Search

Introduction: There is few data available regarding differences in body composition and its possible changes in patients with ankylosing spondylitis (AS) treated with biological disease-modifying anti-rheumatic drugs (bDMARDs). Objectives: To evaluate changes in body composition in patients with[for full text, please go to the a.m. URL], Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)

Einleitung: Die axiale Spondyloarthritis (axSpA) ist eine schwere chronisch entzündliche Erkrankung mit Auswirkungen auf die Lebensqualität und den Funktionsstatus. Etwa 20-30% der axSpA-Patienten zeigen Symptome einer Depression oder haben eine diagnostizierte Depression [ref:1].[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)

Introduction: Data on the impact of different components of the body composition (BC) on the response to biological disease-modifying anti-rheumatic drugs (bDMARDs) are lacking. Objectives: To investigate the impact of BC on the response to biological disease-modifying anti-rheumatic drugs (bDMARD)[for full text, please go to the a.m. URL], Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)

ObjectivesThe Assessment of SpondyloArthritis international Society (ASAS) MRI working group conducted a multireader exercise on MRI scans from the ASAS classification cohort to assess the spectrum and evolution of lesions in the sacroiliac joint and impact of discrepancies with local readers on numbers of patients classified as axial spondyloarthritis (axSpA).MethodsSeven readers assessed baseline scans from 278 cases and 8 readers assessed baseline and follow-up scans from 107 cases. Agreement for detection of MRI lesions between central and local readers was assessed descriptively and by the kappa statistic. We calculated the number of patients classified as axSpA by the ASAS criteria after replacing local detection of active lesions by central readers and replacing local reader radiographic sacroiliitis by central reader structural lesions on MRI.ResultsStructural lesions, especially erosions, were as frequent as active lesions (≈40%), the majority of patients having both types of lesions. The ASAS definitions for active MRI lesion typical of axSpA and erosion were comparatively discriminatory between axSpA and non-axSpA. Local reader overcall for active MRI lesions was about 30% but this had a minor impact on the number of patients (6.4%) classified as axSpA. Substitution of radiography with MRI structural lesions also had little impact on classification status (1.4%).ConclusionDespite substantial discrepancy between central and local readers in interpretation of both types of MRI lesion, this had a minor impact on the numbers of patients classified as axSpA supporting the robustness of the ASAS criteria for differences in assessment of imaging.

Objectives: To develop and validate an artificial neural network for the detection of definite radiographic sacroiliitis as a manifestation of axial spondyloarthritis. Methods: Conventional radiographs of sacroiliac joints from two independent cohorts of patients with axial spondyloarthritis (axSpA) were used. The first cohort consisted of 1669 radiographs and was used for training and validation of a neural network. The second cohort consisted of 525 radiographs, of which 100 radiographs were randomly selected for the test dataset. In both cohorts all radiographs underwent central reading; the final decision on the presence or absence of definite radiographic sacroiliitis was used as a reference. For performance evaluation of the neural network, areas under the receiver operating characteristic curves (AUROC) were calculated. Sensitivity and specificity for the prediction cut-offs were calculated. Cohens Kappa and the absolute agreement were used to assess the agreement between the neural network and the human readers. Results: The neural network achieved an excellent performance in recognition of definite radiographic sacroiliitis with AUROC of 0.97 and 0.96 for the validation and test datasets, respectively. Sensitivity and specificity for the cut-off weighting both measurements equally were 0.90 and 0.93 for the validation and 0.87 and 0.97 for the test set. The Cohens kappa between the neural network and the reference judgements were 0.80 for both validation and test sets, and the absolute agreement on the classification yielded 91% and 90%, respectively. Conclusions: Artificial neural networks enable the accurate detection of definite radiographic sacroiliitis relevant for the diagnosis and classification of axSpA.

Supplemental material, sj-pdf-3-tab-10.1177_1759720X20972610 for The impact of extra-musculoskeletal manifestations on disease activity, functional status, and treatment patterns in patients with axial spondyloarthritis: results from a nationwide population-based study by Imke Redeker, Britta Siegmund, Kamran Ghoreschi, Uwe Pleyer, Johanna Callhoff, Falk Hoffmann, Ursula Marschall, Hildrun Haibel, Joachim Sieper, Angela Zink and Denis Poddubnyy in Therapeutic Advances in Musculoskeletal Disease

Additional file 1: A univariable association of comorbidities with disease activity and functional impairment in patients with axial spondyloarthritis (N=1,776). Results from univariable linear regression models analysing the association of comorbidities with a prevalence >5% with disease activity and functional impairment.

Supplemental material, sj-pdf-1-tab-10.1177_1759720X20972610 for The impact of extra-musculoskeletal manifestations on disease activity, functional status, and treatment patterns in patients with axial spondyloarthritis: results from a nationwide population-based study by Imke Redeker, Britta Siegmund, Kamran Ghoreschi, Uwe Pleyer, Johanna Callhoff, Falk Hoffmann, Ursula Marschall, Hildrun Haibel, Joachim Sieper, Angela Zink and Denis Poddubnyy in Therapeutic Advances in Musculoskeletal Disease

Supplemental material, sj-pdf-2-tab-10.1177_1759720X20972610 for The impact of extra-musculoskeletal manifestations on disease activity, functional status, and treatment patterns in patients with axial spondyloarthritis: results from a nationwide population-based study by Imke Redeker, Britta Siegmund, Kamran Ghoreschi, Uwe Pleyer, Johanna Callhoff, Falk Hoffmann, Ursula Marschall, Hildrun Haibel, Joachim Sieper, Angela Zink and Denis Poddubnyy in Therapeutic Advances in Musculoskeletal Disease

Supplemental material, sj-pdf-4-tab-10.1177_1759720X20972610 for The impact of extra-musculoskeletal manifestations on disease activity, functional status, and treatment patterns in patients with axial spondyloarthritis: results from a nationwide population-based study by Imke Redeker, Britta Siegmund, Kamran Ghoreschi, Uwe Pleyer, Johanna Callhoff, Falk Hoffmann, Ursula Marschall, Hildrun Haibel, Joachim Sieper, Angela Zink and Denis Poddubnyy in Therapeutic Advances in Musculoskeletal Disease

Background: It is presumed that the phenotype of the axial spondyloarthritis (axSpA) may differ in females and males, but the published data are controversial. The objective of the study was to explore the sex differences in disease features and radiographic progression in axSpA. Methods: A total[for full text, please go to the a.m. URL], 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Einleitung: Die Datengrundlage zur Prävalenz von Komorbiditäten und deren Assoziation mit der Krankheitsaktivität und der Funktionseinschränkung bei Patienten mit axialer Spondyloarthritis (axSpA) ist gering. Ziel dieser Studie war es, die Prävalenz von Komorbiditäten zu[zum vollständigen Text gelangen Sie über die oben angegebene URL], 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Background: Psoriasis occurs in approximately 10% of patients with axial spondyloarthritis (axSpA). It has been noted that such an association may result in a particular phenotype of the disease, which has not been extensively investigated so far. We analyzed the association between clinical manifestations[for full text, please go to the a.m. URL], 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)