neil D., Lee, Ryan, Bestourous, Daniel, Klein, Andrea L., Parekh, Neil R., Sack, Kenneth, and Sherman, Jonathan H.
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SURGICAL complications , *GERIATRIC surgery , *HEMATOCRIT , *SURGICAL site infections , *URINARY tract infections , *ANEMIA , *ACUTE kidney failure - Abstract
To investigate preoperative baseline anemia, stratified by severity as a function of hematocrit level, as a risk factor for perioperative complications in geriatric patients undergoing spinal procedures. Previous literature has examined the impact of anemia on risk for complications and adverse outcomes in patients undergoing elective spinal procedures. However, there is a paucity of literature analyzing the impact of anemia in the geriatric population, specifically. The American College of Surgeons–National Surgical Quality Improvement Database was used to identify patients older than 65 years who had undergone elective spinal procedures and were subsequently stratified into 3 separate cohorts based on hematocrit levels: severe/moderate (hematocrit level <30%), mild (30%–37%), and no anemia (>38%). These patient samples were then analyzed using multivariate analyses to assess severity of anemia as a risk factor for complications in elderly patients undergoing spinal procedures. When anemia classes were analyzed as separate independent risk factors for complications, mild anemia (class II) was a significant risk factor for the same complications as moderate/severe anemia (class III/IV), with the exception of 2 complications, compared with nonanemic patients. Mild anemia was independently associated with wound dehiscence (odds ratio, 1.521; 95% confidence interval, 1.126–2.054; P = 0.006), whereas moderate/severe anemia did not show an increased risk for wound dehiscence. However, moderate/severe anemia independently increased the risk for deep venous thromboembolism (odds ratio, 1.437; 95% confidence interval, 1.028–2.011; P = 0.034), compared with mild anemia. Both categories of anemia independently increased the risk for additional complications such as deep incisional surgical site infection, organ/space surgical site infection, pneumonia, unplanned intubation, ventilator dependence, progressive renal insufficiency, acute renal failure, urinary tract infections, cardiac arrest, myocardial infarctions, blood transfusions, systemic sepsis, reoperation, extended length of stay of ≥5 days, unplanned readmission, and mortality. This study indicated that patients with preoperative baseline anemia were at risk for requiring transfusions, renal failure, and infectious complications. Physicians should be cognizant of anemia as a risk factor affecting numerous perioperative complications and adverse outcomes to work toward improving health-related quality of life. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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194. Cold Atmospheric Plasma as an Adjunct to Immunotherapy for Glioblastoma Multiforme.
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Almeida, Neil D., Klein, Andrea L., Hogan, Elizabeth A., Terhaar, Samantha J., Kedda, Jayanidhi, Uppal, Prayerna, Sack, Kenneth, Keidar, Michael, and Sherman, Jonathan H.
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GLIOBLASTOMA multiforme , *LOW temperature plasmas , *BRAIN tumors , *IMMUNOTHERAPY , *PHASES of matter - Abstract
Glioblastoma multiforme (GBM) is the most common and aggressive form of brain cancer in adults. GBM carries a dismal prognosis because of its proliferative, invasive, and angiogenic capabilities and because of its ability to downregulate the immune system. Immune-based therapies under investigation for GBM have been unsuccessful in vivo because of this downregulation. Cold atmospheric plasma (CAP) is a high-energy state of matter that can be applied directly or indirectly to tumor tissue to serve as an adjunct to immunotherapy in the treatment of GBM because it upregulates the immune system by the induction of reactive oxygen species. CAP has the potential to improve the efficacy of existing and investigative immunotherapies for GBM. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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195. Plasmas for Treating Cancer: Opportunities for Adaptive and Self-Adaptive Approaches.
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Keidar, Michael, Yan, Dayun, Beilis, Isak I., Trink, Barry, and Sherman, Jonathan H.
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CANCER treatment , *LOW temperature plasmas , *PLASMA gases , *HOMOGENEOUS plasma , *HIGH temperatures - Abstract
Plasma is an ionized gas that is typically formed under high-temperature laboratory conditions. Recent progress in atmospheric plasmas has led to cold atmospheric plasma (CAP) devices with ion temperatures close to room temperature. The unique chemical and physical properties of CAP have led to its use in various biomedical applications including cancer therapy. CAP exhibits a spontaneous transition from a spatially homogeneous state to a modifiable pattern that is subject to self-organization. In this Opinion article, we discuss some new applications for plasma in cancer therapy based on plasma self-organization, which enables adaptive features in plasma-based therapeutic systems. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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196. Use of MRI in diabetic lumbosacral radiculoplexus neuropathy: case report and review of the literature.
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Mccormack, Erin P., Alam, Meher, Erickson, Nicholas J., Cherrick, Abraham A., Powell, Emily, and Sherman, Jonathan H.
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MAGNETIC resonance imaging , *DIABETIC neuropathies , *LUMBOSACRAL plexus , *PERIPHERAL nerve injuries , *RADICULOPATHY - Abstract
Diabetic lumbosacral radiculoplexus neuropathy is often confused with radiculopathy in the context of spinal degenerative disc disease including spinal stenosis. Accuracy in diagnosis may prevent unnecessary interventional procedures including selective nerve root blocks or epidural steroid injections or even surgery in selected cases. Our patient with known diabetes and lumbar disc disease presented with acute onset of pain in L5-S1 distribution of the left lower extremity. Initial MR imaging of the lumbar spine did not show sufficient structural changes to explain her symptomatology. An MR neurogram of the lumbosacral plexus revealed inflammation within the bilateral sciatic and femoral nerves; subsequent EMG demonstrated a generalized sensorimotor neuropathy but no evidence of plexopathy. To our knowledge, this is the first case report that utilized MR imaging of the pelvis to assist in the diagnosis of diabetic lumbosacral radiculoplexus neuropathy (DLRPN). [ABSTRACT FROM AUTHOR]
- Published
- 2018
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197. Long-term clinical outcomes in a cohort of patients with solitary plasmacytoma treated in the modern era
- Author
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F. A. Sharpley, P Neffa, F. Panitsas, J. Kothari, M. Subesinghe, D. Cutter, R. Shcolnik Szor, G. Aparedcida Martinez, V. Rocha, K. Ramasamy, and Sherman, Jonathan H.
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Clinical Oncology ,Imaging Techniques ,Science ,Immune Cells ,Plasma Cells ,Immunology ,Cancer Treatment ,Radiation Therapy ,Surgical and Invasive Medical Procedures ,Research and Analysis Methods ,Plasma Cell Disorders ,Diagnostic Radiology ,Hematologic Cancers and Related Disorders ,03 medical and health sciences ,White Blood Cells ,0302 clinical medicine ,Diagnostic Medicine ,Animal Cells ,Medicine and Health Sciences ,Myelomas and Lymphoproliferative Diseases ,Multidisciplinary ,Blood Cells ,Surgical Resection ,Radiology and Imaging ,Cancers and Neoplasms ,Biology and Life Sciences ,Hematology ,Cell Biology ,Magnetic Resonance Imaging ,Myelomas ,Oncology ,030220 oncology & carcinogenesis ,Medicine ,Cellular Types ,Clinical Medicine ,Multiple Myeloma ,030215 immunology ,Research Article - Abstract
BackgroundThe risk of recurrence of solitary plasmacytoma (SP)/progression to MM is well established, but patient, imaging and treatment factors influencing risk of progression require further evaluation.MethodsThis is a retrospective analysis of 66 SP patients (23 UK, 43 Brazil) diagnosed 1989–2016. Patient baseline characteristics were recorded. The incidence of progression to MM was calculated, including biochemical and imaging findings and the treatment modality received. Survival estimates were determined by Kaplan-Meier analyses.ResultsWith a median follow-up of 53.6 months the 5 year overall survival (OS) was 90.7% (95%CI 79–96%). The median progression free survival (PFS) from diagnosis was 61 months. Cumulative incidence of progression to MM was 49.9% at 5 years (95% CI 35.6–62.6%) and was significantly higher with bone plasmacytoma (47.2%, 95%CI 31.9–61.1%), than an extramedullary location (8.3%, 95%CI 0.4–32.3%, Gray test p = 0.0095)). The majority of patients with solitary bony plasmacytoma (SBP) received radiotherapy (RT) (51/53, 96.2%) whereas most extramedullary cases were treated with surgical resection (7/13, 53.8%). A small proportion of SBP patients received additional upfront chemotherapy, with 5/6 in remission after a median follow-up (FU) of 10 years. The diagnostic yield of surveillance functional FU imaging without other indications of relapse/progression was low. The positive predictive value of functional FU imaging was high but with a low negative predictive value, especially in cases of suspected relapse/progression.ConclusionOur data suggests functional imaging should be used if clinical suspicion of relapse/progression, rather than a routine surveillance tool, and upfront adjuvant chemotherapy is worthy of prospective evaluation.
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- 2019
198. Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database
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Faltermeier, Claire, Chai, Timothy, Syed, Sharjeel, Lau, Nathan, Elkaim, Lior, Ibrahim, George, Wang, Anthony, Weil, Alexander, Bendel, Anne, Fallah, Aria, Tu, Albert, and Sherman, Jonathan H
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Male ,Time Factors ,Brain Neoplasms ,General Science & Technology ,Neurosciences ,Infant ,Prognosis ,Newborn ,Survival Analysis ,United States ,Brain Disorders ,Cohort Studies ,Brain Cancer ,Rare Diseases ,Infant Mortality ,Humans ,Female ,Child ,Preschool ,SEER Program ,Cancer - Abstract
INTRODUCTION:Brain tumors are the most common solid malignancy and leading cause of cancer-related deaths in infants. Current epidemiological data is limited by low numbers of reported cases. This study used a population-based approach with analysis of contemporary and historical survival curves to provide up-to-date prognostication. METHODS:Observational cohort analysis was performed using the Surveillance, Epidemiology and End Results (SEER) database. Infants with brain tumors diagnosed from 1973 to 2013 were categorized by the most common tumor types (diffuse astrocytic and oligodendroglioma, choroid plexus, embryonal, ependymal, medulloblastoma and pilocytic astrocytoma). The 1, 5 and 10 year survival was stratified by decade, with trends in management and outcomes analyzed. RESULTS:We identified 2996 affected infants satisfying inclusion criteria. All tumor types, except embryonal and choroid plexus, demonstrated improving survival with time. Infants with embryonal tumors showed a decline in survival from the 1970s to 1990s (p = 0.009), whereas infants with choroid plexus tumors had no change in survival. Infants with ependymal tumors experienced the greatest improvement in survival from 1980s to 1990s and 1990s to 2000s (p = 0.0001, p = 0.01), with 5-year survival probability improving from 28% (95% CI 15-42%) in the 1980s to 77% (95% CI 69-83%) the 2000s. The use of radiation declined from 1970 to 2000 for all tumors; however, radiation treatment for embryonal and ependymal subtypes increased after 2000. CONCLUSIONS:While overall survival for infants with brain tumors has improved from the 1970s onwards, not every tumor type has seen a statistically significant change. Given changes in management and survival, prognostication of infants with brain tumor should be updated.
- Published
- 2019
199. Excellent accuracy of ABC/2 volume formula compared to computer-assisted volumetric analysis of subdural hematomas
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Sae-Yeon Won, Andrea Zagorcic, Daniel Dubinski, Johanna Quick-Weller, Eva Herrmann, Volker Seifert, Juergen Konczalla, and Sherman, Jonathan H.
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Male ,Medical Ethics ,Ellipsoids ,Volumetric Analysis ,Decision Making ,lcsh:Medicine ,Geometry ,Hemorrhage ,macromolecular substances ,Linear Regression Analysis ,Research and Analysis Methods ,Pathology and Laboratory Medicine ,Vascular Medicine ,Analytical Chemistry ,Epidural Block ,Mathematical and Statistical Techniques ,Signs and Symptoms ,Chemical Analysis ,Drug Therapy ,Diagnostic Medicine ,Anesthesiology ,Medicine and Health Sciences ,Humans ,Anesthesia ,ddc:610 ,Statistical Methods ,lcsh:Science ,Pharmaceutics ,lcsh:R ,610 Medical sciences ,Medicine ,Health Care ,Chemistry ,Hematoma, Subdural ,ddc: 610 ,Physical Sciences ,Regression Analysis ,lcsh:Q ,Female ,Local and Regional Anesthesia ,Health Statistics ,Morbidity ,Tomography, X-Ray Computed ,Mathematics ,Statistics (Mathematics) ,Research Article - Abstract
Objective: Subdural hematoma (SDH) is a common disease with increasing incidence and associated high morbidity. Surgical evacuation depends on the clinical appearance and the volume of SDH, so that it is important to have a simple "bedside" method to measure the volume of SDH. The aim of the[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie
- Published
- 2018
200. Repeated in-field radiosurgery for locally recurrent brain metastases: Feasibility, results and survival in a heavily treated patient cohort
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Balermpas, Panagiotis, Stera, Susanne, Müller-von der Grün, Jens, Loutfi-Krauss, Britta, Forster, Marie-Thérèse, Wagner, Marlies, Keller, Christian, Rödel, Claus, Seifert, Volker, Blanck, Oliver, Wolff, Robert, and Sherman, Jonathan H.
- Subjects
Male ,Lung Neoplasms ,Cancer Treatment ,lcsh:Medicine ,Stereotactic Radiosurgery ,Toxicology ,Pathology and Laboratory Medicine ,Lung and Intrathoracic Tumors ,Nervous System Procedures ,Robotic Surgical Procedures ,Carcinoma, Non-Small-Cell Lung ,Breast Tumors ,Medicine and Health Sciences ,lcsh:Science ,Melanoma ,Neurological Tumors ,Aged, 80 and over ,Brain Neoplasms ,Brain ,Middle Aged ,Magnetic Resonance Imaging ,Treatment Outcome ,Oncology ,Neurology ,Retreatment ,Female ,Research Article ,Adult ,Breast Neoplasms ,Surgical and Invasive Medical Procedures ,Radiosurgery ,Necrosis ,Signs and Symptoms ,Diagnostic Medicine ,parasitic diseases ,Breast Cancer ,Humans ,ddc:610 ,Radiation Injuries ,Aged ,Retrospective Studies ,Toxicity ,Patient Selection ,lcsh:R ,Cancers and Neoplasms ,Biology and Life Sciences ,Survival Analysis ,Non-Small Cell Lung Cancer ,Brain Metastasis ,Lesions ,Feasibility Studies ,lcsh:Q ,Neoplasm Recurrence, Local ,Follow-Up Studies - Abstract
Purpose: Stereotactic radiosurgery (SRS) is an established primary treatment for newly diagnosed brain metastases with high local control rates. However, data about local re-irradiation in case of local failure after SRS (re-SRS) are rare. We evaluated the feasibility, efficacy and patient selection characteristics in treating locally recurrent metastases with a second course of SRS. Methods: We retrospectively evaluated patients with brain metastases treated with re-SRS for local tumor progression between 2011 and 2017. Patient and treatment characteristics as well as rates of tumor control, survival and toxicity were analyzed. Results: Overall, 32 locally recurrent brain metastases in 31 patients were irradiated with re-SRS. Median age at re-SRS was 64.9 years. The primary histology was breast cancer and non-small-cellular lung cancer (NSCLC) in respectively 10 cases (31.3%), in 5 cases malignant melanoma (15.6%). In the first SRS-course 19 metastases (59.4%) and in the re-SRS-course 29 metastases (90.6%) were treated with CyberKnife® and the others with Gamma Knife. Median planning target volume (PTV) for re-SRS was 2.5 cm3 (range, 0.1–37.5 cm3) and median dose prescribed to the PTV was 19 Gy (range, 12–28 Gy) in 1–5 fractions to the median 69% isodose (range, 53–80%). The 1-year overall survival rate was 61.7% and the 1-year local control rate was 79.5%. The overall rate of radiological radio-necrosis was 16.1% and four patients (12.9%) experienced grade ≥ 3 toxicities. Conclusions: A second course of SRS for locally recurrent brain metastases after prior local SRS appears to be feasible with acceptable toxicity and can be considered as salvage treatment option for selected patients with high performance status. Furthermore, this is the first study utilizing robotic radiosurgery for this indication, as an additional option for frameless fractionated treatment.
- Published
- 2018
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