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682 results on '"Shiotani, Akihiro"'

154. Clinical features and treatment outcomes of Japanese head and neck cancer patients with a second primary cancer.

Author

Yamashita, Taku, Araki, Koji, Tomifuji, Masayuki, Tanaka, Yuya, Harada, Eiko, Suzuki, Tatsutoshi, Miyamoto, Shunsuke, and Shiotani, Akihiro

Subjects
HEAD & neck cancer diagnosis, HEAD & neck cancer treatment, JAPANESE people, CANCER risk factors, ALDEHYDE dehydrogenase, IMMUNOHISTOCHEMISTRY, HEALTH
Abstract

Aim It has been well established that patients with head and neck cancer (HNC) have an elevated risk of developing a second primary cancer (SPC), owing to the common carcinogenic risk factors, including tobacco and alcohol consumption, and inactive aldehyde dehydrogenase-2 genotype. Here we investigated the current state of SPC in Japanese HNC patients. Methods We retrospectively investigated the incidence and treatment outcomes of synchronous and metachronous SPCs among 434 newly diagnosed HNC patients. Moreover, the associations between various carcinogenic risk factors and SPC were also assessed. Results Fifty-two (12.0%) and 104 patients (24.0%) had synchronous and metachronous SPCs, respectively. The cases with SPC were associated with high rates of smoking and alcohol histories (81.1% and 74.6%, respectively). Immunohistochemical analysis revealed that 47.5% of all oropharyngeal cancer cases showed positive p16 expression, and there was no significant difference between p16-positive and -negative cases in terms of the proportions of patients with SPC. The 3-year overall survival rates were 78.8%, 75.3% and 75.9% in patients without, with synchronous, and with metachronous SPC, respectively ( P = 0.4048). Conclusion Given the distinct features of the carcinogenic risk factors for HNC in Japan, care should be taken not to underestimate the frequency of SPC, even for human papillomavirus-related oropharyngeal cancer patients. Considering the high incidence of SPC associated with HNC, the appropriate diagnostic strategy to allow for early detection of SPC and a treatment strategy aimed at avoiding unnecessary radiotherapy for the index tumor would contribute to improving the prognosis for HNC. [ABSTRACT FROM AUTHOR]

Published
2017
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155. Vocal function after transoral videolaryngoscopic surgery (TOVS) for hypopharyngeal and supraglottic cancer.

Author

Tanaka, Shingo, Tomifuji, Masayuki, Araki, Koji, Uno, Kosuke, Tanaka, Yuya, Mizokami, Daisuke, Suzuki, Hiroshi, Miyagawa, Yoshihiro, Taniai, Shinichi, and Shiotani, Akihiro

Subjects
VOICE disorders, ACADEMIC medical centers, LARYNGOSCOPY, LARYNGEAL tumors, MULTIVARIATE analysis, PROBABILITY theory, RESEARCH funding, PHYSIOLOGICAL aspects of speech, STATISTICS, SURGICAL complications, HYPOPHARYNX, RETROSPECTIVE studies, DATA analysis software, DESCRIPTIVE statistics, TUMORS, DISEASE risk factors
Abstract

Conclusion: The resection of the medial and lateral pyriform sinus was associated with post-operative voice impairment after TOVS. Scar contracture around the cricoarytenoid joint lead to arytenoid fixation toward lateral position, and this wound healing process caused insufficient glottis closure. Although oncological and functional outcomes of TOVS was satisfactory, surgeons should mention the risk of post-operative voice impairment in pre-operative counseling. Objectives: Transoral surgery is a minimally invasive treatment option for hypopharyngeal and supraglottic cancer. Post-operative vocal function was satisfactory in most cases, but in some cases vocal cord was fixed and occasionally voice impairment persists. Methods: Vocal function of 55 patients who underwent transoral videolaryngoscopic surgery (TOVS) for hypopharyngeal and supraglottic cancers was evaluated by the GRBAS perceptive scale, aerodynamic tests and acoustic analyses, and the Voice Handicap Index questionnaire. The risk factors for voice impairment were identified. Results: Voice impairment (G score ≧2) was found in 16 cases (29.1%). Univariate analysis revealed that the resection of medial and lateral pyriform sinus (p =.0018) and neck dissection (p =.0421) were associated with post-operative voice impairment. Multivariate analysis revealed that the resection of medial and lateral pyriform sinus (p =.0021) was associated with post-operative voice impairment. [ABSTRACT FROM AUTHOR]

Published
2017
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162. “Reverse” Bypass Using a Naturally Formed “Bonnet” Superficial Temporal Artery in Symptomatic Common Carotid Artery Occlusion: A Case Report

Author

OTANI, Naoki, primary, WADA, Kojiro, additional, SAKAKIBARA, Fumihiro, additional, NAGATANI, Kimihiro, additional, TAKEUCHI, Satoru, additional, TOMURA, Satoshi, additional, OSADA, Hideo, additional, MIZOKAMI, Daisuke, additional, YAMASHITA, Takuji, additional, SHIOTANI, Akihiro, additional, and MORI, Kentaro, additional

Published
2014
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178. Value of a novel PGA-collagen tube on recurrent laryngeal nerve regeneration in a rat model.

Author

Suzuki, Hiroshi, Araki, Koji, Matsui, Toshiyasu, Tomifuji, Masayuki, Yamashita, Taku, Kobayashi, Yasushi, and Shiotani, Akihiro

Abstract

Objectives/hypothesis: Nerbridge (Toyobo Co., Ltd., Osaka, Japan) is a novel polyglycolic acid (PGA) tube that is filled with collagen fibers and that facilitates nerve fiber expansion and blood vessel growth. It is biocompatible and commercially available, with governmental approval for practical use in Japan. We hypothesized that the PGA-collagen tube would promote regeneration of the recurrent laryngeal nerve (RLN). This hypothesis was examined in a rat axotomy model of the RLN.Study Design: Prospective animal study.Methods: The axotomy model was established by transection of the left RLN in adult Sprague-Dawley rats. The cut ends of the nerve were bridged using Nerbridge (Toyobo Co., Ltd.) with a 1-mm gap (tube-treatment group) or direct sutures (sutured-control group). Left vocal fold mobility, nerve conduction velocity, morphology, and histology were assessed after 15 weeks.Results: Fifteen weeks after treatment, nerve fiber connections were observed macroscopically in both groups, and more clear myelinated fibers and better prevention of laryngeal muscle atrophy were observed in the tube-treatment group compared with the sutured-control group. However, vocal fold movement recovery was not observed in either group, and the conduction velocity of the RLN did not differ between the two groups.Conclusions: Better nerve regeneration was observed in the tube-treatment group. The combination therapy with molecular or gene therapy might be an effective strategy to improve vocal fold movement. The PGA-collagen tube has the potential to promote regeneration of the RLN and to be a scaffold for drug administration in these combination therapies.Level Of Evidence: N/A. Laryngoscope, 126:E233-E239, 2016. [ABSTRACT FROM AUTHOR]

Published
2016
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188. Lymphoepithelial Cyst of the Hypopharynx

Author

Kawaida, Masahiro, Fukuda, Hiroyuki, Shiotani, Akihiro, and Kohno, Naoyuki

Subjects
Article Subject, parasitic diseases, otorhinolaryngologic diseases
Abstract

A rare case of lymphoepithelial cyst formed in the piriform sinus of the hypopharynx is reported. Histopathological examination revealed a lymphoepithelial cyst. It was removed by laryngomicrosurgical technique using a side-opened direct laryngoscope. Because this cyst was wide-based on the antero-medial region in the right piriform sinus of the hypopharynx, the mucous membrane around the cyst was incised electrosurgically and then detached to facilitate removal. In this paper, we describe our surgical procedure for removing the cyst in this case and discuss the possible causes of the disease.

Published
1995
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198. Relationship between globus sensation and esophageal clearance

Author

Adachi, Jin, primary, Ohmae, Yukio, additional, Karaho, Takehiro, additional, Tanabe, Tetsuya, additional, Mizokami, Daisuke, additional, Hirota, Kouji, additional, Tomifuji, Masayuki, additional, Kurita, Akihiro, additional, Matsunobu, Takeshi, additional, and Shiotani, Akihiro, additional

Published
2010
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